|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
1-464 |
0e+00 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 639.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 1 MENRCLPKKVPGFCSFRYGLAILLHFCNIVIMAQRVCLNLTMVAMVNKTEPPHLSNKSVAEMLDNVKNPVHSWSLDIQGL 80
Cdd:TIGR00894 1 MENVFASTKLPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENELDNIKNPNFKWSGALQGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 81 VLSSVFLGMVVIQVPVGYLSGAYPMEKIIGSSLFLSSVLSLLIPPAAQVGAALVIVCRVLQGIAQGAVSTGQHGIWVKWA 160
Cdd:TIGR00894 81 ILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 161 PPLERGRLTSMTLSGFVMGPFIALLVSGFICDL-LGWPMVFYIFGIVGCVLSLFWFILLFDDPNNHPYMSSSEKDYITSS 239
Cdd:TIGR00894 161 PPKERSRLLGMSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 240 LMQQVHSGRQSLPIKAMLKSLPLWAIILNSFAFIWSNNLLVTYTPTFISTTLHVNVRENGLLSSLPYLLAYICGIVAGQM 319
Cdd:TIGR00894 241 LQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 320 SDFLLSRKIFSVVAVRKLFTTLGIFCPVIFVVCLLYLSYNFYSTVIFLTLANSTLSFSFCGQLINALDIAPRYYGFLKAV 399
Cdd:TIGR00894 321 ADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGI 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2498059 400 TALIGIFGGLISSTLAGLILNQDPEYAWHKNFFLMAGINVTCLAFYLLFAKGDIQDWAKETKTTR 464
Cdd:TIGR00894 401 TGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKDTR 465
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
21-449 |
5.36e-132 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 386.59 E-value: 5.36e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 21 AILLHFCNIVIMAQRVCLNLTMVAMVNKTEPPHLSNKSVAEMLDNVKNPVHSWSLDIQGLVLSSVFLGMVVIQVPVGYLS 100
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTDKDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 101 GAYPMEKIIGSSLFLSSVLSLLIPPAAQVGAALVIVCRVLQGIAQGAVSTGQHGIWVKWAPPLERGRLTSMTLSGFVMGP 180
Cdd:cd17318 81 EKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 181 FIALLVSGFICDLLGWPMVFYIFGIVGCVLSLFWFILlfddpnnhpymsssekdyitsslmqqvhsgrqslpikamlkSL 260
Cdd:cd17318 161 VIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFL-----------------------------------------VL 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 261 PLWAIILNSFAFIWSNNLLVTYTPTFISTTLHVNVRENGLLSSLPYLLAYICGIVAGQMSDFLLSRKIFSVVAVRKLFTT 340
Cdd:cd17318 200 PVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRKLFTS 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 341 LGIFCPVIFVVCLLYLSYNFYSTVIFLTLANSTLSFSFCGQLINALDIAPRYYGFLKAVTALIGIFGGLISSTLAGLILN 420
Cdd:cd17318 280 IGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGAIVK 359
|
410 420 430
....*....|....*....|....*....|
gi 2498059 421 QD-PEYAWHKNFFLMAGINVTCLAFYLLFA 449
Cdd:cd17318 360 NDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
20-449 |
1.29e-85 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 268.19 E-value: 1.29e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 20 LAILLHFCNIVIMAQRVCLNLTMVAMVNKTEPPHLSNKSVA--------EMLDNVKNPVHSWSLDIQGLVLSSVFLGMVV 91
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNAcpehssspSVEHNETGKKYDWDAETQGWILGSFFYGYII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 92 IQVPVGYLSGAYPMEKIIGSSLFLSSVLSLLIPPAAQVGAALVIVCRVLQGIAQGAVSTGQHGIWVKWAPPLERGRLTSM 171
Cdd:cd17381 81 TQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 172 TLSGFVMGPFIALLVSGFICDLLGWPMVFYIFGIVGCVLSLFWFILLfddpnnhpymsssekdyitsslmqqvhsgrqsl 251
Cdd:cd17381 161 SYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV--------------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 252 pikamlksLPLWAIILNSFAFIWSNNLLVTYTPTFISTTLHVNVRENGLLSSLPYLLAYICGIVAGQMSDFLLSRKIFSV 331
Cdd:cd17381 208 --------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNFST 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 332 VAVRKLFTTLGIFCPVIFVVCLLYLSYNFYSTVIFLTLANSTLSFSFCGQLINALDIAPRYYGFLKAVTALIGIFGGLIS 411
Cdd:cd17381 280 VCVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPGMVG 359
|
410 420 430
....*....|....*....|....*....|....*...
