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Conserved domains on  [gi|75324353|sp|Q6NQP4|]
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RecName: Full=Leucine-rich repeat protein 2; Short=AtLRR2; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 30-183 6.02e-25

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 102.23  E-value: 6.02e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353   30 EGDALHALRRSLSDPDNVVQSWDPTlVNPCTWFHVTCNQHHQVTRLDLGNSNLSGHLVPELGKLEHLQYLELYKNEIQGT 109
Cdd:PLN00113  30 ELELLLSFKSSINDPLKYLSNWNSS-ADVCLWQGITCNNSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGP 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 75324353  110 IPSELGNL-KSLISLDLYNNNLTGKIPSslGKLKSLVFLRLNENRLTGPIPRELTVISSLKVVDVSGNDLCGTIP 183
Cdd:PLN00113 109 IPDDIFTTsSSLRYLNLSNNNFTGSIPR--GSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIP 181
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 30-183 6.02e-25

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 102.23  E-value: 6.02e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353   30 EGDALHALRRSLSDPDNVVQSWDPTlVNPCTWFHVTCNQHHQVTRLDLGNSNLSGHLVPELGKLEHLQYLELYKNEIQGT 109
Cdd:PLN00113  30 ELELLLSFKSSINDPLKYLSNWNSS-ADVCLWQGITCNNSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGP 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 75324353  110 IPSELGNL-KSLISLDLYNNNLTGKIPSslGKLKSLVFLRLNENRLTGPIPRELTVISSLKVVDVSGNDLCGTIP 183
Cdd:PLN00113 109 IPDDIFTTsSSLRYLNLSNNNFTGSIPR--GSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIP 181
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-178 7.43e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 7.43e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353  71 QVTRLDLGNSNLSgHLVPELGKLEHLQYLELYKNEIQgTIPSELGNLKSLISLDLYNNNLTGkIPSSLGKLKSLVFLRLN 150
Cdd:COG4886 114 NLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLTD-LPEELGNLTNLKELDLS 190

                        90       100
                ....*....|....*....|....*...
gi 75324353 151 ENRLTgPIPRELTVISSLKVVDVSGNDL 178
Cdd:COG4886 191 NNQIT-DLPEPLGNLTNLEELDLSGNQL 217
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 27-67 2.34e-10

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 53.84  E-value: 2.34e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 75324353    27 ANSEGDALHALRRSLSDPDNVVQSWDPTLVNPCTWFHVTCN 67
Cdd:pfam08263   1 LNDDGQALLAFKSSLNDPPGALSSWNSSSSDPCSWTGVTCD 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 70-155 4.43e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.07  E-value: 4.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353  70 HQVTRLDLGNSNLSGhlVPELGKLEHLQYLELYKNEIQgTIPSeLGNLKSLISLDLYNNNLTgKIPsSLGKLKSLVFLRL 149
Cdd:cd21340   2 KRITHLYLNDKNITK--IDNLSLCKNLKVLYLYDNKIT-KIEN-LEFLTNLTHLYLQNNQIE-KIE-NLENLVNLKKLYL 75


                ....*.
gi 75324353 150 NENRLT 155
Cdd:cd21340  76 GGNRIS 81
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 30-183 6.02e-25

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 102.23  E-value: 6.02e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353   30 EGDALHALRRSLSDPDNVVQSWDPTlVNPCTWFHVTCNQHHQVTRLDLGNSNLSGHLVPELGKLEHLQYLELYKNEIQGT 109
Cdd:PLN00113  30 ELELLLSFKSSINDPLKYLSNWNSS-ADVCLWQGITCNNSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGP 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 75324353  110 IPSELGNL-KSLISLDLYNNNLTGKIPSslGKLKSLVFLRLNENRLTGPIPRELTVISSLKVVDVSGNDLCGTIP 183
Cdd:PLN00113 109 IPDDIFTTsSSLRYLNLSNNNFTGSIPR--GSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIP 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-183 1.92e-23

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 97.61  E-value: 1.92e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353   75 LDLGNSNLSGHLVPELGKLEHLQYLELYKNEIQGTIPSELGNLKSLISLDLYNNNLTGKIPSSLGKLKSLVFLRLNENRL 154
Cdd:PLN00113 241 LDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNF 320

                         90       100
                 ....*....|....*....|....*....
gi 75324353  155 TGPIPRELTVISSLKVVDVSGNDLCGTIP 183
Cdd:PLN00113 321 TGKIPVALTSLPRLQVLQLWSNKFSGEIP 349
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-183 1.38e-22

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 95.30  E-value: 1.38e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353   75 LDLGNSNLSGHLVPELGKLEHLQYLELYKNEIQGTIPSELGNLKSLISLDLYNNNLTGKIPSSLGKLKSLVFLRLNENRL 154
Cdd:PLN00113 193 LTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKL 272

