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Conserved domains on  [gi|81883711|sp|Q5XI74|]
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RecName: Full=Endonuclease/exonuclease/phosphatase family domain-containing protein 1

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MnuA_DNase1-like cd10283
Mycoplasma pulmonis MnuA nuclease-like; This subfamily includes Mycoplasma pulmonis MnuA, a ...
 261-538 3.75e-50

Mycoplasma pulmonis MnuA nuclease-like; This subfamily includes Mycoplasma pulmonis MnuA, a membrane-associated nuclease related to Deoxyribonuclease 1 (DNase1 or DNase I, EC 3.1.21.1). The in vivo role of MnuA is as yet undetermined. This subfamily belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.


:

Pssm-ID: 197338 [Multi-domain]  Cd Length: 266  Bit Score: 173.74  E-value: 3.75e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711 261 FRLATWNLQ--GCSVEKANNPGVREVVCMTLLensiKLLAVQELLDK----EALEKFCTELNQPilpnirkwkgpRGCWR 334
Cdd:cd10283   1 LRIASWNILnfGNSKGKEKNPAIAEIISAFDL----DLIALQEVMDNggglDALAKLVNELNKP-----------GGTWK 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711 335 SIVAEKPSSQLQKGPCYsGFLWDTAANVelrdIPGQESSPSNGHAKTVGPSPFLARFKVG--SNDLTLVNLQLTALALPG 412
Cdd:cd10283  66 YIVSDKTGGSSGDKERY-AFLYKSSKVR----KVGKAVLEKDSNTDGFARPPYAAKFKSGgtGFDFTLVNVHLKSGGSSK 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711 413 VENSSKNHSDGHRLLNFALTLqETLKGEKDVVILGDFGQGPDSSDYDILRREKFHHLIPAhtFTNISTRNPQGSKSVDNI 492
Cdd:cd10283 141 SGQGAKRVAEAQALAEYLKEL-ADEDPDDDVILLGDFNIPADEDAFKALTKAGFKSLLPD--STNLSTSFKGYANSYDNI 217

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 81883711 493 WISKSLK------KVFTGHWAVVREGLTnpwIPDNWSWGGVASEHCPVLAEL 538
Cdd:cd10283 218 FVSGNLKekfsnsGVFDFNILVDEAGEE---DLDYSKWRKQISDHDPVWVEF 266
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 127-195 1.48e-22

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


:

Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 91.46  E-value: 1.48e-22
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81883711 127 LATTVPLTPRVNINTATLAQLMSVRGLSEKMAVSIVDYRREHGPFRSVEDLVRMDGINAAFLDRIRHQV 195
Cdd:COG1555   3 ASASAAAGGKVDINTATAEELQTLPGIGPKLAQRIVEYREKNGPFKSVEDLLEVKGIGPKTLEKLKPYL 71
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 38-95 2.35e-21

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


:

Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 88.00  E-value: 2.35e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 81883711  38 ERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVK 95
Cdd:COG1555  11 GKVDINTATAEELQTLPGIGPKLAQRIVEYREKNGPFKSVEDLLEVKGIGPKTLEKLK 68
 
Name Accession Description Interval E-value
MnuA_DNase1-like cd10283
Mycoplasma pulmonis MnuA nuclease-like; This subfamily includes Mycoplasma pulmonis MnuA, a ...
 261-538 3.75e-50

Mycoplasma pulmonis MnuA nuclease-like; This subfamily includes Mycoplasma pulmonis MnuA, a membrane-associated nuclease related to Deoxyribonuclease 1 (DNase1 or DNase I, EC 3.1.21.1). The in vivo role of MnuA is as yet undetermined. This subfamily belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.


