NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|254801705|sp|Q5UYR8|]
View 

RecName: Full=GTP-dependent dephospho-CoA kinase; AltName: Full=Dephospho-coenzyme A kinase; Short=DPCK

Protein Classification

GTP-dependent dephospho-CoA kinase family protein( domain architecture ID 10004882)

GTP-dependent dephospho-CoA kinase (DPCK) family protein is a DUF359 domain-containing protein similar to DPCK that catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DPCK COG1909
Archaeal dephospho-CoA kinase [Coenzyme transport and metabolism];
5-171 9.86e-74

Archaeal dephospho-CoA kinase [Coenzyme transport and metabolism];


:

Pssm-ID: 441513  Cd Length: 169  Bit Score: 218.94  E-value: 9.86e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254801705   5 VLELPSDLRHELKEPLGRIYTDTAALLADAGD------PIIAVGDMVTYHLIEAGRTPDLALVDERTERSAVDADvaaaI 78
Cdd:COG1909    1 MLRLPEELREELKEPFGPLYTDAEDLLEDVREelkkakPLITVGDVVTYNLLEAGIVPDLAIVDGKTKREPVDEE----V 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254801705  79 DGFDRTLSVDNPAATLTADLLAALRDGLDSDETTLLDVDGEEDLATLPAVLAAPAGASVVYGQPDEGMVLADCDDTARDR 158
Cdd:COG1909   77 RTGYRVLEVKNPPGTITEELIEAIKEALESGEPTLILVDGEEDLAVLPAILLAPEGSVVVYGQPGEGMVLVKVTEEAKER 156

                        170
                 ....*....|...
gi 254801705 159 VRSLLERMDGDAE 171
Cdd:COG1909  157 ARELLDKFEGDEE 169
 
Name Accession Description Interval E-value
DPCK COG1909
Archaeal dephospho-CoA kinase [Coenzyme transport and metabolism];
5-171 9.86e-74

Archaeal dephospho-CoA kinase [Coenzyme transport and metabolism];


Pssm-ID: 441513  Cd Length: 169  Bit Score: 218.94  E-value: 9.86e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254801705   5 VLELPSDLRHELKEPLGRIYTDTAALLADAGD------PIIAVGDMVTYHLIEAGRTPDLALVDERTERSAVDADvaaaI 78
Cdd:COG1909    1 MLRLPEELREELKEPFGPLYTDAEDLLEDVREelkkakPLITVGDVVTYNLLEAGIVPDLAIVDGKTKREPVDEE----V 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254801705  79 DGFDRTLSVDNPAATLTADLLAALRDGLDSDETTLLDVDGEEDLATLPAVLAAPAGASVVYGQPDEGMVLADCDDTARDR 158
Cdd:COG1909   77 RTGYRVLEVKNPPGTITEELIEAIKEALESGEPTLILVDGEEDLAVLPAILLAPEGSVVVYGQPGEGMVLVKVTEEAKER 156

                        170
                 ....*....|...
gi 254801705 159 VRSLLERMDGDAE 171
Cdd:COG1909  157 ARELLDKFEGDEE 169
DUF359 pfam04019
Protein of unknown function (DUF359); This family of archaebacterial proteins are about 170 ...
 45-167 3.27e-53

Protein of unknown function (DUF359); This family of archaebacterial proteins are about 170 amino acids in length. They have no known function. The most conserved portion of the protein contains the sequence GEEDL that may be important for its function.


Pssm-ID: 427654  Cd Length: 122  Bit Score: 165.41  E-value: 3.27e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254801705   45 VTYHLIEAGRTPDLALVDERTERSAVDADVAAaIDGFDRTLSVDNPAATLTADLLAALRDGLDSDETTLLDVDGEEDLAT 124
Cdd:pfam04019   1 VTYNLLKAGIIPDLAIVDGKTKREDTITIVKI-LPGFYRVIEVKNPPGTITEELIEAIREALESGEPTLILVDGEEDLAV 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 254801705  125 LPAVLAAPAGASVVYGQPDEGMVLADCDDTARDRVRSLLERMD 167
Cdd:pfam04019  80 LPAILYAPDGSVVVYGQPGEGMVLVKVTEEAKEEARELLEKFE 122
PRK01160 PRK01160
hypothetical protein; Provisional
 2-169 1.00e-39

hypothetical protein; Provisional


Pssm-ID: 234911  Cd Length: 178  Bit Score: 132.96  E-value: 1.00e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254801705   2 SDVVLELPSDLRHELKEPLGRI--------YTDTAALLAdaGDPIIAVGDMVTYHLIEAGRTPDLALVDERTERSAVDAD 73
Cdd:PRK01160   1 MDFYFKLTPELRQELKKPLGELvrgdipepYLKIKEELE--KHPLITVGDVVTENLLRVGLKPFLAIYDLKTKRREYKPS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254801705  74 VAAAIDGFdrtLSVDNPAATLTADLLAALRDG---LDSDETTLLDVDGEEDLATLPAVLAAPAGASVVYGQPDEGMVLAD 150
Cdd:PRK01160  79 IFEHEEVS---ITVRNPPGTITLALLRAIKKAfslIERGKKVRIEVNGEEDLAVIPAVLYAPLGTVVAYGQPDEGMVLIK 155

