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Conserved domains on  [gi|62899645|sp|Q5M7U6|]
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RecName: Full=Actin-related protein 2; AltName: Full=Actin-like protein 2

Protein Classification

actin family protein( domain architecture ID 12199243)

actin family protein has well-characterized cytoskeletal functions and has also been implicated in nuclear activities

CATH:  3.30.420.40
Gene Ontology:  GO:0031491|GO:0006338
SCOP:  3000092

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ASKHA_NBD_Arp2 cd10220
nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, ...
7-388 0e+00

nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, also called actin-like protein 2, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp2 is encoded by the ACTR2 gene.


:

Pssm-ID: 466821  Cd Length: 381  Bit Score: 881.90  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   7 KVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMK 86
Cdd:cd10220   1 KVVVCDNGTGFVKCGFAGSNFPEHVFPSLVGRPILRAEEKVGDIEIKDIMVGDEASELRSMLEVTYPMENGIVRNWDDME 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  87 HLWDYTFGpEKLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHI 166
Cdd:cd10220  81 HLWDYTFG-EKLKIDPRECKILLTEPPMNPTKNREKMVEVMFEKYGFAGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHI 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 167 CPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTL 246
Cdd:cd10220 160 VPVYEGFSLPHLTRRLDVAGRDITRYLIKLLLLRGYAFNRTADFETVREIKEKLCYVAYDIELEQKLALETTVLVESYTL 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 247 PDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYL 326
Cdd:cd10220 240 PDGRVIKVGGERFEAPEALFQPHLIDVEGPGIAELLFNTIQAADIDTRPELYKHIVLSGGSTMYPGLPSRLEKEIKQLYL 319
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62899645 327 ERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEK 388
Cdd:cd10220 320 ERVLKGDTERLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDEFWITRQEYEEQGVRVLDK 381
 
Name Accession Description Interval E-value
ASKHA_NBD_Arp2 cd10220
nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, ...
7-388 0e+00

nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, also called actin-like protein 2, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp2 is encoded by the ACTR2 gene.


Pssm-ID: 466821  Cd Length: 381  Bit Score: 881.90  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   7 KVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMK 86
Cdd:cd10220   1 KVVVCDNGTGFVKCGFAGSNFPEHVFPSLVGRPILRAEEKVGDIEIKDIMVGDEASELRSMLEVTYPMENGIVRNWDDME 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  87 HLWDYTFGpEKLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHI 166
Cdd:cd10220  81 HLWDYTFG-EKLKIDPRECKILLTEPPMNPTKNREKMVEVMFEKYGFAGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHI 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 167 CPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTL 246
Cdd:cd10220 160 VPVYEGFSLPHLTRRLDVAGRDITRYLIKLLLLRGYAFNRTADFETVREIKEKLCYVAYDIELEQKLALETTVLVESYTL 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 247 PDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYL 326
Cdd:cd10220 240 PDGRVIKVGGERFEAPEALFQPHLIDVEGPGIAELLFNTIQAADIDTRPELYKHIVLSGGSTMYPGLPSRLEKEIKQLYL 319
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62899645 327 ERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEK 388
Cdd:cd10220 320 ERVLKGDTERLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDEFWITRQEYEEQGVRVLDK 381
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
6-388 0e+00

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 530.29  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645      6 RKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRsttKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDM 85
Cdd:smart00268   1 VPAIVIDNGSGTIKAGFAGEDFPQVVFPSIVGRPKDG---KGMVGDAKDIFVGDEAQEKRGGLELKYPIENGIVENWDDM 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645     86 KHLWDYTFGPEkLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTH 165
Cdd:smart00268  78 EKIWDYTFFNE-LRVEPEEHPVLLTEPPMNPKSNREKILEIMFETFNFPALYIAIQAVLSLYASGRTTGLVIDSGDGVTH 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645    166 ICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALE---TTVLVE 242
Cdd:smart00268 157 VVPVVDGYVLPHAIKRIDIAGRDITDYLKELLSERGYQFNSSAEFEIVREIKEKLCYVAEDFEKEMKLAREsseSSKLEK 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645    243 SYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELK 322
Cdd:smart00268 237 TYELPDGNTIKVGNERFRIPEILFSPELIGLEQKGIHELVYESIQKCDIDVRKDLYENIVLSGGSTLIPGFGERLEKELK 316
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62899645    323 QLYlervlkgdvekLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDnFWMTRQEYQEKGVRVLEK 388
Cdd:smart00268 317 QLA-----------PKKLKVKVIAPPERKYSVWLGGSILASLSTFED-MWITKKEYEESGSQIVER 370
PTZ00004 PTZ00004
actin-2; Provisional
1-382 1.01e-136

actin-2; Provisional


Pssm-ID: 240225 [Multi-domain]  Cd Length: 378  Bit Score: 395.29  E-value: 1.01e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645    1 MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPiiRSTTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVR 80
Cdd:PTZ00004   1 MSVEETNAAVVDNGSGMVKAGFAGDDAPRCVFPSIVGRP--KNPGIMVGMEEKDCYVGDEAQDKRGILTLKYPIEHGIVT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   81 NWDDMKHLWDYTFGPEkLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSG 160
Cdd:PTZ00004  79 NWDDMEKIWHHTFYNE-LRVAPEEHPVLLTEAPLNPKANREKMTQIMFETHNVPAMYVAIQAVLSLYASGRTTGIVLDSG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  161 DGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETT-V 239
Cdd:PTZ00004 158 DGVSHTVPIYEGYSLPHAIHRLDVAGRDLTEYMMKILHERGTTFTTTAEKEIVRDIKEKLCYIALDFDEEMGNSAGSSdK 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  240 LVESYTLPDGRIIKVGGERFEAPEALFQPHLINV-EGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLE 318
Cdd:PTZ00004 238 YEESYELPDGTIITVGSERFRCPEALFQPSLIGKeEPPGIHELTFQSINKCDIDIRKDLYGNIVLSGGTTMYRGLPERLT 317
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62899645  319 RELKQLylervlkgdveKLSKFKIRIEDPPRRKHMVFLGGAVLADiMKDKDNFWMTRQEYQEKG 382
Cdd:PTZ00004 318 KELTTL-----------APSTMKIKVVAPPERKYSVWIGGSILSS-LPTFQQMWVTKEEYDESG 369
Actin pfam00022
Actin;
8-388 5.51e-116

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 343.52  E-value: 5.51e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645     8 VVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPiirstTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKH 87
Cdd:pfam00022   3 ALVIDNGSHTTRAGFAGEDAPKAVIPSCVGKP-----RGTKVEAANKYYVGDEALTYRPGMEVRSPVEDGIVVDWDAMEE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645    88 LWDYTFGpEKLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHIC 167
Cdd:pfam00022  78 IWEHVLK-EELQVDPEEHPLLLTEPPWNPPANREKAAEIMFEKFGVPALYLAKNPVLSAFASGRTTGLVVDSGAGVTSVV 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   168 PVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLR------------------------------GYAFNHSADFETVRMIK 217
Cdd:pfam00022 157 PVHDGYVLQKAIRRSDLGGDFLTDYLRELLRSRnieitprylikskkpgdpapavtkrelpdtTYSYKTYQERRVLEEIK 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   218 EKLCYVGYNIEQEQKLAleTTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEG--------VGVAELLFNTIQAA 289
Cdd:pfam00022 237 ESVCYVSDDPFGDETTS--SSIPTRVYELPDGSTIILGAERFRVPEILFNPSLIGSESelpppqtaVGIPELIVDAINAC 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   290 DIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLylerVLKGdveklskFKIRI---EDPPRRKHMVFLGGAVLADImk 366
Cdd:pfam00022 315 DVDLRPSLLANIVVTGGNSLFPGFTERLEKELAQL----APPG-------VKVKIiapGNTVERRYSAWIGGSILASL-- 381
                         410       420
                  ....*....|....*....|....*
gi 62899645   367 dkDNF---WMTRQEYQEKGVRVLEK 388
Cdd:pfam00022 382 --GTFqqmWVSKQEYEEHGASVVER 404
COG5277 COG5277
Actin-related protein [Cytoskeleton];
1-380 3.88e-63