Pssm-ID: 197338 [Multi-domain]  Cd Length: 266  Bit Score: 173.74  E-value: 3.75e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711 261 FRLATWNLQ--GCSVEKANNPGVREVVCMTLLensiKLLAVQELLDK----EALEKFCTELNQPilpnirkwkgpRGCWR 334
Cdd:cd10283   1 LRIASWNILnfGNSKGKEKNPAIAEIISAFDL----DLIALQEVMDNggglDALAKLVNELNKP-----------GGTWK 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711 335 SIVAEKPSSQLQKGPCYsGFLWDTAANVelrdIPGQESSPSNGHAKTVGPSPFLARFKVG--SNDLTLVNLQLTALALPG 412
Cdd:cd10283  66 YIVSDKTGGSSGDKERY-AFLYKSSKVR----KVGKAVLEKDSNTDGFARPPYAAKFKSGgtGFDFTLVNVHLKSGGSSK 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711 413 VENSSKNHSDGHRLLNFALTLqETLKGEKDVVILGDFGQGPDSSDYDILRREKFHHLIPAhtFTNISTRNPQGSKSVDNI 492
Cdd:cd10283 141 SGQGAKRVAEAQALAEYLKEL-ADEDPDDDVILLGDFNIPADEDAFKALTKAGFKSLLPD--STNLSTSFKGYANSYDNI 217

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 81883711 493 WISKSLK------KVFTGHWAVVREGLTnpwIPDNWSWGGVASEHCPVLAEL 538
Cdd:cd10283 218 FVSGNLKekfsnsGVFDFNILVDEAGEE---DLDYSKWRKQISDHDPVWVEF 266
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 127-195 1.48e-22

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 91.46  E-value: 1.48e-22
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81883711 127 LATTVPLTPRVNINTATLAQLMSVRGLSEKMAVSIVDYRREHGPFRSVEDLVRMDGINAAFLDRIRHQV 195
Cdd:COG1555   3 ASASAAAGGKVDINTATAEELQTLPGIGPKLAQRIVEYREKNGPFKSVEDLLEVKGIGPKTLEKLKPYL 71
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 38-95 2.35e-21

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 88.00  E-value: 2.35e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 81883711  38 ERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVK 95
Cdd:COG1555  11 GKVDINTATAEELQTLPGIGPKLAQRIVEYREKNGPFKSVEDLLEVKGIGPKTLEKLK 68
HHH_3 pfam12836
Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.
 37-95 5.92e-19

Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.


Pssm-ID: 463723 [Multi-domain]  Cd Length: 62  Bit Score: 80.60  E-value: 5.92e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 81883711    37 QERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVK 95
Cdd:pfam12836   1 AVGVDINTASAELLSRVPGLGPKLAKNIVEYREENGPFRSREDLLKVKGLGPKTFEQLA 59
HHH_3 pfam12836
Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.
 136-195 2.13e-18

Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.


Pssm-ID: 463723 [Multi-domain]  Cd Length: 62  Bit Score: 79.06  E-value: 2.13e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711   136 RVNINTATLAQLMSVRGLSEKMAVSIVDYRREHGPFRSVEDLVRMDGINAAFLDRIRHQV 195
Cdd:pfam12836   3 GVDINTASAELLSRVPGLGPKLAKNIVEYREENGPFRSREDLLKVKGLGPKTFEQLAGFL 62
comE TIGR01259
comEA protein; This model describes the ComEA protein in bacteria. The com E locus is ...
 40-100 2.01e-13

comEA protein; This model describes the ComEA protein in bacteria. The com E locus is obligatory for bacterial cell competence - the process of internalizing the exogenous added DNA. Lesions in the loci has been variously described for the appearance of competence-related pheonotypes and impairment of competence, suggesting their intimate functional role in bacterial transformation. [Cellular processes, DNA transformation]


