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Conserved domains on  [gi|82187405|sp|Q6TEQ0|]
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RecName: Full=Endonuclease/exonuclease/phosphatase family domain-containing protein 1

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MnuA_DNase1-like cd10283
Mycoplasma pulmonis MnuA nuclease-like; This subfamily includes Mycoplasma pulmonis MnuA, a ...
 246-521 2.85e-52

Mycoplasma pulmonis MnuA nuclease-like; This subfamily includes Mycoplasma pulmonis MnuA, a membrane-associated nuclease related to Deoxyribonuclease 1 (DNase1 or DNase I, EC 3.1.21.1). The in vivo role of MnuA is as yet undetermined. This subfamily belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.


:

Pssm-ID: 197338 [Multi-domain]  Cd Length: 266  Bit Score: 179.13  E-value: 2.85e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187405 246 VRVATWNLQRCS--SEKANNPGVKEVVCMTllenDIKLLAVQDLAD----REALDKFCAELNQPtlcsvrrwksaRGLWK 319
Cdd:cd10283   1 LRIASWNILNFGnsKGKEKNPAIAEIISAF----DLDLIALQEVMDngggLDALAKLVNELNKP-----------GGTWK 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187405 320 CAVSEKPNGvSNSAPEFSGFLWDCSSgIEMKDSAVLESFTTNGNGNPhpQPYLGHFYIGSS--ELTLVNVLLTAAPSpte 397
Cdd:cd10283  66 YIVSDKTGG-SSGDKERYAFLYKSSK-VRKVGKAVLEKDSNTDGFAR--PPYAAKFKSGGTgfDFTLVNVHLKSGGS--- 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187405 398 nkrKSTSDDLKTHKLSSGVQETLK------GERDLLVMGHFGVAPDSSEMEILRKEKLSALLAPSvfTNISTRTPQGSRS 471
Cdd:cd10283 139 ---SKSGQGAKRVAEAQALAEYLKeladedPDDDVILLGDFNIPADEDAFKALTKAGFKSLLPDS--TNLSTSFKGYANS 213

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 82187405 472 LDNIWASRSLRKT------YTGQCSVVREGLTnpwIPDNWSWGGVASEHCPVVAEF 521
Cdd:cd10283 214 YDNIFVSGNLKEKfsnsgvFDFNILVDEAGEE---DLDYSKWRKQISDHDPVWVEF 266
HHH_3 pfam12836
Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.
 126-182 8.90e-21

Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.


:

Pssm-ID: 463723 [Multi-domain]  Cd Length: 62  Bit Score: 86.00  E-value: 8.90e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 82187405   126 GVNINTATPPQLMSVRGITEKIAKNIVEFRSVHGPFKSIEDLVKVANINSSLLDRIR 182
Cdd:pfam12836   3 GVDINTASAELLSRVPGLGPKLAKNIVEYREENGPFRSREDLLKVKGLGPKTFEQLA 59
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 39-100 1.01e-20

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


:

Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 86.07  E-value: 1.01e-20
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 82187405  39 ERLNINTATEEELMTLPGVNRGVAQNIVEYRDCIGGFKKVEDLALVSGVGATKLEAIKLEIC 100
Cdd:COG1555  11 GKVDINTATAEELQTLPGIGPKLAQRIVEYREKNGPFKSVEDLLEVKGIGPKTLEKLKPYLT 72
 
Name Accession Description Interval E-value
MnuA_DNase1-like cd10283
Mycoplasma pulmonis MnuA nuclease-like; This subfamily includes Mycoplasma pulmonis MnuA, a ...
 246-521 2.85e-52

Mycoplasma pulmonis MnuA nuclease-like; This subfamily includes Mycoplasma pulmonis MnuA, a membrane-associated nuclease related to Deoxyribonuclease 1 (DNase1 or DNase I, EC 3.1.21.1). The in vivo role of MnuA is as yet undetermined. This subfamily belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.