Actin-related protein [Cytoskeleton];


Pssm-ID: 444088  Cd Length: 424  Bit Score: 208.49  E-value: 3.88e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   1 MDSQGRK--VVVCDNGTGFVKCG-YAGSNFPEHI-----FPALVGRPIIRsttkvGNIEI--KDLMVGDEASELRSMLE- 69
Cdd:COG5277   1 MSDAYKLkyVIGIDFGTSYVKYGpIALEEKPRVIqtrglFLRIVGESKLL-----GPMEGlsRGLVVGDEVSKYLSSVRd 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  70 ----VNYPMENGIVR-----NWDDMKHLWDYTFGPEKL-NIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSG---V 136
Cdd:COG5277  76 airnLKYPLRDGIVRrddedAWRVLKELLRYTFAQFLVvDPEFHGFLVVVALSALAPDYMRERLFDIHFEVFSEEGapaV 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 137 YVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGfSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADfETVRMI 216
Cdd:COG5277 156 TIIPQPLAVAIAEKAVTCVVVEAGHGNSQVAPISRG-PIREGLVALNRGGAEANAITREILKDRGYSDTAREE-YVVRVV 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 217 KEKLCYVGYNIEQE-QKLALETTVLVESYTLPDGRIIKVGGE----RFEAPEALFQPHLINVEG---------------- 275
Cdd:COG5277 234 KEALGLVPRDLAKAiQKAASNPDSFEAKVRLPNPTVEIELGNyaweRFLIGEILFNPNHEGFESyiqqgrlriedavigd 313
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 276 ------VGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMY---PGL-------PSRLERELKQLYLErvlkgdveklsk 339
Cdd:COG5277 314 vvlygeMGLAEAIINSIMKCDVEIQDELYSNIILSGGAFNWsvpPGLedvavdsVTRVQIELSELAPE------------ 381
                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 62899645 340 FKIRIEDPPRRKHMVFLGGAVLADIMKDKDNF-WMTRQEYQE 380
Cdd:COG5277 382 LKVNVRLVSDPQYSVWKGAIIYGYALPFSVKWsWITKEGWYF 423
 
Name Accession Description Interval E-value
ASKHA_NBD_Arp2 cd10220
nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, ...
7-388 0e+00

nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, also called actin-like protein 2, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp2 is encoded by the ACTR2 gene.


Pssm-ID: 466821  Cd Length: 381  Bit Score: 881.90  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   7 KVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMK 86
Cdd:cd10220   1 KVVVCDNGTGFVKCGFAGSNFPEHVFPSLVGRPILRAEEKVGDIEIKDIMVGDEASELRSMLEVTYPMENGIVRNWDDME 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  87 HLWDYTFGpEKLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHI 166
Cdd:cd10220  81 HLWDYTFG-EKLKIDPRECKILLTEPPMNPTKNREKMVEVMFEKYGFAGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHI 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 167 CPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTL 246
Cdd:cd10220 160 VPVYEGFSLPHLTRRLDVAGRDITRYLIKLLLLRGYAFNRTADFETVREIKEKLCYVAYDIELEQKLALETTVLVESYTL 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 247 PDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYL 326
Cdd:cd10220 240 PDGRVIKVGGERFEAPEALFQPHLIDVEGPGIAELLFNTIQAADIDTRPELYKHIVLSGGSTMYPGLPSRLEKEIKQLYL 319
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62899645 327 ERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEK 388
Cdd:cd10220 320 ERVLKGDTERLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDEFWITRQEYEEQGVRVLDK 381
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
6-388 0e+00

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 530.29  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645      6 RKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRsttKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDM 85
Cdd:smart00268   1 VPAIVIDNGSGTIKAGFAGEDFPQVVFPSIVGRPKDG---KGMVGDAKDIFVGDEAQEKRGGLELKYPIENGIVENWDDM 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645     86 KHLWDYTFGPEkLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTH 165
Cdd:smart00268  78 EKIWDYTFFNE-LRVEPEEHPVLLTEPPMNPKSNREKILEIMFETFNFPALYIAIQAVLSLYASGRTTGLVIDSGDGVTH 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645    166 ICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALE---TTVLVE 242
Cdd:smart00268 157 VVPVVDGYVLPHAIKRIDIAGRDITDYLKELLSERGYQFNSSAEFEIVREIKEKLCYVAEDFEKEMKLAREsseSSKLEK 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645    243 SYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELK 322
Cdd:smart00268 237 TYELPDGNTIKVGNERFRIPEILFSPELIGLEQKGIHELVYESIQKCDIDVRKDLYENIVLSGGSTLIPGFGERLEKELK 316
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62899645    323 QLYlervlkgdvekLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDnFWMTRQEYQEKGVRVLEK 388
Cdd:smart00268 317 QLA-----------PKKLKVKVIAPPERKYSVWLGGSILASLSTFED-MWITKKEYEESGSQIVER 370
ASKHA_NBD_actin_Arp-T1-3 cd13397
nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar ...
8-382 2.41e-164

nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar proteins; The family includes actin and human actin-related proteins T1, T2, and T3. Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Arp-T1, encoded by ACTRT1/ARPT1 gene expressed in testis, negatively regulates the Hedgehog (SHH) signaling, binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression. Arp-T2 (also called actin-related protein M2; encoded by ACTRT2/ARPM2 gene expressed in testis and various other cell types) and Arp-T3 (also called actin-related protein M1; encoded by ACTRT3/ARPM1 gene expressed in all tested human tissues) play general roles in the organization of the cytoskeleton like other cytoplasmic actin-related proteins.


Pssm-ID: 466848 [Multi-domain]  Cd Length: 359  Bit Score: 464.74  E-value: 2.41e-164
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   8 VVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTkVGNIEiKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKH 87
Cdd:cd13397   2 AVVIDNGSGLIKAGFAGEDLPRAVFPSVVGRPKYKAVM-LGAGQ-KEVYVGDEAQEKRGVLTLSYPIEHGIVTNWDDMEK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  88 LWDYTFgPEKLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHIC 167
Cdd:cd13397  80 IWHHTF-ENELRVKPEEHPVLLTEAPLNPKQNREKMAEIMFETFGVPAFYVAIQAVLSLYSSGRTTGLVLDSGDGVTHTV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 168 PVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEqkLALETTVLVESYTLP 247
Cdd:cd13397 159 PIYEGYALPHAVQRLDLAGRDLTEYLMKLLKERGHSFTTTAEREIVRDIKEKLCYVALDYEEE--LKKKSEELEKEYTLP 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 248 DGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLE 327
Cdd:cd13397 237 DGQVIKIGSERFRCPEALFRPSLIGREAPGIHKLVYNSIMKCDIDIRKDLYSNIVLSGGSTMFPGLPERLQKELEALAPS 316
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*
gi 62899645 328 RVlkgdveklskfKIRIEDPPRRKHMVFLGGAVLADIMKDKDNfWMTRQEYQEKG 382
Cdd:cd13397 317 ST-----------KVKVIAPPERKYSVWIGGSILASLSTFKSM-WITRAEYDEFG 359
ASKHA_NBD_actin cd10224
nucleotide-binding domain (NBD) of actin and similar proteins; Actin is a ubiquitous protein ...
9-382 1.90e-156

nucleotide-binding domain (NBD) of actin and similar proteins; Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Actin is a monomeric globular protein (G-actin) that reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. At low salt concentrations, actin exists as a monomer, and as the salt concentration rises F-actin forms, with the consequent hydrolysis of ATP. F-actin assembly is in constant flux with G-actin association occurring at the barbed end (+) and its disassociation at the pointed end (-). Actin monomers that have been released from the pointed end can be reused, if the ADP is exchanged for ATP. F-actin filaments can assemble into higher order structures, for example branched F-actin, and stress fibers. Actin binding proteins regulate actin filament dynamics by a range of functions including actin severing, depolymerizing, capping, stabilizing and de novo actin polymerization. Actins interaction with myosin is the basis of muscular contraction and many aspects of cell motility. In vertebrates there are three main groups of actin isoforms, alpha, beta and gamma. The alpha actins found in muscle tissues are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. In plants there are many isoforms which are probably involved in a variety of functions such as cytoplasmic streaming, cell shape determination, tip growth, graviperception, cell wall deposition, etc.