Pssm-ID: 213597 [Multi-domain]  Cd Length: 120  Bit Score: 66.85  E-value: 2.01e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81883711    40 LNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVKFEICV 100
Cdd:TIGR01259  60 VNINAASLEELQALPGIGPAKAKAIIEYREENGAFKSVDDLTKVSGIGEKSLEKLKDYATV 120
comE TIGR01259
comEA protein; This model describes the ComEA protein in bacteria. The com E locus is ...
 137-195 5.49e-12

comEA protein; This model describes the ComEA protein in bacteria. The com E locus is obligatory for bacterial cell competence - the process of internalizing the exogenous added DNA. Lesions in the loci has been variously described for the appearance of competence-related pheonotypes and impairment of competence, suggesting their intimate functional role in bacterial transformation. [Cellular processes, DNA transformation]


Pssm-ID: 213597 [Multi-domain]  Cd Length: 120  Bit Score: 63.00  E-value: 5.49e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 81883711   137 VNINTATLAQLMSVRGLSEKMAVSIVDYRREHGPFRSVEDLVRMDGINAAFLDRIRHQV 195
Cdd:TIGR01259  60 VNINAASLEELQALPGIGPAKAKAIIEYREENGAFKSVDDLTKVSGIGEKSLEKLKDYA 118
COG2374 COG2374
Predicted extracellular nuclease [General function prediction only];
426-542 5.32e-05

Predicted extracellular nuclease [General function prediction only];


Pssm-ID: 441941 [Multi-domain]  Cd Length: 362  Bit Score: 45.78  E-value: 5.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711 426 LLNFALTLQeTLKGEKDVVILGDFGQGPDSSDYDILRREK-FHHLIPAHTFTNISTRNPQGSKSV-DNIWISKSLKKVFT 503
Cdd:COG2374 240 LRAFVDSLL-AADPDAPVIVLGDFNDYPFEDPLRALLGAGgLTNLAEKLPAAERYSYVYDGNSGLlDHILVSPALAARVT 318

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 81883711 504 G--HW----AVVREGLTNPWIPDNWSWGGvASEHCPVLAELYMEK 542
Cdd:COG2374 319 GadIWhinaDIYNDDFKPDFRTYADDPGR-ASDHDPVVVGLRLPP 362
T2SS_GspK NF037980
type II secretion system minor pseudopilin GspK;
33-95 1.77e-04

type II secretion system minor pseudopilin GspK;


Pssm-ID: 468299 [Multi-domain]  Cd Length: 311  Bit Score: 43.82  E-value: 1.77e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81883711   33 ILVNQERLNINTATEEELMTL-PGVTRAVARSIVEYREYiGGFKKVEDLALVSGVGATKLEQVK 95
Cdd:NF037980 206 LPTTTLAINVNTAPAEVLAALaALLSLSQARALLAARPA-AGFRSVGDFLAQLALAGLALDASD 268
T2SS_GspK NF037980
type II secretion system minor pseudopilin GspK;
109-195 5.15e-04

type II secretion system minor pseudopilin GspK;


Pssm-ID: 468299 [Multi-domain]  Cd Length: 311  Bit Score: 42.28  E-value: 5.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711  109 HSPSSLRR------DLLAEQQPHhlATTVP-LTPRVNINTATLAQLMSVR-GLSEKMAVSIVDyRREHGPFRSVEDL--- 177
Cdd:NF037980 180 ADVSELRLvpgvtpALYARLRPY--VCALPtTTLAINVNTAPAEVLAALAaLLSLSQARALLA-ARPAAGFRSVGDFlaq 256

                         90
                 ....*....|....*...
gi 81883711  178 VRMDGINAAFLDRIRHQV 195
Cdd:NF037980 257 LALAGLALDASDKEQLGV 274
dnaE2 PRK05672
error-prone DNA polymerase; Validated
 133-189 7.21e-04

error-prone DNA polymerase; Validated


Pssm-ID: 235553 [Multi-domain]  Cd Length: 1046  Bit Score: 42.54  E-value: 7.21e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 81883711   133 LTPRVNINTATLAQLMSVRGLSEKMAVSIVDyRREHGPFRSVEDLVRMDGINAAFLD 189
Cdd:PRK05672  804 LEPLPDGGPAVRLGLRLVRGLGEEAAERIVA-ARARGPFTSVEDLARRAGLDRRQLE 859
 
