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Conserved domains on  [gi|384955520|sp|Q56WD3|]
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RecName: Full=UNC93-like protein 1

Protein Classification

unc-93 family MFS transporter( domain architecture ID 12947934)

unc-93 family major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26098515|26758938|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_unc93-like cd06178
Uncharacterized Unc-93-like proteins of the Major Facilitator Superfamily of transporters; ...
 34-448 0e+00

Uncharacterized Unc-93-like proteins of the Major Facilitator Superfamily of transporters; This subfamily consists of uncharacterized proteins, mainly from fungi and plants, with similarity to Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The unc93-like subfamily belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340867  Cd Length: 415  Bit Score: 618.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  34 AQVSLMGFVCFCCPGMFNALSGMGGGGQVDPTAANNANTAVYTAFTVFGLLGGGFYNVLGPRLTLAAGCSTYVLYAGSFL 113
Cdd:cd06178    1 TQVVLVGLVCFCCPGMFNALTGLGGGGQVDPTVANNANTALYATFAVFGFFGGGIFNLLGPRLTLAFGGTGYPLYAGSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 114 YYNHHHHQAFAIVAGALLGCGAGLLWAGEGAVMTSYPPPHRKGTYIALFWSIFNLGGVIGGLIPFILNYQrSSAASVNDS 193
Cdd:cd06178   81 SYNHVQNQGFVIFAGAILGIGAGLLWTAQGAIMLSYPTENQKGRFIAIFWVIFNLGGVIGSLIPFGLNYH-STSATVNDA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 194 TYIAFMCFMFAGVLLSFGILPATSVIRNDGSRCSAVKYS-RPSTEAAAVLRLFLDRKMLLIVPAAWASNFFYSYQFNNVN 272
Cdd:cd06178  160 TYIAFIVLMAVGAVLALLLLDPPKVVRKDGGRVAAIKSAtWVSEELKLLLKLFKDPKMLLLFPAFFASNWFYTYQFNGVN 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 273 GLLFNLRTRGFNNVFYWGAQMAGSIAIGYVMDFSFKSRRARGFTGISLVAVIGTIIWAGGLANQHGYSLDKLPEKKLDFK 352
Cdd:cd06178  240 GYLFNLRTRSLNNVLYWGAQMFGAYVIGYLLDAKFMSRRTRAFIGLAIVFVIGMAIWGGGLAFQLSYTRDDVKPTPKIDD 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 353 DSGIEFAGPFVLYMSYGLLDAMYQSMVYWLIGALADDSQTLSRYSGFYKGVQSAGAAVAWQVDTRKVPLMSQLIVNWSLT 432
Cdd:cd06178  320 KTGRRYAGPFVLYLFYGILDAIYQTYVYWTMGALSNDPRKLARYAGFYKGIQSAGAAIAWRLDALKVSYMTQLIICWVLL 399

                        410
                 ....*....|....*.
gi 384955520 433 TVSYPLLVLLVYFYVK 448
Cdd:cd06178  400 AVGLPLASPVIYFYKK 415
 
Name Accession Description Interval E-value
MFS_unc93-like cd06178
Uncharacterized Unc-93-like proteins of the Major Facilitator Superfamily of transporters; ...
 34-448 0e+00

