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Conserved domains on  [gi|94730691|sp|Q32M78|]
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RecName: Full=Zinc finger protein 699; AltName: Full=Hangover homolog

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 16584006)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
19-79 1.09e-29

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 111.53  E-value: 1.09e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 94730691     19 VVFEDVAVDFTQEEWALLDLAQRNLYRDVMLENFQNLASLGYPLHTPHLISQWEQEEDLQT 79
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
276-641 4.43e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.12  E-value: 4.43e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 276 KTNYECKECGKGFSCSSSLTEHKRIHSGDKPYEC--KECGKAFSCSSSLSKHKRIHSGDKPYEC-KECGKAFSSSSHLII 352
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 353 HIRIHTGEKPYECKECGKAFSESSKLTVHGRTHTGEKPYKCKEC-GKAYNCPSSLSIHM--------------------- 410
Cdd:COG5048 111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPplpanslskdpssnlslliss 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 411 RKHTGEKPYECLECGKAFYLPTSLNTHVKNQSREKPYECKECGKAFSC------PSSFRAHVRDHTGKIQYECKECGKTF 484
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASESPRSSLPTASS 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 485 SRSSSLTEHLRTHSG-EKPYECKECGKAFISSSHLTVHIRT--HTGE--KPYECKK--CGKAFIYPSALRIHMRTHTGEK 557
Cdd:COG5048 271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 558 PYECK--ECGKAFRHSSYLTVHARMH-----TGEKPFECL--ECGKAFSCPSSFRRHVRSHTGEKPYECK--ECGKAFVC 626
Cdd:COG5048 351 PAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                       410
                ....*....|....*
gi 94730691 627 PAYFRRHVKTHTREN 641
Cdd:COG5048 431 HYNLIPHKKIHTNHA 445
zf-H2C2_2 pfam13465
Zinc-finger double domain;
209-232 7.35e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.35e-04
                          10        20
                  ....*....|....*....|....
gi 94730691   209 SLKSHIRSHTGSKPYQCKECGKAF 232
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
118-326 4.36e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 4.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 118 SNEQKIVRFKRNDSWFSSLHENQESCgidyqNKSHERHLRNHMVENIYECYeeNQDGQTFSQVPNLDSLKRNTEVKSCEC 197
Cdd:COG5048 254 SSSASESPRSSLPTASSQSSSPNESD-----SSSEKGFSLPIKSKQCNISF--SRSSPLTRHLRSVNHSGESLKPFSCPY 326

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 198 HECGKAFVDHSSLKSHIRSHTGSKPYQCKECGKAFHFLACFKK-------HMKTPTEEKPYEC--KECTKAFSCSSFFRA 268
Cdd:COG5048 327 SLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSL 406

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 269 HMKIHIGKTNYECK--ECGKGFSCSSSLTEHKRIHSGDKPYECKECGKAFSCSSSLSKHK 326
Cdd:COG5048 407 HIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
19-79 1.09e-29

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 111.53  E-value: 1.09e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 94730691     19 VVFEDVAVDFTQEEWALLDLAQRNLYRDVMLENFQNLASLGYPLHTPHLISQWEQEEDLQT 79
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 18-59 2.33e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 98.70  E-value: 2.33e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 94730691    18 SVVFEDVAVDFTQEEWALLDLAQRNLYRDVMLENFQNLASLG 59
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 21-58 2.76e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 84.14  E-value: 2.76e-20
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 94730691  21 FEDVAVDFTQEEWALLDLAQRNLYRDVMLENFQNLASL 58
Cdd:cd07765   3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
276-641 4.43e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.12  E-value: 4.43e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 276 KTNYECKECGKGFSCSSSLTEHKRIHSGDKPYEC--KECGKAFSCSSSLSKHKRIHSGDKPYEC-KECGKAFSSSSHLII 352
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 353 HIRIHTGEKPYECKECGKAFSESSKLTVHGRTHTGEKPYKCKEC-GKAYNCPSSLSIHM--------------------- 410
Cdd:COG5048 111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPplpanslskdpssnlslliss 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 411 RKHTGEKPYECLECGKAFYLPTSLNTHVKNQSREKPYECKECGKAFSC------PSSFRAHVRDHTGKIQYECKECGKTF 484
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASESPRSSLPTASS 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 485 SRSSSLTEHLRTHSG-EKPYECKECGKAFISSSHLTVHIRT--HTGE--KPYECKK--CGKAFIYPSALRIHMRTHTGEK 557
Cdd:COG5048 271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 558 PYECK--ECGKAFRHSSYLTVHARMH-----TGEKPFECL--ECGKAFSCPSSFRRHVRSHTGEKPYECK--ECGKAFVC 626
Cdd:COG5048 351 PAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                       410
                ....*....|....*
gi 94730691 627 PAYFRRHVKTHTREN 641
Cdd:COG5048 431 HYNLIPHKKIHTNHA 445
zf-H2C2_2 pfam13465
Zinc-finger double domain;
545-570 7.47e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.47e-05
                          10        20
                  ....*....|....*....|....*.
gi 94730691   545 ALRIHMRTHTGEKPYECKECGKAFRH 570
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
209-232 7.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.35e-04
                          10        20
                  ....*....|....*....|....
gi 94730691   209 SLKSHIRSHTGSKPYQCKECGKAF 232
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
118-326 4.36e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 4.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 118 SNEQKIVRFKRNDSWFSSLHENQESCgidyqNKSHERHLRNHMVENIYECYeeNQDGQTFSQVPNLDSLKRNTEVKSCEC 197
Cdd:COG5048 254 SSSASESPRSSLPTASSQSSSPNESD-----SSSEKGFSLPIKSKQCNISF--SRSSPLTRHLRSVNHSGESLKPFSCPY 326

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 198 HECGKAFVDHSSLKSHIRSHTGSKPYQCKECGKAFHFLACFKK-------HMKTPTEEKPYEC--KECTKAFSCSSFFRA 268
Cdd:COG5048 327 SLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSL 406

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 269 HMKIHIGKTNYECK--ECGKGFSCSSSLTEHKRIHSGDKPYECKECGKAFSCSSSLSKHK 326
Cdd:COG5048 407 HIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
19-79 1.09e-29

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 111.53  E-value: 1.09e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 94730691     19 VVFEDVAVDFTQEEWALLDLAQRNLYRDVMLENFQNLASLGYPLHTPHLISQWEQEEDLQT 79
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 18-59 2.33e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 98.70  E-value: 2.33e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 94730691    18 SVVFEDVAVDFTQEEWALLDLAQRNLYRDVMLENFQNLASLG 59
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 21-58 2.76e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 84.14  E-value: 2.76e-20
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 94730691  21 FEDVAVDFTQEEWALLDLAQRNLYRDVMLENFQNLASL 58
Cdd:cd07765   3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
276-641 4.43e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.12  E-value: 4.43e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 276 KTNYECKECGKGFSCSSSLTEHKRIHSGDKPYEC--KECGKAFSCSSSLSKHKRIHSGDKPYEC-KECGKAFSSSSHLII 352
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 353 HIRIHTGEKPYECKECGKAFSESSKLTVHGRTHTGEKPYKCKEC-GKAYNCPSSLSIHM--------------------- 410
Cdd:COG5048 111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPplpanslskdpssnlslliss 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 411 RKHTGEKPYECLECGKAFYLPTSLNTHVKNQSREKPYECKECGKAFSC------PSSFRAHVRDHTGKIQYECKECGKTF 484
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASESPRSSLPTASS 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 485 SRSSSLTEHLRTHSG-EKPYECKECGKAFISSSHLTVHIRT--HTGE--KPYECKK--CGKAFIYPSALRIHMRTHTGEK 557
Cdd:COG5048 271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 558 PYECK--ECGKAFRHSSYLTVHARMH-----TGEKPFECL--ECGKAFSCPSSFRRHVRSHTGEKPYECK--ECGKAFVC 626
Cdd:COG5048 351 PAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                       410
                ....*....|....*
gi 94730691 627 PAYFRRHVKTHTREN 641
Cdd:COG5048 431 HYNLIPHKKIHTNHA 445
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-605 3.91e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 3.91e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 171 NQDGQTFSQVPNLDSLKRNTEVKSCECHECGKAFVDHSSLKSHIRSHTGSKPYQC--KECGKAFHFLACFKKHMKTPTEE 248
Cdd:COG5048  10 SSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNN 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 249 KPYECkeCTKAFSCSSFFRAHMKIHIGKT-NYECKECGKGFSCSSSLTEHKRIHSGDKPYECKECGKAFSCSSSLSKHKR 327
Cdd:COG5048  90 PSDLN--SKSLPLSNSKASSSSLSSSSSNsNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSL 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 328 IHSGDKPYECKEcgkAFSSSSHLIIHIRIHTGEKPYECKECGKAFSESSKLTVHGRTHTgEKPYKCKECGKAYNCPSSLS 407
Cdd:COG5048 168 HPPLPANSLSKD---PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQ 243

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 408 IHMRKHTGEKPYECLECGKAFYLPTSLNTH-------VKNQSREKPYECKECGKAFSCPSSFRAHVR--DHTGKIQYECK 478
Cdd:COG5048 244 SPSSLSSSDSSSSASESPRSSLPTASSQSSspnesdsSSEKGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFS 323

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 479 E----CGKTFSRSSSLTEHLRTHSGEKPYECKEC------GKAFISSSHLTVHIR-THTGEKPYEC--KKCGKAFIYPSA 545
Cdd:COG5048 324 CpyslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfSPLLNNEPPQSLQQYkDLKNDKKSETlsNSCIRNFKRDSN 403

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 94730691 546 LRIHMRTHTGEKPYECK--ECGKAFRHSSYLTVHARMHTGEKPFECLECGKAFSCPSSFRRH 605
Cdd:COG5048 404 LSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
154-533 3.61e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 3.61e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 154 RHLRNHMVENIYECYEENQDgQTFSQVPNL--DSLKRNTEVKSCECHECGKAFVDHSSLKSHIRSHTGSKPYQCKECGKA 231
Cdd:COG5048  51 RHIRSHTGEKPSQCSYSGCD-KSFSRPLELsrHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLP 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 232 FHFLACFKKHMKTPTEEKPYECKECTK-AFSCSSFFRAHMKIHIGKTnyeckeCGKGFSCSSSLTEHKRIHSGDKPYECK 310
Cdd:COG5048 130 PSSRDPQLPDLLSISNLRNNPLPGNNSsSVNTPQSNSLHPPLPANSL------SKDPSSNLSLLISSNVSTSIPSSSENS 203

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 311 ECGKAFSCSSSLSKHKRIHS-----GDKPYECKECGKAFSSSSHLIIHIRIHTGEKPYECKECGKAFSESSKLTVHGRTH 385
Cdd:COG5048 204 PLSSSYSIPSSSSDQNLENSssslpLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSE 283

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 386 TG-EKPYKCKECGKAYNCPSSLSIHMRK--HTGE--KPYECLE--CGKAFYLPTSLNTHVKNQSREKPYECKEC------ 452
Cdd:COG5048 284 KGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskf 363

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 453 -GKAFSCPSSFRAHVRDHTGKIQYEC--KECGKTFSRSSSLTEHLRTHSGEKPYECK--ECGKAFISSSHLTVHIRTHTG 527
Cdd:COG5048 364 sPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTN 443


                ....*.
gi 94730691 528 EKPYEC 533
Cdd:COG5048 444 HAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
545-570 7.47e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.47e-05
                          10        20
                  ....*....|....*....|....*.
gi 94730691   545 ALRIHMRTHTGEKPYECKECGKAFRH 570
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
601-626 1.53e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.53e-04
                          10        20
                  ....*....|....*....|....*.
gi 94730691   601 SFRRHVRSHTGEKPYECKECGKAFVC 626
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
517-542 7.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.00e-04
                          10        20
                  ....*....|....*....|....*.
gi 94730691   517 HLTVHIRTHTGEKPYECKKCGKAFIY 542
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
209-232 7.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.35e-04
                          10        20
                  ....*....|....*....|....
gi 94730691   209 SLKSHIRSHTGSKPYQCKECGKAF 232
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
321-346 1.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 94730691   321 SLSKHKRIHSGDKPYECKECGKAFSS 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
489-514 1.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.22e-03
                          10        20
                  ....*....|....*....|....*.
gi 94730691   489 SLTEHLRTHSGEKPYECKECGKAFIS 514
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
349-373 1.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.27e-03
                          10        20
                  ....*....|....*....|....*
gi 94730691   349 HLIIHIRIHTGEKPYECKECGKAFS 373
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
293-318 1.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.32e-03
                          10        20
                  ....*....|....*....|....*.
gi 94730691   293 SLTEHKRIHSGDKPYECKECGKAFSC 318
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
405-428 1.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.39e-03
                          10        20
                  ....*....|....*....|....
gi 94730691   405 SLSIHMRKHTGEKPYECLECGKAF 428
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 475-497 1.75e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.75e-03
                          10        20
                  ....*....|....*....|...
gi 94730691   475 YECKECGKTFSRSSSLTEHLRTH 497
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 503-525 2.84e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.84e-03
                          10        20
                  ....*....|....*....|...
gi 94730691   503 YECKECGKAFISSSHLTVHIRTH 525
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 335-357 3.04e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.04e-03
                          10        20
                  ....*....|....*....|...
gi 94730691   335 YECKECGKAFSSSSHLIIHIRIH 357
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
118-326 4.36e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 4.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 118 SNEQKIVRFKRNDSWFSSLHENQESCgidyqNKSHERHLRNHMVENIYECYeeNQDGQTFSQVPNLDSLKRNTEVKSCEC 197
Cdd:COG5048 254 SSSASESPRSSLPTASSQSSSPNESD-----SSSEKGFSLPIKSKQCNISF--SRSSPLTRHLRSVNHSGESLKPFSCPY 326

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 198 HECGKAFVDHSSLKSHIRSHTGSKPYQCKECGKAFHFLACFKK-------HMKTPTEEKPYEC--KECTKAFSCSSFFRA 268
Cdd:COG5048 327 SLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSL 406

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 94730691 269 HMKIHIGKTNYECK--ECGKGFSCSSSLTEHKRIHSGDKPYECKECGKAFSCSSSLSKHK 326
Cdd:COG5048 407 HIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
573-598 4.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.99e-03
                          10        20
                  ....*....|....*....|....*.
gi 94730691   573 YLTVHARMHTGEKPFECLECGKAFSC 598
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 531-553 6.53e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.53e-03
                          10        20
                  ....*....|....*....|...
gi 94730691   531 YECKKCGKAFIYPSALRIHMRTH 553
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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