PUTATIVE PSEUDOGENE: RecName: Full=Putative makorin-5; AltName: Full=Makorin ring finger protein pseudogene 6; AltName: Full=Makorin ring finger protein pseudogene 9; AltName: Full=Putative RING finger protein 65
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| MKRN1_C super family | cl24397 | E3 ubiquitin-protein ligase makorin, C-terminal; MKRN1_C is the very C-terminus of E3 ... |
1-33 | 1.84e-10 | ||
E3 ubiquitin-protein ligase makorin, C-terminal; MKRN1_C is the very C-terminus of E3 ubiquitin-protein ligase makorin-1, or MKRN1, a family of eukaryotic putative ribonucleoproteins with a distinctive array of zinc-finger motifs. MKRN1 plays an important role in modulating the homeostasis of telomere-length through a dynamic balance involving the stability of the protein hTERT. MKRN1 has been shown to be a a transcriptional co-regulator and an E3 ligase. It functions simultaneously as a differentially negative regulator of p53 and p21, preferentially leading cells to p53-dependent apoptosis by suppressing p21. The exact function of the C-terminal region has not been determined. The actual alignment was detected with superfamily member pfam15815: Pssm-ID: 464890 Cd Length: 87 Bit Score: 49.64 E-value: 1.84e-10
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| Name | Accession | Description | Interval | E-value | ||
| MKRN1_C | pfam15815 | E3 ubiquitin-protein ligase makorin, C-terminal; MKRN1_C is the very C-terminus of E3 ... |
1-33 | 1.84e-10 | ||
E3 ubiquitin-protein ligase makorin, C-terminal; MKRN1_C is the very C-terminus of E3 ubiquitin-protein ligase makorin-1, or MKRN1, a family of eukaryotic putative ribonucleoproteins with a distinctive array of zinc-finger motifs. MKRN1 plays an important role in modulating the homeostasis of telomere-length through a dynamic balance involving the stability of the protein hTERT. MKRN1 has been shown to be a a transcriptional co-regulator and an E3 ligase. It functions simultaneously as a differentially negative regulator of p53 and p21, preferentially leading cells to p53-dependent apoptosis by suppressing p21. The exact function of the C-terminal region has not been determined. Pssm-ID: 464890 Cd Length: 87 Bit Score: 49.64 E-value: 1.84e-10
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| Name | Accession | Description | Interval | E-value | ||
| MKRN1_C | pfam15815 | E3 ubiquitin-protein ligase makorin, C-terminal; MKRN1_C is the very C-terminus of E3 ... |
1-33 | 1.84e-10 | ||
E3 ubiquitin-protein ligase makorin, C-terminal; MKRN1_C is the very C-terminus of E3 ubiquitin-protein ligase makorin-1, or MKRN1, a family of eukaryotic putative ribonucleoproteins with a distinctive array of zinc-finger motifs. MKRN1 plays an important role in modulating the homeostasis of telomere-length through a dynamic balance involving the stability of the protein hTERT. MKRN1 has been shown to be a a transcriptional co-regulator and an E3 ligase. It functions simultaneously as a differentially negative regulator of p53 and p21, preferentially leading cells to p53-dependent apoptosis by suppressing p21. The exact function of the C-terminal region has not been determined. Pssm-ID: 464890 Cd Length: 87 Bit Score: 49.64 E-value: 1.84e-10
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