Uncharacterized Unc-93-like proteins of the Major Facilitator Superfamily of transporters; This subfamily consists of uncharacterized proteins, mainly from fungi and plants, with similarity to Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The unc93-like subfamily belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340867  Cd Length: 415  Bit Score: 618.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  34 AQVSLMGFVCFCCPGMFNALSGMGGGGQVDPTAANNANTAVYTAFTVFGLLGGGFYNVLGPRLTLAAGCSTYVLYAGSFL 113
Cdd:cd06178    1 TQVVLVGLVCFCCPGMFNALTGLGGGGQVDPTVANNANTALYATFAVFGFFGGGIFNLLGPRLTLAFGGTGYPLYAGSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 114 YYNHHHHQAFAIVAGALLGCGAGLLWAGEGAVMTSYPPPHRKGTYIALFWSIFNLGGVIGGLIPFILNYQrSSAASVNDS 193
Cdd:cd06178   81 SYNHVQNQGFVIFAGAILGIGAGLLWTAQGAIMLSYPTENQKGRFIAIFWVIFNLGGVIGSLIPFGLNYH-STSATVNDA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 194 TYIAFMCFMFAGVLLSFGILPATSVIRNDGSRCSAVKYS-RPSTEAAAVLRLFLDRKMLLIVPAAWASNFFYSYQFNNVN 272
Cdd:cd06178  160 TYIAFIVLMAVGAVLALLLLDPPKVVRKDGGRVAAIKSAtWVSEELKLLLKLFKDPKMLLLFPAFFASNWFYTYQFNGVN 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 273 GLLFNLRTRGFNNVFYWGAQMAGSIAIGYVMDFSFKSRRARGFTGISLVAVIGTIIWAGGLANQHGYSLDKLPEKKLDFK 352
Cdd:cd06178  240 GYLFNLRTRSLNNVLYWGAQMFGAYVIGYLLDAKFMSRRTRAFIGLAIVFVIGMAIWGGGLAFQLSYTRDDVKPTPKIDD 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 353 DSGIEFAGPFVLYMSYGLLDAMYQSMVYWLIGALADDSQTLSRYSGFYKGVQSAGAAVAWQVDTRKVPLMSQLIVNWSLT 432
Cdd:cd06178  320 KTGRRYAGPFVLYLFYGILDAIYQTYVYWTMGALSNDPRKLARYAGFYKGIQSAGAAIAWRLDALKVSYMTQLIICWVLL 399

                        410
                 ....*....|....*.
gi 384955520 433 TVSYPLLVLLVYFYVK 448
Cdd:cd06178  400 AVGLPLASPVIYFYKK 415
UNC-93 pfam05978
Ion channel regulatory protein UNC-93; The proteins in this family are represented by UNC-93 ...
 58-265 1.20e-12

Ion channel regulatory protein UNC-93; The proteins in this family are represented by UNC-93 from Caenorhabditis elegans and also includes protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain- containing protein 11 or protein ET). UNC-93 colocalizes with SUP-10 and SUP-9 within muscle cells. UNC-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons.


Pssm-ID: 461792 [Multi-domain]  Cd Length: 379  Bit Score: 69.27  E-value: 1.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520   58 GGGQVDPTAANNANTAVYTAFTVFGLLGGGFYNVLGPRLTLAAGCSTYVLYAGSFLYYNhhhhQAFAIVAGALLGCGAGL 137
Cdd:pfam05978   1 SPGGISAYAGYYSLAIIYFFFTFACLIAPSIVDKLTPKWSMVIGAACYAIFQLGFLFLN----SYYLYFSSALLGFGAAF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  138 LWAGEGAVMTSYPPPHRKGTYIALFWSIFNLGGVIGGLIPFILNYQRSSAASVNDST----YIAFMCFMFAGVLLsFGIL 213
Cdd:pfam05978  77 LWTGQGSYLSENSTRETIERNTSISWAMLQSSLIGGGIFLFIVFQSGGQGDEISDGQikllYSVFTAISIVGIVV-FAFL 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 384955520  214 PATSVIRNDGSRCSAVKYSRpstEAAAVLRLFLDRKMLLIVPAawasnFFYS 265
Cdd:pfam05978 156 PSPDYENVLSSKEKIQSFAD---QFKSTFRLLRTPKMLLLAVF-----FFYT 199
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
61-334 2.01e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 49.85  E-value: 2.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  61 QVDPTAANNANTAVYTAFTVFGLLGGGFYNVLGPRLTLAAGCSTYVLYAGSFLYYNHHhhqAFAIVAGALLGCGAGLLWA 140
Cdd:COG0738   39 GLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY---PLLLLALFLLGLGLGLLDV 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 141 GEGAVMTSYPPpHRKGTYIALFWSIFNLGGVIGGLIPFILNYQRSSAASVNDSTYIAFMCFMFAgVLLSFGILPATsvir 220
Cdd:COG0738  116 AANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLA-LLFLRSKLPEI---- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 221 ndgsrcsAVKYSRPSTEAAAVLRLFLDRKMLLIVPAAW--------ASNFFYSYqfnNVNGLLFNLRTRGFNNVFYWGAQ 292
Cdd:COG0738  190 -------EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFlyvgaegaIGDWLPLY---LKDVLGLSEATAALGLSLFWGGM 259