Name Accession Description Interval E-value
MnuA_DNase1-like cd10283
Mycoplasma pulmonis MnuA nuclease-like; This subfamily includes Mycoplasma pulmonis MnuA, a ...
 261-538 3.75e-50

Mycoplasma pulmonis MnuA nuclease-like; This subfamily includes Mycoplasma pulmonis MnuA, a membrane-associated nuclease related to Deoxyribonuclease 1 (DNase1 or DNase I, EC 3.1.21.1). The in vivo role of MnuA is as yet undetermined. This subfamily belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds.


Pssm-ID: 197338 [Multi-domain]  Cd Length: 266  Bit Score: 173.74  E-value: 3.75e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711 261 FRLATWNLQ--GCSVEKANNPGVREVVCMTLLensiKLLAVQELLDK----EALEKFCTELNQPilpnirkwkgpRGCWR 334
Cdd:cd10283   1 LRIASWNILnfGNSKGKEKNPAIAEIISAFDL----DLIALQEVMDNggglDALAKLVNELNKP-----------GGTWK 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711 335 SIVAEKPSSQLQKGPCYsGFLWDTAANVelrdIPGQESSPSNGHAKTVGPSPFLARFKVG--SNDLTLVNLQLTALALPG 412
Cdd:cd10283  66 YIVSDKTGGSSGDKERY-AFLYKSSKVR----KVGKAVLEKDSNTDGFARPPYAAKFKSGgtGFDFTLVNVHLKSGGSSK 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711 413 VENSSKNHSDGHRLLNFALTLqETLKGEKDVVILGDFGQGPDSSDYDILRREKFHHLIPAhtFTNISTRNPQGSKSVDNI 492
Cdd:cd10283 141 SGQGAKRVAEAQALAEYLKEL-ADEDPDDDVILLGDFNIPADEDAFKALTKAGFKSLLPD--STNLSTSFKGYANSYDNI 217

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 81883711 493 WISKSLK------KVFTGHWAVVREGLTnpwIPDNWSWGGVASEHCPVLAEL 538
Cdd:cd10283 218 FVSGNLKekfsnsGVFDFNILVDEAGEE---DLDYSKWRKQISDHDPVWVEF 266
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 127-195 1.48e-22

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 91.46  E-value: 1.48e-22
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 81883711 127 LATTVPLTPRVNINTATLAQLMSVRGLSEKMAVSIVDYRREHGPFRSVEDLVRMDGINAAFLDRIRHQV 195
Cdd:COG1555   3 ASASAAAGGKVDINTATAEELQTLPGIGPKLAQRIVEYREKNGPFKSVEDLLEVKGIGPKTLEKLKPYL 71
ComEA COG1555
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ...
 38-95 2.35e-21

DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];


Pssm-ID: 441164 [Multi-domain]  Cd Length: 72  Bit Score: 88.00  E-value: 2.35e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 81883711  38 ERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVK 95
Cdd:COG1555  11 GKVDINTATAEELQTLPGIGPKLAQRIVEYREKNGPFKSVEDLLEVKGIGPKTLEKLK 68
HHH_3 pfam12836
Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.
 37-95 5.92e-19

Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.


Pssm-ID: 463723 [Multi-domain]  Cd Length: 62  Bit Score: 80.60  E-value: 5.92e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 81883711    37 QERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVK 95
Cdd:pfam12836   1 AVGVDINTASAELLSRVPGLGPKLAKNIVEYREENGPFRSREDLLKVKGLGPKTFEQLA 59
HHH_3 pfam12836
Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.
 136-195 2.13e-18

Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.


