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Conserved domains on  [gi|6920086|sp|Q46821|]
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RecName: Full=Uric acid transporter UacT

Protein Classification

nucleobase:cation symporter-2 family protein( domain architecture ID 10799042)

nucleobase:cation symporter-2 (NCS2) family protein is involved in the transport of nucleobases, such as Bacillus subtilis xanthine permease

Gene Ontology:  GO:0015205|GO:0016020|GO:0015851
PubMed:  30418564|23097742
SCOP:  3002647
TCDB:  2.A.40

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
pbuX TIGR03173
xanthine permease; All the seed members of this model are observed adjacent to genes for ...
34-443 1.17e-175

xanthine permease; All the seed members of this model are observed adjacent to genes for either xanthine phosphoribosyltransferase (for the conversion of xanthine to guanine, GenProp0696) or genes for the conversion of xanthine to urate and its concomitant catabolism (GenProp0640, GenProp0688, GenProp0686 and GenProp0687). A number of sequences scoring higher than trusted to this model are found in different genomic contexts, and the possibility exist that these transport related compounds in addition to or instead of xanthine itself. The outgroup to this family are sequences which are characterized as uracil permeases or are adjacent to established uracil phosphoribosyltransferases.


:

Pssm-ID: 274468  Cd Length: 406  Bit Score: 498.97  E-value: 1.17e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086     34 GLQHVLVMYAGAVAVPLMIGDRLGLSKEAIAMLISSDLFCCGIVTLLQCIGIGRFmGIRLPVIMSVTFAAVTPMIAIGMN 113
Cdd:TIGR03173   1 GLQHVLAMYAGAVAVPLIVGGALGLSAEQTAYLISADLFACGIATLIQTLGIGPF-GIRLPVVQGVSFAAVGPMIAIGAG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    114 PdiGLLGIFGATIAAGFITTLLAPLIGRLMPLFPPLVTGVVITSIGLSIIQVGIDWAAGGKGNPQYGNPVYLGISFAVLI 193
Cdd:TIGR03173  80 D--GLGAIFGAVIVAGLFVILLAPFFSKLVRFFPPVVTGTVITLIGLSLMPVAINWAAGGAGAPDFGSPQNLGLALLTLV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    194 FILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSGLHDASWFAIVTPMSFGMPIFDPVSILTMTAVLIIVFIESMG 273
Cdd:TIGR03173 158 IILLLNRFGKGFLRSIAVLIGLVVGTIVAAALGMVDFSGVAEAPWFALPTPFHFGAPTFDLVAILTMIIVYLVSMVETTG 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    274 MFLALGEIVGRKLSSHDIIRGLRVDGVGTMIGGTFNSFPHTSFSQNVGLVSVTRVHSRWVCISSGIILILFGMVPKMAVL 353
Cdd:TIGR03173 238 DFLALGEITGRKITEKDLAGGLRADGLGSALGGLFNTFPYTSFSQNVGLVQLTGVKSRYVVAAAGVILVLLGLFPKLAAL 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    354 VASIPQFVLGGAGLVMFGMVLATGIRILSRCNYtTNRYNLYIVAISLGVGMTPTLSHDFFSKLPAVLQPLLHSGIMLATL 433
Cdd:TIGR03173 318 VASIPQPVLGGAGLVMFGMVAASGIRILSKVDF-DRRRNLLIVAVSLGLGLGPTVVPEFFSQLPAWAQTLFSSGIAVGAI 396
                         410
                  ....*....|
gi 6920086    434 SAVVLNVFFN 443
Cdd:TIGR03173 397 SAILLNLLFN 406
 
Name Accession Description Interval E-value
pbuX TIGR03173
xanthine permease; All the seed members of this model are observed adjacent to genes for ...
34-443 1.17e-175

xanthine permease; All the seed members of this model are observed adjacent to genes for either xanthine phosphoribosyltransferase (for the conversion of xanthine to guanine, GenProp0696) or genes for the conversion of xanthine to urate and its concomitant catabolism (GenProp0640, GenProp0688, GenProp0686 and GenProp0687). A number of sequences scoring higher than trusted to this model are found in different genomic contexts, and the possibility exist that these transport related compounds in addition to or instead of xanthine itself. The outgroup to this family are sequences which are characterized as uracil permeases or are adjacent to established uracil phosphoribosyltransferases.


