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Conserved domains on  [gi|123912758|sp|Q1LUT1|]
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RecName: Full=Enhancer of mRNA-decapping protein 4

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ge1_WD40 super family cl25640
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 112-437 3.79e-167

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


The actual alignment was detected with superfamily member pfam16529:

Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 502.37  E-value: 3.79e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758   112 GSNKVKIQPVAKYDWEHKYYYGNLIAV--SNTYLAYAIRGANNHSMIRVLHLSSTERSLLKGFTGAVTDLAFAHLDSTLL 189
Cdd:pfam16529    1 GSSKVKLKNIVDYKWERKYYPGQLVAVhrDGKYLAYAIKVKNGGGMVRVINIETSERALLKGMTGEVLDLAFAHTDCVIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758   190 GCVDEAGNMFIWQLTSHSSKIQDEVIVHIRRPEDTPLNSNRRLIWCPFIPEDNDE--SPEDACQTLALLHEDRAEVWDLD 267
Cdd:pfam16529   81 ACVDDVGNLFVYKVDQIEGKILCNLLLHIEDPIGTYPSEYHRVIWCPYIPEDDETesDDDDESKLLVLLRGDKAEIWNVD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758   268 ILRSNNSSWPVDATELKEGFITIRGHAaRISEGALSPDGTVLATASHDGYVKFWQIYIEGQDQPRCLHEWQPHNGQPLSC 347
Cdd:pfam16529  161 MIVSEHGSGPLQPAALESGYIEIEEHS-LLVDAAFSPDGTALATASLDGEVKFFQIYLFDNRNPRCLHEWKPHDGKPLSS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758   348 LLFCDNHKKQdPDVPFWRFLITGADQNQELKMWCTVSWTCLQTIRFSPDPFNCGVLPSLKASLDLSAEFLILSDVQRKVL 427
Cdd:pfam16529  240 LFFLDNHKKP-PEVQFWRFAITGADNNSELKLWSCESWTCLQTIRFVPDPPSSLQPPNLKAGLDLSANYLVLSDLDNKVL 318

                          330
                   ....*....|
gi 123912758   428 YVMELLQDQE 437
Cdd:pfam16529  319 YVLQLGQDGE 328
 
Name Accession Description Interval E-value
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 112-437 3.79e-167

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 502.37  E-value: 3.79e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758   112 GSNKVKIQPVAKYDWEHKYYYGNLIAV--SNTYLAYAIRGANNHSMIRVLHLSSTERSLLKGFTGAVTDLAFAHLDSTLL 189
Cdd:pfam16529    1 GSSKVKLKNIVDYKWERKYYPGQLVAVhrDGKYLAYAIKVKNGGGMVRVINIETSERALLKGMTGEVLDLAFAHTDCVIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758   190 GCVDEAGNMFIWQLTSHSSKIQDEVIVHIRRPEDTPLNSNRRLIWCPFIPEDNDE--SPEDACQTLALLHEDRAEVWDLD 267
Cdd:pfam16529   81 ACVDDVGNLFVYKVDQIEGKILCNLLLHIEDPIGTYPSEYHRVIWCPYIPEDDETesDDDDESKLLVLLRGDKAEIWNVD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758   268 ILRSNNSSWPVDATELKEGFITIRGHAaRISEGALSPDGTVLATASHDGYVKFWQIYIEGQDQPRCLHEWQPHNGQPLSC 347
Cdd:pfam16529  161 MIVSEHGSGPLQPAALESGYIEIEEHS-LLVDAAFSPDGTALATASLDGEVKFFQIYLFDNRNPRCLHEWKPHDGKPLSS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758   348 LLFCDNHKKQdPDVPFWRFLITGADQNQELKMWCTVSWTCLQTIRFSPDPFNCGVLPSLKASLDLSAEFLILSDVQRKVL 427
Cdd:pfam16529  240 LFFLDNHKKP-PEVQFWRFAITGADNNSELKLWSCESWTCLQTIRFVPDPPSSLQPPNLKAGLDLSANYLVLSDLDNKVL 318

