Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 74796184 1179 CFENEFACDNKRCIPELWVCDKANDCGDNSDEKNC 1213
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 74796184    1052 ECTSNEFKCNNGKCIPNTFVCDNDNDCEDGEDE 1084
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 74796184    417 GKMYWSDWGTFPHIAVAGMDGKNVRIFVNVKLEWPKSVTIDY 458
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 74796184      81 TCAKDQFKCKNQECIPAAKYCDMVNDCLDESDE 113
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 74796184    1501 IIASDLGFVRGMTIDHVKSKLYWSDDFYKTVESSNFDGSQR 1541
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 74796184    890 CQKNNGNCSHVCLPSlITSFICACPPGMELSNDNRTC 926
Cdd:pfam14670    1 CSVNNGGCSHLCLNT-PGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 74796184     355 EVIVTTGLALITGIDVDWITKNIYFADEDNHCIGVCTNDGTYC 397
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20
                 ....*....|....*....|....*....
gi 74796184  172 YQYMCANHRCISLKVVCDKKDDCGDGSDE 200
Cdd:cd00112    4 NEFRCANGRCIPSSWVCDGEDDCGDGSDE 32

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 74796184 1141 CSLNEYRClGTDICLPKNVRCDGKNDCPQSDDEQNC 1176
Cdd:cd00112    1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEENC 35

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|.
gi 74796184    252 GICDQDCMNVPGSYACTCQREYYLENDKRTC 282
Cdd:pfam14670    6 GGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|....
gi 74796184     931 ECSKNEYKCSeHNICIQRNQLCDGIENCPNGEDE 964
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 74796184 1179 CFENEFACDNKRCIPELWVCDKANDCGDNSDEKNC 1213
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 74796184    1052 ECTSNEFKCNNGKCIPNTFVCDNDNDCEDGEDE 1084
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|..
gi 74796184    1179 CFENEFACDNKRCIPELWVCDKANDCGDNSDE 1210
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 74796184   1053 CTSNEFKCNNGKCIPNTFVCDNDNDCEDGEDEA 1085
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 74796184   1179 CFENEFACDNKRCIPELWVCDKANDCGDNSDEKNC 1213
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 74796184      81 TCAKDQFKCKNQECIPAAKYCDMVNDCLDESDE 113
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|...
gi 74796184   36 CEDGYFQCNSGECIPVDKKCDYIDHCIDGSDED 68
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 74796184  974 CKENQFMCKNGDCIRLKDRCNSRYDCTDQSDEQNC 1008
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 74796184      35 KCEDGYFQCNSGECIPVDKKCDYIDHCIDGSDE 67
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|.
gi 74796184 1227 DEFKCSVGTCLPYSKVCDGNRDCPDGSDETG 1257
Cdd:cd00112    4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 74796184     355 EVIVTTGLALITGIDVDWITKNIYFADEDNHCIGVCTNDGTYC 397
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 74796184 1013 CKSDEFQCKfTETCIPKTKMCDSNPDCDDLSDEEDC 1048
Cdd:cd00112    1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....
gi 74796184   1097 MPKMFKCPNGDCISDSLLCNGINDCNDGSDEVHC 1130
Cdd:pfam00057    4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 74796184    125 NKFLCTDGHCINKEWVCDGRNDCPDGNDEWNC 156
Cdd:pfam00057    6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A;

                           10        20
                   ....*....|....*....|....*....
gi 74796184   1227 DEFKCSVGTCLPYSKVCDGNRDCPDGSDE 1255
Cdd:pfam00057    6 NEFQCGSGECIPRSWVCDGDPDCGDGSDE 34

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 74796184     398 TVLIKDTDKPTGVALLPTQGKMYWSDWGTfPHIAVAGMDGKNV 440
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....
gi 74796184     34 TKCEDGYFQCNSGECIPVDKKCDYIDHCIDGSDE 67
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|....
gi 74796184    1012 KCKSDEFQCKfTETCIPKTKMCDSNPDCDDLSDE 1045
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 74796184 1141 CSLNEYRClGTDICLPKNVRCDGKNDCPQSDDEQNC 1176
Cdd:cd00112    1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEENC 35

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|.
gi 74796184    252 GICDQDCMNVPGSYACTCQREYYLENDKRTC 282
Cdd:pfam14670    6 GGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 74796184     81 TCAKDQFKCKNQECIPAAKYCDMVNDCLDESDE 113
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|....
gi 74796184     931 ECSKNEYKCSeHNICIQRNQLCDGIENCPNGEDE 964
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|...
gi 74796184  932 CSKNEYKCSEHNiCIQRNQLCDGIENCPNGEDE 964
Cdd:cd00112    1 CPPNEFRCANGR-CIPSSWVCDGEDDCGDGSDE 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 74796184  244 DIDECQAYGIC--DQDCMNVPGSYACTCQREYYLEN 277
Cdd:cd00054    1 DIDECASGNPCqnGGTCVNTVGSYRCSCPPGYTGRN 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 74796184    1406 EIVTVKIVEHPQALAVDWITGNVYVNDnSHLNTIKVCNLE 1445
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTD-WGLDVIEVANLD 39

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 74796184 1179 CFENEFACDNKRCIPELWVCDKANDCGDNSDEKNC 1213
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 74796184    1052 ECTSNEFKCNNGKCIPNTFVCDNDNDCEDGEDE 1084
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|..
gi 74796184    1179 CFENEFACDNKRCIPELWVCDKANDCGDNSDE 1210
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 74796184   1053 CTSNEFKCNNGKCIPNTFVCDNDNDCEDGEDEA 1085
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 74796184   1179 CFENEFACDNKRCIPELWVCDKANDCGDNSDEKNC 1213
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 74796184      81 TCAKDQFKCKNQECIPAAKYCDMVNDCLDESDE 113
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|...
gi 74796184   36 CEDGYFQCNSGECIPVDKKCDYIDHCIDGSDED 68
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 74796184  974 CKENQFMCKNGDCIRLKDRCNSRYDCTDQSDEQNC 1008
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 74796184      35 KCEDGYFQCNSGECIPVDKKCDYIDHCIDGSDE 67
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|.
gi 74796184 1227 DEFKCSVGTCLPYSKVCDGNRDCPDGSDETG 1257
Cdd:cd00112    4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 74796184     355 EVIVTTGLALITGIDVDWITKNIYFADEDNHCIGVCTNDGTYC 397
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 74796184 1013 CKSDEFQCKfTETCIPKTKMCDSNPDCDDLSDEEDC 1048
Cdd:cd00112    1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....
gi 74796184   1097 MPKMFKCPNGDCISDSLLCNGINDCNDGSDEVHC 1130
Cdd:pfam00057    4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 74796184    125 NKFLCTDGHCINKEWVCDGRNDCPDGNDEWNC 156
Cdd:pfam00057    6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A;

                           10        20
                   ....*....|....*....|....*....
gi 74796184   1227 DEFKCSVGTCLPYSKVCDGNRDCPDGSDE 1255
Cdd:pfam00057    6 NEFQCGSGECIPRSWVCDGDPDCGDGSDE 34

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 74796184     398 TVLIKDTDKPTGVALLPTQGKMYWSDWGTfPHIAVAGMDGKNV 440
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43