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Conserved domains on  [gi|1835884573|sp|Q5NUL3|]
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RecName: Full=Free fatty acid receptor 4; AltName: Full=G-protein coupled receptor 120; AltName: Full=G-protein coupled receptor 129; AltName: Full=G-protein coupled receptor GT01; AltName: Full=G-protein coupled receptor PGR4; AltName: Full=Omega-3 fatty acid receptor 1

Protein Classification

G-protein coupled receptor( domain architecture ID 11535993)

G-protein coupled receptor transmits physiological signals from the outside of the cell to the inside via G proteins by binding to an extracellular agonist, which induces conformational changes that lead to the activation of heterotrimeric G proteins, which then bind to and activate numerous downstream effector proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
43-321 8.56e-42

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


:

Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 147.05  E-value: 8.56e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  43 ETTVLVLIFAVSLLGNVCALVLVARRRRRG-ATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTL 120
Cdd:cd00637     1 LAVLYILIFVVGLVGNLLVILVILRNRRLRtVTNYFILNLAVADLLVgLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 121 SGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPqrlpgaDQEISICTLIWPT 200
Cdd:cd00637    81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYD------YGGYCCCCLCWPD 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 201 IPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRltVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPI 280
Cdd:cd00637   155 LTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRR--IRSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPY 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1835884573 281 IITILLILIQNFKQDLVIWpsLFFWVVAFTFANSALNPILY 321
Cdd:cd00637   233 FILLLLDVFGPDPSPLPRI--LYFLALLLAYLNSAINPIIY 271
 
Name Accession Description Interval E-value
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
43-321 8.56e-42

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 147.05  E-value: 8.56e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  43 ETTVLVLIFAVSLLGNVCALVLVARRRRRG-ATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTL 120
Cdd:cd00637     1 LAVLYILIFVVGLVGNLLVILVILRNRRLRtVTNYFILNLAVADLLVgLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 121 SGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPqrlpgaDQEISICTLIWPT 200
Cdd:cd00637    81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYD------YGGYCCCCLCWPD 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 201 IPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRltVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPI 280
Cdd:cd00637   155 LTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRR--IRSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPY 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1835884573 281 IITILLILIQNFKQDLVIWpsLFFWVVAFTFANSALNPILY 321
Cdd:cd00637   233 FILLLLDVFGPDPSPLPRI--LYFLALLLAYLNSAINPIIY 271
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
73-321 7.19e-27

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 107.00  E-value: 7.19e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  73 ATACLVLNLFCADLLF-ISAIPLVLA-VRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVH-LQRGVRG 149
Cdd:pfam00001  18 PTNIFLLNLAVADLLFsLLTLPFWLVyYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHpLRYKRRR 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 150 PGRRArAVLLALIWGYSAVAALPlCVFFRvvpQRLPGADQEISICTLIWPTIPG-EISWDVSFVTLNFLVPGLVIVISYS 228
Cdd:pfam00001  98 TPRRA-KVLILVIWVLALLLSLP-PLLFG---WTLTVPEGNVTVCFIDFPEDLSkPVSYTLLISVLGFLLPLLVILVCYT 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 229 KILQITKASRKRLTVSlayseshqiRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVA 308
Cdd:pfam00001 173 LIIRTLRKSASKQKSS---------ERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLLDKALSVTLW 243
                         250
                  ....*....|...
gi 1835884573 309 FTFANSALNPILY 321
Cdd:pfam00001 244 LAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
44-239 3.76e-09

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 57.48  E-value: 3.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHL---LFYVMTL 120
Cdd:PHA03087   44 IVVYSTIFFFGLVGNIIVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIvsgLYYIGFY 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 121 SGsvtILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVvpqrlpGADQEISIC------ 194
Cdd:PHA03087  124 NS---MNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTT------KKDHETLICcmfynn 194
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1835884573 195 -TLIWPTIpgeISWDVSFvtLNFLVPGLVIVISYSKILQITKASRK 239
Cdd:PHA03087  195 kTMNWKLF---INFEINI--IGMLIPLTILLYCYSKILITLKGINK 235
 
Name Accession Description Interval E-value
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
43-321 8.56e-42

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 147.05  E-value: 8.56e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  43 ETTVLVLIFAVSLLGNVCALVLVARRRRRG-ATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTL 120
Cdd:cd00637     1 LAVLYILIFVVGLVGNLLVILVILRNRRLRtVTNYFILNLAVADLLVgLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 121 SGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPqrlpgaDQEISICTLIWPT 200
Cdd:cd00637    81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYD------YGGYCCCCLCWPD 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 201 IPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRltVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPI 280
Cdd:cd00637   155 LTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRR--IRSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPY 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1835884573 281 IITILLILIQNFKQDLVIWpsLFFWVVAFTFANSALNPILY 321
Cdd:cd00637   233 FILLLLDVFGPDPSPLPRI--LYFLALLLAYLNSAINPIIY 271
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
73-321 7.19e-27

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 107.00  E-value: 7.19e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  73 ATACLVLNLFCADLLF-ISAIPLVLA-VRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVH-LQRGVRG 149
Cdd:pfam00001  18 PTNIFLLNLAVADLLFsLLTLPFWLVyYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHpLRYKRRR 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 150 PGRRArAVLLALIWGYSAVAALPlCVFFRvvpQRLPGADQEISICTLIWPTIPG-EISWDVSFVTLNFLVPGLVIVISYS 228
Cdd:pfam00001  98 TPRRA-KVLILVIWVLALLLSLP-PLLFG---WTLTVPEGNVTVCFIDFPEDLSkPVSYTLLISVLGFLLPLLVILVCYT 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 229 KILQITKASRKRLTVSlayseshqiRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVA 308
Cdd:pfam00001 173 LIIRTLRKSASKQKSS---------ERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLLDKALSVTLW 243
                         250
                  ....*....|...
gi 1835884573 309 FTFANSALNPILY 321
Cdd:pfam00001 244 LAYVNSCLNPIIY 256
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
44-321 6.21e-25

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 102.68  E-value: 6.21e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGN--VCALVLVARRRRRGATACLVlNLFCADLLFIS-AIPLVLAVRWTEAWLLGPVACHLLFYVMTL 120
Cdd:cd14993     4 IVLYVVVFLLALVGNslVIAVVLRNKHMRTVTNYFLV-NLAVADLLVSLfCMPLTLLENVYRPWVFGEVLCKAVPYLQGV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 121 SGSVTILTLAAVSLERMVCIVH-LQRGVRGPGRRARAVLLAlIWGYSAVAALPLCVFFRVVPQRLPGAD-QEISICTLIW 198
Cdd:cd14993    83 SVSASVLTLVAISIDRYLAICYpLKARRVSTKRRARIIIVA-IWVIAIIIMLPLLVVYELEEIISSEPGtITIYICTEDW 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 199 PTIPGEISWDVSFVTLNFLVPGLVIVISYSKILqITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWS 278
Cdd:cd14993   162 PSPELRKAYNVALFVVLYVLPLLIISVAYSLIG-RRLWRRKPPGDRGSANSTSSRRILRSKKKVARMLIVVVVLFALSWL 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1835884573 279 P-----IIITILLILIQNFKQDLVIWPSLFFWvvaFTFANSALNPILY 321
Cdd:cd14993   241 PyyvlsILLDFGPLSSEESDENFLLILPFAQL---LGYSNSAINPIIY 285
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
73-321 2.43e-24

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 100.83  E-value: 2.43e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  73 ATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVH--LQRGVRGP 150
Cdd:cd14970    34 VTNIYILNLAVADELFLLGLPFLATSYLLGYWPFGEVMCKIVLSVDAYNMFTSIFCLTVMSVDRYLAVVHpvKSLRFRTP 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 151 gRRARAVLLaLIWGYSAVAALPLCVFFRVVPqrlpgADQEISICTLIWPTIPGeiSWDVSFVT----LNFLVPGLVIVIS 226
Cdd:cd14970   114 -RKAKLVSL-CVWALSLVLGLPVIIFARTLQ-----EEGGTISCNLQWPDPPD--YWGRVFTIytfvLGFAVPLLVITVC 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 227 YSKILQITKASRKRLTVSLAYSESHQIRVSqqdfrlfRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLViWPSLFFWV 306
Cdd:cd14970   185 YSLIIRRLRSSRNLSTSGAREKRRARRKVT-------RLVLVVVAVFVVCWLPFHVFQIVRLLIDPPETLT-VVGVFLFC 256
                         250
                  ....*....|....*
gi 1835884573 307 VAFTFANSALNPILY 321
Cdd:cd14970   257 IALSYANSCLNPILY 271
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
49-321 1.75e-23

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 98.45  E-value: 1.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  49 LIFAVSLLGNVCALVLVARR-RRRGATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTI 126
Cdd:cd15203     9 LIIVLGVVGNLLVIYVVLRNkSMQTVTNIFILNLAVSDLLLcLVSLPFTLIYTLTKNWPFGSILCKLVPSLQGVSIFVST 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 127 LTLAAVSLERMVCIVHLQRgvRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEIS 206
Cdd:cd15203    89 LTLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLLLSLPLAIFQELSDVPIEILPYCGYFCTESWPSSSSRLI 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 207 WDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILL 286
Cdd:cd15203   167 YTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKRGKRTLSSRRRRSELRRKRRTNRLLIAMVVVFAVCWLPLNLFNLL 246
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1835884573 287 ILIQNFKQDLVIWPSLFFWVV-AFTFANSALNPILY 321
Cdd:cd15203   247 RDFEPLPQIDGRHFYLIFLIChLIAMSSACVNPLLY 282
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
44-322 8.51e-23

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 95.71  E-value: 8.51e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCALVLVARRRRRG-ATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLS 121
Cdd:cd14967     3 AVFLSLIILVTVFGNLLVILAVYRNRRLRtVTNYFIVSLAVADLLVaLLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLC 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 122 GSVTILTLAAVSLERMVCIVH-LQRGVRGPGRRArAVLLALIWGYSAVAALPLCVFFRVVPQrlpgadqeISICTLIWPT 200
Cdd:cd14967    83 CTASILNLCAISLDRYLAITRpLRYRQLMTKKRA-LIMIAAVWVYSLLISLPPLVGWRDETQ--------PSVVDCECEF 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 201 IPGEISWDVSFVtLNFLVPGLVIVISYSKILqitkasrkrltvslayseshqiRVSQQDFRLFRTLFLLMVSFFIMWSPI 280
Cdd:cd14967   154 TPNKIYVLVSSV-ISFFIPLLIMIVLYARIF----------------------RVARRELKAAKTLAIIVGAFLLCWLPF 210
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1835884573 281 IITILLILIQNFKQDLVIWPSLFFWVVaftFANSALNPILYN 322
Cdd:cd14967   211 FIIYLVSAFCPPDCVPPILYAVFFWLG---YLNSALNPIIYA 249
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-333 1.40e-21

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 92.89  E-value: 1.40e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGNV-CALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGS 123
Cdd:cd14999     4 TVLSLMCVVGVAGNVyTLVVMCLSMRPRASMYVYILNLALADLLYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFLTMH 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 124 VTILTLAAVSLERMVCIVHLQRGVRGPGRRARAvLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEiSICTLIWPTIPG 203
Cdd:cd14999    84 ASIFTLTVMSTERYLAVVKPLDTVKRSKSYRKL-LAGVIWLLSLLLTLPMAIMIRLVTVEDKSGGSK-RICLPTWSEESY 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 204 EISWDVSFVTlNFLVPGLVIVISYSKILQITKASRKRLTVSLAYSESHQirvsqqdfRLFRTLFLLMVSFFIMWSPIIIT 283
Cdd:cd14999   162 KVYLTLLFST-SIVIPGLVIGYLYIRLARKYWLSQAAASNSSRKRLPKQ--------KVLKMIFTIVLVFWACFLPFWIW 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1835884573 284 ILLILIQNFKQ--DLVIwPSLFFWVVAFTFANSALNPILYnmTLCRNEWKKI 333
Cdd:cd14999   233 QLLYLYSPSLSlsPRTT-TYVNYLLTCLTYSNSCINPFLY--TLLTKNYKEY 281
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
44-322 6.60e-20

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 88.54  E-value: 6.60e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCALVLVARRRRR-GATACLVLNLFCADLLF-ISAIPLVLAVRWTE-AWLLGPVACHLLFYVMTL 120
Cdd:cd15134     4 TIIYGIIFVTGVVGNLCTCIVIARNRSMhTATNYYLFSLAVSDLLLlILGLPFELYTIWQQyPWVFGEVFCKLRAFLSEM 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 121 SGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEIS----ICTL 196
Cdd:cd15134    84 SSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAIQTRIVYLEYPPTSGEALeesaFCAM 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 197 IWPTIPGEISWDVSFvTLNFLVPGLVIVISYSKI-LQITKASRKRLTVSLAYSESHQirvSQQDFRLFRTLFLLMVSFFI 275
Cdd:cd15134   164 LNEIPPITPVFQLST-FLFFIIPMIAIIVLYVLIgLQLRRSTLLRRGQRSVSGGRRS---SQSRRTVLRMLVAVVVAFFI 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1835884573 276 MWSP-------IIITILLILIQNFKQDLVIWPSLFFWvvaftFANSALNPILYN 322
Cdd:cd15134   240 CWAPfhaqrllTVYAKNMTPPYLFINRILFYISGVLY-----YVSSTVNPILYN 288
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
42-279 1.23e-19

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 87.65  E-value: 1.23e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  42 VETTVLVLIFAVSLLGNVCALVLVA-RRRRRGATACLVLNLFCADLLFIS-AIPLVLAVRWTEAWLLGPVACHLLFYVMT 119
Cdd:cd14969     2 VLAVYLSLIGVLGVVLNGLVIIVFLkKKKLRTPLNLFLLNLALADLLMSVvGYPLSFYSNLSGRWSFGDPGCVIYGFAVT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 120 LSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRArAVLLALIWGYSAV-AALPLCVFFRVVPQRLPgadqeiSICTLIW 198
Cdd:cd14969    82 FLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRA-LILIAFIWLYGLFwALPPLFGWSSYVPEGGG------TSCSVDW 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 199 -PTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTVSLAYSESHQIRVSQQdfRLFRTLFLLMVSFFIMW 277
Cdd:cd14969   155 ySKDPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTKKAEK--KVAKMVLVMIVAFLIAW 232

                  ..
gi 1835884573 278 SP 279
Cdd:cd14969   233 TP 234
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
48-321 1.29e-18

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 84.98  E-value: 1.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  48 VLIFAVSLLGN--VCALVLVARRRRrGATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSV 124
Cdd:cd15207     8 SLIFLLCVVGNvlVCLVVAKNPRMR-TVTNYFILNLAVSDLLVgVFCMPFTLVDNILTGWPFGDVMCKLSPLVQGVSVAA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 125 TILTLAAVSLERMVCIVHLQRGvRGPGRRARAVlLALIWGYSAVAALPLcVFFRVVPQRLPGADQEISICTLIWPTIPGE 204
Cdd:cd15207    87 SVFTLVAIAVDRYRAVVHPTEP-KLTNRQAFVI-IVAIWVLALAIMIPQ-ALVLEVKEYQFFRGQTVHICVEFWPSDEYR 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 205 ISWDVSFVTLNFLVPGLVIVISYSKIlqITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITI 284
Cdd:cd15207   164 KAYTTSLFVLCYVAPLLIIAVLYVRI--GYRLWFKPVPGGGSASREAQAAVSKKKVRVIKMLIVVVVLFALSWLPLHTVT 241
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1835884573 285 LLILIQNF--KQDLVIWPSLFFWVVAFTFANSALNPILY 321
Cdd:cd15207   242 MLDDFGNLspNQREVLYVYIYPIAHWLAYFNSCVNPIVY 280
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
77-321 1.21e-17

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 81.94  E-value: 1.21e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRgPGRRAR 155
Cdd:cd15074    38 LTVNLAVSDLGIsVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSINTLTAISIYRYLKICHPPYGPK-LSRRHV 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 156 AVLLALIWGYSAV-AALPLCVFFRVVPQRLPGAdqeisiCTLIW---PTIPGEISWDVSFVTLNFLVPGLVIVISYSKIL 231
Cdd:cd15074   117 CIVIVAIWLYALFwAVAPLVGWGSYGPEPFGTS------CSIDWtgaSASVGGMSYIISIFIFCYLLPVLIIVFSYVKII 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 232 QITKASRKRltvsLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQnfKQDLViwPSLFFwVVAFTF 311
Cdd:cd15074   191 RKVKSSRKR----VAGFDSRSKRQHKIERKVTKVAVLICAGFLIAWTPYAVVSMWSAFG--SPDSV--PILAS-ILPALF 261
                         250
                  ....*....|..
gi 1835884573 312 A--NSALNPILY 321
Cdd:cd15074   262 AksSCMYNPIIY 273
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
73-322 6.53e-17

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 80.02  E-value: 6.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  73 ATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPG 151
Cdd:cd15095    34 VTNYYIVNLAVTDLAFlVCCVPFTAALYATPSWVFGDFMCKFVNYMMQVTVQATCLTLTALSVDRYYAIVHPIRSLRFRT 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 152 RRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGaDQeiSICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKIL 231
Cdd:cd15095   114 PRVAVVVSACIWIVSFLLSIPVAIYYRLEEGYWYG-PQ--TYCREVWPSKAFQKAYMIYTVLLTYVIPLAIIAVCYGLIL 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 232 qitKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPI-IITILLILIQNFKQDLVIWpSLFFWVVAFT 310
Cdd:cd15095   191 ---RRLWRRSVDGNNQSEQLSERALRQKRKVTRMVIVVVVLFAICWLPNhVLNLWQRFDPNFPETYATY-ALKIAALCLS 266
                         250
                  ....*....|..
gi 1835884573 311 FANSALNPILYN 322
Cdd:cd15095   267 YANSAVNPFVYA 278
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
44-323 9.63e-17

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 79.71  E-value: 9.63e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVL-NLFCADLL-FISAIPLVLAVRW-TEAWLLGPVACHLLFYVMTL 120
Cdd:cd14979     4 TAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLfSLAVSDLLiLLVGLPVELYNFWwQYPWAFGDGGCKLYYFLFEA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 121 SGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQR--LPGADQEISICTLIW 198
Cdd:cd14979    84 CTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQYLNgpLPGPVPDSAVCTLVV 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 199 PTIPGEISWDVSFvTLNFLVPGLVIVISYSKIL-------QITKASRKRLTVSLAYSESHQIRVsqqdfRLFRTLFLLMV 271
Cdd:cd14979   164 DRSTFKYVFQVST-FIFFVLPMFVISILYFRIGvklrsmrNIKKGTRAQGTRNVELSLSQQARR-----QVVKMLGAVVI 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1835884573 272 SFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTF--ANSALNPILYNM 323
Cdd:cd14979   238 AFFVCWLPFHAQRLMFSYASKEDTFLFDFYQYLYPISGILfyLSSAINPILYNL 291
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
45-321 3.62e-16

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 77.80  E-value: 3.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGN-VCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEA-WLLGPVACHLLFYVMTLSG 122
Cdd:cd14985     5 ALYIAIFLVGLLGNlFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANQYdWPFGAFLCKVSSYVISVNM 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 123 SVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVvpQRLPGADqeISICTLIWPTIP 202
Cdd:cd14985    85 FASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSL--QAIENLN--KTACIMLYPHEA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 203 GEISWDVSFVTLNFLVPGLVIVISYSKILQitkasrkrltvSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIII 282
Cdd:cd14985   161 WHFGLSLELNILGFVLPLLIILTCYFHIAR-----------SLRKRYERTGKNGRKRRKSLKIIFALVVAFLVCWLPFHF 229
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1835884573 283 TILLILIQNFKQDLVIWPSLFF-----WVVAFTFANSALNPILY 321
Cdd:cd14985   230 FKFLDFLAQLGAIRPCFWELFLdlglpIATCLAFTNSCLNPFIY 273
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
49-321 4.73e-16

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 77.51  E-value: 4.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  49 LIFAVSLLGN-VCALVLVARRRRRGATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTI 126
Cdd:cd14971     9 LIFLLGLVGNsLVILVVARNKPMRSTTNLFILNLAVADLTFlLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSMHASI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 127 LTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLpgadQEISICTLIWPTIPGEIS 206
Cdd:cd14971    89 FTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTP----GNRTVCSEAWPSRAHRRA 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 207 WDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTVSlAYSESHQIRVSqqdfrlfRTLFLLMVSFFIMWSPiiiTILL 286
Cdd:cd14971   165 FALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLS-EGSRRAKRKVT-------RLVLVVVVLFAACWGP---IHAI 233
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1835884573 287 ILIQNFKQDLVIWPSLFFWVVAFT--FANSALNPILY 321
Cdd:cd14971   234 LLLVALGPFPLTYATYALRIWAHClaYSNSAVNPVLY 270
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
73-321 1.35e-14

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 73.27  E-value: 1.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  73 ATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGR 152
Cdd:cd15093    34 VTNIYILNLAIADELFMLGLPFLAASNALRHWPFGSVLCRLVLSVDGINMFTSIFCLTVMSVDRYLAVVHPIKSARWRRP 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 153 RARAVLLALIWGYSAVAALPLCVFFRVVPQRlpgadQEISICTLIWPTIPGeiSWDVSFV----TLNFLVPGLVIVISYS 228
Cdd:cd15093   114 RVAKVVNLAVWVASLLVILPVVVFAGTRENQ-----DGSSACNMQWPEPAA--AWSAGFIiytfVLGFLLPLLIICLCYL 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 229 KILQITKASRKRLTvslayseSHQIRVSQQdfRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIwPSLFFWVVA 308
Cdd:cd15093   187 LIVIKVKSAGLRAG-------WQQRKRSER--KVTRMVVMVVVVFVICWLPFYVLQLVNVFVQLPETPAL-VGVYHFVVI 256
                         250
                  ....*....|...
gi 1835884573 309 FTFANSALNPILY 321
Cdd:cd15093   257 LSYANSCANPILY 269
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
42-321 1.71e-14

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 72.72  E-value: 1.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  42 VETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLA-VRWTEAWLLGPVACHLLFYVMTL 120
Cdd:cd14974     2 VSLVLYALIFLLGLPGNGLVIWVAGFKMKRTVNTVWFLNLALADFLFCLFLPFLIVyIAMGHHWPFGSVLCKLNSFVISL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 121 SGSVTILTLAAVSLERMVCIVH--LQRGVRGPGRRARAVLlaLIWGYSAVAALPLCVFFRVVpQRLPGADQEISICTLIW 198
Cdd:cd14974    82 NMFASVFLLTAISLDRCLLVLHpvWAQNHRTVRLASVVCV--GIWILALVLSVPYFVFRDTV-THHNGRSCNLTCVEDYD 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 199 PTIPGEISWDVSFVTLNFLVPGLVIVISYSKIlqITKASRKRLTVSLayseshqirvsqqdfRLFRTLFLLMVSFFIMWS 278
Cdd:cd14974   159 LRRSRHKALTVIRFLCGFLLPLLIIAICYSVI--AVKLRRKRLAKSS---------------KPLRVLLAVVVAFFLCWL 221
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1835884573 279 PIIITILLILIQNFKQDLVIWPSLFFwVVAFTFANSALNPILY 321
Cdd:cd14974   222 PYHVFALLELVAAAGLPEVVLLGLPL-ATGLAYFNSCLNPILY 263
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
48-321 2.23e-14

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 72.78  E-value: 2.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  48 VLIFAVSLLGN--VCALVLVARRRRRgATACLVLNLFCADLLF-ISAIPLVL-AVRWTEAWLLGPVACHLLFYVMTLSGS 123
Cdd:cd15392     8 STIFVLAVGGNglVCYIVVSYPRMRT-VTNYFIVNLALSDILMaVFCVPFSFiALLILQYWPFGEFMCPVVNYLQAVSVF 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 124 VTILTLAAVSLERMVCIVHLQRgvRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQeiSICTLIWPTIPG 203
Cdd:cd15392    87 VSAFTLVAISIDRYVAIMWPLR--PRMTKRQALLLIAVIWIFALATALPIAITSRLFEDSNASCGQ--YICTESWPSDTN 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 204 EISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTVslaySESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIIT 283
Cdd:cd15392   163 RYIYSLVLMILQYFVPLAVLVFTYTRIGIVVWAKRTPGEA----ENNRDQRMAESKRKLVKMMITVVAIFALCWLPLNIL 238
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1835884573 284 ILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILY 321
Cdd:cd15392   239 NLVGDHDESIYSWPYIPYLWLAAHWLAMSHCCYNPFIY 276
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
49-279 2.26e-14

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 72.42  E-value: 2.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  49 LIFAVSLLGNVCALVLVAR-RRRRGATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTI 126
Cdd:cd15206     9 VIFLLAVVGNILVIVTLVQnKRMRTVTNVFLLNLAVSDLLLaVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSVSVST 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 127 LTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQeisiCTLIWPTIPGEIS 206
Cdd:cd15206    89 FTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPGGHK----CREVWPNEIAEQA 164
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1835884573 207 WDVSFVTLNFLVPGLVIVISYSKIlqitkasrkrltvslayseSHQIRVSQQdfRLFRTLFLLMVSFFIMWSP 279
Cdd:cd15206   165 WYVFLDLMLLVIPGLVMSVAYGLI-------------------SWTLLEAKK--RVIRMLFVIVVEFFICWTP 216
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
46-321 3.01e-14

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 72.07  E-value: 3.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  46 VLVLIFAVSLLGN---VCALVLVARRRRRGATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLS 121
Cdd:cd15098     6 VFGLIFCLGVLGNslvITVLARVKPGKRRSTTNVFILNLSIADLFFlLFCVPFQATIYSLPEWVFGAFMCKFVHYFFTVS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 122 GSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPqrlPGADQEISICTLIWPTI 201
Cdd:cd15098    86 MLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDLVH---HWTASNQTFCWENWPEK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 202 PGEISWDVSFVTLNFLVPGLVIVISYSKILqitKASRKRLTVSLAYSESHQIRVSQqdfrlfrTLFLLMVSFFIMWSPII 281
Cdd:cd15098   163 QQKPVYVVCTFVFGYLLPLLLITFCYAKVL---NHLHKKLKNMSKKSERSKKKTAQ-------TVLVVVVVFGISWLPHH 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1835884573 282 ITILLILIQNFKQDLViwpSLFFWVVA--FTFANSALNPILY 321
Cdd:cd15098   233 IIHLWVEFGDFPLTQA---SFVLRITAhcLAYANSCVNPIIY 271
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
46-321 6.19e-14

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 71.33  E-value: 6.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  46 VLVLIFAVSLLGNVCALVLVARRRRRGATA-CLVLNLFCADLLFISAIPLvLAVRWT--EAWLLGPVACHLLFYVMTLSG 122
Cdd:cd15088     6 VFGCICVVGLVGNGIVLYVLVRCSKLRTAPdIFIFNLAVADLLFMLGMPF-LIHQFAidGQWYFGEVMCKIITALDANNQ 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 123 SVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPqrLPGADQeisICTLIWPTIP 202
Cdd:cd15088    85 FTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIY--FPDGTT---FCYVSLPSPD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 203 GEISWDVSFVTLNFLVPGLVIVISYSKILQITKASrkrltvslaYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIII 282
Cdd:cd15088   160 DLYWFTIYHFILGFAVPLVVITVCYILILHRLARG---------VAPGNQSHGSSRTKRVTKMVILIVVVFIVCWLPFHV 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1835884573 283 TILLILIQNFkqdlviwPSLFFWV-----VAFTFANSALNPILY 321
Cdd:cd15088   231 VQLVNLAMNR-------PTLAFEVayflsICLGYANSCLNPFVY 267
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
41-279 8.34e-14

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 70.61  E-value: 8.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  41 AVETTVLVLIFAVSLLGNVCALVLVARRRRR-GATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVM 118
Cdd:cd15979     1 TVRILLYSVIFLLSVFGNMLIIVVLGLNKRLrTVTNSFLLSLALSDLMLaVFCMPFTLIPNLMGTFIFGEVICKAVAYLM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 119 TLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPgADQEISICTLIW 198
Cdd:cd15979    81 GVSVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVG-DRPRGHQCRHAW 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 199 PTIPGEISWDVSFVTLNFLVPGLVIVISYSKIlqitkaSRKRLTVSLAYSeshqirvsqqdfRLFRTLFLLMVSFFIMWS 278
Cdd:cd15979   160 PSAQVRQAWYVLLLLILFFIPGVVMIVAYGLI------SRELYRGLLAKK------------RVIRMLVVIVAMFFLCWL 221

                  .
gi 1835884573 279 P 279
Cdd:cd15979   222 P 222
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
46-321 9.55e-14

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 70.60  E-value: 9.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  46 VLVLIFAVSLLGN-VCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSV 124
Cdd:cd15974     6 IYLLVCAIGLSGNtLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLATQNAISYWPFGSFLCRLVMTVDGVNQFT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 125 TILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPqrlpgadqEISICTLIWPTiPGE 204
Cdd:cd15974    86 SIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIFSDVQP--------DLNTCNISWPE-PVS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 205 IsWDVSFV----TLNFLVPGLVIVISYSKILQITKASRKRLTVSlayseshqiRVSQQDFRLFRTLFLLMVSFFIMWSPI 280
Cdd:cd15974   157 V-WSTAFIiytaVLGFFGPLLVICLCYLLIVIKVKSSGLRVGST---------KRRKSERKVTRMVVIIVVVFVFCWLPF 226
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1835884573 281 IITILLILIQNFKQDLVIwPSLFFWVVAFTFANSALNPILY 321
Cdd:cd15974   227 YMLNIVNLIVILPEEPAF-VGVYFFVVVLSYANSCANPILY 266
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
74-322 1.78e-13

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 70.02  E-value: 1.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLFIS-AIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGR 152
Cdd:cd15096    35 TNILILNLAVADLLFVVfCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVYTLVLMSLDRYLAVVHPITSMSIRTE 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 153 RARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGAdqEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQ 232
Cdd:cd15096   115 RNTLIAIVGIWIVILVANIPVLFLHGVVSYGFSSE--AYSYCTFLTEVGTAAQTFFTSFFLFSYLIPLTLICVLYMLMLR 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 233 itkasrkrltvSLAYSESHQIRVSQQDF----RLFRTLFLLMVSFFIMWSPIIITIlliliqnFKQDLVIWPSLFFWVVA 308
Cdd:cd15096   193 -----------RLRRQKSPGGRRSAESQrgkrRVTRLVVVVVVVFAICWLPIHIIL-------LLKYYGVLPETVLYVVI 254
                         250       260
                  ....*....|....*....|
gi 1835884573 309 ------FTFANSALNPILYN 322
Cdd:cd15096   255 qilsncLAYGNSCVNPILYA 274
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
46-321 2.14e-13

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 69.45  E-value: 2.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  46 VLVLIFAVSLLGN-VCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSV 124
Cdd:cd15972     6 VYLVVCVVGLGGNtLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNALSYWPFGSFMCRLVMTVDAINQFT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 125 TILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLcVFFRVVPqrlpgadQEISICTLIWPTiPGE 204
Cdd:cd15972    86 SIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPV-VIFSGVP-------GGMGTCHIAWPE-PAQ 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 205 IsWDVSFV----TLNFLVPGLVIVISYSKILQITKASRKRLTVSLAYSESHQIRVSqqdfrlfRTLFLLMVSFFIMWSPI 280
Cdd:cd15972   157 V-WRAGFIiytaTLGFFCPLLVICLCYLLIVVKVRSSGRRVRATSTKRRGSERKVT-------RMVVIVVAAFVLCWLPF 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1835884573 281 IITILLILIQNFKQDLVIWpSLFFWVVAFTFANSALNPILY 321
Cdd:cd15972   229 YALNIVNLVCPLPEEPSLF-GLYFFVVVLSYANSCANPIIY 268
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
42-334 2.23e-13