Pssm-ID: 274468  Cd Length: 406  Bit Score: 498.97  E-value: 1.17e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086     34 GLQHVLVMYAGAVAVPLMIGDRLGLSKEAIAMLISSDLFCCGIVTLLQCIGIGRFmGIRLPVIMSVTFAAVTPMIAIGMN 113
Cdd:TIGR03173   1 GLQHVLAMYAGAVAVPLIVGGALGLSAEQTAYLISADLFACGIATLIQTLGIGPF-GIRLPVVQGVSFAAVGPMIAIGAG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    114 PdiGLLGIFGATIAAGFITTLLAPLIGRLMPLFPPLVTGVVITSIGLSIIQVGIDWAAGGKGNPQYGNPVYLGISFAVLI 193
Cdd:TIGR03173  80 D--GLGAIFGAVIVAGLFVILLAPFFSKLVRFFPPVVTGTVITLIGLSLMPVAINWAAGGAGAPDFGSPQNLGLALLTLV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    194 FILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSGLHDASWFAIVTPMSFGMPIFDPVSILTMTAVLIIVFIESMG 273
Cdd:TIGR03173 158 IILLLNRFGKGFLRSIAVLIGLVVGTIVAAALGMVDFSGVAEAPWFALPTPFHFGAPTFDLVAILTMIIVYLVSMVETTG 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    274 MFLALGEIVGRKLSSHDIIRGLRVDGVGTMIGGTFNSFPHTSFSQNVGLVSVTRVHSRWVCISSGIILILFGMVPKMAVL 353
Cdd:TIGR03173 238 DFLALGEITGRKITEKDLAGGLRADGLGSALGGLFNTFPYTSFSQNVGLVQLTGVKSRYVVAAAGVILVLLGLFPKLAAL 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    354 VASIPQFVLGGAGLVMFGMVLATGIRILSRCNYtTNRYNLYIVAISLGVGMTPTLSHDFFSKLPAVLQPLLHSGIMLATL 433
Cdd:TIGR03173 318 VASIPQPVLGGAGLVMFGMVAASGIRILSKVDF-DRRRNLLIVAVSLGLGLGPTVVPEFFSQLPAWAQTLFSSGIAVGAI 396
                         410
                  ....*....|
gi 6920086    434 SAVVLNVFFN 443
Cdd:TIGR03173 397 SAILLNLLFN 406
UraA COG2233
Xanthine/uracil permease [Nucleotide transport and metabolism]; Xanthine/uracil permease is ...
10-444 3.27e-163

Xanthine/uracil permease [Nucleotide transport and metabolism]; Xanthine/uracil permease is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 441834  Cd Length: 439  Bit Score: 468.45  E-value: 3.27e-163
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   10 SSSGQDRPTDEVDRILSPGKLIILGLQHVLVMYAGAVAVPLMIGDRLGLSKEAIAMLISSDLFCCGIVTLLQCIGIGrfm 89
Cdd:COG2233   2 SSTASSGLVYGVDERPPLGQTLLLGLQHVLAMFGATVLVPLIVGGALGLSAAQTALLISAALFVSGIGTLLQLLGTG--- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   90 gIRLPVIMSVTFAAVTPMIAIGMNpdIGLLGIFGATIAAGFITTLLAPLIGRLMPLFPPLVTGVVITSIGLSIIQVGIDW 169
Cdd:COG2233  79 -GRLPIVLGSSFAFIAPIIAIGAA--YGLAAALGGIIVAGLVYILLGLLIKRIRRLFPPVVTGTVVMLIGLSLAPVAINM 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086  170 AAGGKGNPQYGNPVYLGISFAVLIFILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSGLHDASWFAIVTPMSFGM 249
Cdd:COG2233 156 AAGGPGAPDFGSPQNLLLALVTLAVILLLSVFGKGFLRRISILIGIVVGYIVALLLGMVDFSPVAEAPWFALPTPFPFGL 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086  250 PIFDPVSILTMTAVLIIVFIESMGMFLALGEIVGRKLSSHDIIRGLRVDGVGTMIGGTFNSFPHTSFSQNVGLVSVTRVH 329
Cdd:COG2233 236 PTFDLGAILTMLPVALVTIAETIGDILAVGEITGRDITDPRLGRGLLGDGLATMLAGLFGGFPNTTYSENIGVIALTGVY 315
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086  330 SRWVCISSGIILILFGMVPKMAVLVASIPQFVLGGAGLVMFGMVLATGIRILSRCNYTTNRyNLYIVAISLGVGMTPTLS 409
Cdd:COG2233 316 SRYVVAVAAVILILLGLFPKLGALIATIPSPVLGGATIVLFGMIAASGIRILVNVDFSNPR-NLLIVAVSLGLGLGVTGV 394
                       410       420       430
                ....*....|....*....|....*....|....*
gi 6920086  410 HDFFSKLPAVLQPLLHSGIMLATLSAVVLNVFFNG 444
Cdd:COG2233 395 PGALATLPATLGPLFLSGIALGALVAILLNLLLPG 429
Xan_ur_permease pfam00860
Permease family; This family includes permeases for diverse substrates such as xanthine, ...
28-412 2.89e-108

Permease family; This family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. However many members of this family are functionally uncharacterized and may transport other substrates. Members of this family have ten predicted transmembrane helices.


Pssm-ID: 395690 [Multi-domain]  Cd Length: 389  Bit Score: 326.56  E-value: 2.89e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086     28 GKLIILGLQHVLVMYAGAVAVPLMIGDRLGLSKEAIAMLISSDLFCCGIVTLLQCIGigrfMGIRLPVIMSVTFAAVT-P 106
Cdd:pfam00860   1 GQLLLLGLQHLLAMFAATIVVPLLVGDALGLGAEDLAQLISATFLASGIGTLLQTLI----FGIRLPIYLGSSFAFVTaL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    107 MIAIGM-NPDIGLLGIFGATIAAGFITTLLA--PLIGRLMPLFPPLVTGVVITSIGLSIIQVGIDWAAGGKGNP---QYG 180
Cdd:pfam00860  77 MIALGLaDWGIALAGLFGAVLVAGVLFTLISftGLRGRLARLFPPVVTGPVVLLIGLSLAPIAVKGAGGGWAIAdglTVG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    181 NPVYLGISFAVLIFILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSG-LHDASWFAIVTPMSFGMPIFDPVSILT 259
Cdd:pfam00860 157 LLDLLGLAVVVLAVILLLSVFLKGFFRQGPILIGIIAGWLLALFMGIVNFSPeVMDAPWFQLPHPFPFGTPLFNPGLILT 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    260 MTAVLIIVFIESMGMFLALGEIVGRKLS-SHDIIRGLRVDGVGTMIGGTFNSFPHTSFSQNVGLVSVTRVHSRWVCISSG 338
Cdd:pfam00860 237 MLAVALVAIVESTGDIRAVAKVSGRDLKpKPDLRRGLLADGLATLLSGLFGAFPTTTYAENIGVVALTKVYSRRVGVTAG 316
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6920086    339 IILILFGMVPKMAVLVASIPQFVLGGAGLVMFGMVLATGIRILSRCNYtTNRYNLYIVAISLGVGMTPTLSHDF 412
Cdd:pfam00860 317 VILILLGLIPKFAALFSSIPSPVLGGVMLVMFGMIAGSGVSNLITVDL-DSARNLLIIAVSLVLGLGISTVPEL 389
PRK10720 PRK10720
uracil transporter; Provisional
21-442 7.45e-45

uracil transporter; Provisional


Pssm-ID: 236744  Cd Length: 428  Bit Score: 162.50  E-value: 7.45e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    21 VDRILSPGKLIILGLQHVLVMYAGAVAVPLMIGdrlglSKEAIAMLISsdlfccGIVTLLQ-CIGIGRfmgirLPVIMSV 99
Cdd:PRK10720   7 VSERPPLLQTIPLSLQHLFAMFGATVLVPILFH-----INPATVLLFN------GIGTLLYlFICKGK-----IPAYLGS 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   100 TFAAVTPMIAIgmnPDIGLLGIFGATIAAGFITTLLAPLIGR-----LMPLFPPLVTGVVITSIGLSIIQVGIDWAAGGK 174
Cdd:PRK10720  71 SFAFISPVLLL---LPLGYEVALGGFIMCGVLFCLVALIVKKagtgwLDVLFPPAAMGAIVAVIGLELAGVAAGMAGLLP 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   175 GNPQYGNPVYLGISFAVLIFILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSGLHDASWFAIVTpmsFGMPIFDP 254
Cdd:PRK10720 148 AEGQTPDSKTIIISMVTLAVTVLGSVLFRGFLAIIPILIGVLVGYALSFAMGMVDTTPIIEAHWFALPT---FYTPRFEW 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   255 VSILTMTAVLIIVFIESMGMFLALGEIVGRKLSSH-DIIRGLRVDGVGTMIGGTFNSFPHTSFSQNVGLVSVTRVHSRWV 333
Cdd:PRK10720 225 FAILTILPAALVVIAEHVGHLVVTANIVKKDLLRDpGLHRSMFANGLSTVISGFFGSTPNTTYGENIGVMAITRVYSTWV 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   334 CISSGIILILFGMVPKMAVLVASIPQFVLGGAGLVMFGMVLATGIRIL--SRCNYTTNRyNLYIVAISLGVGMtptlshd 411
Cdd:PRK10720 305 IGGAAIIAILLSCVGKLAAAIQAIPLPVMGGVSLLLYGVIGASGIRVLieSKVDYNKAQ-NLILTSVILIIGV------- 376
                        410       420       430
                 ....*....|....*....|....*....|.
gi 6920086   412 ffSKLPAVLQPLLHSGIMLATLSAVVLNVFF 442
Cdd:PRK10720 377 --SGAKVNIGAAELKGMALATIVGIGLSLIF 405
NCS2_1 NF037981
purine/pyrimidine permease; Proteins of this family usually have 14 transmembrane domains. ...
29-438 6.87e-25

purine/pyrimidine permease; Proteins of this family usually have 14 transmembrane domains. They belong to the NSC2 superfamily transporters. They are specific purine and/or pyrimidine permeases.


Pssm-ID: 468300  Cd Length: 419  Bit Score: 106.60  E-value: 6.87e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    29 KLIILGLQHVLVMYAGAVAVPLMIGDRLGLSKEAIAMLISSDLFCCGIVTLLQCigigrFMGIRLPVIMSVT------FA 102
Cdd:NF037981   2 KLFLGGLQWMAFMIAASIAAPIAIADLFHLNPAETAGLVQRTIFVLGIAGLLQA-----LFGHRLPINEGPAglwwgvFT 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   103 AVTPMIAIGMNPDIGLLGIF-GATIAAG--FITTLLAPLIGRLMPLFPPLVTGVVITSIGLSIIQVGIDWAAGGKGNPQY 179
Cdd:NF037981  77 IYAGLVGTLYSTNIETLQALqGAMLVSGvfFFLLSVTGLIDKLAVLFTPVVTFIYLLLLVLQLSGSFIKGMMGIGYEGNE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   180 GNPVYLGISFAVLIFILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSGLHDASWFAIVTPMSFGMPIFDPVSILT 259
Cdd:NF037981 157 VDPLVFLLSLVVIILTFYFSRHKIKWIRQYSILLSLAGGWLLFALFGKAPAIAHTGGSIISLPELFVFGPPVFDSGLIVT 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   260 ---MTAVLIIVFIESMGMFLALGEIVGRKLSSHDIIRGLRVDGVGTMIGGTFNSFPHTSFSQNVGLVSVTRVHSRWVCIS 336
Cdd:NF037981 237 sffITLLLIANMLASIRVMEEVLKKFGKIEVSERYRQAGFASGINQLLGGLFSAIGSVPISGAAGFVATTGIPSLKPFII 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   337 SGIILILFGMVPKMAVLVASIPQFVLGGAGLVMF-GMVlatGIRILSRCNYTTNRYNLYIVAISL--GVGMTpTLSHDFF 413
Cdd:NF037981 317 GSLLVVIISLFPPLMNIFASLPAPVGYAVTFVVFsKMV---GLAFGELDKEENKERARFVIGIALlaGVGAM-FVPASAL 392
                        410       420
                 ....*....|....*....|....*
gi 6920086   414 SKLPAVLQPLLHSGIMLATLSAVVL 438
Cdd:NF037981 393 SGLPPVVASLLNNGLILGTLIAIAV 417
 
Name Accession Description Interval E-value
pbuX TIGR03173
xanthine permease; All the seed members of this model are observed adjacent to genes for ...
34-443 1.17e-175

xanthine permease; All the seed members of this model are observed adjacent to genes for either xanthine phosphoribosyltransferase (for the conversion of xanthine to guanine, GenProp0696) or genes for the conversion of xanthine to urate and its concomitant catabolism (GenProp0640, GenProp0688, GenProp0686 and GenProp0687). A number of sequences scoring higher than trusted to this model are found in different genomic contexts, and the possibility exist that these transport related compounds in addition to or instead of xanthine itself. The outgroup to this family are sequences which are characterized as uracil permeases or are adjacent to established uracil phosphoribosyltransferases.


Pssm-ID: 274468  Cd Length: 406  Bit Score: 498.97  E-value: 1.17e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086     34 GLQHVLVMYAGAVAVPLMIGDRLGLSKEAIAMLISSDLFCCGIVTLLQCIGIGRFmGIRLPVIMSVTFAAVTPMIAIGMN 113
Cdd:TIGR03173   1 GLQHVLAMYAGAVAVPLIVGGALGLSAEQTAYLISADLFACGIATLIQTLGIGPF-GIRLPVVQGVSFAAVGPMIAIGAG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    114 PdiGLLGIFGATIAAGFITTLLAPLIGRLMPLFPPLVTGVVITSIGLSIIQVGIDWAAGGKGNPQYGNPVYLGISFAVLI 193
Cdd:TIGR03173  80 D--GLGAIFGAVIVAGLFVILLAPFFSKLVRFFPPVVTGTVITLIGLSLMPVAINWAAGGAGAPDFGSPQNLGLALLTLV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    194 FILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSGLHDASWFAIVTPMSFGMPIFDPVSILTMTAVLIIVFIESMG 273
Cdd:TIGR03173 158 IILLLNRFGKGFLRSIAVLIGLVVGTIVAAALGMVDFSGVAEAPWFALPTPFHFGAPTFDLVAILTMIIVYLVSMVETTG 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    274 MFLALGEIVGRKLSSHDIIRGLRVDGVGTMIGGTFNSFPHTSFSQNVGLVSVTRVHSRWVCISSGIILILFGMVPKMAVL 353
Cdd:TIGR03173 238 DFLALGEITGRKITEKDLAGGLRADGLGSALGGLFNTFPYTSFSQNVGLVQLTGVKSRYVVAAAGVILVLLGLFPKLAAL 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    354 VASIPQFVLGGAGLVMFGMVLATGIRILSRCNYtTNRYNLYIVAISLGVGMTPTLSHDFFSKLPAVLQPLLHSGIMLATL 433
Cdd:TIGR03173 318 VASIPQPVLGGAGLVMFGMVAASGIRILSKVDF-DRRRNLLIVAVSLGLGLGPTVVPEFFSQLPAWAQTLFSSGIAVGAI 396
                         410
                  ....*....|
gi 6920086    434 SAVVLNVFFN 443
Cdd:TIGR03173 397 SAILLNLLFN 406
UraA COG2233
Xanthine/uracil permease [Nucleotide transport and metabolism]; Xanthine/uracil permease is ...
10-444 3.27e-163

Xanthine/uracil permease [Nucleotide transport and metabolism]; Xanthine/uracil permease is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 441834  Cd Length: 439  Bit Score: 468.45  E-value: 3.27e-163
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   10 SSSGQDRPTDEVDRILSPGKLIILGLQHVLVMYAGAVAVPLMIGDRLGLSKEAIAMLISSDLFCCGIVTLLQCIGIGrfm 89
Cdd:COG2233   2 SSTASSGLVYGVDERPPLGQTLLLGLQHVLAMFGATVLVPLIVGGALGLSAAQTALLISAALFVSGIGTLLQLLGTG--- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   90 gIRLPVIMSVTFAAVTPMIAIGMNpdIGLLGIFGATIAAGFITTLLAPLIGRLMPLFPPLVTGVVITSIGLSIIQVGIDW 169
Cdd:COG2233  79 -GRLPIVLGSSFAFIAPIIAIGAA--YGLAAALGGIIVAGLVYILLGLLIKRIRRLFPPVVTGTVVMLIGLSLAPVAINM 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086  170 AAGGKGNPQYGNPVYLGISFAVLIFILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSGLHDASWFAIVTPMSFGM 249
Cdd:COG2233 156 AAGGPGAPDFGSPQNLLLALVTLAVILLLSVFGKGFLRRISILIGIVVGYIVALLLGMVDFSPVAEAPWFALPTPFPFGL 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086  250 PIFDPVSILTMTAVLIIVFIESMGMFLALGEIVGRKLSSHDIIRGLRVDGVGTMIGGTFNSFPHTSFSQNVGLVSVTRVH 329
Cdd:COG2233 236 PTFDLGAILTMLPVALVTIAETIGDILAVGEITGRDITDPRLGRGLLGDGLATMLAGLFGGFPNTTYSENIGVIALTGVY 315
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086  330 SRWVCISSGIILILFGMVPKMAVLVASIPQFVLGGAGLVMFGMVLATGIRILSRCNYTTNRyNLYIVAISLGVGMTPTLS 409
Cdd:COG2233 316 SRYVVAVAAVILILLGLFPKLGALIATIPSPVLGGATIVLFGMIAASGIRILVNVDFSNPR-NLLIVAVSLGLGLGVTGV 394
                       410       420       430
                ....*....|....*....|....*....|....*
gi 6920086  410 HDFFSKLPAVLQPLLHSGIMLATLSAVVLNVFFNG 444
Cdd:COG2233 395 PGALATLPATLGPLFLSGIALGALVAILLNLLLPG 429
ncs2 TIGR00801
uracil-xanthine permease; The Nucleobase:Cation Symporter-2 (NCS2) Family (TC 2.A.40) Most of ...
28-441 2.70e-151

uracil-xanthine permease; The Nucleobase:Cation Symporter-2 (NCS2) Family (TC 2.A.40) Most of the functionally characterized members of the NCS2 family are transporters specific for nucleobases including both purines and pyrimidines. However, two closely related rat members of the family, SVCT1 and SVCT2, localized to different tissues of the body, cotransport L-ascorbate and Na+ with a high degree of specificity and high affinity for the vitamin. The NCS2 family appears to be distantly related to the NCS1 family (TC #2.A.39). [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 273276  Cd Length: 412  Bit Score: 437.11  E-value: 2.70e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086     28 GKLIILGLQHVLVMYAGAVAVPLMIGDRLGLSKEaIAMLISSDLFCCGIVTLLQCIGIGRFmgIRLPVIMSVTFAAVTPM 107
Cdd:TIGR00801   5 LQTIFLSLQHLLAMFAGAVLVPLLVGIALGLSAE-LQYLVSIALLTSGVGTLLQLFRTGGF--IGLPSVLGSSFAFIAPM 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    108 IAIGMNpdIGLLGIFGATIAAGFITTLLAPLIGRLMP----LFPPLVTGVVITSIGLSIIQVGIDWAAGGKGNPQYGNPV 183
Cdd:TIGR00801  82 IMIGSG--LGVPAIYGALIATGLLYFLVSFIIKKLGPlldrLFPPVVTGPVVMLIGLSLIPVAIDNAAGGEGAATYGSLE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    184 YLGISFAVLIFILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSGLHDASWFAIVTPMSFGmPIFDPVSILTMTAV 263
Cdd:TIGR00801 160 NLGLAFVVLALIILLNRFFKGFLKSISILIGILVGYILALAMGLVDFSPVIEAPWFSLPTPFTFP-PSFEWPAILTMLPV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    264 LIIVFIESMGMFLALGEIVGRKLS-SHDIIRGLRVDGVGTMIGGTFNSFPHTSFSQNVGLVSVTRVHSRWVCISSGIILI 342
Cdd:TIGR00801 239 AIVTLVESIGDITATADVSGRDLSgDPRLHRGVLADGLATLIGGLFGSFPNTTFAQNIGVIALTRVASRWVIVGAAVILI 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    343 LFGMVPKMAVLVASIPQFVLGGAGLVMFGMVLATGIRILSRCNYtTNRYNLYIVAISLGVGMTPTLSHDFFSKLPavlqP 422
Cdd:TIGR00801 319 ALGLVPKIAALITSIPSPVLGGAMLVMFGMVAASGIRILSRSKL-DFRRNLLIIAASVGLGLGVTGVPDIFGNLP----L 393
                         410
                  ....*....|....*....
gi 6920086    423 LLHSGIMLATLSAVVLNVF 441
Cdd:TIGR00801 394 LLLSGIALAGIVAILLNLI 412
Xan_ur_permease pfam00860
Permease family; This family includes permeases for diverse substrates such as xanthine, ...
28-412 2.89e-108

Permease family; This family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. However many members of this family are functionally uncharacterized and may transport other substrates. Members of this family have ten predicted transmembrane helices.


Pssm-ID: 395690 [Multi-domain]  Cd Length: 389  Bit Score: 326.56  E-value: 2.89e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086     28 GKLIILGLQHVLVMYAGAVAVPLMIGDRLGLSKEAIAMLISSDLFCCGIVTLLQCIGigrfMGIRLPVIMSVTFAAVT-P 106
Cdd:pfam00860   1 GQLLLLGLQHLLAMFAATIVVPLLVGDALGLGAEDLAQLISATFLASGIGTLLQTLI----FGIRLPIYLGSSFAFVTaL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    107 MIAIGM-NPDIGLLGIFGATIAAGFITTLLA--PLIGRLMPLFPPLVTGVVITSIGLSIIQVGIDWAAGGKGNP---QYG 180
Cdd:pfam00860  77 MIALGLaDWGIALAGLFGAVLVAGVLFTLISftGLRGRLARLFPPVVTGPVVLLIGLSLAPIAVKGAGGGWAIAdglTVG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    181 NPVYLGISFAVLIFILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSG-LHDASWFAIVTPMSFGMPIFDPVSILT 259
Cdd:pfam00860 157 LLDLLGLAVVVLAVILLLSVFLKGFFRQGPILIGIIAGWLLALFMGIVNFSPeVMDAPWFQLPHPFPFGTPLFNPGLILT 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    260 MTAVLIIVFIESMGMFLALGEIVGRKLS-SHDIIRGLRVDGVGTMIGGTFNSFPHTSFSQNVGLVSVTRVHSRWVCISSG 338
Cdd:pfam00860 237 MLAVALVAIVESTGDIRAVAKVSGRDLKpKPDLRRGLLADGLATLLSGLFGAFPTTTYAENIGVVALTKVYSRRVGVTAG 316
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6920086    339 IILILFGMVPKMAVLVASIPQFVLGGAGLVMFGMVLATGIRILSRCNYtTNRYNLYIVAISLGVGMTPTLSHDF 412
Cdd:pfam00860 317 VILILLGLIPKFAALFSSIPSPVLGGVMLVMFGMIAGSGVSNLITVDL-DSARNLLIIAVSLVLGLGISTVPEL 389
PRK10720 PRK10720
uracil transporter; Provisional
21-442 7.45e-45

uracil transporter; Provisional


Pssm-ID: 236744  Cd Length: 428  Bit Score: 162.50  E-value: 7.45e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    21 VDRILSPGKLIILGLQHVLVMYAGAVAVPLMIGdrlglSKEAIAMLISsdlfccGIVTLLQ-CIGIGRfmgirLPVIMSV 99
Cdd:PRK10720   7 VSERPPLLQTIPLSLQHLFAMFGATVLVPILFH-----INPATVLLFN------GIGTLLYlFICKGK-----IPAYLGS 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   100 TFAAVTPMIAIgmnPDIGLLGIFGATIAAGFITTLLAPLIGR-----LMPLFPPLVTGVVITSIGLSIIQVGIDWAAGGK 174
Cdd:PRK10720  71 SFAFISPVLLL---LPLGYEVALGGFIMCGVLFCLVALIVKKagtgwLDVLFPPAAMGAIVAVIGLELAGVAAGMAGLLP 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   175 GNPQYGNPVYLGISFAVLIFILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSGLHDASWFAIVTpmsFGMPIFDP 254
Cdd:PRK10720 148 AEGQTPDSKTIIISMVTLAVTVLGSVLFRGFLAIIPILIGVLVGYALSFAMGMVDTTPIIEAHWFALPT---FYTPRFEW 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   255 VSILTMTAVLIIVFIESMGMFLALGEIVGRKLSSH-DIIRGLRVDGVGTMIGGTFNSFPHTSFSQNVGLVSVTRVHSRWV 333
Cdd:PRK10720 225 FAILTILPAALVVIAEHVGHLVVTANIVKKDLLRDpGLHRSMFANGLSTVISGFFGSTPNTTYGENIGVMAITRVYSTWV 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   334 CISSGIILILFGMVPKMAVLVASIPQFVLGGAGLVMFGMVLATGIRIL--SRCNYTTNRyNLYIVAISLGVGMtptlshd 411
Cdd:PRK10720 305 IGGAAIIAILLSCVGKLAAAIQAIPLPVMGGVSLLLYGVIGASGIRVLieSKVDYNKAQ-NLILTSVILIIGV------- 376
                        410       420       430
                 ....*....|....*....|....*....|.
gi 6920086   412 ffSKLPAVLQPLLHSGIMLATLSAVVLNVFF 442
Cdd:PRK10720 377 --SGAKVNIGAAELKGMALATIVGIGLSLIF 405
NCS2_1 NF037981
purine/pyrimidine permease; Proteins of this family usually have 14 transmembrane domains. ...
29-438 6.87e-25

purine/pyrimidine permease; Proteins of this family usually have 14 transmembrane domains. They belong to the NSC2 superfamily transporters. They are specific purine and/or pyrimidine permeases.


Pssm-ID: 468300  Cd Length: 419  Bit Score: 106.60  E-value: 6.87e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    29 KLIILGLQHVLVMYAGAVAVPLMIGDRLGLSKEAIAMLISSDLFCCGIVTLLQCigigrFMGIRLPVIMSVT------FA 102
Cdd:NF037981   2 KLFLGGLQWMAFMIAASIAAPIAIADLFHLNPAETAGLVQRTIFVLGIAGLLQA-----LFGHRLPINEGPAglwwgvFT 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   103 AVTPMIAIGMNPDIGLLGIF-GATIAAG--FITTLLAPLIGRLMPLFPPLVTGVVITSIGLSIIQVGIDWAAGGKGNPQY 179
Cdd:NF037981  77 IYAGLVGTLYSTNIETLQALqGAMLVSGvfFFLLSVTGLIDKLAVLFTPVVTFIYLLLLVLQLSGSFIKGMMGIGYEGNE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   180 GNPVYLGISFAVLIFILLITRYAKGFMSNVAVLLGIVFGFLLSWMMNEVNLSGLHDASWFAIVTPMSFGMPIFDPVSILT 259
Cdd:NF037981 157 VDPLVFLLSLVVIILTFYFSRHKIKWIRQYSILLSLAGGWLLFALFGKAPAIAHTGGSIISLPELFVFGPPVFDSGLIVT 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   260 ---MTAVLIIVFIESMGMFLALGEIVGRKLSSHDIIRGLRVDGVGTMIGGTFNSFPHTSFSQNVGLVSVTRVHSRWVCIS 336
Cdd:NF037981 237 sffITLLLIANMLASIRVMEEVLKKFGKIEVSERYRQAGFASGINQLLGGLFSAIGSVPISGAAGFVATTGIPSLKPFII 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   337 SGIILILFGMVPKMAVLVASIPQFVLGGAGLVMF-GMVlatGIRILSRCNYTTNRYNLYIVAISL--GVGMTpTLSHDFF 413
Cdd:NF037981 317 GSLLVVIISLFPPLMNIFASLPAPVGYAVTFVVFsKMV---GLAFGELDKEENKERARFVIGIALlaGVGAM-FVPASAL 392
                        410       420
                 ....*....|....*....|....*
gi 6920086   414 SKLPAVLQPLLHSGIMLATLSAVVL 438
Cdd:NF037981 393 SGLPPVVASLLNNGLILGTLIAIAV 417
PRK11412 PRK11412
uracil/xanthine transporter;
34-438 1.11e-16

uracil/xanthine transporter;


Pssm-ID: 183124  Cd Length: 433  Bit Score: 82.13  E-value: 1.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086    34 GLQHVLVMYAGAVAVPLMIGDRLGLSKEAIAMLISSDLfccgIVTLLQCIgIGRFMGIRLPVIMSVTFAAVTPMIAIGMN 113
Cdd:PRK11412  14 GFQWFFFIFCNTVVVPPTLLSAFQLPQSSLLTLTQYAF----LATALACF-AQAFCGHRRAIMEGPGGLWWGTILTITLG 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   114 -PDIGL-LGIFGATIAAGFI-----TTLLA--PLIGRLMPLFPPLVTGVVITSIGLSIIQV---GIDWAAGGKGNPQYG- 180
Cdd:PRK11412  89 eASRGTpINDIATSLAVGIAlsgvvTILIGfsGLGHRLARLFTPMVMVVFMLLLGAQLTTIffkGMLGLPFGIADPNGKi 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   181 NPVYLGISFAVLIFILLITRYAKGFMSNVAVLLGIVFGFLLSWMM--NEVNLSGLHDASWFAIVTPMSFgmpifDPVSIL 258
Cdd:PRK11412 169 QLPPFGLSVAVMCLVLAMIIFLPQRIARYSLLVGTIVGWILWAFCfpSSHSLSGELHWQWFPLGSGGAL-----EPGIIL 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   259 TMTAVLIIVFIESMGMFLALGEIVGRKLSSHD-IIRGLRVDGVGTMIGGTFNSFPHTSFSQNVGLVSVTRVHSRWVCISS 337
Cdd:PRK11412 244 TAVITGLVNISNTYGAIRGTDVFYPQQGAGNTrYRRSFVATGFMTLITVPLAVIPFSPFVSSIGLLTQTGDYRRRSFIYG 323
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086   338 GIILILFGMVPKMAVLVASIPQFVLGGAGLVMFGMVLATGIRILSRCNYTTNryNLYIVAISLGVGMT-PTLSHDFFSKL 416
Cdd:PRK11412 324 SVMCLLVALIPALTRLFCSIPLPVSSAVMLVSYLPLLGSALVFSQQITFTAR--NIYRLALPLFVGIFlMALPPVYLQDL 401
                        410       420
                 ....*....|....*....|..
gi 6920086   417 PAVLQPLLHSGIMLATLSAVVL 438
Cdd:PRK11412 402 PLTLRPLLSNGLLVGILLAVLM 423
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
102-383 4.32e-05

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 45.87  E-value: 4.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086  102 AAVTPMIAIGMNPDIGLLGIFGATIAAGFITTLLAPL-IGRLMPLFP-PLVTGVViTSIGLSII--QV----GIDWAAGG 173
Cdd:COG0659  65 AALAVVVAAAVAPLGSLALLLAATLLAGVLQLLLGLLrLGRLARFIPrPVIVGFL-AGIAILIIlgQLphllGLPAPGGS 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086  174 K--------GNPQYGNPVYLGISFAVLIFILLITRYAKGFmsnVAVLLGIVFGFLLSWMMN-EVNLSGLHDASWFaivtp 244
Cdd:COG0659 144 FleklaallAALGEINPPTLALGLLTLAILLLLPRLLKRI---PGPLVAVVLGTLLVWLLGlDVATVGEIPSGLP----- 215
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6920086  245 mSFGMPIFDP--VSILTMTAVLI--IVFIESMGMFLALGEIVGRKLSSHdiiRGLRVDGVGTMIGGTFNSFPHT-SFSQn 319
Cdd:COG0659 216 -SFSLPDFSLetLRALLPPALTIalVGSIESLLTARAVDAMTGTRSDPN---RELIAQGLANIASGLFGGLPVTgSISR- 290
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6920086  320 vglvSVTRV----HSRWVCISSGIILILFGMVpkMAVLVASIPQFVLGgaglvmfGMVLATGIRILSR 383
Cdd:COG0659 291 ----SAVNVkagaRTRLSGIVHALFLLLVLLF--LAPLLAYIPLAALA-------AILIVVGIGLIDW 345
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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