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Conserved domains on  [gi|81871948|sp|Q5SZV5|]
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RecName: Full=Dyslexia-associated protein KIAA0319 homolog; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
myxo_dep_M36 super family cl45606
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 440-825 3.63e-35

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


The actual alignment was detected with superfamily member NF038112:

Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 145.96  E-value: 3.63e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   440 NQPPVAVVSPQTQELsvPLTSALIDGSQSTD-DTEIVSYHWEEVDGP-------------FLGEEFPADTpilrlsnlvp 505
Cdd:NF038112 1185 NRRPVANAGPDQTVL--ERTTVTLNGSGSFDpDGDPLTYAWTQVSGPavtltgadtatpsFTAPEVTADT---------- 1252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   506 gNYTFRLTITDSDGATNSTTASLVIRDaVDYPPVANAGPNQTITlPQNTIILNGNQSSDDHQIVLYEWF--AGPggeskE 583
Cdd:NF038112 1253 -VLTFQLVVSDGTKTSAPDTVTVLVRN-VNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWTqtSGP-----A 1324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   584 MVMQGAQT-------PYLHLSElqegEYTFQLMVTDSSgQQSTALVAVTVQaENNQAPVAVAGPDKElVFPVQSATLDGS 656
Cdd:NF038112 1325 VTLTGATTatatftaPEVTADT----QLTFTLTVSDGT-ASATDTVTVTVR-NVNRAPVANAGADQT-VDERSTVTLSGS 1397

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   657 RSSDDHGIVCYHWEHIRGPsAVEMENVDKAIATVTGLQVG---IYHFRLTVRDQQGLSSTSTLTVAVKKENNSPpRAQAG 733
Cdd:NF038112 1398 ATDPDGDALTYAWTQTAGP-TVTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRNVNRAP-VAHAG 1475

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   734 GRhVLILPNNSITLDGSRSTDDRGIVSYLWIRDGQSP-------AAGDVIGGSDHRAALQLTnlvegvytFHLLVTDSQG 806
Cdd:NF038112 1476 ES-ITVDEGSTVTLDASATDPDGDTLTYAWTQVAGPSvtltgadSAKLTFTAPEVSADTTLT--------FSLTVTDGSG 1546

                         410
                  ....*....|....*....
gi 81871948   807 ASDSDAATVEVLPDPKKDG 825
Cdd:NF038112 1547 SSGPVVVTVTVKNVNRAPD 1565
MANEC super family cl06508
MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the ...
 23-102 1.15e-12

MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.


The actual alignment was detected with superfamily member smart00765:

Pssm-ID: 471454  Cd Length: 93  Bit Score: 64.78  E-value: 1.15e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948      23 QQCSEG-RTYSDAIISPNPETIRIMRV----SQTFSVGDCTAACCDLLTCDLAWWF------EGSCYLVKCMRS--ENCE 89
Cdd:smart00765    4 EDCLGRfRVLENAIIRTEESLSAGARFlkspIAVNTWEDCVRACCSTPNCNLAVFElrredaEGNCYLFNCTYPgkEVCK 83

                            90
                    ....*....|...
gi 81871948      90 prtTGPIRSYLTF 102
Cdd:smart00765   84 ---FKPHEGYTSY 93
REJ super family cl28747
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 284-571 2.90e-03

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


The actual alignment was detected with superfamily member pfam02010:

Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 41.33  E-value: 2.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    284 NPSPASLESSPATTEKNSNFTVTPRSRKHSTPTFPTS-TVLTGLTPPPwplsptasrTVKALAVSAgDNLVLTLPDREAe 362
Cdd:pfam02010  156 QSTSSSLTIPASTLQANVTYTFKLTVSKGSRNSASTTqTILVVDGNPP---------IIILSCISN-CNRKNNPVDRLV- 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    363 LKASVEPAPPADT-TYSYEWSLMSHPVDFQGKIKQENKPTLHLSQ---------LSVGL-YAFRVAVSSENAFGEGYVNV 431
Cdd:pfam02010  225 LLASTCLNCSSDLsDVTYRWLSLGSENTSLVLDQLNSQTSTGRSGpylvikagvLQSGVsYRFTLIVTVYPGLVSGLASI 304

