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Conserved domains on  [gi|88911357|sp|Q498T9|]
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RecName: Full=Volume-regulated anion channel subunit LRRC8C; AltName: Full=Leucine-rich repeat-containing protein 8C

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-338 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 593.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357     1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSLSNVSQTvINTTP 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANS-LSPTQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357    81 LPPPKPSPTNPATVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFIS 160
Cdd:pfam12534  80 SAPTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357   161 ILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSNTIQSGPEGSLVKSQSLKSIPEKFVVD-KSTAGALDK 232
Cdd:pfam12534 160 ILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357   233 KEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTM 312
Cdd:pfam12534 240 KEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNL 319

                         330       340
                  ....*....|....*....|....*.
gi 88911357   313 AHLFSKLSFCYLCFVSIYGLTCLYTL 338
Cdd:pfam12534 320 AFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
582-772 3.51e-35

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 138.91  E-value: 3.51e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 582 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWYNSIAYIPEHIKKLTS 661
Cdd:COG4886  89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 662 LERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 741
Cdd:COG4886 161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                       170       180       190
                ....*....|....*....|....*....|.
gi 88911357 742 SVLsPKIGNLLFLSYLDIKGNHFEVLPPELG 772
Cdd:COG4886 241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
PLN03210 super family cl33662
Resistant to P. syringae 6; Provisional
 425-665 2.94e-03

Resistant to P. syringae 6; Provisional


The actual alignment was detected with superfamily member PLN03210:

Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.40  E-value: 2.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357   425 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIH-SAALSFLKEnLKVLSVKFDDM 503
Cdd:PLN03210  615 KLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVElPSSIQYLNK-LEDLDMSRCEN 693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357   504 RELPPWMYGLR---------------------NLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQA--V 560
Cdd:PLN03210  694 LEILPTGINLKslyrlnlsgcsrlksfpdistNISWLDLDETAIEEFPSNLRLENLDELILCEMKSEKLWERVQPLTplM 773

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357   561 VDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHC-DLERIPHAVfSLLSLQELDLKE-NNLKSIEEIVSfqhlrK 638
Cdd:PLN03210  774 TMLSPSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENCiNLETLPTGI-NLESLESLDLSGcSRLRTFPDIST-----N 847

                         250       260
                  ....*....|....*....|....*..
gi 88911357   639 LTVLKLWYNSIAYIPEHIKKLTSLERL 665
Cdd:PLN03210  848 ISDLNLSRTGIEEVPWWIEKFSNLSFL 874
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-338 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 593.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357     1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSLSNVSQTvINTTP 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANS-LSPTQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357    81 LPPPKPSPTNPATVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFIS 160
Cdd:pfam12534  80 SAPTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357   161 ILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSNTIQSGPEGSLVKSQSLKSIPEKFVVD-KSTAGALDK 232
Cdd:pfam12534 160 ILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357   233 KEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTM 312
Cdd:pfam12534 240 KEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNL 319

                         330       340
                  ....*....|....*....|....*.
gi 88911357   313 AHLFSKLSFCYLCFVSIYGLTCLYTL 338
Cdd:pfam12534 320 AFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
582-772 3.51e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 138.91  E-value: 3.51e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 582 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWYNSIAYIPEHIKKLTS 661
Cdd:COG4886  89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 662 LERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 741
Cdd:COG4886 161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                       170       180       190
                ....*....|....*....|....*....|.
gi 88911357 742 SVLsPKIGNLLFLSYLDIKGNHFEVLPPELG 772
Cdd:COG4886 241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 441-777 6.98e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.49  E-value: 6.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357  441 FEITELQSLK-LEIIKNVM---IPATIAQLDNLQELslhqcsvkihsaalsFLKENlkvlsvKFDDmrELPPWMYGLRNL 516
Cdd:PLN00113 230 YEIGGLTSLNhLDLVYNNLtgpIPSSLGNLKNLQYL---------------FLYQN------KLSG--PIPPSIFSLQKL 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357  517 EELYLV-GSLSHDISknvtlESLRDLKSLKILSIKSN--VSKIPQAVVDVSsHLQKMCIHNDGTKLVMLNNLKKMTNLTE 593
Cdd:PLN00113 287 ISLDLSdNSLSGEIP-----ELVIQLQNLEILHLFSNnfTGKIPVALTSLP-RLQVLQLWSNKFSGEIPKNLGKHNNLTV 360

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357  594 LELVHCDLE-RIPHAVFSLLSLQELDLKENNL-----KSIEEIVSFQHLR------------KLTVLKLWY-------NS 648
Cdd:PLN00113 361 LDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLegeipKSLGACRSLRRVRlqdnsfsgelpsEFTKLPLVYfldisnnNL 440

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357  649 IAYIPEHIKKLTSLERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNKVES-LPDELY 726
Cdd:PLN00113 441 QGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELS 520

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 88911357  727 FCKKLKTLKIGKNSLSVLSP-KIGNLLFLSYLDIKGNHFE-VLPPELGDCRAL 777
Cdd:PLN00113 521 SCKKLVSLDLSHNQLSGQIPaSFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 578-764 1.76e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.56  E-value: 1.76e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 578 KLVMLNNLKKMTNLTELELVHCDLERIPHaVFSLLSLQELDLKENNLKSIEeivSFQHLRKLTVLKLWYNSIAYIpEHIK 657
Cdd:cd21340  13 NITKIDNLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGGNRISVV-EGLE 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 658 KLTSLERLFFSHNKvevLPSHLFLCNKIRYLDlsyndirfippeiGVLQSLQYFSITCNKVESLpDELYFCKKLKTLKIG 737
Cdd:cd21340  88 NLTNLEELHIENQR---LPPGEKLTFDPRSLA-------------ALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDAS 150

                       170       180       190
                ....*....|....*....|....*....|
gi 88911357 738 KN---SLSVLSPKIGNLLFLSYLDIKGNHF 764
Cdd:cd21340 151 NNqisDLEELLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
589-649 2.13e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 2.13e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 88911357   589 TNLTELELVHCDLERIPHAVFS-LLSLQELDLKENNLKSIEEiVSFQHLRKLTVLKLWYNSI 649
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 425-665 2.94e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.40  E-value: 2.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357   425 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIH-SAALSFLKEnLKVLSVKFDDM 503
Cdd:PLN03210  615 KLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVElPSSIQYLNK-LEDLDMSRCEN 693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357   504 RELPPWMYGLR---------------------NLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQA--V 560
Cdd:PLN03210  694 LEILPTGINLKslyrlnlsgcsrlksfpdistNISWLDLDETAIEEFPSNLRLENLDELILCEMKSEKLWERVQPLTplM 773

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357   561 VDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHC-DLERIPHAVfSLLSLQELDLKE-NNLKSIEEIVSfqhlrK 638
Cdd:PLN03210  774 TMLSPSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENCiNLETLPTGI-NLESLESLDLSGcSRLRTFPDIST-----N 847

                         250       260
                  ....*....|....*....|....*..
gi 88911357   639 LTVLKLWYNSIAYIPEHIKKLTSLERL 665
Cdd:PLN03210  848 ISDLNLSRTGIEEVPWWIEKFSNLSFL 874
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 512-622 5.19e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 5.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 512 GLRNLEELYLVGSLshdISKNVTLESLRDLKSLKILS--IKSNVSKI--PQAVVDVSSHLQKMCIHNDgtKLVMLNNLKK 587
Cdd:cd21340  66 NLVNLKKLYLGGNR---ISVVEGLENLTNLEELHIENqrLPPGEKLTfdPRSLAALSNSLRVLNISGN--NIDSLEPLAP 140

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 88911357 588 MTNLTELELVHCDLERIP---HAVFSLLSLQELDLKEN 622
Cdd:cd21340 141 LRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-338 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 593.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357     1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSLSNVSQTvINTTP 80
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLESPPSTASLDDSYANS-LSPTQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357    81 LPPPKPSPTNPATVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFIS 160
Cdd:pfam12534  80 SAPTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357   161 ILGKCFDSPWTTRALSEVSGEDSEEKD--NRKNNMN-----RSNTIQSGPEGSLVKSQSLKSIPEKFVVD-KSTAGALDK 232
Cdd:pfam12534 160 ILGKCFDSPWTTRALSETSGEDSEEKKqrLEGNTVLpkvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357   233 KEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTM 312
Cdd:pfam12534 240 KEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNL 319