Pssm-ID: 466823  Cd Length: 365  Bit Score: 444.89  E-value: 1.90e-156
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   9 VVCDNGTGFVKCGYAGSNFPEHIFPALVGRPiiRSTTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHL 88
Cdd:cd10224   3 LVVDNGSGMCKAGFAGDDAPRAVFPSIVGRP--RHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  89 WDYTFGPEkLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICP 168
Cdd:cd10224  81 WHHTFYNE-LRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 169 VYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPD 248
Cdd:cd10224 160 IYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMQTAASSSSLEKSYELPD 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 249 GRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLyler 328
Cdd:cd10224 240 GQVITIGNERFRCPEALFQPSFLGMEAAGIHETTYNSIMKCDVDIRKDLYANIVLSGGTTMFPGIADRMQKEITAL---- 315
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....
gi 62899645 329 vlkgdveKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKdNFWMTRQEYQEKG 382
Cdd:cd10224 316 -------APSTMKIKIVAPPERKYSVWIGGSILASLSTFQ-QMWISKQEYDESG 361
ASKHA_NBD_Arp1 cd10216
nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, ...
9-388 8.79e-156

nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, also called centractin, actin-like protein, alpha-centractin, actin-RPV, or centrosome-associated actin homolog, may be a component of a multi-subunit centrosomal complex involved in microtubule-based vesicle motility. In yeast, actin-related protein is essential for viability and is associated with the centrosome. In vertebrates, Arp1 is a core component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding. The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. ARP1 forms the backbone filament of the dynactin rod structure and serves as the scaffold for the remaining subunits. It is required for proper orientation of the mitotic spindle. Arp1 is the only actin-related protein known to form actin-like filaments. Human Arp1/centractin is encoded by the ACTR1A gene.


Pssm-ID: 466820 [Multi-domain]  Cd Length: 370  Bit Score: 443.53  E-value: 8.79e-156
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   9 VVCDNGTGFVKCGYAGSNFPEHIFPALVGRPiirSTTKV--GNIEiKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMK 86
Cdd:cd10216   4 VVIDNGSGVIKAGFAGDDIPKVVFPSYVGRP---KHVRVmaGALE-GDVFVGPKAEEHRGLLKIRYPMEHGIVTDWNDME 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  87 HLWDYTFGPEKLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHI 166
Cdd:cd10216  80 RIWQYVYSKLQLNTFSEEHPVLLTEAPLNPRKNREKAAEVFFETFNVPALFVSMQAVLSLYASGRTTGVVLDSGDGVTHA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 167 CPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVeSYTL 246
Cdd:cd10216 160 VPIYEGFALPHSIRRVDIAGRDVTEYLQLLLRKSGYNFHTSAEFEIVREIKEKACYVALNPQKEEKLEEEKTEKA-QYTL 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 247 PDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKqlyl 326
Cdd:cd10216 239 PDGSTIEIGPERFRAPEILFNPELIGLEYPGVHEVLVDSIQKSDLDLRKTLYSNIVLSGGSTLFKGFGDRLLSEVK---- 314
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62899645 327 eRVLKGDVeklskfKIRIEDPPRRKHMVFLGGAVLADImkdkDNF---WMTRQEYQEKGVRVLEK 388
Cdd:cd10216 315 -KLAPKDV------KIRISAPPERLYSTWIGGSILASL----STFkkmWVSKKEYEEDGARILHR 368
PTZ00004 PTZ00004
actin-2; Provisional
1-382 1.01e-136

actin-2; Provisional


Pssm-ID: 240225 [Multi-domain]  Cd Length: 378  Bit Score: 395.29  E-value: 1.01e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645    1 MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPiiRSTTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVR 80
Cdd:PTZ00004   1 MSVEETNAAVVDNGSGMVKAGFAGDDAPRCVFPSIVGRP--KNPGIMVGMEEKDCYVGDEAQDKRGILTLKYPIEHGIVT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   81 NWDDMKHLWDYTFGPEkLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSG 160
Cdd:PTZ00004  79 NWDDMEKIWHHTFYNE-LRVAPEEHPVLLTEAPLNPKANREKMTQIMFETHNVPAMYVAIQAVLSLYASGRTTGIVLDSG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  161 DGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETT-V 239
Cdd:PTZ00004 158 DGVSHTVPIYEGYSLPHAIHRLDVAGRDLTEYMMKILHERGTTFTTTAEKEIVRDIKEKLCYIALDFDEEMGNSAGSSdK 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  240 LVESYTLPDGRIIKVGGERFEAPEALFQPHLINV-EGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLE 318
Cdd:PTZ00004 238 YEESYELPDGTIITVGSERFRCPEALFQPSLIGKeEPPGIHELTFQSINKCDIDIRKDLYGNIVLSGGTTMYRGLPERLT 317
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62899645  319 RELKQLylervlkgdveKLSKFKIRIEDPPRRKHMVFLGGAVLADiMKDKDNFWMTRQEYQEKG 382
Cdd:PTZ00004 318 KELTTL-----------APSTMKIKVVAPPERKYSVWIGGSILSS-LPTFQQMWVTKEEYDESG 369
PTZ00281 PTZ00281
actin; Provisional
1-388 6.59e-130

actin; Provisional


Pssm-ID: 173506 [Multi-domain]  Cd Length: 376  Bit Score: 378.27  E-value: 6.59e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645    1 MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPiiRSTTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVR 80
Cdd:PTZ00281   1 MDGEDVQALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRP--RHTGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   81 NWDDMKHLWDYTFGPEkLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSG 160
Cdd:PTZ00281  79 NWDDMEKIWHHTFYNE-LRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  161 DGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVL 240
Cdd:PTZ00281 158 DGVSHTVPIYEGYALPHAILRLDLAGRDLTDYMMKILTERGYSFTTTAEREIVRDIKEKLAYVALDFEAEMQTAASSSAL 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  241 VESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERE 320
Cdd:PTZ00281 238 EKSYELPDGQVITIGNERFRCPEALFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYGNVVLSGGTTMFPGIADRMNKE 317
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62899645  321 LKQLylervlkgdveKLSKFKIRIEDPPRRKHMVFLGGAVLADiMKDKDNFWMTRQEYQEKGVRVLEK 388
Cdd:PTZ00281 318 LTAL-----------APSTMKIKIIAPPERKYSVWIGGSILAS-LSTFQQMWISKEEYDESGPSIVHR 373
PTZ00466 PTZ00466
actin-like protein; Provisional
9-388 2.59e-123

actin-like protein; Provisional


Pssm-ID: 240426 [Multi-domain]  Cd Length: 380  Bit Score: 361.57  E-value: 2.59e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645    9 VVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTkVGNIEiKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHL 88
Cdd:PTZ00466  15 IIIDNGTGYIKAGFAGEDVPNLVFPSYVGRPKYKRVM-AGAVE-GNIFVGNKAEEYRGLLKVTYPINHGIIENWNDMENI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   89 WDYTFGPEKLNIDTRSckILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICP 168
Cdd:PTZ00466  93 WIHVYNSMKINSEEHP--VLLTEAPLNPQKNKEKIAEVFFETFNVPALFISIQAILSLYSCGKTNGTVLDCGDGVCHCVS 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  169 VYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEqKLALETTVLVESYTLPD 248
Cdd:PTZ00466 171 IYEGYSITNTITRTDVAGRDITTYLGYLLRKNGHLFNTSAEMEVVKNMKENCCYVSFNMNKE-KNSSEKALTTLPYILPD 249
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  249 GRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLER 328
Cdd:PTZ00466 250 GSQILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLRRTLYSHIVLSGGTTMFHGFGDRLLNEIRKFAPKD 329
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  329 VlkgdveklskfKIRIEDPPRRKHMVFLGGAVLADIMKDKdNFWMTRQEYQEKGVRVLEK 388
Cdd:PTZ00466 330 I-----------TIRISAPPERKFSTFIGGSILASLATFK-KIWISKQEFDEYGSVILHR 377
Actin pfam00022
Actin;
8-388 5.51e-116