Pssm-ID: 197338 [Multi-domain]  Cd Length: 266  Bit Score: 179.13  E-value: 2.85e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187405 246 VRVATWNLQRCS--SEKANNPGVKEVVCMTllenDIKLLAVQDLAD----REALDKFCAELNQPtlcsvrrwksaRGLWK 319
Cdd:cd10283   1 LRIASWNILNFGnsKGKEKNPAIAEIISAF----DLDLIALQEVMDngggLDALAKLVNELNKP-----------GGTWK 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187405 320 CAVSEKPNGvSNSAPEFSGFLWDCSSgIEMKDSAVLESFTTNGNGNPhpQPYLGHFYIGSS--ELTLVNVLLTAAPSpte 397
Cdd:cd10283  66 YIVSDKTGG-SSGDKERYAFLYKSSK-VRKVGKAVLEKDSNTDGFAR--PPYAAKFKSGGTgfDFTLVNVHLKSGGS--- 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187405 398 nkrKSTSDDLKTHKLSSGVQETLK------GERDLLVMGHFGVAPDSSEMEILRKEKLSALLAPSvfTNISTRTPQGSRS 471
Cdd:cd10283 139 ---SKSGQGAKRVAEAQALAEYLKeladedPDDDVILLGDFNIPADEDAFKALTKAGFKSLLPDS--TNLSTSFKGYANS 213

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 82187405 472 LDNIWASRSLRKT------YTGQCSVVREGLTnpwIPDNWSWGGVASEHCPVVAEF 521
Cdd:cd10283 214 YDNIFVSGNLKEKfsnsgvFDFNILVDEAGEE---DLDYSKWRKQISDHDPVWVEF 266
HHH_3 pfam12836
Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.
 126-182 8.90e-21

Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.


Pssm-ID: 463723 [Multi-domain]  Cd Length: 62  Bit Score: 86.00  E-value: 8.90e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 82187405   126 GVNINTATPPQLMSVRGITEKIAKNIVEFRSVHGPFKSIEDLVKVANINSSLLDRIR 182
Cdd:pfam12836   3 GVDINTASAELLSRVPGLGPKLAKNIVEYREENGPFRSREDLLKVKGLGPKTFEQLA 59
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 39-100 1.01e-20

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 86.07  E-value: 1.01e-20
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 82187405  39 ERLNINTATEEELMTLPGVNRGVAQNIVEYRDCIGGFKKVEDLALVSGVGATKLEAIKLEIC 100
Cdd:COG1555  11 GKVDINTATAEELQTLPGIGPKLAQRIVEYREKNGPFKSVEDLLEVKGIGPKTLEKLKPYLT 72
HHH_3 pfam12836
Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.
 38-96 1.07e-19

Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.


Pssm-ID: 463723 [Multi-domain]  Cd Length: 62  Bit Score: 82.91  E-value: 1.07e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 82187405    38 QERLNINTATEEELMTLPGVNRGVAQNIVEYRDCIGGFKKVEDLALVSGVGATKLEAIK 96
Cdd:pfam12836   1 AVGVDINTASAELLSRVPGLGPKLAKNIVEYREENGPFRSREDLLKVKGLGPKTFEQLA 59
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 127-182 1.64e-19

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 82.60  E-value: 1.64e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 82187405 127 VNINTATPPQLMSVRGITEKIAKNIVEFRSVHGPFKSIEDLVKVANINSSLLDRIR 182
Cdd:COG1555  13 VDINTATAEELQTLPGIGPKLAQRIVEYREKNGPFKSVEDLLEVKGIGPKTLEKLK 68
comE TIGR01259
comEA protein; This model describes the ComEA protein in bacteria. The com E locus is ...
 41-101 1.91e-12

comEA protein; This model describes the ComEA protein in bacteria. The com E locus is obligatory for bacterial cell competence - the process of internalizing the exogenous added DNA. Lesions in the loci has been variously described for the appearance of competence-related pheonotypes and impairment of competence, suggesting their intimate functional role in bacterial transformation. [Cellular processes, DNA transformation]


Pssm-ID: 213597 [Multi-domain]  Cd Length: 120  Bit Score: 64.15  E-value: 1.91e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 82187405    41 LNINTATEEELMTLPGVNRGVAQNIVEYRDCIGGFKKVEDLALVSGVGATKLEAIKLEICV 101
Cdd:TIGR01259  60 VNINAASLEELQALPGIGPAKAKAIIEYREENGAFKSVDDLTKVSGIGEKSLEKLKDYATV 120
comE TIGR01259
comEA protein; This model describes the ComEA protein in bacteria. The com E locus is ...
 127-187 1.62e-10

comEA protein; This model describes the ComEA protein in bacteria. The com E locus is obligatory for bacterial cell competence - the process of internalizing the exogenous added DNA. Lesions in the loci has been variously described for the appearance of competence-related pheonotypes and impairment of competence, suggesting their intimate functional role in bacterial transformation. [Cellular processes, DNA transformation]