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 69.76  E-value: 2.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  42 VETTVLVLIFAVSLLGNVCALVLVARRRRR-GATACLVLNLFCADLLFI-SAIPLVLAVRWTEAWLLGPVACHLLFYVMT 119
Cdd:cd14977     2 VIMSLSLVIFAVGIIGNLMVLCIVCTNYYMrSVPNILIASLALGDLLLLlLCVPLNAYNLLTKDWLFGDVMCKLVPFIQV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 120 LSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVpQRLPGADQEISIC----- 194
Cdd:cd14977    82 TSLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTVA-RESSLDNSSLTVCimkps 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 195 TLIWPTIPGEISWdvSFVTLNFLVPGLVIVISYSKIlqitkaSRKRLTVSLAYSESHQIRVsQQDFRLFRTLFLLMVSFF 274
Cdd:cd14977   161 TPFAETYPKARSW--WLFGCYFCLPLAFTAVCYLLM------ARTLIRAAKEYTRGTKKHM-KQRRQLAKTVLCLVLVFA 231
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1835884573 275 IMWSPIIITILLILIqNFKQDLVIwPSLFFWVVAF-----TFANSALNPILYnMTLCRnEWKKIF 334
Cdd:cd14977   232 FCWLPEHISNILRAT-LYNEVLID-TRSTLDILDLigqflSFFNSCVNPIAL-YLLSE-PFRRAF 292
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
74-321 4.65e-13

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 68.69  E-value: 4.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLFIS-AIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIV-HLQRGVrgpG 151
Cdd:cd15399    35 TNFFIANLAVADLMVNTlCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAVHVSTVTLTVIALDRHRCIVyHLESKI---S 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 152 RRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGaDQEISICTLIWP--TIPGEISWDVSFVTLNFLVPGLVIVISYSK 229
Cdd:cd15399   112 KKISFLIIGLTWAASALLASPLAIFREYSVIEISP-DFKIQACSEKWPngTLNDGTIYSVSMLLIQYVLPLAIISYAYIR 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 230 ILqitkaSRKRLTVSLAYSESHQIRVSQQDFRLfrtLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLF--FWVV 307
Cdd:cd15399   191 IW-----TKLKNHVSPGGGNDHYHQRRRKTTKM---LVCVVVVFAVSWLPFHAFQLASDIDSKVLDLKEYKLIYtiFHVI 262
                         250
                  ....*....|....*.
gi 1835884573 308 AF--TFAnsalNPILY 321
Cdd:cd15399   263 AMcsTFA----NPLLY 274
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
77-324 5.95e-13

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 68.42  E-value: 5.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADL-----LFISAIP-LVLAVRW---TEAWLLGPvACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGV 147
Cdd:cd14980    39 LIINLAIADFlmgiyLLIIAIAdQYYRGRYaqySEEWLRSP-PCLLACFLVSLSSLMSVLMMLLITLDRYICIVYPFSNK 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 148 RGPGRRARaVLLALIWGYSAV-AALPLCV-FFRVVPQRLPGADqeiSICTLIWPTIPGEISWDVSFVTLNFLVpGLVIVI 225
Cdd:cd14980   118 RLSYKSAK-IILILGWLFSIIfAAIPILYsINQPGDNRLYGYS---SICMPSNVSNPYYRGWLIAYLLLTFIA-WIIICI 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 226 SYSKILQITKASRKRLTVSLayseshqirvSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPslffW 305
Cdd:cd14980   193 LYILIFISVRKSRKSARRSS----------SKRDKRIAIRLALILITDLICWLPYYIVIFSGLLTSTEIDIHVLQ----F 258
                         250       260
                  ....*....|....*....|
gi 1835884573 306 VVAFTFA-NSALNPILYNMT 324
Cdd:cd14980   259 IAILALPlNSAINPYLYTLT 278
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
44-323 6.58e-13

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 68.29  E-value: 6.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVL-NLFCADLLFISAIPLVLAVRW-TEAWLLGPVACHLLFYVMTLS 121
Cdd:cd15928     4 TAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLsSLAVSDLLIFLVLPLDLYRLWrYRPWRFGDLLCRLMYFFSETC 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 122 GSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVvpQRLPGADQEISICTLIWPTI 201
Cdd:cd15928    84 TYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGV--EHIQGQQTPRGFECTVVNVS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 202 PGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTVSLAYseshqiRVSQQDFRLFRTLFLLMVSFFIMWSPII 281
Cdd:cd15928   162 SGLLSVMLWVSTSFFFVPMVCLSLLYGLIGRALWDRRQRSRTAGAS------RRDNNHRQTVRMLAVIVLAFVLCWLPFH 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1835884573 282 ITILLILIQNFKQDLVIWPSLFFWVVAFT--FANSALNPILYNM 323
Cdd:cd15928   236 VGRVIFNHSRASTKHLHYVSQYFNLVSFVlfYLSAAINPILYNL 279
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
49-321 8.28e-13

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 68.01  E-value: 8.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  49 LIFAVSLLGN-VCALVLVARRRRRGATACLVLNLFCADLLFISAIPLvLAVRWTEAWLLGPVACHLLFYVMTLSGSVTIL 127
Cdd:cd14984     9 LVFLLGLVGNsLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPF-WAVYAADGWVFGSFLCKLVSALYTINFYSGIL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 128 TLAAVSLERMVCIVHLQRGVRgPGRRARAVLLAL-IWGYSAVAALPLCVFFRVVPQrlpgadQEISICTLIWPTIPGEIS 206
Cdd:cd14984    88 FLACISIDRYLAIVHAVSALR-ARTLLHGKLTCLgVWALALLLSLPEFIFSQVSEE------NGSSICSYDYPEDTATTW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 207 WDVSFVTLN---FLVPGLVIVISYSKILQItkasrkrltvsLAYSESHQIRvsqqdfRLFRTLFLLMVSFFIMWSPIIIT 283
Cdd:cd14984   161 KTLLRLLQNilgFLLPLLVMLFCYSRIIRT-----------LLRARNHKKH------RALRVIFAVVVVFFLCWLPYNIV 223
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1835884573 284 ILLILIQNFKqdlVIWPSLFF---------WVVAFTFANSALNPILY 321
Cdd:cd14984   224 LLLDTLQLLG---IISRSCELsksldyalqVTESLAFSHCCLNPVLY 267
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
45-321 9.07e-13

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 67.69  E-value: 9.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGNVCALVLVARRR-RRGATACLVLNLFCADLLFISA-IPLVLAVRWTEAWLLGPVACHLLFYVMTLSG 122
Cdd:cd15001     4 IVYVITFVLGLIGNSLVIFVVARFRrMRSVTNVFLASLATADLLLLVFcVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 123 SVTILTLAAVSLERMVCIVH--LQRGVRGPGRRARAVLlaLIWGYSAVAALPlcVFFRVVPQRLPGAD-QEISICTLIWP 199
Cdd:cd15001    84 ICSVLTLTAISIERYYVILHpmKAKSFCTIGRARKVAL--LIWILSAILASP--VLFGQGLVRYESENgVTVYHCQKAWP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 200 TIPGEISWDVSFVTLNFLVPGLVIVISYskilqitkASRKRLTVslayseshqirvsqqdfrlFRTLFLLMVSFFIMWSP 279
Cdd:cd15001   160 STLYSRLYVVYLAIVIFFIPLIVMTFAY--------ARDTRKQV-------------------IKMLISVVVLFAVCWGP 212
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1835884573 280 IIITILLILIQNFkqDLVIWPSLFFWVVAF---TFANSALNPILY 321
Cdd:cd15001   213 LLIDNLLVSFDVI--STLHTQALKYMRIAFhllSYANSCINPIIY 255
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
74-321 1.78e-12

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 66.79  E-value: 1.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRR 153
Cdd:cd15971    35 TNIYILNLAIADELFMLGLPFLAIQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPR 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 154 ARAVLLALIWGYSAVAALPLCVFFRVVPQrlpgadQEISICTLIWPTIPGeiSWDVSFV----TLNFLVPGLVIVISYSK 229
Cdd:cd15971   115 TAKMINMAVWGVSLLVILPIMIYAGVQTK------HGRSSCTIIWPGESS--AWYTGFIiytfILGFFVPLTIICLCYLF 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 230 ILQITKASRKRLTVSlayseshqiRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIwPSLFFWVVAF 309
Cdd:cd15971   187 IIIKVKSSGIRVGSS---------KRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVSSVSVSISPTPGL-KGMFDFVVVL 256
                         250
                  ....*....|..
gi 1835884573 310 TFANSALNPILY 321
Cdd:cd15971   257 SYANSCANPILY 268
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
48-322 1.79e-12

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 67.03  E-value: 1.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  48 VLIFAVSLLGN--VCALVLVARRRRRgATACLVLNLFCADLLFI-SAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSV 124
Cdd:cd15208     8 ILVFIVGLVGNvlVCFAVWRNHHMRT-VTNYFIVNLSLADFLVIiICLPATLLVDVTETWFFGQVLCKIIPYLQTVSVSV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 125 TILTLAAVSLERMVCIVHLQRgVRGPGRRARAVLLaLIWGYSAVAALPLCVF---FRVVPQRlpgadQEISICTLIWPTI 201
Cdd:cd15208    87 SVLTLSCIALDRWYAICHPLM-FKSTAKRARVSIL-IIWIVSLLIMIPQAIVmecSRVVPLA-----NKTILLTVCDERW 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 202 PGEIS---WDVSFVTLNFLVPGLVIVISYSKIL------QITKAS---RKRLTVSLAYSESHQIRVSQQDFRLFRTLFLL 269
Cdd:cd15208   160 SDSIYqkvYHICFFLVTYLLPLCLMILAYFQIFrklwcrQIPGTSsvvQRKWNKPRKSAVAAEEKQLRSRRKTAKMLIVV 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1835884573 270 MVSFFIMWSPIIIT----ILLILIQNFKQDLVIWPSLFFWVVaftFANSALNPILYN 322
Cdd:cd15208   240 VIMFAICYLPVHLLnilrYVFGLFTVDRETIYAWFLFSHWLV---YANSAINPIIYN 293
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
74-321 1.92e-12

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 67.05  E-value: 1.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRgvRGPGR 152
Cdd:cd15393    35 TNIFIANLAVADIIIgLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVNVSVFTLTVIAVDRYRAVIHPLK--ARCSK 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 153 RARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKI-- 230
Cdd:cd15393   113 KSAKIIILIIWILALLVALPVALALRVEELTDKTNNGVKPFCLPVGPSDDWWKIYNLYLVCVQYFVPLVIICYAYTRIav 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 231 -LQITKASRKRLTVSLAysesHQIRVSQqdfRLFRTLFLLMVSFFIMWSPI----IITILLILIQNFKQDLVIWpslfFW 305
Cdd:cd15393   193 kIWGTKAPGNAQDVRDD----EILKNKK---KVIKMLIIVVALFALCWLPLqtynLLNEIKPEINKYKYINIIW----FC 261
                         250
                  ....*....|....*.
gi 1835884573 306 VVAFTFANSALNPILY 321
Cdd:cd15393   262 SHWLAMSNSCYNPFIY 277
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
74-279 2.47e-12

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 66.69  E-value: 2.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLFISA-IPLVLAVRWTE-AWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRgvRGPG 151
Cdd:cd15394    35 TNFLIGNLAFSDMLMCATcVPLTLAYAFEPrGWVFGRFMCYFVFLMQPVTVYVSVFTLTAIAVDRYYVTVYPLR--RRIS 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 152 RRARAVLLALIWGYSAVAALPLCVFfrvvPQRLPGADQEISICTLIWPTIPGE-ISWDVSFVTLNFLVPGLVIVISYski 230
Cdd:cd15394   113 RRTCAYIVAAIWLLSCGLALPAAAH----TYYVEFKGLDFSICEEFWFGQEKQrLAYACSTLLITYVLPLLAISLSY--- 185
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1835884573 231 LQITKASRKRLTVSLAYsESHQIRVSQQDFRLFRTLFLLMVSFFIMWSP 279
Cdd:cd15394   186 LRISVKLRNRVVPGSMT-QSQAEWDRARRRKTFRLLVVVVVAFAICWLP 233
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
44-321 3.02e-12

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 66.13  E-value: 3.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCALV-LVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSG 122
Cdd:cd15089     4 TALYSVVCVVGLLGNVLVMYgIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNM 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 123 SVTILTLAAVSLERMVCIVHLQRGV--RGPGRrARAVLLAlIWGYSAVAALPLCVFfRVVPQRLPGAdqeiSICTLIWPT 200
Cdd:cd15089    84 FTSIFTLTMMSVDRYIAVCHPVKALdfRTPAK-AKLINIC-IWVLSSGVGVPIMVM-AVTKTPRDGA----VVCMLQFPS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 201 IPgeISWD----VSFVTLNFLVPGLVIVISYSKILQITKASRkrlTVSLAYSESHQIRvsqqdfRLFRTLFLLMVSFFIM 276
Cdd:cd15089   157 PS--WYWDtvtkICVFIFAFVVPILVITVCYGLMILRLRSVR---LLSGSKEKDRNLR------RITRMVLVVVAAFIIC 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1835884573 277 WSPIIITILLILIQNF-KQDLVIWPSLFFwVVAFTFANSALNPILY 321
Cdd:cd15089   226 WTPIHIFVIVWTLVDIdRRNPLVVAALHL-CIALGYANSSLNPVLY 270
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
79-321 5.78e-12

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 65.56  E-value: 5.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  79 LNLFCADLLFISAIPLvLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVL 158
Cdd:cd15179    40 LHLSVADLLFVLTLPF-WAVDAAANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVV 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 159 LALIWGYSAVAALPLCVFFRVvpqrlpGADQEISICTLIWPTIPGEIsWDVSF----VTLNFLVPGLVIVISYSKILQit 234
Cdd:cd15179   119 YVGVWLPALLLTVPDLVFAKV------SELDDRYICDRIYPEDTFEL-WVVAFrfqhILVGLVLPGLVILTCYCIIIS-- 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 235 kasrkrltvSLAYSESHQIRvsqqdfRLFRTLFLLMVSFFIMWSPIIITILL---ILIQNFKQDLVIWPSLFFWVV---A 308
Cdd:cd15179   190 ---------KLSHSKGHQKR------KALKTTVILILAFFACWLPYYIGISIdtfMLLEIIKQSCEMEQTVHKWISiteA 254
                         250
                  ....*....|...
gi 1835884573 309 FTFANSALNPILY 321
Cdd:cd15179   255 LAFFHCCLNPILY 267
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
74-321 9.61e-12

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 64.82  E-value: 9.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIV--HLQRGVRGPg 151
Cdd:cd15122    37 TCILILNLAVADGAVLLLTPFFITFLTRKTWPFGQAVCKAVYYLCCLSMYASIFIIGLMSLDRCLAVTrpYLAQSLRKK- 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 152 RRARAVLLAlIWGYSAVAALPlCVFFRVVPQRLPGADqeiSICTLIWPTiPGEISWDVSFVTL-NFLVPGLVIVISYSKI 230
Cdd:cd15122   116 ALVRKILLA-IWLLALLLALP-AFVYRHVWKDEGMND---RICEPCHAS-RGHAIFHYTFETLvAFVLPFGVILFSYSVI 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 231 LQITKASRKRltvslayseshqirvsqQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLV------IWPSLFF 304
Cdd:cd15122   190 LVRLKGARFR-----------------RRARVEKLIAAIVVAFALLWVPYHVVNLLQVVANLAPGEVleklggAAKAARA 252
                         250
                  ....*....|....*..
gi 1835884573 305 WVVAFTFANSALNPILY 321
Cdd:cd15122   253 GATALAFFSSSVNPLLY 269
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
48-322 1.32e-11

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 64.42  E-value: 1.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  48 VLIFAVSLLGN-VCALVLVARRRRRGATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVT 125
Cdd:cd15205     8 VLIFVLALFGNsLVIYVVTRKRAMRTATNIFICSLALSDLLItFFCIPFTLLQNISSNWLGGAFMCKMVPFVQSTAVVTS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 126 ILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEI 205
Cdd:cd15205    88 ILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQQLEVKYDFLYEKRHVCCLERWYSPTQQK 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 206 SWDVSFVTLNFLVPGLVIVISYSKI---LQItkasRKRLTVSLAYSESHQI---RVSQQDFRLFRTLFLLMVSFFIMWSP 279
Cdd:cd15205   168 IYTTFILVILFLLPLTTMLFLYSRIgyeLWI----KKRVGDASVLQTIHGIemsKISRKKKRAVKMMVTVVLLFAVCWAP 243
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1835884573 280 IIITILLILIQNF--KQDLVIWPSLFFWVVAFTFANSALNPILYN 322
Cdd:cd15205   244 FHVVHMMIEYSNLenKYDGVTIKLIFAIVQLIGFSNSFNNPIVYA 288
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
78-321 1.40e-11

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 64.42  E-value: 1.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  78 VLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAV 157
Cdd:cd15094    39 ILNLAVADECFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKV 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 158 LLALIWGYSAVAALPLCVFFRVVPqrlpgaDQEISICTLIWP---TIPGEISWDVSFVTLNFLVPGLVIVISYSKILqit 234
Cdd:cd15094   119 VCATTWSISFLVMLPIILYASTVP------DSGRYSCTIVWPdssAVNGQKAFTLYTFLLGFAIPLLLISVFYTLVI--- 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 235 kasRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVsffIMWSPIIITILLILIQNFKQDLVIWPSLFFWVV-AFTFAN 313
Cdd:cd15094   190 ---LRLRTVGPKNKSKEKRRSHRKVTRLVLTVISVYI---ICWLPYWAFQVHLIFLPPGTDMPKWEILMFLLLtVLSYAN 263

                  ....*...
gi 1835884573 314 SALNPILY 321
Cdd:cd15094   264 SMVNPLLY 271
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
73-321 1.71e-11

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 63.82  E-value: 1.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  73 ATACLVLNLFCADLLFISAI-PLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPG 151
Cdd:cd15210    34 RTNAFIINLSISDLLFCAFNlPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSLLTLVLITLNRYILIAHPSLYPRIYT 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 152 RRARAVLLALIW--GYSAVAALPLCVFFRVvpqrlpGADQEISICTlIWPTIPGEiSWDVSFVTLNFLVPGLVIVISYSK 229
Cdd:cd15210   114 RRGLALMIAGTWifSFGSFLPLWLGIWGRF------GLDPKVCSCS-ILRDKKGR-SPKTFLFVFGFVLPCLVIIICYAR 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 230 ilqitkasrkrltvslayseshqirvsQQDFRLFRTLFLLMVSFFIMWSPIIITilliliqNFKQDLVIWPSLFFWVVAF 309
Cdd:cd15210   186 ---------------------------REDRRLTRMMLVIFLCFLVCYLPITLV-------NVFDDEVAPPVLHIIAYVL 231
                         250
                  ....*....|..
gi 1835884573 310 TFANSALNPILY 321
Cdd:cd15210   232 IWLSSCINPIIY 243
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
44-321 2.51e-11

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 63.43  E-value: 2.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGN-VCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSG 122
Cdd:cd15091     4 TAVYSVVFVVGLVGNsLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNM 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 123 SVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQrlpgADQEISICTLIWPTiP 202
Cdd:cd15091    84 FTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVR----EDVDSTECSLQFPD-D 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 203 GEISWD----VSFVTLNFLVPGLVIVISYSKILQITKASRkrlTVSLAYSESHQIRvsqqdfRLFRTLFLLMVSFFIMWS 278
Cdd:cd15091   159 DYSWWDtfmkICVFIFAFVIPVLIIIVCYTLMILRLKSVR---LLSGSREKDRNLR------RITRLVLVVVAVFVVCWT 229
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1835884573 279 PIIITILLILIQNFKQDLVIWPSLFFwVVAFTFANSALNPILY 321
Cdd:cd15091   230 PIHIFILVEALGSVSHSTAAVSSYYF-CIALGYTNSSLNPILY 271
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
44-324 2.54e-11

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 63.46  E-value: 2.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCALVLVARRR-RRGATACLVLNLFCADLLF-ISAIPLVLAVRWT-EAWLLGPVACHLLFYVMTL 120
Cdd:cd14997     4 SVVYGVIFVVGVLGNVLVGIVVWKNKdMRTPTNIFLVNLSVADLLVlLVCMPVALVETWArEPWLLGEFMCKLVPFVELT 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 121 SGSVTILTLAAVSLERMVCIVH-LQRGVRGPGRRArAVLLALIWGYSAVAALPlcVFFRVVPQRLPGADQE-ISICTliw 198
Cdd:cd14997    84 VAHASVLTILAISFERYYAICHpLQAKYVCTKRRA-LVIIALIWLLALLTSSP--VLFITEFKEEDFNDGTpVAVCR--- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 199 ptIPGEISWDVSFVT----LNFLVPGLVIVISYSKIlqitkaSRKRLTVSLAYS---ESHQIRVSQQDFRLFRTLFLLMV 271
Cdd:cd14997   158 --TPADTFWKVAYILstivVFFVVPLAILSGLYSVI------CRRLVGHPALESrraDAANRHTLRSRRQVVYMLITVVV 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1835884573 272 SFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFT----FANSALNPILYNMT 324
Cdd:cd14997   230 LFFVCLLPFRVVTLWIIFAPDEDLQALGLEGYLNLLVFCrvmvYLNSALNPILYNLM 286
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
44-332 2.71e-11

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 63.61  E-value: 2.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCALVLVARR-RRRGATACLVLNLFCADLLfISAIPLVLAVRW--TEAWLLGPVACHLLFYVMTL 120
Cdd:cd15384     4 IVVLAVMFVISFIGNLLTIIQIYRLrRSRRTIYSLLLHLAIADLL-VTFFCIPSEAIWayTVAWLAGNTMCKLVKYLQVF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 121 SGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLAliWGYSAVAALPLCVFFRV-VPQRLPGADQEIS--ICTLI 197
Cdd:cd15384    83 GLYLSTYITVLISLDRCVAILYPMKRNQAPERVRRMVTVA--WILSPIFSIPQAVIFHVeRGPFVEDFHQCVTygFYTAE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 198 WPtipgEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTVSLAYSESHQirvsQQDFRLF--------RTLFLL 269
Cdd:cd15384   161 WQ----EQLYNMLSLVFMFPIPLVIMVTCYVLIFITLSKSSRDFQGLEIYTRNRG----PNRQRLFhkakvkslRMSAVI 232
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1835884573 270 MVSFFIMWSPIIITILLILiqnFKQDLVIWPSLFFWVVAFTFANSALNPILYNM-TLCRNEWKK 332
Cdd:cd15384   233 VTAFILCWTPYYVIMIWFL---FFNPYPLNDILFDVIFFFGMSNSCVNPLIYGAfHITKKKGGK 293
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
41-321 3.06e-11

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 63.35  E-value: 3.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  41 AVETTVLVLIFAVSLLGNVCALVLVAR-RRRRGATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVM 118
Cdd:cd15978     1 TVRILLYSLIFLLSVLGNSLIIAVLIRnKRMRTVTNIFLLSLAVSDLMLcLFCMPFTLIPNLLKDFIFGSAVCKTATYFM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 119 TLSGSVTILTLAAVSLERMVCIVH-LQRGVRGPGRRARAVLLAlIWGYSAVAALPLCVFFRVVPqRLPGADQEISICTLI 197
Cdd:cd15978    81 GISVSVSTFNLVAISLERYSAICKpLKSRVWQTKSHALKVIAA-TWCLSFTIMLPYPIYSNLVP-FTRINNSTGNMCRLL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 198 WPTIPGEISWDVSFVTLNFLVPGLVIVISYSKIlqitkasrkrltvSLAYSESHQIRVSQQdfRLFRTLFLLMVSFFIMW 277
Cdd:cd15978   159 WPNDVTQQSWYIFLLLILFLIPGIVMMTAYGLI-------------SLELYRGIKFLMAKK--RVIRMLIVIVILFFLCW 223
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1835884573 278 SPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILY 321
Cdd:cd15978   224 TPIFSANAWRAFDTRSADRLLSGAPISFIHLLSYTSACVNPIIY 267
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
77-321 3.11e-11

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 63.49  E-value: 3.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLFiSAI---PLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRR 153
Cdd:cd15337    38 FIINLAISDFGF-SAVngfPLKTISSFNKKWIWGKVACELYGFAGGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFK 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 154 ARAVLLALIWGYSAVAAL-PLCVFFRVVPQRLpgadqeISICTLIW-PTIPGEISWDVSFVTLNFLVPGLVIVISYSKIL 231
Cdd:cd15337   117 RAFIMIIIIWLWSLLWSIpPFFGWGRYVPEGF------QTSCTFDYlSRDLNNRLFILGLFIFGFLCPLLIIIFCYVNII 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 232 QITKASRKRLTVSLAYSESHQIRVSQ----QDFRLFRTLFLLMVSFFIMWSPIIITILLILiqnFKQDLVIWPSLFFWVV 307
Cdd:cd15337   191 RAVRNHEKEMTQTAKSGMGKDTEKNDarkkAEIRIAKVAIILISLFLLSWTPYAVVALLGQ---FGPAYWITPYVSELPV 267
                         250
                  ....*....|....
gi 1835884573 308 AFTFANSALNPILY 321
Cdd:cd15337   268 MFAKASAIYNPIIY 281
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
74-321 3.66e-11

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 63.08  E-value: 3.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLfISAI--PLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVH-LQRgvRGP 150
Cdd:cd15390    35 TNYFLVNLAVADLL-ISAFntVFNFTYLLYNDWPFGLFYCKFSNFVAITTVAASVFTLMAISIDRYIAIVHpLRP--RLS 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 151 GRRARAVlLALIWGYSAVAALPLCVFFRVVPQRLPGaDQEISICTLIWPTIPG---EISWDVSFVTLNFLVPGLVIVISY 227
Cdd:cd15390   112 RRTTKIA-IAVIWLASFLLALPQLLYSTTETYYYYT-GSERTVCFIAWPDGPNslqDFVYNIVLFVVTYFLPLIIMAVAY 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 228 SKILQITKASRkrltvSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPiiiTILLILIQNFKQDLVIWPS------ 301
Cdd:cd15390   190 TRVGVELWGSK-----TIGENTPRQLESVRAKRKVVKMMIVVVVIFAICWLP---YHLYFILTYLYPDINSWKYiqqiyl 261
                         250       260
                  ....*....|....*....|
gi 1835884573 302 LFFWVvafTFANSALNPILY 321
Cdd:cd15390   262 AIYWL---AMSNSMYNPIIY 278
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
77-334 4.51e-11

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 62.36  E-value: 4.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLFISAI-PLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRAR 155
Cdd:cd15059    38 FLVSLAVADILVGLLImPFSLVNELMGYWYFGSVWCEIWLALDVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 156 AVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQeisiCTLiwPTIPGEIswdVSFVTLNFLVPGLVIVISYSKILQITK 235
Cdd:cd15059   118 KAMIAAVWIISAVISLPPLFGWKDEQPWHGAEPQ----CEL--SDDPGYV---LFSSIGSFYIPLLIMIIVYARIYRAAK 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 236 ASRKRLTVSLAyseshqirvsqqdfrlfrtlfLLMVSFFIMWSPIIITILLILiqnFKQDLVIWPSLFFWVVAFTFANSA 315
Cdd:cd15059   189 RKERRFTLVLG---------------------VVMGAFVLCWLPFFFTYPLVV---VCKTCGVPELLFKFFFWLGYCNSA 244
                         250
                  ....*....|....*....
gi 1835884573 316 LNPILYnmTLCRNEWKKIF 334
Cdd:cd15059   245 LNPVIY--TIFNKDFRRAF 261
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
46-323 4.60e-11

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 62.87  E-value: 4.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  46 VLVLIFAVSLLGNVCALVLVAR-RRRRGATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGS 123
Cdd:cd15209     6 VLIVTIVVDVLGNLLVILSVLRnKKLRNAGNIFVVSLSVADLVVaIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLSVI 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 124 VTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPlcVFFRVVPQRlpgaDQEISICTLIWPTIPg 203
Cdd:cd15209    86 GSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLP--NFFIGSLQY----DPRIYSCTFAQTVST- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 204 eiSWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLtvslaySESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIIT 283
Cdd:cd15209   159 --VYTITVVVIHFLLPLLIVSFCYLRIWVLVLQVRQRV------KPDQRPKLKPADVRNFLTMFVVFVLFAVCWAPLNFI 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1835884573 284 ILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNM 323
Cdd:cd15209   231 GLAVAINPKEMAPKIPEWLFVASYFMAYFNSCLNAIIYGL 270
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
42-321 4.75e-11

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 62.78  E-value: 4.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  42 VETTVLVLIFAVSLLGNVCALVLVARRRRRGATA-CLVLNLFCADLlFISAIPLVLAVRW--TEAWLLGPVACHLLFY-- 116
Cdd:cd14986     2 SRVAVLGVLFVFTLVGNGLVILVLRRKRKKRSRVnIFILNLAIADL-VVAFFTVLTQIIWeaTGEWVAGDVLCRIVKYlq 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 117 VMTLSGSVTILTlaAVSLERMVCIVHLQRGVRGPGRRARAVLLAliWGYSAVAALPLCVFFrvVPQRLPGAdqeISICTL 196
Cdd:cd14986    81 VVGLFASTYILV--SMSLDRYQAIVKPMSSLKPRKRARLMIVVA--WVLSFLFSIPQLVIF--VERELGDG---VHQCWS 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 197 IWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQ-ITKASRKRLTVSLAYSESH--QIRVSQQDFRLF-----RTL-- 266
Cdd:cd14986   152 SFYTPWQRKVYITWLATYVFVIPLIILSYCYGRILRtIWIRSRQKTDRPIAPTAMScrSVSCVSSRVSLIsrakiKTIkm 231
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1835884573 267 -FLLMVSFFIMWSPIIITILLILIQNFKQDLVIwpslfFWVVAFTFA--NSALNPILY 321
Cdd:cd14986   232 tLVIILAFILCWTPYFIVQLLDVYAGMQQLEND-----AYVVSETLAslNSALNPLIY 284
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
44-279 5.35e-11

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 62.38  E-value: 5.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGN-VCALVLVARRRRRGATACLVLNLFCADLLFISAIPlVLAVRWTEAWLLGPVACHLLFYVMTLSG 122
Cdd:cd15182     4 PVFYYLVFLLSLLGNgLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLP-FWASYHSSGWIFGEILCKAVTSIFYIGF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 123 SVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPqrlpgADQEISICTLIWPTip 202
Cdd:cd15182    83 YSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVMK-----SDEDGSLCEYSSIK-- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 203 gEISWDVSFVTLNFLVPGLVIVISYSKILQI---TKASRKRLTVSLayseshqirvsqqdfrlfrtLFLLMVSFFIMWSP 279
Cdd:cd15182   156 -WKLGYYYQQNLFFLIPLGIIVYCYVRILQTlmrTRTMRKHRTVKL--------------------IFVIVLVFFLSWAP 214
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
73-321 5.77e-11