gi 2498059 412 STLAGLILNQDPEYAWHKNFFLMAGINVTCLAFYLLFA 449
Cdd:cd17381 360 PVIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
21-449 |
2.25e-62 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 207.19 E-value: 2.25e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 21 AILLHFCNIVIMAQRVCLNLTMVAMVNKTEPPHlsnksvaEMLDNVKNPVHSWSLDIQGLVLSSVFLGMVVIQVPVGYLS 100
Cdd:cd17382 1 AIMAGLGFCISFGIRCNLGVAIVRMVNNFTDAY-------GGKVIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 101 GAYPMEKIIGSSLFLSSVLSLLIPPAAQVGAALVIVCRVLQGIAQGAVSTGQHGIWVKWAPPLERGRLTSMTLSGFVMGP 180
Cdd:cd17382 74 AKFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 181 FIALLVSGFICDLLGWPMVFYIFGIVGCVLSLFWfillfddpnnhpymsssekdyitsslmqqvhsgrqslpikaMLKSL 260
Cdd:cd17382 154 VVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFW-----------------------------------------MLVSM 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 261 PLWAIILNSFAFIWSNNLLVTYTPTFISTTLHVNVRENGLLSSLPYLLAYICGIVAGQMSDFLLSRKIFSVVAVRKLFTT 340
Cdd:cd17382 193 PVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNC 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 341 LGIFCPVIFVVCLLYlSYNFYSTVIFLTLANSTLSFSFCGQLINALDIAPRYYGFLKAVTALIGIFGGLISSTLAGLILN 420
Cdd:cd17382 273 GGFGMEATFLLVVAF-SHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTK 351
|
410 420
....*....|....*....|....*....
gi 2498059 421 QDPEYAWHKNFFLMAGINVTCLAFYLLFA 449
Cdd:cd17382 352 HKTREEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
72-449 |
2.59e-56 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 190.84 E-value: 2.59e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 72 SWSLDIQGLVLSSVFLGMVVIQVPVGYLSGAYPMEKIIGSSLFLSSVLSLLIPPAAQVGAALVIVCRVLQGIAQGAVSTG 151
Cdd:cd17380 30 GWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 152 QHGIWVKWAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMVFYIFGIVGCVLSLFWFILLfddpnnhpymsss 231
Cdd:cd17380 110 MTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 232 ekdyitsslmqqvhsgrqslpikamlksLPLWAIILNSFAFIWSNNLLVTYTPTFISTTLhVNVRENGLLSSLPYLLAYI 311
Cdd:cd17380 177 ----------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 312 CGIVAGQMSDFLLSRKiFSVVAVRKLFTTLGIFCPVIFVVCLLYLSyNFYSTVIFLTLANSTLSFSFCGQLINALDIAPR 391
Cdd:cd17380 228 SSNVAGWLADHLISRG-WTVTSVRKLMQSIGFLGPALFLLLLSHTD-SFSLALLCMSVALGLSAFSSSGVLVNHQDIAPN 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 2498059 392 YYGFLKAVTALIGIFGGLISSTLAGLILNQDPEyaWHKNFFLMAGINVTCLAFYLLFA 449
Cdd:cd17380 306 YAGIVFGISNTAGTIPGIVGVYLTGYILEATGS--WSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
78-447 |
2.20e-25 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 106.50 E-value: 2.20e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 78 QGLVLSSVFLGMVVIQVPVGYLSGAYPMEKIIGSSLFLSSVLSLLIppAAQVGAALVIVCRVLQGIAQGAVSTGQHGIWV 157
Cdd:cd17319 40 YGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALT--GFATSLTSLYVLRFLLGVAEAGFFPGAIKALA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 158 KWAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMVFYIFGIVGCVLSLFWFILLFDdpnnhpymsssekdyit 237
Cdd:cd17319 118 EWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ----------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 238 sslmqqvhsgrqslpikamlkslpLWAIILNSFAFIWSNNLLVTYTPTFISTTLHVNVRENGLLSSLPYLLAYICGIVAG 317
Cdd:cd17319 181 ------------------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 318 QMSDFLLSRKifsvvavRKLFTTLGIFCPVIFvVCLLYLSYNFYSTVIFLTLANSTLSFSFCGQLINALDIAPR-YYGFL 396
Cdd:cd17319 237 RLSDRLLRGA-------RRLVIIIGLLLAAVG-LLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeAAATA 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 2498059 397 KAVTALIGIFGGLISSTLAGLILNQdpEYAWHKNFFLMAGINVTCLAFYLL 447
Cdd:cd17319 309 GGLINSGGNLGGFVAPLLIGYLVDA--TGSYTAAFLFLAAVALLAALLVLL 357
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
79-450 |
1.07e-23 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 101.87 E-value: 1.07e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 79 GLVLSSVFLGMVVIQVPVGYLSGAYPMEKIIGSSLFLSSVLSLLIppAAQVGAALVIVCRVLQGIAQGAVSTGQHGIWVK 158
Cdd:COG2271 48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF--GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAE 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 159 WAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMVFYIFGIVGCVLSLFWFillfddpnnhpymsssekdyits 238
Cdd:COG2271 126 WFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRF----------------------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 239 slmqqvhsgrqslpikamlkslplWAIILNSFAFIWSNNLLVTYTPTFISTTLHVNVRENGLLSSLPYLLAYICGIVAGQ 318
Cdd:COG2271 183 ------------------------WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGW 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 319 MSDFLLSRkifsvvavRKLFTTLGIFCPVIFVVCLLYLSyNFYSTVIFLTLANSTLSFSFCGQLINALDIAP-RYYGFLK 397