Pssm-ID: 213597 [Multi-domain]  Cd Length: 120  Bit Score: 58.76  E-value: 1.62e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 82187405   127 VNINTATPPQLMSVRGITEKIAKNIVEFRSVHGPFKSIEDLVKVANINSSLLDRIRFQVFV 187
Cdd:TIGR01259  60 VNINAASLEELQALPGIGPAKAKAIIEYREENGAFKSVDDLTKVSGIGEKSLEKLKDYATV 120
PulK COG3156
Type II secretory pathway, component PulK [Intracellular trafficking, secretion, and vesicular ...
 40-185 1.31e-04

Type II secretory pathway, component PulK [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442390 [Multi-domain]  Cd Length: 307  Bit Score: 44.22  E-value: 1.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187405  40 RLNINTATEEE-------------LMTLPGVNRGVAQN----IVEYRD-----CIGG-------------------FKKV 78
Cdd:COG3156 104 CFNLNALVDPDgevnpyaqqvfrrLLEALGLDEYEAEAladaIVDWIDsddlpRPGGaeddyylalgppyrpangpFASV 183

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187405  79 EDLALVSGVGATKLEAIKLEICVssknsssnhspsslrkehehLP-CTGVNINTATPPQLMSV-RGITEKIAKNIVEFRS 156
Cdd:COG3156 184 SELRLVKGMTPELYARLAPYVTA--------------------LPgDTKINVNTAPPEVLAALlGGLSLDDAQALLAARP 243

                       170       180
                ....*....|....*....|....*....
gi 82187405 157 VhGPFKSIEDLVKVANINSSLLDRIRFQV 185
Cdd:COG3156 244 E-KGFADVADFLALLGLAGLDLLKDQLTV 271
T2SS_GspK NF037980
type II secretion system minor pseudopilin GspK;
78-191 3.48e-04

type II secretion system minor pseudopilin GspK;


Pssm-ID: 468299 [Multi-domain]  Cd Length: 311  Bit Score: 42.66  E-value: 3.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187405   78 VEDLALVSGVGATKLEAIKLEICVssknsssnhspsslrkehehLPCTG--VNINTATPPQLMSVR-GITEKIAKNIVEF 154
Cdd:NF037980 182 VSELRLVPGVTPALYARLRPYVCA--------------------LPTTTlaINVNTAPAEVLAALAaLLSLSQARALLAA 241

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 82187405  155 RSvHGPFKSIEDL--------VKVANINSSLLD------RIRFQVFVERSR 191
Cdd:NF037980 242 RP-AAGFRSVGDFlaqlalagLALDASDKEQLGvrsryfLLRGEVRLGEAR 291
polC PRK00448
DNA polymerase III PolC; Validated
 130-179 5.79e-04

DNA polymerase III PolC; Validated


Pssm-ID: 234767 [Multi-domain]  Cd Length: 1437  Bit Score: 42.90  E-value: 5.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 82187405   130 NTATPPqLMSVRGITEKIAKNIVEFRSvHGPFKSIEDLVKVANINSSLLD 179
Cdd:PRK00448 1369 DSLIPP-FNALPGLGENVAKSIVEARE-EGEFLSKEDLRKRTKVSKTLIE 1416
T2SS_GspK NF037980
type II secretion system minor pseudopilin GspK;
34-96 3.49e-03

type II secretion system minor pseudopilin GspK;


Pssm-ID: 468299 [Multi-domain]  Cd Length: 311  Bit Score: 39.58  E-value: 3.49e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 82187405   34 ILVNQERLNINTATEEELMTL-PGVNRGVAQNIVEYRDcIGGFKKVEDLALVSGVGATKLEAIK 96
Cdd:NF037980 206 LPTTTLAINVNTAPAEVLAALaALLSLSQARALLAARP-AAGFRSVGDFLAQLALAGLALDASD 268
 
Name Accession Description Interval E-value
MnuA_DNase1-like cd10283
Mycoplasma pulmonis MnuA nuclease-like; This subfamily includes Mycoplasma pulmonis MnuA, a ...
 246-521 2.85e-52

Mycoplasma pulmonis MnuA nuclease-like; This subfamily includes Mycoplasma pulmonis MnuA, a membrane-associated nuclease related to Deoxyribonuclease 1 (DNase1 or DNase I, EC 3.1.21.1). The in vivo role of MnuA is as yet undetermined. This subfamily belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.