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 62.57  E-value: 5.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  73 ATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGR 152
Cdd:cd15973    34 ATNIYILNLAIADELFMLSVPFLAASAALQHWPFGSAMCRTVLSVDGINMFTSVFCLTVLSVDRYIAVVHPLRAARYRRP 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 153 RARAVLLALIWGYSAVAALPLCVFFRVVPQrlpgaDQEISICTLIWPtipgEISWDVSFVT----LNFLVPGLVIVISYs 228
Cdd:cd15973   114 TVAKMINICVWILSLLVISPIIIFADTATR-----KGQAVACNLIWP----HPAWSAAFVIytflLGFLLPVLAIGLCY- 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 229 kILQITKASRKRLTVSLaysesHQIRVSQQdfRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFfwvva 308
Cdd:cd15973   184 -ILIIGKMRAVALKAGW-----QQRRKSEK--KITRMVLMVVTVFVICWMPFYVVQLLNLFLPRLDATVNHASLI----- 250
                         250
                  ....*....|...
gi 1835884573 309 FTFANSALNPILY 321
Cdd:cd15973   251 LSYANSCANPILY 263
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
45-323 6.17e-11

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 62.71  E-value: 6.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGNVCALVLVARRRRRGA--TACLVLNLFCADLL--FIsAIPLVLAVRWTEAWLLGPVACHLLFYVMTL 120
Cdd:cd15382     5 IVYSVLFLIAAVGNLTVLLILLRNRRRKRsrVNILLMHLAIADLLvtFI-MMPLEIGWAATVAWLAGDFLCRLMLFFRAF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 121 SGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLAliWGYSAVAALPLCVFFRVVPQ-RLPGADQEISICTLiwP 199
Cdd:cd15382    84 GLYLSSFVLVCISLDRYFAILKPLRLSDARRRGRIMLAVA--WVISFLCSIPQSFIFHVESHpCVTWFSQCVTFNFF--P 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 200 TIPGEISWDVSFVTLNFLVPGLVIVISYSKIL-QITKASRKRLTVSLAYSESHQIRVSQQDF------RLFRTLFLLMVS 272
Cdd:cd15382   160 SHDHELAYNIFNMITMYALPLIIIVFCYSLILcEISRKSKEKKEDVSEKSSSVRLRRSSVGLlerarsRTLKMTIVIVLV 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1835884573 273 FFIMWSPIIITILLILIQNFKQDLV---IWPSLFfwvvAFTFANSALNPILYNM 323
Cdd:cd15382   240 FIICWTPYFIMSLWYWFDRESASKVdprIQKGLF----LFAVSNSCMNPIVYGY 289
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
44-323 7.15e-11

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 62.18  E-value: 7.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCALVLVAR-RRRRGATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLS 121
Cdd:cd15400     4 SSVLIFTTVVDILGNLLVIISVFRnRKLRNSGNVFVVSLALADLVVaLYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 122 GSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPlcVFFRVVPQRlpgaDQEISICTLIWPTi 201
Cdd:cd15400    84 VIGSIFNITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTVVAIVP--NFFVGSLEY----DPRIYSCTFVQTA- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 202 pgEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRltvslAYSEShQIRVSQQDFRLFRTLFLLMVSFFIMWSPII 281
Cdd:cd15400   157 --SSSYTIAVVVIHFIVPITVVSFCYLRIWVLVIQVRRK-----VKSES-KPRLKPSDFRNFLTMFVVFVIFAICWAPLN 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1835884573 282 ITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNM 323
Cdd:cd15400   229 LIGLAVAINPQEMAPKVPEWLFVVSYFMAYFNSCLNAIIYGL 270
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
49-321 8.14e-11

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 61.97  E-value: 8.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  49 LIFAVSLLGN--VCALVLVARRRRRgATACLVLNLFCADLLFIS-AIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVT 125
Cdd:cd15389     9 IIIVISLFGNslVCHVIFKNKRMHT-ATNLFIVNLAVSDILITLlNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVYVS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 126 ILTLAAVSLERMVCIVH-LQRGVRgpgRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLpGADQEISICTLIWPTiPGE 204
Cdd:cd15389    88 TLTLTAIALDRHRVILHpLKPRIT---PCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEY-SNERTRSRCLPSFPE-PSD 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 205 ISW---DVSFVTLNFLVPGLVIVISYSKILqitkasrKRL---TVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWS 278
Cdd:cd15389   163 LFWkylDLATFILQYVLPLLIIGVAYTRVA-------KKLwlrNAIGDVTTEQYVAQRRKKKKTIKMLMLVVLLFAICWL 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1835884573 279 PIIITILLILIQNFKQDlviwPSLFFWVVAFTFANSALNPILY 321
Cdd:cd15389   236 PLNCYHVLLSSHPIRSN----SALFFAFHWLAMSSTCYNPFIY 274
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
44-334 9.98e-11

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 61.68  E-value: 9.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCALVLVAR-RRRRGATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLS 121
Cdd:cd14992     4 GVALVVIILVSVVGNFIVIAALARhKNLRGATNYFIASLAISDLLMaLFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 122 GSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTliWPTI 201
Cdd:cd14992    84 VYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVKNQEKIFCCQ--IPPV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 202 PGEISWDVSFV---TLNFLVPGLVIVISYSKIlQITKASRKRLTVSLAYSESHQIRVSQqdfRLFRTLFLLMVSFFIMWS 278
Cdd:cd14992   162 DNKTYEKVYFLlifVVIFVLPLIVMTLAYARI-SRELWFRKVPGFSIKEVERKRLKCKR---RVIKMLVCVVVLFVICWL 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1835884573 279 PiiiTILLILIQNFKQDLVIWP---SLFFWVVAFTFANSALNPILYnmTLCRNEWKKIF 334
Cdd:cd14992   238 P---FHLFFLLRDFFPLIMKEKhtlQVYYFLHWIAMSNSMYNPIIY--VTLNNNFRKNF 291
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
44-323 1.02e-10

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 61.78  E-value: 1.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCALVLVAR-RRRRGATACLVLNLFCADLL-FISAIPLVLAVRWTE-AWLLGPVACHLLFYVMTL 120
Cdd:cd15133     4 CLTYLLIFVVGVVGNVLTCLVIARhKAMRTPTNYYLFSLAVSDLLvLLLGMPLELYELWQNyPFLLGSGGCYFKTFLFET 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 121 SGSVTILTLAAVSLERMVCIVH-LQRGVRGPGRRARAVlLALIWGYSAVAALPLCVF--FRVVPQRLPGAdqeiSICTLI 197
Cdd:cd15133    84 VCLASILNVTALSVERYIAVVHpLAARTCSTRPRVTRV-LGCVWGVSMLCALPNTSLhgIKFLGSGVPAS----AQCTVR 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 198 WPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTVSLAYSESHQIRVSQQDFR---LFRTLFLLMVSFF 274
Cdd:cd15133   159 KPQAIYNMIPQHTGHLFFVLPMAVISVLYLLMALRLARERGLDATGAGSKIGTRTGQLLQHPRTraqVTKMLFILVVVFA 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1835884573 275 IMWSPiiitilliliqnFKQDLVIWPSLFFW------------VVA--FTFANSALNPILYNM 323
Cdd:cd15133   239 ICWAP------------FHIDRLMWSFISDWtdnlhevfqyvhIISgvFFYLSSAVNPILYNL 289
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
80-321 1.51e-10

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 61.31  E-value: 1.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  80 NLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVL 158
Cdd:cd15012    40 NLAVADLCVgIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVT 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 159 LALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLnFLVPGLVIVISYSKIlqitkasr 238
Cdd:cd15012   120 IVTVWLTSAVYNTPYFVFSQTVEILVTQDGQEEEICVLDREMFNSKLYDTINFIVW-YLIPLLIMTVLYSKI-------- 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 239 krltvSLAYSESHQIRVSQQDFRLfrtLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVV-AFTFANSALN 317
Cdd:cd15012   191 -----SIVLWKSSSIEARRKVVRL---LVAVVVSFALCNLPYHARKMWQYWSEPYRCDSNWNALLTPLTfLVLYFNSAVN 262

                  ....
gi 1835884573 318 PILY 321
Cdd:cd15012   263 PLLY 266
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
77-324 2.06e-10

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 60.68  E-value: 2.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADL-----LFISAIPLVL--------AVRWTEAWLlgpvaCHLLFYVMTLSGSVTILTLAAVSLERMVCIVHL 143
Cdd:cd15137    38 LIKNLAIADFlmgvyLLIIASVDLYyrgvyikhDEEWRSSWL-----CTFAGFLATLSSEVSVLILTLITLDRFICIVFP 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 144 QRGVRgPGRRARAVLLALIWGYS-AVAALPLcvffrVVPQRLPGADQEISICTLIWPTIPGEISWDVS---FVTLNFLVp 219
Cdd:cd15137   113 FSGRR-LGLRRAIIVLACIWLIGlLLAVLPL-----LPWDYFGNFYGRSGVCLPLHITDERPAGWEYSvfvFLGLNFLA- 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 220 GLVIVISYSKILQITKASRKRLTvslayseSHQirvSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNfkqdlVIW 299
Cdd:cd15137   186 FVFILLSYIAMFISIRRTRKAAA-------SRK---SKRDMAVAKRFFLIVLTDFLCWIPIIVIGILALSGV-----PIP 250
                         250       260
                  ....*....|....*....|....*.
gi 1835884573 300 PSLFFWVVAFTFA-NSALNPILYNMT 324
Cdd:cd15137   251 GEVYAWVAVFVLPiNSALNPILYTLS 276
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
45-323 2.50e-10

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 60.69  E-value: 2.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGNVCALVLVAR-RRRRGATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSG 122
Cdd:cd15402     5 CILIFTIVVDILGNLLVILSVYRnKKLRNAGNIFVVSLAVADLVVaIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGLSV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 123 SVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAalplcvffrVVPQRLPGA---DQEISICTLiwp 199
Cdd:cd15402    85 IGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAA---------IVPNLFVGSlqyDPRIYSCTF--- 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 200 TIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLtvslaySESHQIRVSQQDFRLFRTLFLLMVSFFIMWSP 279
Cdd:cd15402   153 AQSVSSAYTIAVVFFHFILPIIIVTFCYLRIWILVIQVRRRV------KPDNKPKLKPHDFRNFVTMFVVFVLFAVCWAP 226
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1835884573 280 IIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNM 323
Cdd:cd15402   227 LNFIGLAVAVDPETIVPRIPEWLFVASYYMAYFNSCLNAIIYGL 270
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
49-325 2.81e-10

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 60.59  E-value: 2.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  49 LIFAVSLLGNVCALVLVAR---RRRRGATACLVLNLFCADLLFISAIPLVLAVRWTE-AWLLGPVACHLLFYVMTLSGSV 124
Cdd:cd14976     9 VVFTVGLLGNLLVLYLLKSnkkLRQQSESNKFVFNLALTDLIFVLTLPFWAVEYALDfVWPFGTAMCKVVRYVTKLNMYS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 125 TILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFfrvvpQRLPGADQEISICTLIWPTIPGE 204
Cdd:cd14976    89 SIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIF-----STDTWSSVNHTLCLLRFPKNSSV 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 205 ISW-------DVSFVTLNFLVPGLVIVISYSKILqitkasrkrltvslAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMW 277
Cdd:cd14976   164 TRWynwlgmyQLQKVVLGFFLPLGIITLSYLLLL--------------RFLQRKRGGSKRRKSRVTKSVFIVVLSFFICW 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1835884573 278 SPIIITILLILIQNFkqDLVIWPSLFF--------WVVAFTFANSALNPILYNMTL 325
Cdd:cd14976   230 LPNQALSLWSALIKF--DDVPFSDAFFafqtyafpVAICLAHSNSCLNPVLYCLVR 283
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
73-334 2.92e-10

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 60.05  E-value: 2.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  73 ATACLVLNLFCADLLF-ISAIPLVLAVRWT-EAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGP 150
Cdd:cd15053    34 ATNYFIVSLAVADLLVaILVMPFAVYVEVNgGKWYLGPILCDIYIAMDVMCSTASIFNLCAISIDRYIAVTQPIKYARQK 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 151 GRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPgadqeiSICTL------IWPTIpgeiswdVSFVtlnflVPGLVIV 224
Cdd:cd15053   114 NSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRDP------EECRFynpdfiIYSSI-------SSFY-----IPCIVML 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 225 ISYSKILQITKASRKRLtvslayseshqirvsqqdfrlfRTLFLLMVSFFIMWSP--IIITILLILIQNFKQDLVIWPSL 302
Cdd:cd15053   176 LLYYRIFRALRREKKAT----------------------KTLAIVLGVFLFCWLPffTLNILNAICPKLQNQSCHVGPAL 233
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1835884573 303 FFWVVAFTFANSALNPILYnmTLCRNEWKKIF 334
Cdd:cd15053   234 FSLTTWLGYVNSFLNPIIY--TIFNIEFRKAF 263
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
45-242 3.61e-10

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 60.22  E-value: 3.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGNVCALVLVARRRRRGATAC-LVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGS 123
Cdd:cd15121     5 AILSLAFILGFPGNLFVVWSVLCRMKKRSVTCiLVLNLALADAAVLLTAPFFLHFLSGGGWEFGSVVCKLCHYVCGVSMY 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 124 VTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLpgadqEISICTLIWPTiPG 203
Cdd:cd15121    85 ASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPFYRTVLKKNI-----NMKLCIPYHPS-VG 158
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1835884573 204 EISWDVSFVTL-NFLVPGLVIVISYSKI---LQITKASRKRLT 242
Cdd:cd15121   159 HEAFQYLFETItGFLLPFTAIVTCYSTIgrrLRSARFRRKRRT 201
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
46-323 4.38e-10

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 59.92  E-value: 4.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  46 VLVLIFAVSLLGNVCALVLVAR-RRRRGATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGS 123
Cdd:cd15401     6 VLIFTIVVDVLGNLLVILSVLRnKKLRNAGNIFVVSLSVADLVVaVYPYPLILLAIFHNGWTLGNIHCQISGFLMGLSVI 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 124 VTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPlcVFFRVVPQRlpgaDQEISICTLIWPTipg 203
Cdd:cd15401    86 GSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIVP--NFFVGSLQY----DPRIYSCTFAQTV--- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 204 EISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLtvslaySESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIIT 283
Cdd:cd15401   157 SSSYTITVVVVHFIVPLSIVTFCYLRIWVLVIQVKHRV------RQDSKQKLKANDIRNFLTMFVVFVLFAVCWGPLNFI 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1835884573 284 ILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNM 323
Cdd:cd15401   231 GLAVAINPLKVAPKIPEWLFVLSYFMAYFNSCLNAVIYGV 270
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
44-321 4.41e-10

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 59.97  E-value: 4.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGN-VCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWT-EAWLLGPVACHLLFYVMTLS 121
Cdd:cd14982     4 PIVYSLIFILGLLGNiLALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNgGWWPFGDFLCRLTGLLFYIN 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 122 GSVTILTLAAVSLERMVCIVH--LQRGVRgpgRRARAVLL-ALIWGYSAVAALPLCVFfrvvpQRLPGADQEISICTLIW 198
Cdd:cd14982    84 MYGSILFLTCISVDRYLAVVHplKSRRLR---RKRYAVGVcAGVWILVLVASVPLLLL-----RSTIAKENNSTTCFEFL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 199 PTIPGE-ISWDVSFVTLNFLVPGLVIVISYSKILqitkasRKRLTVSLAYSESHQIRvsqqdfRLFRTLFLLMVSFFIMW 277
Cdd:cd14982   156 SEWLASaAPIVLIALVVGFLIPLLIILVCYSLII------RALRRRSKQSQKSVRKR------KALRMILIVLAVFLVCF 223
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1835884573 278 SP--IIITILLILIQNFKQDLVIWPSLFFW---VVAFTFANSALNPILY 321
Cdd:cd14982   224 LPyhVTRILYLLVRLSFIADCSARNSLYKAyriTLCLASLNSCLDPLIY 272
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
45-321 6.36e-10

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 59.35  E-value: 6.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGNVCALVLVARRRRRG---ATACLVLNLFCADLLFISAIPLVLAVRWTEA-WLLGPVACHLLFYVMTL 120
Cdd:cd15002     4 ILLGVICLLGFAGNLMVIGILLNNARKGkpsLIDSLILNLSAADLLLLLFSVPFRAAAYSKGsWPLGWFVCKTADWFGHA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 121 SGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLAlIWGYSAVAALPLCVFFRVVPQrlpgADQEISICTLIWPT 200
Cdd:cd15002    84 CMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRITAVVAS-IWVPACLLPLPQWLFRTVKQS----EGVYLCILCIPPLA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 201 IPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRkrltvslaySESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPI 280
Cdd:cd15002   159 HEFMSAFVKLYPLFVFCLPLTFALFYFWRAYGQCQRRG---------TKTQNLRNQIRSRKLTHMLLSVVLAFTILWLPE 229
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1835884573 281 IITILLILIQnfkQDLVIWPSLFFWVVA--FTFANSALNPILY 321
Cdd:cd15002   230 WVAWLWLIHI---KSSGSSPPQLFNVLAqlLAFSISSVNPIIF 269
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
45-323 8.06e-10

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 58.88  E-value: 8.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGNVCALVLVARRRRRGATA-CLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSG 122
Cdd:cd15064     5 VLLSLIILATILGNALVIAAILLTRKLHTPAnYLIASLAVADLLVaVLVMPLSAVYELTGRWILGQVLCDIWISLDVTCC 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 123 SVTILTLAAVSLERMVCIV-HLQRGVRGPGRRArAVLLALIWGYSAVAALPlCVFFRVVPQRlpgadQEISICTliwpti 201
Cdd:cd15064    85 TASILHLCVIALDRYWAITdAVEYAHKRTPKRA-AVMIALVWTLSICISLP-PLFGWRTPDS-----EDPSECL------ 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 202 pgeISWDVS---FVTLN-FLVPGLVIVISYSKILQITKASRKRLtvslayseshqirvsqqdfrlfRTLFLLMVSFFIMW 277
Cdd:cd15064   152 ---ISQDIGytiFSTFGaFYIPLLLMLILYWKIYRAAARERKAA----------------------KTLGIILGAFIVCW 206
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1835884573 278 SPIIITILLILIQNFKQDLVIWPSLFFWVvafTFANSALNPILYNM 323
Cdd:cd15064   207 LPFFLVALIVPLCSHCWIPLALKSFFLWL---GYFNSLINPLIYTF 249
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
79-321 1.05e-09

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 58.85  E-value: 1.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  79 LNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAV 157
Cdd:cd15048    40 LNLAVADFLVgLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDYTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVL 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 158 LLALIWGYSAVAALPLCVFFRVVPQR--LPGADQEISICTliwptipgeiSWDVSFVT--LNFLVPGLVIVISYSKI-LQ 232
Cdd:cd15048   120 LMALVWILAFLLYGPAIIGWDLWTGYsiVPTGDCEVEFFD----------HFYFTFITsvLEFFIPFISVSFFNLLIyLN 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 233 ITKASRKRLTVSLAYSESHQIRVSQ----------QDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSL 302
Cdd:cd15048   190 IRKRSRRRPLRSVPILPASQNPSRArsqreqvklrRDRKAAKSLAILVLVFLICWAPYTILTIIRSFCSGSCVDSYLYEF 269
                         250
                  ....*....|....*....
gi 1835884573 303 FFWVVaftFANSALNPILY 321
Cdd:cd15048   270 TFWLL---WTNSAINPFLY 285
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
77-325 1.41e-09

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 58.50  E-value: 1.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRAR 155
Cdd:cd15083    38 LIINLAISDFLMcILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 156 AVLLALIWGYSAVAAL-PLCVFFRVVPQRLpgadqeISICTL-IWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQI 233
Cdd:cd15083   118 LIVIAVVWLYSLLWVLpPLFGWSRYVLEGL------LTSCSFdYLSRDDANRSYVICLLIFGFVLPLLIIIYCYSFIFRA 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 234 TKASRKRLT----VSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILiqnFKQDLVIWPSLFFWVVAF 309
Cdd:cd15083   192 VRRHEKAMKemakRFSKSELSSPKARRQAEVKTAKIALLLVLLFCLAWTPYAVVALIGQ---FGYLEVLTPLATAIPAAF 268
                         250
                  ....*....|....*.
gi 1835884573 310 TFANSALNPILYNMTL 325
Cdd:cd15083   269 AKTSAIYNPVIYAFSH 284
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
74-321 1.85e-09

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 58.06  E-value: 1.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLF-ISAIPLVL---AVRwTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHlqRGVRG 149
Cdd:cd15204    35 TNLLIANLALSDFLVaVFCLPFEMdyyVVR-QRSWTHGDVLCAVVNYLRTVSLYVSTNALLVIAIDRYLVIVH--PLKPR 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 150 PGRRARAVLLALIWGYSAVAALPLCVFFRVVPQrlpgADQEISICTLIWPtIPGEISWDVSFVTL---NFLVPGLVIVIS 226
Cdd:cd15204   112 MKRRTACVVIALVWVVSLLLAIPSAVYSKTTPY----ANQGKIFCGQIWP-VDQQAYYKAYYLFLfvlEFVLPVLIMTLC 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 227 YSKIlqitkaSRKRLTVSLAYSESHQIRVSQQ-DFRLFRTLFLLMVSFFIMWSPiiiTILLILIQNFKQDLVIWPSL--- 302
Cdd:cd15204   187 YLRI------VRKVWFRRVPGQQTEQIRRRLRrRRRKVRLLVVILTAFVLCWAP---YYGYAIVRDFFPTLLSKEKLntt 257
                         250       260
                  ....*....|....*....|
gi 1835884573 303 -FFWVVAFTFANSALNPILY 321
Cdd:cd15204   258 iFYIVEALAMSNSMINTVVY 277
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-321 1.91e-09

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 58.23  E-value: 1.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGN--VCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTE-AWLLGPVACHLLFYVMTLS 121
Cdd:cd15190    15 VIYMLVFVLGLSGNglVLWTVFRSKRKRRRSADTFIANLALADLTFVVTLPLWAVYTALGyHWPFGSFLCKLSSYLVFVN 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 122 GSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPG---ADQEISICTLIW 198
Cdd:cd15190    95 MYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSDLEGTNkviCDMDYSGVVSNE 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 199 PTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQitkasrkrlTVSLAYSeSHQIRVSQQDFRLFRTLFLLMVSFFIMWS 278
Cdd:cd15190   175 SEWAWIAGLGLSSTVLGFLLPFLIMLTCYFFIGR---------TVARHFS-KLRRKEDKKKRRLLKIIITLVVTFALCWL 244
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1835884573 279 PIIITILLILIqnFKQDLVIWPSLF--FWVVAFTFA------NSALNPILY 321
Cdd:cd15190   245 PFHLVKTLYAL--MYLGILPFSCGFdlFLMNAHPYAtclayvNSCLNPFLY 293
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
41-279 2.09e-09

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 57.86  E-value: 2.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  41 AVETTVLVLIFAVSLLGNVCALVLVARRRRRGA-TACLVLNLFCADLLFISAIPLVlAVRWTEAWLLGPVACHLLFYVMT 119
Cdd:cd15177     1 VFQPCVYLVVFVLGLVGNGLVLATHTRYRRLRSmTDVYLLNLALADLLLLLTLPFA-AAETLQGWIFGNAMCKLIQGLYA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 120 LSGSVTILTLAAVSLERMVCIVH-LQRGVRGPGRRARAVLLALI-WGYSAVAALPLCVFFRVVPQrlpgadQEISICTLI 197
Cdd:cd15177    80 INFYSGFLFLTCISVDRYVVIVRaTSAHRLRPKTLFYSVLTSLIvWLLSILFALPQLIYSRVENR------SELSSCRMI 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 198 WPTIPGEISWDVSFVT---LNFLVPGLVIVISYSKILQITKASRkrltvslayseshqirvSQQDFRLFRTLFLLMVSFF 274
Cdd:cd15177   154 FPEVVSRTVKGATALTqvvLGFAIPLIVMAVCYAAIGRTLLAAR-----------------GWERHRALRVIAALVVAFV 216

                  ....*
gi 1835884573 275 IMWSP 279
Cdd:cd15177   217 LFQLP 221
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
44-332 2.67e-09

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 57.58  E-value: 2.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCALVLVARRRRRGATA--CLVLNLFCADLLFISAIPLVLAVRWTE-AWLLGPVACHLLFYVMTL 120
Cdd:cd15925     4 ALAYGLVCAIGLLGNLAVMYLLRNCARRAPPPidVFVFNLALADFGFALTLPFWAVESALDfHWPFGGAMCKMVLTATVL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 121 SGSVTILTLAAVSLERMVCIVH-LQRGVRGPGRRARAVLLALiWGYSAVAALPLCVF---FRVVPQRLpgadqeisiCTL 196
Cdd:cd15925    84 NVYASVFLLTAMSVTRYWVVASaAGPGTHLSTFWAKIITLAL-WAAALLATVPTAIFateGEVCGVEL---------CLL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 197 IWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKrltvslayseshQIRVSQQDFRLFRTLFLLMVSFFIM 276
Cdd:cd15925   154 KFPSNYWLGAYHLQRVVVAFVVPLGVITTSYLLLLSFLQQHKV------------NQNNRQRQSVIARSVRLVVASFFLC 221
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1835884573 277 WSPIIITILLILIQNFkqDLVIWPSLFFWVVAFTF--------ANSALNPILYnmTLCRNEWKK 332
Cdd:cd15925   222 WFPNHVVTFWGVLVKF--RAVPWNSTFYFIHTYVFpvttclahSNSCLNPVLY--CLMRREFRQ 281
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
77-279 3.06e-09

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 57.28  E-value: 3.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLFI-SAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRAR 155
Cdd:cd15927    38 FILSLALGDLLLLlTCVPFTSTIYTLDSWPFGEFLCKLSEFLKDTSIGVSVFTLTALSADRYFAIVNPMRKHRSQATRRT 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 156 AVLLALIWGYSAVAALPLCVFFRVVPQRLPGaDQEISICT----LIWPTIPGEISWdVSFVTLnFLVPGLVIVISYSKIL 231
Cdd:cd15927   118 LVTAASIWIVSILLAIPEAIFSHVVTFTLTD-NQTIQICYpypqELGPNYPKIMVL-LRFLVY-YLIPLLIIGVFYVLMA 194
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1835884573 232 QITKASRKRLTVSLAYSESHQIRVSQqdfRLFRTLFLLMVSFFIMWSP 279
Cdd:cd15927   195 RHLIRSTRNIGSGQNQAAQRQIEARK---KVAKTVLAFVVLFAVCWLP 239
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
46-321 3.47e-09

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 56.99  E-value: 3.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  46 VLVLIFAVSLLGN--VCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGS 123
Cdd:cd15213     6 LMILMIFVGFLGNsiVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWFFVL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 124 VTILTLAAVSLERMVCIVhlQRGVRGPGRRARaVLLALIWGYSAVAALPLCVFFRVVpQRLPGADQeisiCTLIWPTIPG 203
Cdd:cd15213    86 EGVAILLIISVDRYLIIV--QRQDKLNPHRAK-ILIAVSWVLSFCVSFPPLVGWGKY-EFPPRAPQ----CVLGYTESPA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 204 EISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKrltvslayseshqirvsqqdfRLFRTLFLLMVSFFIMWSPIIIT 283
Cdd:cd15213   158 DRIYVVLLLVAVFFIPFLIMLYSYFCILNTVRSFKT---------------------RAFTTILILFIGFSVCWLPYTVY 216
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1835884573 284 ILLIliqNFKQDLVIWPSLFFWVVAFTFANSALNPILY 321
Cdd:cd15213   217 SLLS---VFSRYSSSFYVISTCLLWLSYLKSAFNPVIY 251
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
44-239 3.76e-09

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 57.48  E-value: 3.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHL---LFYVMTL 120
Cdd:PHA03087   44 IVVYSTIFFFGLVGNIIVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIvsgLYYIGFY 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 121 SGsvtILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVvpqrlpGADQEISIC------ 194
Cdd:PHA03087  124 NS---MNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTT------KKDHETLICcmfynn 194
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1835884573 195 -TLIWPTIpgeISWDVSFvtLNFLVPGLVIVISYSKILQITKASRK 239
Cdd:PHA03087  195 kTMNWKLF---INFEINI--IGMLIPLTILLYCYSKILITLKGINK 235
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
50-321 3.84e-09

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 57.13  E-value: 3.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  50 IFAVSLLGNVCAL-VLVARRRRRGATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTIL 127
Cdd:cd15202    10 IIVFSLFGNVLVCwIIFKNQRMRTVTNYFIVNLAVADIMItLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHVSAY 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 128 TLAAVSLERMVCIVH-LQRGVrgpGRRARAVLLALIWGYSAVAALPLCVFFRVVPQrLPGADQEISICTLIWPTiPGEIS 206
Cdd:cd15202    90 TLTAIAVDRYQAIMHpLKPRI---SKTKAKFIIAVIWTLALAFALPHAICSKLETF-KYSEDIVRSLCLEDWPE-RADLF 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 207 W---DVSFVTLNFLVPGLVIVISYSkilqitkasrkRLTVSLAYSESHQIRVSQQDFRLFRT-------LFLLMVSFFIM 276
Cdd:cd15202   165 WkyyDLALFILQYFLPLLVISFAYA-----------RVGIKLWASNMPGDATTERYFALRRKkkkvikmLMVVVVLFALC 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1835884573 277 WSPIIITILLILIQNFKQDLVIwPSLFFWVVAFTFANSALNPILY 321
Cdd:cd15202   234 WLPFNIYVLLLSSKPDYLIKTI-NAVYFAFHWLAMSSTCYNPFIY 277
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
46-321 3.99e-09

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 56.76  E-value: 3.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  46 VLVLIFAVSLLGN--VCALVLVARRRRRGATACLVLNLFCADLLFI-SAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSG 122
Cdd:cd15097     6 VFSLIFLLGTVGNslVLAVLLRSGQSGHNTTNLFILNLSVADLCFIlFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLTM 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 123 SVTILTLAAVSLERMVCIVH--LQRGVRGPgRRARAVlLALIWGYSAVAALPLCVFFRVVPQrlpgadQEISICTLIWPT 200
Cdd:cd15097    86 YASSFTLAAVSVDRYLAIRYplRSRELRTP-RNAVAA-IALIWGLSLLFAGPYLSYYDLIDY------ANSTVCMPGWEE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 201 iPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTvslAYSESHQIRVsqqdfRLFRTLFLLMVSFFIMWSPI 280
Cdd:cd15097   158 -ARRKAMDTCTFAFGYLIPVLVVSLSYTRTIKYLWTAVDPLE---AMSESKRAKR-----KVTKMIIIVTALFCLCWLPH 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1835884573 281 IITILLILIQNFKQDLVIWpSLFFWVVAFTFANSALNPILY 321
Cdd:cd15097   229 HVVILCYLYGDFPFNQATY-AFRLLSHCMAYANSCLNPIVY 268
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
42-321 4.41e-09