Pssm-ID: 463723 [Multi-domain]  Cd Length: 62  Bit Score: 79.06  E-value: 2.13e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711   136 RVNINTATLAQLMSVRGLSEKMAVSIVDYRREHGPFRSVEDLVRMDGINAAFLDRIRHQV 195
Cdd:pfam12836   3 GVDINTASAELLSRVPGLGPKLAKNIVEYREENGPFRSREDLLKVKGLGPKTFEQLAGFL 62
comE TIGR01259
comEA protein; This model describes the ComEA protein in bacteria. The com E locus is ...
 40-100 2.01e-13

comEA protein; This model describes the ComEA protein in bacteria. The com E locus is obligatory for bacterial cell competence - the process of internalizing the exogenous added DNA. Lesions in the loci has been variously described for the appearance of competence-related pheonotypes and impairment of competence, suggesting their intimate functional role in bacterial transformation. [Cellular processes, DNA transformation]


Pssm-ID: 213597 [Multi-domain]  Cd Length: 120  Bit Score: 66.85  E-value: 2.01e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81883711    40 LNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVKFEICV 100
Cdd:TIGR01259  60 VNINAASLEELQALPGIGPAKAKAIIEYREENGAFKSVDDLTKVSGIGEKSLEKLKDYATV 120
comE TIGR01259
comEA protein; This model describes the ComEA protein in bacteria. The com E locus is ...
 137-195 5.49e-12

comEA protein; This model describes the ComEA protein in bacteria. The com E locus is obligatory for bacterial cell competence - the process of internalizing the exogenous added DNA. Lesions in the loci has been variously described for the appearance of competence-related pheonotypes and impairment of competence, suggesting their intimate functional role in bacterial transformation. [Cellular processes, DNA transformation]


Pssm-ID: 213597 [Multi-domain]  Cd Length: 120  Bit Score: 63.00  E-value: 5.49e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 81883711   137 VNINTATLAQLMSVRGLSEKMAVSIVDYRREHGPFRSVEDLVRMDGINAAFLDRIRHQV 195
Cdd:TIGR01259  60 VNINAASLEELQALPGIGPAKAKAIIEYREENGAFKSVDDLTKVSGIGEKSLEKLKDYA 118
TIGR00426 TIGR00426
competence protein ComEA helix-hairpin-helix repeat region; Members of the subfamily ...
 136-192 1.90e-11

competence protein ComEA helix-hairpin-helix repeat region; Members of the subfamily recognized by this model include competence protein ComEA and closely related proteins from a number of species that exhibit competence for transformation by exongenous DNA, including Streptococcus pneumoniae, Bacillus subtilis, Neisseria meningitidis, and Haemophilus influenzae. This model represents a region of two tandem copies of a helix-hairpin-helix domain (pfam00633), each about 30 residues in length. Limited sequence similarity can be found among some members of this family N-terminal to the region covered by this model. [Cellular processes, DNA transformation]


Pssm-ID: 129520 [Multi-domain]  Cd Length: 69  Bit Score: 59.56  E-value: 1.90e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 81883711   136 RVNINTATLAQLM-SVRGLSEKMAVSIVDYRREHGPFRSVEDLVRMDGINAAFLDRIR 192
Cdd:TIGR00426   7 RVNINTATAEELQrAMNGVGLKKAEAIVSYREEYGPFKTVEDLKQVPGIGNSLVEKNL 64
TIGR00426 TIGR00426
competence protein ComEA helix-hairpin-helix repeat region; Members of the subfamily ...
 39-100 2.37e-10

competence protein ComEA helix-hairpin-helix repeat region; Members of the subfamily recognized by this model include competence protein ComEA and closely related proteins from a number of species that exhibit competence for transformation by exongenous DNA, including Streptococcus pneumoniae, Bacillus subtilis, Neisseria meningitidis, and Haemophilus influenzae. This model represents a region of two tandem copies of a helix-hairpin-helix domain (pfam00633), each about 30 residues in length. Limited sequence similarity can be found among some members of this family N-terminal to the region covered by this model. [Cellular processes, DNA transformation]


Pssm-ID: 129520 [Multi-domain]  Cd Length: 69  Bit Score: 56.48  E-value: 2.37e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81883711    39 RLNINTATEEELM-TLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQVKFEICV 100
Cdd:TIGR00426   7 RVNINTATAEELQrAMNGVGLKKAEAIVSYREEYGPFKTVEDLKQVPGIGNSLVEKNLAVITL 69
EEP cd08372
Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; This large superfamily includes ...
 263-538 1.02e-07

Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; This large superfamily includes the catalytic domain (exonuclease/endonuclease/phosphatase or EEP domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds; their substrates range from nucleic acids to phospholipids and perhaps proteins.


