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Conserved domains on  [gi|74693976|sp|Q758W7|]
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RecName: Full=DNA damage checkpoint control protein RAD17

Protein Classification

Rad1/Rec1/Rad17 family repair protein( domain architecture ID 12031406)

Rad1/Rec1/Rad17 family repair protein similar to Homo sapiens cell cycle checkpoint protein RAD1, Saccharomyces cerevisiae DNA damage checkpoint control protein RAD17 and Ustilago maydis DNA repair exonuclease REC1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rad1 pfam02144
Repair protein Rad1/Rec1/Rad17;
8-268 8.53e-99

Repair protein Rad1/Rec1/Rad17;


:

Pssm-ID: 396631  Cd Length: 257  Bit Score: 294.18  E-value: 8.53e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74693976     8 FSATTIHLDRLMCAFNCMTPFgqrDDVLITIDRDGLTFIRQNNHAAEIQLFLAKELFQYYSIREG--------FEGEIQL 79
Cdd:pfam02144   1 FSATTSNVRHLYTLLKCIGFV---DKALVQISSDGLKFTVEDNRVIQAQAFLDKALFSSYNFNPPtaqdddddEEDSPSF 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74693976    80 CMKLNHLLDTVSVANRDKDDVV--ECTLSYDGEGTPFMLILEDSMITEQVEYATYLVGemDRTGLELDRARLEFECILKG 157
Cdd:pfam02144  78 CLNLSALLDCLNIFGGNDDSSVktSCRMSYKGEGSPLVLILEEDGVTTTCELSTYEPE--DDLDLDLDRDEVVFKVILKS 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74693976   158 DVLYSALRDLREIgCKECYLYIvtSSRARPMFALVSRGQLGLSKIILPSERSVLEKLEVYEndsttlIHDAPVIGLFDFA 237
Cdd:pfam02144 156 DWLHNALRELDET-SEELYISA--SPTDAPHFALSSFGELGSSKVEFPNESSVLETFECYD------LGDEIVISRYKFS 226

                         250       260       270
                  ....*....|....*....|....*....|.
gi 74693976   238 ALDKLRPSTKIASKVLIRKDVHGLLAVNILS 268
Cdd:pfam02144 227 LLKKARKALALASKVSIRMDVRGLLSLQFMI 257
 
Name Accession Description Interval E-value
Rad1 pfam02144
Repair protein Rad1/Rec1/Rad17;
8-268 8.53e-99

Repair protein Rad1/Rec1/Rad17;


Pssm-ID: 396631  Cd Length: 257  Bit Score: 294.18  E-value: 8.53e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74693976     8 FSATTIHLDRLMCAFNCMTPFgqrDDVLITIDRDGLTFIRQNNHAAEIQLFLAKELFQYYSIREG--------FEGEIQL 79
Cdd:pfam02144   1 FSATTSNVRHLYTLLKCIGFV---DKALVQISSDGLKFTVEDNRVIQAQAFLDKALFSSYNFNPPtaqdddddEEDSPSF 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74693976    80 CMKLNHLLDTVSVANRDKDDVV--ECTLSYDGEGTPFMLILEDSMITEQVEYATYLVGemDRTGLELDRARLEFECILKG 157
Cdd:pfam02144  78 CLNLSALLDCLNIFGGNDDSSVktSCRMSYKGEGSPLVLILEEDGVTTTCELSTYEPE--DDLDLDLDRDEVVFKVILKS 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74693976   158 DVLYSALRDLREIgCKECYLYIvtSSRARPMFALVSRGQLGLSKIILPSERSVLEKLEVYEndsttlIHDAPVIGLFDFA 237
Cdd:pfam02144 156 DWLHNALRELDET-SEELYISA--SPTDAPHFALSSFGELGSSKVEFPNESSVLETFECYD------LGDEIVISRYKFS 226

                         250       260       270
                  ....*....|....*....|....*....|.
gi 74693976   238 ALDKLRPSTKIASKVLIRKDVHGLLAVNILS 268
Cdd:pfam02144 227 LLKKARKALALASKVSIRMDVRGLLSLQFMI 257
PCNA cd00577
Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These ...
 32-272 6.52e-30

Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the attachment of the polymerase. The trimeric PCNA ring is structurally similar to the dimeric ring formed by the DNA polymerase processivity factors in bacteria (beta subunit DNA polymerase III holoenzyme) and in bacteriophages (catalytic subunits in T4 and RB69). This structural correspondence further substantiates the mechanistic connection between eukaryotic and prokaryotic DNA replication that has been suggested on biochemical grounds. PCNA is also involved with proteins involved in cell cycle processes such as DNA repair and apoptosis. Many of these proteins contain a highly conserved motif known as the PIP-box (PCNA interacting protein box) which contains the sequence Qxx[LIM]xxF[FY].