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 384955520 293 MAGSIAIGYVMDFsFKSRRA-RGFTGISLVAVIGTIIWAGGLA 334
Cdd:COG0738  260 TIGRFLGGFLLKR-FGPVRLlRLSALLAAVGLLLALLAPGPWL 301
 
Name Accession Description Interval E-value
MFS_unc93-like cd06178
Uncharacterized Unc-93-like proteins of the Major Facilitator Superfamily of transporters; ...
 34-448 0e+00

Uncharacterized Unc-93-like proteins of the Major Facilitator Superfamily of transporters; This subfamily consists of uncharacterized proteins, mainly from fungi and plants, with similarity to Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The unc93-like subfamily belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340867  Cd Length: 415  Bit Score: 618.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  34 AQVSLMGFVCFCCPGMFNALSGMGGGGQVDPTAANNANTAVYTAFTVFGLLGGGFYNVLGPRLTLAAGCSTYVLYAGSFL 113
Cdd:cd06178    1 TQVVLVGLVCFCCPGMFNALTGLGGGGQVDPTVANNANTALYATFAVFGFFGGGIFNLLGPRLTLAFGGTGYPLYAGSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 114 YYNHHHHQAFAIVAGALLGCGAGLLWAGEGAVMTSYPPPHRKGTYIALFWSIFNLGGVIGGLIPFILNYQrSSAASVNDS 193
Cdd:cd06178   81 SYNHVQNQGFVIFAGAILGIGAGLLWTAQGAIMLSYPTENQKGRFIAIFWVIFNLGGVIGSLIPFGLNYH-STSATVNDA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 194 TYIAFMCFMFAGVLLSFGILPATSVIRNDGSRCSAVKYS-RPSTEAAAVLRLFLDRKMLLIVPAAWASNFFYSYQFNNVN 272
Cdd:cd06178  160 TYIAFIVLMAVGAVLALLLLDPPKVVRKDGGRVAAIKSAtWVSEELKLLLKLFKDPKMLLLFPAFFASNWFYTYQFNGVN 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 273 GLLFNLRTRGFNNVFYWGAQMAGSIAIGYVMDFSFKSRRARGFTGISLVAVIGTIIWAGGLANQHGYSLDKLPEKKLDFK 352
Cdd:cd06178  240 GYLFNLRTRSLNNVLYWGAQMFGAYVIGYLLDAKFMSRRTRAFIGLAIVFVIGMAIWGGGLAFQLSYTRDDVKPTPKIDD 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 353 DSGIEFAGPFVLYMSYGLLDAMYQSMVYWLIGALADDSQTLSRYSGFYKGVQSAGAAVAWQVDTRKVPLMSQLIVNWSLT 432
Cdd:cd06178  320 KTGRRYAGPFVLYLFYGILDAIYQTYVYWTMGALSNDPRKLARYAGFYKGIQSAGAAIAWRLDALKVSYMTQLIICWVLL 399

                        410
                 ....*....|....*.
gi 384955520 433 TVSYPLLVLLVYFYVK 448
Cdd:cd06178  400 AVGLPLASPVIYFYKK 415
MFS_unc93_like cd17338
Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is ...
 38-431 7.47e-44

Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is composed of Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93) and similar proteins including three vertebrate members: protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. The unc93-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340896 [Multi-domain]  Cd Length: 388  Bit Score: 158.28  E-value: 7.47e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  38 LMGFVCFCCPGMFNALSGMGGGGQVDPTAaNNANTAVYTAFTVFGLLGGGFYNVLGPRLTLAAGCSTYVLYAGSFLYYNh 117
Cdd:cd17338    3 ILSFGFLLIFLAYSALQNLQTSLHENGLG-SISLGILYSSFAVSSFIAPLLVKLLGEKITLVLGGLGYAIFIASNIFPI- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 118 hhhQAFAIVAGALLGCGAGLLWAGEGAVMTSYPPPHRKGTYIALFWSIFNLGGVIGGLIPFILnYQRSSAASVNDSTYIA 197
Cdd:cd17338   81 ---WGTLVPASIILGFAAAILWTAQGTYITRISDESNIGRNFGIFWSIFQLSQVFGNLISLAL-LNHSKGSSGTTILFIV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 198 FMCFMFAGVLLSFGIL-PATSVIRNDGSRCSAVKYSRPSTeAAAVLRLFLDRKMLLIVPAAWASNFFYSYQFNNVNGLLF 276
Cdd:cd17338  157 FMAIMLVGIILLFFLRgPDNEVITEIESSSVGESMEKKNL-FKLPFTLLKDKRFLLLIPLLIYSGLEQTFFSGVFTLIIG 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 277 N----LRTRGFNNVFYWGAQMAGSIAIGYVMDfsfksrrarGFTGISLVAVIGTIIwagglanqHGYSLDKLPEKKLDFK 352
Cdd:cd17338  236 TpttgIARVGYVMAVYGFGDALGSLVAGLLSD---------WRFGRIVLAVIGAFV--------HIASLILLFLSGNVTP 298

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 384955520 353 DSGIEFAGPFVLYMSYGLLDAMYQSMVYWLIGALADDSQtlSRYSGFYKGVQSAGAAVAWQVDTRkVPLMSQLIVNWSL 431
Cdd:cd17338  299 YGLGGSWLAYVSAILWGLGDAIFNTQIYALLGSLYENDS--ESAFAVYKLWQSIATAIAYFLSPY-LPLFVKLFVLLAL 374
UNC-93 pfam05978
Ion channel regulatory protein UNC-93; The proteins in this family are represented by UNC-93 ...
 58-265 1.20e-12

Ion channel regulatory protein UNC-93; The proteins in this family are represented by UNC-93 from Caenorhabditis elegans and also includes protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain- containing protein 11 or protein ET). UNC-93 colocalizes with SUP-10 and SUP-9 within muscle cells. UNC-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons.


Pssm-ID: 461792 [Multi-domain]  Cd Length: 379  Bit Score: 69.27  E-value: 1.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520   58 GGGQVDPTAANNANTAVYTAFTVFGLLGGGFYNVLGPRLTLAAGCSTYVLYAGSFLYYNhhhhQAFAIVAGALLGCGAGL 137
Cdd:pfam05978   1 SPGGISAYAGYYSLAIIYFFFTFACLIAPSIVDKLTPKWSMVIGAACYAIFQLGFLFLN----SYYLYFSSALLGFGAAF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  138 LWAGEGAVMTSYPPPHRKGTYIALFWSIFNLGGVIGGLIPFILNYQRSSAASVNDST----YIAFMCFMFAGVLLsFGIL 213
Cdd:pfam05978  77 LWTGQGSYLSENSTRETIERNTSISWAMLQSSLIGGGIFLFIVFQSGGQGDEISDGQikllYSVFTAISIVGIVV-FAFL 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 384955520  214 PATSVIRNDGSRCSAVKYSRpstEAAAVLRLFLDRKMLLIVPAawasnFFYS 265
Cdd:pfam05978 156 PSPDYENVLSSKEKIQSFAD---QFKSTFRLLRTPKMLLLAVF-----FFYT 199
MFS_MFSD11 cd17407
UNC93-like Major facilitator superfamily domain-containing protein 11; This group is composed ...
 74-221 3.92e-07