Cdd:COG2271 239 LSDRLGRR--------RKLVLAIGLLLAALALLLLALLP-SPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTAS 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 2498059 398 AVTALIGIFGGLISSTLAGLILNQdpeYAWHKNFFLMAGINVTCLAFYLLFAK 450
Cdd:COG2271 310 GLVNTFGFLGGALGPLLVGYLLDA---TGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
73-412 |
2.38e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 91.71 E-value: 2.38e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 73 WSLDIQGLVLSSVFLGMVVIQVPVGYLSGAYPMEKIIGSSLFLSSVLSLLIPPAAQVgaALVIVCRVLQGIAQGAVSTGQ 152
Cdd:pfam07690 29 ISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL--WLLLVLRVLQGLGAGALFPAA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 153 HGIWVKWAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMVFYIFGIVGCVLSLFWFilLFDDPNNHPYMSSSE 232
Cdd:pfam07690 107 LALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL--LPRPPPESKRPKPAE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 233 KDYItsslmqqvhsgRQSLPIKAMLKSLPLWAIILnSFAFIWSNNLLVTYTPTFIsTTLHVNVRENGLLSSLPYLLAYIC 312
Cdd:pfam07690 185 EARL-----------SLIVAWKALLRDPVLWLLLA-LLLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 313 GIVAGQMSDFLLSRKIFsvvavrklftTLGIFCPVIFVVCLLYLSYNFYSTVIFLTLANSTLSFSFCGQLINAL---DIA 389
Cdd:pfam07690 252 RLLLGRLSDRLGRRRRL----------LLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALvsdLAP 321
|
330 340
....*....|....*....|...
gi 2498059 390 PRYYGFLKAVTALIGIFGGLISS 412
Cdd:pfam07690 322 KEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
73-446 |
1.46e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 87.10 E-value: 1.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 73 WSLDIQGLVLSSVFLGMVVIQVPVGYLSGAYPMEKIIGSSLFLSSVLSLLIPPAAQVgaALVIVCRVLQGIAQGAVSTGQ 152
Cdd:cd06174 28 LSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF--WLLLLGRFLLGLGSGLIDPAV 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 153 HGIWVKWAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLL--GWPMVFYIFGIVGCVLSLFWFILLFDDPNNHPYMSS 230
Cdd:cd06174 106 LALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 231 SEKdyitsslmqqvhSGRQSLPIKAMLKSLPLWAIILNSFAFIWSNNLLVTYTPTFISTTLHVNVRENGLLSSLPYLLAY 310
Cdd:cd06174 186 EAS------------SKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGA 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 311 ICGIVAGQMSDFLLSRKIFSVVavrklfttlGIFCPVIFVVCLLYLSYNFYSTVIFLTLANSTLSFSFCGQLINALDIAP 390
Cdd:cd06174 254 LGSLLLGLLSDRLIGRKPLLLI---------GLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPP 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 2498059 391 RYYGFLKAVTALIGIFGGLISSTLAGLILNQDpeYAWHKNFFLMAGINVTCLAFYL 446
Cdd:cd06174 325 EIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT--FGLTGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
73-386 |
5.84e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 78.86 E-value: 5.84e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 73 WSLDIQGLVLSSVFLGMVVIQVPVGYLSGAYPMEKIIGSSLFLSSVLSLLIPPAAQVGaaLVIVCRVLQGIAQGAVSTGQ 152
Cdd:COG2814 42 ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLW--LLLAARFLQGLGAGALFPAA 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 153 HGIWVKWAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMVFYIFGIVGCVLSLFWFILLfddPNNHPymssse 232
Cdd:COG2814 120 LALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLL---PESRP------ 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 233 kdyitsslmqqVHSGRQSLPIKAMLKSLPLWAIILNSFAFIWSNNLLVTYTPTFISTTLHVNVRENGLLSSLPYLLAYIC 312
Cdd:COG2814 191 -----------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLG 259
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2498059 313 GIVAGQMSDFLLSRKIFsvvavrklfttlgIFCPVIFVVCLLYLSYNFYSTVIFLTLANSTLSFSFCGQLINAL 386
Cdd:COG2814 260 ALLAGRLADRFGRRRLL-------------LIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQAL 320
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
132-448 |
9.72e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 75.69 E-value: 9.72e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 132 ALVIVCRVLQGIAQGAVSTGQHGIWVKWAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMVFYIFGIVGCVLS 211
Cdd:COG2223 94 WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVA 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 212 LFWFILLFDDPNNHPYMSssekdyiTSSLMQQvhsgrqslpiKAMLKSLPLWAIILNSFAFIWSNNLLVTYTPTFISTTL 291
Cdd:COG2223 174 VLAWLFLRDPPAGAAAAA-------KASLRDQ----------LEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQF 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 292 HVNVRENGLLSSLPYLLAYICGIVAGQMSDFLLSRKIFSVVAvrklfttlgifcpVIFVVCLLYLSYNFYSTVIFLTLAn 371
Cdd:COG2223 237 GLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVF-------------ALMALGLLLLALALGSLWLFLVLF- 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 372 stLSFSFCGQLINAL--DIAPRYYGfLKAVTALIGI------FGGLISSTLAGLILNQDPEYAWhkNFFLMAGINVTCLA 443