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 56.62  E-value: 4.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  42 VETTVLVLIFAVSLLGNVCALVLVARRRRRGA-TACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMT 119
Cdd:cd15066     1 LKGFAMTLIILAAIFGNLLVIISVMRHRKLRViTNYFVVSLAMADMLVaLCAMTFNASVEITGRWMFGYFMCDVWNSLDV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 120 LSGSVTILTLAAVSLERMVCIVH-LQRGVRGPGRRArAVLLALIWGYSA-VAALPLCVFFRVVPQRLPGADQEISICTLI 197
Cdd:cd15066    81 YFSTASILHLCCISVDRYYAIVQpLEYPSKMTKRRV-AIMLANVWISPAlISFLPIFLGWYTTEEHLQYRKTHPDQCEFV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 198 WPTIPGEISWDVSFvtlnfLVPGLVIVISYSKILQITKASRKRLtvslayseshqirvsqqdfrlfRTLFLLMVSFFIMW 277
Cdd:cd15066   160 VNKIYALISSSVSF-----WIPCIVMIFTYYRIYLEAKREHKAA----------------------KTLGIIMGAFILCW 212
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1835884573 278 SPIIITILLIliqNFKQDLVIWP----SLFFWVVAFtfaNSALNPILY 321
Cdd:cd15066   213 LPFFLWYVTT---TLCGDACPYPpilvSILFWIGYF---NSTLNPLIY 254
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
77-324 4.47e-09

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 56.82  E-value: 4.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRArA 156
Cdd:cd15079    38 LVVNLAISDFLMMIKMPIFIYNSFYEGWALGPLGCQIYAFLGSLSGIGSIWTNAAIAYDRYNVIVKPLNGNPLTRGKA-L 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 157 VLLALIWGYSAV-AALPLCVFF-RVVPQRLPGAdqeisiCTLIWPTipgEISWDVSFVTLNFL----VPGLVIVISYSKI 230
Cdd:cd15079   117 LLILFIWLYALPwALLPLLFGWgRYVPEGFLTS------CSFDYLT---RDWNTRSFVATIFVfayvIPLIIIIYCYSFI 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 231 LQITKASRKRLT--------VSLAYSESHQirvsQQ--DFRLFRTLFLLMVSFFIMWSPIIITILLILIQNfkQDLV--- 297
Cdd:cd15079   188 VKAVFAHEKALReqakkmnvVSLRSNADAN----KQsaEIRIAKVALTNVFLWFIAWTPYAVVALIGAFGN--QSLLtpl 261
                         250       260
                  ....*....|....*....|....*....
gi 1835884573 298 --IWPSLffwvvaFTFANSALNPILYNMT 324
Cdd:cd15079   262 vsMIPAL------FAKTAACYNPIVYAIS 284
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
49-321 4.67e-09

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 56.68  E-value: 4.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  49 LIFAVSLLGNVCALVLVARRRRRGATACL-VLNLFCADLLFISAIPLVLAV-RWTEAWLLGPVACHLLFYVMTLSGSVTI 126
Cdd:cd15191     9 IIFILGFLGNSLVVCVFCHQSGPKTVASIyIFNLAVADLLFLATLPLWATYySYGYNWLFGSVMCKICGSLLTLNLFASI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 127 LTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLaLIWGYSAVAALPLCVFFRVVPQRLPGadqeISICTLIWPTiPGEIS 206
Cdd:cd15191    89 FFITCMSVDRYLAVVYPLRSQRRRSWQARLVCL-LVWVLACLSSLPTFYFRDTYYIEELG----VNACIMAFPN-EKYAQ 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 207 WDVSFV----TLNFLVPGLVIVISYSKIlqitkasRKRLTVSLAYSESHQIRVsqqdfRLFRTLFLLMVSFFIMWSPIII 282
Cdd:cd15191   163 WSAGLAlmknTLGFLIPLIVIATCYFGI-------GRHLLKTKGFGKNKQRRD-----KVLKMVAAVVLAFLICWFPFHV 230
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1835884573 283 TILLiliqnfkqDLVIWPSLFF--WVVAFT-----------FANSALNPILY 321
Cdd:cd15191   231 LTFL--------DALARMGVINncWVITVIdkalpfaiclgFSNSCINPFLY 274
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
78-323 4.81e-09

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 56.74  E-value: 4.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  78 VLNLFCADLLFISAIPLVL-AVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARA 156
Cdd:cd15338    42 IFNLSIVDLLFLLGMPFLIhQLLGNGVWHFGETMCTLITALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAV 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 157 VLLALIWGYSAVAALPLCVFFRVVPqrLPGADQEisiCTLIWPTIPGEISWDVSF-VTLNFLVPGLVIVISYSKILQitk 235
Cdd:cd15338   122 AVICLVWILSLLSITPVWMYAGLMP--LPDGSVG---CALLLPNPETDTYWFTLYqFFLAFALPLVVICVVYFKILQ--- 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 236 asrkRLTVSLAYSESHQIRVSQQdfRLFRTLFLLMVSFFIMWSPIIITILLILIqnFKQDLVIWPSLFFWVVAFTFANSA 315
Cdd:cd15338   194 ----NMASTVAPLPQRSLRVRTK--KVTRMAVAICLAFFICWAPFYILQLAHLS--IDRPSLAFLYAYNVAISMGYANSC 265

                  ....*...
gi 1835884573 316 LNPILYNM 323
Cdd:cd15338   266 INPFLYIM 273
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
45-240 8.31e-09

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 55.91  E-value: 8.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRW-TEAWLLGPVACHLL--FYVMTLS 121
Cdd:cd15372     5 SLYTLVFLVGLPANGLALWVLATQVKRLPSTIFLINLAVADLLLILVLPFKISYHFlGNNWPFGEGLCRVVtaFFYGNMY 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 122 GSVtiLTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFfrvvPQRLPGADQEISICTLIWPTI 201
Cdd:cd15372    85 CSV--LLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQ----RQSYPLERLNITLCHDVLPLD 158
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1835884573 202 PGEISWDVSFVTL---NFLVPGLVIVISYSKILQITKASRKR 240
Cdd:cd15372   159 EQDTYLFYYFACLavlGFLLPLVVILFCYGSVLHTLLRSGQR 200
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
41-321 8.87e-09

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 55.80  E-value: 8.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  41 AVETTVLVLIFAVSLLGN--VCALVLVARRRRRgATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYV 117
Cdd:cd15051     1 IVLGVVLAVIILLTVIGNvlVCLAVAVNRRLRN-LTNYFIVSLAVTDLLLgLLVLPFSAIYELRGEWPLGPVFCNIYISL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 118 MTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYS-AVAALPLCVFFRVVPQRLPGADQEiSICTL 196
Cdd:cd15051    80 DVMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSlAVSFLPIHLGWNTPDGRVQNGDTP-NQCRF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 197 IWPTIPGEIswdVSFVTlnFLVPGLVIVISYSKILQITKASRKR---LTVSLAYSESHQIRvSQQDFRLFRTLFLLMVSF 273
Cdd:cd15051   159 ELNPPYVLL---VAIGT--FYLPLLIMCGVYLRIFRIAREQAKRinaLTPASTANSSKSAA-TAREHKATVTLAAVLGAF 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1835884573 274 FIMWSPIIITILLIliqNFKQDLVIWPSLFFwVVAFTFANSALNPILY 321
Cdd:cd15051   233 IICWFPYFTYFTYR---GLCGDNINETALSV-VLWLGYANSALNPILY 276
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
78-333 9.42e-09

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 55.96  E-value: 9.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  78 VLNLFCADLLFISAIPL-VLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARA 156
Cdd:cd15118    38 ILNLALSDLLATLSLPFfTYYLASGHTWELGTTFCRIHSSIFFLNMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAK 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 157 VLLALIWGYSAVAALPLCVFFRVVP-------------QRLPGADQEISICTLiwptipGEISWDVSFVTLNFLVPGLVI 223
Cdd:cd15118   118 KICGVIWAMALINTIPYFVFRDVIErkdgrklcyynfaLFSPSPDNNHPICKQ------RQEGLAISKLLLAFLIPLVII 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 224 VISYSKILQITKASRKRltvslayseshqirvsqQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDL--VIWPS 301
Cdd:cd15118   192 AVSYAVVSLIIRHRCRR-----------------RPGRFVRLVVSVVVSFALCWAPYHIFSIIEVMAHNQHSLrpLVIQG 254
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1835884573 302 LFFwVVAFTFANSALNPILYNMTlCRNEWKKI 333
Cdd:cd15118   255 LPF-ATTLAFLNSVLNPVLYVFS-CPDFCNKI 284
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
45-321 1.02e-08

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 55.90  E-value: 1.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGNVCALVLVARRRRRGATACL-VLNLFCADLLFISAIPLVLAVRWTE-AWLLGPVACHLLFYVMTLSG 122
Cdd:cd15192     5 TVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIfLLNLALADLCFLITLPLWAAYTAMEyHWPFGNFLCKIASALVSFNL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 123 SVTILTLAAVSLERMVCIVHLQRgvrgpGRRARAVLLA-----LIWGYSAVAALPLCVFFRVVPQrlpgADQEISICTLI 197
Cdd:cd15192    85 YASVFLLTCLSIDRYLAIVHPMK-----SRLRRTLVVArvtciVIWLLAGVASLPAIIHRDVFFI----ENTNITVCAFH 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 198 WPTIPGEISWDVSFVT--LNFLVPGLVIVISYSKILQITKASRkrltvslaysesHQIRVSQQDFRLFRTLFLLMVSFFI 275
Cdd:cd15192   156 YPSQNSTLLVGLGLMKnlLGFLIPFLIILTCYTLIGKALKKAY------------EIQRNKPRNDEIFKMIMAVVLFFFF 223
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1835884573 276 MWSP------IIITILLILIQNFKQDLVIWPSLFFwVVAFTFANSALNPILY 321
Cdd:cd15192   224 CWIPhqiftfLDVLIQLKVIQDCHIADIVDTAMPF-TICIAYFNSCLNPILY 274
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
74-230 1.15e-08

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 55.59  E-value: 1.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHlQRGVRgPGR 152
Cdd:cd15395    35 TNILIVNLSFSDLLMtIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQCISITVSIFSLVLIAIERHQLIIN-PRGWR-PNN 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 153 RARAVLLALIWGYSAVAALPLCVFFRVV--PQRLPGADQEI----SICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVIS 226
Cdd:cd15395   113 RHAYVGIAVIWVLAVLTSLPFLIFQVLTdePFKNVNVSLDAykgkYVCLDQFPSDTIRLSYTTCLLVLQYFGPLCFIFIC 192

                  ....
gi 1835884573 227 YSKI 230
Cdd:cd15395   193 YLKI 196
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
45-321 1.79e-08

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 54.82  E-value: 1.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAvRWTEA--WLLGPVACHLLFYVMTLSG 122
Cdd:cd15339     5 SFIGILCSTGLVGNILVLFTIIRSRKKTVPDIYVCNLAVADLVHIIVMPFLIH-QWARGgeWVFGSPLCTIITSLDTCNQ 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 123 SVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRlpgadQEISICTLIWpTIP 202
Cdd:cd15339    84 FACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKFR-----DGLESCAFNL-TSP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 203 GEISWDVSFVT-LNFLVPGLVIVISYSKILQITKASRKRLTVSLAYSESHQirvSQQDFRLFRTLFLLMVSFFIMWSPII 281
Cdd:cd15339   158 DDVLWYTLYQTiTTFFFPLPLILICYILILCYTWEMYRKNKKAGRYNTSIP---RQRVMRLTKMVLVLVGVFLVSAAPYH 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1835884573 282 ITILLILIqnfkqdlVIWPSLFFWV-----VAFTFANSALNPILY 321
Cdd:cd15339   235 VIQLVNLS-------VSQPTLAFYVsyylsICLSYASSSINPFLY 272
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
77-279 3.36e-08

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 54.30  E-value: 3.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLFISAI-PLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIvhLQRGVRGPGRRAR 155
Cdd:cd15383    39 LILHLAAADLLVTFVVmPLDAAWNVTVQWYAGDLACRLLMFLKLFAMYSSAFVTVVISLDRHAAI--LNPLAIGSARRRN 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 156 AVLLALIWGYSAVAALPLCVFFRVVpQRLPGADQEISICTLIWPTIPGEISWDV-SFVTLnFLVPGLVIVISYSKIL-QI 233
Cdd:cd15383   117 RIMLCAAWGLSALLALPQLFLFHTV-TATPPVNFTQCATHGSFPAHWQETLYNMfTFFCL-FLLPLLIMIFCYTRILlEI 194
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1835884573 234 TKASRKRLTVSLAYSESHQI--RVSQQDFRLFRTLFLLMVSFFIMWSP 279
Cdd:cd15383   195 SRRMKEKKDSAKNEVALRSSsdNIPKARMRTLKMTIVIVSSFIVCWTP 242
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
80-321 3.49e-08

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 54.01  E-value: 3.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  80 NLFCADLLFISAIPLVLAVRWTE-AWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVL 158
Cdd:cd15189    41 NLAAADLVFVSGLPFWAMNILNQfNWPFGELLCRVVNGVIKVNLYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLI 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 159 LALIWGYSAVAALPLCVFFRVvpQRLPgaDQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQitkasr 238
Cdd:cd15189   121 CVLIWVVGLLLSIPTFLLRKI--KAIP--DLNITACVLLYPHEAWHFAHIVLLNIVGFLLPLLVITFCNYNILQ------ 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 239 krltvSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLiliqNFKQDLVIWPSLFFW---------VVAF 309
Cdd:cd15189   191 -----ALRTREESTRCEDRNDSKATALVLAVTLLFLVCWGPYHFFTFL----DFLFDVGVLDECFWEhfidiglqlAVFL 261
                         250
                  ....*....|..
gi 1835884573 310 TFANSALNPILY 321
Cdd:cd15189   262 AFSNSCLNPVLY 273
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
78-321 3.57e-08

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 53.93  E-value: 3.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  78 VLNLFCADLLFISAIPLVLA-VRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARA 156
Cdd:cd15160    39 LLNLSLSDLLYILTLPLWIDyTANHHNWTFGPLSCKVVGFFFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFAL 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 157 VLLALIWgysAVAALPLCVFFRVvpQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKA 236
Cdd:cd15160   119 KVSASIW---VLELGTHSVFLGH--DELFRDEPNHTLCYEKYPMEGWQASYNYARFLVGFLIPLSLILFFYRRVLRAVRQ 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 237 SrkrltVSLAYSESHQIRvsqqdfrlfRTLFLLMVSFFIMWSP--------IIITILLILIQNFKQDLVIWPSLFFwvvA 308
Cdd:cd15160   194 S-----PSLEREEKRKII---------GLLLSIVVIFLLCFLPyhvvllvrSVIELVQNGLCGFEKRVFTAYQISL---C 256
                         250
                  ....*....|...
gi 1835884573 309 FTFANSALNPILY 321
Cdd:cd15160   257 LTSLNCVADPILY 269
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
46-247 4.52e-08

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 53.61  E-value: 4.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  46 VLVLIFAVSLLGNVCALVLVARRRRRGA-TACLVLNLFCADLLFISAIPLVlAVRWTEAWLLGPVACHLLFYVMTLSGSV 124
Cdd:cd15172     6 IYSLICVVGLIGNSLVVITYAFYKRTKSmTDVYLLNMAIADILFVLTLPFW-AVYEAHQWIFGNFSCKLLRGIYAINFYS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 125 TILTLAAVSLERMVCIVHLQRGVRgpgRRARA-----VLLALIWGYSAVAALPLCVFFRVVPQRLPGADqeisICTLIWP 199
Cdd:cd15172    85 GMLLLACISVDRYIAIVQATKSFR---LRSRTlayskLICAAVWLLAILISLPTFIFSEVYDFGLEEQY----VCEPKYP 157
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1835884573 200 TIPGEISWDV----SFVTLNFLVPGLVIVISYSKI---------LQITKASRKRLTVSLAY 247
Cdd:cd15172   158 KNSTAIMWKLlvlsLQVSLGFFIPLLVMIFCYSFIiktllqaqnSQRHKAVRVVVAVVLVF 218
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
45-321 4.60e-08

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 53.60  E-value: 4.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGNVCALVLVARRRRRGATA-CLVLNLFCADLLFISAIPL-VLAVRWTEAWLLGPVACHLLFYVMTLSG 122
Cdd:cd15193     5 ILYLIIFFTGLLGNLFVIALMSKRSTTKRLVdTFVLNLAVADLVFVLTLPFwAASTALGGQWLFGEGLCKLSSFIIAVNR 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 123 SVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIwptip 202
Cdd:cd15193    85 CSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRNLINESVCVEDSSSRFFQGI----- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 203 geiswDVSFVTLNFLVPGLVIVISYSKILqitkasrkrltVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSP--- 279
Cdd:cd15193   160 -----SLATLFLTFVLPLIVILFCYCSIL-----------VRLRRHFHGAKRTGRRRRNSLRIVFAIVTAFVLSWLPfnt 223
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1835884573 280 --IIITILLILIQNFKQDL-VIWPSLFFWVVAFTFANSALNPILY 321
Cdd:cd15193   224 lkAVRLLLELGGGVLPCHTtVAIRQGLTITACLAFVNSCVNPLIY 268
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
49-334 5.48e-08

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 53.41  E-value: 5.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  49 LIFAVSLLGNVCALVLVARRRRRGATACLVL-NLFCADLLFIS-AIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTI 126
Cdd:cd15322     9 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLvSLASADILVATlVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 127 LTLAAVSLERMVCIVH-LQRGVRGPGRRARAVLLaLIWGYSAVAALPlcvffRVVPQRLPGADQEISICtliwpTIPGEI 205
Cdd:cd15322    89 VHLCAISLDRYWSITQaIEYNLKRTPRRIKCIIF-IVWVISAVISFP-----PLITIEKKSGQPEGPIC-----KINDEK 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 206 SWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTVSLAyseshqirvsqqdfrlfrtlfLLMVSFFIMWSPIIITIL 285
Cdd:cd15322   158 WYIISSCIGSFFAPCLIMVLVYIRIYQIAKNREKRFTFVLA---------------------VVIGVFVICWFPFFFTYT 216
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1835884573 286 LILIQNFKQDLVIWpSLFFWvvaFTFANSALNPILYnmTLCRNEWKKIF 334
Cdd:cd15322   217 LTAVCDCSVPETLF-KFFFW---FGYCNSSLNPVIY--TIFNHDFRRAF 259
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
73-321 6.02e-08

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 53.33  E-value: 6.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  73 ATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRG--VRGP 150
Cdd:cd15092    34 ATNIYIFNLALADTLVLLTLPFQGTDIFLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIKAldVRTP 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 151 gRRARAVLLAlIWGYSAVAALPLCVFFRVVPQrlpgaDQEISiCTLIWPtiPGEISWDVSFVT----LNFLVPGLVIVIS 226
Cdd:cd15092   114 -HKAKVVNVC-IWALASVVGVPVMVMGSAQVE-----DEEIE-CLVEIP--TPQDYWDPVFGIcvflFSFIIPVLIISVC 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 227 YSKILQITKASRkrlTVSLAYSESHQIRvsqqdfRLFRTLFLLMVSFFIMWSPIIITILLILIqNFKQDLVIWPSLFFWV 306
Cdd:cd15092   184 YSLMIRRLRGVR---LLSGSKEKDRNLR------RITRLVLVVVAVFVGCWTPIQIFVLAQGL-GVQPSSETAVAILRFC 253
                         250
                  ....*....|....*
gi 1835884573 307 VAFTFANSALNPILY 321
Cdd:cd15092   254 TALGYVNSSLNPVLY 268
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
46-321 7.43e-08

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 53.20  E-value: 7.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  46 VLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIP-LVLAVRWTEAWLLGPVACHLL--FYVMTLSG 122
Cdd:cd15117     6 IYSSAFVLGTLGNGLVIWVTGFRMTRTVTTVCFLNLAVADFAFCLFLPfSVVYTALGFHWPFGWFLCKLYstLVVFNLFA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 123 SVTILTLaaVSLERMVCIVH--LQRGVRGPgrrARAVLLAL-IWGYSAVAALPLCVF-------------FRVVPQRLPG 186
Cdd:cd15117    86 SVFLLTL--ISLDRCVSVLWpvWARNHRTP---ARAALVAVgAWLLALALSGPHLVFrdtrkengcthcyLNFDPWNETA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 187 ADQEISICTliwpTIPGEISWDVSFVTLNFLVPGLVIVISYSKIlqITKASRKRLTVSLayseshqirvsqqdfRLFRTL 266
Cdd:cd15117   161 EDPVLWLET----VVQRLSAQVITRFVLGFLVPLVIIGGCYGLI--AARLWREGWVHSS---------------RPFRVL 219
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1835884573 267 FLLMVSFFIMWSP--IIITILLILIQNFKQDLVIW-PSLFFWVVAFTFANSALNPILY 321
Cdd:cd15117   220 TAVVAAFFLCWFPfhLVSLLELVVILNQKEDLNPLlILLLPLSSSLACVNSCLNPLLY 277
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
49-279 7.72e-08

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 52.91  E-value: 7.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  49 LIFAVSLLGNVCALVLVARRRRRG-ATACLVLNLFCADLLFISAIPL-VLAVRWTEaWLLGPVACHLL--FYVMTLSGSV 124
Cdd:cd15185     9 LVFIVGLLGNVVVVVILIKYRRLRiMTNIYLLNLAISDLLFLFTLPFwIHYVRWNN-WVFGHGMCKLLsgFYYLGLYSEI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 125 TILTLaaVSLERMVCIVHLQRGVRgpgrrARAVLLALI-----WGYSAVAALPLCVFFRVvpqrlpGADQEISICTLIWP 199
Cdd:cd15185    88 FFIIL--LTIDRYLAIVHAVFALR-----ARTVTFGIItsiitWGLAVLAALPEFIFYET------QELFEEFLCSPLYP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 200 TiPGEISWD----VSFVTLNFLVPGLVIVISYSKILQITkasrkrltvslayseshqIRV-SQQDFRLFRTLFLLMVSFF 274
Cdd:cd15185   155 E-DTEDSWKrfhaLRMNIFGLALPLLIMVICYTGIIKTL------------------LRCpSKKKYKAIRLIFVIMVVFF 215

                  ....*
gi 1835884573 275 IMWSP 279
Cdd:cd15185   216 IFWTP 220
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
45-279 1.56e-07

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 52.14  E-value: 1.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGNVCALVLVARRR-RRGATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSG 122
Cdd:cd15396     5 IAYSVVTIVGLFGNLCLITIIKKQKeEHNVTNILIANLSLSDVLVcVMCIPFTAVYTLMDHWIFGETMCKLTSFVQSVSV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 123 SVTILTLAAVSLERMVCIVHlQRGVRgPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRL------PGADQEISICTL 196
Cdd:cd15396    85 SVSIFSLVLIAIERYQLIVN-PRGWK-PSASHAYWGIVLIWLFSLMISIPFLIFHQLTDEPFrnlsshSDFYKDKVVCIE 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 197 IWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKaSRKRLTVSLAYSEShqiRVSQQDfRLFRTLFLLMVSFFIM 276
Cdd:cd15396   163 AWPSETERLIFTTSLLVFQYFVPLGFIFICYLKIFVCLK-KRNSKIDRMRENES---RLSENK-RINTMLISIVVTFAAC 237

                  ...
gi 1835884573 277 WSP 279
Cdd:cd15396   238 WLP 240
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
46-321 1.59e-07

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 52.06  E-value: 1.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  46 VLVLIFAVSLLGNVCALVLVARRRRR-GATACLVLNLFCADLLFISAIPLVLAVRWT-EAWLLGPVACHLLFYVMTLSGS 123
Cdd:cd14991     6 LLILEFVLGLPGNVVALWIFCFHSRTwKANTVYLFNLVLADFLLLICLPFRIDYYLRgEHWIFGEAWCRVNLFMLSVNRS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 124 VTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVffrvvpQRLPGADQEISICT--LIWPTI 201
Cdd:cd14991    86 ASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLL------STLLTVNSNKSSCHsfSSYTKP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 202 PGEISWDVSFVTLNFLVPGLVIVISYSKILQITkasRKRLtvslaySESHQIRVSqqdfRLFRTLFLLMVSFFIMWSPII 281
Cdd:cd14991   160 SLSIRWHNALFLLEFFLPLGLIVFCSVRIACNL---RIRQ------SLGKQARVQ----RAIRLVFLVVIVFVLCFLPSI 226
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1835884573 282 ITILLILIQNFKQDLVIWPS---LFFWVVAFTFANSALNPILY 321
Cdd:cd14991   227 IAGLLALVFKNLGSCRCLNSvaqLFHISLAFTYLNSALDPVIY 269
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
41-240 1.69e-07

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 52.10  E-value: 1.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  41 AVETTVLVLIFAVSLLGN-VCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMT 119
Cdd:cd14975     1 VLGCTLLSLAFAIGLPGNsFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFLATGTWDFGLAACKGCVYVCA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 120 LSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVpqrlpgADQEISICTLIWP 199
Cdd:cd14975    81 VSMYASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVE------ETVENGMCKYRHY 154
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1835884573 200 TIPGEISWDVSFVTLNFLVPGLVIVISYSKIL----QITKASRKR 240
Cdd:cd14975   155 SDGQLVFHLLLETVVGFAVPFTAVVLCYSCLLrrlrRRRFRRRRR 199
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
44-321 1.82e-07

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 51.92  E-value: 1.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCALVLVA-RRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSG 122
Cdd:cd15090     4 MALYSIVCVVGLFGNFLVMYVIVrYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNM 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 123 SVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVpqrlpgADQEISICTLIW--PT 200
Cdd:cd15090    84 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTK------YRQGSIDCTLTFshPS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 201 IPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRkrlTVSLAYSESHQIRvsqqdfRLFRTLFLLMVSFFIMWSPI 280
Cdd:cd15090   158 WYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVR---MLSGSKEKDRNLR------RITRMVLVVVAVFIVCWTPI 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1835884573 281 IITILLILIQNFKQDLVIWPSLFFwVVAFTFANSALNPILY 321
Cdd:cd15090   229 HIYVIIKALVTIPETTFQTVSWHF-CIALGYTNSCLNPVLY 268
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
49-292 2.06e-07

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 51.80  E-value: 2.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  49 LIFAVSLLGNVCALVLVAR-RRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLL--FYVMTLSGSVT 125
Cdd:cd15183     9 LVFIIGVVGNVLVVLVLIQhKRLRNMTSIYLFNLAISDLVFLFTLPFWIDYKLKDDWIFGDAMCKFLsgFYYLGLYSEIF 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 126 ILTLaaVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRvvpqrlpgADQEIS--ICTLIWPTIPG 203
Cdd:cd15183    89 FIIL--LTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLYFFK--------SQWEFThhTCSAHFPRKSL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 204 EISWDVSFVTLNFL---VPGLVIVISYSKILQITKAsrkrltvslayseshqiRVSQQDFRLFRTLFLLMVSFFIMWSPI 280
Cdd:cd15183   159 IRWKRFQALKLNLLgliLPLLVMIICYTGIINILLR-----------------RPNEKKAKAVRLIFVITLLFFLLWTPY 221
                         250
                  ....*....|..
gi 1835884573 281 IITILLILIQNF 292
Cdd:cd15183   222 NLAAFVSAFQDV 233
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
73-321 2.29e-07

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 51.45  E-value: 2.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  73 ATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRgpGR 152
Cdd:cd15970    34 ATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGSLLCRLVLSVDAINMFTSIYCLTVLSIDRYIAVVHPIKAAR--YR 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 153 R---ARAVLLAlIWGYSAVAALPLCVFFRVVPQrlpgADQEISiCTLIWPTipGEISWDVSFVTLNFLVPGL--VIVISY 227
Cdd:cd15970   112 RptvAKMVNLG-VWVFSILVILPIIIFSNTAPN----SDGSVA-CNMQMPE--PSQRWLAVFVVYTFLMGFLlpVIAICL 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 228 SKILQITKasrkrLTVSLAYSESHQIRVSQQDFrlfrTLFLLMV--SFFIMWSPIIITILLILIQNFKQDLVIWPSlffw 305
Cdd:cd15970   184 CYILIIVK-----MRVVALKAGWQQRKRSERKI----TLMVMMVvtVFVICWMPFYVVQLVSVFVGQHDATVSQLS---- 250
                         250
                  ....*....|....*.
gi 1835884573 306 vVAFTFANSALNPILY 321
Cdd:cd15970   251 -VILGYANSCANPILY 265
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
46-321 2.58e-07

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 51.38  E-value: 2.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  46 VLVLIFAVSLLGN--VCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACH---LLFYVMTL 120
Cdd:cd15404     6 VMIFILLVSFLGNfvVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRvsaMFFWLFVM 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 121 SGSVTILTlaaVSLERMVCIVhlQRGVRGPGRRARaVLLALIWGYSAVAALPLCVFFRVVpQRLPGADQeisiCTLIWPT 200
Cdd:cd15404    86 EGVAILLI---ISIDRFLIIV--QKQDKLNPYRAK-VLIAVSWAVSFCVAFPLAVGSPDL-QIPSRAPQ----CVFGYTT 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 201 IPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLtvslayseshqirvsqqdfrlFRTLFLLMVSFFIMWSPI 280
Cdd:cd15404   155 NPGYQAYVILIMLIFFFIPFMVMLYSFMGILNTVRSFKTRA---------------------FTTILILFIVFTVCWAPF 213
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1835884573 281 IITILLIliqNFKQDLVIWPSLF---FWVVAFTFANSALNPILY 321
Cdd:cd15404   214 TTYSLVA---TFNSHFYHKHNFFeisTWLLWLCYLKSALNPLIY 254
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
49-321 2.80e-07

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 51.25  E-value: 2.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  49 LIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIP-LVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTIL 127
Cdd:cd15114     9 VVFLVGVPGNALVAWVTGFEAKRSVNAVWFLNLAVADLLCCLSLPiLAVPIAQDGHWPFGAAACKLLPSLILLNMYASVL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 128 TLAAVSLERmvCIVHLQRGVRGPGRRARAV--LLALIWGYSAVAALPLCVFFRVVPQRLPgadqEISICTLIWpTIPGEI 205
Cdd:cd15114    89 LLTAISADR--CLLVLRPVWCQNHRRARLAwiACGAAWLLALLLTVPSFIYRRIHQEHFP----EKTVCVVDY-GGSTGV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 206 SWDVSFV--TLNFLVPGLVIVISYSKILQITKASRKrltvslayseshqirvsQQDFRLFRTLFLLMVSFFIMWSPI--- 280
Cdd:cd15114   162 EWAVAIIrfLLGFLGPLVVIASCHGVLLVRTWSRRR-----------------QKSRRTLKVVTAVVVGFFLCWTPYhvv 224
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1835884573 281 -IITILLILIQNFKQDLVIWPSLffwVVAFTFANSALNPILY 321
Cdd:cd15114   225 gLIIAASAPNSRLLANALKADPL---TVSLAYINSCLNPIIY 263
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
44-323 2.90e-07