Pssm-ID: 197338 [Multi-domain]  Cd Length: 266  Bit Score: 179.13  E-value: 2.85e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187405 246 VRVATWNLQRCS--SEKANNPGVKEVVCMTllenDIKLLAVQDLAD----REALDKFCAELNQPtlcsvrrwksaRGLWK 319
Cdd:cd10283   1 LRIASWNILNFGnsKGKEKNPAIAEIISAF----DLDLIALQEVMDngggLDALAKLVNELNKP-----------GGTWK 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187405 320 CAVSEKPNGvSNSAPEFSGFLWDCSSgIEMKDSAVLESFTTNGNGNPhpQPYLGHFYIGSS--ELTLVNVLLTAAPSpte 397
Cdd:cd10283  66 YIVSDKTGG-SSGDKERYAFLYKSSK-VRKVGKAVLEKDSNTDGFAR--PPYAAKFKSGGTgfDFTLVNVHLKSGGS--- 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187405 398 nkrKSTSDDLKTHKLSSGVQETLK------GERDLLVMGHFGVAPDSSEMEILRKEKLSALLAPSvfTNISTRTPQGSRS 471
Cdd:cd10283 139 ---SKSGQGAKRVAEAQALAEYLKeladedPDDDVILLGDFNIPADEDAFKALTKAGFKSLLPDS--TNLSTSFKGYANS 213

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 82187405 472 LDNIWASRSLRKT------YTGQCSVVREGLTnpwIPDNWSWGGVASEHCPVVAEF 521
Cdd:cd10283 214 YDNIFVSGNLKEKfsnsgvFDFNILVDEAGEE---DLDYSKWRKQISDHDPVWVEF 266
HHH_3 pfam12836
Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.
 126-182 8.90e-21

Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.


Pssm-ID: 463723 [Multi-domain]  Cd Length: 62  Bit Score: 86.00  E-value: 8.90e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 82187405   126 GVNINTATPPQLMSVRGITEKIAKNIVEFRSVHGPFKSIEDLVKVANINSSLLDRIR 182
Cdd:pfam12836   3 GVDINTASAELLSRVPGLGPKLAKNIVEYREENGPFRSREDLLKVKGLGPKTFEQLA 59
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 39-100 1.01e-20

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 86.07  E-value: 1.01e-20
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 82187405  39 ERLNINTATEEELMTLPGVNRGVAQNIVEYRDCIGGFKKVEDLALVSGVGATKLEAIKLEIC 100
Cdd:COG1555  11 GKVDINTATAEELQTLPGIGPKLAQRIVEYREKNGPFKSVEDLLEVKGIGPKTLEKLKPYLT 72
HHH_3 pfam12836
Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.
 38-96 1.07e-19

Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.


Pssm-ID: 463723 [Multi-domain]  Cd Length: 62  Bit Score: 82.91  E-value: 1.07e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 82187405    38 QERLNINTATEEELMTLPGVNRGVAQNIVEYRDCIGGFKKVEDLALVSGVGATKLEAIK 96
Cdd:pfam12836   1 AVGVDINTASAELLSRVPGLGPKLAKNIVEYREENGPFRSREDLLKVKGLGPKTFEQLA 59
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 127-182 1.64e-19

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 82.60  E-value: 1.64e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 82187405 127 VNINTATPPQLMSVRGITEKIAKNIVEFRSVHGPFKSIEDLVKVANINSSLLDRIR 182
Cdd:COG1555  13 VDINTATAEELQTLPGIGPKLAQRIVEYREKNGPFKSVEDLLEVKGIGPKTLEKLK 68
comE TIGR01259
comEA protein; This model describes the ComEA protein in bacteria. The com E locus is ...
 41-101 1.91e-12

comEA protein; This model describes the ComEA protein in bacteria. The com E locus is obligatory for bacterial cell competence - the process of internalizing the exogenous added DNA. Lesions in the loci has been variously described for the appearance of competence-related pheonotypes and impairment of competence, suggesting their intimate functional role in bacterial transformation. [Cellular processes, DNA transformation]