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 343.52  E-value: 5.51e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645     8 VVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPiirstTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKH 87
Cdd:pfam00022   3 ALVIDNGSHTTRAGFAGEDAPKAVIPSCVGKP-----RGTKVEAANKYYVGDEALTYRPGMEVRSPVEDGIVVDWDAMEE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645    88 LWDYTFGpEKLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHIC 167
Cdd:pfam00022  78 IWEHVLK-EELQVDPEEHPLLLTEPPWNPPANREKAAEIMFEKFGVPALYLAKNPVLSAFASGRTTGLVVDSGAGVTSVV 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   168 PVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLR------------------------------GYAFNHSADFETVRMIK 217
Cdd:pfam00022 157 PVHDGYVLQKAIRRSDLGGDFLTDYLRELLRSRnieitprylikskkpgdpapavtkrelpdtTYSYKTYQERRVLEEIK 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   218 EKLCYVGYNIEQEQKLAleTTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEG--------VGVAELLFNTIQAA 289
Cdd:pfam00022 237 ESVCYVSDDPFGDETTS--SSIPTRVYELPDGSTIILGAERFRVPEILFNPSLIGSESelpppqtaVGIPELIVDAINAC 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   290 DIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLylerVLKGdveklskFKIRI---EDPPRRKHMVFLGGAVLADImk 366
Cdd:pfam00022 315 DVDLRPSLLANIVVTGGNSLFPGFTERLEKELAQL----APPG-------VKVKIiapGNTVERRYSAWIGGSILASL-- 381
                         410       420
                  ....*....|....*....|....*
gi 62899645   367 dkDNF---WMTRQEYQEKGVRVLEK 388
Cdd:pfam00022 382 --GTFqqmWVSKQEYEEHGASVVER 404
ASKHA_NBD_actin-like cd10169
nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ...
9-382 1.36e-111

nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ubiquitous in eukaryotes, and the major component of the actin cytoskeleton; monomeric globular protein (G-actin) reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. F-actin filaments form with the consequent hydrolysis of ATP. Some actin-related proteins (Arps) have roles in cytoskeletal functions, such as actin polymerization (Arp2/3) and dynein motor activity (Arp1). Both conventional actin and specific Arps have been implicated in chromatin remodeling and/or transcription regulation. The actin/ARP family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466810 [Multi-domain]  Cd Length: 258  Bit Score: 326.76  E-value: 1.36e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   9 VVCDNGTGFVKCGYAGSNFPEHIFPalvgrpiirsttkvgnieikdlmvgdeaselrsmlevnypmengivrnWDDMKHL 88
Cdd:cd10169   1 IVIDNGSGTIKAGFAGEDAPRLIFP------------------------------------------------WDDMEKI 32
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  89 WDYTFGPEkLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICP 168
Cdd:cd10169  33 WEHVFYNL-LRVDPEEHPVLLTEPPLNPKANREKLAEILFETFNVPSLYIANQAVLSLYASGRTTGLVVDSGEGVTHIVP 111
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 169 VYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCyvgynieqeqklalettvlvesytlpd 248
Cdd:cd10169 112 VYEGYVLPHAVRRLDIGGRDLTDYLAKLLREKGYSFSTSAEREIVRDIKEKLC--------------------------- 164
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 249 griikvggerfeapealfqphlinvegvGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYler 328
Cdd:cd10169 165 ----------------------------GLHELIYDSIMKCDIDLRKELYSNIVLSGGTTLFPGFAERLQKELSKLA--- 213
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....
gi 62899645 329 vlkgdvekLSKFKIRIEDPPRRKHMVFLGGAVLADiMKDKDNFWMTRQEYQEKG 382
Cdd:cd10169 214 --------PSSVKVKVIAPPERKYSAWIGGSILAS-LSTFQQMWITKEEYEEHG 258
ASKHA_NBD_ACTL7 cd10214
nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ...
7-382 1.80e-102

nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ACTL7-like family includes ACTL7A, ACTL7B and ACTL9 (also known as ACTL7C). In mammalian, ACTL7A is expressed in a wide variety of adult tissues, while the ACTL7B is expressed in spermatids through the elongation phase of spermatid development. ACTL7A, also called actin-like-7-alpha, or T-ACTIN-2 in mouse, may play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis. ACTL7B, also called actin-like-7-beta, acts as a key regulator of spermiogenesis that is required for male fertility. ACTL9 is a testis-specific protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation.


Pssm-ID: 466819 [Multi-domain]  Cd Length: 368  Bit Score: 307.81  E-value: 1.80e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   7 KVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRsTTKVGNIEiKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMK 86
Cdd:cd10214   4 KAVIIDLGTGYCKAGFAGQPRPSYVISSTVGKPPQE-SAKTGDNR-KETFVGKELANVEPPLKLVNPLRHGIVVDWDCVQ 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  87 HLWDYTFGPEkLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHI 166
Cdd:cd10214  82 DIWEYIFEKE-MKILPEEHAVLVSDPPLSPTTNREKYAELMFETFSIPAMHIAYQSRLSLYSYGRTSGLVVESGHGVSYV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 167 CPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSaDFETVRMIKEKLCYVGYNIEQEQKLAL-ETTVlveSYT 245
Cdd:cd10214 161 VPIHEGYNLPHITGRADYAGSDLTAYLMKLLNEAGNKFTDD-QLHIVEDIKKKCCYVALDFEEEMGLPPqEYTV---DYE 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 246 LPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERElkqly 325
Cdd:cd10214 237 LPDGHLITIGKERFRCPEMLFNPSLIGSKQPGLHTLTMNSLNKCDANLKKDLAKNILLCGGSTMFDGFPDRFQKE----- 311
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62899645 326 LERVLKGDveklskfKIRIEDPPRRKHMVFLGGAVLADiMKDKDNFWMTRQEYQEKG 382
Cdd:cd10214 312 LSKLCPND-------NPIVAASPERKYSVWTGGSILAS-LKSFQQLWVRRREYEERG 360
ASKHA_NBD_Arp3-like cd10221
nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; Arp3, ...
8-385 2.17e-97

nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; Arp3, also called actin-like protein 3, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp3 and Arp3B are encoded by the ACTR3 and ACTR3B genes respectively. Arp3B is also known as actin-related protein Arp4.