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 51.34  E-value: 2.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVL-NLFCADLLFISAIPLVLAVRW-TEAWLLGPVACHLLFYVMTLS 121
Cdd:cd15132     4 TIVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLsSMAVSDLLILLCLPFDLYRLWkSRPWIFGEFLCRLYHYISEGC 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 122 GSVTILTLAAVSLERMVCIVH-LQRGVRGPGRRARAVLLALiWGYSAVAALPLcvFFRVVPQRLPG-------------- 186
Cdd:cd15132    84 TYATILHITALSIERYLAICFpLRAKVLVTRRRVKCVIAAL-WAFALLSAGPF--LFLVGVEQDNNihpddfsreckhtp 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 187 -ADQEISICTLIWPTipgeiswdvsfvTLNFLVPGLVIVISYSKILQITKASRKRLT--VSLAYSESHQIRVsqqdfrlf 263
Cdd:cd15132   161 yAVSSGLLGIMIWVT------------TTYFFLPMLCLSFLYGFIGRKLWKSKNDLRgpNAAARERSHRQTV-------- 220
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1835884573 264 RTLFLLMVSFFIMWSPIIITILLILiqNFKQDLVIWPSLFFWVVAFT--FANSALNPILYNM 323
Cdd:cd15132   221 RILAVVVLAFIICWLPFHIGRILFA--NTEDYRTMMFSQYFNIVAMQlfYLSASINPILYNL 280
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
46-176 3.02e-07

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 51.12  E-value: 3.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  46 VLVLIFAVSLLGN-VCALVLVARRRRRGATACLVLNLFCADLLFISAIPLvLAVRWTEAWLLGPVACHLLFYVMTLSGSV 124
Cdd:cd15178     6 IYVLVFLLSLPGNsLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPF-WAVSVVKGWIFGTFMCKLVSLLQEANFYS 84
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1835884573 125 TILTLAAVSLERMVCIVHLQRGVRGPgRRARAVLLALIWGYSAVAALPLCVF 176
Cdd:cd15178    85 GILLLACISVDRYLAIVHATRALTQK-RHLVKFVCAGVWLLSLLLSLPALLN 135
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
74-321 3.85e-07

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 50.92  E-value: 3.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLFISAIPLvLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRR 153
Cdd:cd15173    35 TDIFLVNLAVADLLFLCTLPF-WAYSAAHEWIFGTVMCKITNGLYTINLYSSMLILTCITVDRFIVIVQATKAHNCHAKK 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 154 AR--AVLLALIWGYSAVAALPLCVFFRVvpqrlpgADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKIL 231
Cdd:cd15173   114 MRwgKVVCTLVWVISLLLSLPQFIYSEV-------RNLSSKICSMVYPPDAIEVVVNIIQMTVGFFLPLLAMIICYSVII 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 232 qitkasrKRLTVSLAYseshqirvsqQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTF 311
Cdd:cd15173   187 -------KTLLHAKGF----------QKHKSLKIIFVVVAVFILTQLPYNIMKLIRTLHIENTDSTNFKYAILITEAIAY 249
                         250
                  ....*....|
gi 1835884573 312 ANSALNPILY 321
Cdd:cd15173   250 LHACLNPILY 259
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
41-323 3.98e-07

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 50.92  E-value: 3.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  41 AVETTVLVLIFAVSLLGNVCALVLVAR-RRRRGATACLVLNLFCADLL-FISAIPLVLAVRWT-EAWLLGPVACHLLFYV 117
Cdd:cd15212     1 AAQALVLLAIFLLSSLGNCAVIGVIVKhRQLRTVTNAFILSLSLSDLLtALLCLPFAFLTLFSrPGWLFGDRLCLANGFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 118 MTLSGSVTILTLAAVSLERMVCIVHLQRGvrGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEiSICTLI 197
Cdd:cd15212    81 NACFGIVSTLTMTLISFDRYYAIVRQPQG--KIGRRRALQLLAAAWLTALGFSLPWYLLASAPEYYEKLGFYH-CLYVLH 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 198 WPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTVSLAYseSHQIRVSQQdFRLFRTLFLLMVSFFIMW 277
Cdd:cd15212   158 SGPSRLGAAYSSVLIVLCYLLPFALMCFCHYNICKTVRLSESRVRPVTTY--AHLLRFYSE-MRTATTVLIMIVFIICCW 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1835884573 278 SPIIITILLILIqnfkQDLVIWPSLFFWVVAFTFANSALNPILYNM 323
Cdd:cd15212   235 GPYCLLGLVAAA----GGYQFPPLMDTVAIWMAWANGAINPLIYAI 276
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
42-321 4.46e-07

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 50.86  E-value: 4.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  42 VETTVLVLIFAVSLLGNVCALVLVARRRRRGATA-CLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMT 119
Cdd:cd15195     2 VRVLVTWVLFVISAAGNLTVLIQLFRRRRAKSHIqILIMHLALADLMVtFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQ 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 120 LSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLAliWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWP 199
Cdd:cd15195    82 FGMYLSSFMLVVIALDRVFAILSPLSANQARKRVKIMLTVA--WVLSALCSIPQSFIFSVLRKMPEQPGFHQCVDFGSAP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 200 TIPGEISWDVSFVTLNFLVPGLVIVISYSKIL----QITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLmvSFFI 275
Cdd:cd15195   160 TKKQERLYYFFTMILSFVIPLIITVTCYLLILfeisKMAKRARDTPISNRRRSRTNSLERARMRTLRMTALIVL--TFIV 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1835884573 276 MWSPIIITILLILiqnFKQDLVIW--PSLFFWVVAFTFANSALNPILY 321
Cdd:cd15195   238 CWGPYYVLGLWYW---FDKESIKNlpPALSHIMFLLGYLNPCLHPIIY 282
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
45-327 5.17e-07

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 50.54  E-value: 5.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGNVCALVLVAR-RRRRGATACLVLNLFCADLL-FISAIPLVLAVRWTE-AWLLGPVACH---LLFYVM 118
Cdd:cd15358     5 VTYLLIFVVGAVGNGLTCIVILRhKVMRTPTNYYLFSLAVSDLLvLLLGMPLELYEMWSNyPFLLGAGGCYfktLLFETV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 119 TLSgsvTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGAD--QEISICTL 196
Cdd:cd15358    85 CFA---SILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPNTSLHGIFQLTVPCRGpvPDSATCML 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 197 IWPTIPGEISWDVSFVtLNFLVPGLVIVISYSKI-LQITKasRKRLTV-----SLAYSESHQIRVSQQDFR---LFRTLF 267
Cdd:cd15358   162 VKPRWMYNLIIQITTL-LFFFLPMGTISVLYLLIgLQLKR--EKMLLVleakgSKAGDSYQHRRIQQEKRRrrqVTKMLF 238
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1835884573 268 LLMVSFFIMWSPiiitilliliqnFKQDLVIWPSLFFWVVA--------------FTFANSALNPILYNMTLCR 327
Cdd:cd15358   239 VLVVVFGICWAP------------FHTDRLMWSFISQWTGElhlafqyvhiisgvFFYLSSAANPVLYNLMSTR 300
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
77-321 5.42e-07

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 50.63  E-value: 5.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLFISAIPL-VLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRAR 155
Cdd:cd15194    38 FISNLAASDFIFLVTLPLwVDKEVVLGPWRSGSFLCKGSSYIISVNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 156 AVLLALIWGYSAVAALPlcvffrVVPQRLPGADQEISICTLIWPTiPGEISWDVSFVTLNFLVPGLVIVISYSKILqitk 235
Cdd:cd15194   118 KVCCTCVWMLSCLLGLP------TLLSRELKKYEEKEYCNEDAGT-PSKVIFSLVSLIVAFFLPLLSILTCYCTII---- 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 236 asrKRLTVSLAYSESHQIRVSqqdfRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWV-----VAFT 310
Cdd:cd15194   187 ---WKLCHHYQKSGKHQKKLR----KSIKIVFIVVAAFVFSWMPFNLFKALAIASGLQVEVTCLPYTLAQLgmevsAPLA 259
                         250
                  ....*....|.
gi 1835884573 311 FANSALNPILY 321
Cdd:cd15194   260 FANSCANPFIY 270
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
46-240 5.63e-07

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 50.52  E-value: 5.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  46 VLVLIFAVSLLGN-VCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWT-EAWLLGPVACHLLFYVMTLSGS 123
Cdd:cd15162     6 VYTLVFVVGLPANgMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHgNNWIFGEALCRLVTVAFYGNMY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 124 VTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVpqRLPGADqeISICTLIWPTIPG 203
Cdd:cd15162    86 CSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTI--FLPALD--ITTCHDVLPEQLL 161
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1835884573 204 EISWDVSFVTLN---FLVPGLVIVISYSKILQITKASRKR 240
Cdd:cd15162   162 VGDWFYYFLSLAivgFLIPFILTASCYVATIRTLAALEDE 201
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
80-321 6.46e-07

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 50.18  E-value: 6.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  80 NLFCADLLFISAIPLVLAVRWTE-AWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVL 158
Cdd:cd15380    41 NLAASDLVFVLGLPFWAENIRNQfNWPFGNFLCRVISGVIKANLFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVI 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 159 LALIWGYSAVAALPLCVFFRVvpQRLPgaDQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKIL----QIT 234
Cdd:cd15380   121 CLLIWVFGGLLSIPTFLFRSV--KHVP--DLNISACILLFPHEAWHFARRVELNIVGFLLPLAAIVFFNFHIIaslrERT 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 235 KASRKRLTvslayseshqirvSQQDFRLFRTLFLLMVSFFIMWSPIiitilliliqnfkqDLVIWPSLFFWVVA------ 308
Cdd:cd15380   197 EESRKRCG-------------GLKDTKATRLILTLVLMFLVCWTPY--------------HFFAFLDFLFQVEViqgcfw 249
                         250       260
                  ....*....|....*....|....*.
gi 1835884573 309 -------------FTFANSALNPILY 321
Cdd:cd15380   250 eefidlglqlanfFAFANSCLNPVIY 275
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
73-321 7.09e-07

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 50.12  E-value: 7.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  73 ATACLVLNLFCADL-LFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGvRGPG 151
Cdd:cd15073    34 PTNALIINLAVTDLgVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLLTVVAVDRYLTICRPDLG-RKMT 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 152 RRARAVLLALIWGYSAV-AALPLCVFFRVVPqrlpgaDQEISICTLIWPTIPGE-ISWDVSFVTLNFLVPGLVIVISYSK 229
Cdd:cd15073   113 TNTYTVMILLAWTNAFFwAAMPLVGWASYAL------DPTGATCTINWRKNDSSfVSYTMSVIVVNFIVPLAVMFYCYYN 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 230 ILQ-ITKASRKRLTVSLAYSESHQIRVSqqdfrlfRTLFLLMVSFFIMWSPIIITILLILIQNFKQdlvIWPslFFWVVA 308
Cdd:cd15073   187 VSRfVKKVLASDCLESVNIDWTDQNDVT-------KMSVIMIVMFLVAWSPYSIVCLWASFGEPKK---IPP--WMAIIP 254
                         250
                  ....*....|....*
gi 1835884573 309 FTFANSA--LNPILY 321
Cdd:cd15073   255 PLFAKSStfYNPCIY 269
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
46-323 7.50e-07

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 49.94  E-value: 7.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  46 VLVLIFAVSLLGNVCALVLVARRRRRGATACLVL-NLFCADLLFIS-AIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGS 123
Cdd:cd15323     6 VVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLvSLASADILVATlVMPFSLANELMGYWYFGQVWCNIYLALDVLFCT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 124 VTILTLAAVSLERMVCIVH-LQRGVRGPGRRARAVLLAlIWGYSAVAALPLCVFFRVVPQrlpgaDQEISICTLiwptip 202
Cdd:cd15323    86 SSIVHLCAISLDRYWSVTQaVEYNLKRTPRRVKAIIVT-VWLISAVISFPPLISMYRDPE-----GDVYPQCKL------ 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 203 GEISWDVSFVTL-NFLVPGLVIVISYSKILQITKASRKRLTVSLAyseshqirvsqqdfrlfrtlfLLMVSFFIMWSPII 281
Cdd:cd15323   154 NDETWYILSSCIgSFFAPCLIMILVYIRIYRVAKAREKRFTFVLA---------------------VVMGVFVVCWFPFF 212
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1835884573 282 ITILLILIqnFKQDLVIWPSLFFWVVAFTFANSALNPILYNM 323
Cdd:cd15323   213 FSYSLYGI--CREACEVPEPLFKFFFWIGYCNSSLNPVIYTI 252
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
42-196 8.51e-07

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 49.90  E-value: 8.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  42 VETTVLVLIFAVSLLGN-VCALVLVARRRRRGATACLVLNLFCADLLFI-SAIPLVLAVRWTEAWLLGPVACHLLFYVMT 119
Cdd:cd15977     2 VNTILSCVIFLVGIIGNsTLLRIIYKNKCMRNGPNVLIASLALGDLLYIlIAIPINVIKLIAEDWPFGVHVCKLYPFIQK 81
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1835884573 120 LSGSVTILTLAAVSLERMVCIVHLQRgVRGPGRRAR-AVLLALIWGYSAVAALPLCVFFRVVpqRLPGADQEISICTL 196
Cdd:cd15977    82 ASVGITVLSLCALSIDRYRAVASWSR-IRGIGIPVWkAVEVTLIWAVAIIVAVPEAIAFDMV--EIDYRGQTLLVCML 156
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
72-321 8.66e-07

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 49.68  E-value: 8.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  72 GATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGP-VACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGP 150
Cdd:cd15104    33 TKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQkVLCLLRMCFVITSCAASVLSLAAIAFDRYLALKQPLRYKQIM 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 151 GRRARAVLLALIWGYSA-VAALPLcVFFRVVPQRLPGadqeisICTLIWPTIPgEISWDVSFVTlnFLVPGLVIVISYSK 229
Cdd:cd15104   113 TGKSAGALIAGLWLYSGlIGFLPL-ISPQFQQTSYKG------KCSFFAAFHP-RVLLVLSCMV--FFPALLLFVFCYCD 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 230 ILQITKASRKRL-TVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPiiiTILLILIQNFKQDLVIWPSLFFWVVA 308
Cdd:cd15104   183 ILKIARVHSRAIyKVEHALARQIHPRRTLSDFKAARTVAVLIGCFLLSWLP---FQITGLVQALCDECKLYDVLEDYLWL 259
                         250
                  ....*....|...
gi 1835884573 309 FTFANSALNPILY 321
Cdd:cd15104   260 LGLCNSLLNPWIY 272
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-318 8.86e-07

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 49.95  E-value: 8.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGNVCALVLVARRRRRGATACLVL-NLFCAD-LLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSG 122
Cdd:cd15125     5 SLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFIsSLAAGDlLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQLTSV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 123 SVTILTLAAVSLERMVCIVHlQRGVRGPGRRARAVLLAL-IWGYSAVAALPLCVFFRVVpQRLPGADQEISICtliwptI 201
Cdd:cd15125    85 GVSVFTLTALSADRYKAIVN-PMDIQTSSAVLRTCLKAIaIWVVSVLLAVPEAVFSEVA-HIMPDDNTTFTAC------I 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 202 PGEISWD-------VSFVTLNFLVPGLVIVISYSKILQITKASRKRLTVSlaYSEsHQIRVSQQDFRLFRTLFLLMVSFF 274
Cdd:cd15125   157 PYPQTDEmhpkihsVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNIPGE--YSE-HSKRQMETRKRLAKIVLVFVGLFA 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1835884573 275 IMWSPIIITILLILIqNFKQdlvIWPSLFFWVVA-----FTFANSALNP 318
Cdd:cd15125   234 FCWFPNHVLYMYRSF-NYNE---IDSSLGHMIVTlvarvLSFCNSCVNP 278
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
46-334 9.20e-07

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 49.76  E-value: 9.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  46 VLVLIFAVSLLGNVCALVLVARRRRRGA-TACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGS 123
Cdd:cd15058     6 LLALIILAIVVGNLLVIIAIARTSRLQTmTNIFITSLACADLVMgLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 124 VTILTLAAVSLERMVCIVH-LQRGVRGPGRRARaVLLALIWGYSA-VAALPLCV-FFRVVPQRLPGADQEISICTLIWPT 200
Cdd:cd15058    86 ASIETLCVIAVDRYIAITRpLRYQVLLTKRRAR-VIVCVVWIVSAlVSFVPIMNqWWRANDPEANDCYQDPTCCDFRTNM 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 201 IPGEISWDVSfvtlnFLVPGLVIVISYSKILQITKASRKRL---------------TVSLAYSESHQIRVSQ----QDFR 261
Cdd:cd15058   165 AYAIASSVVS-----FYIPLLIMIFVYARVFLIATRQLQLIdkrrlrfqsecpapqTTSPEGKRSSGRRPSRltvvKEHK 239
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1835884573 262 LFRTLFLLMVSFFIMWSPiiiTILLILIQNFKQDLVIWPsLFFWVVAFTFANSALNPILYnmtlCRN-EWKKIF 334
Cdd:cd15058   240 ALKTLGIIMGTFTLCWLP---FFIANIINVFNRNLPPGE-VFLLLNWLGYINSGLNPIIY----CRSpEFRTAF 305
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
74-321 1.25e-06

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 49.35  E-value: 1.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRR 153
Cdd:cd15087    35 TNVFILNLAIADDLFTLVLPINIAEHLLQQWPFGELLCKLILSIDHYNIFSSIYFLTVMSVDRYLVVLATVRSRRMPYRT 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 154 ARAVLLA--LIWGYSAVAALPLCVFFRVVpqrlpGADQEISICTLIWPTiPGEISWDVSFV---TLNFLVPGLVIVISYS 228
Cdd:cd15087   115 YRAAKIVslCVWLLVTIIVLPFTVFAGVY-----SNELGRKSCVLSFPS-PESLWFKASRIytlVLGFAIPVSTICILYT 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 229 KILQitKASRKRLTVSLAYSESHQIRVSqqdfrlFRTLFLLMVSFFImWSPIIITILLILIQNFKQD-LVIWPSLFfwVV 307
Cdd:cd15087   189 MMLY--KLRNMRLNSNAKALDKAKKKVT------LMVLVVLAVCLFC-WTPFHLSTVVALTTDLPQTpLVIGISYF--IT 257
                         250
                  ....*....|....
gi 1835884573 308 AFTFANSALNPILY 321
Cdd:cd15087   258 SLSYANSCLNPFLY 271
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
214-321 1.29e-06

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 49.47  E-value: 1.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 214 LNFLVPGLVIVISYSKILQITKASRKRLTVS----LAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILI 289
Cdd:cd15316   172 LLFFIPTFAMIILYGKIFLVAKQQARKIEMTsskaESSSESYKDRVARRERKAAKTLGITVIAFLVSWLPYLIDVLIDAF 251
                          90       100       110
                  ....*....|....*....|....*....|..
gi 1835884573 290 QNFkqdlVIWPSLFFWVVAFTFANSALNPILY 321
Cdd:cd15316   252 MNF----ITPPYIYEICCWCAYYNSAMNPLIY 279
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
43-321 1.34e-06

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 49.35  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  43 ETTVLVLIFAVSLLGNVCALVLVARRRRRGA-TACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVA-CHLLFYVMTL 120
Cdd:cd14964     1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRsTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQAlCYLIYLLWYG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 121 SGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFfrvvpqrlPGADQEISICTLIWPT 200
Cdd:cd14964    81 ANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVG--------KGAIPRYNTLTGSCYL 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 201 IPGEISWDVSFVTLNFLVPGLVIVISYSKIlqitkasRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPI 280
Cdd:cd14964   153 ICTTIYLTWGFLLVSFLLPLVAFLVIFSRI-------VLRLRRRVRAIRSAASLNTDKNLKATKSLLILVITFLLCWLPF 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1835884573 281 IITILLILIQNFKQDLVIWPSLFFWvvaFTFANSALNPILY 321
Cdd:cd14964   226 SIVFILHALVAAGQGLNLLSILANL---LAVLASTLNPFIY 263
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
45-173 1.34e-06

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 49.42  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGN-VCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEA-WLLGPVACHLLFYVMTLSG 122
Cdd:cd15921     5 TAYILIFILGLTGNsISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNShWPFGDIACRIILYVLYVNM 84
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1835884573 123 SVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPL 173
Cdd:cd15921    85 YSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPL 135
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
77-332 1.72e-06

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 49.12  E-value: 1.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLFISAIPLVLAVRWTE-AWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRAR 155
Cdd:cd15926    39 FVTSLAVTDFQFVLTLPFWAVENALDfTWLFGKAMCKIVSYVTAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSA 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 156 AVLLALIWGYSAVAALPLCVFFRVVPQrlpgADQEisICTLIWPTIPGEIS-----WDVSFVTLNFLVPGLVIVISYskI 230
Cdd:cd15926   119 KWLCVLIWVLAILASLPNAIFSTTATV----SNEE--LCLVKFPDNRGNAQfwlglYHAQKVLLGFLIPLGIISLCY--L 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 231 LQITKASRKRLTVSLAYSEShqirvsqqdfRLFRTLFLLMVSFFIMWSPIIITILLILIqnFKQDLVIWPSLFFWVVAFT 310
Cdd:cd15926   191 LLVRFITDKNITGSSTKRRS----------KVTKSVTIVVLSFFLCWLPNQALTTWGIL--IKLNVVHFSYEYFTTQVYI 258
                         250       260       270
                  ....*....|....*....|....*....|
gi 1835884573 311 F--------ANSALNPILYnmTLCRNEWKK 332
Cdd:cd15926   259 FpitvclahSNSCLNPILY--CLMRREFRK 286
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
76-321 1.75e-06

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 48.83  E-value: 1.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  76 CLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRAR 155
Cdd:cd14972    35 ILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLASAYSLLAIAVDRYISIVHGLTYVNNVTNKRV 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 156 AVLLALIWgysavaalPLCVFFRVVPqrLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITK 235
Cdd:cd14972   115 KVLIALVW--------VWSVLLALLP--VLGWNCVLCDQESCSPLGPGLPKSYLVLILVFFFIALVIIVFLYVRIFWCLW 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 236 asrKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLviwPSLFFWVVAFTFANSA 315
Cdd:cd14972   185 ---RHANAIAARQEAAVPAQPSTSRKLAKTVVIVLGVFLVCWLPLLILLVLDVLCPSVCDI---QAVFYYFLVLALLNSA 258

                  ....*.
gi 1835884573 316 LNPILY 321
Cdd:cd14972   259 INPIIY 264
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
49-279 1.78e-06

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 48.92  E-value: 1.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  49 LIFAVSLLGNVCALVLVARR-RRRGATACLVLNLFCADLLFISAIPLvLAVRWTEAWLLGPVACHLLFYVMTLSGSVTIL 127
Cdd:cd15180     9 LVFLLGLLGNGLVLAVLLQKrRNLSVTDTFILHLALADILLLVTLPF-WAVQAVHGWIFGTGLCKLAGAVFKINFYCGIF 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 128 TLAAVSLERMVCIVH-LQRGVRGPGRRARAVLLaLIWGYSAVAALPLCVFFRVVPQRlpgaDQEISICTLIWP--TIPGE 204
Cdd:cd15180    88 LLACISFDRYLSIVHaVQMYSRKKPMLVHLSCL-IVWLFCLLLSIPDFIFLEATKDP----RQNKTECVHNFPqsDTYWW 162
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1835884573 205 ISWDVSFVTLNFLVPGLVIVISYSKILqitkasrKRLTVSlayseSHQirvsQQDFRLFRTLFLLMVSFFIMWSP 279
Cdd:cd15180   163 LALRLLYHIVGFLLPLAVMVYCYTSIL-------LRLLRS-----SQG----FQKQRAIRVIVAVVVVFFLCWTP 221
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
46-334 2.43e-06

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 48.33  E-value: 2.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  46 VLVLIFAVSLLGNVCALVLVARRRRRGATACLVL-NLFCADLLFIS-AIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGS 123
Cdd:cd15324     6 VVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLvSLASADILVATlVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 124 VTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPlcvffrvvPQRLPGADQeisictliWPTIPG 203
Cdd:cd15324    86 SSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFP--------PLLMTKHDE--------WECLLN 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 204 EISWDV-SFVTLNFLVPGLVIVISYSKILQITKASRKRLTVSLAyseshqirvsqqdfrlfrtlfLLMVSFFIMWSPIII 282
Cdd:cd15324   150 DETWYIlSSCTVSFFAPGLIMILVYCKIYRVAKMREKRFTFVLA---------------------VVMGVFVLCWFPFFF 208
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1835884573 283 TILLILIqnFKQDLVIWPSLFFWVVAFTFANSALNPILYnmTLCRNEWKKIF 334
Cdd:cd15324   209 TYSLHAV--CRKRCGIPDALFNLFFWIGYCNSSVNPIIY--TIFNRDFRKAF 256
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
74-321 2.71e-06

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 48.32  E-value: 2.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLF-ISAIPLVlAVRWTEA-WLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVH-LQRGVRGP 150
Cdd:cd15055    35 TNLLLLSLAVADFLVgLLVMPFS-MIRSIETcWYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDpLLYPTKIT 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 151 GRRArAVLLALIWGYSAVAALPLCVFFRVVPqrlpGADQEISiCtliwptiPGE------ISWDVSFVTLNFLVPGLVIV 224
Cdd:cd15055   114 IRRV-KICICLCWFVSALYSSVLLYDNLNQP----GLIRYNS-C-------YGEcvvvvnFIWGVVDLVLTFILPCTVMI 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 225 ISYSKILQITKASRKR---LTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILliliqnFKQDLVIWPS 301
Cdd:cd15055   181 VLYMRIFVVARSQARAirsHTAQVSLEGSSKKVSKKSERKAAKTLGIVVGVFLLCWLPYYIVSL------VDPYISTPSS 254
                         250       260
                  ....*....|....*....|
gi 1835884573 302 LFFWVVAFTFANSALNPILY 321
Cdd:cd15055   255 VFDVLIWLGYFNSCLNPLIY 274
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
41-321 3.04e-06

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 48.34  E-value: 3.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  41 AVETTVLVLIFAVSLLGN-VCALVLVARRRRRGATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVM 118
Cdd:cd15980     1 AVFIASYLLIFLLCMMGNgVVCFIVLRSKHMRTVTNLFILNLAISDLLVgIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 119 TLSGSVTILTLAAVSLERMVCIVHLQRgvRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQ-----RLPGADQEISI 193
Cdd:cd15980    81 GISVSASVFTLVAIAVDRFRCIVYPFK--QKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEknyrvVLGSQNKTSPV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 194 --CTLIWPTiPG--EISWDVSFVTLnFLVPGLVIVISYSKI-LQITKASrkrLTVSLAYSESHQIRVSQQDFRLFRTLFL 268
Cdd:cd15980   159 ywCREDWPN-QEmrKIYTTVLFANI-YLAPLSLIVIMYARIgITLFKTA---MPHTGKHNQEQRHVVSRKKQKVIKMLLI 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1835884573 269 LMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVA--FTFANSALNPILY 321
Cdd:cd15980   234 VALLFILSWLPLWTLMMLSDYANLSPNQLQIINIYIYPFAhwLAFFNSSVNPIIY 288
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
48-227 3.13e-06

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 48.22  E-value: 3.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  48 VLIFAVSLLGNVCALVLVARRRRRG-ATACLVLNLFCADLLFISAIPL-VLAVRWTEAWLLGPVAC---HLLFYVmTLSG 122
Cdd:cd14987     8 IFIFVIGLLANSVVVWVNLQAKRTGyETHLYILNLAIADLCVVATLPVwVVSLVQHNQWPMGEFTCkitHLIFSI-NLFG 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 123 SVTILTlaAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGAdqeisicTLIWPTIP 202
Cdd:cd14987    87 SIFFLT--CMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPDTYFLKTVTSPSNNE-------TYCRSFYP 157
                         170       180       190
                  ....*....|....*....|....*....|.
gi 1835884573 203 GE------ISWDVSFVTLNFLVPGLVIVISY 227
Cdd:cd14987   158 EEsfkewlIGMELVSIVLGFVIPFPIIAVFY 188
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
49-232 3.34e-06

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 48.15  E-value: 3.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  49 LIFAVSLLGNVCALVLVARRRRRGATACLV-LNLFCADLLFISAIP-LVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTI 126
Cdd:cd15375     9 IIFIVGFPGNIIAIFVYLFKMRPWKSSTIImLNLALTDLLYVTSLPfLIYYYINGESWIFGEFMCKFIRFIFHFNLYGSI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 127 LTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQrlpgadQEISICTLIWPTIPGEIS 206
Cdd:cd15375    89 LFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAEVSPMTFLITTKEK------NNRTICLDFTSSDNLNTI 162
                         170       180
                  ....*....|....*....|....*...
gi 1835884573 207 WDVSFV--TLNFLVPGLVIVISYSKILQ 232
Cdd:cd15375   163 WWYNWIltVLGFLLPLVIVTLCYTRIIY 190
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
45-230 4.40e-06

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 47.76  E-value: 4.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGNVC-ALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTE-AWLLGPVACHL--LFYVMTL 120
Cdd:cd15967     5 PVYILVFVVGLVGNVWgLKSLLANWKKLGNINVFVLNLGLADLLYLLTLPFLVVYYLKGrKWIFGQVFCKItrFCFNLNL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 121 SGSVTILTlaAVSLERMVCIVHLQRgVRGPGRRARAVLL-ALIWGYSAVAALPLCVFFRVVPQRLPGADqeisicTLIWP 199
Cdd:cd15967    85 YGSIGFLT--CISVYRYLAIVHPMR-VMGRITTTHSVVIsALVWLLVVIQSLPDLFFSKTNSNGTKCFD------TTFND 155
                         170       180       190
                  ....*....|....*....|....*....|.
gi 1835884573 200 TIPGEISWDVSFVTLNFLVPGLVIVISYSKI 230
Cdd:cd15967   156 YLESYLTYSLGWTVTGFVIPLLIILGCYGHV 186
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
77-334 4.54e-06

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 47.66  E-value: 4.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLfISAIPLVLAVRW--TEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVH--LQRGVRGPgR 152
Cdd:cd17790    38 FLLSLACADLI-IGAFSMNLYTTYilMGHWALGTVACDLWLALDYVASNASVMNLLIISFDRYFSITRplTYRAKRTP-R 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 153 RArAVLLALIWGYSAVAALPLCVFFR-VVPQRLPGADQeisiCTLIWPTIPgEISWDVSFVTlnFLVPGLVIVISYSKIL 231
Cdd:cd17790   116 RA-AIMIGLAWLISFVLWAPAILFWQyLVGERTVLAGQ----CYIQFLSQP-IITFGTAIAA--FYLPVTIMIILYWRIY 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 232 QITKASRKRLtvslayseshqirvsqqdfrlfRTLFLLMVSFFIMWSPiiiTILLILIQNFKQDLV---IWpSLFFWVVa 308
Cdd:cd17790   188 RETIKEKKAA----------------------RTLSAILLAFILTWTP---YNIMVLVSTFCKDCVpktLW-ELGYWLC- 240
                         250       260
                  ....*....|....*....|....*.
gi 1835884573 309 ftFANSALNPILYnmTLCRNEWKKIF 334
Cdd:cd17790   241 --YVNSTVNPMCY--ALCNKSFRDTF 262
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
46-321 5.20e-06

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 47.42  E-value: 5.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  46 VLVLIFAVSLLGN--VCALVLVARRRRRGATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVA-CHLLFYVMTLS 121
Cdd:cd15057     6 ILYLLVLLTLLGNalVIAAVLRFRHLRSKVTNYFIVSLAVSDLLVaILVMPWAAVNEVAGYWPFGSFCdVWVSFDIMCST 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 122 GSvtILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSA-VAALPLCVFFRVVPQRLPGA--DQEISICTLIW 198
Cdd:cd15057    86 AS--ILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSAlISFIPVQLGWHRADDTSEALalYADPCQCDSSL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 199 PTIPGEISWDVSfvtlnFLVPGLVIVISYSKILQITK------ASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVS 272
Cdd:cd15057   164 NRTYAISSSLIS-----FYIPVAIMIVTYTRIYRIARrqirriAALERAAQESTNPDSSLRSSLRRETKALKTLSIIMGV 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1835884573 273 FFIMWSPIIITILLIL--IQNFKQDLVIWPSLFFWVVAFTFANSALNPILY 321
Cdd:cd15057   239 FVCCWLPFFILNCVLPfcDLRTAQFPCVPDTTFIVFVWLGWANSSLNPIIY 289
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
77-279 5.65e-06

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 47.40  E-value: 5.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRAR 155
Cdd:cd15336    38 FIINLAVSDFLMsLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITSMITLLAISLDRYLVITKPLASIRWVSKKRA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 156 AVLLALIWGYSAVAAL-PLCVFFRVVPQRLpgadqeISICTLIWPT-IPGEISWDVSFVTLNFLVPGLVIVISYSKILQI 233
Cdd:cd15336   118 MIIILLVWLYSLAWSLpPLFGWSAYVPEGL------LTSCTWDYMTfTPSVRAYTMLLFCFVFFIPLGIIIYCYLFIFLA 191
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1835884573 234 TKASRKRLT--VSLAYSESHQIRVS-QQDFRLFRTLFLLMVSFFIMWSP 279
Cdd:cd15336   192 IRSTGREVQklGSQDRKEKAKQYQRmKNEWKMAKIAFVVILLFVLSWSP 240
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
45-321 5.91e-06

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 47.09  E-value: 5.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGNVCALVLVARRRRRGAT-ACLVLNLFCADLLFISAIPLVLAVRWT-EAWLLGPVACHLLFYVMTLSG 122
Cdd:cd15199     5 SLLILEFGLGLPGNAIALWTFIFRLKVWKPyAVYLLNLVLADVLLLICLPFKAYFYLNgNRWSLGGGTCKALLFMLSLSR 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 123 SVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWgysaVAALPLCVFFRVVPQrlpgaDQEISICTLIWPTIP 202
Cdd:cd15199    85 GVSIAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVW----LLLVGLTIPTLLASQ-----PKNFTECNSFSPKDD 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 203 GEIS--WDVSFVTLNFLVPGLVIVISYSKILqitKASRKRLtvslayseshqiRVSQQDFRLFRTLFL---LMVSFFIMW 277
Cdd:cd15199   156 EDFSdtWQEAVFFLQFLLPFGLIVFCTVRII---RRLKKRL------------RDVGKQPKLQRAMALvtsVVVVFGFCF 220
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1835884573 278 SPIIIT-ILLILIQNFK--QDLVIWPSLFFWVVAFTFANSALNPILY 321
Cdd:cd15199   221 LPCFLArVLMLIFQNKEscNALNIAVHTYDVTMCLTYLNSVLDPIVY 267
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
79-321 6.06e-06

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 47.43  E-value: 6.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  79 LNLFCADLLFISAIPLVLAVRWTE-AWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAV 157
Cdd:cd15119    39 LNLAIADFVFVLFLPLHITYVALDfHWPFGVWLCKINSFVAVLNMFASVLFLTVISLDRYISLAHPVWSHRYRTLKSALI 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 158 LLALIWGYSAVAALPlCVFFR----------VVPQRLPGADQEISIC---TLIWptipgeiswdVSFVtLNFLVPGLVIV 224
Cdd:cd15119   119 LCGIVWLSAAAISGP-ALYFRdtmelsinvtICFNNFHKHDGDLIVMrhtILVW----------VRFF-FGFLFPLLTMV 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 225 ISYSkiLQITKASRKRLTVSlayseshqirvsqqdFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFF 304
Cdd:cd15119   187 VCYS--LLAIKVKRRTLLIS---------------SKFFWTISAVIVAFFVCWTPYHIFSILELSIHHSSYLHNVLRAGI 249
                         250
                  ....*....|....*...
gi 1835884573 305 -WVVAFTFANSALNPILY 321
Cdd:cd15119   250 pLATSLAFINSCLNPILY 267
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
44-324 6.22e-06

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 47.48  E-value: 6.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCALVLVARRRRRGATACLV----LNLFCADLL-FISAIPLVL-AVRWTE-AWLLGPVACHLLFY 116
Cdd:cd15135     4 TLLYSLILVAGILGNSATIKVTQVLQKKGYLQKSVtdhmVSLACSDLLvLLLGMPVELySAIWDPfATPSGNIACKIYNF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 117 VMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARaVLLALIWGYSAVAALPLCV------------FFRVVPQRL 184
Cdd:cd15135    84 LFEACSYATILNVATLSFERYIAICHPFKYKALSGSRVR-LLICFVWLTSALVALPLLFamgtedpleafpSYRGTRHHC 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 185 PGADQEISICTLI---WPTIPGEISwdVSFVTLnFLVPGLVIVISYSKILQITKASRKRLTVS--------LAYSESHQI 253
Cdd:cd15135   163 QDQKSNLTICTSLsskWTVFQASIF--SAFVLY-LLVLASVAFMCRRMMRALMGSKKGAVAVKgpggsvqlLRKHESAEG 239
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1835884573 254 RVSQQDFRLFrtLFLLMVSFFIMWSPIIITILLILIQNfKQDlviWPSLFFWVV--------AFTFANSALNPILYNMT 324
Cdd:cd15135   240 KTARKQTILF--LGLIVGTLAVCWMPNQIRRIMAAAKP-KDD---WTRSYFRAYiillpiadTFFYLSSVLNPLLYNLS 312
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
49-279 6.94e-06

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 47.04  E-value: 6.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  49 LIFAVSLLGNVCALVLVARRR-RRGATACLVLNLFCADLLfISAIPLVLAVRWT--EAWLLGPVACHLLFYVMTLSGSVT 125
Cdd:cd15397     9 LVMAVGLLGNICLICVIARQKeKTNVTNILIANLSFSDIL-VCLVCLPFTVVYTlmDYWIFGEVLCKMTPFIQCMSVTVS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 126 ILTLAAVSLERMVCIVHlQRGVRgPGRRARAVLLALIWGYSAVAALPLCVF-------FRVVPQRL-PGADQeiSICTLI 197
Cdd:cd15397    88 ILSLVLIALERHQLIIN-PTGWK-PSVSQAYLAVVVIWMLACFISLPFLAFhiltdepYKNLSHFFaPLADK--AVCTES 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 198 WPTIPGEISWDVSFVTLNFLVPGLVIVISYSKI-LQITKasRKRLtvsLAYSESHQIRVSQQDfRLFRTLFLLMVSFFIM 276
Cdd:cd15397   164 WPSEHHKLAYTTWLLLFQYCLPLLFILVCYLRIyLRLRR--RKDM---LERRGEYNRRAGHSK-RINVMLVSLVAAFALC 237

                  ...
gi 1835884573 277 WSP 279
Cdd:cd15397   238 WLP 240
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
42-321 7.16e-06

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 46.90  E-value: 7.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  42 VETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWT--EAWLLGPVACHLLFYVMT 119
Cdd:cd15330     2 ITSLFLGTLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQvlNKWTLGQVTCDLFIALDV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 120 LSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRlpgadQEISICTliwp 199
Cdd:cd15330    82 LCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWRTPEDR-----SDPDACT---- 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 200 tipgeISWDVSFVTLN----FLVPGLVIVISYSKILQitKASRKRLTVslayseshqirvsqqdfrlfRTLFLLMVSFFI 275
Cdd:cd15330   153 -----ISKDPGYTIYStfgaFYIPLILMLVLYGRIFK--AAARERKTV--------------------KTLGIIMGTFIL 205
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1835884573 276 MWSPIIITILLILiqnFKQDLVIWPSLFFWVVAFT-FANSALNPILY 321
Cdd:cd15330   206 CWLPFFIVALVLP---FCESTCHMPELLGAIINWLgYSNSLLNPIIY 249
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
74-321 9.46e-06

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 46.78  E-value: 9.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGR 152
Cdd:cd15318    35 TNFLLLSLALADMLLgLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTI 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 153 RARAVLLALIWGYSAVAAlPLCVFFRVVPQRLPGADQE---ISICTLIWPTIPGEISWDVsfvtlnFLVPGLVIVISYSK 229
Cdd:cd15318   115 RVACIFIAAGWLVPTVYT-SVFLYTKAVEEGLAELLTSvpcVGSCQLLYNKLWGWLNFPV------FFIPCLIMIGLYVK 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 230 ILQITKaSRKRLTVSLAYSEShqiRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFkqdlVIWPSLFFWVVAF 309
Cdd:cd15318   188 IFIVAK-RQARAIASLLSDTN---GASKRERKAAKTLGIAVGVYLLCWLPFTIDTMVDSLLNF----ITPPLLFDIIIWF 259
                         250
                  ....*....|..
gi 1835884573 310 TFANSALNPILY 321
Cdd:cd15318   260 AYFNSACNPLIY 271
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
44-323 9.48e-06

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 46.78  E-value: 9.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGN--VCALVLVARRRRRgATACLVLNLFCADLL-FISAIPLVLAVRWTE-AWLLGPVACHLLFYVMT 119
Cdd:cd15357     4 SLVYAVIFVVGVIGNllVCLVILKHQNMKT-PTNYYLFSLAVSDLLvLLFGMPLEVYEMWSNyPFLFGPVGCYFKTALFE 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 120 LSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGAD--QEISICTLI 197
Cdd:cd15357    83 TVCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIPNTSIHGIKLQYFPNGTliPDSATCTVV 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 198 WPTipgeisWDVSFVT-----LNFLVPGLVIVISYSKILQITKASRKRLTVSLAYSESHQIRVSqqdfrLFRTLFLLMVS 272
Cdd:cd15357   163 KPL------WIYNLIIqitslLFYVLPMGVISVLYYLMGLKLRGDKSLEADEMNVNIQRPSRKS-----VTKMLFVLVLV 231
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1835884573 273 FFIMWSPiiitilliliqnFKQDLVIWPSLFFW------------VVA--FTFANSALNPILYNM 323
Cdd:cd15357   232 FAICWAP------------FHVDRLFFSFVVEWteplanvfnlihVVSgvFFYLSSAVNPIIYNL 284
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
46-323 1.00e-05

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 46.75  E-value: 1.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  46 VLVLIFAVSLLGN--VCALVLVARRRRrGATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSG 122
Cdd:cd15008     5 VFGVLWLVSVFGNslVCLVIHRSRRTQ-STTNYFVVSMACADLLLsVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTP 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 123 SVTILTLAAVSLERMVCIVH-LQRGVrgpGRRARAVLLALIWGYSAVAALPLCVFFRVVPQrlpgadqeiSICTLIWPTI 201
Cdd:cd15008    84 GVQIYVLLSICVDRFYTIVYpLSFKV---SREKAKKMIAASWLFDAAFVSPALFFYGSNWG---------PHCNFFLPDS 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 202 PGEISWDVSFVTLNFLVPGLVIVISYSKILQ-ITKASRKRLTVSLAYSESHQIRVsqqdfRLFRTLFLLMVSFFIMWSPi 280
Cdd:cd15008   152 WDGAAYAIIHLLVGFLVPSILIILFYQKVIKyIWRIGTDGRTVRRTMNIVPRTKV-----KTIKMFLMLNSMFLLSWLP- 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1835884573 281 iiTILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNM 323
Cdd:cd15008   226 --FYVVQLWHPRESDYRQSSLVFLAVTWISFSSSASKPTLYSV 266
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
46-321 1.04e-05

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 46.54  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  46 VLVLIFAVSLLGNVCALVLVARRR-RRGATACLVLNLFCADLLFISAIPLVLAVRWTEA-WLLGPVACHLLFYVMTLSGS 123
Cdd:cd15168     6 VYGVVFLVGLLLNSVVLYRFIFHLkPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDhWIFGDFMCKLVRFLFYFNLY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 124 VTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRlpgadqeisICTLIWP-TIP 202
Cdd:cd15168    86 GSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKN---------NRTTCYDtTSP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 203 GEISWDVSF----VTLNFLVPGLVIVISYSKIL--------QITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLM 270
Cdd:cd15168   157 EELNDYVIYsmvlTGLGFLLPLLIILACYGLIVralirklgEGVTSALRRKSIRLVIIVLALFAVCFLPFHVTRTINLAA 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1835884573 271 VSFFIMWSPIIITILLILIQnfkqdlvIWPSLffwvvafTFANSALNPILY 321
Cdd:cd15168   237 RLLSGTASCATLNGIYVAYK-------VTRPL-------ASLNSCLNPLLY 273
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
49-239 1.06e-05

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 46.67  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  49 LIFAVSLLGNVCALVLVARRRRRGA-TACLVLNLFCADLLFISAIPLvLAVRWTEAWLLGPVACHLLFYVMTLSGSVTIL 127
Cdd:cd15174     9 LIFLVGAVGNSLVVLIYTYYRRRKTmTDVYLLNLAIADLLFLCTLPF-WATAASSGWVFGTFLCKVVNSMYKINFYSCML 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 128 TLAAVSLERMVCIVHLQRGVRGPGRRA--RAVLLALIWGYSAVAALPLCVFFRVvpqrlpGADQEISICTLIWPTIPGEI 205
Cdd:cd15174    88 LLTCISVDRYIAIVQATKAHNSKNKRLlySKLVCFFVWLLSTILSLPEILFSQS------KEEESVTTCTMVYPSNESNR 161
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1835884573 206 SWDVSF---VTLNFLVPGLVIVISYSKILQITKASRK 239
Cdd:cd15174   162 FKVAVLalkVTVGFFLPFVVMVICYTLIIHTLLQAKR 198
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
102-324 1.19e-05

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 46.40  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 102 EAWLlGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRgPGRRARAVLLALIW--GYsAVAALPLCvfFRV 179
Cdd:cd15965    72 QLWM-DSTQCQLVGSLAILSTEVSVLLLTYLTLEKYICIVYPFRCLT-PGKCRTITILILIWiiGF-IIAFIPLS--NKE 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 180 VPQRLPGADqeiSICTLIWP----TIPGEISWDVSFVTLNfLVPGLVIVISYSKILQITKAsrkrlTVSLAYSESHQIRv 255
Cdd:cd15965   147 FFRNYYGTN---GVCFPLHSeqpeSTGAQIYSVVIFLGLN-LAAFIIIVFSYGSMFYSIHQ-----TAIMATEISNHIK- 216
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 256 sqQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQnfkqdLVIWPSLFFWVVAFTFA-NSALNPILYNMT 324
Cdd:cd15965   217 --KEMTLAKRFFFIVFTDALCWIPIFILKLLSLLQ-----VEIPGTISSWVVIFILPiNSALNPILYTLT 279
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
104-321 1.43e-05

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 46.19  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 104 WLLGPVACH--LLFYVMTLSGSvtILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSA-VAALPLCV-FFRV 179
Cdd:cd15065    65 WLFGETFCNiwISFDVMCSTAS--ILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSAlISFLPIHLgWHRL 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 180 VPQRLPGADQEIS---ICTLIWPTIPGEISWDVSFVtlnflVPGLVIVISYSKILQITKASRKRL-----------TVSL 245
Cdd:cd15065   143 SQDEIKGLNHASNpkpSCALDLNPTYAVVSSLISFY-----IPCLVMLLIYSRLYLYARKHVVNIksqklpsesgsKFQV 217
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1835884573 246 AYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQnfkqDLVIWPSLFFWVVAFTFANSALNPILY 321
Cdd:cd15065   218 PSLSSKHNNQGVSDHKAAVTLGIIMGVFLICWLPFFIINIIAAFC----KTCIPPKCFKILTWLGYFNSCLNPIIY 289
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
74-323 1.50e-05

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 46.19  E-value: 1.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLFISAIPLVLAVRWTEA-WLLGPVACHLLFYV-MTLSgSVTILTLAAVSLERMVCIVHLQRGVRGPG 151
Cdd:cd15312    35 TNFLILSLAITDFLLGFLVMPYSMVRSVEScWYFGDLFCKIHSSLdMMLS-TTSIFHLCFIAVDRYYAVCDPLHYRTKIT 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 152 RRARAVLLALIWGYSAVAALPLcVFFRVvpqRLPGA-DQEISI-----CTLIWPTIpgeisWDVSFVTLNFLVPGLVIVI 225
Cdd:cd15312   114 TPVIKVFLVISWSVPCLFAFGV-VFSEV---NLEGIeDYVALVsctgsCVLIFNKL-----WGVIASLIAFFIPGTVMIG 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 226 SYSKILQITKASRKRL--TVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWpSLF 303
Cdd:cd15312   185 IYIKIFFVARKHAKVInnRPSVTKGDSKNKLSKKKERKAAKTLSIVMGVFLLCWLPFFVATLIDPFLNFSTPVDLF-DAL 263
                         250       260
                  ....*....|....*....|
gi 1835884573 304 FWvvaFTFANSALNPILYNM 323
Cdd:cd15312   264 VW---LGYFNSTCNPLIYGF 280
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
47-323 1.57e-05

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 45.91  E-value: 1.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  47 LVLIFAVSLLGNVCALVLVARRRRRGATACLVL-NLFCADLLFISAIPL-VLAVRWTEAWLLGPVACHLLFYVMTLSGSV 124
Cdd:cd15381     7 LWIIFVLGTIENAFVLIVFCLHKSSCTVAEIYLgNLAAADLLLVCCLPFwAINISNGFNWPFGEFLCKSVNAVIYMNLYS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 125 TILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVvpQRLPGADqeISICTLIWPTIPGE 204
Cdd:cd15381    87 SIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTV--MYFPEYN--ITACVLDYPSEGWH 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 205 ISWDVSFVTLNFLVPGLVIVISYSKILQItkasrkrltvsLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITI 284
Cdd:cd15381   163 VALNILLNVVGFLIPLSIITFCSTQIIQV-----------LRNNKMQKFKEIQTERKATVLVLAVLLMFFICWLPFHIFT 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1835884573 285 LLILIQNFK-------QDLVIWPSLFFWVVAFTfaNSALNPILYNM 323
Cdd:cd15381   232 FLDTLHKLGlisgcrwEDILDIGTQIATFLAYS--NSCLNPLLYVI 275
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
49-279 1.76e-05

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 45.95  E-value: 1.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  49 LIFAVSLLGN-VCALVLVARRRRRGATACLVLNLFCADLLFISAIPLvLAVRWTEAWLLGPVACHLL--FYVMTLSGSVT 125
Cdd:cd15187     9 LLFVFGLLGNsLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPF-QAYYLLDQWVFGNAMCKIVsgAYYIGFYSSMF 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 126 ILTLaaVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVpqrlpgADQEISICTLIWPtiPGEI 205
Cdd:cd15187    88 FITL--MSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVA------SEDGRLQCIPFYP--GQGN 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1835884573 206 SWDV----SFVTLNFLVPGLVIVISYSKILQITKASRkrltvslayseshqirvSQQDFRLFRTLFLLMVSFFIMWSP 279
Cdd:cd15187   158 SWKVftnfEVNILGLLIPFSILIFCYHNILRNLRRCH-----------------NQNKTKAIKLVFIVVIVFFLFWTP 218
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
44-323 1.89e-05

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 45.71  E-value: 1.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCALVLVA----RRRRRGATACLVLNLFCADLL-FISAIPLVLA--VRWTEAWLLGPVACHLLFY 116
Cdd:cd15130     4 TAIYLALFVVGTVGNSVTLFTLArkksLQSLQSTVRYHLGSLALSDLLiLLLAMPVELYnfIWVHHPWAFGDAGCRGYYF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 117 VMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTL 196
Cdd:cd15130    84 LRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNESDDGTHPGGLVCTP 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 197 IWPTIPGEISWDVSfVTLNFLVPGLVIVISYSKILqitkasrkrltvslayseSHQIRVSQQDFRLFRTLFLLMVSFFIM 276
Cdd:cd15130   164 IVDTATLKVVIQVN-TFMSFLFPMLVTSILNTVIA------------------NKLVQALRRGVLVLRAVVIAFVVCWLP 224
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1835884573 277 WSPIIITILLILIQNFKQDLVIWPSLFFWVV-AFTFANSALNPILYNM 323
Cdd:cd15130   225 YHVRRLMFCYISDEQWTTFLFDFYHYFYMLTnALFYVSSAINPILYNL 272
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
44-322 2.56e-05

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 45.24  E-value: 2.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCALVLV----ARRRRRGATACLVLNLFCADLL-FISAIPLVLA--VRWTEAWLLGPVACHLLFY 116
Cdd:cd15356     4 TAVYALIWALGAAGNALTIHLVlkkrSLRGLQGTVHYHLVSLALSDLLiLLISVPIELYnfVWFHYPWVFGDLVCRGYYF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 117 VMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLcVFFRVVPQRLPGADQEISICTL 196
Cdd:cd15356    84 VRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPM-AFIMGQKYELETADGEPEPSSR 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 197 IWPTIPGEISWDVsFVTLNFLVpGLVIVISYSKILQITKASRKRltvslayseshqIRVSQQDFRLFRTLFLLMVSFFIM 276
Cdd:cd15356   163 VCTVLVSRATLKV-FIQVNAFV-SFVLPLALIAFLNGVTVSHLR------------IQSLQHSVQVLRAIVIAYVICWLP 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1835884573 277 WSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTF-ANSALNPILYN 322
Cdd:cd15356   229 YHARRLMFCYVPDDAWTDSLYNFYHYFYMLTNTLFyVSSAVNPLLYN 275
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
74-321 2.58e-05

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 45.28  E-value: 2.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVH-LQRGVRGPG 151
Cdd:cd15959    35 TNVFVTSLACADLVMgLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASIETLCAIAVDRYLAITNpLRYEALVTK 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 152 RRARAVlLALIWGYSA-VAALPLCV-FFRVvpqrlpGADQEISIC--TLIWPTIPGEISWDVSFVTLNFLVPGLVIVISY 227
Cdd:cd15959   115 RRARTA-VCLVWAISAaISFLPIMNqWWRD------GADEEAQRCydNPRCCDFVTNMPYAIVSSTVSFYVPLLVMIFVY 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 228 SKI-------LQITKASRKRL---TVSLAYSESHQIR-----VSQQDFRLFRTLFLLMVSFFIMWSPiiiTILLILIQNF 292
Cdd:cd15959   188 VRVfvvatrqVRLIRKDKVRFppeESPPAESRPACGRrpsrlLAIKEHKALKTLGIIMGTFTLCWLP---FFVANIIKVF 264
                         250       260
                  ....*....|....*....|....*....
gi 1835884573 293 KQDLVIWPsLFFWVVAFTFANSALNPILY 321
Cdd:cd15959   265 CRSLVPDP-AFLFLNWLGYANSAFNPIIY 292
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
42-324 2.73e-05

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 45.11  E-value: 2.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  42 VETTVLVLIFAVSLLGN-VCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVR-WTEAWLLGPVACHLLFYVMT 119
Cdd:cd15000     1 IKSSMFLPVVLFGIFGNfVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHdFFQNYVLGSVGCKLEGFLEG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 120 LSGSVTILTLAAVSLERMVCIVHLQRGVRGpgRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQeiSICTLIWP 199
Cdd:cd15000    81 SLLLASVLALCAVSYDRLTAIVLPSEARLT--KRGAKIVIVITWIVGLLLALPLAIYRSYRERQWKNFLE--TYCAENTQ 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 200 TIPgeISWDVsFVTLNFLVPGLVIVISYSKILQITKASRKRLTVSLaysesHQIRVSQQDfRLFRTLFLLMVSFFIMWSP 279
Cdd:cd15000   157 VLP--IYWHV-IITVLVWLPLGIMLICYSAIFWKLDKYERRVLRRE-----HPSVVRYKK-KAAKTLFIVLITFVVCRIP 227
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1835884573 280 IIITILLILiQNFKQDLVI------WPSLFFWVVAFTFANSALNPILYNMT 324
Cdd:cd15000   228 FTALIFYRY-KLVPNDNTQnsvsgsFHILWFASKYLMFLNAAVNPLIYGFT 277
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
78-324 3.26e-05

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 45.20  E-value: 3.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  78 VLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGvRGPGRRARA 156
Cdd:cd15391    39 LINLAVSDLIMaLFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAIGIDRFFAVIFPLRS-RHTKSRTKC 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 157 VLlALIWGYSAvaALPLCVFFRVVPQRLPGADQEISICTLIWPtipGEISWDVSF----VTLNFLVPGLVIVISYSkILQ 232
Cdd:cd15391   118 II-ASIWAISF--SLSSVQLFAGRTQRYGQYSEGRVLCGESWP---GPDTSRSAYtvfvMLLTYIIPLLILTSTYG-YVG 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 233 ITKASRKRLTVSLAYSESHQIRVSQqdfRLFRTLFLLMVSFFIMWSPIIITILLiliQNFKQDLVIWP-----SLFFWVV 307
Cdd:cd15391   191 FRLWNRTAPGNADKGRDDMQIKSKR---KVIKMLVFVVLMFGICWLPLHLFNLV---QDFSTVFRNMPqhttrLIYGACH 264
                         250
                  ....*....|....*..
gi 1835884573 308 AFTFANSALNPILYNMT 324
Cdd:cd15391   265 WIAMSNSFVNPIIYLFM 281
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
48-321 3.32e-05

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 45.20  E-value: 3.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  48 VLIFAVSLLGN-VCALVLVARRRRRGATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVT 125
Cdd:cd15981     8 LFIFLLCMVGNgLVCFIVLKNRQMRTVTNMFILNLAVSDLLVgIFCMPTTLVDNLITGWPFDNAMCKMSGLVQGMSVSAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 126 ILTLAAVSLERMVCIVHLQRgvRGPGRRARAVLLALIWGYSAVAALPLCVFFRV--VPQRLPGADQEISI----CTLIWP 199
Cdd:cd15981    88 VFTLVAIAVERFRCIVHPFR--QKLTLRKAIVTIVIIWVLALIIMCPSAVTLTVtrEEHHFMVDDYNNSYplysCWEAWP 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 200 TIPGEISWDVSFVTLNFLVPGLVIVISYSKIlqitkaSRKRLTVSLAYSESH-----QIRVSQQDFRLFRTLFLLMVSFF 274
Cdd:cd15981   166 DTEMRKIYTTVLFSHIYLAPLTLIVIMYARI------AFKLFKSSAPIRGSQgeeeeGRRVSKRKIKVINMLIIVALFFT 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1835884573 275 IMWSPIIITILLILIQNFKQDLVIWPSLFFWVVA--FTFANSALNPILY 321
Cdd:cd15981   240 LSWLPLWTLMLLTDYGHLSEDQLNLVTVYVFPFAhwLAFFNSSVNPIIY 288
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
45-279 3.76e-05

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 44.89  E-value: 3.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLN-LFCADLLFISAIPLVLAVRW-TEAWLLGPVACHLLFYVMTLSG 122
Cdd:cd15124     5 TVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISsLALGDLLLLVTCAPVDASRYlADEWLFGRVGCKLIPFIQLTSV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 123 SVTILTLAAVSLERMVCIVHlQRGVRGPGRRARAVL-LALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTlIWPTI 201
Cdd:cd15124    85 GVSVFTLTALSADRYKAIVR-PMDIQASNALMKICLkAALIWILSMLLAIPEAVFSDLHPFYDKSTNKTFVSCA-PYPHS 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 202 PG---EISWDVSFVTLnFLVPGLVIVISYSKILQITKASRKRLTVSLAYSESHQIRVSQqdfRLFRTLFLLMVSFFIMWS 278
Cdd:cd15124   163 NElhpKIHSMASFLIF-YVIPLSIISVYYYFIAKNLIRSAYNLPVEGNVHVRRQIESRK---RLAKTVLVFVGLFAFCWL 238

                  .
gi 1835884573 279 P 279
Cdd:cd15124   239 P 239
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
41-334 3.88e-05

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 44.91  E-value: 3.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  41 AVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVL-NLFCADLLFIS-AIPLVLAVRWTEAWLLGPVACHLLFYVM 118
Cdd:cd15321     7 AAIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLvSLAAADILVATlIIPFSLANELMGYWYFRKTWCEIYLALD 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 119 TLSGSVTILTLAAVSLERMVCIVH-LQRGVRGPGRRARAVLLaLIWGYSAVAALPlCVFFRVVPQRLPGADQEISICTLI 197
Cdd:cd15321    87 VLFCTSSIVHLCAISLDRYWSVSRaIEYNSKRTPRRIKCIIL-IVWLIAAVISLP-PLIYKGKQKDEQGGLPQCKLNEEA 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 198 WPTIPGEISwdvsfvtlNFLVPGLVIVISYSKILQITKASRKRLTVSLAyseshqirvsqqdfrlfrtlfLLMVSFFIMW 277
Cdd:cd15321   165 WYILSSSIG--------SFFAPCLIMILVYLRIYLIAKNREKRFTFVLA---------------------VVIGVFVLCW 215
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1835884573 278 SPiiiTILLILIQNFKQDLVIWP----SLFFWVvafTFANSALNPILYnmTLCRNEWKKIF 334
Cdd:cd15321   216 FP---FFFSYSLGAICPELCKVPhslfQFFFWI---GYCNSSLNPVIY--TIFNQDFRRAF 268
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
77-321 4.96e-05

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 44.27  E-value: 4.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLER---MVCIVHLQRgvrgpgR 152
Cdd:cd15331    38 LILSLAVADLMVaVLVMPLSAVYEVSQHWFLGPEVCDMWISMDVLCCTASILHLVAIALDRywaVTNIDYIRR------R 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 153 RARAVLL--ALIWGYSAVAALPlcvffrvvpQRLPGADQEISICTLIwpTIPGEISWDVSFVTLN----FLVPGLVIVIS 226
Cdd:cd15331   112 TAKRILImiAVVWFVSLIISIA---------PLFGWKDEDDLDRVLK--TGVCLISQDYGYTIFStvgaFYVPLLLMIII 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 227 YSKILQITKASRKRLtvslayseshqirvsqqdfrlfRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWV 306
Cdd:cd15331   181 YWKIYQAAKRERKAA----------------------RTLAIITGAFVVCWLPFFLVALVMPFCGAWQISRFLESFFLWL 238
                         250
                  ....*....|....*
gi 1835884573 307 vafTFANSALNPILY 321
Cdd:cd15331   239 ---GYFNSLLNPIIY 250
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
78-245 5.31e-05

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 44.40  E-value: 5.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  78 VLNLFCADLLFISAIPLvlavrWT------EAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPG 151
Cdd:cd15366    39 LLNLSVSDLLYIATLPL-----WIdyflhrDNWIHGPESCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFAKVRR 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 152 RRARAVLLALIWGYSAVAALPLCVFFRVVPQRLpgadqEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKIL 231
Cdd:cd15366   114 VKTAVAVSAVVWAIEIGANSAPLFHDELFRDRY-----NHTFCFEKYPMEDWVAWMNLYRVFVGFLFPWVLMLFSYRGIL 188
                         170       180
                  ....*....|....*....|....
gi 1835884573 232 ----------QITKASRKRLTVSL 245
Cdd:cd15366   189 ravrgnvsteQQEKAKIKRLALSL 212
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
86-318 6.38e-05

