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Conserved domains on  [gi|2501221|sp|Q61470|]
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RecName: Full=Leukocyte antigen CD37; AltName: CD_antigen=CD37

Protein Classification

tetraspanin family protein( domain architecture ID 13626516)

tetraspanin family protein similar to CD37 antigen (also known as tetraspanin-26), a transmembrane (TM) protein with four TM segments which may act as a molecular facilitator in diverse processes such as in the immune system, fusion, adhesion, migration to apoptosis, and alterations of cell morphology

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 108-243 1.39e-50

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


:

Pssm-ID: 239413  Cd Length: 117  Bit Score: 162.17  E-value: 1.39e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501221  108 ISTQRVRLERRVQELVLRTIQSYRTNPDETAAEESWDYAQFQLRCCGWQSPRDWNKaQMLKANeSEEPFVPCSCYNSTAT 187
Cdd:cd03160   1 IYFQRDKLKQEMGDIVEKVIQNYGGNPENKTAEEAWDYVQFQLQCCGWTGPQDWTD-NSLIKN-SSEPLYPCSCCNSSAT 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 2501221  188 NDStvfdklffsqlsrlgprakLRQTADICALPAK--AHIYREGCAQSLQKWLHNNII 243
Cdd:cd03160  79 ADS-------------------PRPSKGFCEAPASldWPVYQEGCMEKLQSWLNENLG 117
Tetraspanin pfam00335
Tetraspanin family;
26-268 9.98e-21

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 86.99  E-value: 9.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501221     26 GGLIFCFGTWILIDKTSFVSFVGLSFVPLQTwskVLAVSGVLTMALALLGCVGALKELRCLLGLYFGMLLLLFATQITLG 105
Cdd:pfam00335  16 GLLLLGVGVWLLSAFSLLLLGLSEASAYIPI---LLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAG 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501221    106 ILISTQRVRLERRVQELVLRTI-QSYRTNPD-ETAAEESWDYAQFQLRCCGwqsprdwnkaqmlkaneseepfvpcscyn 183
Cdd:pfam00335  93 ILAFVYRDKLSGLLSNWLKKSLeDGYRDWLDlYSCLNSALDSLQSEFGCCG----------------------------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501221    184 statndstvfdklffsqlsrlgpraklrqtadicalpakahiyreGCAQSLQKWLHNNIISIVGICLGVGLLELGFMTLS 263
Cdd:pfam00335 144 ---------------------------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILA 178


                  ....*
gi 2501221    264 IFLCR 268
Cdd:pfam00335 179 CCLCC 183
 
Name Accession Description Interval E-value
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 108-243 1.39e-50

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 162.17  E-value: 1.39e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501221  108 ISTQRVRLERRVQELVLRTIQSYRTNPDETAAEESWDYAQFQLRCCGWQSPRDWNKaQMLKANeSEEPFVPCSCYNSTAT 187
Cdd:cd03160   1 IYFQRDKLKQEMGDIVEKVIQNYGGNPENKTAEEAWDYVQFQLQCCGWTGPQDWTD-NSLIKN-SSEPLYPCSCCNSSAT 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 2501221  188 NDStvfdklffsqlsrlgprakLRQTADICALPAK--AHIYREGCAQSLQKWLHNNII 243
Cdd:cd03160  79 ADS-------------------PRPSKGFCEAPASldWPVYQEGCMEKLQSWLNENLG 117
Tetraspanin pfam00335
Tetraspanin family;
26-268 9.98e-21

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 86.99  E-value: 9.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501221     26 GGLIFCFGTWILIDKTSFVSFVGLSFVPLQTwskVLAVSGVLTMALALLGCVGALKELRCLLGLYFGMLLLLFATQITLG 105
Cdd:pfam00335  16 GLLLLGVGVWLLSAFSLLLLGLSEASAYIPI---LLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAG 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501221    106 ILISTQRVRLERRVQELVLRTI-QSYRTNPD-ETAAEESWDYAQFQLRCCGwqsprdwnkaqmlkaneseepfvpcscyn 183
Cdd:pfam00335  93 ILAFVYRDKLSGLLSNWLKKSLeDGYRDWLDlYSCLNSALDSLQSEFGCCG----------------------------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501221    184 statndstvfdklffsqlsrlgpraklrqtadicalpakahiyreGCAQSLQKWLHNNIISIVGICLGVGLLELGFMTLS 263
Cdd:pfam00335 144 ---------------------------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILA 178


                  ....*
gi 2501221    264 IFLCR 268
Cdd:pfam00335 179 CCLCC 183
 
Name Accession Description Interval E-value
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 108-243 1.39e-50

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 162.17  E-value: 1.39e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501221  108 ISTQRVRLERRVQELVLRTIQSYRTNPDETAAEESWDYAQFQLRCCGWQSPRDWNKaQMLKANeSEEPFVPCSCYNSTAT 187
Cdd:cd03160   1 IYFQRDKLKQEMGDIVEKVIQNYGGNPENKTAEEAWDYVQFQLQCCGWTGPQDWTD-NSLIKN-SSEPLYPCSCCNSSAT 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 2501221  188 NDStvfdklffsqlsrlgprakLRQTADICALPAK--AHIYREGCAQSLQKWLHNNII 243
Cdd:cd03160  79 ADS-------------------PRPSKGFCEAPASldWPVYQEGCMEKLQSWLNENLG 117
Tetraspanin pfam00335
Tetraspanin family;
26-268 9.98e-21

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 86.99  E-value: 9.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501221     26 GGLIFCFGTWILIDKTSFVSFVGLSFVPLQTwskVLAVSGVLTMALALLGCVGALKELRCLLGLYFGMLLLLFATQITLG 105
Cdd:pfam00335  16 GLLLLGVGVWLLSAFSLLLLGLSEASAYIPI---LLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAG 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501221    106 ILISTQRVRLERRVQELVLRTI-QSYRTNPD-ETAAEESWDYAQFQLRCCGwqsprdwnkaqmlkaneseepfvpcscyn 183
Cdd:pfam00335  93 ILAFVYRDKLSGLLSNWLKKSLeDGYRDWLDlYSCLNSALDSLQSEFGCCG----------------------------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501221    184 statndstvfdklffsqlsrlgpraklrqtadicalpakahiyreGCAQSLQKWLHNNIISIVGICLGVGLLELGFMTLS 263
Cdd:pfam00335 144 ---------------------------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILA 178


                  ....*
gi 2501221    264 IFLCR 268
Cdd:pfam00335 179 CCLCC 183
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 110-242 1.38e-12

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 62.14  E-value: 1.38e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501221  110 TQRVRLERRVQELVLRTIQSYRTNPDETAAeesWDYAQFQLRCCGWQSPRDWNKAQMLkaneseepfVPCSCYNSTATND 189
Cdd:cd03127   2 VYRDQLESLVSDTLNDAWDEYYVDDDFQEA---MDALQSTFECCGVNGPTDYLDLRLL---------VPSSCCKGTDGNC 69

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 2501221  190 StvfdklffsqlsrlgpraklrqtadicalpakAHIYREGCAQSLQKWLHNNI 242
Cdd:cd03127  70 G--------------------------------LNLYTEGCLEKLVDFLRSNL 90
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 114-245 5.60e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 46.70  E-value: 5.60e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501221  114 RLERRVQELVLRTIQSYRTNPDETAAeesWDYAQFQLRCCGWQSPRDWNKaqmlkaneseepFVPCSCyNSTATNDSTvf 193
Cdd:cd03164   6 KLNNYVKEGLTDSLEQYHKDNNTSEA---WDMIQSNLQCCGINGTTDWGS------------GVPSSC-CSSDTEYKV-- 67

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 2501221  194 dklffsqlsrlgpraklrqtadicalpakahiyrEGCAQSLQKWLHNNIISI 245
Cdd:cd03164  68 ----------------------------------EGCYKKLKNWFESNFLYT 85
penumbra_like_LEL cd03158
Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. ...
 117-242 9.88e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Human Penumbra exhibits growth-suppressive activity in vitro and has been associated with myeloid malignancies.


Pssm-ID: 239411  Cd Length: 119  Bit Score: 43.83  E-value: 9.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501221  117 RRVQELVLRTIQSYRTNPDETAAeesWDYAQFQLRCCGWQSPRDWNKAQMLKANES--EEPFVPCSCynSTATNDSTVFD 194
Cdd:cd03158   9 DLLEENIRKAIVHYYDDLDLQNI---IDFVQKEFKCCGGDDYRDWSKNMYFNCSSPnpEACGVPYSC--CIRAKDQEVIN 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 2501221  195 klffsqlSRLGPRAklrQTADicALPAKAHIYREGCAQSLQKWLHNNI 242
Cdd:cd03158  84 -------TMCGYGV---QNLE--RLEASKLIYTRGCIDAVVLWIEDNL 119
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 114-181 1.93e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 42.72  E-value: 1.93e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2501221  114 RLERRVQELVLRTIQSYRTNPDETAAEESWDYAQFQLRCCGWQSPRDWNKAQMLKANESEEPFVPCSC 181
Cdd:cd03155   6 QLEDELKESLKRTMQENYGQSGEEALTLTVDELQQEFKCCGSNNYTDWQDSEWINSNEANGRLVPDSC 73
TM4SF9_like_LEL cd03159
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. ...
 118-242 8.62e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 9 (TM4SF9) or Tetraspanin-5 and related proteins. TM4SF9 is strongly expressed witin the central nervous system, and expression levels appear to correlate with differentiation status of particular neurons, hinting at a role in neuronal maturation.


Pssm-ID: 239412 [Multi-domain]  Cd Length: 121  Bit Score: 41.26  E-value: 8.62e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2501221  118 RVQELVLRTIQSYRtnpDETAAEESWDYAQFQLRCCGWQSPRDWNKAQMLKANES----EEPFVPCSCY----NSTATND 189
Cdd:cd03159  10 QLTEFLNNNIRAYR---DDIDLQNLIDFLQEYWQCCGARGPDDWNLNIYFNCTDSnpsrERCGVPFSCCvkdpAEDVVNT 86

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 2501221  190 STVFDklffsqlsrlgPRAKLRqtadicaLPAKAHIYREGCAQSLQKWLHNNI 242
Cdd:cd03159  87 QCGYD-----------VRKKPE-------LELQHHIHTKGCVQAFEKWLQDNL 121
TM4SF8_like_LEL cd03163
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ...
 132-188 2.04e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration.


Pssm-ID: 239416  Cd Length: 105  Bit Score: 37.02  E-value: 2.04e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 2501221  132 TNPDETAAeeswDYAQFQLRCCGWQSPRDWNKAQMLKanESEEPFVPCSCYNSTATN 188
Cdd:cd03163  26 TNAESRAV----DYLQRQLQCCGIHNYTDWENTPWFK--ESKNNSVPLSCCKETFTS 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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