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Conserved domains on  [gi|166899091|sp|Q42539|]
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RecName: Full=Protein-L-isoaspartate O-methyltransferase 1; Short=AtPIMT1; AltName: Full=L-isoaspartyl protein carboxyl methyltransferase; AltName: Full=Protein L-isoaspartyl methyltransferase; AltName: Full=Protein-beta-aspartate methyltransferase

Protein Classification

protein-L-isoaspartate O-methyltransferase( domain architecture ID 12014395)

protein-L-isoaspartate O-methyltransferase catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
11-220 2.16e-119

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


:

Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 338.19  E-value: 2.16e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   11 NKNKAMVENLQNHGIVTSDEVAKAMEAVDRGVFVTDR--SSAYVDSPMSIGYNVTISAPHMHAMCLQLLEkhLKPGMRVL 88
Cdd:pfam01135   1 NRNEALIENLKNYGVIKSDKVAEAMLAVDREEFVPESfkSYAYEDIPLSIGYGQTISAPHMHAMMLELLE--LKPGMRVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   89 DVGSGTGYLTACFAVMVGTEGRAIGVEHIPELVASSVKNIEASAASpflkegSLAVHVGDGRQGWAEFAPYDAIHVGAAA 168
Cdd:pfam01135  79 EIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGLE------NVIVVVGDGRQGWPEFAPYDAIHVGAAA 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 166899091  169 PEIPEALIDQLKPGGRLVIPVG-NIFQDLQVVDKNSDGSVSIKDETSVRYVPL 220
Cdd:pfam01135 153 PEIPEALIDQLKEGGRLVIPVGpNGNQVLQQFDKRNDGSVVIKDLEGVRFVPL 205
 
Name Accession Description Interval E-value
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
11-220 2.16e-119

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 338.19  E-value: 2.16e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   11 NKNKAMVENLQNHGIVTSDEVAKAMEAVDRGVFVTDR--SSAYVDSPMSIGYNVTISAPHMHAMCLQLLEkhLKPGMRVL 88
Cdd:pfam01135   1 NRNEALIENLKNYGVIKSDKVAEAMLAVDREEFVPESfkSYAYEDIPLSIGYGQTISAPHMHAMMLELLE--LKPGMRVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   89 DVGSGTGYLTACFAVMVGTEGRAIGVEHIPELVASSVKNIEASAASpflkegSLAVHVGDGRQGWAEFAPYDAIHVGAAA 168
Cdd:pfam01135  79 EIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGLE------NVIVVVGDGRQGWPEFAPYDAIHVGAAA 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 166899091  169 PEIPEALIDQLKPGGRLVIPVG-NIFQDLQVVDKNSDGSVSIKDETSVRYVPL 220
Cdd:pfam01135 153 PEIPEALIDQLKEGGRLVIPVGpNGNQVLQQFDKRNDGSVVIKDLEGVRFVPL 205
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 13-226 4.54e-79

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 236.26  E-value: 4.54e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   13 NKAMVENLQNHGIVTSDEVAKAMEAVDRGVFVTD--RSSAYVDSPMSIGYNVTISAPHMHAMCLQLLEkhLKPGMRVLDV 90
Cdd:TIGR00080   7 KKALIDKLINEGYIKSKRVIDALLSVPREEFVPEhfKEYAYVDTPLEIGYGQTISAPHMVAMMTELLE--LKPGMKVLEI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   91 GSGTGYLTACFAVMVGTEGRAIGVEHIPELVASSVKNIEAsaaspfLKEGSLAVHVGDGRQGWAEFAPYDAIHVGAAAPE 170
Cdd:TIGR00080  85 GTGSGYQAAVLAEIVGRDGLVVSIERIPELAEKAERRLRK------LGLDNVIVIVGDGTQGWEPLAPYDRIYVTAAGPK 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 166899091  171 IPEALIDQLKPGGRLVIPVGNIFQDLQVVDKNsDGSVSIKDETSVRYVPLTSREAQ 226
Cdd:TIGR00080 159 IPEALIDQLKEGGILVMPVGEYLQVLKRAEKR-GGEIIIKDVEPVAFVPLVGGEGF 213
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 10-224 6.90e-66

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 202.55  E-value: 6.90e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  10 INKNKAMVENLQNHGIVTSDEVAKAMEAVDRGVFVTD--RSSAYVDSPMSIGYNVTISAPHMHAMCLQLLEkhLKPGMRV 87
Cdd:PRK13942   3 LEEKRRVIEELIREGYIKSKKVIDALLKVPRHLFVPEylEEYAYVDTPLEIGYGQTISAIHMVAIMCELLD--LKEGMKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  88 LDVGSGTGYLTACFAVMVGTEGRAIGVEHIPELVASSVKNIEAsaaspfLKEGSLAVHVGDGRQGWAEFAPYDAIHVGAA 167
Cdd:PRK13942  81 LEIGTGSGYHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKK------LGYDNVEVIVGDGTLGYEENAPYDRIYVTAA 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 166899091 168 APEIPEALIDQLKPGGRLVIPVGNIFQDLQVVDKNSdGSVSIKDETSVRYVPLTSRE 224
Cdd:PRK13942 155 GPDIPKPLIEQLKDGGIMVIPVGSYSQELIRVEKDN-GKIIKKKLGEVAFVPLIGKN 210
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 26-221 7.04e-65

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 199.54  E-value: 7.04e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  26 VTSDEVAKAMEAVDRGVFVTD--RSSAYVDSPMSIGYNVTISAPHMHAMCLQLLEkhLKPGMRVLDVGSGTGYLTACFAV 103
Cdd:COG2518    9 VTDPRVLDAMRAVPRELFVPEalRELAYADRALPIGHGQTISQPYIVARMLEALD--LKPGDRVLEIGTGSGYQAAVLAR 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091 104 MVGtegRAIGVEHIPELVASSVKNIEAsaaspfLKEGSLAVHVGDGRQGWAEFAPYDAIHVGAAAPEIPEALIDQLKPGG 183
Cdd:COG2518   87 LAG---RVYSVERDPELAERARERLAA------LGYDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLAPGG 157

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 166899091 184 RLVIPVG-NIFQDLQVVDKNSDGsVSIKDETSVRYVPLT 221
Cdd:COG2518  158 RLVAPVGeGGVQRLVLITRTGDG-FERESLFEVRFVPLR 195
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 86-189 3.00e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 47.42  E-value: 3.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  86 RVLDVGSGTGYLTACFAVMVGteGRAIGVEHIPELVASSVKNIEAsaaspfLKEGSLAVHVGDGRQG-WAEFAPYDAI-- 162
Cdd:cd02440    1 RVLDLGCGTGALALALASGPG--ARVTGVDISPVALELARKAAAA------LLADNVEVLKGDAEELpPEADESFDVIis 72

                         90       100       110
                 ....*....|....*....|....*....|..
gi 166899091 163 -HVGAAAPEIPEALIDQ----LKPGGRLVIPV 189
Cdd:cd02440   73 dPPLHHLVEDLARFLEEarrlLKPGGVLVLTL 104
 
Name Accession Description Interval E-value
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
11-220 2.16e-119

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 338.19  E-value: 2.16e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   11 NKNKAMVENLQNHGIVTSDEVAKAMEAVDRGVFVTDR--SSAYVDSPMSIGYNVTISAPHMHAMCLQLLEkhLKPGMRVL 88
Cdd:pfam01135   1 NRNEALIENLKNYGVIKSDKVAEAMLAVDREEFVPESfkSYAYEDIPLSIGYGQTISAPHMHAMMLELLE--LKPGMRVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   89 DVGSGTGYLTACFAVMVGTEGRAIGVEHIPELVASSVKNIEASAASpflkegSLAVHVGDGRQGWAEFAPYDAIHVGAAA 168
Cdd:pfam01135  79 EIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGLE------NVIVVVGDGRQGWPEFAPYDAIHVGAAA 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 166899091  169 PEIPEALIDQLKPGGRLVIPVG-NIFQDLQVVDKNSDGSVSIKDETSVRYVPL 220
Cdd:pfam01135 153 PEIPEALIDQLKEGGRLVIPVGpNGNQVLQQFDKRNDGSVVIKDLEGVRFVPL 205
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 13-226 4.54e-79

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 236.26  E-value: 4.54e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   13 NKAMVENLQNHGIVTSDEVAKAMEAVDRGVFVTD--RSSAYVDSPMSIGYNVTISAPHMHAMCLQLLEkhLKPGMRVLDV 90
Cdd:TIGR00080   7 KKALIDKLINEGYIKSKRVIDALLSVPREEFVPEhfKEYAYVDTPLEIGYGQTISAPHMVAMMTELLE--LKPGMKVLEI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   91 GSGTGYLTACFAVMVGTEGRAIGVEHIPELVASSVKNIEAsaaspfLKEGSLAVHVGDGRQGWAEFAPYDAIHVGAAAPE 170
Cdd:TIGR00080  85 GTGSGYQAAVLAEIVGRDGLVVSIERIPELAEKAERRLRK------LGLDNVIVIVGDGTQGWEPLAPYDRIYVTAAGPK 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 166899091  171 IPEALIDQLKPGGRLVIPVGNIFQDLQVVDKNsDGSVSIKDETSVRYVPLTSREAQ 226
Cdd:TIGR00080 159 IPEALIDQLKEGGILVMPVGEYLQVLKRAEKR-GGEIIIKDVEPVAFVPLVGGEGF 213
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 10-224 6.90e-66

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 202.55  E-value: 6.90e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  10 INKNKAMVENLQNHGIVTSDEVAKAMEAVDRGVFVTD--RSSAYVDSPMSIGYNVTISAPHMHAMCLQLLEkhLKPGMRV 87
Cdd:PRK13942   3 LEEKRRVIEELIREGYIKSKKVIDALLKVPRHLFVPEylEEYAYVDTPLEIGYGQTISAIHMVAIMCELLD--LKEGMKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  88 LDVGSGTGYLTACFAVMVGTEGRAIGVEHIPELVASSVKNIEAsaaspfLKEGSLAVHVGDGRQGWAEFAPYDAIHVGAA 167
Cdd:PRK13942  81 LEIGTGSGYHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKK------LGYDNVEVIVGDGTLGYEENAPYDRIYVTAA 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 166899091 168 APEIPEALIDQLKPGGRLVIPVGNIFQDLQVVDKNSdGSVSIKDETSVRYVPLTSRE 224
Cdd:PRK13942 155 GPDIPKPLIEQLKDGGIMVIPVGSYSQELIRVEKDN-GKIIKKKLGEVAFVPLIGKN 210
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 26-221 7.04e-65

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 199.54  E-value: 7.04e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  26 VTSDEVAKAMEAVDRGVFVTD--RSSAYVDSPMSIGYNVTISAPHMHAMCLQLLEkhLKPGMRVLDVGSGTGYLTACFAV 103
Cdd:COG2518    9 VTDPRVLDAMRAVPRELFVPEalRELAYADRALPIGHGQTISQPYIVARMLEALD--LKPGDRVLEIGTGSGYQAAVLAR 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091 104 MVGtegRAIGVEHIPELVASSVKNIEAsaaspfLKEGSLAVHVGDGRQGWAEFAPYDAIHVGAAAPEIPEALIDQLKPGG 183
Cdd:COG2518   87 LAG---RVYSVERDPELAERARERLAA------LGYDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEALLEQLAPGG 157

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 166899091 184 RLVIPVG-NIFQDLQVVDKNSDGsVSIKDETSVRYVPLT 221
Cdd:COG2518  158 RLVAPVGeGGVQRLVLITRTGDG-FERESLFEVRFVPLR 195
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
12-225 5.67e-59

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 185.02  E-value: 5.67e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  12 KNKAMVENLQNHGIVtSDEVAKAMEAVDRGVFVTD--RSSAYVDSPMSIGYNVTISAPHMHAMCLQLLEkhLKPGMRVLD 89
Cdd:PRK00312   8 RFARLVLRLRAEGIL-DERVLEAIEATPRELFVPEafKHKAYENRALPIGCGQTISQPYMVARMTELLE--LKPGDRVLE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  90 VGSGTGYLTACFAVMVGtegRAIGVEHIPELVASSVKNIEAsaaspfLKEGSLAVHVGDGRQGWAEFAPYDAIHVGAAAP 169
Cdd:PRK00312  85 IGTGSGYQAAVLAHLVR---RVFSVERIKTLQWEAKRRLKQ------LGLHNVSVRHGDGWKGWPAYAPFDRILVTAAAP 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 166899091 170 EIPEALIDQLKPGGRLVIPVGNIFQDLQVVDKNSDGSVSIKDETSVRYVPLTSREA 225
Cdd:PRK00312 156 EIPRALLEQLKEGGILVAPVGGEEQQLLTRVRKRGGRFEREVLEEVRFVPLVKGEL 211
PRK13944 PRK13944
protein-L-isoaspartate O-methyltransferase; Provisional
 14-220 4.42e-45

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 140001  Cd Length: 205  Bit Score: 149.58  E-value: 4.42e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  14 KAMVENLQNHGIVTSDEVAKAMEAVDRGVFVTD--RSSAYVDSPMSIGYNVTISAPHMHAMCLQLLEKhlKPGMRVLDVG 91
Cdd:PRK13944   3 KRLVEELVREGIIKSERVKKAMLSVPREEFVMPeyRMMAYEDRPLPLFAGATISAPHMVAMMCELIEP--RPGMKILEVG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  92 SGTGYLTACFAVMVGTEGRAIGVEHIPELVASSVKNIEASAASpflkeGSLAVHVGDGRQGWAEFAPYDAIHVGAAAPEI 171
Cdd:PRK13944  81 TGSGYQAAVCAEAIERRGKVYTVEIVKELAIYAAQNIERLGYW-----GVVEVYHGDGKRGLEKHAPFDAIIVTAAASTI 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 166899091 172 PEALIDQLKPGGRLVIPVG-NIFQDLQVVDKNSDGsVSIKDETSVRYVPL 220
Cdd:PRK13944 156 PSALVRQLKDGGVLVIPVEeGVGQVLYKVVKRGEK-VEKRAITYVLFVPL 204
methyltran_FxLD TIGR04364
methyltransferase, FxLD system; Members of this family resemble occur regularly in the ...
 15-189 6.08e-32

methyltransferase, FxLD system; Members of this family resemble occur regularly in the vicinity of lantibiotic biosynthesis enzymes and their probable target, the FxLD family of putative ribosomal natural product precursor (TIGR04363). Members resemble protein-L-isoaspartate O-methyltransferase (TIGR00080) and a predicted methyltranserase, TIGR04188, of another putative peptide modification system.


Pssm-ID: 275158  Cd Length: 394  Bit Score: 119.78  E-value: 6.08e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   15 AMVENLQNHGIVTSDEVAKAMEAVDRGVFV--TDRSSAYV----------DSPMSIGynvTISAPHMHAMCLQLLEkhLK 82
Cdd:TIGR04364   7 ALVDELREDGVIRSPRVEAAFRTVPRHLFApgAPLEKAYAanravvtkrdEDGRALS---SVSAPHIQAMMLEQAG--VE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   83 PGMRVLDVGSGtGYLTACFAVMVGTEGRAIGVEHIPELVASSVKNIEASaaspflkeGSLAVHV--GDGRQGWAEFAPYD 160
Cdd:TIGR04364  82 PGMRVLEIGSG-GYNAALLAELVGPSGEVTTVDIDEDVTDRARACLAAA--------GYPQVTVvlADAEAGVPELAPYD 152

                         170       180
                  ....*....|....*....|....*....
gi 166899091  161 AIHVGAAAPEIPEALIDQLKPGGRLVIPV 189
Cdd:TIGR04364 153 RIIVTVGAWDIPPAWLDQLAPGGRLVVPL 181
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 20-205 9.51e-26

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 102.23  E-value: 9.51e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  20 LQNHGIvtSDEVAKAMEAVDRGVFVTdrssayVDSPMSIGYNVTI-------------SAPHMHAMCLQLLekHLKPGMR 86
Cdd:PRK13943  14 LKKYGI--SDHIAKAFLEVPREEFLT------KSYPLSYVYEDIVlvsyddgeeystsSQPSLMALFMEWV--GLDKGMR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  87 VLDVGSGTGYLTACFAVMVGTEGRAIGVEHIPELVASSVKNIEAsaaspfLKEGSLAVHVGDGRQGWAEFAPYDAIHVGA 166
Cdd:PRK13943  84 VLEIGGGTGYNAAVMSRVVGEKGLVVSVEYSRKICEIAKRNVRR------LGIENVIFVCGDGYYGVPEFAPYDVIFVTV 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 166899091 167 AAPEIPEALIDQLKPGGRLVIPVGNIFQDLQ---VVDKNSDG 205
Cdd:PRK13943 158 GVDEVPETWFTQLKEGGRVIVPINLKLSRRQpafLFKKKDPY 199
methyltr_grsp TIGR04188
methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are ...
 16-190 1.41e-19

methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).


Pssm-ID: 275041  Cd Length: 363  Bit Score: 85.87  E-value: 1.41e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   16 MVENLQNHGIVTSDEVAKAMEAVDRGVFV-------TDRSS-----------------AYVDSPMSIGYNVTISAPH--- 68
Cdd:TIGR04188   1 LAARLAAAGVLTDPAWREAVEAVPRHLFLpgfftqlPDGRGwrpvtadrpdpdewlalVYSDETLVTQLDGDLAADAagg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   69 ---------------MHAMcLQLLEkhLKPGMRVLDVGSGTGYLTACFAVMVGtEGRAIGVEHIPELVASSVKNIEASAA 133
Cdd:TIGR04188  81 pvtgrptssstqpslVARM-LEALD--VEDGHRVLEIGTGTGYSAALLCHRLG-DDNVTSVEVDPGLAARAASALAAAGY 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 166899091  134 SPflkegslAVHVGDGRQGWAEFAPYDAIHVGAAAPEIPEALIDQLKPGGRLVIPVG 190
Cdd:TIGR04188 157 AP-------TVVTGDGLLGHPPRAPYDRIIATCAVRRVPPAWLRQTRPGGVILTTLS 206
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 76-187 1.30e-11

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 60.71  E-value: 1.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  76 LLEKH-LKPGMRVLDVGSGTGYLTACFAVMVGTegRAIGVehipELVASSVKNIEASAASPFLkEGSLAVHVGDGRQGWA 154
Cdd:COG2230   43 ILRKLgLKPGMRVLDIGCGWGGLALYLARRYGV--RVTGV----TLSPEQLEYARERAAEAGL-ADRVEVRLADYRDLPA 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 166899091 155 EfAPYDAI-------HVGAAA-PEIPEALIDQLKPGGRLVI 187
Cdd:COG2230  116 D-GQFDAIvsigmfeHVGPENyPAYFAKVARLLKPGGRLLL 155
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
83-187 1.71e-11

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 58.68  E-value: 1.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  83 PGMRVLDVGSGTGYLTACFAVMVgTEGRAIGVEHIPELVAssvkniEASAASPflkegSLAVHVGDGRQgWAEFAPYDAI 162
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERF-PGARVTGVDLSPEMLA------RARARLP-----NVRFVVADLRD-LDPPEPFDLV 67

                         90       100       110
                 ....*....|....*....|....*....|.
gi 166899091 163 HVGAA---APEIPEAL---IDQLKPGGRLVI 187
Cdd:COG4106   68 VSNAAlhwLPDHAALLarlAAALAPGGVLAV 98
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 81-187 2.67e-11

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 61.33  E-value: 2.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  81 LKPGMRVLDVGSGTGYLTACFAVMVGTEGRAIGVEHIPELVASSVKNIEAsaaspFLKEGSLAVHVGDGRQGWAEfAPYD 160
Cdd:COG2519   89 IFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLER-----FGLPDNVELKLGDIREGIDE-GDVD 162

                         90       100
                 ....*....|....*....|....*...
gi 166899091 161 AIHVGAAAP-EIPEALIDQLKPGGRLVI 187
Cdd:COG2519  163 AVFLDMPDPwEALEAVAKALKPGGVLVA 190
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 75-187 6.42e-11

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 58.11  E-value: 6.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  75 QLLEKHLKPGMRVLDVGSGTGYLTACFAvmvgTEG-RAIGVEHIPELVAssvknieasAASPFLKEGSLAVHVGDGRQGW 153
Cdd:COG2227   16 ALLARLLPAGGRVLDVGCGTGRLALALA----RRGaDVTGVDISPEALE---------IARERAAELNVDFVQGDLEDLP 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 166899091 154 AEFAPYDAI-------HVGAAAPEIpEALIDQLKPGGRLVI 187
Cdd:COG2227   83 LEDGSFDLVicsevleHLPDPAALL-RELARLLKPGGLLLL 122
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
71-186 1.86e-10

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 59.42  E-value: 1.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  71 AMCLQLLEKHLKPGMRVLDVGSGTGYLtACFAVMVGTeGRAIGVEHIPELVASSVKNIEASAAspflkEGSLAVHVGDGR 150
Cdd:COG2264  136 RLCLEALEKLLKPGKTVLDVGCGSGIL-AIAAAKLGA-KRVLAVDIDPVAVEAARENAELNGV-----EDRIEVVLGDLL 208

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 166899091 151 QGwaefAPYD--------AIHVgAAAPEIPEAlidqLKPGGRLV 186
Cdd:COG2264  209 ED----GPYDlvvanilaNPLI-ELAPDLAAL----LKPGGYLI 243
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 75-197 3.60e-10

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 57.12  E-value: 3.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  75 QLLEKHL--KPGMRVLDVGSGTGYLtACFAVMVGTEGRAIGVEHIPELVASSVKNIEAsaasPFLKEGSlaVHVGDGRQG 152
Cdd:COG2813   39 RLLLEHLpePLGGRVLDLGCGYGVI-GLALAKRNPEARVTLVDVNARAVELARANAAA----NGLENVE--VLWSDGLSG 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 166899091 153 WAEfAPYDAI------HVGAAA-PEIPEALIDQ----LKPGGRLVIpVGNIFQDLQ 197
Cdd:COG2813  112 VPD-GSFDLIlsnppfHAGRAVdKEVAHALIADaarhLRPGGELWL-VANRHLPYE 165
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 81-187 2.13e-09

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 54.23  E-value: 2.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  81 LKPGMRVLDVGSGTGYLTACFAvmvGTEGRAIGVEHIPELVASSVKNIEASAAspflkegSLAVHVGDGRQgwAEFAP-- 158
Cdd:COG2226   20 LRPGARVLDLGCGTGRLALALA---ERGARVTGVDISPEMLELARERAAEAGL-------NVEFVVGDAED--LPFPDgs 87

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 166899091 159 YDAIHVGAAAPEIP--EALIDQ----LKPGGRLVI 187
Cdd:COG2226   88 FDLVISSFVLHHLPdpERALAEiarvLKPGGRLVV 122
PRK08317 PRK08317
hypothetical protein; Provisional
 71-187 3.94e-09

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 54.94  E-value: 3.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  71 AMCLQLLekHLKPGMRVLDVGSGTGYLTACFAVMVGTEGRAIGVEHIPELVASSVKNIEASAASPFLKEGSL-AVHVGDG 149
Cdd:PRK08317   9 ARTFELL--AVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAKERAAGLGPNVEFVRGDAdGLPFPDG 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 166899091 150 RqgwaefapYDAI-------HVgaaapEIPEALIDQ----LKPGGRLVI 187
Cdd:PRK08317  87 S--------FDAVrsdrvlqHL-----EDPARALAEiarvLRPGGRVVV 122
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 70-187 5.89e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 51.07  E-value: 5.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  70 HAMCLQLLEKHLKPGMRVLDVGSGTGYLTACFAVMVGteGRAIGVEHIPELVAssvkniEASAASPFLKEGSLAVHVGDG 149
Cdd:COG0500   13 GLAALLALLERLPKGGRVLDLGCGTGRNLLALAARFG--GRVIGIDLSPEAIA------LARARAAKAGLGNVEFLVADL 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 166899091 150 RQGWA-EFAPYDAI-------HVGAAA-PEIPEALIDQLKPGGRLVI 187
Cdd:COG0500   85 AELDPlPAESFDLVvafgvlhHLPPEErEALLRELARALKPGGVLLL 131
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 75-213 1.41e-07

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 49.51  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   75 QLLEKHLK--PGMRVLDVGSGTGYLTACFAVMVGtEGRAIGVEHIPELVASSVKNIEASAASpflkegSLAVHVGDGRQG 152
Cdd:pfam05175  21 RLLLEHLPkdLSGKVLDLGCGAGVLGAALAKESP-DAELTMVDINARALESARENLAANGLE------NGEVVASDVYSG 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 166899091  153 WAEfAPYDAI------HVG-AAAPEIPEALI----DQLKPGGRLVIpVGNIFQDLQVVDKNSDGSVSIKDET 213
Cdd:pfam05175  94 VED-GKFDLIisnppfHAGlATTYNVAQRFIadakRHLRPGGELWI-VANRFLGYPPLLEELFGNVEVVAKT 163
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 64-189 1.49e-07

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 48.87  E-value: 1.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   64 ISAPHMHAMCLQLLEkhLKPGMRVLDVGSGTGYLTACFAVMVGtEGRAIGVEHIPElvasSVKNIEASAASpfLKEGSLA 143
Cdd:TIGR02469   2 MTKREVRALTLAKLR--LRPGDVLWDIGAGTGSVTIEAARLVP-NGRVYAIERNPE----ALDLIERNLRR--FGVSNIV 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 166899091  144 VHVGDgrqgwAEFAPY------DAIHVGAAA---PEIPEALIDQLKPGGRLVIPV 189
Cdd:TIGR02469  73 IVEGD-----APEAPEallpdpDAVFVGGSGgllQEILEAVERRLRPGGRIVLNA 122
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
71-186 1.53e-07

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 50.54  E-value: 1.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  71 AMCLQLLEKHLKPGMRVLDVGSGTGYLtacfavmvgtegrAI-----GVEHI------PELVASSVKNIEasaaspfLKE 139
Cdd:PRK00517 107 RLCLEALEKLVLPGKTVLDVGCGSGIL-------------AIaaaklGAKKVlavdidPQAVEAARENAE-------LNG 166

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 166899091 140 GSLAVHVGDGrqgwaeFAPYD--------AIHVgAAAPEIPEAlidqLKPGGRLV 186
Cdd:PRK00517 167 VELNVYLPQG------DLKADvivanilaNPLL-ELAPDLARL----LKPGGRLI 210
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 80-187 1.68e-07

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 50.94  E-value: 1.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  80 HLKPGMRVLDVGSGTGyltaCFAV---MVGTEGRAIGVEHIPELVASSVKNIEASAASPflkegsLAVHVGDGRQGWAEF 156
Cdd:COG2242  244 ALRPGDVLWDIGAGSG----SVSIeaaRLAPGGRVYAIERDPERAALIRANARRFGVPN------VEVVEGEAPEALADL 313

                         90       100       110
                 ....*....|....*....|....*....|....
gi 166899091 157 APYDAIHVGAAAPEIPE---ALIDQLKPGGRLVI 187
Cdd:COG2242  314 PDPDAVFIGGSGGNLPEileACWARLRPGGRLVA 347
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 74-204 2.48e-07

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 49.03  E-value: 2.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  74 LQLLEKHLKPGmRVLDVGSGTGYLTACFAVMVGTEGRAIGVEHIPELVASSVKNIEASAASPFLKegslaVHVGDGRQGW 153
Cdd:COG4122    8 LYLLARLLGAK-RILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAGLADRIR-----LILGDALEVL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 166899091 154 AEFA--PYDAIHVGAA---APEIPEALIDQLKPGGRLVIPvgNIFQDLQVVDKNSD 204
Cdd:COG4122   82 PRLAdgPFDLVFIDADksnYPDYLELALPLLRPGGLIVAD--NVLWHGRVADPARR 135
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 86-189 3.00e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 47.42  E-value: 3.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  86 RVLDVGSGTGYLTACFAVMVGteGRAIGVEHIPELVASSVKNIEAsaaspfLKEGSLAVHVGDGRQG-WAEFAPYDAI-- 162
Cdd:cd02440    1 RVLDLGCGTGALALALASGPG--ARVTGVDISPVALELARKAAAA------LLADNVEVLKGDAEELpPEADESFDVIis 72

                         90       100       110
                 ....*....|....*....|....*....|..
gi 166899091 163 -HVGAAAPEIPEALIDQ----LKPGGRLVIPV 189
Cdd:cd02440   73 dPPLHHLVEDLARFLEEarrlLKPGGVLVLTL 104
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 81-187 3.89e-07

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 48.18  E-value: 3.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   81 LKPGMRVLDVGSGTGYLTACFAVMVGTEGRAIGVEHIPELVASSVKNieasAASPFLKEgsLAVHVGDgrqgWAEF---- 156
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKAREN----AQKLGFDN--VEFEQGD----IEELpell 70

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 166899091  157 --APYDAIH---VGAAAPEIPEAL---IDQLKPGGRLVI 187
Cdd:pfam13847  71 edDKFDVVIsncVLNHIPDPDKVLqeiLRVLKPGGRLII 109
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 74-189 5.80e-07

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 48.25  E-value: 5.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  74 LQLLEKHLKPGMRVLDVGSGTGYLTACFAVMVGTEGRAIGVEHIPELVASSVKNIEAsaaspFLKEGSLAVHVGDGRQGW 153
Cdd:PRK00377  31 LALSKLRLRKGDMILDIGCGTGSVTVEASLLVGETGKVYAVDKDEKAINLTRRNAEK-----FGVLNNIVLIKGEAPEIL 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 166899091 154 AEFAP-YDAIHVGAAAPEIPE---ALIDQLKPGGRLVIPV 189
Cdd:PRK00377 106 FTINEkFDRIFIGGGSEKLKEiisASWEIIKKGGRIVIDA 145
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 71-187 6.28e-07

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 48.80  E-value: 6.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   71 AMCLQLLEKHLKPGMRVLDVGSGTGYLtACFAVMVGTEgRAIGVEHIPELVASSVKNIEASAASPflkegSLAVHV-GDG 149
Cdd:pfam06325 149 KLCLEALERLVKPGESVLDVGCGSGIL-AIAALKLGAK-KVVGVDIDPVAVRAAKENAELNGVEA-----RLEVYLpGDL 221

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 166899091  150 RQGwaefaPYDAIhVGAAAPEIPEALIDQ----LKPGGRLVI 187
Cdd:pfam06325 222 PKE-----KADVV-VANILADPLIELAPDiyalVKPGGYLIL 257
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 87-183 1.52e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 45.25  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   87 VLDVGSGTGYLTACFAVMVGteGRAIGVEHIPELVASSVKNIEASAAspflkegSLAVHVGDGRQGWAEFAPYDAIHVGA 166
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGG--ARVTGVDLSPEMLERARERAAEAGL-------NVEFVQGDAEDLPFPDGSFDLVVSSG 71

                          90       100
                  ....*....|....*....|....*
gi 166899091  167 A----APEIPEALIDQ----LKPGG 183
Cdd:pfam13649  72 VlhhlPDPDLEAALREiarvLKPGG 96
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 82-187 1.49e-05

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 44.56  E-value: 1.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   82 KPGMRVLDVGSGTGYLTACFAVMVGTEGRAIGVEHIPELVASSVKNIEASAASPFLKEGSLAVHVGDgrqgwaefAPYDA 161
Cdd:TIGR01934  38 FKGQKVLDVACGTGDLAIELAKSAPDRGKVTGVDFSSEMLEVAKKKSELPLNIEFIQADAEALPFED--------NSFDA 109

                          90       100       110
                  ....*....|....*....|....*....|..
gi 166899091  162 IHVGAA---APEIPEAL---IDQLKPGGRLVI 187
Cdd:TIGR01934 110 VTIAFGlrnVTDIQKALremYRVLKPGGRLVI 141
arsM PRK11873
arsenite methyltransferase;
81-129 2.33e-05

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 44.17  E-value: 2.33e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 166899091  81 LKPGMRVLDVGSGTGYltACF--AVMVGTEGRAIGVEHIPELVASSVKNIE 129
Cdd:PRK11873  75 LKPGETVLDLGSGGGF--DCFlaARRVGPTGKVIGVDMTPEMLAKARANAR 123
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
75-187 2.92e-05

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 43.06  E-value: 2.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  75 QLLEKHL-KPGMRVLDVGSGTGYLTACFAVMVgteGRAIGVEHIPELVAssvkniEASAaspflKEGSLAVHVGDGRQGW 153
Cdd:COG4976   37 ELLARLPpGPFGRVLDLGCGTGLLGEALRPRG---YRLTGVDLSEEMLA------KARE-----KGVYDRLLVADLADLA 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 166899091 154 AEFAPYDAI---HVGAAAPEIPEALI---DQLKPGGRLVI 187
Cdd:COG4976  103 EPDGRFDLIvaaDVLTYLGDLAAVFAgvaRALKPGGLFIF 142
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 80-187 5.28e-05

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 42.24  E-value: 5.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  80 HLKPGMRVLD--VGSGTgylTACFAVMVGteGRAIGVEHIPELVASSVKNIEasaaspFLKEGSLAVHVGDGRQGWAEFA 157
Cdd:COG1041   23 GAKEGDTVLDpfCGTGT---ILIEAGLLG--RRVIGSDIDPKMVEGARENLE------HYGYEDADVIRGDARDLPLADE 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 166899091 158 PYDAI----------HVGAAAPE------IPEALiDQLKPGGRLVI 187
Cdd:COG1041   92 SVDAIvtdppygrssKISGEELLelyekaLEEAA-RVLKPGGRVVI 136
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
60-130 5.35e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 43.10  E-value: 5.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  60 YNVTISAPHMHAMCL----------QLLEKHLKPGMRVLDVGSGTGyLTACFAVMVGTEgRAIGVEHIPELVASSVKNIE 129
Cdd:COG4076    2 YLMQFFVPRWHHPMLndverndafkAAIERVVKPGDVVLDIGTGSG-LLSMLAARAGAK-KVYAVEVNPDIAAVARRIIA 79


                 .
gi 166899091 130 A 130
Cdd:COG4076   80 A 80
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 74-187 2.16e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 40.49  E-value: 2.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   74 LQLLEKHLKPGMRVLDVGSGTGYLTACFavmvgtegRAIGVehipelvasSVKNIEASAASPFlKEGSLAVHVGDGRQGW 153
Cdd:pfam13489  13 LLRLLPKLPSPGRVLDFGCGTGIFLRLL--------RAQGF---------SVTGVDPSPIAIE-RALLNVRFDQFDEQEA 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 166899091  154 AEFA-PYDAI-------HVgaaaPEIPEAL---IDQLKPGGRLVI 187
Cdd:pfam13489  75 AVPAgKFDVIvarevleHV----PDPPALLrqiAALLKPGGLLLL 115
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 81-187 2.96e-04

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 40.90  E-value: 2.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  81 LKPGMRVLDVGSGTGYLTACFAVMVGtEGRAIGVEHIPELVASSVKNIeasAASPFlkEGSLAVHVGDGRQGWAEFAP-- 158
Cdd:COG4123   35 VKKGGRVLDLGTGTGVIALMLAQRSP-GARITGVEIQPEAAELARRNV---ALNGL--EDRITVIHGDLKEFAAELPPgs 108

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 166899091 159 YDAI---------HVGAAAP---------EIP---EALIDQ----LKPGGRLVI 187
Cdd:COG4123  109 FDLVvsnppyfkaGSGRKSPdearaiarhEDAltlEDLIRAaarlLKPGGRFAL 162
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 81-187 4.66e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 40.14  E-value: 4.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  81 LKPGMRVLDVGSGTGYLTACFAVMVGTEGRAIGVE------------HIPELVASSVKNIEASAAS-PFlKEGSlavhvg 147
Cdd:PRK00216  49 VRPGDKVLDLACGTGDLAIALAKAVGKTGEVVGLDfsegmlavgrekLRDLGLSGNVEFVQGDAEAlPF-PDNS------ 121

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 166899091 148 dgrqgwaefapYDAIHVGAA---APEIPEALidQ-----LKPGGRLVI 187
Cdd:PRK00216 122 -----------FDAVTIAFGlrnVPDIDKAL--RemyrvLKPGGRLVI 156
PRK14968 PRK14968
putative methyltransferase; Provisional
 82-115 1.99e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 37.96  E-value: 1.99e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 166899091  82 KPGMRVLDVGSGTGYLTACFAVMvgtEGRAIGVE 115
Cdd:PRK14968  22 KKGDRVLEVGTGSGIVAIVAAKN---GKKVVGVD 52
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 76-187 6.43e-03

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 36.92  E-value: 6.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091   76 LLEK-HLKPGMRVLDVGSGTGYLtACFAVM---VGTEGRAIGVEHIpELVASSVKNIEasaaSPFLKEGSLavhvgdgrQ 151
Cdd:pfam02353  53 ILDKlGLKPGMTLLDIGCGWGGL-MRRAAErydVNVVGLTLSKNQY-KLARKRVAAEG----LARKVEVLL--------Q 118

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 166899091  152 GWAEFA-PYDAI-------HVGAAA-PEIPEALIDQLKPGGRLVI 187
Cdd:pfam02353 119 DYRDFDePFDRIvsvgmfeHVGHENyDTFFKKLYNLLPPGGLMLL 163
PRK07402 PRK07402
precorrin-6Y C5,15-methyltransferase subunit CbiT;
81-192 9.86e-03

precorrin-6Y C5,15-methyltransferase subunit CbiT;


Pssm-ID: 180961  Cd Length: 196  Bit Score: 35.74  E-value: 9.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166899091  81 LKPGMRVLDVGSGTGYLtacfAVMVG---TEGRAIGVEHIPELVA--------SSVKNIEasaaspflkegslaVHVGDG 149
Cdd:PRK07402  38 LEPDSVLWDIGAGTGTI----PVEAGllcPKGRVIAIERDEEVVNlirrncdrFGVKNVE--------------VIEGSA 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 166899091 150 RQGWAEFAPYD---AIHVGAAAPEIPEALIDQLKPGGRLVIPVGNI 192
Cdd:PRK07402 100 PECLAQLAPAPdrvCIEGGRPIKEILQAVWQYLKPGGRLVATASSL 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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