Cdd:COG2223 303 --LLLGLALGGGNGAvfALVPDIFP-TKNAGAVYGLvgaaggLGGFLGPLLFGALLDATGSYTA--AFLVFAVLALVALV 377
|
....*
gi 2498059 444 FYLLF 448
Cdd:COG2223 378 LTLLL 382
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
79-449 |
7.24e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 66.83 E-value: 7.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 79 GLVLSSVFLGMVVIQVPVGYLS---GAYPMeKIIGSSLFLSSVLSLLIppaAQVGAALVIVcRVLQGIAQGAVSTGQHGI 155
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSdrfGRKRL-LLLGLLLLAVSTLLFAF---ATSYWQLLLA-RFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 156 WVKWAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMVFYIFGIVGcVLSLFWFILLFDDPNNHPYmsssekdy 235
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA-LLALVLALLLLPEPRPPPN-------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 236 itsslMQQVHSGRQSLPIKAMLKSLPLWAIILNSFAFIWSNNLLVTYTPTFISTTLHVNVRENGLLSSLPYLLAYICGIV 315
Cdd:cd17325 180 -----KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPP 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 316 AGQMSDfLLSRKIFSVVAVrkLFTTLGIFcpvifvvcLLYLSYNFYSTVIFLTLAnsTLSFSFCGQLINAL--DIAPRY- 392
Cdd:cd17325 255 AGKLSD-RIGRKPLILIGL--LLSAVALL--------LLPLATSFWLLLLLLALL--GLGLGLVFPATLALlaDIVPPEg 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 2498059 393 YGFLKAVTALIGIFGGLISSTLAGLILNQdpeYAWHKNFFLMAGINVTCLAFYLLFA 449
Cdd:cd17325 322 RGTAMGLFNTAFSLGMVLGPLLGGFLYDA---FGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
135-419 |
4.64e-11 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 64.32 E-value: 4.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 135 IVCRVLQGIAQGAVSTGQHGIWVKWAPPLERGRLTSM-TLSGFVMGPFIALLVSGFICDLLGWPMVFYIFGIVGCVLSLF 213
Cdd:TIGR00881 87 AALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFwNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLI 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 214 WFILLFDDPNNhPYMSSSEKDYITSSLMQQVHSGRQSLPIKA----MLKSLPLWAIILNSFAFIWSNNLLVTYTPTFIST 289
Cdd:TIGR00881 167 CFLLLRDSPQS-CGLPPAEEMPNEEPDGDAEKKEEELTKKQIflqyVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQ 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 290 TLHVNVRENGLLSSLPYLLAYICGIVAGQMSDFLLSRKIFSVVAVRK---LFTTLGIFC-----PVIFVVCLLYLSYNFY 361
Cdd:TIGR00881 246 EKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMaliIVSLLVYWLnpaanPLMDLICLFALGFLVY 325
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 2498059 362 STVIFLTLANSTLSFSF-CGqlinaldiapryygflkAVTALIGIFGGLISStLAGLIL 419
Cdd:TIGR00881 326 GPQMLIGVIASELAPKKaAG-----------------TAAGFVGFFAYLGGI-LAGLPL 366
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
79-357 |
5.71e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 63.80 E-value: 5.71e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 79 GLVLSSVFLGMVVIQVPVGYLSGAYPMEKIIGSSLFLSSVLSLLIppAAQVGAALVIVCRVLQGIAQGAV-STGQHGIwV 157
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLM--ALVGSYPVLLVLLFLVGAGYGSVqPGGGRAI-M 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 158 KWAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMVFYIFGIVgCVLSLFWFILLFDDPNNHPYMSSSEKDYIT 237
Cdd:cd17475 111 RWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLV-SILAAVLFWLFYREPPAASAATESASTLLR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 238 SslmqqvhsgrqslpIKAMLKSLPLWAIILNSFAFIWSNNLLVTYTPTFISTTLHVNVRENGLLSSLPYLLAYICGIVAG 317
Cdd:cd17475 190 S--------------LKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLG 255
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2498059 318 QMSDFLLSRKifsvvavRKLFTTLGIFCPVIFVVCLLYLS 357
Cdd:cd17475 256 RVSDRVFGGR-------RRPVLVITAAIAAAALLVLSLLS 288
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
79-419 |
7.44e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 60.26 E-value: 7.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 79 GLVLSSVFLGMVVIQVPVGYLSGAYPMEKIIGSSLFLSSVLSLLIppAAQVGAALVIVCRVLQGIAQGAVSTGQHGIWVK 158
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA--ALAPSFALLLLARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 159 WAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMVFYIFGIVGCVLSLFWFILLFDDPNNHPYMSSSEKDYits 238
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSL--- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 239 slmqqvhsgrqslpiKAMLKSLPLWAIILNSFAFIWSNNLLVTYTPTFISTTLHVNVRENGLLsslpYLLAYICGIVAGQ 318
Cdd:cd17324 192 ---------------LLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGL----LLLFGVAGVVGSP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 319 msdfllsrkIFSVVAVRKLFTTLGIFCPVIFVVCLLYLSYNFYSTVIFLTLANSTLSFSFCGQLINA--LDIAPRYYGFL 396
Cdd:cd17324 253 ---------LAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTrvLRLAPEARGLA 323
|
330 340
....*....|....*....|...