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    432 TVmpaaRVNQPP------------VAVVSPQTQ------ELSVPLTSALIDGSQSTDDTE--IVSYHWEEVDGPFLgeeF 491
Cdd:pfam02010  305 SF----ITNAPPtggtcsvtptegTALETKFTVtcqgwtDDDLPLTYQFGDISFREASEEwfLLYEGSSQISISTF---L 377

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    492 PadtpilrlSNLVPGNYTFRL--TITDSDGATNSTTASLVIRdavdyPPVANAGPNQTITLPQNTiiLNGNQSSDDHQIV 569
Cdd:pfam02010  378 P--------PGLPANDYQVTVvvVVYDSLGAATSVSLTITVT-----PPSSSDELLYFLLGTTSD--LSALLQSGDPQQA 442


                   ..
gi 81871948    570 LY 571
Cdd:pfam02010  443 AQ 444
 
Name Accession Description Interval E-value
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 440-825 3.63e-35

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 145.96  E-value: 3.63e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   440 NQPPVAVVSPQTQELsvPLTSALIDGSQSTD-DTEIVSYHWEEVDGP-------------FLGEEFPADTpilrlsnlvp 505
Cdd:NF038112 1185 NRRPVANAGPDQTVL--ERTTVTLNGSGSFDpDGDPLTYAWTQVSGPavtltgadtatpsFTAPEVTADT---------- 1252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   506 gNYTFRLTITDSDGATNSTTASLVIRDaVDYPPVANAGPNQTITlPQNTIILNGNQSSDDHQIVLYEWF--AGPggeskE 583
Cdd:NF038112 1253 -VLTFQLVVSDGTKTSAPDTVTVLVRN-VNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWTqtSGP-----A 1324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   584 MVMQGAQT-------PYLHLSElqegEYTFQLMVTDSSgQQSTALVAVTVQaENNQAPVAVAGPDKElVFPVQSATLDGS 656
Cdd:NF038112 1325 VTLTGATTatatftaPEVTADT----QLTFTLTVSDGT-ASATDTVTVTVR-NVNRAPVANAGADQT-VDERSTVTLSGS 1397

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   657 RSSDDHGIVCYHWEHIRGPsAVEMENVDKAIATVTGLQVG---IYHFRLTVRDQQGLSSTSTLTVAVKKENNSPpRAQAG 733
Cdd:NF038112 1398 ATDPDGDALTYAWTQTAGP-TVTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRNVNRAP-VAHAG 1475

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   734 GRhVLILPNNSITLDGSRSTDDRGIVSYLWIRDGQSP-------AAGDVIGGSDHRAALQLTnlvegvytFHLLVTDSQG 806
Cdd:NF038112 1476 ES-ITVDEGSTVTLDASATDPDGDTLTYAWTQVAGPSvtltgadSAKLTFTAPEVSADTTLT--------FSLTVTDGSG 1546

                         410
                  ....*....|....*....
gi 81871948   807 ASDSDAATVEVLPDPKKDG 825
Cdd:NF038112 1547 SSGPVVVTVTVKNVNRAPD 1565
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 429-741 2.71e-32

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 136.71  E-value: 2.71e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   429 VNVTVmpaARVNQPPVAVVS-PQTQELSVPLTsalIDGSQSTDDTEIVSYHWEEVDGP-------------FLGEEFPAD 494
Cdd:NF038112 1272 VTVLV---RNVNRAPVAVAGaPATVDERSTVT---LDGSGTDADGDALTYAWTQTSGPavtltgattatatFTAPEVTAD 1345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   495 TPIlrlsnlvpgnyTFRLTITDSdGATNSTTASLVIRDaVDYPPVANAGPNQTITlPQNTIILNGNQSSDDHQIVLYEWF 574
Cdd:NF038112 1346 TQL-----------TFTLTVSDG-TASATDTVTVTVRN-VNRAPVANAGADQTVD-ERSTVTLSGSATDPDGDALTYAWT 1411