Pssm-ID: 466822  Cd Length: 404  Bit Score: 296.02  E-value: 2.17e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   8 VVVCDNGTGFVKCGYAGSNFPEHIFPALVGrpiIRSTTKVGN--------IEIKDLMVGDEASELRSMLEVNYPMENGIV 79
Cdd:cd10221   1 AVVIDNGTGYTKMGYAGNTEPQFIIPTVIA---IKESAKVGDgqrrskkgIEDLDFYIGDEALANSPTYALKYPIRHGIV 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  80 RNWDDMKHLW-----DYtfgpekLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYA------ 148
Cdd:cd10221  78 EDWDLMERFWeqcifKY------LRCEPEDHYFLLTEPPLNPPENREYTAEIMFETFNVPGLYIAVQAVLALAAswtsrk 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 149 --QGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYN 226
Cdd:cd10221 152 vgERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREEGIPPEDSLEVAKRIKERYCYVCPD 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 227 IEQE-QKLALETTVLVESYTLPDGRI-----IKVGGERFEAPEALFQPHLINVEG-VGVAELLFNTIQAADIDTRSEFYK 299
Cdd:cd10221 232 IVKEfAKYDSDPAKYIKQYTGINSVTgkpytVDVGYERFLAPEIFFNPEIASSDFtTPLPEVVDQVIQSCPIDTRRGLYK 311
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 300 HIVLSGGSTMYPGLPSRLERELKQLYLERVlkGDVEKLSKFKIR---IE----DPPRRKHMVFLGGAVLADiMKDKDNFW 372
Cdd:cd10221 312 NIVLSGGSTMFKDFGRRLQRDVKRIVDARL--KASEELSGGKLKpkpIDvnviSHPMQRYAVWFGGSMLAS-TPEFYTVC 388
                       410
                ....*....|...
gi 62899645 373 MTRQEYQEKGVRV 385
Cdd:cd10221 389 HTKAEYEEYGPSI 401
PTZ00280 PTZ00280
Actin-related protein 3; Provisional
7-382 7.34e-95

Actin-related protein 3; Provisional


Pssm-ID: 240343 [Multi-domain]  Cd Length: 414  Bit Score: 290.09  E-value: 7.34e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645    7 KVVVCDNGTGFVKCGYAGSNFPEHIFPALVG---RPIIRSTTKVgnIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWD 83
Cdd:PTZ00280   5 PVVVIDNGTGYTKMGYAGNTEPTYIIPTLIAdnsKQSRRRSKKG--FEDLDFYIGDEALAASKSYTLTYPMKHGIVEDWD 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   84 DMKHLWDYTFGpEKLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQ----------GLLT 153
Cdd:PTZ00280  83 LMEKFWEQCIF-KYLRCEPEEHYFILTEPPMNPPENREYTAEIMFETFNVKGLYIAVQAVLALRASwtskkakelgGTLT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  154 GVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQE--- 230
Cdd:PTZ00280 162 GTVIDSGDGVTHVIPVVDGYVIGSSIKHIPLAGRDITNFIQQMLRERGEPIPAEDILLLAQRIKEKYCYVAPDIAKEfek 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  231 ---------QKLALETTVLVESYTlpdgriIKVGGERFEAPEALFQPHLINVE-GVGVAELLFNTIQAADIDTRSEFYKH 300
Cdd:PTZ00280 242 ydsdpknhfKKYTAVNSVTKKPYT------VDVGYERFLGPEMFFHPEIFSSEwTTPLPEVVDDAIQSCPIDCRRPLYKN 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  301 IVLSGGSTMYPGLPSRLERELKQLYLERVLK-----GDVEKLSKFKIRIEDPPRRKHMVFLGGAVLAdIMKDKDNFWMTR 375
Cdd:PTZ00280 316 IVLSGGSTMFKGFDKRLQRDVRKRVDRRLKKaeelsGGKLKPIPIDVNVVSHPRQRYAVWYGGSMLA-SSPEFEKVCHTK 394

                 ....*..
gi 62899645  376 QEYQEKG 382
Cdd:PTZ00280 395 AEYDEYG 401
PTZ00452 PTZ00452
actin; Provisional
9-388 9.72e-93

actin; Provisional


Pssm-ID: 185631  Cd Length: 375  Bit Score: 283.18  E-value: 9.72e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645    9 VVCDNGTGFVKCGYAGSNFPEHIFPALVGRPiiRSTTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHL 88
Cdd:PTZ00452   8 VVIDNGSGYCKIGIAGDDAPTSCFPAIVGRS--KQNDGIFSTFNKEYYVGEEAQAKRGVLAIKEPIQNGIINSWDDIEII 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   89 WDYTFGPEkLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICP 168
Cdd:PTZ00452  86 WHHAFYNE-LCMSPEDQPVFMTDAPMNSKFNRERMTQIMFETFNTPCLYISNEAVLSLYTSGKTIGLVVDSGEGVTHCVP 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  169 VYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPD 248
Cdd:PTZ00452 165 VFEGHQIPQAITKINLAGRLCTDYLTQILQELGYSLTEPHQRIIVKNIKERLCYTALDPQDEKRIYKESNSQDSPYKLPD 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  249 GRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYler 328
Cdd:PTZ00452 245 GNILTIKSQKFRCSEILFQPKLIGLEVAGIHHLAYSSIKKCDLDLRQELCRNIVLSGGTTLFPGIANRLSNELTNLV--- 321
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  329 vlkgdvekLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNfWMTRQEYQEKGVRVLEK 388
Cdd:PTZ00452 322 --------PSQLKIQVAAPPDRRFSAWIGGSIQCTLSTQQPQ-WIKRQEYDEQGPSIVHR 372
ASKHA_NBD_Arp4_ACTL6-like cd13395
nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The ...
9-382 3.51e-84

nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The Arp4-like subfamily includes Arp4, also called actin-like protein 4, from fungi and plants. Saccharomyces cerevisiae Arp4 acts synergistically with Arp8 to depolymerize F-actin; it binds ATP, but unlike conventional actin, does not form filaments. It is a component of the NuA4 histone acetyltransferase complex, the chromatin-remodeling INO80 complex and the SWR1 chromatin remodeling complex. Arabidopsis thaliana Arp4 is involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure. This family also includes human homologs of yeast and plant, which are actin-like protein 6A (encoded by the ACTL6A gene; also known as ArpNbeta, 53 kDa BRG1-associated factor A/BRG1-associated factor 53A/BAF35A, and INO80 complex subunit K/INO80K) and actin-like protein 6B (encoded by the ACTL6B gene; also known as ArpNalpha, 53 kDa BRG1-associated factor B/BRG1-associated factor 53B/BAF35B). ACTL6A and ACTL6B are involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). They are components of numerous complexes with chromatin remodeling and histone acetyltransferase activity. ACTL6A is also a putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Schizosaccharomyces pombe actin-related protein 42 (Arp42) is also included in this family. It is also a component of SWI/SNF and RSC complexes.


Pssm-ID: 466846 [Multi-domain]  Cd Length: 413  Bit Score: 262.50  E-value: 3.51e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   9 VVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKV----GNIEIKDLMVGDEA-SELRSMLEVNYPMENGIVRNWD 83
Cdd:cd13395   7 LVLDIGSYSTRAGYAGEDTPKAVFPSVVGVVTDDDDAEDyvggSGEKKRKYYIGTNSiGVPRPNMEVISPLKDGLIEDWD 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  84 DMKHLWDYTFGpEKLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGV 163
Cdd:cd13395  87 AFEKLWDHALK-NRLRVDPSEHPLLLTEPSWNTRANREKLTELMFEKYNVPAFFLAKNAVLSAFANGRSTALVVDSGATS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 164 THICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFN----------------------------HSADFETVRM 215
Cdd:cd13395 166 TSVVPVHDGYVLQKAIVRSPLGGDFLTDQLLKLLESKNIEIIprymikskepveggapakytkkdlpnttSSYHRYMVRR 245
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 216 I----KEKLCYVGYNIEQEQKLALETTVlveSYTLPDGRIIKVGGERFEAPEALFQPHLINVEGV---------GVAELL 282
Cdd:cd13395 246 VlqdfKESVCQVSDSPFDESEAASIPTV---SYELPDGYNIEFGAERFKIPELLFDPSLVKGIPAppsegnellGLPQLV 322
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 283 FNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYlervlkgdvekLSKFKIRIEDPP---RRKHMVFLGGA 359
Cdd:cd13395 323 YTSIGSCDVDIRPELYGNVVLTGGNSLLPGFTDRLNRELSEKA-----------PGSLKLKILASGntvERRFSSWIGGS 391
                       410       420
                ....*....|....*....|....*.
gi 62899645 360 VLADImkdkDNF---WMTRQEYQEKG 382
Cdd:cd13395 392 ILASL----GSFqqmWISKQEYEEHG 413
ASKHA_NBD_Arp6 cd10210
nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, ...
8-382 9.30e-77

nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, also called actin-like protein 6, is required for formation and/or maintenance of proper nucleolar structure and function, plays a dual role in the regulation of ribosomal DNA (rDNA) transcription. In the presence of high glucose, Arp6 maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, it is required for the repression of rDNA transcription, and this function may be independent of H2A.Z. Arp6 is also required for telomere silencing in both fission and budding yeast. It is a component of the budding yeast and Arabidopsis SWR1 complex (SWR1C) and the human SWI2/SNF2-related CBP activator protein (SRCAP) chromatin remodeling complexes which catalyze the exchange of the histone H2A with the H2AZ. Drosophila Arp6 colocalizes with HP1 (heterochromatin protein 1) in the pericentric heterochromatin, and vertebrate Arp6 also interacts with HP1. Human Arp6 is encoded by the ACTR6 gene. Arabidopsis thaliana ACTIN RELATED PROTEIN 6/EARLY IN SHORT DAYS 1/SUPPRESSOR OF FRIGIDA 3 (encoded by ARP6/ESD1/SUF3) participates in regulating several leaf and flower development stages. It is needed for Flowering locus C (FLC, the master repressor of flowering) and FLC-like gene expression in the shoot and root apex, and for the activity of the floral repressor pathway.