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 44.14  E-value: 6.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  86 LLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGY 165
Cdd:cd15123    48 LLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQLTSVGVSVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIV 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 166 SAVAALPLCVFFRVVPQRLPGADQEISICTL--IWPTIPGEISWDVSFVTLnFLVPGLVIVISYSKILQITKASRKRLTv 243
Cdd:cd15123   128 SMLFAIPEAVFSDLYSFRDPEKNTTFEACAPypVSEKILQEIHSLLCFLVF-YIIPLSIISVYYFLIARTLYKSTFNMP- 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 244 slAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPiiiTILLILIQNFKQDLVIWPSLFFWVV-----AFTFANSALNP 318
Cdd:cd15123   206 --AEEHSHARKQIESRKRVAKTVLVLVALFAFCWLP---NHILYLYRSFTYHTSVDSSAFHLIAtifsrVLAFSNSCVNP 280
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
41-279 6.68e-05

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 44.06  E-value: 6.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  41 AVETTVLVLIFAVSLLGNVCAL-VLVARRRRRGATACLVLNLFCADLL---FISAIPLVLAVRwtEAWLLGPVACHLLFY 116
Cdd:cd16004     1 ALWAIAYSLIVLVAVTGNATVIwIILAHRRMRTVTNYFIVNLALADLSmaaFNTAFNFVYASH--NDWYFGLEFCRFQNF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 117 VMTLSGSVTILTLAAVSLERMVCIVH-LQRGVRGPGRRaraVLLALIWGYSAVAALPLCVFFRVVpqrlpgADQEISICT 195
Cdd:cd16004    79 FPITAMFVSIYSMTAIAADRYMAIIHpFKPRLSAGSTK---VVIAGIWLVALALAFPQCFYSTVT------MDQGRTKCI 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 196 LIWPTIPG---EISWDVSFVTLNFLVPGLVIVISYSKIlQITKASRKRLTVSLAYSESHQIRVSQqdfRLFRTLFLLMVS 272
Cdd:cd16004   150 VAWPGDSGgkhQLTYHLAVIVLIYLLPLAVMFVTYSII-GITLWRSAVPGHQAHGAYHRQLQAKK---KFVKTMVVVVVT 225

                  ....*..
gi 1835884573 273 FFIMWSP 279
Cdd:cd16004   226 FAICWLP 232
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
44-323 8.55e-05

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 43.72  E-value: 8.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVL-NLFCADLLFISAIPLVLAVRWT-EAWLLGPVACHLLFYVMTLS 121
Cdd:cd15131     4 TVTCVLLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLsSMAFSDLLIFLCMPLDLYRLWQyRPWNFGDLLCKLFQFVSESC 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 122 GSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTI 201
Cdd:cd15131    84 TYSTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIFVLVGVEHENGTNPIDTNECKATEYAVR 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 202 PGEISWDVSFVTLNFLVPGLVIVISYSKILQitKASRKRLTVSLAySESHQIRVSQQDFRLfrtLFLLMVSFFIMWSPiI 281
Cdd:cd15131   164 SGLLTIMVWVSSVFFFLPVFCLTVLYSLIGR--KLWRRRRENIGP-NASHRDKNNRQTVKM---LAVVVFAFVLCWLP-F 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1835884573 282 ITILLILIQNFKQDLVIWP--SLFFWVVAFT--FANSALNPILYNM 323
Cdd:cd15131   237 HVGRYLFSKSFEAGSLEIAliSQYCNLVSFVlfYLSAAINPILYNI 282
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
79-321 9.26e-05

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 43.60  E-value: 9.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  79 LNLFCADLLFISAIPLVLAVRWTEA-WLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHlqrgvrgP--GRRAR 155
Cdd:cd15115    39 LNLAVADLLCCLSLPFSIAHLLLNGhWPYGRFLCKLLPSIIVLNMFASVFTLTAISLDRFLLVIK-------PvwAQNHR 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 156 AVLLA-----LIWGYSAVAALPLCVFFRVVpqrlpgADQEISICTLIWptipgEISWDVSFVTLNFLVPGLVIVISYSKI 230
Cdd:cd15115   112 SVLLAcllcgCIWILALLLCLPVFIYRTTV------TDGNHTRCGYDF-----LVAITITRAVFGFLLPLLIIAACYSFI 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 231 LQITKASRKRLTVSlayseshqirvsqqdfRLFRTLFLLMVSFFIMWSP--IIITILLILIQNFKQDLVIWPSLffwVVA 308
Cdd:cd15115   181 AFRMQRGRFAKSQS----------------KTFRVIIAVVVAFFVCWAPyhIIGILSLYGDPPLSKVLMSWDHL---SIA 241
                         250
                  ....*....|...
gi 1835884573 309 FTFANSALNPILY 321
Cdd:cd15115   242 LAYANSCLNPVLY 254
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
77-334 1.93e-04

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 42.69  E-value: 1.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVH--LQRGVRGPGRR 153
Cdd:cd15049    38 FLLSLACADLIIgLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYVASNASVMNLLLISFDRYFSVTRplTYRAKRTPKRA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 154 ARAVLLAliWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIpgeiswdvSFVT--LNFLVPGLVIVISYSKIL 231
Cdd:cd15049   118 ILMIALA--WVISFVLWAPAILGWQYFVGERTVPDGQCYIQFLDDPAI--------TFGTaiAAFYLPVLVMTILYWRIY 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 232 QITKASRKrltvslayseshqirvsqqdfrLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWpSLFFWVvafTF 311
Cdd:cd15049   188 RETARERK----------------------AARTLSAILLAFIITWTPYNILVLVSTFCAKCIPDTLW-SFGYWL---CY 241
                         250       260
                  ....*....|....*....|...
gi 1835884573 312 ANSALNPILYnmTLCRNEWKKIF 334
Cdd:cd15049   242 INSTINPFCY--ALCNKTFRKTF 262
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
77-173 1.94e-04

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 42.62  E-value: 1.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLFISAI-PLVLAV----RWteaWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVH-LQRGVRGP 150
Cdd:cd14981    40 LVAGLAITDLLGILLTsPVVLAVyasnFE---WDGGQPLCDYFGFMMSFFGLSSLLIVCAMAVERFLAITHpFFYNSHVK 116
                          90       100
                  ....*....|....*....|....
gi 1835884573 151 GRRARAVlLALIWGYSAV-AALPL 173
Cdd:cd14981   117 KRRARLM-LGAVWAFALLiASLPL 139
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
49-279 2.16e-04

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 42.46  E-value: 2.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  49 LIFAVSLLGNVCALVLVARRRRRG--ATACLVLNLFCADLLFISAIPLvLAVRWTEAWLLGPVACHLLFYVMTLSGSVTI 126
Cdd:cd15188     9 LVFLLGLAGNLLLFVVLLLYVPKKkkMTEVYLLNLAVSDLLFLVTLPF-WAMYVAWHWVFGSFLCKFVSTLYTINFYSGI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 127 LTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRV--VPQRLPGADQEISICTLIWptipgE 204
Cdd:cd15188    88 FFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQThhTNNGVWVCHADYGGHHTIW-----K 162
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1835884573 205 ISWDVSFVTLNFLVPGLVIVISYSKILQITKASRkrltvslayseshqirvSQQDFRLFRTLFLLMVSFFIMWSP 279
Cdd:cd15188   163 LVFQFQQNLLGFLFPLLAMVFFYSRIACVLTRLR-----------------PPGQGRALRFVAALVVVFFVLWFP 220
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
77-321 2.21e-04

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 42.26  E-value: 2.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLL--FYVMTLSGSvtILTLAAVSLERMVCIVH-LQRGVRGPGR 152
Cdd:cd15329    38 LIVSLAVSDLLVaLLVMPLAIIYELSGYWPFGEILCDVWisFDVLLCTAS--ILNLCAISVDRYLVITRpLTYAVKRTPK 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 153 RArAVLLALIWGYSAVAALPlCVFFRVVPQRLPGADQeisICTLIWPTIpgeiswdvsFVTL-NFLVPGLVIVISYSKIL 231
Cdd:cd15329   116 RM-ALMIAIVWLLSALISIP-PLFGWKNKVNDPGVCQ---VSQDFGYQI---------YATFgAFYIPLIVMLVLYYKIY 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 232 QITKASRKRLTvslayseshqirvsqqdfrlfrTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTF 311
Cdd:cd15329   182 RAAKSERKAIK----------------------TLGIIMGAFTLCWLPFFILALLRPFLKPIKCSCIPLWLSRLFLWLGY 239
                         250
                  ....*....|
gi 1835884573 312 ANSALNPILY 321
Cdd:cd15329   240 ANSFLNPIIY 249
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
74-233 2.21e-04

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 42.42  E-value: 2.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLFISAIPLvLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRgvRGPGRR 153
Cdd:cd15176    35 TDVYILNLAVADLLLLFTLPF-WAADAVNGWVLGTAMCKITSALYTMNFSCGMQFLACISVDRYVAITKATS--RQFTGK 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 154 ARAVLLALIWGYSAVAALPLCVFFRVvpqrlpGADQEISICTLIWPT---IPGEISWDVSFVTLNFLVPGLVIVISYSKI 230
Cdd:cd15176   112 HCWIVCLCVWLLAILLSIPDLVFSTV------RENSDRYRCLPVFPPslvTSAKATIQILEVLLGFVLPFLVMVFCYSRV 185

                  ...
gi 1835884573 231 LQI 233
Cdd:cd15176   186 ARA 188
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
48-279 2.61e-04

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 42.13  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  48 VLIFAVSLLGNVCALVLVARRRRRGA-TACLVLNLFCADLLFISAIPLvlavrWTE----AWLLGPVACHLL--FYVMTL 120
Cdd:cd15186     8 SLVFAFGLVGNLLVVLALTNSGKSKSiTDIYLLNLALSDLLFVATLPF-----WTHylinEWGLHNAMCKLTtaFFFIGF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 121 SGSVTILTLaaVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEisICTLIWPT 200
Cdd:cd15186    83 FGGIFFITV--ISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMFTKMKENECLGDYPE--VLQEIWPV 158
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1835884573 201 IpgeisWDVSFVTLNFLVPGLVIVISYSKILQitkasrkrltvSLAYSESHqirvsqQDFRLFRTLFLLMVSFFIMWSP 279
Cdd:cd15186   159 L-----RNVELNFLGFLLPLLIMSYCYFRIIQ-----------TLFSCKNH------KKARAIKLILLVVIVFFLFWTP 215
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
76-246 2.63e-04

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 42.05  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  76 CLVlNLFCADLLF----ISAIPLVLAVRwteawlLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPG 151
Cdd:cd15220    40 CVV-DLLAALLLMplgiLSSSPFFLGVV------FGEAECRVYIFLSVCLVSASILTISAISVERYYYIVHPMRYEVKMT 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 152 RRARAVLLALIWGYS-AVAALPLCVFfrvvPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKI 230
Cdd:cd15220   113 IGLVAAVLVGVWVKAlLLGLLPVLGW----PSYGGPAPIAARHCSLHWSHSGHRGVFVVLFALVCFLLPLLLILVVYCGV 188
                         170
                  ....*....|....*.
gi 1835884573 231 LQITKASRKRLTVSLA 246
Cdd:cd15220   189 FKVFGGGKAALTLAAI 204
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
73-321 2.91e-04

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 41.96  E-value: 2.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  73 ATACLVLNLFCADLLFISAI-PLVLAVRWTEA-WLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIvhlQRGVRGP 150
Cdd:cd15067    33 VTNYFIVSLAVADLLVGSIVmPFSILHEMTGGyWLFGRDWCDVWHSFDVLASTASILNLCVISLDRYWAI---TDPISYP 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 151 GRRAR---AVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQeisiCTLIWPTIPGEISWDVSFvtlnfLVPGLVIVISY 227
Cdd:cd15067   110 SRMTKrraLIMIALVWICSALISFPAIAWWRAVDPGPSPPNQ----CLFTDDSGYLIFSSCVSF-----YIPLVVMLFTY 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 228 SKILQItkASRKRltvslayseshqirvsqqdfRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQdlVIWPSLFFWVV 307
Cdd:cd15067   181 YRIYRA--AAKEQ--------------------KAAKTLGIVMGVFILCWLPFFVTNILIGFCPSNC--VSNPDILFPLV 236
                         250
                  ....*....|....*
gi 1835884573 308 AFT-FANSALNPILY 321
Cdd:cd15067   237 TWLgYINSGMNPIIY 251
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
78-292 2.95e-04

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 42.05  E-value: 2.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  78 VLNLFCADLLFISAIPLvLAVRWTEAWLLGPVACHL---LFYVMTLSGSVTILTLaavSLERMVCIVHLQRGVRGPGRRA 154
Cdd:cd15184    39 LLNLAISDLLFLLTLPF-WAHYAANEWVFGNAMCKLltgLYHIGFFSGIFFIILL---TIDRYLAIVHAVFALKARTVTF 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 155 RAVLLALIWGYSAVAALPLCVFFRvvpqrlpgADQEISICTLIwPTIPGE--ISWD----VSFVTLNFLVPGLVIVISYS 228
Cdd:cd15184   115 GVVTSVVTWVVAVFASLPGIIFTK--------SQKEGSHYTCS-PHFPPSqyQFWKnfqtLKMNILGLVLPLLVMIICYS 185
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1835884573 229 KILQITKasrkrltvslayseshQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNF 292
Cdd:cd15184   186 GILKTLL----------------RCRNEKKRHKAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEF 233
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
44-321 3.01e-04

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 42.14  E-value: 3.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGN--VCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHL---LFYVM 118
Cdd:cd15403     4 AIVMILMIAIGFLGNaiVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRIsamLYWFF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 119 TLSGsVTILTLaaVSLERMVCIVhlQRGVRGPGRRARaVLLALIWGYSAVAALPLCVFFRV--VPQRLPGadqeisiCTL 196
Cdd:cd15403    84 VLEG-VAILLI--ISVDRFLIIV--QRQDKLNPHRAK-VMIAISWVLSFCISFPSVVGWTLveVPARAPQ-------CVL 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 197 IWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRL---TVSLAYSE-----------SHQIRVSQQ-DFR 261
Cdd:cd15403   151 GYTESPADRVYAVLLVVAVFFVPFSIMLYSYLCILNTVRRNAVRIhnhADSLCLSQvsklglmglqrPHQMNVDMSfKTR 230
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1835884573 262 LFRTLFLLMVSFFIMWSPIIITILLILiqnFKQDLVIWPSLFF---WVVAFTFANSALNPILY 321
Cdd:cd15403   231 AFTTILILFVGFSLCWLPHTVFSLLSV---FSRRFYYSSSFYPistCVLWLSYLKSVFNPVIY 290
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
78-334 3.13e-04

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 41.94  E-value: 3.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  78 VLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVH--LQRGVRGPGRRA 154
Cdd:cd15300    39 LLSLACADLIIgIFSMNLYTSYILMGYWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRplTYRAKRTPKRAG 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 155 RAVLLALIWGYSAVAALPLCVFFRVVPQRLPgaDQEISICTLIWPTIpgeiswDVSFVTLNFLVPGLVIVISYSKILQIT 234
Cdd:cd15300   119 IMIGLAWLISFILWAPPILCWQYFVGKRTVP--ERECQIQFLSEPTI------TFGTAIAAFYIPVSVMTILYCRIYKET 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 235 KASRKRLtvslayseshqirvsqqdfrlfRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWpSLFFWVVaftFANS 314
Cdd:cd15300   191 IKERKAA----------------------QTLSAILLAFIITWTPYNIMVLVSTFCSDCIPLTLW-HLGYWLC---YVNS 244
                         250       260
                  ....*....|....*....|
gi 1835884573 315 ALNPILYnmTLCRNEWKKIF 334
Cdd:cd15300   245 TVNPMCY--ALCNKTFRKTF 262
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
73-334 3.85e-04

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 41.71  E-value: 3.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  73 ATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVhlqRGVRGPG 151
Cdd:cd15063    34 VTNLFIVSLACADLLVgTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMCTASILNLCAISLDRYLAIT---RPIRYPS 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 152 ----RRARAvLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTipGEISWDVSFVTLNFLVPGLVIVISY 227
Cdd:cd15063   111 lmstKRAKC-LIAGVWVLSFVICFPPLVGWNDGKDGIMDYSGSSSLPCTCELT--NGRGYVIYSALGSFYIPMLVMLFFY 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 228 SKILqitkasrkrltvslayseshqiRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWpSLFFWVv 307
Cdd:cd15063   188 FRIY----------------------RAARMETKAAKTVAIIVGCFIFCWLPFFTVYLVRAFCEDCIPPLLF-SVFFWL- 243
                         250       260
                  ....*....|....*....|....*..
gi 1835884573 308 afTFANSALNPILYnmTLCRNEWKKIF 334
Cdd:cd15063   244 --GYCNSALNPCIY--ALFSRDFRFAF 266
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
74-321 4.16e-04

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 41.46  E-value: 4.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVAC--HLLFYVMtLSgSVTILTLAAVSLERMVCIVHLQRGVRGP 150
Cdd:cd15314    35 TNYLILSLAVADLLVgGLVMPPSMVRSVETCWYFGDLFCkiHSSFDIT-LC-TASILNLCFISIDRYYAVCQPLLYRSKI 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 151 GRRARAVLLALIWGYSAVAAlpLCVFFrvVPQRLPGADQEISICTLIWPTIPGEISWDVSFVtLNFLVPGLVIVISYSKI 230
Cdd:cd15314   113 TVRVVLVMILISWSVSALVG--FGIIF--LELNIKGIYYNHVACEGGCLVFFSKVSSVVGSV-FSFYIPAVIMLCIYLKI 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 231 LQItkASRKRLTVSLAYSESHQIrVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKqdlvIWPSLFFWVVAFT 310
Cdd:cd15314   188 FLV--AQRQARSIQSARTKSGAS-SSKMERKATKTLAIVMGVFLLCWTPFFLCNIIDPFINYS----IPPVLIEVLNWLG 260
                         250
                  ....*....|.
gi 1835884573 311 FANSALNPILY 321
Cdd:cd15314   261 YSNSTLNPFIY 271
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
77-334 4.89e-04

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 41.16  E-value: 4.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVhlqRGVRGPGRRAR 155
Cdd:cd15298    38 FLFSLACADLIIgAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVT---KPLTYPARRTT 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 156 ---AVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTipgeiswdVSFVT--LNFLVPGLVIVISYski 230
Cdd:cd15298   115 kmaGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPA--------VTFGTaiAAFYLPVVIMTVLY--- 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 231 lqitkasrkrLTVSLAyseshqirvSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWpSLFFWVVaft 310
Cdd:cd15298   184 ----------IHISLA---------SARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVW-SIGYWLC--- 240
                         250       260
                  ....*....|....*....|....
gi 1835884573 311 FANSALNPILYnmTLCRNEWKKIF 334
Cdd:cd15298   241 YVNSTINPACY--ALCNATFKKTF 262
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
104-234 5.73e-04

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 41.07  E-value: 5.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 104 WLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRgvrgPGRRARA--VLLALIWGYSAVAALPLCVF--FRV 179
Cdd:cd16003    66 WYFGEAYCRFHNFFPITSVFASIYSMTAIAVDRYMAIIDPLK----PRLSATAtkVVIGSIWILAFLLAFPQCLYskTKV 141
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1835884573 180 VPQRlpgadqeiSICTLIWPTIPGE-ISWDVSFVTLNFLVPGLVIVISYSkILQIT 234
Cdd:cd16003   142 MPGR--------TLCFVAWPGGPDQhFTYHIIVIVLVYCLPLLVMGITYT-IVGIT 188
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
86-323 5.79e-04

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 41.08  E-value: 5.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  86 LLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVH-LQRGVRGPGRRArAVLLALIWG 164
Cdd:cd15214    47 LLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGAIAIDRYYAVLYpMVYPMKITGNRA-VLALVYIWL 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 165 YSAVAALPLCVFFRVVPqrlpgADQEISICTLIWPTipgEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRkrltvs 244
Cdd:cd15214   126 HSLIGCLPPLFGWSSLE-----FDRFKWMCVAAWHK---EAGYTAFWQVWCALLPFVVMLVCYGFIFRVARANQ------ 191
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1835884573 245 layseshqirvsqqdFRLFRTLFLLMVSFFIMWSPiiiTILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNM 323
Cdd:cd15214   192 ---------------CKAFITILVVLGAFVTTWGP---YMVVISTEALWGKNSVSPQLETLATWLSFTSAVCHPLIYGL 252
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
42-196 7.63e-04

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 40.99  E-value: 7.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  42 VETTVLVLIFAVSLLGNVCALVLVAR-RRRRGATACLVLNLFCADLLFISA-IPLVLAVRWTEAWLLGPVACHLLFYVMT 119
Cdd:cd15976     2 INTVVSCLVFVLGIIGNSTLLRIIYKnKCMRNGPNILIASLALGDLLHIIIdIPINVYKLLAEDWPFGVEMCKLVPFIQK 81
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1835884573 120 LSGSVTILTLAAVSLERMVCIVHLQRgVRGPG-RRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADqeISICTL 196
Cdd:cd15976    82 ASVGITVLSLCALSIDRYRAVASWSR-IKGIGvPKWTAVEIVLIWVVSIILAVPEAIGFDMITMDYKGEL--LRICLL 156
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
211-334 7.72e-04

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 40.63  E-value: 7.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 211 FVTLNFLVPGLVIVISYSKILQITKASRKRLTVSLAYSESHqiRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQ 290
Cdd:cd15346   160 FCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNIRKAS--RSSEKSMALLKTVIIVLSVFIACWAPLFILLLLDVGC 237
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1835884573 291 NFKQDLVIWPSLFFWVVAFTfaNSALNPILYnmTLCRNEWKKIF 334
Cdd:cd15346   238 KVKTCSILFKAEYFLVLAVL--NSATNPIIY--TLTNKEMRRAF 277
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
79-321 9.27e-04

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 40.52  E-value: 9.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  79 LNLFCADLLFISAIPLVLAVRWTEA-WLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAV 157
Cdd:cd15116    39 LNLAVADFLFTFFLPFSIAYTAMDFhWPFGRFMCKLNSFLLFLNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASL 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 158 LLALIWgysaVAALPLCVFFRVVPQRLPGADQEISIC----TLIWPTIPGEISW---------DVSFVTLNFLVPGLVIV 224
Cdd:cd15116   119 VSLAVW----VVAFFLSSPSFIFRDTAPSQNNNKIICfnnfSLSGDNSSPEVNQlrnmrhqvmTITRFLLGFLIPFTIII 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 225 ISYSKIlqITKASRKRLTVSLayseshqirvsqqdfRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFF 304
Cdd:cd15116   195 CCYAAI--VLKLKRNRLAKSS---------------KPFKIIAAVIVTFFLCWAPYHILNLLEMEATRSPASVFKIGLPI 257
                         250
                  ....*....|....*..
gi 1835884573 305 wVVAFTFANSALNPILY 321
Cdd:cd15116   258 -TSSLAFINSCLNPILY 273
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
77-240 9.35e-04

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 40.49  E-value: 9.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMvCIVHLQRGVRGPGRRAR 155
Cdd:cd15086    38 LLLNISLSDLLVcVLGTPFSFAASTQGRWLIGEHGCRWYGFANSLFGIVSLISLAVLSYERY-CTLLRPTEADVSDYRKA 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 156 AVLLALIWGYSAVAALPLCVFFRVVPQRLPGadqeiSICTLIWPT-IPGEISWDVSFVTLNFLVPGLVIVISYSKIL--- 231
Cdd:cd15086   117 WLGVGGSWLYSLLWTLPPLLGWSSYGPEGPG-----TTCSVQWTSrSANSISYIICLFIFCLLLPFLVMVYCYGRLLyai 191
                         170
                  ....*....|....
gi 1835884573 232 -QITK----ASRKR 240
Cdd:cd15086   192 kQVGKinksTARKR 205
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
77-279 1.01e-03

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 40.55  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRAr 155
Cdd:cd15082    51 IIVNLSVADFLVsLTGGTISFLTNARGYFFLGVWACVLEGFAVTFFGIVALWSLAVLAFERFFVICRPLGNIRLQGKHA- 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 156 AVLLALIWGYSAVAALPLCVFFRVVPQRLPGadqeiSICTLIWPTipGEI---SWDVSFVTLNFLVPGLVIVISYSKILQ 232
Cdd:cd15082   130 ALGLLFVWTFSFIWTIPPVLGWSSYTVSKIG-----TTCEPNWYS--GNMhdhTYIITFFTTCFILPLGVIFVSYGKLLQ 202
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1835884573 233 -ITKASRKRLTVSLAYSESHQIRvsqqdfrlfRTLFLLMVSFFIMWSP 279
Cdd:cd15082   203 kLRKVSNTQGRLGNARKPERQVT---------RMVVVMIVAFMVCWTP 241
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
74-334 1.10e-03

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 40.27  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADL---LFISAIPLVLAVRWTeaWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRgVRGP 150
Cdd:cd15958    35 TNLFITSLACADLvmgLLVVPFGATLVVRGR--WLYGSFFCELWTSVDVLCVTASIETLCVIAIDRYLAITSPFR-YQSL 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 151 GRRARA-VLLALIWGYSA-VAALPLCV-FFRVVPQRLPGADQEISICTLIwptipGEISWDVSFVTLNFLVPGLVIVISY 227
Cdd:cd15958   112 LTRARAkGIVCTVWAISAlVSFLPIMMhWWRDEDDQALKCYEDPGCCDFV-----TNRAYAIASSIISFYIPLLIMIFVY 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 228 SKIL--------QITKASRKRLTVSLAYSESHQIRVSQ----QDFRLFRTLFLLMVSFFIMWSPIIITILLILiqnFKQD 295
Cdd:cd15958   187 LRVYreakkqikKIDKCEGRFHNTLTGLGRKCKRRPSRilalREQKALKTLGIIMGVFTLCWLPFFLVNVVNV---FNRE 263
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1835884573 296 LVIwPSLFFWVVAFTFANSALNPILYnmtlCRN-EWKKIF 334
Cdd:cd15958   264 LVP-DWLFVFFNWLGYANSAFNPIIY----CRSpDFRKAF 298
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
78-321 1.26e-03

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 40.15  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  78 VLNLFCADLLFISAIPLVLAVRWT-EAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARA 156
Cdd:cd15365    39 LFNLSLSDLLYIVILPLWIDYLWNgDNWTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTAL 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 157 VLLALIWgysavaALPLCVFFRVVPQR-LPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITK 235
Cdd:cd15365   119 SVSVAIW------LLEICFNAVILTWEdSFHESSSHTLCYDKFPLEDWQARLNLFRICLGYLLPLLIILFCYWKIYQAVR 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 236 asrkrltvslayseSHQIRVSQQDFRLFRTLFLLMVSFFIMWSPI-IITILLILIQNFKQDLVIWP-SLFFWVVAFTFAN 313
Cdd:cd15365   193 --------------SNQATEDQEKKKIFKLLLLITVTFVICFTPYhVVLLIRSIVEPCDCRNAKWLyTLYKITVALTSLN 258

                  ....*...
gi 1835884573 314 SALNPILY 321
Cdd:cd15365   259 CIADPFLY 266
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
44-144 1.28e-03

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 40.22  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCALVLVA-RRRRRGATACLVLNLFCADLLFIS-AIPLVLAVRWTEAWLLGPVACHLLFYVMTLS 121
Cdd:cd15127     4 MCLSVVIFGIGIMGNVAVMCIVChNYYMRSISNSLLANLAFWDFLIIFfCLPLVIFHELTKKWLLGDFSCKIVPYIEVAS 83
                          90       100
                  ....*....|....*....|...
gi 1835884573 122 GSVTILTLAAVSLERMVCIVHLQ 144
Cdd:cd15127    84 LGVTTFTLCALCIDRFRAATNVQ 106
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
77-334 1.30e-03

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 39.93  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRAR 155
Cdd:cd15334    38 LICSLAVTDFLVaVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 156 AVLLALIWGYSAVAALPlCVFFRvvPQRLPGADQEISICTLIWPTIPGEISwdvsfvtlNFLVPGLVIVISYSKILQITK 235
Cdd:cd15334   118 GIMIAVVWIISIFISMP-PLFWR--HQTTSREDECIIKHDHIVFTIYSTFG--------AFYIPLALILILYYKIYRAAT 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 236 ASRKRLTvslayseshqirvsqqdfrlfrTLFLLMVSFFIMWSPIIITILLIliqNFKQDLVIWPSLFFWVVAFTFANSA 315
Cdd:cd15334   187 RERKAAT----------------------TLGLILGAFVICWLPFFVKEVIV---NTCDSCYISEEMSNFLTWLGYINSL 241
                         250
                  ....*....|....*....
gi 1835884573 316 LNPILYnmTLCRNEWKKIF 334
Cdd:cd15334   242 INPLIY--TIFNEDFKKAF 258
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
42-230 1.33e-03

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 39.83  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  42 VETTVLVLIFAVSLLGN-VCALVLVARRRRRGATACLVLNLFCADLLFISAI-PLVLAVRWTEAWLLGPVACHLLFYVMT 119
Cdd:cd15215     1 IRSVLIVIFLCASLFGNiVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVmPWVIATSVPLFWPLDSHLCTALVVLMH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 120 LSGSVTILTLAAVSLERMVCIVH-LQRGVRGPGRRArAVLLALIWGYSAVAALPLCVFFRVVpqrlpGADQEISICTLIW 198
Cdd:cd15215    81 LFAFAGVNTIVVVSVDRYLAIIHpLSYPTKMTPRRG-YLLIYGTWIVSVLQSTPPLYGWGQA-----AFDERNALCSVIW 154
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1835884573 199 PTIPgeiSWDVSFVTLNFLVPGLVIVISYSKI 230
Cdd:cd15215   155 GSSY---SYTILSVVSSFVLPVIIMLACYSMV 183
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
78-328 1.36e-03

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 40.10  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  78 VLNLFCADLL--FISAIPlVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGpGRRAR 155
Cdd:cd15197    39 ITQLAIADLCvgLINVLT-DIIWRITVEWRAGDFACKVIRYLQVVVTYASTYVLVALSIDRYDAICHPMNFSQS-GRQAR 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 156 aVLLALIWGYSAVAALPLCVFFRvvpQRLPGADQEisICTLIWPTipgEISWDVSFVTLNFLV---PGLVIVISYSKILQ 232
Cdd:cd15197   117 -VLICVAWILSALFSIPMLIIFE---KTGLSNGEV--QCWILWPE---PWYWKVYMTIVAFLVffiPATIISICYIIIVR 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 233 -ITKASRKRLTVSLAYSESHQIR-------VSQQDFRLFRTLFLLMVSFFIMWSPiiiTILLILIQNF-----KQDLVIW 299
Cdd:cd15197   188 tIWKKSKIQVTINKAGLHDGSSRrsssrgiIPRAKIKTIKMTFVIVTVFIICWSP---YFVFDLLDVFgllprSKTKIAA 264
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1835884573 300 PSLFFWVVAFtfaNSALNPILY---NMTLCRN 328
Cdd:cd15197   265 ATFIQSLAPL---NSAINPLIYclfSTHLCRP 293
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
74-321 1.54e-03