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   575 --AGPGGEskemvMQGAQTPYLHL---SELQEGEYTFQLMVTdsSGQQSTALVAVTVQAEN-NQAPVAVAGPDKElVFPV 648
Cdd:NF038112 1412 qtAGPTVT-----LTGADTATASFtapEVAADTELTFQLTVS--ADGQASADVTVTVTVRNvNRAPVAHAGESIT-VDEG 1483

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   649 QSATLDGSRSSDDHGIVCYHWEHIRGPSaVEMENVDKAIATVTGLQVG---IYHFRLTVRDQQGLSSTSTLTVAVKKENN 725
Cdd:NF038112 1484 STVTLDASATDPDGDTLTYAWTQVAGPS-VTLTGADSAKLTFTAPEVSadtTLTFSLTVTDGSGSSGPVVVTVTVKNVNR 1562

                         330
                  ....*....|....*....
gi 81871948   726 SPPR---AQAGGRHVLILP 741
Cdd:NF038112 1563 APDGggcSSTGGSPGGMLP 1581
MANEC smart00765
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ...
 23-102 1.15e-12

The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.


Pssm-ID: 129004  Cd Length: 93  Bit Score: 64.78  E-value: 1.15e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948      23 QQCSEG-RTYSDAIISPNPETIRIMRV----SQTFSVGDCTAACCDLLTCDLAWWF------EGSCYLVKCMRS--ENCE 89
Cdd:smart00765    4 EDCLGRfRVLENAIIRTEESLSAGARFlkspIAVNTWEDCVRACCSTPNCNLAVFElrredaEGNCYLFNCTYPgkEVCK 83

                            90
                    ....*....|...
gi 81871948      90 prtTGPIRSYLTF 102
Cdd:smart00765   84 ---FKPHEGYTSY 93
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 379-618 4.10e-08

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 57.13  E-value: 4.10e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    379 YEWSLMSHPVDFqGKIKQENKPTLHLSQ-------LSVGLYAFRVAVSSE---NAFGEGYVNVTVMPAarvnqPPVAVVS 448
Cdd:pfam02010   16 YLWSVFTVSSNL-NLQTISSPKDLVLPQltipsgtLPYGTYVFTLTVSLSstpSLAGTDIITVTVQPS-----PLVAVID 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    449 PQTqELSVPLTSALI-DGSQSTD------DTEIVSYHWEEVDGPFL--------GEEFPADTPILRL-----------SN 502
Cdd:pfam02010   90 GGS-SRVVGYNQDLTlDGSESYDpdvdpgSSSGLTYLWSCRRSSSGdnpllnndPVCFSDQNEGTLLqstsssltipaST 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    503 LVPG-NYTFRLTITDSDGATNSTTASLVIRDavDYPP------VANAgpNQTITLPQNTIILNG--NQSSDDHQIVLYEW 573
Cdd:pfam02010  169 LQANvTYTFKLTVSKGSRNSASTTQTILVVD--GNPPiiilscISNC--NRKNNPVDRLVLLAStcLNCSSDLSDVTYRW 244

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 81871948    574 FAGPGGESKEM-------VMQGAQTPYLHLSE--LQEG-EYTFQLMVTDSSGQQS 618
Cdd:pfam02010  245 LSLGSENTSLVldqlnsqTSTGRSGPYLVIKAgvLQSGvSYRFTLIVTVYPGLVS 299
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 444-530 1.34e-07

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 49.76  E-value: 1.34e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948     444 VAVVSPQTQELSVPLTSALIDgsQSTDDTEIVSYHWEEVDGPFLGEefpadtPILRLSNLVPGNYTFRLTITDSDGaTNS 523
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTA--TSSDDGSIVSYTWDFGDGTSSTG------PTVTHTYTKPGTYTVTLTVTNAVG-SAS 71