Pssm-ID: 213597 [Multi-domain]  Cd Length: 120  Bit Score: 64.15  E-value: 1.91e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 82187405    41 LNINTATEEELMTLPGVNRGVAQNIVEYRDCIGGFKKVEDLALVSGVGATKLEAIKLEICV 101
Cdd:TIGR01259  60 VNINAASLEELQALPGIGPAKAKAIIEYREENGAFKSVDDLTKVSGIGEKSLEKLKDYATV 120
Tex COG2183
Transcriptional accessory protein Tex/SPT6 [Transcription];
126-171 5.08e-12

Transcriptional accessory protein Tex/SPT6 [Transcription];


Pssm-ID: 441786 [Multi-domain]  Cd Length: 719  Bit Score: 68.51  E-value: 5.08e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 82187405 126 GVNINTATPPQLMSVRGITEKIAKNIVEFRSVHGPFKSIEDLVKVA 171
Cdd:COG2183 486 GVDLNTASAPLLSYVSGLNPTLAKNIVAYRDENGAFKSRKELLKVP 531
comE TIGR01259
comEA protein; This model describes the ComEA protein in bacteria. The com E locus is ...
 127-187 1.62e-10

comEA protein; This model describes the ComEA protein in bacteria. The com E locus is obligatory for bacterial cell competence - the process of internalizing the exogenous added DNA. Lesions in the loci has been variously described for the appearance of competence-related pheonotypes and impairment of competence, suggesting their intimate functional role in bacterial transformation. [Cellular processes, DNA transformation]


Pssm-ID: 213597 [Multi-domain]  Cd Length: 120  Bit Score: 58.76  E-value: 1.62e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 82187405   127 VNINTATPPQLMSVRGITEKIAKNIVEFRSVHGPFKSIEDLVKVANINSSLLDRIRFQVFV 187
Cdd:TIGR01259  60 VNINAASLEELQALPGIGPAKAKAIIEYREENGAFKSVDDLTKVSGIGEKSLEKLKDYATV 120
TIGR00426 TIGR00426
competence protein ComEA helix-hairpin-helix repeat region; Members of the subfamily ...
 125-182 5.56e-10

competence protein ComEA helix-hairpin-helix repeat region; Members of the subfamily recognized by this model include competence protein ComEA and closely related proteins from a number of species that exhibit competence for transformation by exongenous DNA, including Streptococcus pneumoniae, Bacillus subtilis, Neisseria meningitidis, and Haemophilus influenzae. This model represents a region of two tandem copies of a helix-hairpin-helix domain (pfam00633), each about 30 residues in length. Limited sequence similarity can be found among some members of this family N-terminal to the region covered by this model. [Cellular processes, DNA transformation]


Pssm-ID: 129520 [Multi-domain]  Cd Length: 69  Bit Score: 55.71  E-value: 5.56e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 82187405   125 TGVNINTATPPQLM-SVRGITEKIAKNIVEFRSVHGPFKSIEDLVKVANINSSLLDRIR 182
Cdd:TIGR00426   6 TRVNINTATAEELQrAMNGVGLKKAEAIVSYREEYGPFKTVEDLKQVPGIGNSLVEKNL 64
TIGR00426 TIGR00426
competence protein ComEA helix-hairpin-helix repeat region; Members of the subfamily ...
 40-101 7.68e-10

competence protein ComEA helix-hairpin-helix repeat region; Members of the subfamily recognized by this model include competence protein ComEA and closely related proteins from a number of species that exhibit competence for transformation by exongenous DNA, including Streptococcus pneumoniae, Bacillus subtilis, Neisseria meningitidis, and Haemophilus influenzae. This model represents a region of two tandem copies of a helix-hairpin-helix domain (pfam00633), each about 30 residues in length. Limited sequence similarity can be found among some members of this family N-terminal to the region covered by this model. [Cellular processes, DNA transformation]


Pssm-ID: 129520 [Multi-domain]  Cd Length: 69  Bit Score: 54.94  E-value: 7.68e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 82187405    40 RLNINTATEEELM-TLPGVNRGVAQNIVEYRDCIGGFKKVEDLALVSGVGATKLEAIKLEICV 101
Cdd:TIGR00426   7 RVNINTATAEELQrAMNGVGLKKAEAIVSYREEYGPFKTVEDLKQVPGIGNSLVEKNLAVITL 69
Tex COG2183
Transcriptional accessory protein Tex/SPT6 [Transcription];
36-89 1.00e-05

Transcriptional accessory protein Tex/SPT6 [Transcription];