UNC93-like Major facilitator superfamily domain-containing protein 11; This group is composed of UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET) and similar proteins, most of which are uncharacterized. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. Its expression is affected by altered energy homeostasis, suggesting plausible involvement in the energy regulation. MFSD11 belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340965  Cd Length: 387  Bit Score: 51.88  E-value: 3.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  74 VYTAFTVFGLLGGGFYNVLGPRLTLAAGCSTYVLYAGSFLyynhHHHQAFAIVAGALLGCGAGLLWAGEGAVMTSYPPPH 153
Cdd:cd17407   47 IYGVFAASNWIAPSVVAVIGPKWSMVVGGLTYSLFIASFI----QPMTWSLYTASVLLGIGAAVLWTGQGNFLTINSDSE 122

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 154 RKGTYIALFWSIFNLGGVIGGLIPFiLNYQRSSAASVNDST--YIAFMCFMFAGVLLSFGILPATSVIRN 221
Cdd:cd17407  123 TIGRNSGIFWALLQCSLLFGNLYVY-FAFQGKTTISDHDRRtvFIVLTVISLVGVVLLFLLRKPPSEPKE 191
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 36-337 1.03e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 50.50  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  36 VSLMGFVCFCCPGMFN-ALSGMGGGGQVDPTAANNANTAVYTAFTVFGLLGGGFYNVLGPRLTLAAGCstyVLYAGSFLY 114
Cdd:cd06174    1 LLLGFFLTGLARGLISpLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGL---LLFALGALL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 115 YNHHHHQAFAIVAGALLGCGAGLLWAGEGAVMTSYPPPHRKGTYIALFWSIFNLGGVIGGLIPFILNYQrssaasvndST 194
Cdd:cd06174   78 FAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASS---------LG 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 195 YIAFMCFMFAGVLLSFGILPATSVIRNDGSRCSAVKYSRPSTEAAAVLRLFLDRKMLLIVPAAWASNFFYSYQFNN---- 270
Cdd:cd06174  149 FGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTllpl 228

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 384955520 271 --VNGLLFNLRTRGFNNVFYWGAQMAGSIAIGYVMDFsFKSRRARGFTGISLVAVIGTIIWAGGLANQH 337
Cdd:cd06174  229 flLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR-LIGRKPLLLIGLLLMALGLALLLLAPSLLLL 296
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
61-334 2.01e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 49.85  E-value: 2.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  61 QVDPTAANNANTAVYTAFTVFGLLGGGFYNVLGPRLTLAAGCSTYVLYAGSFLYYNHHhhqAFAIVAGALLGCGAGLLWA 140
Cdd:COG0738   39 GLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY---PLLLLALFLLGLGLGLLDV 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 141 GEGAVMTSYPPpHRKGTYIALFWSIFNLGGVIGGLIPFILNYQRSSAASVNDSTYIAFMCFMFAgVLLSFGILPATsvir 220
Cdd:COG0738  116 AANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLA-LLFLRSKLPEI---- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 221 ndgsrcsAVKYSRPSTEAAAVLRLFLDRKMLLIVPAAW--------ASNFFYSYqfnNVNGLLFNLRTRGFNNVFYWGAQ 292
Cdd:COG0738  190 -------EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFlyvgaegaIGDWLPLY---LKDVLGLSEATAALGLSLFWGGM 259