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 39.88  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLFISAI-PLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHlqrGVRGPG- 151
Cdd:cd15326    35 TNYFIVNLAIADLLLSFTVlPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRH---SLQYPTi 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 152 -RRARAVLLAL-IWGYSAVAAL-PLCVFfrvvPQRLPGADQEISICTLIWPTIpgeiswdvsFVTL-NFLVPGLVIVISY 227
Cdd:cd15326   112 vTRKRAILALLgVWVLSTVISIgPLLGW----KEPAPPDDKVCEITEEPFYAL---------FSSLgSFYIPLIVILVMY 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 228 SKILQIT-KASRKRltvslayseshqirvsqqdfRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWV 306
Cdd:cd15326   179 CRVYIVAlKFSREK--------------------KAAKTLGIVVGMFILCWLPFFIALPLGSLFSHLKPPETLFKIIFWL 238
                         250
                  ....*....|....*
gi 1835884573 307 VAFtfaNSALNPILY 321
Cdd:cd15326   239 GYF---NSCLNPIIY 250
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
47-321 1.66e-03

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 39.79  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  47 LVLIFAVSLLGNVCALVLVARRRRRGATA-CLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSV 124
Cdd:cd15054     7 LCLIILLTVAGNSLLILLIFTQRSLRNTSnYFLVSLFMSDLMVgLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 125 TILTLAAVSLERMVCIVH-LQRGVRGPGRRArAVLLALIWGYSAVAAlplcvfFRVVPQRLPGADQEISICTLIWPTIPG 203
Cdd:cd15054    87 SILNLCVISLDRYLLIISpLRYKLRMTPPRA-LALILAAWTLAALAS------FLPIELGWHELGHERTLPNLTSGTVEG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 204 EISWDVSFV------TLNFLVPGLVIVISYSKILqitKASRKRLTVSLayseshqirvsqqdfrlfrTLFLLMVSFFIMW 277
Cdd:cd15054   160 QCRLLVSLPyalvasCLTFFLPSGAICFTYCRIL---LAARKALKASL-------------------TLGILLGMFFVTW 217
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1835884573 278 SPIIITILLILIQNfkqdlVIWPSLFFWVVAFTFANSALNPILY 321
Cdd:cd15054   218 LPFFVANVVQAVCD-----CVSPGLFDVLTWLGYCNSTMNPIIY 256
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
74-321 1.68e-03

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 39.73  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLFISAIPLVlAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRgpGRR 153
Cdd:cd15181    35 TENYLLHLALADLLLLLTFPFS-VVESIAGWVFGTFLCKLVGAIHKLNFYCSSLLLACISVDRYLAIVHAIHSYR--HRR 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 154 ARAVLLA--LIWGYSAVAALPLCVFFRVVpqrlPGADQEISICTLIWPTIPGEISWDVS-FVT--LNFLVPGLVIVISYS 228
Cdd:cd15181   112 LRSVHLTcgSIWLVCFLLSLPNLVFLEVE----TSTNANRTSCSFHQYGIHESNWWLTSrFLYhvVGFFLPLLIMGYCYA 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 229 KILQITKASRKRLTVSLAyseshqIRVSqqdfrlfrtlFLLMVSFFIMWSP---IIITILLILIQNFKQDLVIWPSLFFW 305
Cdd:cd15181   188 TIVVTLCQSSRRLQKQKA------IRVA----------ILVTLVFCLCWLPyniVIFLDTLDDLKAVVKNCKLNDLLDAA 251
                         250
                  ....*....|....*....
gi 1835884573 306 VV---AFTFANSALNPILY 321
Cdd:cd15181   252 ITvteSLGFSHCCLNPILY 270
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
42-279 1.83e-03

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 39.81  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  42 VETTVLVLIFAVSLLGNVCALVLVAR-RRRRGATACLVLNLFCADLLFIS-AIPL----VLAVRWT-EAWLLGPVACHLL 114
Cdd:cd15128     2 INTVVSCLIFIVGIIGNSTLLRIIYQnKCMRNGPNALIASLALGDLLYIViDLPInvykLLAMDWPfGDQPFGQFLCKLV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 115 FYVMTLSGSVTILTLAAVSLERMVCIVHLQRgVRGPG-RRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGadQEISI 193
Cdd:cd15128    82 PFIQKASVGITVLNLCALSVDRYRAVASWSR-IQGIGiPMWTAVEIVMIWMLSAVLAVPEAIGFDMVRFNYKG--VTLRT 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 194 CTLIWPTIPGEISWDVS---FVTLNFLVPgLVIVISYSKILQITKASRKRLTVSLAYSEShqirvSQQDFRLFRTLFLLM 270
Cdd:cd15128   159 CLLRPETSFMKFYIDVKdwwLFGFYFCLP-LVCTAIFYTLMTCEMLRKRNGMLRIALNEH-----LKQRREVAKTVFCLV 232

                  ....*....
gi 1835884573 271 VSFFIMWSP 279
Cdd:cd15128   233 VIFALCWLP 241
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
77-323 1.88e-03

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 39.39  E-value: 1.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVH-LQRGVRGPGRRA 154
Cdd:cd15333    42 LIASLAVTDLLVsILVMPISIVYTVTGTWTLGQVVCDIWLSSDITCCTASILHLCVIALDRYWAITDaVEYSKKRTPKRA 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 155 rAVLLALIWGYSAVAALPlCVFFRVVPqrlpgADQEISICTLIwptiPGEISWDVSFVTLNFLVPGLVIVISYSKILQIT 234
Cdd:cd15333   122 -AVMIALVWVISISISLP-PFFWRQAK-----AEEEVSECVVN----TDHILYTVYSTVGAFYIPTLLLIALYGRIYVEA 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 235 KASRKRLTvslayseshqirvsqqdfrlfRTLFLLMVSFFIMWSPIIITILLILIqnFKQDLVIWPSLFFWVVAFTFANS 314
Cdd:cd15333   191 RARERKAT---------------------KTLGIILGAFIVCWLPFFIISLVLPI--CKDACWFHLAIFDFFTWLGYLNS 247

                  ....*....
gi 1835884573 315 ALNPILYNM 323
Cdd:cd15333   248 LINPIIYTM 256
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
79-173 2.13e-03

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 39.31  E-value: 2.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  79 LNLFCADLLFISAIPLVLAVRWTEA-WLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAV 157
Cdd:cd15157    40 LNLAVSDLMFVSTLPFRADYYLMGShWVFGDIACRIMSYSLYVNMYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARI 119
                          90
                  ....*....|....*.
gi 1835884573 158 LLALIWGYSAVAALPL 173
Cdd:cd15157   120 LCAVIWIFVMAASSPL 135
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
79-232 2.16e-03

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 39.36  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  79 LNLFCADLLFISAIPLvLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVhlqRGVRGPGRRARAVL 158
Cdd:cd15175    40 LNLALADILFLLTLPF-WAASAAKKWVFGEEMCKAVYCLYKMSFFSGMLLLMCISIDRYFAIV---QAASAHRHRSRAVF 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 159 L-----ALIWGYSAVAALPLCVFFRVVPQrlpgadQEISICTLIWPTIPG-EISWDVSFVTLNFLVPGLVIVISYSKILQ 232
Cdd:cd15175   116 IskvssLGVWVLAFILSIPELLYSGVNNN------DGNGTCSIFTNNKQTlSVKIQISQMVLGFLVPLVVMSFCYSVIIK 189
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
78-186 2.19e-03

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 39.37  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  78 VLNLFCADLLFISAIPL-VLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARA 156
Cdd:cd14988    39 ILNMAIADLGVVLTLPVwMLEVMLDYTWLWGSFLCKFTHYFYFANMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRR 118
                          90       100       110
                  ....*....|....*....|....*....|
gi 1835884573 157 VLLALIWGYSAVAALPLCVFFRVVPQRLPG 186
Cdd:cd14988   119 ALCAGIWVLSAIIPLPEVVHMQLLDGVEPM 148
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
49-231 2.26e-03

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 39.31  E-value: 2.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  49 LIFAVSLLGNVCALVLVARRRRRGATACLVL-NLFCADLLFISAIPLVLAVRWTEA-WLLGPVACHLLFYVMTLSGSVTI 126
Cdd:cd15161     9 LVFILAFPGNTLALWLFIHDRKSGTPSNVFLmHLAVADLSYVLILPMRLVYHLSGNhWPFGEVPCRLAGFLFYLNMYASL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 127 LTLAAVSLERMVCIVHLQRGVRgpGRRAR--AVLLALIWGYSAVAALPLCvffrVVPQRLpgADQEISICTLIWPTIPGE 204
Cdd:cd15161    89 YFLACISVDRFLAIVHPVKSMK--IRKPLyaHVVCGFLWVIVTVAMAPLL----VSPQTV--EVNNTTVCLQLYREKASR 160
                         170       180
                  ....*....|....*....|....*..
gi 1835884573 205 ISwdVSFVTLNFLVPGLVIVISYSKIL 231
Cdd:cd15161   161 GA--LVSLAVAFTIPFVTTVTCYLLII 185
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
74-334 2.29e-03

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 39.18  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLFISAI-PLVLAVRWTE-AWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCI---VHLQRGVR 148
Cdd:cd15310    35 TNYLVVSLAVADLLVATLVmPWVVYLEVTGgVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVvmpVHYQHGTG 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 149 GPGRRARAVLLALIWGYSAVAALPLCVFFRVVpqrlpgadQEISICTLIWPtipgeiSWDVSFVTLNFLVPGLVIVISYS 228
Cdd:cd15310   115 QSSCRRVSLMITAVWVLAFAVSCPLLFGFNTT--------GDPTVCSISNP------DFVIYSSVVSFYLPFGVTLLVYV 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 229 KILQITKASRKRLtvslayseshqirvsqqdfrlfRTLFLLMVSFFIMWSPiiiTILLILIQNFKQDLVIWPSLFFWVVA 308
Cdd:cd15310   181 RIYVVLLREKKAT----------------------QMLAIVLGAFIVCWLP---FFLTHILNTHCQACHVPPELYSATTW 235
                         250       260
                  ....*....|....*....|....*.
gi 1835884573 309 FTFANSALNPILYnmTLCRNEWKKIF 334
Cdd:cd15310   236 LGYVNSALNPVIY--TTFNIEFRRAF 259
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
45-183 2.32e-03

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 39.51  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  45 TVLVLIFAVSLLGN-VCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEA-WLLGPVACHLLFYVMTLSG 122
Cdd:cd15377     5 AVYILVFITGFLGNsVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTdWIFGDAMCKLQRFIFHVNL 84
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1835884573 123 SVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQR 183
Cdd:cd15377    85 YGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRK 145
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
42-323 2.48e-03

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 39.29  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  42 VETTVLVLIFAVSLLGNVCALVLVARRR-RRGATACLVLNLFCADLLFISAIPLVLAVRWT---EAWLLGPVACHLLFYV 117
Cdd:cd14995     2 VATFLVLLICGVGIVGNIMVVLVVLRTRhMRTPTNCYLVSLAVADLMVLVAAGLPNEIESLlgpDSWIYGYAGCLLITYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 118 MTLSGSVTILTLAAVSLERMVCIVHLQRG-VRGPGRRARAVLLAlIWGYSAVAALPLcvFFRVVPQRLPGADQEISICTL 196
Cdd:cd14995    82 QYLGINASSLSITAFTIERYIAICHPMKAqFICTVSRAKKIICF-VWIFTSLYCSPW--LFLLDLSIKHYGDDIVVRCGY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 197 IWPTIPGEISWDVSFVtLNFLVPGLVIVISYSKILQITKASRKRLTVSLAyseshqirvsqqdfrlfrtlfLLMVSFFIM 276
Cdd:cd14995   159 KVSRHYYLPIYLADFV-LFYVIPLLLAIVLYGLIGRILFSSRKQVTKMLA---------------------VVVVLFALL 216
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1835884573 277 WSPIIITILLiliQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNM 323
Cdd:cd14995   217 WMPYRTLVVY---NSFASPPYLDLWFLLFCRTCIYLNSAINPILYNL 260
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
41-172 2.52e-03

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 39.36  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  41 AVETTVLVLIFAVSLLGNVCALVLVARRRRRG-ATACLVLNLFCADLL-FISAIPLV-LAVRWTEAWLLGPVACHLLFYV 117
Cdd:cd15005     1 ALKLTTLGLILCVSLAGNLLFSVLIVRDRSLHrAPYYFLLDLCLADGLrSLACFPFVmASVRHGSGWIYGALSCKVIAFL 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1835884573 118 MTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALP 172
Cdd:cd15005    81 AVLFCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFP 135
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
44-279 2.74e-03

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 39.09  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  44 TTVLVLIFAVSLLGNVCAL-VLVARRRRRGATACLVLNLFCADLLF-ISAIPLVLAVRWTEA---WLLGPVACHLLFYVM 118
Cdd:cd15006     3 TTVQVVIFVGSLLGNFMVLwSTCRTSVFKSVTNRFIKNLACSGICAsLVCVPFDIVLSASPHccwWIYTLLFCKVIKFLH 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 119 TLSGSVTILTLAAVSLERMVCIVH-LQRGVRGPGRRAravLLALIWGYSAVAALPLCVFFRVVPQrlpgadQEISICTLI 197
Cdd:cd15006    83 KVFCSVTVLSFAAIALDRYYSVLYpLERKISDAKSRD---LVIYIWAHAVVASVPVFAVTNVTDI------YAMSTCTES 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 198 WPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTVSLAYSESHQI----RVSQQDFRLFRTLFLLMVSF 273
Cdd:cd15006   154 WGYSLGHLVYVIIYNITTVILPVAVVFLFMILIRRALSASQKKKVIIAALRTPQNTisipYVSQREAELHAMLLSMVLVF 233

                  ....*.
gi 1835884573 274 FIMWSP 279
Cdd:cd15006   234 ILCSVP 239
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
74-183 2.91e-03

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 39.09  E-value: 2.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLFISAIPLvLAVRWTEA--WLLGPVACHL---LFYVmTLSGSvtILTLAAVSLERMVCIVH-LQRGV 147
Cdd:cd15379    35 TTIYMLNLATADLLYVCSLPL-LIYNYTQKdyWPFGDFTCRLvrfQFYT-NLHGS--ILFLTCISVQRYLGICHpLASWH 110
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1835884573 148 RGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQR 183
Cdd:cd15379   111 KKKGKKLTWLVCGAVWLVVIAQCLPTFVFASTGTQR 146
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
77-334 2.94e-03

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 38.79  E-value: 2.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVH-LQRGVRGPGRRA 154
Cdd:cd15297    38 FLFSLACADLIIgVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKpLTYPVKRTTKMA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 155 rAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTipgeiswdVSFVT--LNFLVPGLVIVISYskiLQ 232
Cdd:cd15297   118 -GMMIAAAWVLSFILWAPAILFWQFIVGGRTVPEGECYIQFFSNAA--------VTFGTaiAAFYLPVIIMTVLY---WQ 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 233 ITKASRKRLTVSlayseshqirvsqqdfrlfRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWpSLFFWVVaftFA 312
Cdd:cd15297   186 ISRASSREKKVT-------------------RTILAILLAFIITWTPYNVMVLINTFCASCIPNTVW-TIGYWLC---YI 242
                         250       260
                  ....*....|....*....|..
gi 1835884573 313 NSALNPILYnmTLCRNEWKKIF 334
Cdd:cd15297   243 NSTINPACY--ALCNATFKKTF 262
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
74-236 3.07e-03

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 39.01  E-value: 3.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLFISAIPLVLAVRWT-EAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVH--LQRGVrgP 150
Cdd:cd15371    34 TAIFYANLAISDLLFCITLPFKIVYHLNgNNWVFGETMCRIITITFYGNMYCSILLLTCISINRYLAIVHpfIYRSL--P 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 151 GRRARAVLLALIWGYSAVAALPLCvffrVVPQRLPGADQEISICTLIWPT----IPGEISWDVSFVTLNFLVPGLVIVIS 226
Cdd:cd15371   112 KKTYAVLICALVWTIVFLYMLPFF----ILKQTYYLKELNITTCHDVLPEceqnSNFQFYYFISMAVFGFLIPLVITIFC 187
                         170
                  ....*....|
gi 1835884573 227 YSKILQITKA 236
Cdd:cd15371   188 YISIIRTLNA 197
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
73-324 3.20e-03

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 38.99  E-value: 3.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  73 ATACLVLNLFCADLLFISAIPLVLAVRWTE-AWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPG 151
Cdd:cd15968    34 RTAIYMVNLALADLLYALSLPLLIYNYAMRdRWLFGDFMCRLVRFLFYFNLYGSILFLTCISVHRYLGICHPMRPWHKET 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 152 RRARAVLLALIWGYSAVAALPLCVFFRVvpqrlpGADQEISICTLIWP--TIPGEISWDVSFVTLNFLVPGLVIVISYSK 229
Cdd:cd15968   114 RRAAWLTCVLVWILVFAQTLPILIFART------GIIRNRTVCYDLAPpaLFPHYVPYGMALTVSGFLLPFSIILWCYCL 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 230 IL----------QITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSffimwspiIITILLILIQNFKQDLVIW 299
Cdd:cd15968   188 VVrtlcrtlgpaEPPAQARRRKSIRTIVTVTLLFALCFLPFHITRTIYLAVRV--------TPGVPCHVLEAVAACYKIT 259
                         250       260
                  ....*....|....*....|....*
gi 1835884573 300 PSLffwvvafTFANSALNPILYNMT 324
Cdd:cd15968   260 RPL-------ASANSVLNPLLYFLT 277
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
74-232 3.34e-03

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 38.97  E-value: 3.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLFISAIP-LVLAVRWTEAWLLGPVACHLL--FYVMTLSGSVTILTlaAVSLERMVCIVHLQRGVRGP 150
Cdd:cd16001    35 STIYLVNLAVADLLYVCSLPlLIVNYAMRDRWPFGDFLCKLVrfLFYTNLYGSILFLT--CISVHRFLGVCYPIRSLAYR 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 151 GRRARAVLLALIWGYSAVAALPLCVFFRVvpqrlpGADQEISICTLIwpTIPGEIS----WDVSFVTLNFLVPGLVIVIS 226
Cdd:cd16001   113 TRRLAVIGSAATWILVVLQLLPTLVYART------GSINNRTVCYDL--TSPDNFGnyfpYGMVLTVTGFLIPFLIILLC 184

                  ....*.
gi 1835884573 227 YSKILQ 232
Cdd:cd16001   185 YCLMIK 190
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
77-321 3.35e-03

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 38.97  E-value: 3.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCAD-LLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRAR 155
Cdd:cd15317    38 LVLSLATADfLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 156 AVLLALIWGYSAVAALPLcVFFRVVPQRLPGADQEISI---CTLIWPTIPGEISwdvsfvTLNFLVPGLVIVISYSKILQ 232
Cdd:cd15317   118 WRFIAIGWLVPGIYTFGL-IYTGANDEGLEEYSSEISCvggCQLLFNKIWVLLD------FLTFFIPCLIMIGLYAKIFL 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 233 ITKASRKRLTVS---LAYSESHQIRVSQ-QDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSlFFWvva 308
Cdd:cd15317   191 VARRQARKIQNMedkFRSSEENSSKASAsRERKAAKTLAIVMGIFLFCWLPYFIDTIVDEYSNFITPAIVFDA-VIW--- 266
                         250
                  ....*....|...
gi 1835884573 309 FTFANSALNPILY 321
Cdd:cd15317   267 LGYFNSAFNPFIY 279
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
80-237 3.42e-03

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 38.62  E-value: 3.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  80 NLFCADLLFISAIPLVLAVRWT-EAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVL 158
Cdd:cd15370    41 NLALADLLFVIWFPLKIAYHINgNNWIYGEALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMSHSRKKANIAIGIS 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 159 LAlIWGYSAVAALPLcvffRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLN---FLVPGLVIVISYSKILQITK 235
Cdd:cd15370   121 LA-IWLLILLVTIPL----YLVKQTVFIPALDITTCHDVLPEQLLVGDMFNYFLSLAigvFLFPAFLTAVAYVLMIRALK 195

                  ..
gi 1835884573 236 AS 237
Cdd:cd15370   196 SS 197
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
79-237 3.61e-03

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 38.59  E-value: 3.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  79 LNLFCADLLFISAIPLVLAVRWT-EAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAV 157
Cdd:cd15369    40 LNLACADLLFVLLLPFKIAYHFSgNDWLFGEAMCRVVTAAFYCNMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRRASF 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 158 LLALIWGYSAVAALPLCVffRVVPQRLPGADqeISIC--TLIWPTIPGEISWDVS-FVTLNFLVPGLVIVISYSKILQIT 234
Cdd:cd15369   120 TCAAIWLLSIAGVVPLLL--SEQTIQIPDLG--ITTChdVLNEQLLMGYYVYYFSiFSCLFFFVPLIITTVCYVSIIRCL 195

                  ...
gi 1835884573 235 KAS 237
Cdd:cd15369   196 SSS 198
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
78-334 3.86e-03

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 38.56  E-value: 3.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  78 VLNLFCADLLFISAI-PLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARA 156
Cdd:cd15050    39 IVSLSVADLIVGAVVmPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRAS 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 157 VLLALIWGYSAVAALPLC---VFFRVVPQRLPGADQEISICTLIWptipgeisWDVSFVTLNFLVPGLVIVISYSKILQI 233
Cdd:cd15050   119 LMISGAWLLSFLWVIPILgwhHFARGGERVVLEDKCETDFHDVTW--------FKVLTAILNFYIPSLLMLWFYAKIFKA 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 234 TKASRKRLtvslayseshqirvsqqdfrlfRTLFLLMVSFFIMWSPIIITILLILiqnFKQDLViWPSLFFWVVAFTFAN 313
Cdd:cd15050   191 VNRERKAA----------------------KQLGFIMAAFILCWIPYFILFMVIA---FCKNCC-NENLHMFTIWLGYIN 244
                         250       260
                  ....*....|....*....|.
gi 1835884573 314 SALNPILYnmTLCRNEWKKIF 334
Cdd:cd15050   245 STLNPFIY--PLCNENFKKTF 263
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
209-334 4.19e-03

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 38.65  E-value: 4.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 209 VSFVTLNFLVPGLVIVISYSKILQITKASRKRLTVSlayseshqiRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLIL 288
Cdd:cd15345   158 VAFCISIFIAILVAIVILYARIYILVKSSSRRVTNH---------RNSERSMALLRTVVIVVGVFIACWSPLFILLLIDV 228
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1835884573 289 IQNFKQDLVIWPSLffWVVAFTFANSALNPILYnmTLCRNEWKKIF 334
Cdd:cd15345   229 ACEVKQCPILYKAD--WFIALAVLNSAMNPIIY--TLASKEMRRAF 270
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
104-323 4.73e-03

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 38.29  E-value: 4.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 104 WLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLcvFFRVVPQR 183
Cdd:cd15355    71 WAFGDAACRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAIPM--LFTMGEQN 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 184 LPGADQEISICTLIWPTIPGEISWDVSfVTLNFLVPGLVI-----VISYSKILQITKASRKRL--------TVSLAYSES 250
Cdd:cd15355   149 RSGTHPGGLICTPIVDTSTLKVVIQVN-AFLSFLFPMLVIsvlntLIANQLTVMVNQAEQENQvctiggqrTVLSVSMEP 227
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1835884573 251 HQIRVSQQDFRLFRTLfllMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFT----FANSALNPILYNM 323
Cdd:cd15355   228 GRVQSLRHGVLVLRAV---VIAFVVCWLPYHVRRLMFCYVSDEQWTTFLYDFYHYFYMLTnvlfYVSSAINPILYNL 301
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
47-321 5.85e-03

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 38.06  E-value: 5.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  47 LVLIFAVSLLGN--VCALVLVARRRRRGATACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVaCHLLFYVMTLSGS 123
Cdd:cd15320     8 LSVLILSTLLGNtlVCAAVIRFRHLRSKVTNFFVISLAVSDLLVaVLVMPWKAVAEIAGFWPFGSF-CNIWVAFDIMCST 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 124 VTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWgysavaalPLCVFFRVVPQRL------PGADQEISICTLI 197
Cdd:cd15320    87 ASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAW--------TLSVLISFIPVQLnwhkakPTSFLDLNASLRD 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 198 WPTIPGEIS----WDVSFVTLNFLVPGLVIVISYSKILQITKASRKRLTVSLAYSESHQIRVS----------------- 256
Cdd:cd15320   159 LTMDNCDSSlnrtYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQNstgnrgsgdcqqpessf 238
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1835884573 257 ----QQDFRLFRTLFLLMVSFFIMWSPIIIT--ILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILY 321
Cdd:cd15320   239 kmsfKRETKVLKTLSVIMGVFVCCWLPFFILncMVPFCKPTSTEPFCISSTTFDVFVWFGWANSSLNPIIY 309
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
217-321 5.95e-03

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 38.00  E-value: 5.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 217 LVPGLVIVISYSKILQItkASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLiliQNFKQDL 296
Cdd:cd14968   175 LVPLLIMLVIYLRIFRV--IRKQLRQIESLLRSRRSRSTLQKEVKAAKSLAIILFLFALCWLPLHIINCI---TLFCPEC 249
                          90       100
                  ....*....|....*....|....*
gi 1835884573 297 VIWPSLFFWVVAFTFANSALNPILY 321
Cdd:cd14968   250 KVPKILTYIAILLSHANSAVNPIVY 274
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
77-243 6.00e-03

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 37.83  E-value: 6.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLFIS-AIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVH-LQRGVRGpgrRA 154
Cdd:cd15398    38 LIGNLAFSDILVVLfCSPFTLTCVLLDQWIFGEVMCHIVPFLQCVSVMVSTLMLMSIAIVRYHMIKHpLSNHLTA---NH 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 155 RAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEIS---ICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKIL 231
Cdd:cd15398   115 GYFLLGTVWTLGFTICSPLPVFHKIVDLSETFNLESLKnkyLCIESWPSDSYRIAFTISLLFVQYILPLVCLTVSHTSVC 194
                         170
                  ....*....|....*
gi 1835884573 232 QITKASRK---RLTV 243
Cdd:cd15398   195 RSVKRSRSvfyRLTI 209
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
77-321 6.50e-03

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 37.92  E-value: 6.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLL---FISAIPLVLAVrwTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRR 153
Cdd:cd15084    48 ILVNLAVADLLvtlFGSSVSFSNNI--VGFFVFGKTMCEFEGFMVSLTGIVGLWSLAILAFERYLVICKPMGDFRFQQRH 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 154 ArAVLLALIWGYSAV-AALPLCVFFRVVPQRLPGAdqeisiCTLIWPT-IPGEISWDVSFVTLNFLVPGLVIVISYSKIL 231
Cdd:cd15084   126 A-VSGCAFTWGWSLLwTSPPLFGWSSYVPEGLRTS------CGPNWYTgGTNNNSYILALFVTCFALPLSTIIFSYSNLL 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 232 qitkasrkrLTVSLAYSESHQIRVSQQDFRLFRTLFLLMV-SFFIMWSPIIITILLILIQnfkQDLVIWPSLFFWVVAFT 310
Cdd:cd15084   199 ---------LTLRAVAAQQKESETTQRAEKEVTRMVIAMVmAFLICWLPYATFAMVVATN---KDVVIQPTLASLPSYFS 266
                         250
                  ....*....|.
gi 1835884573 311 FANSALNPILY 321
Cdd:cd15084   267 KTATVYNPIIY 277
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
74-321 6.59e-03

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 37.92  E-value: 6.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGR 152
Cdd:cd15957    35 TNYFITSLACADLVMgLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTK 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 153 RARAVLLALIWGYSAVAA-LPLCV-FFRVVPQRLPGADQEISICTLIwptipGEISWDVSFVTLNFLVPGLVIVISYSKI 230
Cdd:cd15957   115 NKARVIILMVWIVSGLTSfLPIQMhWYRATHQEAINCYAEETCCDFF-----TNQAYAIASSIVSFYVPLVIMVFVYSRV 189
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 231 LQITKASRKRLTVSLAYSESHQIRVSQQDFR---------------LFRTLFLLMVSFFIMWSPIIITILLILIqnfkQD 295
Cdd:cd15957   190 FQEAKRQLQKIDKSEGRFHNQNIDQNGSGGGggnrrrskfclkehkALKTLGIIMGTFTLCWLPFFIVNIVHVI----QD 265
                         250       260
                  ....*....|....*....|....*.
gi 1835884573 296 LVIWPSLFFWVVAFTFANSALNPILY 321
Cdd:cd15957   266 NLIRKEVYILLNWIGYVNSGFNPLIY 291
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
73-279 7.20e-03

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 37.86  E-value: 7.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  73 ATACLVLNLFCADLLFISAIP-LVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPG 151
Cdd:cd15374    34 PTTVYMFHLALSDTLYVLSLPtLIYYYADHNHWPFGVVACKIVRFLFYANLYCSILFLTCISVHRYVGICHPIRALRWVK 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 152 RRARAVLLALIWGYSAVAALPLCVFFRVVPQrlpgadQEISICTLIwpTIPGEISWDVSFVT----LNFLVPGLVIVISY 227
Cdd:cd15374   114 PRHAYLICASVWLVVTVCLVPNLIFVTTSRK------DNITLCHDT--TRPEEFDHYVHYSSavmvLLFGIPCLVIVVCY 185
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1835884573 228 SKIlqitkasRKRLTVSLAYSESHQIRVSQQdfRLFRTLFLLMVSFFIMWSP 279
Cdd:cd15374   186 GLM-------ARRLCKPRVGSSRQQGPSSKK--RSLKTIIMVLTVFAICFVP 228
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
74-321 8.86e-03

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 37.58  E-value: 8.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  74 TACLVLNLFCADLLF-ISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGR 152
Cdd:cd15327    35 TNYFIVNLAIADLLLsTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASILSLCVISVDRYVGVKHSLKYPTIMTE 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 153 RARAVLLALIWGYSAVAAL-PLCVFFRVVPQrlpgadqEISICTliwptIPGEISWDVSFVTLNFLVPGLVIVISYSKIL 231
Cdd:cd15327   115 RKAGVILVLLWVSSMVISIgPLLGWKEPPPP-------DESICS-----ITEEPGYALFSSLFSFYLPLMVILVMYFRVY 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 232 qitkasrkrlTVSLAYSeshqirvsqQDFRLFRTLFLLMVSFFIMWSPIIITILLiliQNFKQDLVIWPSLFFWVVAFTF 311
Cdd:cd15327   183 ----------VVALKFS---------REKKAAKTLAIVVGVFILCWFPFFFVLPL---GSFFPALKPSEMVFKVIFWLGY 240
                         250
                  ....*....|
gi 1835884573 312 ANSALNPILY 321
Cdd:cd15327   241 FNSCVNPIIY 250
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
77-231 9.46e-03

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 37.44  E-value: 9.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573  77 LVLNLFCADLLFISAIPLVLAVRWTEA-WLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRAR 155
Cdd:cd15368    38 FMINLSLTDLMLACFLPFQIVYHIQRNhWIFGKPLCNVVTVLFYANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835884573 156 AVLLALIWGYSAVAALPLcvffRVVPQRLPGADQEISIC--TLIWPTIPGEISWDVSFVTLN---FLVPGLVIVISYSKI 230
Cdd:cd15368   118 VAACIGMWLLVLTALSPL----ERTDLTYYVKELNITTCfdVLKWTMLPNIAAWAAFLFTLFillFLIPFIITVYCYVLI 193

                  .
gi 1835884573 231 L 231
Cdd:cd15368   194 I 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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