                         90       100
                 ....*....|....*....|....*....
gi 75324353  155 TGPIPRELTVISSLKVVDVSGNDLCGTIP 183
Cdd:PLN00113 273 SGPIPPSIFSLQKLISLDLSDNSLSGEIP 301
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 71-204 1.94e-22

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 94.91  E-value: 1.94e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353   71 QVTRLDLGNSNLSGHLVPELGKLEHLQYLELYKNEIQGTIPSELGNLKSLISLDLYNNNLTGKIPSSLGKLKSLVFLRLN 150
Cdd:PLN00113 476 RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLS 555

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 75324353  151 ENRLTGPIPRELTVISSLKVVDVSGNDLCGTIPVEGPFEHIPMQNFENNLRLEG 204
Cdd:PLN00113 556 QNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPSTGAFLAINASAVAGNIDLCG 609
PLN03150 PLN03150
hypothetical protein; Provisional
 33-183 5.04e-22

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 93.34  E-value: 5.04e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353   33 ALHALRRSLSDPDNVVQSWDPTLVNPCTWFHVTC-----NQHHQVTRLDLGNSNLSGHLVPELGKLEHLQYLELYKNEIQ 107
Cdd:PLN03150 376 ALQTLKSSLGLPLRFGWNGDPCVPQQHPWSGADCqfdstKGKWFIDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIR 455

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353  108 GTIPSELGNLKSLISLDLYNNNLTGKIPSSLGKLKSLVFLRLNENRLTGPIPRELTVI----SSLKVVDVSGndLCGtIP 183
Cdd:PLN03150 456 GNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGRllhrASFNFTDNAG--LCG-IP 532
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 77-209 7.08e-21

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 90.29  E-value: 7.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353   77 LGNSNLSGHLVPELGKLEHLQYLELYKNEIQGTIPSELGNLKSLISLDLYNNNLTGKIPSSLGKLKSLVFLRLNENRLTG 156
Cdd:PLN00113 219 LGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSG 298

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 75324353  157 PIPRELTVISSLKVVDVSGNDLCGTIPVegPFEHIP----MQNFENNLRLEGPELLG 209
Cdd:PLN00113 299 EIPELVIQLQNLEILHLFSNNFTGKIPV--ALTSLPrlqvLQLWSNKFSGEIPKNLG 353
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-184 5.80e-20

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.60  E-value: 5.80e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353   75 LDLGNSNLSGHLVPELGKLEHLQYLELYKNEIQGTIPSELGNLKSLISLDLYNNNLTGKIPSSLGKLKSLVFLRLNENRL 154
Cdd:PLN00113 145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL 224

                         90       100       110
                 ....*....|....*....|....*....|
gi 75324353  155 TGPIPRELTVISSLKVVDVSGNDLCGTIPV 184
Cdd:PLN00113 225 SGEIPYEIGGLTSLNHLDLVYNNLTGPIPS 254
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 71-200 3.47e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 82.59  E-value: 3.47e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353   71 QVTRLDLGNSNLSGHLvPELGKLEHLQYLELYKNEIQGTIPSELGNLKSLISLDLYNNNLTGKIPSSLGKLKSLVFLRLN 150
Cdd:PLN00113 453 SLQMLSLARNKFFGGL-PDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLS 531

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 75324353  151 ENRLTGPIPRELTVISSLKVVDVSGNDLCGTIPVE-GPFEHIPMQNFENNL 200
Cdd:PLN00113 532 HNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNlGNVESLVQVNISHNH 582
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-200 3.13e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 76.81  E-value: 3.13e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353   75 LDLGNSNLSGHLVPELGKLEHLQYLELYKNEIQGTIPSELGNLKSLISLDLYNNNLTGKIPSSLGKLKSLVFLRLNENRL 154
Cdd:PLN00113 313 LHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSL 392

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 75324353  155 TGPIPRELTVISSLKVVDVSGNDLCGTIPVEgpFEHIPMQNF----ENNL 200
Cdd:PLN00113 393 EGEIPKSLGACRSLRRVRLQDNSFSGELPSE--FTKLPLVYFldisNNNL 440
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-178 7.43e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 7.43e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353  71 QVTRLDLGNSNLSgHLVPELGKLEHLQYLELYKNEIQgTIPSELGNLKSLISLDLYNNNLTGkIPSSLGKLKSLVFLRLN 150
Cdd:COG4886 114 NLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLTD-LPEELGNLTNLKELDLS 190