                        170       180
                 ....*....|....*....|...
gi 254801705 151 CDDTARDRVRSLLERM----DGD 169
Cdd:PRK01160 156 VTPECKRRCAEILRKMevvrDGD 178
 
Name Accession Description Interval E-value
DPCK COG1909
Archaeal dephospho-CoA kinase [Coenzyme transport and metabolism];
5-171 9.86e-74

Archaeal dephospho-CoA kinase [Coenzyme transport and metabolism];


Pssm-ID: 441513  Cd Length: 169  Bit Score: 218.94  E-value: 9.86e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254801705   5 VLELPSDLRHELKEPLGRIYTDTAALLADAGD------PIIAVGDMVTYHLIEAGRTPDLALVDERTERSAVDADvaaaI 78
Cdd:COG1909    1 MLRLPEELREELKEPFGPLYTDAEDLLEDVREelkkakPLITVGDVVTYNLLEAGIVPDLAIVDGKTKREPVDEE----V 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254801705  79 DGFDRTLSVDNPAATLTADLLAALRDGLDSDETTLLDVDGEEDLATLPAVLAAPAGASVVYGQPDEGMVLADCDDTARDR 158
Cdd:COG1909   77 RTGYRVLEVKNPPGTITEELIEAIKEALESGEPTLILVDGEEDLAVLPAILLAPEGSVVVYGQPGEGMVLVKVTEEAKER 156

                        170
                 ....*....|...
gi 254801705 159 VRSLLERMDGDAE 171
Cdd:COG1909  157 ARELLDKFEGDEE 169
DUF359 pfam04019
Protein of unknown function (DUF359); This family of archaebacterial proteins are about 170 ...
 45-167 3.27e-53

Protein of unknown function (DUF359); This family of archaebacterial proteins are about 170 amino acids in length. They have no known function. The most conserved portion of the protein contains the sequence GEEDL that may be important for its function.


Pssm-ID: 427654  Cd Length: 122  Bit Score: 165.41  E-value: 3.27e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254801705   45 VTYHLIEAGRTPDLALVDERTERSAVDADVAAaIDGFDRTLSVDNPAATLTADLLAALRDGLDSDETTLLDVDGEEDLAT 124
Cdd:pfam04019   1 VTYNLLKAGIIPDLAIVDGKTKREDTITIVKI-LPGFYRVIEVKNPPGTITEELIEAIREALESGEPTLILVDGEEDLAV 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 254801705  125 LPAVLAAPAGASVVYGQPDEGMVLADCDDTARDRVRSLLERMD 167
Cdd:pfam04019  80 LPAILYAPDGSVVVYGQPGEGMVLVKVTEEAKEEARELLEKFE 122
PRK01160 PRK01160
hypothetical protein; Provisional
 2-169 1.00e-39

hypothetical protein; Provisional


Pssm-ID: 234911  Cd Length: 178  Bit Score: 132.96  E-value: 1.00e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254801705   2 SDVVLELPSDLRHELKEPLGRI--------YTDTAALLAdaGDPIIAVGDMVTYHLIEAGRTPDLALVDERTERSAVDAD 73
Cdd:PRK01160   1 MDFYFKLTPELRQELKKPLGELvrgdipepYLKIKEELE--KHPLITVGDVVTENLLRVGLKPFLAIYDLKTKRREYKPS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254801705  74 VAAAIDGFdrtLSVDNPAATLTADLLAALRDG---LDSDETTLLDVDGEEDLATLPAVLAAPAGASVVYGQPDEGMVLAD 150
Cdd:PRK01160  79 IFEHEEVS---ITVRNPPGTITLALLRAIKKAfslIERGKKVRIEVNGEEDLAVIPAVLYAPLGTVVAYGQPDEGMVLIK 155

                        170       180
                 ....*....|....*....|...
gi 254801705 151 CDDTARDRVRSLLERM----DGD 169
Cdd:PRK01160 156 VTPECKRRCAEILRKMevvrDGD 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH