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Conserved domains on  [gi|81941545|sp|Q6GZX0|]
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RecName: Full=Uncharacterized protein 005R

Protein Classification

US22 domain-containing protein( domain architecture ID 10493272)

US22 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
US22 pfam02393
US22 like; US22 proteins have been found across many animal DNA viruses and some vertebrates. ...
 36-153 1.55e-33

US22 like; US22 proteins have been found across many animal DNA viruses and some vertebrates. The name sake of this family US22 is an early nuclear protein that is secreted from cells. The US22 family may have a role in virus replication and pathogenesis. Domain analysis showed that US22 proteins usually contain two copies of conserved modules which is homologous to several other families like SMI1 and SYD (commonly called SUKH superfamily). Bacterial operon analysis revealed that all bacterial SUKH members function as immunity proteins against various toxins. Thus US22 family is predicted to counter diverse anti-viral responses by interacting with specific host proteins.


:

Pssm-ID: 396802 [Multi-domain]  Cd Length: 124  Bit Score: 116.31  E-value: 1.55e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81941545    36 PGDLAVVSDFVKRNTGKRLPIGK--RSNLYVRICDLSGTIYMGETFILESWE-ELYLPEPTKMEVLGTLESCCGIPPFPE 112
Cdd:pfam02393   2 AADLEALRRFVRRHRGRLLPLGTpgPPGCTLRICPLEGTEYSGENARLEAWSlRLCCPEPVRLEVLGTVEDVEGMAPFPQ 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 81941545   113 WIVMVGEDQCVYAY--GDEEILLFAYSVKQLVEEGIQETGISY 153
Cdd:pfam02393  82 LVVLVGEFGRVYAYdpEDDELYRLADSLDEFFRVGLLRLETVY 124
 
Name Accession Description Interval E-value
US22 pfam02393
US22 like; US22 proteins have been found across many animal DNA viruses and some vertebrates. ...
 36-153 1.55e-33

US22 like; US22 proteins have been found across many animal DNA viruses and some vertebrates. The name sake of this family US22 is an early nuclear protein that is secreted from cells. The US22 family may have a role in virus replication and pathogenesis. Domain analysis showed that US22 proteins usually contain two copies of conserved modules which is homologous to several other families like SMI1 and SYD (commonly called SUKH superfamily). Bacterial operon analysis revealed that all bacterial SUKH members function as immunity proteins against various toxins. Thus US22 family is predicted to counter diverse anti-viral responses by interacting with specific host proteins.


Pssm-ID: 396802 [Multi-domain]  Cd Length: 124  Bit Score: 116.31  E-value: 1.55e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81941545    36 PGDLAVVSDFVKRNTGKRLPIGK--RSNLYVRICDLSGTIYMGETFILESWE-ELYLPEPTKMEVLGTLESCCGIPPFPE 112
Cdd:pfam02393   2 AADLEALRRFVRRHRGRLLPLGTpgPPGCTLRICPLEGTEYSGENARLEAWSlRLCCPEPVRLEVLGTVEDVEGMAPFPQ 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 81941545   113 WIVMVGEDQCVYAY--GDEEILLFAYSVKQLVEEGIQETGISY 153
Cdd:pfam02393  82 LVVLVGEFGRVYAYdpEDDELYRLADSLDEFFRVGLLRLETVY 124
 
Name Accession Description Interval E-value
US22 pfam02393
US22 like; US22 proteins have been found across many animal DNA viruses and some vertebrates. ...
 36-153 1.55e-33

US22 like; US22 proteins have been found across many animal DNA viruses and some vertebrates. The name sake of this family US22 is an early nuclear protein that is secreted from cells. The US22 family may have a role in virus replication and pathogenesis. Domain analysis showed that US22 proteins usually contain two copies of conserved modules which is homologous to several other families like SMI1 and SYD (commonly called SUKH superfamily). Bacterial operon analysis revealed that all bacterial SUKH members function as immunity proteins against various toxins. Thus US22 family is predicted to counter diverse anti-viral responses by interacting with specific host proteins.


Pssm-ID: 396802 [Multi-domain]  Cd Length: 124  Bit Score: 116.31  E-value: 1.55e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81941545    36 PGDLAVVSDFVKRNTGKRLPIGK--RSNLYVRICDLSGTIYMGETFILESWE-ELYLPEPTKMEVLGTLESCCGIPPFPE 112
Cdd:pfam02393   2 AADLEALRRFVRRHRGRLLPLGTpgPPGCTLRICPLEGTEYSGENARLEAWSlRLCCPEPVRLEVLGTVEDVEGMAPFPQ 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 81941545   113 WIVMVGEDQCVYAY--GDEEILLFAYSVKQLVEEGIQETGISY 153
Cdd:pfam02393  82 LVVLVGEFGRVYAYdpEDDELYRLADSLDEFFRVGLLRLETVY 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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