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Conserved domains on  [gi|81883610|sp|Q5U4E0|]
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RecName: Full=LHFPL tetraspan subfamily member 4 protein; AltName: Full=GABAA receptor regulatory Lhfpl4; AltName: Full=Lipoma HMGIC fusion partner-like 4 protein

Protein Classification

LHFPL tetraspan protein( domain architecture ID 10563002)

LHFPL (lipoma HMGIC fusion partner-like) tetraspan protein similar to human LHFPL5 that may be a component of hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
L_HMGIC_fpl pfam10242
Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series ...
 22-200 4.65e-86

Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series of genes referred to as Lipoma HMGIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumour cell lines.


:

Pssm-ID: 463019  Cd Length: 176  Bit Score: 253.41  E-value: 4.65e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883610    22 IGVLWAIFTICFAIINVVVFIQPYWVGDSVSTPKPGYFGLFHYCVGSGlaGRELTCRGSFTDFSTIPSSAFKAAAFFVLL 101
Cdd:pfam10242   1 VGVLWALLSICFAVLSVVAFVQPYWLGGSVSSPKAGSFGLYSRCVGPD--QMVLTCGRYALDFLAIPSSAWQAAMFFVGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883610   102 SMVLiLGCITCFALFFFCNTATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCGAKTGKYSLGDCSVRWAYILAI 181
Cdd:pfam10242  79 GIFL-LLSIACLSLFTFCRSKSVFNICGWLQLIAGLCLMLGCMLYPDGWDSPEVRRYCGPEAGKFQLGLCSIGWAYYLAI 157

                         170
                  ....*....|....*....
gi 81883610   182 IGILNALILSFLAFVLGNR 200
Cdd:pfam10242 158 IGIADALLLTFLAFVLSLR 176
 
Name Accession Description Interval E-value
L_HMGIC_fpl pfam10242
Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series ...
 22-200 4.65e-86

Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series of genes referred to as Lipoma HMGIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumour cell lines.


Pssm-ID: 463019  Cd Length: 176  Bit Score: 253.41  E-value: 4.65e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883610    22 IGVLWAIFTICFAIINVVVFIQPYWVGDSVSTPKPGYFGLFHYCVGSGlaGRELTCRGSFTDFSTIPSSAFKAAAFFVLL 101
Cdd:pfam10242   1 VGVLWALLSICFAVLSVVAFVQPYWLGGSVSSPKAGSFGLYSRCVGPD--QMVLTCGRYALDFLAIPSSAWQAAMFFVGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883610   102 SMVLiLGCITCFALFFFCNTATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCGAKTGKYSLGDCSVRWAYILAI 181
Cdd:pfam10242  79 GIFL-LLSIACLSLFTFCRSKSVFNICGWLQLIAGLCLMLGCMLYPDGWDSPEVRRYCGPEAGKFQLGLCSIGWAYYLAI 157

                         170
                  ....*....|....*....
gi 81883610   182 IGILNALILSFLAFVLGNR 200
Cdd:pfam10242 158 IGIADALLLTFLAFVLSLR 176
 
Name Accession Description Interval E-value
L_HMGIC_fpl pfam10242
Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series ...
 22-200 4.65e-86

Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series of genes referred to as Lipoma HMGIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumour cell lines.


Pssm-ID: 463019  Cd Length: 176  Bit Score: 253.41  E-value: 4.65e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883610    22 IGVLWAIFTICFAIINVVVFIQPYWVGDSVSTPKPGYFGLFHYCVGSGlaGRELTCRGSFTDFSTIPSSAFKAAAFFVLL 101
Cdd:pfam10242   1 VGVLWALLSICFAVLSVVAFVQPYWLGGSVSSPKAGSFGLYSRCVGPD--QMVLTCGRYALDFLAIPSSAWQAAMFFVGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81883610   102 SMVLiLGCITCFALFFFCNTATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCGAKTGKYSLGDCSVRWAYILAI 181
Cdd:pfam10242  79 GIFL-LLSIACLSLFTFCRSKSVFNICGWLQLIAGLCLMLGCMLYPDGWDSPEVRRYCGPEAGKFQLGLCSIGWAYYLAI 157

                         170
                  ....*....|....*....
gi 81883610   182 IGILNALILSFLAFVLGNR 200
Cdd:pfam10242 158 IGIADALLLTFLAFVLSLR 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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