gi 2498059 397 KAVTALIGIFGGLISSTLAGLIL 419
Cdd:cd17324 324 SSLYLAAYNLGGALGAALGGLVL 346
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
81-444 |
3.95e-09 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 58.41 E-value: 3.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 81 VLSSVF-LGMVVIQVPVGYLSGAYPMEKIIGSSLFLSSVLSLLIPpAAQVGAALVIVcRVLQGIAQGAVSTGQHGIWVKW 159
Cdd:cd17327 45 WGNTVFyVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTA-AVKNFGGLIAL-RFFLGLFESGVFPGFILYLGMW 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 160 APPLERG-RLTSMTLSGFVMGPFIALLVSGF-----ICDLLGWPMVFYIFGIVGCVLSLFWFILLFDDPNNHPYMSSSEK 233
Cdd:cd17327 123 YKREEQAkRIAFFYAAAGLGSIFGGLLAYGVfkilgVGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEK 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 234 DYITSSLMQ-QVHSGRQSLPIKAMLKSLPLWAIILNSFAFIWS---NNLLVTYTPTFISTTLHVNVRENgLLSSLPYLLA 309
Cdd:cd17327 203 ELAVERLRAnQTGKGDQKFKWKQIKEAFKDPRTWLLFLFFFCSqitNNGISNFLPLILKSLGFYSLQTN-LLSVPIGALG 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 310 YICGIVAGQMSDFLLSRKIFSVVAVrkLFTTLG----IFCPVIFV--VCLLYLSYNFYSTV-IFLTLANstlsfsfcgql 382
Cdd:cd17327 282 AVSLLIAALLSDRFKKRGLFAIFAC--VLALVGsiilLAAPNPPGayFAAYILGGGSYAGFpILLSWIS----------- 348
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2498059 383 inalDIAPRYYGflKAVTALIGIFGGLISSTLAGLIL--NQDPEYAWHKNFFLMAGINVTCLAF 444
Cdd:cd17327 349 ----SNCAGYTK--RATVLAIMLIFYNVGNIVAPQIFraGDAPRYIPGNIALLVCACVSIVLSV 406
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
74-325 |
3.10e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 51.74 E-value: 3.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 74 SLDIQGLVLSSVFLGMVVIQVPVGYLS---GAYPMeKIIGSSLFLSSVLSLLIPPaaqvGAALVIVCRVLQGIAQGAVST 150
Cdd:COG0477 47 SSAQLGWIVSAYLLGRAIGLLLFGRLGdryGRKRV-LLIGLLLFGLASLLCGLAP----SPELLIAARALQGIGAGGLMP 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 151 GQHGIWVKWAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMVFYIfgivGCVLSLFWFILLFDDPNNHPYMSS 230
Cdd:COG0477 122 GALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI----NAPLGLLALVLRLRLPESRGLLLA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 231 SEKDYITSSLMQQVHSGRQSLPIKAMLKSLPLWAIILNSFAFIWSNNLLVTYTPTFISTTLHVNVRENGLLSSLPYLLAY 310
Cdd:COG0477 198 LLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLA 277
|
250
....*....|....*
gi 2498059 311 ICGIVAGQMSDFLLS 325
Cdd:COG0477 278 LLLLLLLLLLLLLLA 292
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
125-447 |
6.92e-06 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 48.01 E-value: 6.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 125 PAAQVGAALVIVCRVLQGIAQGAVSTGQHGIWVKWAPPLERGRLTSM-----TLSGFVMGPFIALLVSGFICDllGWPMV 199
Cdd:cd17345 89 PSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIwnishNVGGGLVGPLAGLGLAIFGDG--WWRGA 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 200 FYIFGIVGCVLSLFWFILLFDDPNN------HPYMSSSEKDYITSSLMQQVhSGRQSLpIKAMLKSLPLWAIIL-NSFAF 272
Cdd:cd17345 167 FIFPAIIAIIVAVIVLFLGKDTPESeglppiEEYKGDYPEEADGEEEEQEL-SAWEIF-VKYVLKNKLLWYIAIaNVFVY 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 273 IWSNNLLvTYTPTFISTTLHVNVRENGLLSSLpYLLAYICG-IVAGQMSDfllsrkifsvvavrKLF----TTLGIFCPV 347
Cdd:cd17345 245 LVRYGIL-DWAPTYLSEVKGFSKAQAMWAFSL-FEWAAIPGtLLAGWLSD--------------KLFkgrrAPTGIIFMI 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 348 IFVVCLLYLSYNFYSTVIFLTLAnstlsfsFCGQLI---------NALDIAPRyygflKAV---TALIGIFGGLISSTLA 415
Cdd:cd17345 309 LVIVALIVYWLAPNVLVDLIALI-------ALGFLIygpvmliglQALELVPK-----KAAgtaAGLTGLFGYLGGSVLA 376
|
330 340 350
....*....|....*....|....*....|...