Pssm-ID: 466816 [Multi-domain]  Cd Length: 389  Bit Score: 242.46  E-value: 9.30e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   8 VVVCDNGTGFVKCGYAGSNFPeHIFPALVGRPiiRSTTKV-----GNIEIKDLmvgdeaSELRSMLevnyPMENGIVRNW 82
Cdd:cd10210   1 TLVLDNGAYTIKAGFASDDPP-RVIPNCIAKP--KSERRRlfgddQLDECKDL------SGLFYRR----PFERGYLVNW 67
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  83 DDMKHLWDYTFGPEKLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTG-------- 154
Cdd:cd10210  68 DLQRQIWDHLFGKLLLNVDPSDTALVLTEPPFNPPSIQEAMDEIVFEEYGFQSLYRTTAAALSAFAYLADSEqssssssq 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 155 --VVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYafNHSADFETVRMIKEKLCYVGYNIEQEQK 232
Cdd:cd10210 148 ccLVVDSGFSFTHIVPFFDGKPVKRAVRRIDVGGKLLTNYLKEIISYRQL--NVMDETYLVNQIKEDLCFVSTDFYEDLE 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 233 LA----LETTVLVEsYTLPDG-----------------------RIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNT 285
Cdd:cd10210 226 IAkkkgKENTIRRD-YVLPDYttskrgyvrdpeepnrgklkedeQVLRLNNERFTVPELLFHPSDIGIQQAGIAEAIVQS 304
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 286 IQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLylervlkgdveKLSKFKIRIEDPPRRKHMVFLGGAVLAdIM 365
Cdd:cd10210 305 INACPEELQPLLYANIVLTGGNALFPGFRERLEAELRSL-----------APDDYDVNVTLPEDPITYAWEGGSLLA-QS 372
                       410
                ....*....|....*..
gi 62899645 366 KDKDNFWMTRQEYQEKG 382
Cdd:cd10210 373 PEFEELAVTRAEYEEHG 389
COG5277 COG5277
Actin-related protein [Cytoskeleton];
1-380 3.88e-63

Actin-related protein [Cytoskeleton];


Pssm-ID: 444088  Cd Length: 424  Bit Score: 208.49  E-value: 3.88e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   1 MDSQGRK--VVVCDNGTGFVKCG-YAGSNFPEHI-----FPALVGRPIIRsttkvGNIEI--KDLMVGDEASELRSMLE- 69
Cdd:COG5277   1 MSDAYKLkyVIGIDFGTSYVKYGpIALEEKPRVIqtrglFLRIVGESKLL-----GPMEGlsRGLVVGDEVSKYLSSVRd 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  70 ----VNYPMENGIVR-----NWDDMKHLWDYTFGPEKL-NIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSG---V 136
Cdd:COG5277  76 airnLKYPLRDGIVRrddedAWRVLKELLRYTFAQFLVvDPEFHGFLVVVALSALAPDYMRERLFDIHFEVFSEEGapaV 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 137 YVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGfSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADfETVRMI 216
Cdd:COG5277 156 TIIPQPLAVAIAEKAVTCVVVEAGHGNSQVAPISRG-PIREGLVALNRGGAEANAITREILKDRGYSDTAREE-YVVRVV 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 217 KEKLCYVGYNIEQE-QKLALETTVLVESYTLPDGRIIKVGGE----RFEAPEALFQPHLINVEG---------------- 275
Cdd:COG5277 234 KEALGLVPRDLAKAiQKAASNPDSFEAKVRLPNPTVEIELGNyaweRFLIGEILFNPNHEGFESyiqqgrlriedavigd 313
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 276 ------VGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMY---PGL-------PSRLERELKQLYLErvlkgdveklsk 339
Cdd:COG5277 314 vvlygeMGLAEAIINSIMKCDVEIQDELYSNIILSGGAFNWsvpPGLedvavdsVTRVQIELSELAPE------------ 381
                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 62899645 340 FKIRIEDPPRRKHMVFLGGAVLADIMKDKDNF-WMTRQEYQE 380
Cdd:COG5277 382 LKVNVRLVSDPQYSVWKGAIIYGYALPFSVKWsWITKEGWYF 423
ASKHA_NBD_AtARP7-like cd10209
nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar ...
9-382 9.51e-59

nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar proteins; Arabidopsis thaliana ARP7 is an essential nuclear protein, ubiquitously expressed in all cell types. It is needed for normal embryogenesis, plant architecture, and floral organ abscission. It may play a role in regulating various phases of plant development through chromatin-mediated gene regulation.


Pssm-ID: 466815 [Multi-domain]  Cd Length: 354  Bit Score: 194.92  E-value: 9.51e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   9 VVCDNGTGFVKCGYAGS-NFPEHIFPALVgrpiirstTKVGNieikdlmvGDEASELRSMLEVNYPMENGIVRNWDDMKH 87
Cdd:cd10209   1 VVIDAGSRLLKAGYAYPdREPSVVEPTRV--------TPAVE--------DGEESDTVVEGNTVSPIRRGRIEDWDALEA 64
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  88 LWDYTF----GPEKLNidtrSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGV 163
Cdd:cd10209  65 LLRYVFytglGWEEGN----EGQVLIAEPLLTSKAERERLTQLMFETFNVSGLYASEQAVLSLYAVGRISGCVVDVGHGK 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 164 THICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADfeTVRMIKEKlcyVGYNIEQEQK-LALETTVLVE 242
Cdd:cd10209 141 IDIAPVWEGAIQHNAVRRFEIGGRDLTELLAAELGKSNPKVKLDRS--IVERLKEA---VAWSADDEEAyEKKVLTCSPE 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 243 SYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELK 322
Cdd:cd10209 216 TYTLPDGRVISVGKERYCVGEALFRPSILGIEEYGIVEQLVRAVSTSPSENRRQLLENIVLCGGTSSVPGLEARLQKEIR 295
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62899645 323 QLY---LERVLKGDVEKLSKFKIRiedpprrkHMVFLGGAVLADIMKDKDNFwMTRQEYQEKG 382
Cdd:cd10209 296 LLSspsSRPALVKPPEYMPENTLR--------YSAWIGGAILAKVVFPQNQH-VTKADYDETG 349
ASKHA_NBD_Arp5 cd10211
nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, ...
8-382 2.34e-58

nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, also called actin-like protein 5, may act as a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. It is involved in DNA double-strand break repair and UV-damage excision repair. Human Arp5 is encoded by the ACTR5 gene. Arabidopsis thaliana ARP5 (AtARp5) is a ubiquitously expressed nuclear protein involved in DNA repair and required for multicellular development of all organs. AtARp5 may be part of other chromatin remodeling machines in addition to INO80.