                         330       340
                  ....*....|....*....|....*.
gi 88911357   313 AHLFSKLSFCYLCFVSIYGLTCLYTL 338
Cdd:pfam12534 320 AFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
582-772 3.51e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 138.91  E-value: 3.51e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 582 LNNLKKMTNLTELELVHCDleriphAVFSLLSLQELDLKENNLKSIEEivSFQHLRKLTVLKLWYNSIAYIPEHIKKLTS 661
Cdd:COG4886  89 LTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 662 LERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 741
Cdd:COG4886 161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                       170       180       190
                ....*....|....*....|....*....|.
gi 88911357 742 SVLsPKIGNLLFLSYLDIKGNHFEVLPPELG 772
Cdd:COG4886 241 TDL-PELGNLTNLEELDLSNNQLTDLPPLAN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
515-779 7.60e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.82  E-value: 7.60e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 515 NLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTEL 594
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 595 ELVHCDLerIPHAVFSLLSLQELDLKENNlksieeivSFQHLRKLTVLKLWYNSIAYIPEHIKKLTSLERLFFSHNKVEV 674
Cdd:COG4886  81 LLSLLLL--GLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 675 LPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFL 754
Cdd:COG4886 151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                       250       260
                ....*....|....*....|....*
gi 88911357 755 SYLDIKGNHFEVLpPELGDCRALKR 779
Cdd:COG4886 231 ETLDLSNNQLTDL-PELGNLTNLEE 254
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
398-771 6.60e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.18  E-value: 6.60e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 398 NKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQC 477
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 478 SVKIHSAALSFLKENLKVLSVKFDDMRELppwmYGLRNLEELYLVGSLSHDISknvtlESLRDLKSLKILSIKSN-VSKI 556
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGNEEL----SNLTNLESLDLSGNQLTDLP-----EELANLTNLKELDLSNNqLTDL 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 557 PqavvdvsshlqkmcihndgtklvmlNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEivSFQHL 636
Cdd:COG4886 152 P-------------------------EPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE--PLGNL 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 637 RKLTVLKLWYNSIAYIPEHIKKLTSLERLFFSHNKVEVLPShLFLCNKIRYLDLSYNDIRFIPPEIGvLQSLQYFSITCN 716
Cdd:COG4886 205 TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNN 282

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*
gi 88911357 717 KVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDIKGNHFEVLPPEL 771
Cdd:COG4886 283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
356-758 8.26e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.85  E-value: 8.26e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 356 QETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSG 435
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 436 LPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKeNLKVLSVKFDDMRELPPWMYGLRN 515
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLT-NLKELDLSNNQLTDLPEPLGNLTN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 516 LEELYLVGSLSHDISknvtlESLRDLKSLKILSIKSN-VSKIPQAvvdvsshlqkmcihndgtklvmlnnLKKMTNLTEL 594
Cdd:COG4886 161 LKSLDLSNNQLTDLP-----EELGNLTNLKELDLSNNqITDLPEP-------------------------LGNLTNLEEL 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 595 ELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIvsfQHLRKLTVLKLWYNSIAYIPEhIKKLTSLERLFFSHNKVEV 674
Cdd:COG4886 211 DLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL---GNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTD 286

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 675 LP-SHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLF 753
Cdd:COG4886 287 LKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366


                ....*
gi 88911357 754 LSYLD 758
Cdd:COG4886 367 LTLGL 371
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 441-777 6.98e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.49  E-value: 6.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357  441 FEITELQSLK-LEIIKNVM---IPATIAQLDNLQELslhqcsvkihsaalsFLKENlkvlsvKFDDmrELPPWMYGLRNL 516
Cdd:PLN00113 230 YEIGGLTSLNhLDLVYNNLtgpIPSSLGNLKNLQYL---------------FLYQN------KLSG--PIPPSIFSLQKL 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357  517 EELYLV-GSLSHDISknvtlESLRDLKSLKILSIKSN--VSKIPQAVVDVSsHLQKMCIHNDGTKLVMLNNLKKMTNLTE 593
Cdd:PLN00113 287 ISLDLSdNSLSGEIP-----ELVIQLQNLEILHLFSNnfTGKIPVALTSLP-RLQVLQLWSNKFSGEIPKNLGKHNNLTV 360

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357  594 LELVHCDLE-RIPHAVFSLLSLQELDLKENNL-----KSIEEIVSFQHLR------------KLTVLKLWY-------NS 648
Cdd:PLN00113 361 LDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLegeipKSLGACRSLRRVRlqdnsfsgelpsEFTKLPLVYfldisnnNL 440

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357  649 IAYIPEHIKKLTSLERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNKVES-LPDELY 726
Cdd:PLN00113 441 QGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELS 520

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 88911357  727 FCKKLKTLKIGKNSLSVLSP-KIGNLLFLSYLDIKGNHFE-VLPPELGDCRAL 777
Cdd:PLN00113 521 SCKKLVSLDLSHNQLSGQIPaSFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 543-795 1.00e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 1.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357  543 SLKILSIKSNV--SKIPQAVVDVSShLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLE-RIPHAVFSLLSLQELDL 619
Cdd:PLN00113 165 SLKVLDLGGNVlvGKIPNSLTNLTS-LEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDL 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357  620 KENNLkSIEEIVSFQHLRKLTVLKLWYNSIA-YIPEHIKKLTSLERLFFSHNKVE-VLPSHLFLCNKIRYLDLSYNDIR- 696
Cdd:PLN00113 244 VYNNL-TGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTg 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357  697 FIPPEIGVLQSLQYFSITCNKVE-SLPDELYFCKKLKTLKIGKNSLSVLSPKI----GNL----LFLSYLDIKgnhfevL 767
Cdd:PLN00113 323 KIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGEIPEGlcssGNLfkliLFSNSLEGE------I 396

                        250       260
                 ....*....|....*....|....*...
gi 88911357  768 PPELGDCRALKRAGLvVEDALFETLPSD 795
Cdd:PLN00113 397 PKSLGACRSLRRVRL-QDNSFSGELPSE 423
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 578-764 1.76e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.56  E-value: 1.76e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 578 KLVMLNNLKKMTNLTELELVHCDLERIPHaVFSLLSLQELDLKENNLKSIEeivSFQHLRKLTVLKLWYNSIAYIpEHIK 657
Cdd:cd21340  13 NITKIDNLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGGNRISVV-EGLE 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 658 KLTSLERLFFSHNKvevLPSHLFLCNKIRYLDlsyndirfippeiGVLQSLQYFSITCNKVESLpDELYFCKKLKTLKIG 737
Cdd:cd21340  88 NLTNLEELHIENQR---LPPGEKLTFDPRSLA-------------ALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDAS 150

                       170       180       190
                ....*....|....*....|....*....|
gi 88911357 738 KN---SLSVLSPKIGNLLFLSYLDIKGNHF 764
Cdd:cd21340 151 NNqisDLEELLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
589-649 2.13e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 2.13e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 88911357   589 TNLTELELVHCDLERIPHAVFS-LLSLQELDLKENNLKSIEEiVSFQHLRKLTVLKLWYNSI 649
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
581-801 4.58e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 4.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357  581 MLNNLKKmtNLTELELVHCDLERIPHAVFSllSLQELDLKENNLKSIeeivsfqhlrkltvlklwynsiayiPEHIKklT 660
Cdd:PRK15370 172 MRDCLKN--NKTELRLKILGLTTIPACIPE--QITTLILDNNELKSL-------------------------PENLQ--G 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357  661 SLERLFFSHNKVEVLPSHLflCNKIRYLDLSYNDIRFIPPEIGvlQSLQYFSITCNKVESLPDELyfCKKLKTLKIGKNS 740
Cdd:PRK15370 221 NIKTLYANSNQLTSIPATL--PDTIQEMELSINRITELPERLP--SALQSLDLFHNKISCLPENL--PEELRYLSVYDNS 294

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 88911357  741 LSVLSPKIGNllFLSYLDIKGNHFEVLPPELgdcrALKRAGLVVEDALFETLPSDVREQMK 801
Cdd:PRK15370 295 IRTLPAHLPS--GITHLNVQSNSLTALPETL----PPGLKTLEAGENALTSLPASLPPELQ 349
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 603-778 1.03e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357  603 RIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWYNSIA-YIPEhiKKLTSLERLFFSHNKVE-VLPSHLF 680
Cdd:PLN00113  84 KISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPR--GSIPNLETLDLSNNMLSgEIPNDIG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357  681 LCNKIRYLDLSYNDIR-FIPPEIGVLQSLQYFSITCNK-VESLPDELYFCKKLKTLKIGKNSLSVLSPK-IGNLLFLSYL 757
Cdd:PLN00113 162 SFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLSGEIPYeIGGLTSLNHL 241

                        170       180
                 ....*....|....*....|..
gi 88911357  758 DIKGNHFE-VLPPELGDCRALK 778
Cdd:PLN00113 242 DLVYNNLTgPIPSSLGNLKNLQ 263
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 513-687 1.82e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 1.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 513 LRNLEELYLvgslSH-DISKnvtLESLRDLKSLKILsiksnvskipqavvdvssHLQKMCIhndgtklVMLNNLKKMTNL 591
Cdd:cd21340  45 LTNLTHLYL----QNnQIEK---IENLENLVNLKKL------------------YLGGNRI-------SVVEGLENLTNL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 592 TELelvHCDLERI---------PHAVFSLL-SLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWYNSIAYIPEHIKKLTS 661
Cdd:cd21340  93 EEL---HIENQRLppgekltfdPRSLAALSnSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSSWPS 169

                       170       180
                ....*....|....*....|....*.
gi 88911357 662 LERLFFSHNKVevlpshlflCNKIRY 687
Cdd:cd21340 170 LRELDLTGNPV---------CKKPKY 186
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 582-743 5.45e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.79  E-value: 5.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 582 LNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNL--KSIEEIVS-FQHLRKLTVLKLWYNSI-----AYIP 653
Cdd:COG5238 178 QNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIgdEGAEILAEaLKGNKSLTTLDLSNNQIgdegvIALA 257

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 654 EHIKKLTSLERLFFSHNKVEV-----LPSHLFLCNKIRYLDLSYNDIRFiPPEIGVLQSLQ-----------YFSITCNK 717
Cdd:COG5238 258 EALKNNTTVETLYLSGNQIGAegaiaLAKALQGNTTLTSLDLSVNRIGD-EGAIALAEGLQgnktlhtlnlaYNGIGAQG 336

                       170       180
                ....*....|....*....|....*.
gi 88911357 718 VESLPDELYFCKKLKTLKIGKNSLSV 743
Cdd:COG5238 337 AIALAKALQENTTLHSLDLSDNQIGD 362
LRR_8 pfam13855
Leucine rich repeat;
613-672 1.85e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.85e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 88911357   613 SLQELDLKENNLKSIEEiVSFQHLRKLTVLKLWYNSIAYI-PEHIKKLTSLERLFFSHNKV 672
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 604-670 8.69e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 8.69e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 88911357  604 IPHAVFSLLSLQELDLKENNLKSieEI-VSFQHLRKLTVLKLWYNSI-AYIPEHIKKLTSLERLFFSHN 670
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRG--NIpPSLGSITSLEVLDLSYNSFnGSIPESLGQLTSLRILNLNGN 500
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 590-695 8.99e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 8.99e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 590 NLTELELVHCDL-----ERIPHAVFSLLSLQELDLKENNLKS--IEEI-VSFQHLRKLTVLKLWYNSI-----AYIPEHI 656
Cdd:cd00116 138 ALEKLVLGRNRLegascEALAKALRANRDLKELNLANNGIGDagIRALaEGLKANCNLEVLDLNNNGLtdegaSALAETL 217

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 88911357 657 KKLTSLERLFFSHNKV------EVLPSHLFLCNKIRYLDLSYNDI 695
Cdd:cd00116 218 ASLKSLEVLNLGDNNLtdagaaALASALLSPNISLLTLSLSCNDI 262
LRR_8 pfam13855
Leucine rich repeat;
706-764 1.00e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.00e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 88911357   706 QSLQYFSITCNKVESLPDE-LYFCKKLKTLKIGKNSLSVLSPK-IGNLLFLSYLDIKGNHF 764
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 425-665 2.94e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.40  E-value: 2.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357   425 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIH-SAALSFLKEnLKVLSVKFDDM 503
Cdd:PLN03210  615 KLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVElPSSIQYLNK-LEDLDMSRCEN 693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357   504 RELPPWMYGLR---------------------NLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQA--V 560
Cdd:PLN03210  694 LEILPTGINLKslyrlnlsgcsrlksfpdistNISWLDLDETAIEEFPSNLRLENLDELILCEMKSEKLWERVQPLTplM 773

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357   561 VDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHC-DLERIPHAVfSLLSLQELDLKE-NNLKSIEEIVSfqhlrK 638
Cdd:PLN03210  774 TMLSPSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENCiNLETLPTGI-NLESLESLDLSGcSRLRTFPDIST-----N 847

                         250       260
                  ....*....|....*....|....*..
gi 88911357   639 LTVLKLWYNSIAYIPEHIKKLTSLERL 665
Cdd:PLN03210  848 ISDLNLSRTGIEEVPWWIEKFSNLSFL 874
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 512-622 5.19e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 5.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88911357 512 GLRNLEELYLVGSLshdISKNVTLESLRDLKSLKILS--IKSNVSKI--PQAVVDVSSHLQKMCIHNDgtKLVMLNNLKK 587
Cdd:cd21340  66 NLVNLKKLYLGGNR---ISVVEGLENLTNLEELHIENqrLPPGEKLTfdPRSLAALSNSLRVLNISGN--NIDSLEPLAP 140

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 88911357 588 MTNLTELELVHCDLERIP---HAVFSLLSLQELDLKEN 622
Cdd:cd21340 141 LRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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