gi 2498059 416 GLILNQDPE-YAWHKNFFLMAGINVTCLAFYLL 447
Cdd:cd17345 377 TALIGIIVDhFGWNGGFIVLLASCILAIIFLAL 409
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
134-219 |
1.39e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 46.79 E-value: 1.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 134 VIVCRVLQGIAQGAVSTGQHGIWVKWAPPLERGRLTSMTLSGF----VMGPFIAllvsGFICDLLGWPMVFYI---FGIV 206
Cdd:cd17502 86 LIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFgiasVAGPLIG----GAFTDHLSWRWCFYInlpIGGL 161
|
90
....*....|....
gi 2498059 207 GCV-LSLFWFILLF 219
Cdd:cd17502 162 ALAlLRTILLSSIF 175
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
133-448 |
1.71e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.88 E-value: 1.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 133 LVIVCRVLQGIAQGAVSTGQHGIWVKWAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMVFYIFGIVGCVLSL 212
Cdd:cd17312 93 FFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAI 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 213 FWFILLFDDPnnhPYMsssekdyitsslmqqvhsgrqslpikamlkslplWAIILNSFAFIWSNNLLVTYTPTFISTTLH 292
Cdd:cd17312 173 ILFFFLRDSP---PYV----------------------------------WVLSLAYAFVYIVRYACLDWGPLYLYEVKG 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 293 VNVRENGLLSSLPYLLAYICGIVAGQMSDFLLSRkifsvvavRKLFTTLGIFCPVIFVVCLLYLS-YNFYSTVIFLTLAN 371
Cdd:cd17312 216 YSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGG--------RRAPIAVIYMLLMTLSLALFWFFpHNKLLSIVLLFLIG 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 372 STL--SFSFCGQLINAlDIAPRyyGFLKAVTALIGIFGGlISSTLAGLILNQ-DPEYAWHKNFFLMAGINVTCLAFYLLF 448
Cdd:cd17312 288 FFVggPINLIGGAAAQ-DIGRK--EAAGTATGFVGLFGY-LGASLAGLPLGYiIDHYGWSTVFYFLISAALLSVLLLLSL 363
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
126-219 |
3.78e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 43.41 E-value: 3.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 126 AAQVGAALV------IVCRVLQGIAQGAVSTGQHGIWVKWAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMV 199
Cdd:TIGR00880 40 LSTAMFALSsnitvlIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAP 119
|
90 100
....*....|....*....|
gi 2498059 200 FYIFGIvgcvLSLFWFILLF 219
Cdd:TIGR00880 120 FLFLAI----LALAAFILLA 135
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
70-218 |
7.36e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.86 E-value: 7.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 70 VHSWSLDIQGLVLSSVFLGMVVIQVPVGYLSGAYPMEKIIGSSLFLSSVLSLLIPPAAQVGAALVIVCRVLQGIAQGAVS 149
Cdd:COG2271 210 VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAF 289
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2498059 150 TGQHGIWVKWAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMVFYIFGIVGCVLSLFWFILL 218
Cdd:COG2271 290 GLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
79-217 |
8.82e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.53 E-value: 8.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 79 GLVLSSVFLGMVVIQVPVGYLSGAYPMEKIIGSSLFLSSVLSLLIppAAQVGAALVIVCRVLQGIAQGAVSTGQHGIWVK 158
Cdd:cd06173 247 GLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVL--GLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQL 324
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2498059 159 WAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMVFYIFGIVGCVLSLFWFIL 217
Cdd:cd06173 325 RVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
74-376 |
9.20e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.51 E-value: 9.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 74 SLDIQGLVLSSVFLGMVVIQVPVGYLSGAYPMEKIIGSSLFLSSVLSLLIppAAQVGAALVIVCRVLQGIAQGAVSTGQH 153
Cdd:cd17316 34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLI--GLLPTPILLLVLRFLQGIGIGGEYPGAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 154 GIWVKWAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLL----GWPMVFYIfGIVGCVLSLFWFILlfddpnnhpyms 229
Cdd:cd17316 112 TYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRILFLI-GALPALLALLLRRR------------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 230 ssekdyitsslmqqvhsgrqslpikamlkslpLWAIILNSFAFIWSNNLLVTYTPTFISTTLHVNVRENGLLSSLPYLLA 309
Cdd:cd17316 179 --------------------------------TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGA 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2498059 310 YICGIVAGQMSDFLLSRKIFSVVAvrklfttlgifcpVIFVVCLLYLSYNFYSTVIFLTLANSTLSF 376
Cdd:cd17316 227 LVGALIAGLLSDRIGRKKTLVIGL-------------ILSGILALPLFYLLSGSPTLLLLLLFILSF 280
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
130-210 |
1.91e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 43.70 E-value: 1.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 130 GAALVIVCRVLQGIAQGAVSTGQHGIWVKWAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMVFYIFGIVGCV 209
Cdd:cd17321 83 SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV 162
|
.