Pssm-ID: 466817 [Multi-domain]  Cd Length: 345  Bit Score: 193.56  E-value: 2.34e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   8 VVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTK----VGNiEIKDLMVGDeaSELRSmlevnyPMENGIVRNWD 83
Cdd:cd10211   1 PIVIDNGSYQCRAGWAGDKEPRLVFRNLVAKPRDRKKGItvtlVGN-DILNDEAVR--SHLRS------PFDRNVVTNFD 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  84 DMKHLWDYTFGpeKLNIDTRSCK---ILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLL----TGVV 156
Cdd:cd10211  72 LQEQILDYIFS--HLGINSEGSVdhpIVLTEALCNPNYSRQLMSELLFECYGVPSVAYGIDSLFSYYHNQPQgdpsDGLV 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 157 VDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEqklaLE 236
Cdd:cd10211 150 ISSGYSTTHVIPVLNGRLDLSQCKRINLGGFHATDYLQRLLQLKYPTHPSAITLSRAEELVHEHCYVAEDYDEE----LK 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 237 TTVLVESYTLPDgRIIKVggerfeaPealfqphlinvegVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSR 316
Cdd:cd10211 226 KWEDPEYYEENV-RKIQL-------P-------------FGLVETIEFVLKRYPAEQQDRLVQNVFLTGGNALFPGLKER 284
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62899645 317 LERELKQLYLERvlkgdveklSKFKIRIEDPPRrkHMVFLGGAVLADIMKDKdNFWMTRQEYQEKG 382
Cdd:cd10211 285 LEKELRAIRPFG---------SPFNVVRAKDPV--LDAWRGAAKWALDSTFE-KVWITKQEYEEKG 338
ASKHA_NBD_ScArp9-like cd10208
nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and ...
63-382 1.38e-43

nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and similar proteins; Saccharomyces cerevisiae Arp9, also called actin-like protein 9, chromatin structure-remodeling complex protein ARP9, or SWI/SNF complex component ARP9, is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. It is also part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. Arp9 forms a stable heterodimer with Arp7 protein in both the RSC and SWI/SNF chromatin-remodeling complexes. It has been suggested that this dimer functions as a module with DNA bending proteins, to achieve correct architecture and facilitate complex-complex interactions. Fission yeast SWI/SNF and RSC complexes do not contain Arp7 and Arp8, but instead contain Arp9 and Arp42.


Pssm-ID: 466814  Cd Length: 356  Bit Score: 155.16  E-value: 1.38e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  63 ELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPE-KLNIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQ 141
Cdd:cd10208  28 EIPTRVEIIWPIQDGRVVDWDALEALWRHILFSLlSIPRPTNNSPVLLSVPPSWSKSDLELLTQLFFERLNVPAFAILEA 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 142 AVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLL------LLRGYAFNHSADFETVRM 215
Cdd:cd10208 108 PLAALYAAGATSGIVVDIGHEKTDITPIVDSQVVPHALVSIPIGGQDCTAHLAQLLksdepeLKSQAESGEEATLDLAEA 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 216 IKE-KLCyvgynieqeqklaletTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLI-NVEGVGVAELLFNTIQAADIDT 293
Cdd:cd10208 188 LKKsPIC----------------EVLSDGADLASGTEITVGKERFRACEPLFKPSSLrVDLLIAAIAGALVLNASDEPDK 251
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 294 RSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLervlkgDVEKLS--------KFkIRIED--PPRRKHM----VFLGGA 359
Cdd:cd10208 252 RPALWENIIIVGGGSRIRGLKEALLSELQQFHL------ISETSAspqqpriiRL-AKIPDyfPEWKKSGyeeaAFLGAS 324
                       330       340
                ....*....|....*....|....*
gi 62899645 360 VLADIM--KDKDNFWMTRQEYQEKG 382
Cdd:cd10208 325 IVAKLVfnDPSSKHYISKVDYNEKG 349
ASKHA_NBD_Arp10 cd10207
nucleotide-binding domain (NBD) of actin-related protein 10 (Arp10) and similar proteins; ...
9-383 4.10e-41

nucleotide-binding domain (NBD) of actin-related protein 10 (Arp10) and similar proteins; Arp10, also known as actin-related protein 11 (Arp11), is a subunit of the cargo-binding portion of the dynein activator, dynactin. It, together with dynactin4 (p62), -5(p25), and -6(p27), forms a heterotetrameric complex located at the pointed end of Arp1. Arp1 forms a mini-filament of uniform size, with proteins bound along its length and at both ends. Human Arp10 is encoded by the ACTR10 gene.


Pssm-ID: 466813 [Multi-domain]  Cd Length: 375  Bit Score: 148.94  E-value: 4.10e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   9 VVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMvgdeasELRSML-----EVNYpmengivrnwd 83
Cdd:cd10207   1 VVLDIGSAYTKCGFAGESAPRCIIPSEVKLPGGKKVIRVVDQRSGNEE------ELYEALkeflhELYF----------- 63
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  84 dmKHLWdytfgpeklnIDTRSCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGV 163
Cdd:cd10207  64 --KHLL----------VNPKDRRVVVVESVLCPTPFRETLAKVLFKHFEVPSVLFAPSHLLSLLTLGIRTALVVDCGYRE 131
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 164 THICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSA------------DFETVRMIKEKLCYV-GYNIEQE 230
Cdd:cd10207 132 TRVLPVYEGVPLLSAWQSTPLGGKALHKRLKKLLLEHATVVTGDNkgqllssvdsllSEEVLEDIKVRACFVtSLERGKT 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 231 QKLALETTVLVES-------YTLPDGRI-IKVGGERFEAPEALFQPhliNVEGVGVAELLFNTIQAADIDTRSEFYKHIV 302
Cdd:cd10207 212 LQSATEEGSTEEPsppppvdYPLDGEKIlIVPGSIRESAEELLFEG---DNEEKSLPTLILDSLLKCPIDVRKQLAENIV 288
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 303 LSGGSTMYPGLPSRLERELKQLYLERVLKgdvEKLSKFKIRIEDPPRRKHMVF---LGGAVLAdIMKDKDNFWMTRQEYQ 379
Cdd:cd10207 289 VIGGTSMLPGFKHRLLEELRALLRKPKYF---EELAPKTFRFHTPPSVFKPNYlawLGGSIFG-ALESILGRSLSREAYL 364

                ....
gi 62899645 380 EKGV 383
Cdd:cd10207 365 QTGR 368
ASKHA_NBD_AtArp8-like cd13396
nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 8 (AtArp8) and ...
120-382 3.44e-30

nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 8 (AtArp8) and similar proteins; Arabidopsis thaliana ARP8, also called F-box protein ARP8, is an F-Box protein localized to the nucleolus. It is ubiquitously expressed in all organs and cell types and has a cell cycle-dependent subcellular pattern of distribution: it is localized to the nucleolus in interphase cells and dispersed in the cytoplasm in mitotic cells.


Pssm-ID: 466847  Cd Length: 332  Bit Score: 118.42  E-value: 3.44e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 120 REKIVEVMFETyQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTrrLDIAGR---DITRYLIKL 196
Cdd:cd13396  84 RGTIFNVLFDM-NVPAVCAVDQAVLALYAANRTSGIVVNIGFRVTTIVPVYRGRVMHDIG--VEVVGQgalRLTGFLKEL 160
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 197 LLLRGYAFNhsaDFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESytlpDGRIIkVGGERFEAPEALFQPHLINVEGV 276
Cdd:cd13396 161 MQQNGIRFP---SLYTVRTIKEKLCYVAEDYEAELAKDTQASCEVAG----EGWFT-LSNERFKTGEILFQPGLGGMRAM 232
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 277 GVAELLFNTIQAADIDTRSE---FYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGdveklskfkIRIEDPPRRKHM 353
Cdd:cd13396 233 GLHQAVALCMDHCALVHSQGddgWFKTIVLSGGSACLPGLSERLERELRKLLPKSLSEG---------IRIIPPPLGPDS 303
                       250       260
                ....*....|....*....|....*....
gi 62899645 354 VFLGGAVLADIMKDKDNFWMTRQEYQEKG 382
Cdd:cd13396 304 AWQGAKLISNLSNFPDGWCITKKQFRNKP 332
ASKHA_NBD_Arp8-like cd10206
nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The ...
53-386 3.59e-29

nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The Arp8-like family includes Arp8, also called actin-like protein 8, from vertebrates and fungi. Human Arp8 is encoded by the ACTR8 gene and is also known as INO80 complex subunit N. It plays an important role in the functional organization of mitotic chromosomes. Arp8 exhibits low basal ATPase activity, and is unable to polymerize. It is probably a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication, and probably DNA repair. it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Arp8 strongly prefers nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. This subfamily also contains Arabidopsis thaliana Arp9.


Pssm-ID: 466812 [Multi-domain]  Cd Length: 447  Bit Score: 117.73  E-value: 3.59e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  53 KDLMVGDEASELRSMLE--VNYPMENGIVrNW-----------DDMKHLWDYTFgPEKLNIDTR-----SCKILLTEppm 114
Cdd:cd10206 120 PDFLVGEEALRLPPSEEynLHWPIRRGRL-NVhsdggsltavlDDLEDIWSHAL-EEKLEIPRKdlknyRAVLVIPD--- 194
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 115 npTKNR---EKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHlTR-RLDIAGRDIT 190
Cdd:cd10206 195 --LFDRrhvKELVDLLLRRLGFSSVFVHQESVCATFGAGLSSACVVDIGAQKTSVACVEDGLSIPN-SRiRLPYGGDDIT 271
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 191 RYLIKLLLLRG--YAF---NHSADFETVRMIKEKLCyvgyNIEQeqklALETTVLVESYTLPDGRIIKVggerfeapeal 265
Cdd:cd10206 272 RCFLWLLRRSGfpYREcnlNSPLDFLLLERLKETYC----TLDQ----DDIGVQLHEFYVREPGQPTLK----------- 332
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 266 fqpHLINVegVGVAELLFNTI-QAADIDTRSEFYKHIVLSGGSTMYPGLPSRLErelkqlylERVL-KGDVEKLSKFKIR 343
Cdd:cd10206 333 ---YQFKL--LPLDEAIVQSIlSCASDELKRKMYSSILLVGGGAKIPGLAEALE--------DRLLiKIPSLFEAVETVE 399
                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 62899645 344 IEDPPRRK---HMVFLGGAVLA--DIMKDkdnFWMTRQEYQEKGVRVL 386
Cdd:cd10206 400 VLPPPKDMdpsLLAWKGGAVLAclDSAQE---LWITRKEWQRLGVRAL 444
ASKHA_NBD_MamK cd24009
nucleotide-binding domain (NBD) of the actin-like protein MamK family; MamK, also called ...
23-372 3.10e-15

nucleotide-binding domain (NBD) of the actin-like protein MamK family; MamK, also called magnetosome cytoskeleton protein MamK, is a protein with ATPase activity which forms dynamic cytoplasmic filaments (probably with paralog MamK-like) that may organize magnetosomes into long chains running parallel to the long axis of the cell. Turnover of MamK filaments is probably promoted by MamK-like (e.g.. MamJ and/or LimJ), which provides a monomer pool. MamK forms twisted filaments in the presence of ATP or GTP. It serves to close gaps between magnetosomes in the chain. Interaction with MCP10 is involved in controlling the response to magnetic fields, possibly by controlling flagellar rotation. The MamK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466859 [Multi-domain]  Cd Length: 328  Bit Score: 76.10  E-value: 3.10e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  23 AGSNFPEHIFPALVGRPIIRSTTKVGNieiKDLMVGDEASELRSMLEVNYPMENGIVRNWDD-----MKHLWDYTFGPEK 97
Cdd:cd24009  16 VTSRGKRFSFRSVVGYPKDIIARKLLG---KEVLFGDEALENRLALDLRRPLEDGVIKEGDDrdleaARELLQHLIELAL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  98 LNIDTRSCKILLTePPMNPTKNREKIVEVMFETyqFSGVYVAIQAVLTLYAQGLLTG-VVVDSGDGVTHICPVYEGFSLP 176
Cdd:cd24009  93 PGPDDEIYAVIGV-PARASAENKQALLEIAREL--VDGVMVVSEPFAVAYGLDRLDNsLIVDIGAGTTDLCRMKGTIPTE 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 177 HLTRRLDIAGRDITRYLIKLLLLRgYAfNHSADFETVRMIKEKLCYVGYNIEQeqklalettVLVEsytLP-DGRIIK-- 253
Cdd:cd24009 170 EDQITLPKAGDYIDEELVDLIKER-YP-EVQLTLNMARRWKEKYGFVGDASEP---------VKVE---LPvDGKPVTyd 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 254 VGGERFEAPEALFqPHLINvegvGVAELlfntIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLylervlkGD 333
Cdd:cd24009 236 ITEELRIACESLV-PDIVE----GIKKL----IASFDPEFQEELRNNIVLAGGGSRIRGLDTYIEKALKEY-------GG 299
                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 62899645 334 VEklskfKIRIEDPprrkhmVFLG--GAV-LADIMKDKdnFW 372
Cdd:cd24009 300 GK-----VTCVDDP------VFAGaeGALkLAQEMPEE--YW 328
ASKHA_NBD_ScArp7-like cd10212
nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein7 (Arp7) and ...
6-379 7.36e-07

nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein7 (Arp7) and similar proteins; Saccharomyces cerevisiae Arp7, also called actin-like protein 7, is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. It is also part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. Arp7 forms a stable heterodimer with Arp9 protein in both the RSC and SWI/SNF chromatin-remodeling complexes. It has been suggested that this dimer functions as a module with DNA bending proteins, to achieve correct architecture and facilitate complex-complex interactions. Fission yeast SWI/SNF and RSC complexes do not contain Arp7 and Arp8, but instead contain Arp9 and Arp42.


Pssm-ID: 466818 [Multi-domain]  Cd Length: 424  Bit Score: 50.87  E-value: 7.36e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645   6 RKVVVCDNGTGFVKCGYAGSNFPEHIFPAlvgrPIIRSTTKVGNIE--IKDLMVGDEASELRSMLEVNYPMEN-GIVRNW 82
Cdd:cd10212   3 RKCVVIHNGSHRTVAGFSNVELPQCIIPS----SYIKRTDEGGEAEfiFGTYNMIDAAAEKRNGDEVYTLVDSqGLPYNW 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645  83 DDMKHLWDYTFGPEkLNIDTRSCKILLTEPPMNPTKNR---EKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDS 159
Cdd:cd10212  79 DALEMQWRYLYDTQ-LKVSPEELPLVITMPATNGKPDMailERYYELAFDKLNVPVFQIVIEPLAIALSMGKSSAFVIDI 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 160 GDGVTHICPVYEGFSLPHLTRRLDIAGrDITRYLIKL----LLLRGYAFNHSAD-------------------------- 209
Cdd:cd10212 158 GASGCNVTPIIDGIVVKNAVVRSKFGG-DFLDFQVHErlapLIKEENDMENMADeqkrstdvwyeastwiqqfkstmlqv 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 210 -----FETVRMIKEKLCYVGYNIEQEQKL--ALETTVLVESytlPDGRIIKVGG---------------ERFEAPEALFQ 267
Cdd:cd10212 237 sekdlFELERYYKEQADIYAKQQEQLKQMdqQLQYTALTGS---PNNPLVQKKNflfkplnktltldlkECYQFAEYLFK 313
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62899645 268 PHLINVEGV---GVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERvlkgdveKLSKFKIRI 344
Cdd:cd10212 314 PQLISDKFSpedGLGPLMAKSVKKAPEQVYSLLLTNVIITGSTSLIEGMEQRIIKELSIRFPQY-------KLTTFANQV 386
                       410       420       430
                ....*....|....*....|....*....|....*
gi 62899645 345 EdpPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQ 379
Cdd:cd10212 387 M--MDRKIQGWLGALTMANLPSWSLGKWYSKEDYE 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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