                          330
                   ....*....|
gi 123912758   428 YVMELLQDQE 437
Cdd:pfam16529  319 YVLQLGQDGE 328
WD40 COG2319
WD40 repeat [General function prediction only];
156-396 3.93e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.86  E-value: 3.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  156 IRVLHLSS-TERSLLKGFTGAVTDLAFAHlDSTLLGCVDEAGNMFIWQLTShsskiqdevivhirRPEDTPLNSNRRLIW 234
Cdd:COG2319   186 VRLWDLATgKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT--------------GKLLRTLTGHSGSVR 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  235 CPFIpedndeSPEDacQTLALLHEDR-AEVWDLDilrsnnsswpvDATELKegfiTIRGHAARISEGALSPDGTVLATAS 313
Cdd:COG2319   251 SVAF------SPDG--RLLASGSADGtVRLWDLA-----------TGELLR----TLTGHSGGVNSVAFSPDGKLLASGS 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  314 HDGYVKFWQIyiegqDQPRCLHEWQPHNGQPLScLLFcdnhkkqDPDVpfwRFLITGADQNQeLKMWCTVSWTCLQTIR- 392
Cdd:COG2319   308 DDGTVRLWDL-----ATGKLLRTLTGHTGAVRS-VAF-------SPDG---KTLASGSDDGT-VRLWDLATGELLRTLTg 370

                         250
                  ....*....|...
gi 123912758  393 ---------FSPD 396
Cdd:COG2319   371 htgavtsvaFSPD 383
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 169-400 7.22e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.58  E-value: 7.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  169 LKGFTGAVTDLAFaHLDSTLL--GCVDeaGNMFIWQLTSHSSKIQDEVivHIRrpedtplnSNRRLIWCPFIP------E 240
Cdd:cd00200     5 LKGHTGGVTCVAF-SPDGKLLatGSGD--GTIKVWDLETGELLRTLKG--HTG--------PVRDVAASADGTylasgsS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  241 DN-----DESPEDACQTLALlHEDraEVWDLDILRSNN----SS-------WPVDATELKegfITIRGHAARISEGALSP 304
Cdd:cd00200    72 DKtirlwDLETGECVRTLTG-HTS--YVSSVAFSPDGRilssSSrdktikvWDVETGKCL---TTLRGHTDWVNSVAFSP 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  305 DGTVLATASHDGYVKFWQIyiegqDQPRCLHEWQPHNGqPLSCLLFCDNHKKqdpdvpfwrfLITGADqNQELKMWCTVS 384
Cdd:cd00200   146 DGTFVASSSQDGTIKLWDL-----RTGKCVATLTGHTG-EVNSVAFSPDGEK----------LLSSSS-DGTIKLWDLST 208

                         250
                  ....*....|....*.
gi 123912758  385 WTCLQTIRFSPDPFNC 400
Cdd:cd00200   209 GKCLGTLRGHENGVNS 224
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 289-321 1.66e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 1.66e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 123912758    289 TIRGHAARISEGALSPDGTVLATASHDGYVKFW 321
Cdd:smart00320    7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 112-437 3.79e-167

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 502.37  E-value: 3.79e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758   112 GSNKVKIQPVAKYDWEHKYYYGNLIAV--SNTYLAYAIRGANNHSMIRVLHLSSTERSLLKGFTGAVTDLAFAHLDSTLL 189
Cdd:pfam16529    1 GSSKVKLKNIVDYKWERKYYPGQLVAVhrDGKYLAYAIKVKNGGGMVRVINIETSERALLKGMTGEVLDLAFAHTDCVIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758   190 GCVDEAGNMFIWQLTSHSSKIQDEVIVHIRRPEDTPLNSNRRLIWCPFIPEDNDE--SPEDACQTLALLHEDRAEVWDLD 267
Cdd:pfam16529   81 ACVDDVGNLFVYKVDQIEGKILCNLLLHIEDPIGTYPSEYHRVIWCPYIPEDDETesDDDDESKLLVLLRGDKAEIWNVD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758   268 ILRSNNSSWPVDATELKEGFITIRGHAaRISEGALSPDGTVLATASHDGYVKFWQIYIEGQDQPRCLHEWQPHNGQPLSC 347
Cdd:pfam16529  161 MIVSEHGSGPLQPAALESGYIEIEEHS-LLVDAAFSPDGTALATASLDGEVKFFQIYLFDNRNPRCLHEWKPHDGKPLSS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758   348 LLFCDNHKKQdPDVPFWRFLITGADQNQELKMWCTVSWTCLQTIRFSPDPFNCGVLPSLKASLDLSAEFLILSDVQRKVL 427
Cdd:pfam16529  240 LFFLDNHKKP-PEVQFWRFAITGADNNSELKLWSCESWTCLQTIRFVPDPPSSLQPPNLKAGLDLSANYLVLSDLDNKVL 318