Pssm-ID: 238322 [Multi-domain]  Cd Length: 248  Bit Score: 115.42  E-value: 6.52e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74693976  32 DDVLITIDRDGLTFIRQNN-HAAEIQLFLAKELFQYYSIREgfegEIQLCMKLNHLLDTVSVANRDKddvvECTLSYDGE 110
Cdd:cd00577  21 DEANFDITEDGISLQAMDSsHVALVSLFLPKELFEEYRCDE----EISLGVNLKSLLKILKCAGNED----CVTLRADDE 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74693976 111 gTPFMLILEDSMiteQVEYATYLVGEMDRTGLELDRARLEFEC--ILKGDVLYSALRDLREIGckECYLYIVTSSRarpm 188
Cdd:cd00577  93 -DPLKILFESSK---GDVTSEFSLKLMDIDSEQLPIPELEYDAtvTLPSDELKDIVRDLESIS--DSVTISASKDG---- 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74693976 189 FALVSRGQLGLSKIILPSERSVLEklevyendsTTLIHDAPVIGLFDFAALDKLRPSTKIASKVLIRKDVHGLLAVNILS 268
Cdd:cd00577 163 FKFSAEGELGGASVTLLPKDSDLL---------VTIECSEPVSSTYSLKYLKDFTKAAPLSDKVTLSFGSDGPLSLEFKI 233


                ....
gi 74693976 269 DTNA 272
Cdd:cd00577 234 ADGG 237
 
Name Accession Description Interval E-value
Rad1 pfam02144
Repair protein Rad1/Rec1/Rad17;
8-268 8.53e-99

Repair protein Rad1/Rec1/Rad17;


Pssm-ID: 396631  Cd Length: 257  Bit Score: 294.18  E-value: 8.53e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74693976     8 FSATTIHLDRLMCAFNCMTPFgqrDDVLITIDRDGLTFIRQNNHAAEIQLFLAKELFQYYSIREG--------FEGEIQL 79
Cdd:pfam02144   1 FSATTSNVRHLYTLLKCIGFV---DKALVQISSDGLKFTVEDNRVIQAQAFLDKALFSSYNFNPPtaqdddddEEDSPSF 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74693976    80 CMKLNHLLDTVSVANRDKDDVV--ECTLSYDGEGTPFMLILEDSMITEQVEYATYLVGemDRTGLELDRARLEFECILKG 157
Cdd:pfam02144  78 CLNLSALLDCLNIFGGNDDSSVktSCRMSYKGEGSPLVLILEEDGVTTTCELSTYEPE--DDLDLDLDRDEVVFKVILKS 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74693976   158 DVLYSALRDLREIgCKECYLYIvtSSRARPMFALVSRGQLGLSKIILPSERSVLEKLEVYEndsttlIHDAPVIGLFDFA 237
Cdd:pfam02144 156 DWLHNALRELDET-SEELYISA--SPTDAPHFALSSFGELGSSKVEFPNESSVLETFECYD------LGDEIVISRYKFS 226

                         250       260       270
                  ....*....|....*....|....*....|.
gi 74693976   238 ALDKLRPSTKIASKVLIRKDVHGLLAVNILS 268
Cdd:pfam02144 227 LLKKARKALALASKVSIRMDVRGLLSLQFMI 257
PCNA cd00577
Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These ...
 32-272 6.52e-30

Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the attachment of the polymerase. The trimeric PCNA ring is structurally similar to the dimeric ring formed by the DNA polymerase processivity factors in bacteria (beta subunit DNA polymerase III holoenzyme) and in bacteriophages (catalytic subunits in T4 and RB69). This structural correspondence further substantiates the mechanistic connection between eukaryotic and prokaryotic DNA replication that has been suggested on biochemical grounds. PCNA is also involved with proteins involved in cell cycle processes such as DNA repair and apoptosis. Many of these proteins contain a highly conserved motif known as the PIP-box (PCNA interacting protein box) which contains the sequence Qxx[LIM]xxF[FY].


Pssm-ID: 238322 [Multi-domain]  Cd Length: 248  Bit Score: 115.42  E-value: 6.52e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74693976  32 DDVLITIDRDGLTFIRQNN-HAAEIQLFLAKELFQYYSIREgfegEIQLCMKLNHLLDTVSVANRDKddvvECTLSYDGE 110
Cdd:cd00577  21 DEANFDITEDGISLQAMDSsHVALVSLFLPKELFEEYRCDE----EISLGVNLKSLLKILKCAGNED----CVTLRADDE 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74693976 111 gTPFMLILEDSMiteQVEYATYLVGEMDRTGLELDRARLEFEC--ILKGDVLYSALRDLREIGckECYLYIVTSSRarpm 188
Cdd:cd00577  93 -DPLKILFESSK---GDVTSEFSLKLMDIDSEQLPIPELEYDAtvTLPSDELKDIVRDLESIS--DSVTISASKDG---- 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74693976 189 FALVSRGQLGLSKIILPSERSVLEklevyendsTTLIHDAPVIGLFDFAALDKLRPSTKIASKVLIRKDVHGLLAVNILS 268
Cdd:cd00577 163 FKFSAEGELGGASVTLLPKDSDLL---------VTIECSEPVSSTYSLKYLKDFTKAAPLSDKVTLSFGSDGPLSLEFKI 233


                ....
gi 74693976 269 DTNA 272
Cdd:cd00577 234 ADGG 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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