Pssm-ID: 441786 [Multi-domain]  Cd Length: 719  Bit Score: 48.48  E-value: 1.00e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 82187405  36 VNQERLNINTATEEELMTLPGVNRGVAQNIVEYRDCIGGFKKVEDLALVSGVGA 89
Cdd:COG2183 482 VNAVGVDLNTASAPLLSYVSGLNPTLAKNIVAYRDENGAFKSRKELLKVPRLGP 535
PulK COG3156
Type II secretory pathway, component PulK [Intracellular trafficking, secretion, and vesicular ...
 40-185 1.31e-04

Type II secretory pathway, component PulK [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442390 [Multi-domain]  Cd Length: 307  Bit Score: 44.22  E-value: 1.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187405  40 RLNINTATEEE-------------LMTLPGVNRGVAQN----IVEYRD-----CIGG-------------------FKKV 78
Cdd:COG3156 104 CFNLNALVDPDgevnpyaqqvfrrLLEALGLDEYEAEAladaIVDWIDsddlpRPGGaeddyylalgppyrpangpFASV 183

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187405  79 EDLALVSGVGATKLEAIKLEICVssknsssnhspsslrkehehLP-CTGVNINTATPPQLMSV-RGITEKIAKNIVEFRS 156
Cdd:COG3156 184 SELRLVKGMTPELYARLAPYVTA--------------------LPgDTKINVNTAPPEVLAALlGGLSLDDAQALLAARP 243

                       170       180
                ....*....|....*....|....*....
gi 82187405 157 VhGPFKSIEDLVKVANINSSLLDRIRFQV 185
Cdd:COG3156 244 E-KGFADVADFLALLGLAGLDLLKDQLTV 271
HHH pfam00633
Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated ...
 42-68 1.52e-04

Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.


Pssm-ID: 425789 [Multi-domain]  Cd Length: 30  Bit Score: 38.94  E-value: 1.52e-04
                          10        20
                  ....*....|....*....|....*..
gi 82187405    42 NINTATEEELMTLPGVNRGVAQNIVEY 68
Cdd:pfam00633   4 GLIPASVEELLALPGVGPKTAEAILSY 30
T2SS_GspK NF037980
type II secretion system minor pseudopilin GspK;
78-191 3.48e-04

type II secretion system minor pseudopilin GspK;


Pssm-ID: 468299 [Multi-domain]  Cd Length: 311  Bit Score: 42.66  E-value: 3.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187405   78 VEDLALVSGVGATKLEAIKLEICVssknsssnhspsslrkehehLPCTG--VNINTATPPQLMSVR-GITEKIAKNIVEF 154
Cdd:NF037980 182 VSELRLVPGVTPALYARLRPYVCA--------------------LPTTTlaINVNTAPAEVLAALAaLLSLSQARALLAA 241

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 82187405  155 RSvHGPFKSIEDL--------VKVANINSSLLD------RIRFQVFVERSR 191
Cdd:NF037980 242 RP-AAGFRSVGDFlaqlalagLALDASDKEQLGvrsryfLLRGEVRLGEAR 291
polC PRK00448
DNA polymerase III PolC; Validated
 130-179 5.79e-04

DNA polymerase III PolC; Validated


Pssm-ID: 234767 [Multi-domain]  Cd Length: 1437  Bit Score: 42.90  E-value: 5.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 82187405   130 NTATPPqLMSVRGITEKIAKNIVEFRSvHGPFKSIEDLVKVANINSSLLD 179
Cdd:PRK00448 1369 DSLIPP-FNALPGLGENVAKSIVEARE-EGEFLSKEDLRKRTKVSKTLIE 1416
T2SSK pfam03934
Type II secretion system (T2SS), protein K; Members of this family are involved in the Type II ...
 78-179 1.61e-03

Type II secretion system (T2SS), protein K; Members of this family are involved in the Type II protein secretion system. The T2SK family includes proteins such as ExeK, PulK, OutX and XcpX.