                    ....*..
gi 81871948     524 TTASLVI 530
Cdd:smart00089   72 ATVTVVV 78
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 635-720 9.95e-07

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 47.49  E-value: 9.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948  635 VAVAGPDKELVFPVQSATLDGSrSSDDHGIVCYHWehIRGPSAVEMENVdkAIATVTGLQVGIYHFRLTVRDQQGLSSTS 714
Cdd:cd00146    1 PTASVSAPPVAELGASVTFSAS-DSSGGSIVSYKW--DFGDGEVSSSGE--PTVTHTYTKPGTYTVTLTVTNAVGSSSTK 75


                 ....*.
gi 81871948  715 TLTVAV 720
Cdd:cd00146   76 TTTVVV 81
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 284-571 2.90e-03

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 41.33  E-value: 2.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    284 NPSPASLESSPATTEKNSNFTVTPRSRKHSTPTFPTS-TVLTGLTPPPwplsptasrTVKALAVSAgDNLVLTLPDREAe 362
Cdd:pfam02010  156 QSTSSSLTIPASTLQANVTYTFKLTVSKGSRNSASTTqTILVVDGNPP---------IIILSCISN-CNRKNNPVDRLV- 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    363 LKASVEPAPPADT-TYSYEWSLMSHPVDFQGKIKQENKPTLHLSQ---------LSVGL-YAFRVAVSSENAFGEGYVNV 431
Cdd:pfam02010  225 LLASTCLNCSSDLsDVTYRWLSLGSENTSLVLDQLNSQTSTGRSGpylvikagvLQSGVsYRFTLIVTVYPGLVSGLASI 304

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    432 TVmpaaRVNQPP------------VAVVSPQTQ------ELSVPLTSALIDGSQSTDDTE--IVSYHWEEVDGPFLgeeF 491
Cdd:pfam02010  305 SF----ITNAPPtggtcsvtptegTALETKFTVtcqgwtDDDLPLTYQFGDISFREASEEwfLLYEGSSQISISTF---L 377

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    492 PadtpilrlSNLVPGNYTFRL--TITDSDGATNSTTASLVIRdavdyPPVANAGPNQTITLPQNTiiLNGNQSSDDHQIV 569
Cdd:pfam02010  378 P--------PGLPANDYQVTVvvVVYDSLGAATSVSLTITVT-----PPSSSDELLYFLLGTTSD--LSALLQSGDPQQA 442


                   ..
gi 81871948    570 LY 571
Cdd:pfam02010  443 AQ 444
 
Name Accession Description Interval E-value
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 440-825 3.63e-35

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 145.96  E-value: 3.63e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   440 NQPPVAVVSPQTQELsvPLTSALIDGSQSTD-DTEIVSYHWEEVDGP-------------FLGEEFPADTpilrlsnlvp 505
Cdd:NF038112 1185 NRRPVANAGPDQTVL--ERTTVTLNGSGSFDpDGDPLTYAWTQVSGPavtltgadtatpsFTAPEVTADT---------- 1252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   506 gNYTFRLTITDSDGATNSTTASLVIRDaVDYPPVANAGPNQTITlPQNTIILNGNQSSDDHQIVLYEWF--AGPggeskE 583
Cdd:NF038112 1253 -VLTFQLVVSDGTKTSAPDTVTVLVRN-VNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWTqtSGP-----A 1324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   584 MVMQGAQT-------PYLHLSElqegEYTFQLMVTDSSgQQSTALVAVTVQaENNQAPVAVAGPDKElVFPVQSATLDGS 656
Cdd:NF038112 1325 VTLTGATTatatftaPEVTADT----QLTFTLTVSDGT-ASATDTVTVTVR-NVNRAPVANAGADQT-VDERSTVTLSGS 1397