gi 2498059 210 L 210
Cdd:cd17321 163 A 163
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
74-448 |
5.35e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.20 E-value: 5.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 74 SLDIQGLVLSSVFLGMVVIQVPVGYLSGAYPMEKIIGSSLFLSSVLSLLIPPAAQVgaALVIVCRVLQGIAQGAVSTGQH 153
Cdd:cd17489 29 SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSV--ALLLVLRLIHGIGWGAFTTAAA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 154 GIWVKWAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMVFYIFGIVGCVLSLFWFILLFDDPNNHpymsssek 233
Cdd:cd17489 107 TLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAA-------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 234 dyitsslmqQVHSGRQSLPIKAMLKSLPLWAIILNSFAFIWSnnLLVTYTPTFISTTLHVNVrenGLLSSLPYLLAYICG 313
Cdd:cd17489 179 ---------EEAEAGTRAFRRLVEKKVLPPALILFLASIAYG--AISTFLPLYAAERGISNA---GLFFTVYAIALLLSR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 314 IVAGQMSDfllsrkifsvvavRKLFTTLGIFCPVIFVVCLLYLSYNFYSTVIFLTLANSTLSFS--FCGQLINALDIAPR 391
Cdd:cd17489 245 PFSGKLSD-------------RKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGllFPALQALAVDLVPP 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2498059 392 ---------YYGFLKAVTALIGIFGGLISSTLAGLILnqdpeyawhknFFLMAGINVTCLAFYLLF 448
Cdd:cd17489 312 hrrgaangtFFIFFDLGIGLGGLLLGLVAELFGYRAM-----------FLLAAVVVLLALVLYIFL 366
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
140-449 |
5.64e-04 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 41.94 E-value: 5.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 140 LQGIAQGAVSTGQHGIWVKWAPPLERGRL-----TSMTLSGFVmGPFIALLVSgficDLLGWPMVFYIFGIVGCVLSLFW 214
Cdd:cd17343 100 LNGLAQGLGWPPCAKILRKWFSPSQFGTWwsvlsTSMNLAGSL-GPILATLLA----LSYGWRSTLSISGTVAVVMSVVC 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 215 FILLFDDPNNhpymSSSEKDYITSSLMQQVHSGRQSLPIKAMLKSLPLWAIILNSFAFIWSNNLLVTYTPTFISTTLHVN 294
Cdd:cd17343 175 LLFIKNEPSD----VGLNNIEEEESKGKKKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFLIQDKGQS 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 295 VRENGLLSSLPYLLAYICGIVAGQMSDFLLSRKIFSVVAVRKLFTTLGIfcpVIFVVCLLYLSYNF---YSTVIFLTLAN 371
Cdd:cd17343 251 ALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSRGNPRMPLALVF---MAGLTVSLHLFRVHitsDSSELFILLLG 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 372 STLSFSFCGQL----INALDIAPRYY-GFLKAVTALIGIFGGLISSTLAGLILNQdpeYAWHKNFFLMagiNVTCLAFYL 446
Cdd:cd17343 328 FLIGFSLYGPIaifgVIANESAPSHLcGTSHAIVALAANVGGVLAGLPFSYIAKH---YDWRTAFLLL---EILCAITVV 401
|
...
gi 2498059 447 LFA 449
Cdd:cd17343 402 ILF 404
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
74-423 |
6.85e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.92 E-value: 6.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 74 SLDIQGLVLSSVFLGMVVIQVPVGYLSGAYPMEKIIGSSLFLSSVLSLLIPPAAQVgaALVIVCRVLQGIAQGAVSTGQh 153
Cdd:cd17333 29 NVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSI--YLFVVLMFLAGLGAGILDTGA- 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 154 GIWVKWAPPLERGRLTSMTLSGFVMGPFIA-LLVSGFICDLLGWPMVFYIFGIVGCVLSLFWFILLFddpnnhpymssse 232
Cdd:cd17333 106 NTFVGALFEESSATRLNVLHGFFGLGALIGpLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLF------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 233 kDYITSSLMQQVHSGRQSLPIKAMLKSLPLWAIILNSFAFIWSNNLLVTYTPTFISTTLHVNVRENGLlsslpyllayic 312
Cdd:cd17333 173 -PELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGY------------ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 313 gIVAGQMSDFLLSRKIFSVVAVRKLFTTLGIFCPVIFVVCLLYLSYNFYSTVIFLTLANSTLSFS--FCGQLINALDIAP 390
Cdd:cd17333 240 -LLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAalFPTILSLGISNLP 318
|
330 340 350
....*....|....*....|....*....|...
gi 2498059 391 RYYGFLKAVTALIGIFGGLISSTLAGLILNQDP 423
Cdd:cd17333 319 YAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVG 351
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
164-419 |
1.32e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.04 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 164 ERGRLTSM-----TLSGFVMGPFIALLVSGFICDL-LGWPMVFYIFGIVGCVLSLFWFILLfddpnnhpymssseKDYIT 237
Cdd:COG2211 144 ERTRLSSWrfafaGLGGLLASVLPPPLVAAFGGDAaLGYRLTALIFAVLGLLAFLLTFFGT--------------KERPV 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 238 SSlmQQVHSGRQSLpiKAMLKSLPLWAIILNSFAFIWSNNLLVTYTPTFISTTLHVNVRENGLLSSLpYLLAYICGIVAG 317
Cdd:COG2211 210 PE--EEKVSLKESL--KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLAL-YFLAALLGAPLW 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 318 QmsdfLLSRKIfsvvAVRKLFTTLGIFCPVIFVVCLLYLSYNFYSTVIFLTLANstLSFSFCGQLINAL--DIAP----- 390
Cdd:COG2211 285 P----RLAKRF----GKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAG--IGLGAILVLPWAMlaDVVDydewk 354
|
250 260 270
....*....|....*....|....*....|..
gi 2498059 391 ---RYYGFLKAVTALIGIFGGLISSTLAGLIL 419
Cdd:COG2211 355 tgrRREGLYFGIFTFAIKLGQALAGALAGLLL 386
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
135-223 |
1.86e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 40.25 E-value: 1.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 135 IVCRVLQGIAQGAVSTGQHGIWVKWAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMVFYI---FGIVGCVLS 211
Cdd:cd17503 88 IIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYInlpIGILALLLA 167
|
90
....*....|..
gi 2498059 212 LFWFILLFDDPN 223
Cdd:cd17503 168 PLLDLRLFKDRN 179
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
133-222 |
2.20e-03 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 40.44 E-value: 2.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 133 LVIVCRVLQGIAQGAVSTGQHGIWVKWAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMVFYIFGIVGC-VLS 211
Cdd:TIGR00711 92 LMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIiVVV 171
|
90
....*....|.
gi 2498059 212 LFWFILLFDDP 222
Cdd:TIGR00711 172 VAFFILPRDKP 182
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
265-448 |
4.31e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.32 E-value: 4.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 265 IILNSFAFIWSNNLLVTYTPTFISTTLHVNVRENGLLSSLPYLLAYICGIVAGQMSDFLLSRKIfsvvavrkLFTTLGIF 344
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRV--------LLIGLLLF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 345 CpviFVVCLLYLSYNFYSTVIFLTLANSTLSFSFCGQLINALDIAPR-YYGFLKAVTALIGIFGGLISSTLAGLILNQdp 423
Cdd:pfam07690 73 A---LGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASL-- 147
|
170 180
....*....|....*....|....*
gi 2498059 424 eYAWHKNFFLMAGINVTCLAFYLLF 448
Cdd:pfam07690 148 -FGWRAAFLILAILSLLAAVLLLLP 171
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
130-455 |
5.31e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 39.09 E-value: 5.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 130 GAALVIVCRVLQGIAQG---AVSTGqhgiWVKWAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMVFYIFGIV 206
Cdd:COG2807 105 SVALLLAGTALIGAGIAvgnVLLPG----LIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALL 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 207 GCVLSLFWFILLFDDPNNHPymsssekdyitsslmqqvhSGRQSLPIKAMLKSLPLWAIILNSFAFIWSNNLLVTYTPTF 286
Cdd:COG2807 181 ALLALLLWLPLLRRRPAAAA-------------------AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPI 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 287 IsTTLHVNVRENGLLSSlpylLAYICGIVAGQMSDFLLSRkifsVVAVRKLFTTLGIFCPVIFVVCLLYLSYNFYSTVIF 366
Cdd:COG2807 242 L-RDAGLSAATAGLLLS----LFQLAGIPGSLLVPLLADR----LGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVL 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 367 LTLANStLSFSFCGQLINALDIAPRYYGFLKAVTALIGIFGGLISSTLAGLILNQDPEYAWhkNFFLMAGINVTCLAFYL 446
Cdd:COG2807 313 LGLGQG-GLFPLALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTA--ALLLLAALAVLMLVAGL 389
|
....*....
gi 2498059 447 LFAKGDIQD 455
Cdd:COG2807 390 LAGRPYVED 398
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
123-186 |
6.19e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 38.66 E-value: 6.19e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2498059 123 IPPAAQVGAA---LVIVCRVLQGIAQGAVSTGQHGIWVKWAPPLERGRLTSMTLSGFVMGPFIALLV 186
Cdd:cd17369 94 LPTYAQIGILapiLLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGV 160
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
79-217 |
7.25e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 38.71 E-value: 7.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 79 GLVLSSVFLGMVVIQVPVGYLSGA-YPMEKIIGSSLFLSSVLSLLIPPAaqVGAALVIVCRVLQGIAQGAVSTGQHGIWV 157
Cdd:cd17474 237 GLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFV--PSLALLLIAIVLFGLGLGLNLPLLTTLVT 314
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 158 KWAPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPMVFYIFGIVGCVLSLFWFIL 217
Cdd:cd17474 315 ELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
126-219 |
7.57e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 38.33 E-value: 7.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2498059 126 AAQVGAALV------IVCRVLQGIAQGAV-STGQHGIWVKWaPPLERGRLTSMTLSGFVMGPFIALLVSGFICDLLGWPM 198
Cdd:cd17323 76 IFQIGCALApniamlIILRFLQGFFGSSPlAIGAGTIADLF-TPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRW 154
|
90 100
....*....|....*....|....
gi 2498059 199 VFYIFGIVGC---VLSLFWFILLF 219
Cdd:cd17323 155 IFWFLAIISGfclILIFLFLPIVL 178
|
|
| |