                          330
                   ....*....|
gi 123912758   428 YVMELLQDQE 437
Cdd:pfam16529  319 YVLQLGQDGE 328
WD40 COG2319
WD40 repeat [General function prediction only];
156-396 3.93e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.86  E-value: 3.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  156 IRVLHLSS-TERSLLKGFTGAVTDLAFAHlDSTLLGCVDEAGNMFIWQLTShsskiqdevivhirRPEDTPLNSNRRLIW 234
Cdd:COG2319   186 VRLWDLATgKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT--------------GKLLRTLTGHSGSVR 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  235 CPFIpedndeSPEDacQTLALLHEDR-AEVWDLDilrsnnsswpvDATELKegfiTIRGHAARISEGALSPDGTVLATAS 313
Cdd:COG2319   251 SVAF------SPDG--RLLASGSADGtVRLWDLA-----------TGELLR----TLTGHSGGVNSVAFSPDGKLLASGS 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  314 HDGYVKFWQIyiegqDQPRCLHEWQPHNGQPLScLLFcdnhkkqDPDVpfwRFLITGADQNQeLKMWCTVSWTCLQTIR- 392
Cdd:COG2319   308 DDGTVRLWDL-----ATGKLLRTLTGHTGAVRS-VAF-------SPDG---KTLASGSDDGT-VRLWDLATGELLRTLTg 370

                         250
                  ....*....|...
gi 123912758  393 ---------FSPD 396
Cdd:COG2319   371 htgavtsvaFSPD 383
WD40 COG2319
WD40 repeat [General function prediction only];
156-396 4.09e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 4.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  156 IRVLHLSSTER-SLLKGFTGAVTDLAFAHlDSTLLGCVDEAGNMFIWQLTSHsskiqdEVIVHIRRPEDTPlnsnRRLIW 234
Cdd:COG2319   102 VRLWDLATGLLlRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATG------KLLRTLTGHSGAV----TSVAF 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  235 cpfipedndeSPEDacQTLALLHEDR-AEVWDLDilrsnnsswpvDATELKegfiTIRGHAARISEGALSPDGTVLATAS 313
Cdd:COG2319   171 ----------SPDG--KLLASGSDDGtVRLWDLA-----------TGKLLR----TLTGHTGAVRSVAFSPDGKLLASGS 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  314 HDGYVKFWQIyiegqDQPRCLHEWQPHNGQPLScLLFcdnhkkqDPDVpfwRFLITGaDQNQELKMWCTVSWTCLQT--- 390
Cdd:COG2319   224 ADGTVRLWDL-----ATGKLLRTLTGHSGSVRS-VAF-------SPDG---RLLASG-SADGTVRLWDLATGELLRTltg 286

                         250
                  ....*....|...
gi 123912758  391 -------IRFSPD 396
Cdd:COG2319   287 hsggvnsVAFSPD 299
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 169-400 7.22e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.58  E-value: 7.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  169 LKGFTGAVTDLAFaHLDSTLL--GCVDeaGNMFIWQLTSHSSKIQDEVivHIRrpedtplnSNRRLIWCPFIP------E 240
Cdd:cd00200     5 LKGHTGGVTCVAF-SPDGKLLatGSGD--GTIKVWDLETGELLRTLKG--HTG--------PVRDVAASADGTylasgsS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  241 DN-----DESPEDACQTLALlHEDraEVWDLDILRSNN----SS-------WPVDATELKegfITIRGHAARISEGALSP 304
Cdd:cd00200    72 DKtirlwDLETGECVRTLTG-HTS--YVSSVAFSPDGRilssSSrdktikvWDVETGKCL---TTLRGHTDWVNSVAFSP 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  305 DGTVLATASHDGYVKFWQIyiegqDQPRCLHEWQPHNGqPLSCLLFCDNHKKqdpdvpfwrfLITGADqNQELKMWCTVS 384
Cdd:cd00200   146 DGTFVASSSQDGTIKLWDL-----RTGKCVATLTGHTG-EVNSVAFSPDGEK----------LLSSSS-DGTIKLWDLST 208

                         250
                  ....*....|....*.
gi 123912758  385 WTCLQTIRFSPDPFNC 400
Cdd:cd00200   209 GKCLGTLRGHENGVNS 224
WD40 COG2319
WD40 repeat [General function prediction only];
136-346 1.02e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 1.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  136 IAVS--NTYLAYAirGANNhsMIRVLHLSS-TERSLLKGFTGAVTDLAFAHlDSTLLGCVDEAGNMFIWQLTSHSskiqd 212
Cdd:COG2319   210 VAFSpdGKLLASG--SADG--TVRLWDLATgKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGE----- 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  213 evIVHIRRPEDTPLNSnrrLIWcpfipedndeSPEDacQTLALLHEDR-AEVWDLDilrsnnsswpvDATELKegfiTIR 291
Cdd:COG2319   280 --LLRTLTGHSGGVNS---VAF----------SPDG--KLLASGSDDGtVRLWDLA-----------TGKLLR----TLT 327

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 123912758  292 GHAARISEGALSPDGTVLATASHDGYVKFWQIyiegqDQPRCLHEWQPHNGQPLS 346
Cdd:COG2319   328 GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL-----ATGELLRTLTGHTGAVTS 377
WD40 COG2319
WD40 repeat [General function prediction only];
156-323 1.49e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 1.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  156 IRVLHLSSTER-SLLKGFTGAVTDLAFAHlDSTLLGCVDEAGNMFIWQLTSHSskiqdevIVHIRRPEDTPLNSnrrLIW 234
Cdd:COG2319   270 VRLWDLATGELlRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGK-------LLRTLTGHTGAVRS---VAF 338

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  235 cpfipedndeSPEDacQTLALLHEDR-AEVWDLDilrsnnsswpvDATELKegfiTIRGHAARISEGALSPDGTVLATAS 313
Cdd:COG2319   339 ----------SPDG--KTLASGSDDGtVRLWDLA-----------TGELLR----TLTGHTGAVTSVAFSPDGRTLASGS 391

                         170
                  ....*....|
gi 123912758  314 HDGYVKFWQI 323
Cdd:COG2319   392 ADGTVRLWDL 401
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 289-321 1.66e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 1.66e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 123912758    289 TIRGHAARISEGALSPDGTVLATASHDGYVKFW 321
Cdd:smart00320    7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 COG2319
WD40 repeat [General function prediction only];
252-396 7.66e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 7.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  252 TLALLHEDRAEVWDLDILRSNNSSWPVDATELKEGFITIRGHAARISEGALSPDGTVLATASHDGYVKFWQIyiegqDQP 331
Cdd:COG2319    36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL-----ATG 110

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 123912758  332 RCLHEWQPHNGQPLSCLLfcdnhkkqDPDVpfwRFLITGADqNQELKMWCTVSWTCLQTIR----------FSPD 396
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAF--------SPDG---KTLASGSA-DGTVRLWDLATGKLLRTLTghsgavtsvaFSPD 173
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 156-322 7.96e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.17  E-value: 7.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  156 IRVLHLSSTE-RSLLKGFTGAVTDLAFAHlDSTLLGCVDEAGNMFIW---------QLTSHSSKIQDeVIVHirrPEDTP 225
Cdd:cd00200   117 IKVWDVETGKcLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWdlrtgkcvaTLTGHTGEVNS-VAFS---PDGEK 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  226 L----NSNRRLIWcpfipeDNDESpedacQTLALLHEDRAEVWDLDILRSNN---SS--------WPVDATELKEgfiTI 290
Cdd:cd00200   192 LlsssSDGTIKLW------DLSTG-----KCLGTLRGHENGVNSVAFSPDGYllaSGsedgtirvWDLRTGECVQ---TL 257

                         170       180       190
                  ....*....|....*....|....*....|..
gi 123912758  291 RGHAARISEGALSPDGTVLATASHDGYVKFWQ 322
Cdd:cd00200   258 SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
289-321 1.96e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.96e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 123912758   289 TIRGHAARISEGALSPDGTVLATASHDGYVKFW 321
Cdd:pfam00400    6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 289-380 2.21e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123912758  289 TIRGHAARISEGALSPDGTVLATASHDGYVKFWQIyiegqDQPRCLHEWQPHNGqPLSCLLFcdnhkkqDPDVPfwrFLI 368
Cdd:cd00200   214 TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL-----RTGECVQTLSGHTN-SVTSLAW-------SPDGK---RLA 277

                          90
                  ....*....|..
gi 123912758  369 TGADQNQeLKMW 380
Cdd:cd00200   278 SGSADGT-IRIW 288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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