Pssm-ID: 197306 [Multi-domain]  Cd Length: 241  Bit Score: 53.25  E-value: 1.02e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711 263 LATWNLQGCSVEKANNPGVREVVcmtllENSIKLLAVQELldkealekFCTELNQPILPNIRKwkgprgCWRSIVAEKPS 342
Cdd:cd08372   1 VASYNVNGLNAATRASGIARWVR-----ELDPDIVCLQEV--------KDSQYSAVALNQLLP------EGYHQYQSGPS 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711 343 SQLQKGPCYSGFLWDTAANVELRDIPGQESSPSNGHAKTVgpspflaRFKVGSNDLTLVNLQLtalalpgvENSSKNHSD 422
Cdd:cd08372  62 RKEGYEGVAILSKTPKFKIVEKHQYKFGEGDSGERRAVVV-------KFDVHDKELCVVNAHL--------QAGGTRADV 126

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711 423 GhrlLNFALTLQETLKGE-----KDVVILGDFGQGPDSSDYDILRRE---------KFHHLIPAHTFTNISTRNPQGSKs 488
Cdd:cd08372 127 R---DAQLKEVLEFLKRLrqpnsAPVVICGDFNVRPSEVDSENPSSMlrlfvalnlVDSFETLPHAYTFDTYMHNVKSR- 202

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 81883711 489 VDNIWISKSLKkvftghwAVVREGltnpWIPDNWSWGGVASEHCPVLAEL 538
Cdd:cd08372 203 LDYIFVSKSLL-------PSVKSS----KILSDAARARIPSDHYPIEVTL 241
Tex COG2183
Transcriptional accessory protein Tex/SPT6 [Transcription];
137-177 2.99e-07

Transcriptional accessory protein Tex/SPT6 [Transcription];


Pssm-ID: 441786 [Multi-domain]  Cd Length: 719  Bit Score: 53.49  E-value: 2.99e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 81883711 137 VNINTATlAQLMS-VRGLSEKMAVSIVDYRREHGPFRSVEDL 177
Cdd:COG2183 487 VDLNTAS-APLLSyVSGLNPTLAKNIVAYRDENGAFKSRKEL 527
HHH pfam00633
Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated ...
 41-67 4.13e-06

Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.


Pssm-ID: 425789 [Multi-domain]  Cd Length: 30  Bit Score: 43.56  E-value: 4.13e-06
                          10        20
                  ....*....|....*....|....*..
gi 81883711    41 NINTATEEELMTLPGVTRAVARSIVEY 67
Cdd:pfam00633   4 GLIPASVEELLALPGVGPKTAEAILSY 30
COG2374 COG2374
Predicted extracellular nuclease [General function prediction only];
426-542 5.32e-05

Predicted extracellular nuclease [General function prediction only];


Pssm-ID: 441941 [Multi-domain]  Cd Length: 362  Bit Score: 45.78  E-value: 5.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711 426 LLNFALTLQeTLKGEKDVVILGDFGQGPDSSDYDILRREK-FHHLIPAHTFTNISTRNPQGSKSV-DNIWISKSLKKVFT 503
Cdd:COG2374 240 LRAFVDSLL-AADPDAPVIVLGDFNDYPFEDPLRALLGAGgLTNLAEKLPAAERYSYVYDGNSGLlDHILVSPALAARVT 318