Pssm-ID: 427597 [Multi-domain]  Cd Length: 283  Bit Score: 40.77  E-value: 1.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187405    78 VEDLALVSGVGATKLEAIKLEICVssknsssnhspsslrkehehLPC--TGVNINTATPPQLMS-VRGITEKIAKNIVEF 154
Cdd:pfam03934 155 VSELRLVLGFTPELYARLRPYVCA--------------------LPGdrTPINVNTAPAEVLAAlFDGLSLDQAQALLAQ 214

                          90       100
                  ....*....|....*....|....*
gi 82187405   155 RSVhGPFKSIEDLVKVANINSSLLD 179
Cdd:pfam03934 215 RPA-DGFESVDDFLAQPALGGGIAP 238
HHH_6 pfam14579
Helix-hairpin-helix motif; The HHH domain is a short DNA-binding domain.
 137-169 1.74e-03

Helix-hairpin-helix motif; The HHH domain is a short DNA-binding domain.


Pssm-ID: 434050 [Multi-domain]  Cd Length: 88  Bit Score: 37.45  E-value: 1.74e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 82187405   137 LMSVRGITEKIAKNIVEFRSvHGPFKSIEDLVK 169
Cdd:pfam14579  27 LGAIKGLGEAAAERIVEERE-NGPFKSLEDFAR 58
T2SS_GspK NF037980
type II secretion system minor pseudopilin GspK;
34-96 3.49e-03

type II secretion system minor pseudopilin GspK;


Pssm-ID: 468299 [Multi-domain]  Cd Length: 311  Bit Score: 39.58  E-value: 3.49e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 82187405   34 ILVNQERLNINTATEEELMTL-PGVNRGVAQNIVEYRDcIGGFKKVEDLALVSGVGATKLEAIK 96
Cdd:NF037980 206 LPTTTLAINVNTAPAEVLAALaALLSLSQARALLAARP-AAGFRSVGDFLAQLALAGLALDASD 268
DnaE COG0587
DNA polymerase III, alpha subunit [Replication, recombination and repair];
137-169 4.67e-03

DNA polymerase III, alpha subunit [Replication, recombination and repair];


Pssm-ID: 440352 [Multi-domain]  Cd Length: 1050  Bit Score: 40.05  E-value: 4.67e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 82187405  137 LMSVRGITEKIAKNIVEFRSVHGPFKSIEDLVK 169
Cdd:COG0587  817 LGAIKGVGEAAAEAIVAAREENGPFTSLFDFCR 849
HHH_5 pfam14520
Helix-hairpin-helix domain;
48-99 4.95e-03

Helix-hairpin-helix domain;


Pssm-ID: 434010 [Multi-domain]  Cd Length: 57  Bit Score: 35.54  E-value: 4.95e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187405    48 EEELMTLPGVNRGVAQNIVEyrdciGGFKKVEDLA--------LVSGVGATKLEAIKLEI 99
Cdd:pfam14520   1 FEELLSISGIGPKTALALLS-----AGIGTVEDLAeadvdelaEIPGIGEKTAQRIILEL 55
COG2374 COG2374
Predicted extracellular nuclease [General function prediction only];
419-524 5.09e-03

Predicted extracellular nuclease [General function prediction only];


Pssm-ID: 441941 [Multi-domain]  Cd Length: 362  Bit Score: 39.23  E-value: 5.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82187405 419 TLKGERDLLVMGHFGVAPDSSEMEILRKEKLsallapsvFTNISTRTPQGSR----------SLDNIWASRSLRKTYTGQ 488
Cdd:COG2374 249 AADPDAPVIVLGDFNDYPFEDPLRALLGAGG--------LTNLAEKLPAAERysyvydgnsgLLDHILVSPALAARVTGA 320

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 82187405 489 CSVV------REGLTNPWIPDNWSWGGvASEHCPVVAEFFLD 524
Cdd:COG2374 321 DIWHinadiyNDDFKPDFRTYADDPGR-ASDHDPVVVGLRLP 361
T2SSK pfam03934
Type II secretion system (T2SS), protein K; Members of this family are involved in the Type II ...
 40-96 7.41e-03

Type II secretion system (T2SS), protein K; Members of this family are involved in the Type II protein secretion system. The T2SK family includes proteins such as ExeK, PulK, OutX and XcpX.


Pssm-ID: 427597 [Multi-domain]  Cd Length: 283  Bit Score: 38.46  E-value: 7.41e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 82187405    40 RLNINTATEEELMTL-PGVNRGVAQNIVEYRDcIGGFKKVED---LALVSGVGATKLEAIK 96
Cdd:pfam03934 185 PINVNTAPAEVLAALfDGLSLDQAQALLAQRP-ADGFESVDDflaQPALGGGIAPSTAQLK 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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