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 384955520 293 MAGSIAIGYVMDFsFKSRRA-RGFTGISLVAVIGTIIWAGGLA 334
Cdd:COG0738  260 TIGRFLGGFLLKR-FGPVRLlRLSALLAAVGLLLALLAPGPWL 301
MFS_1 pfam07690
Major Facilitator Superfamily;
62-339 3.99e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.57  E-value: 3.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520   62 VDPTAANNANTAVYTAFTVFGLLGGGFYNVLGPRLTLAAGcstYVLYAGSFLYYNHHHHQAFAIVAGALLGCGAGLLWAG 141
Cdd:pfam07690  29 ISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIG---LLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPA 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  142 EGAVMTSYPPPHRKGTYIALFWSIFNLGGVIGGLIPFILNYQRSSAAsvndsTYIAFMCFMFAGVLLSFGILPATSVIRN 221
Cdd:pfam07690 106 ALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRA-----AFLILAILSLLAAVLLLLPRPPPESKRP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  222 DGSRcsavkysRPSTEAAAVLRLFLDRKMLLIVPAAWASNFFYSYQFNNVNGLL----FNLRTRGFNNVFYWGAQMAGSI 297
Cdd:pfam07690 181 KPAE-------EARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQevlgLSALLAGLLLGLGGLLGAIGRL 253

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 384955520  298 AIGYVMDfSFKSRRARGFTGISLVAVIGTIIWAGGLANQHGY 339
Cdd:pfam07690 254 LLGRLSD-RLGRRRRLLLALLLLILAALGLLLLSLTLSSLWL 294
MFS_1 pfam07690
Major Facilitator Superfamily;
77-173 8.48e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.80  E-value: 8.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520   77 AFTVFGLLGGGFYNVLGPRLTLAAGCSTYVLYAGSFLYYNHHHHQAFAIVAGALLGCGAGLLWAGEGAVMTSYPPPHRKG 156
Cdd:pfam07690 247 LGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERG 326

                          90
                  ....*....|....*..
gi 384955520  157 TYIALFWSIFNLGGVIG 173
Cdd:pfam07690 327 TASGLYNTAGSLGGALG 343
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
23-330 1.04e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 47.28  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  23 PENKWRFNSPLAQVSLMGFVCFCCPGMFN-ALSGMGGGGQVDPTAANNANTAVYTAFTVFGLLGGGFYNVLGPRLTLAAG 101
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLpALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 102 CSTYVLyaGSFLYYNHHHHQAFaIVAGALLGCGAGLLWAGEGAVMTSYPPPHRKGTYIALFWSIFNLGGVIGGLIPFILN 181
Cdd:COG2814   82 LLLFAL--GSLLCALAPSLWLL-LAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 182 YQRSSAAsvndsTYIAFMCFMFAGVLLSFGILPATSVirndgsrcsavkySRPSTEAAAVLRLFLDRKMLLIVPAAWASN 261
Cdd:COG2814  159 DLFGWRW-----VFLVNAVLALLALLLLLRLLPESRP-------------AARARLRGSLRELLRRPRLLLLLLLAFLLG 220

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 384955520 262 F-------FYSYQFNNVNGLlfNLRTRGFNNVFYWGAQMAGSIAIGYVMDfsfKSRRARGFTGISLVAVIGTIIWA 330
Cdd:COG2814  221 FgffalftYLPLYLQEVLGL--SASAAGLLLALFGLGGVLGALLAGRLAD---RFGRRRLLLIGLLLLALGLLLLA 291
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 80-206 1.87e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 46.84  E-value: 1.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  80 VFGLLGGGFYNVLGPRLTLAAGCstyVLYAGSFLYYNHHHHQAFAIVAGALLGCGAGLLW-AGEGAVMTSYPPPHRKGTY 158
Cdd:cd17329   50 VASLIGGRLADRFGRKPVMLAGL---LLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEpASEAMIADVTTPENRTRAF 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 384955520 159 IALFWSIfNLGGVIGGLI-PFILNYQRSSAASVNDSTYIAFMCFMFAGV 206
Cdd:cd17329  127 SLLYWAI-NLGVAIGPLLgGLLLLYSFRLLFLAAAVLFLLAALVLLFLL 174
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 3-213 2.28e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 46.42  E-value: 2.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520   3 VRDEGKTTAEKHGGGEENKSPENKWRFNSPLAQVSLMGFVCFCCPGMFNA-----LSGMGGggqVDPTAANNANTAVYTA 77
Cdd:cd17325  171 LPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPflplyAAELGG---LSPAQIGLLFGAQGLA 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  78 FTVFGLLGGGFYNVLGPRLTLAAGCstyVLYAGSFLYYNHHHHQAFAIVAGALLGCGAGLLWAGEGAVMTSYPPPHRKGT 157
Cdd:cd17325  248 SALSQPPAGKLSDRIGRKPLILIGL---LLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGT 324

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 384955520 158 YIALFWSIFNLGGVIGGLIpfilnyqrssAASVNDSTYIAFMCFMFAGVLLSFGIL 213
Cdd:cd17325  325 AMGLFNTAFSLGMVLGPLL----------GGFLYDAFGFATPFLAAAALLLLAAVL 370
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 58-215 1.04e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 44.47  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  58 GGGQVDPTAANNANTAVYTAFTVFGLLGGGFYNVLGPRLTLAAGCSTYVLYAGSFLYYNHHHHQAFAIVAGALLGCGAGL 137
Cdd:cd17321  197 GVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGL 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 138 LWAGEGAVMTSYPPPHRKGTYIALFWSIFNLGGVIG----------GLIPFILNYQRSSAASVNDSTYIAFM--CFMFAG 205
Cdd:cd17321  277 FATPLTNAALSSVPKEKAGAASGILNTARQLGGALGvallgalltaGLSANLGDSGVAALLSAAAAAFAAGFhlAFLVAA 356

                        170
                 ....*....|
gi 384955520 206 VLLSFGILPA 215
Cdd:cd17321  357 ALALLAALLA 366
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
33-216 1.84e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 43.71  E-value: 1.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  33 LAQVSLMGFVCFCCPGMFNALSG-----MGGGGQVDPTAANNANTAVYTAFTVFGLLGGGFYNVLGPRLTLAAGCStYVL 107
Cdd:COG2271  179 LLRFWLLALAYFLVYFALYGFLTwlptyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIG-LLL 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 108 YAGSFLYYNHHHHQAFAIVAGALLGCGAGLLWAGEGAVMTSYPPPHRKGTYIALFWSIFNLGGVIGG-LIPFILNYQRSS 186
Cdd:COG2271  258 AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPlLVGYLLDATGYQ 337

                        170       180       190
                 ....*....|....*....|....*....|
gi 384955520 187 AAsvndstYIAFMCFMFAGVLLSFGILPAT 216
Cdd:COG2271  338 AA------FLLLAALALLAALLALLLLRET 361
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
61-176 3.49e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.55  E-value: 3.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  61 QVDPTAANNANTAVYTAFTVFGLLGGGFYNVLGPRLTLAAGCstyVLYAGSFLYYNHHHHQAFAIVAGALLGCGAGLLWA 140
Cdd:COG2271   41 GLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL---LLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFP 117

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 384955520 141 GEGAVMTSYPPPHRKGTYIALFWSIFNLGGVIGGLI 176
Cdd:COG2271  118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPL 153
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 72-176 7.26e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 41.76  E-value: 7.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  72 TAVYTAF----TVFGLLGGGFYNVLGPRLTLAAGcstYVLYAGSFLYYNHHHHQAFAIVAGALLGCGAGLLWAGEGAVMT 147
Cdd:cd17370  237 PLLYALFnlvyALAAYPAGRLSDRIGRKKLLILG---YLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVA 313

                         90       100
                 ....*....|....*....|....*....
gi 384955520 148 SYPPPHRKGTYIALFWSIFNLGGVIGGLI 176
Cdd:cd17370  314 DLVPAELRGTAYGLFNTVVGIGWLLASLI 342
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
33-176 8.18e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 41.40  E-value: 8.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  33 LAQVSLMGFVCFCCPGMFNALSG-MGGGGQVDPTAANNANTAVYTAFTVFGLLGGGFYNVLGPRLTLAAGCSTYVLyaGS 111
Cdd:COG2223    7 LLLATLAFFLAFGVWYLWSVLAPpLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI--GL 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 384955520 112 FLYYNHHHHQAFaIVAGALLGCGAGLLWAGEGAVMTSYPPPHRKGTYIALFWSIFNLGGVIGGLI 176
Cdd:COG2223   85 LLLALAVSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFL 148
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 62-208 3.25e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 39.51  E-value: 3.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  62 VDPTAANNANTAVYTAFTVFGLLGGGFYNVLGPRLTLAAGCSTYVLyAGSFLYYNHHHHQAFAIVAGALLGCGAGLLWAG 141
Cdd:cd17316  210 LSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI-LALPLFYLLSGSPTLLLLLLFILSFFVGGVWGA 288

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 384955520 142 EGAVMTSYPPPHRKGTYIALFWsifNLGGVIGGLIPFILNYQRSSAASVNDSTYIAFMCFMFAGVLL 208
Cdd:cd17316  289 LYAYLAELFPTEVRATGVGLSY---NLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVA 352
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 77-220 4.71e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 39.10  E-value: 4.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  77 AFTVFGLLGGGFYNVLGPRLTLAAGcsTYVLYAGSFLYYNHHHHQAFAIVAGALLGCGAGLLWAGEGAVMTSYPPPHRKG 156
Cdd:cd17504  229 VMLIAGPLAGRLIARVGPRRVLLIG--LVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTG 306

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 384955520 157 TYIALFWSIFNLGGVIGGLI-PFILNYQRSSAASVNDSTYIAFMCFMFAGVLLSFGILPATSVIR 220
Cdd:cd17504  307 IATGMNTVLRTIGSAIGPAIaGAILTTYTVSITSGGVPTEGAYVLAFLIGAALALAALLLSLLIP 371
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 73-265 6.02e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 38.71  E-value: 6.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  73 AVYTAFTVFGLLGGGFY-NVLGPRLTLAAGcstYVLYAGSFLYYNHHHHQAFAIVAGALLGCGAGLLWAGEGAVMTSYPP 151
Cdd:cd17325   38 AAYALAQLLFSPPAGRLsDRFGRKRLLLLG---LLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAP 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520 152 PHRKGTYIALFWSIFNLGGVIGGLIPFILnYQRSSAASVndstYIAFMCFMFAGVLLSFGILPATSVIRNDGSRcsavky 231
Cdd:cd17325  115 PEERGRAMGIFSSAIGLGFLIGPLLGGLL-ADALGYRAP----FLVCAALALLALVLALLLLPEPRPPPNKRAV------ 183

                        170       180       190
                 ....*....|....*....|....*....|....
gi 384955520 232 sRPSTEAAAVLRLFLDRKMLLIVPAAWASNFFYS 265
Cdd:cd17325  184 -SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFG 216
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 77-176 6.89e-03

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 38.31  E-value: 6.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384955520  77 AFTVFGLLGGGFYNVLGPRLTLAAGCSTYVLyaGSFLyynhhhhQAFA------IVAGALLGCGAGLLWAGEGAVMTSYP 150
Cdd:cd17502   42 TSTAFQPIYGKLSDLFGRKWVLLIAIVIFEL--GSLL-------CGLApnmtmlIVGRAIQGIGGGGLMSLAFIIIADLV 112

                         90       100
                 ....*....|....*....|....*.
gi 384955520 151 PPHRKGTYIALFWSIFNLGGVIGGLI 176
Cdd:cd17502  113 PPRERGKYQGYIGAVFGIASVAGPLI 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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