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 81883711 504 G--HW----AVVREGLTNPWIPDNWSWGGvASEHCPVLAELYMEK 542
Cdd:COG2374 319 GadIWhinaDIYNDDFKPDFRTYADDPGR-ASDHDPVVVGLRLPP 362
PulK COG3156
Type II secretory pathway, component PulK [Intracellular trafficking, secretion, and vesicular ...
 39-93 5.39e-05

Type II secretory pathway, component PulK [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442390 [Multi-domain]  Cd Length: 307  Bit Score: 45.38  E-value: 5.39e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 81883711  39 RLNINTATEEELMTL-PGVTRAVARSIVEYREyIGGFKKVEDLALVSGVGATKLEQ 93
Cdd:COG3156 212 KINVNTAPPEVLAALlGGLSLDDAQALLAARP-EKGFADVADFLALLGLAGLDLLK 266
DnaE COG0587
DNA polymerase III, alpha subunit [Replication, recombination and repair];
147-179 1.61e-04

DNA polymerase III, alpha subunit [Replication, recombination and repair];


Pssm-ID: 440352 [Multi-domain]  Cd Length: 1050  Bit Score: 44.67  E-value: 1.61e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 81883711  147 LMSVRGLSEKMAVSIVDYRREHGPFRSVEDLVR 179
Cdd:COG0587  817 LGAIKGVGEAAAEAIVAAREENGPFTSLFDFCR 849
T2SS_GspK NF037980
type II secretion system minor pseudopilin GspK;
33-95 1.77e-04

type II secretion system minor pseudopilin GspK;


Pssm-ID: 468299 [Multi-domain]  Cd Length: 311  Bit Score: 43.82  E-value: 1.77e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81883711   33 ILVNQERLNINTATEEELMTL-PGVTRAVARSIVEYREYiGGFKKVEDLALVSGVGATKLEQVK 95
Cdd:NF037980 206 LPTTTLAINVNTAPAEVLAALaALLSLSQARALLAARPA-AGFRSVGDFLAQLALAGLALDASD 268
EEP-1 cd09083
Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; This family of ...
 443-538 2.34e-04

Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; This family of uncharacterized proteins belongs to a superfamily that includes the catalytic domain (exonuclease/endonuclease/phosphatase, EEP, domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds. Their substrates range from nucleic acids to phospholipids and perhaps, proteins.


Pssm-ID: 197317 [Multi-domain]  Cd Length: 252  Bit Score: 42.97  E-value: 2.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711 443 VVILGDFGQGPDSSDYDILRREKF---------HHLIPAHTFTNIsTRNPQGSKsVDNIWISKSLKKVftgHWAVVRegl 513
Cdd:cd09083 163 VILTGDFNAEPDSEPYKTLTSGGLkdardtaatTDGGPEGTFHGF-KGPPGGSR-IDYIFVSPGVKVL---SYEILT--- 234

                        90       100
                ....*....|....*....|....*
gi 81883711 514 tnpwipDNWSwGGVASEHCPVLAEL 538
Cdd:cd09083 235 ------DRYD-GRYPSDHFPVVADL 252
Tex COG2183
Transcriptional accessory protein Tex/SPT6 [Transcription];
35-93 2.94e-04

Transcriptional accessory protein Tex/SPT6 [Transcription];


Pssm-ID: 441786 [Multi-domain]  Cd Length: 719  Bit Score: 43.86  E-value: 2.94e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 81883711  35 VNQERLNINTATEEELMTLPGVTRAVARSIVEYREYIGGFKKVEDLALVSGVGATKLEQ 93
Cdd:COG2183 482 VNAVGVDLNTASAPLLSYVSGLNPTLAKNIVAYRDENGAFKSRKELLKVPRLGPKAFEQ 540
PulK COG3156
Type II secretory pathway, component PulK [Intracellular trafficking, secretion, and vesicular ...
 110-190 4.33e-04

