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Conserved domains on  [gi|97219124|sp|Q3US17|]
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RecName: Full=Zinc finger protein 48; AltName: Full=Zinc finger protein 553

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11986977)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
161-572 6.38e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 6.38e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 161 RPTICGECGKSFRQSSDLVKHQRTHTGEKPYKCG--ICGKGFGDSSARIKHQRTHRGDQlprpvvprRQPSPAAPAAPHR 238
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNP--------SDLNSKSLPLSNS 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 239 PKAQDKPYICTDCGKRFVLSCSLLSHQRSHlgpKPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLC--------PECGKG 310
Cdd:COG5048 104 KASSSSLSSSSSNSNDNNLLSSHSLPPSSR---DPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKDP 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 311 FADSSARVKHLRTHSGQRPHACPECNRSFSLSSTLLRHRLTH-VEPQDFSLAAYPVVPLIPSPPPPPLGTSPSLTPRSPS 389
Cdd:COG5048 181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 390 HSSDGPFGLPGLEPepggPQAGEPPPPLAGDKPHKCPECGKGFRRSSDLVKH--HRVHTGE--KPYLCPE--CGKGFADS 463
Cdd:COG5048 261 PRSSLPTASSQSSS----PNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRN 336

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 464 SARVKHLRTHQGerTRPPPPPSTLLRPHNPPGSVPIVPQSRVQGRPSGPSQLHVC--GFCGKEFPRSSDLVKHRRTHTGE 541
Cdd:COG5048 337 DALKRHILLHTS--ISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSF 414

                       410       420       430
                ....*....|....*....|....*....|...
gi 97219124 542 KP--YKCAECGKGFGDSSARIKHQRGHLALKPF 572
Cdd:COG5048 415 RPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447
zf-H2C2_2 pfam13465
Zinc-finger double domain;
97-120 2.35e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.35e-04
                          10        20
                  ....*....|....*....|....
gi 97219124    97 DLVKHQRTHTGEKPYKCGVCGKGF 120
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 84-105 3.34e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.34e-03
                          10        20
                  ....*....|....*....|..
gi 97219124    84 VCGECGKSFRQMSDLVKHQRTH 105
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
161-572 6.38e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 6.38e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 161 RPTICGECGKSFRQSSDLVKHQRTHTGEKPYKCG--ICGKGFGDSSARIKHQRTHRGDQlprpvvprRQPSPAAPAAPHR 238
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNP--------SDLNSKSLPLSNS 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 239 PKAQDKPYICTDCGKRFVLSCSLLSHQRSHlgpKPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLC--------PECGKG 310
Cdd:COG5048 104 KASSSSLSSSSSNSNDNNLLSSHSLPPSSR---DPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKDP 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 311 FADSSARVKHLRTHSGQRPHACPECNRSFSLSSTLLRHRLTH-VEPQDFSLAAYPVVPLIPSPPPPPLGTSPSLTPRSPS 389
Cdd:COG5048 181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 390 HSSDGPFGLPGLEPepggPQAGEPPPPLAGDKPHKCPECGKGFRRSSDLVKH--HRVHTGE--KPYLCPE--CGKGFADS 463
Cdd:COG5048 261 PRSSLPTASSQSSS----PNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRN 336

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 464 SARVKHLRTHQGerTRPPPPPSTLLRPHNPPGSVPIVPQSRVQGRPSGPSQLHVC--GFCGKEFPRSSDLVKHRRTHTGE 541
Cdd:COG5048 337 DALKRHILLHTS--ISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSF 414

                       410       420       430
                ....*....|....*....|....*....|...
gi 97219124 542 KP--YKCAECGKGFGDSSARIKHQRGHLALKPF 572
Cdd:COG5048 415 RPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447
zf-H2C2_2 pfam13465
Zinc-finger double domain;
530-553 1.48e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.48e-04
                          10        20
                  ....*....|....*....|....
gi 97219124   530 DLVKHRRTHTGEKPYKCAECGKGF 553
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
97-120 2.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.35e-04
                          10        20
                  ....*....|....*....|....
gi 97219124    97 DLVKHQRTHTGEKPYKCGVCGKGF 120
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 84-105 3.34e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.34e-03
                          10        20
                  ....*....|....*....|..
gi 97219124    84 VCGECGKSFRQMSDLVKHQRTH 105
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
161-572 6.38e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 6.38e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 161 RPTICGECGKSFRQSSDLVKHQRTHTGEKPYKCG--ICGKGFGDSSARIKHQRTHRGDQlprpvvprRQPSPAAPAAPHR 238
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNP--------SDLNSKSLPLSNS 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 239 PKAQDKPYICTDCGKRFVLSCSLLSHQRSHlgpKPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLC--------PECGKG 310
Cdd:COG5048 104 KASSSSLSSSSSNSNDNNLLSSHSLPPSSR---DPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKDP 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 311 FADSSARVKHLRTHSGQRPHACPECNRSFSLSSTLLRHRLTH-VEPQDFSLAAYPVVPLIPSPPPPPLGTSPSLTPRSPS 389
Cdd:COG5048 181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 390 HSSDGPFGLPGLEPepggPQAGEPPPPLAGDKPHKCPECGKGFRRSSDLVKH--HRVHTGE--KPYLCPE--CGKGFADS 463
Cdd:COG5048 261 PRSSLPTASSQSSS----PNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRN 336

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 464 SARVKHLRTHQGerTRPPPPPSTLLRPHNPPGSVPIVPQSRVQGRPSGPSQLHVC--GFCGKEFPRSSDLVKHRRTHTGE 541
Cdd:COG5048 337 DALKRHILLHTS--ISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSF 414

                       410       420       430
                ....*....|....*....|....*....|...
gi 97219124 542 KP--YKCAECGKGFGDSSARIKHQRGHLALKPF 572
Cdd:COG5048 415 RPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
258-471 2.74e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 2.74e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 258 SCSLLSHQRSHLGP-----KPFGCDVCGKEFARGSDLVKHLR--VHTGE--KPYLCPE--CGKGFADSSARVKHLRTHSG 326
Cdd:COG5048 269 SSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 327 QRPHACPECNRSFSLSStllrhRLTHVEPQDFSLaaypvvplipspppppLGTSPSLTPRSPSHSSDgpfglpgLEPEPG 406
Cdd:COG5048 349 ISPAKEKLLNSSSKFSP-----LLNNEPPQSLQQ----------------YKDLKNDKKSETLSNSC-------IRNFKR 400

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 97219124 407 GPQAGEPPPPLAGDKPH--KCPECGKGFRRSSDLVKHHRVHTgEKPYLCPECGKGFADSSARVKHLR 471
Cdd:COG5048 401 DSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
530-553 1.48e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.48e-04
                          10        20
                  ....*....|....*....|....
gi 97219124   530 DLVKHRRTHTGEKPYKCAECGKGF 553
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
271-572 1.54e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.54e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 271 PKPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLC--PECGKGFADSSARVKHLRTHSGQRPHACPECNR----------- 337
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsnskassssl 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 338 ----SFSLSSTLLRHRLTHVEPQDFSLAAYPVVPLIPSPPPPPLGTSPSLTPRSPSHSSDGPfGLPGLEPEPGGPQAGEP 413
Cdd:COG5048 111 ssssSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLP-ANSLSKDPSSNLSLLIS 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 414 PPPLAGDKPHKCPECGKGFRRSSDLVKHHRVHTGEKPYLCPECGKGFADSSarVKHLRTHQGERTRPPPPPSTLLRPHNP 493
Cdd:COG5048 190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSL--LSQSPSSLSSSDSSSSASESPRSSLPT 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 494 PGSVPIVPQSRVQGRPSGPSQLHVCGFCGKEFPRSSDLVKHRRT--HTGE--KPYKCAE--CGKGFGDSSARIKHQRGHL 567
Cdd:COG5048 268 ASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347


                ....*
gi 97219124 568 ALKPF 572
Cdd:COG5048 348 SISPA 352
zf-H2C2_2 pfam13465
Zinc-finger double domain;
288-312 1.54e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.54e-04
                          10        20
                  ....*....|....*....|....*
gi 97219124   288 DLVKHLRVHTGEKPYLCPECGKGFA 312
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
85-557 1.91e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.91e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124  85 CGECGKSFRQMSDLVKHQRTHTGEKPYKCGV--CGKGFGDSSARIKHQRTHTGEKAYRVRPPAPGPPKMPRSRIPAG--- 159
Cdd:COG5048  36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSsss 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 160 ERPTICGECGKSFRQSSDLVKH----QRTHTGEKPYKCGICGKGFGDSSARIKHQRT---HRGDQLPRPVVPRRQPSPAA 232
Cdd:COG5048 116 NSNDNNLLSSHSLPPSSRDPQLpdllSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPansLSKDPSSNLSLLISSNVSTS 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 233 PAAPHRPKAQDKPYI----CTDCGKRFVLScSLLSHQRSHLGPKPFgcdvcgkEFARGSDLVKHLRVHTGEKPYLCPECG 308
Cdd:COG5048 196 IPSSSENSPLSSSYSipssSSDQNLENSSS-SLPLTTNSQLSPKSL-------LSQSPSSLSSSDSSSSASESPRSSLPT 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 309 KGFADSSARVKHLRTHSGQR-PHACPECNRSFSLSSTLLRHRlthvepqdfslaaypvvplipsppppplgtspsltpRS 387
Cdd:COG5048 268 ASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHL------------------------------------RS 311

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 388 PSHSSDGpfglpglepepggpqagepppplagDKPHKCPE--CGKGFRRSSDLVKHHRVHTGEKPYLCP--ECGKGFADS 463
Cdd:COG5048 312 VNHSGES-------------------------LKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPL 366

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 97219124 464 SARVKHLRTHQgertrppPPPSTLLRPHNPPGSVPIVPQSRVQGRPSgPSQLHV--------CGFCGKEFPRSSDLVKHR 535
Cdd:COG5048 367 LNNEPPQSLQQ-------YKDLKNDKKSETLSNSCIRNFKRDSNLSL-HIITHLsfrpynckNPPCSKSFNRHYNLIPHK 438

                       490       500
                ....*....|....*....|..
gi 97219124 536 RTHTGEKPYKCAECGKGFGDSS 557
Cdd:COG5048 439 KIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
97-120 2.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.35e-04
                          10        20
                  ....*....|....*....|....
gi 97219124    97 DLVKHQRTHTGEKPYKCGVCGKGF 120
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 423-445 2.74e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 2.74e-04
                          10        20
                  ....*....|....*....|...
gi 97219124   423 HKCPECGKGFRRSSDLVKHHRVH 445
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
177-200 3.48e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.48e-04
                          10        20
                  ....*....|....*....|....
gi 97219124   177 DLVKHQRTHTGEKPYKCGICGKGF 200
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
437-461 4.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.95e-04
                          10        20
                  ....*....|....*....|....*
gi 97219124   437 DLVKHHRVHTGEKPYLCPECGKGFA 461
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 165-185 9.71e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 9.71e-04
                          10        20
                  ....*....|....*....|.
gi 97219124   165 CGECGKSFRQSSDLVKHQRTH 185
Cdd:pfam00096   3 CPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 84-105 3.34e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.34e-03
                          10        20
                  ....*....|....*....|..
gi 97219124    84 VCGECGKSFRQMSDLVKHQRTH 105
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 516-538 3.95e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.95e-03
                          10        20
                  ....*....|....*....|...
gi 97219124   516 HVCGFCGKEFPRSSDLVKHRRTH 538
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
319-340 6.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.55e-03
                          10        20
                  ....*....|....*....|..
gi 97219124   319 KHLRTHSGQRPHACPECNRSFS 340
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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