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   657 RSSDDHGIVCYHWEHIRGPsAVEMENVDKAIATVTGLQVG---IYHFRLTVRDQQGLSSTSTLTVAVKKENNSPpRAQAG 733
Cdd:NF038112 1398 ATDPDGDALTYAWTQTAGP-TVTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRNVNRAP-VAHAG 1475

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   734 GRhVLILPNNSITLDGSRSTDDRGIVSYLWIRDGQSP-------AAGDVIGGSDHRAALQLTnlvegvytFHLLVTDSQG 806
Cdd:NF038112 1476 ES-ITVDEGSTVTLDASATDPDGDTLTYAWTQVAGPSvtltgadSAKLTFTAPEVSADTTLT--------FSLTVTDGSG 1546

                         410
                  ....*....|....*....
gi 81871948   807 ASDSDAATVEVLPDPKKDG 825
Cdd:NF038112 1547 SSGPVVVTVTVKNVNRAPD 1565
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 429-741 2.71e-32

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 136.71  E-value: 2.71e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   429 VNVTVmpaARVNQPPVAVVS-PQTQELSVPLTsalIDGSQSTDDTEIVSYHWEEVDGP-------------FLGEEFPAD 494
Cdd:NF038112 1272 VTVLV---RNVNRAPVAVAGaPATVDERSTVT---LDGSGTDADGDALTYAWTQTSGPavtltgattatatFTAPEVTAD 1345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   495 TPIlrlsnlvpgnyTFRLTITDSdGATNSTTASLVIRDaVDYPPVANAGPNQTITlPQNTIILNGNQSSDDHQIVLYEWF 574
Cdd:NF038112 1346 TQL-----------TFTLTVSDG-TASATDTVTVTVRN-VNRAPVANAGADQTVD-ERSTVTLSGSATDPDGDALTYAWT 1411

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   575 --AGPGGEskemvMQGAQTPYLHL---SELQEGEYTFQLMVTdsSGQQSTALVAVTVQAEN-NQAPVAVAGPDKElVFPV 648
Cdd:NF038112 1412 qtAGPTVT-----LTGADTATASFtapEVAADTELTFQLTVS--ADGQASADVTVTVTVRNvNRAPVAHAGESIT-VDEG 1483

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948   649 QSATLDGSRSSDDHGIVCYHWEHIRGPSaVEMENVDKAIATVTGLQVG---IYHFRLTVRDQQGLSSTSTLTVAVKKENN 725
Cdd:NF038112 1484 STVTLDASATDPDGDTLTYAWTQVAGPS-VTLTGADSAKLTFTAPEVSadtTLTFSLTVTDGSGSSGPVVVTVTVKNVNR 1562

                         330
                  ....*....|....*....
gi 81871948   726 SPPR---AQAGGRHVLILP 741
Cdd:NF038112 1563 APDGggcSSTGGSPGGMLP 1581
MANEC smart00765
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ...
 23-102 1.15e-12

The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.


Pssm-ID: 129004  Cd Length: 93  Bit Score: 64.78  E-value: 1.15e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948      23 QQCSEG-RTYSDAIISPNPETIRIMRV----SQTFSVGDCTAACCDLLTCDLAWWF------EGSCYLVKCMRS--ENCE 89
Cdd:smart00765    4 EDCLGRfRVLENAIIRTEESLSAGARFlkspIAVNTWEDCVRACCSTPNCNLAVFElrredaEGNCYLFNCTYPgkEVCK 83

                            90
                    ....*....|...
gi 81871948      90 prtTGPIRSYLTF 102
Cdd:smart00765   84 ---FKPHEGYTSY 93
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 379-618 4.10e-08