Type II secretory pathway, component PulK [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442390 [Multi-domain]  Cd Length: 307  Bit Score: 42.68  E-value: 4.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711 110 SPSSLR------RDLLAEQQPHhlATTVPLTPRVNINTATLAQLMSV-RGLSEKMAVSIVDYRREhGPFRSVEDLVRMDG 182
Cdd:COG3156 182 SVSELRlvkgmtPELYARLAPY--VTALPGDTKINVNTAPPEVLAALlGGLSLDDAQALLAARPE-KGFADVADFLALLG 258


                ....*...
gi 81883711 183 INAAFLDR 190
Cdd:COG3156 259 LAGLDLLK 266
T2SS_GspK NF037980
type II secretion system minor pseudopilin GspK;
109-195 5.15e-04

type II secretion system minor pseudopilin GspK;


Pssm-ID: 468299 [Multi-domain]  Cd Length: 311  Bit Score: 42.28  E-value: 5.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711  109 HSPSSLRR------DLLAEQQPHhlATTVP-LTPRVNINTATLAQLMSVR-GLSEKMAVSIVDyRREHGPFRSVEDL--- 177
Cdd:NF037980 180 ADVSELRLvpgvtpALYARLRPY--VCALPtTTLAINVNTAPAEVLAALAaLLSLSQARALLA-ARPAAGFRSVGDFlaq 256

                         90
                 ....*....|....*...
gi 81883711  178 VRMDGINAAFLDRIRHQV 195
Cdd:NF037980 257 LALAGLALDASDKEQLGV 274
T2SSK pfam03934
Type II secretion system (T2SS), protein K; Members of this family are involved in the Type II ...
 39-102 5.68e-04

Type II secretion system (T2SS), protein K; Members of this family are involved in the Type II protein secretion system. The T2SK family includes proteins such as ExeK, PulK, OutX and XcpX.


Pssm-ID: 427597 [Multi-domain]  Cd Length: 283  Bit Score: 41.93  E-value: 5.68e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81883711    39 RLNINTATEEELMTL-PGVTRAVARSIVEYREyIGGFKKVED---LALVSGVGATKLEQVKFEICVSS 102
Cdd:pfam03934 185 PINVNTAPAEVLAALfDGLSLDQAQALLAQRP-ADGFESVDDflaQPALGGGIAPSTAQLKTLLTVKS 251
dnaE2 PRK05672
error-prone DNA polymerase; Validated
 133-189 7.21e-04

error-prone DNA polymerase; Validated


Pssm-ID: 235553 [Multi-domain]  Cd Length: 1046  Bit Score: 42.54  E-value: 7.21e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 81883711   133 LTPRVNINTATLAQLMSVRGLSEKMAVSIVDyRREHGPFRSVEDLVRMDGINAAFLD 189
Cdd:PRK05672  804 LEPLPDGGPAVRLGLRLVRGLGEEAAERIVA-ARARGPFTSVEDLARRAGLDRRQLE 859
HHH_6 pfam14579
Helix-hairpin-helix motif; The HHH domain is a short DNA-binding domain.
 147-179 1.39e-03

Helix-hairpin-helix motif; The HHH domain is a short DNA-binding domain.


Pssm-ID: 434050 [Multi-domain]  Cd Length: 88  Bit Score: 37.84  E-value: 1.39e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 81883711   147 LMSVRGLSEKMAVSIVDyRREHGPFRSVEDLVR 179
Cdd:pfam14579  27 LGAIKGLGEAAAERIVE-ERENGPFKSLEDFAR 58
HHH_5 pfam14520
Helix-hairpin-helix domain;
47-98 3.01e-03

Helix-hairpin-helix domain;


Pssm-ID: 434010 [Multi-domain]  Cd Length: 57  Bit Score: 35.93  E-value: 3.01e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883711    47 EEELMTLPGVTRAVARSIVEyreyiGGFKKVEDLA--------LVSGVGATKLEQVKFEI 98
Cdd:pfam14520   1 FEELLSISGIGPKTALALLS-----AGIGTVEDLAeadvdelaEIPGIGEKTAQRIILEL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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