                        90       100
                ....*....|....*....|....*...
gi 75324353 151 ENRLTgPIPRELTVISSLKVVDVSGNDL 178
Cdd:COG4886 191 NNQIT-DLPEPLGNLTNLEELDLSGNQL 217
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-182 2.30e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 74.11  E-value: 2.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353   75 LDLGNSNLSGHLVPELGKLEHLQYLELYKNEIQGTIPSELGNLKSLISLDLYNNNLTGKIPSSLGKLKSLVFLRLNENRL 154
Cdd:PLN00113 337 LQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSF 416

                         90       100
                 ....*....|....*....|....*...
gi 75324353  155 TGPIPRELTVISSLKVVDVSGNDLCGTI 182
Cdd:PLN00113 417 SGELPSEFTKLPLVYFLDISNNNLQGRI 444
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 74-183 1.70e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.80  E-value: 1.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353   74 RLDLGNSNLSGHLVPELGKLEHLQYLELYKNEIQGTIPSE-----------------LGNL------KSLISLDLYNNNL 130
Cdd:PLN00113 408 RVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRkwdmpslqmlslarnkfFGGLpdsfgsKRLENLDLSRNQF 487

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 75324353  131 TGKIPSSLGKLKSLVFLRLNENRLTGPIPRELTVISSLKVVDVSGNDLCGTIP 183
Cdd:PLN00113 488 SGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIP 540
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 68-183 5.10e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.26  E-value: 5.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353   68 QHHQVTRLDLGNSNLSGHLVPELGKLEHLQYLELYKNEIQGTIPSELGNLKSLISLDLYNNNLTGKIPSSLGKLKSLVFL 147
Cdd:PLN00113 354 KHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFL 433

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 75324353  148 RLNENRLTGPIPRELTVISSLKVVDVSGNDLCGTIP 183
Cdd:PLN00113 434 DISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLP 469
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 27-67 2.34e-10

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 53.84  E-value: 2.34e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 75324353    27 ANSEGDALHALRRSLSDPDNVVQSWDPTLVNPCTWFHVTCN 67
Cdd:pfam08263   1 LNDDGQALLAFKSSLNDPPGALSSWNSSSSDPCSWTGVTCD 41
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-178 1.81e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.70  E-value: 1.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353  73 TRLDLGNSNLSgHLVPELGKLEHLQYLELYKNEIQgTIPsELGNLKSLISLDLYNNNLTGkiPSSLGKLKSLVFLRLNEN 152
Cdd:COG4886 208 EELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLT-DLP-ELGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLDLSNN 282

                        90       100
                ....*....|....*....|....*.
gi 75324353 153 RLTGPIPRELTVISSLKVVDVSGNDL 178
Cdd:COG4886 283 QLTDLKLKELELLLGLNSLLLLLLLL 308
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
5-178 2.54e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.32  E-value: 2.54e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353   5 NSRRELLAASLILTLALIRLTEANSEGDALHALRRSLSDPDNVVQSWDPTLVNPCTWFHVTCNQHHQVTRLDLGNSNLSG 84
Cdd:COG4886   7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353  85 HLVPELGKLEHLQYLELYKNEiqgtipsELGNLKSLISLDLYNNNLTgKIPSSLGKLKSLVFLRLNENRLTgPIPRELTV 164
Cdd:COG4886  87 LGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT-DLPEPLGN 157

                       170
                ....*....|....
gi 75324353 165 ISSLKVVDVSGNDL 178
Cdd:COG4886 158 LTNLKSLDLSNNQL 171
LRR_8 pfam13855
Leucine rich repeat;
95-154 2.52e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 2.52e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353    95 HLQYLELYKNEIQGTIPSELGNLKSLISLDLYNNNLTGKIPSSLGKLKSLVFLRLNENRL 154
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
94-178 1.99e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 41.99  E-value: 1.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353   94 EHLQYLELYKNEIQgTIPSELGNlkSLISLDLYNNNLTGkIPSSLGklKSLVFLRLNENRLTGpIPRELTviSSLKVVDV 173
Cdd:PRK15370 283 EELRYLSVYDNSIR-TLPAHLPS--GITHLNVQSNSLTA-LPETLP--PGLKTLEAGENALTS-LPASLP--PELQVLDV 353


                 ....*
gi 75324353  174 SGNDL 178
Cdd:PRK15370 354 SKNQI 358
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 70-155 4.43e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.07  E-value: 4.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75324353  70 HQVTRLDLGNSNLSGhlVPELGKLEHLQYLELYKNEIQgTIPSeLGNLKSLISLDLYNNNLTgKIPsSLGKLKSLVFLRL 149
Cdd:cd21340   2 KRITHLYLNDKNITK--IDNLSLCKNLKVLYLYDNKIT-KIEN-LEFLTNLTHLYLQNNQIE-KIE-NLENLVNLKKLYL 75


                ....*.
gi 75324353 150 NENRLT 155
Cdd:cd21340  76 GGNRIS 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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