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 57.13  E-value: 4.10e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    379 YEWSLMSHPVDFqGKIKQENKPTLHLSQ-------LSVGLYAFRVAVSSE---NAFGEGYVNVTVMPAarvnqPPVAVVS 448
Cdd:pfam02010   16 YLWSVFTVSSNL-NLQTISSPKDLVLPQltipsgtLPYGTYVFTLTVSLSstpSLAGTDIITVTVQPS-----PLVAVID 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    449 PQTqELSVPLTSALI-DGSQSTD------DTEIVSYHWEEVDGPFL--------GEEFPADTPILRL-----------SN 502
Cdd:pfam02010   90 GGS-SRVVGYNQDLTlDGSESYDpdvdpgSSSGLTYLWSCRRSSSGdnpllnndPVCFSDQNEGTLLqstsssltipaST 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    503 LVPG-NYTFRLTITDSDGATNSTTASLVIRDavDYPP------VANAgpNQTITLPQNTIILNG--NQSSDDHQIVLYEW 573
Cdd:pfam02010  169 LQANvTYTFKLTVSKGSRNSASTTQTILVVD--GNPPiiilscISNC--NRKNNPVDRLVLLAStcLNCSSDLSDVTYRW 244

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 81871948    574 FAGPGGESKEM-------VMQGAQTPYLHLSE--LQEG-EYTFQLMVTDSSGQQS 618
Cdd:pfam02010  245 LSLGSENTSLVldqlnsqTSTGRSGPYLVIKAgvLQSGvSYRFTLIVTVYPGLVS 299
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 631-720 4.84e-08

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 51.50  E-value: 4.84e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    631 NQAPVAVAGPDKElVFPVQSATLDGSRSSD-DHGIVCYHWEHIRGpSAVEMENVDKAIATvtglqVGIYHFRLTVRDQQG 709
Cdd:pfam18911    1 NAAPVADAGGDRI-VAEGETVTFDASASDDpDGDILSYRWDFGDG-TTATGANVSHTYAA-----PGTYTVTLTVTDDSG 73

                           90
                   ....*....|..
gi 81871948    710 LS-STSTLTVAV 720
Cdd:pfam18911   74 ASnSTATDTVTV 85
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 444-530 1.34e-07

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 49.76  E-value: 1.34e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948     444 VAVVSPQTQELSVPLTSALIDgsQSTDDTEIVSYHWEEVDGPFLGEefpadtPILRLSNLVPGNYTFRLTITDSDGaTNS 523
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTA--TSSDDGSIVSYTWDFGDGTSSTG------PTVTHTYTKPGTYTVTLTVTNAVG-SAS 71


                    ....*..
gi 81871948     524 TTASLVI 530
Cdd:smart00089   72 ATVTVVV 78
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 635-721 1.49e-07

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 49.76  E-value: 1.49e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948     635 VAVAGPDKELVFPVQSATLDGSrSSDDHGIVCYHWEHIRGPSAVEmenvdkAIATVTGLQVGIYHFRLTVRDQQGlSSTS 714
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTAT-SSDDGSIVSYTWDFGDGTSSTG------PTVTHTYTKPGTYTVTLTVTNAVG-SASA 72


                    ....*..
gi 81871948     715 TLTVAVK 721
Cdd:smart00089   73 TVTVVVQ 79
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 635-720 9.95e-07

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 47.49  E-value: 9.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948  635 VAVAGPDKELVFPVQSATLDGSrSSDDHGIVCYHWehIRGPSAVEMENVdkAIATVTGLQVGIYHFRLTVRDQQGLSSTS 714
Cdd:cd00146    1 PTASVSAPPVAELGASVTFSAS-DSSGGSIVSYKW--DFGDGEVSSSGE--PTVTHTYTKPGTYTVTLTVTNAVGSSSTK 75


                 ....*.
gi 81871948  715 TLTVAV 720
Cdd:cd00146   76 TTTVVV 81
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 537-626 3.02e-06

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 46.11  E-value: 3.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    537 PPVANAGPNQTITLPQnTIILNGNQSSD-DHQIVLYEWFAGPGGESkemvmQGAQTPYLHlseLQEGEYTFQLMVTDSSG 615
Cdd:pfam18911    3 APVADAGGDRIVAEGE-TVTFDASASDDpDGDILSYRWDFGDGTTA-----TGANVSHTY---AAPGTYTVTLTVTDDSG 73

