NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|62511163|sp|Q7L8A9|]
View 

RecName: Full=Tubulinyl-Tyr carboxypeptidase 1; AltName: Full=Tubulin carboxypeptidase 1; AltName: Full=Tyrosine carboxypeptidase 1; Short=TTCP 1; AltName: Full=Vasohibin-1

Protein Classification

Vasohibin domain-containing protein( domain architecture ID 10632466)

Vasohibin domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Vasohibin pfam14822
Vasohibin; This family of proteins function as angiogenesis inhibitors in animals. Reversible ...
58-302 0e+00

Vasohibin; This family of proteins function as angiogenesis inhibitors in animals. Reversible detyrosination of alpha-tubulin is crucial to microtubule dynamics and functions and defects have been implicated in cancer, brain disorganization, and cardiomyopathies. VASH1 and its homolog VASH2, when complexed with SVBP, exhibited robust and specific Tyr/Phe carboxypeptidase activity on microtubules.


:

Pssm-ID: 434242  Cd Length: 245  Bit Score: 502.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62511163    58 VPFFVNRGGLPVDEATWERMWKHVAKIHPDGEKVAQRIRGATDLPKIPIPSVPTFQPSTPVPERLEAVQRYIRELQYNHT 137
Cdd:pfam14822   1 VPFYVNRGGFPIDDETWERMWSHVAKVHPDGEEMVDRIRNATDLPKVPVPSVPTFQPSMTVPDRLEAIQNYIRELQYNHT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62511163   138 GTQFFEIKKSRPLTGLMDLAKEMTKEALPIKCLEAVILGIYLTNSMPTLERFPISFKTYFSGNYFRHIVLGVNFAGRYGA 217
Cdd:pfam14822  81 GTQFFEIKKSRPLSGLMETAKEMIRESLPIKCLEAVILGIYLTNGYPNLERFPISFKSQFSGHHFRHIVLGVHHNGRYGA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62511163   218 LGMSRREDLMYKPPAFRTLSELVLDFEAAYGRCWHVLKKVKLGQSVSHDPHSVEQIEWKHSVLDVERLGRDDFRKELERH 297
Cdd:pfam14822 161 LGLSRRQDLMYKPLTFRTLSDLIFDFEDSYEKYWHTLKKVKIGLYVPHDPHSCQPIEWKHLVLNVSKLGREDLRKELEKH 240

                  ....*
gi 62511163   298 ARDMR 302
Cdd:pfam14822 241 SRDMR 245
 
Name Accession Description Interval E-value
Vasohibin pfam14822
Vasohibin; This family of proteins function as angiogenesis inhibitors in animals. Reversible ...
58-302 0e+00

Vasohibin; This family of proteins function as angiogenesis inhibitors in animals. Reversible detyrosination of alpha-tubulin is crucial to microtubule dynamics and functions and defects have been implicated in cancer, brain disorganization, and cardiomyopathies. VASH1 and its homolog VASH2, when complexed with SVBP, exhibited robust and specific Tyr/Phe carboxypeptidase activity on microtubules.


Pssm-ID: 434242  Cd Length: 245  Bit Score: 502.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62511163    58 VPFFVNRGGLPVDEATWERMWKHVAKIHPDGEKVAQRIRGATDLPKIPIPSVPTFQPSTPVPERLEAVQRYIRELQYNHT 137
Cdd:pfam14822   1 VPFYVNRGGFPIDDETWERMWSHVAKVHPDGEEMVDRIRNATDLPKVPVPSVPTFQPSMTVPDRLEAIQNYIRELQYNHT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62511163   138 GTQFFEIKKSRPLTGLMDLAKEMTKEALPIKCLEAVILGIYLTNSMPTLERFPISFKTYFSGNYFRHIVLGVNFAGRYGA 217
Cdd:pfam14822  81 GTQFFEIKKSRPLSGLMETAKEMIRESLPIKCLEAVILGIYLTNGYPNLERFPISFKSQFSGHHFRHIVLGVHHNGRYGA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62511163   218 LGMSRREDLMYKPPAFRTLSELVLDFEAAYGRCWHVLKKVKLGQSVSHDPHSVEQIEWKHSVLDVERLGRDDFRKELERH 297
Cdd:pfam14822 161 LGLSRRQDLMYKPLTFRTLSDLIFDFEDSYEKYWHTLKKVKIGLYVPHDPHSCQPIEWKHLVLNVSKLGREDLRKELEKH 240

                  ....*
gi 62511163   298 ARDMR 302
Cdd:pfam14822 241 SRDMR 245
 
Name Accession Description Interval E-value
Vasohibin pfam14822
Vasohibin; This family of proteins function as angiogenesis inhibitors in animals. Reversible ...
58-302 0e+00

Vasohibin; This family of proteins function as angiogenesis inhibitors in animals. Reversible detyrosination of alpha-tubulin is crucial to microtubule dynamics and functions and defects have been implicated in cancer, brain disorganization, and cardiomyopathies. VASH1 and its homolog VASH2, when complexed with SVBP, exhibited robust and specific Tyr/Phe carboxypeptidase activity on microtubules.


Pssm-ID: 434242  Cd Length: 245  Bit Score: 502.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62511163    58 VPFFVNRGGLPVDEATWERMWKHVAKIHPDGEKVAQRIRGATDLPKIPIPSVPTFQPSTPVPERLEAVQRYIRELQYNHT 137
Cdd:pfam14822   1 VPFYVNRGGFPIDDETWERMWSHVAKVHPDGEEMVDRIRNATDLPKVPVPSVPTFQPSMTVPDRLEAIQNYIRELQYNHT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62511163   138 GTQFFEIKKSRPLTGLMDLAKEMTKEALPIKCLEAVILGIYLTNSMPTLERFPISFKTYFSGNYFRHIVLGVNFAGRYGA 217
Cdd:pfam14822  81 GTQFFEIKKSRPLSGLMETAKEMIRESLPIKCLEAVILGIYLTNGYPNLERFPISFKSQFSGHHFRHIVLGVHHNGRYGA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62511163   218 LGMSRREDLMYKPPAFRTLSELVLDFEAAYGRCWHVLKKVKLGQSVSHDPHSVEQIEWKHSVLDVERLGRDDFRKELERH 297
Cdd:pfam14822 161 LGLSRRQDLMYKPLTFRTLSDLIFDFEDSYEKYWHTLKKVKIGLYVPHDPHSCQPIEWKHLVLNVSKLGREDLRKELEKH 240

                  ....*
gi 62511163   298 ARDMR 302
Cdd:pfam14822 241 SRDMR 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH