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Conserved domains on  [gi|30172804|sp|Q61164|]
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RecName: Full=Transcriptional repressor CTCF; AltName: Full=11-zinc finger protein; AltName: Full=CCCTC-binding factor; AltName: Full=CTCFL paralog

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 12159901)

C2H2-type zinc finger protein such as the transcriptional repressor CTCF, which is involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers

CATH:  3.30.160.60
Gene Symbol:  CTCF
Gene Ontology:  GO:0008270|GO:0003677|GO:0003700
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
366-500 3.26e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 3.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30172804 366 LKRHIRS--HTGE--RPFQC--SLCSYASRDTYKLKRHMRTHSGEKPYECYI--CHARFTQSGTMK---MHILQKHTENV 434
Cdd:COG5048 305 LTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNNEppqSLQQYKDLKND 384

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30172804 435 AKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKKCR--YCDAVFHERYALIQHQKSHKNEKRFKCDQC 500
Cdd:COG5048 385 KKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL 452
zf-H2C2_2 pfam13465
Zinc-finger double domain;
280-305 4.93e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 4.93e-05
                          10        20
                  ....*....|....*....|....*.
gi 30172804   280 NLDRHMKSHTDERPHKCHLCGRAFRT 305
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
509-534 1.37e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.37e-04
                          10        20
                  ....*....|....*....|....*.
gi 30172804   509 HMIMHKRTHTGEKPYACSHCDKTFRQ 534
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
309-333 3.68e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.68e-04
                          10        20
                  ....*....|....*....|....*
gi 30172804   309 LRNHLNTHTGTRPHKCPDCDMAFVT 333
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
351-375 7.94e-04

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 37.14  E-value: 7.94e-04
                          10        20
                  ....*....|....*....|....*
gi 30172804   351 FKCSMCDYASVEVSKLKRHIRSHTG 375
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
266-289 5.55e-03

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 34.83  E-value: 5.55e-03
                          10        20
                  ....*....|....*....|....
gi 30172804   266 FQCELCSYTCPRRSNLDRHMKSHT 289
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHT 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
366-500 3.26e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 3.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30172804 366 LKRHIRS--HTGE--RPFQC--SLCSYASRDTYKLKRHMRTHSGEKPYECYI--CHARFTQSGTMK---MHILQKHTENV 434
Cdd:COG5048 305 LTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNNEppqSLQQYKDLKND 384

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30172804 435 AKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKKCR--YCDAVFHERYALIQHQKSHKNEKRFKCDQC 500
Cdd:COG5048 385 KKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL 452
zf-H2C2_2 pfam13465
Zinc-finger double domain;
394-418 7.44e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 7.44e-06
                          10        20
                  ....*....|....*....|....*
gi 30172804   394 LKRHMRTHSGEKPYECYICHARFTQ 418
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
280-305 4.93e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 4.93e-05
                          10        20
                  ....*....|....*....|....*.
gi 30172804   280 NLDRHMKSHTDERPHKCHLCGRAFRT 305
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
509-534 1.37e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.37e-04
                          10        20
                  ....*....|....*....|....*.
gi 30172804   509 HMIMHKRTHTGEKPYACSHCDKTFRQ 534
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 468-500 1.61e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 40.62  E-value: 1.61e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 30172804 468 KCRYCDAVFHERYALIQHQKShkneKRFKCDQC 500
Cdd:cd20908   3 WCYYCDREFDDEKILIQHQKA----KHFKCHIC 31
zf-H2C2_2 pfam13465
Zinc-finger double domain;
309-333 3.68e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.68e-04
                          10        20
                  ....*....|....*....|....*
gi 30172804   309 LRNHLNTHTGTRPHKCPDCDMAFVT 333
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
351-375 7.94e-04

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 37.14  E-value: 7.94e-04
                          10        20
                  ....*....|....*....|....*
gi 30172804   351 FKCSMCDYASVEVSKLKRHIRSHTG 375
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
266-289 5.55e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 34.83  E-value: 5.55e-03
                          10        20
                  ....*....|....*....|....
gi 30172804   266 FQCELCSYTCPRRSNLDRHMKSHT 289
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHT 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
366-500 3.26e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 3.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30172804 366 LKRHIRS--HTGE--RPFQC--SLCSYASRDTYKLKRHMRTHSGEKPYECYI--CHARFTQSGTMK---MHILQKHTENV 434
Cdd:COG5048 305 LTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNNEppqSLQQYKDLKND 384

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30172804 435 AKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKKCR--YCDAVFHERYALIQHQKSHKNEKRFKCDQC 500
Cdd:COG5048 385 KKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL 452
zf-H2C2_2 pfam13465
Zinc-finger double domain;
394-418 7.44e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 7.44e-06
                          10        20
                  ....*....|....*....|....*
gi 30172804   394 LKRHMRTHSGEKPYECYICHARFTQ 418
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
280-305 4.93e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 4.93e-05
                          10        20
                  ....*....|....*....|....*.
gi 30172804   280 NLDRHMKSHTDERPHKCHLCGRAFRT 305
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
509-534 1.37e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.37e-04
                          10        20
                  ....*....|....*....|....*.
gi 30172804   509 HMIMHKRTHTGEKPYACSHCDKTFRQ 534
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 468-500 1.61e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 40.62  E-value: 1.61e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 30172804 468 KCRYCDAVFHERYALIQHQKShkneKRFKCDQC 500
Cdd:cd20908   3 WCYYCDREFDDEKILIQHQKA----KHFKCHIC 31
zf-H2C2_2 pfam13465
Zinc-finger double domain;
366-387 2.37e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.37e-04
                          10        20
                  ....*....|....*....|..
gi 30172804   366 LKRHIRSHTGERPFQCSLCSYA 387
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-428 3.08e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 3.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30172804 265 TFQC--ELCSYTCPRRSNLDRHMKSHTDERPHKCHlcgrafrtvtlLRNHLNTHTGtrphkcpdcdmAFVTSGELVRHRR 342
Cdd:COG5048 321 PFSCpySLCGKLFSRNDALKRHILLHTSISPAKEK-----------LLNSSSKFSP-----------LLNNEPPQSLQQY 378

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30172804 343 YKHTHEKPFKCSM--CDYASVEVSKLKRHIRSHTGERP--FQCSLCSYASRDTYKLKRHMRTHSgEKPYECYICHARFTQ 418
Cdd:COG5048 379 KDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRR 457

                       170
                ....*....|
gi 30172804 419 SGTMKMHILQ 428
Cdd:COG5048 458 DLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
309-333 3.68e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.68e-04
                          10        20
                  ....*....|....*....|....*
gi 30172804   309 LRNHLNTHTGTRPHKCPDCDMAFVT 333
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
290-573 4.35e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 4.35e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30172804 290 DERPHKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCPD--CDMAFVTSGELVRHRRYKHTHeKPFKCSMCDYAS-VEVSKL 366
Cdd:COG5048  30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNN-PSDLNSKSLPLSnSKASSS 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30172804 367 KRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARF--------TQSGTMKMHILQKHTENVAKFH 438
Cdd:COG5048 109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnsLHPPLPANSLSKDPSSNLSLLI 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30172804 439 CP--HCDTVIARKSDLGVHLRK-QHSYIEQGK-------KCRYCDAVFHERYALIQHQKSHKNEKRFKCDQCDYACRQER 508
Cdd:COG5048 189 SSnvSTSIPSSSENSPLSSSYSiPSSSSDQNLensssslPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30172804 509 HMIMHKRTHTGE-------KPYACSHCDKTFRQKQLLDMHFKRYHDPNFVPAAFVC--SKCGKTFTRRNTMARH 573
Cdd:COG5048 269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCpySLCGKLFSRNDALKRH 342
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
351-375 7.94e-04

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 37.14  E-value: 7.94e-04
                          10        20
                  ....*....|....*....|....*
gi 30172804   351 FKCSMCDYASVEVSKLKRHIRSHTG 375
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
DiS_P_DiS pfam06750
Bacterial Peptidase A24 N-terminal domain; This family is found at the N-terminus of the ...
 438-483 4.30e-03

Bacterial Peptidase A24 N-terminal domain; This family is found at the N-terminus of the pre-pilin peptidases (pfam01478). It's function has not been specifically determined; however some of the family have been characterized as bifunctional, and this domain may contain the N-methylation activity (EC:2.1.1.-). It consists of an intracellular region between a pair of transmembrane. This region contains an invariant proline and two almost fully conserved disulphide bridges - hence the name DiS-P-DiS. The cysteines have been shown to be essential to the overall function of the enzyme in, but their role was incorrectly ascribed.


Pssm-ID: 462001  Cd Length: 84  Bit Score: 36.65  E-value: 4.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 30172804   438 HCPHCDTVIaRKSDLGVHLrkqhSYIEQGKKCRYCDAVFHERYALI 483
Cdd:pfam06750  29 HCPSCGHRL-RWYDNIPVL----SWLLLRGRCRYCGAKISIRYPLV 69
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
266-289 5.55e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 34.83  E-value: 5.55e-03
                          10        20
                  ....*....|....*....|....
gi 30172804   266 FQCELCSYTCPRRSNLDRHMKSHT 289
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHT 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
481-506 7.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.59e-03
                          10        20
                  ....*....|....*....|....*.
gi 30172804   481 ALIQHQKSHKNEKRFKCDQCDYACRQ 506
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SF2_C_priA cd18804
C-terminal helicase domain of ATP-dependent helicase PriA; PriA, also known as replication ...
 265-335 8.14e-03

C-terminal helicase domain of ATP-dependent helicase PriA; PriA, also known as replication factor Y or primosomal protein N', is a 3'-->5' DNA helicase that acts to remodel stalled replication forks and as a specificity factor for origin-independent assembly of a new replisome at the stalled fork. PriA is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350191 [Multi-domain]  Cd Length: 238  Bit Score: 38.77  E-value: 8.14e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30172804 265 TFQCELCSYTcPRRSNLDRHMKSHTDERPHKCHLCGRAFRTvtllrnhlnthtgtrPHKCPDC---DMAFVTSG 335
Cdd:cd18804  45 SVLCRDCGYV-PECPNCDVSMTYHKSTNKLKCHYCGYQEPI---------------PKQCPECgseDLVFKGIG 102
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 294-316 9.55e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 9.55e-03
                          10        20
                  ....*....|....*....|...
gi 30172804   294 HKCHLCGRAFRTVTLLRNHLNTH 316
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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