                           90
                   ....*....|..
gi 81871948    616 -QQSTALVAVTV 626
Cdd:pfam18911   74 aSNSTATDTVTV 85
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 590-812 5.60e-06

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 50.19  E-value: 5.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    590 QTPYLHLSE--LQEGEYTFQLMVT--DSSGQQSTALVAVTVQAennqAP-VAVAGPDKELVFPVQSA-TLDGSRSSD--- 660
Cdd:pfam02010   39 VLPQLTIPSgtLPYGTYVFTLTVSlsSTPSLAGTDIITVTVQP----SPlVAVIDGGSSRVVGYNQDlTLDGSESYDpdv 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    661 ---DHGIVCYHWEHIRGPSAVE-MENVD----------------KAIATVTG--LQVG-IYHFRLTVRDQQGLSSTSTLT 717
Cdd:pfam02010  115 dpgSSSGLTYLWSCRRSSSGDNpLLNNDpvcfsdqnegtllqstSSSLTIPAstLQANvTYTFKLTVSKGSRNSASTTQT 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    718 VAVKKENnsPPRAqaggrHVLILPNNSITLD--------GSRSTDDRG---IVSYLWIRDG------------QSPAAGD 774
Cdd:pfam02010  195 ILVVDGN--PPII-----ILSCISNCNRKNNpvdrlvllASTCLNCSSdlsDVTYRWLSLGsentslvldqlnSQTSTGR 267

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 81871948    775 viggSDHRAALQLTNLVEGV-YTFHLLVTDSQGASDSDA 812
Cdd:pfam02010  268 ----SGPYLVIKAGVLQSGVsYRFTLIVTVYPGLVSGLA 302
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 440-524 6.11e-06

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 45.34  E-value: 6.11e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    440 NQPPVAVVSPqTQELSVPLTSALiDGSQSTD-DTEIVSYHWEEVDGPFLGEE-----FPAdtpilrlsnlvPGNYTFRLT 513
Cdd:pfam18911    1 NAAPVADAGG-DRIVAEGETVTF-DASASDDpDGDILSYRWDFGDGTTATGAnvshtYAA-----------PGTYTVTLT 67

                           90
                   ....*....|.
gi 81871948    514 ITDSDGATNST 524
Cdd:pfam18911   68 VTDDSGASNST 78
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 728-817 1.36e-05

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 44.41  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948  728 PRAQAGGRHVLILpNNSITLDGSRSTDDRgIVSYLWIRDGqspaaGDVIGGSDHRAalQLTNLVEGVYTFHLLVTDSQGA 807
Cdd:cd00146    1 PTASVSAPPVAEL-GASVTFSASDSSGGS-IVSYKWDFGD-----GEVSSSGEPTV--THTYTKPGTYTVTLTVTNAVGS 71

                         90
                 ....*....|
gi 81871948  808 SDSDAATVEV 817
Cdd:cd00146   72 SSTKTTTVVV 81
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 442-530 2.51e-05

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 43.64  E-value: 2.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948  442 PPVAVVSPQTQELSVPLT-SAlidgsQSTDDTEIVSYHWEEVDGPFLGEEfpadTPILRLSNLVPGNYTFRLTITDSDGA 520
Cdd:cd00146    1 PTASVSAPPVAELGASVTfSA-----SDSSGGSIVSYKWDFGDGEVSSSG----EPTVTHTYTKPGTYTVTLTVTNAVGS 71

                         90
                 ....*....|
gi 81871948  521 TNSTTASLVI 530
Cdd:cd00146   72 SSTKTTTVVV 81
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 729-817 2.91e-05

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 43.21  E-value: 2.91e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948     729 RAQAGGRHVLILPNNSITLDGSrSTDDRGIVSYLWirdgqspaagDVIGGSDHRAA-LQLTNLVEGVYTFHLLVTDSQGa 807
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTAT-SSDDGSIVSYTW----------DFGDGTSSTGPtVTHTYTKPGTYTVTLTVTNAVG- 68

                            90
                    ....*....|
gi 81871948     808 SDSDAATVEV 817
Cdd:smart00089   69 SASATVTVVV 78
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 725-817 1.41e-04

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 41.49  E-value: 1.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    725 NSPPRAQAGGRhVLILPNNSITLDGSRSTD-DRGIVSYLW-IRDGQSPAAGDViggsDHRAAlqltnlVEGVYTFHLLVT 802
Cdd:pfam18911    1 NAAPVADAGGD-RIVAEGETVTFDASASDDpDGDILSYRWdFGDGTTATGANV----SHTYA------APGTYTVTLTVT 69

                           90
                   ....*....|....*.
gi 81871948    803 DSQGASDS-DAATVEV 817
Cdd:pfam18911   70 DDSGASNStATDTVTV 85
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 539-627 7.25e-04

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 39.36  E-value: 7.25e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948     539 VANAGPNQTITLPQNTIILNGnQSSDDHQIVLYEWFAGPGGESKEmvmqgaqtPYLHLSELQEGEYTFQLMVTDSSGqQS 618
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTA-TSSDDGSIVSYTWDFGDGTSSTG--------PTVTHTYTKPGTYTVTLTVTNAVG-SA 70


                    ....*....
gi 81871948     619 TALVAVTVQ 627
Cdd:smart00089   71 SATVTVVVQ 79
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 538-626 1.32e-03

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 38.63  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948  538 PVANAGPNQTITLPQNtIILNGNqSSDDHQIVLYEWFAGPGGESkemvMQGAQTPylHLSELQEGEYTFQLMVTDSSGQQ 617
Cdd:cd00146    1 PTASVSAPPVAELGAS-VTFSAS-DSSGGSIVSYKWDFGDGEVS----SSGEPTV--THTYTKPGTYTVTLTVTNAVGSS 72


                 ....*....
gi 81871948  618 STALVAVTV 626
Cdd:cd00146   73 STKTTTVVV 81
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 284-571 2.90e-03

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 41.33  E-value: 2.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    284 NPSPASLESSPATTEKNSNFTVTPRSRKHSTPTFPTS-TVLTGLTPPPwplsptasrTVKALAVSAgDNLVLTLPDREAe 362
Cdd:pfam02010  156 QSTSSSLTIPASTLQANVTYTFKLTVSKGSRNSASTTqTILVVDGNPP---------IIILSCISN-CNRKNNPVDRLV- 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    363 LKASVEPAPPADT-TYSYEWSLMSHPVDFQGKIKQENKPTLHLSQ---------LSVGL-YAFRVAVSSENAFGEGYVNV 431
Cdd:pfam02010  225 LLASTCLNCSSDLsDVTYRWLSLGSENTSLVLDQLNSQTSTGRSGpylvikagvLQSGVsYRFTLIVTVYPGLVSGLASI 304

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    432 TVmpaaRVNQPP------------VAVVSPQTQ------ELSVPLTSALIDGSQSTDDTE--IVSYHWEEVDGPFLgeeF 491
Cdd:pfam02010  305 SF----ITNAPPtggtcsvtptegTALETKFTVtcqgwtDDDLPLTYQFGDISFREASEEwfLLYEGSSQISISTF---L 377

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81871948    492 PadtpilrlSNLVPGNYTFRL--TITDSDGATNSTTASLVIRdavdyPPVANAGPNQTITLPQNTiiLNGNQSSDDHQIV 569
Cdd:pfam02010  378 P--------PGLPANDYQVTVvvVVYDSLGAATSVSLTITVT-----PPSSSDELLYFLLGTTSD--LSALLQSGDPQQA 442


                   ..
gi 81871948    570 LY 571
Cdd:pfam02010  443 AQ 444
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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