AP-3 complex subunit beta is part of the non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
34-590
1.26e-171
Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.
:
Pssm-ID: 396262 [Multi-domain] Cd Length: 523 Bit Score: 513.71 E-value: 1.26e-171
Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of ...
803-947
4.11e-64
Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of the clathrin-adaptor protein complex-3 beta-1 subunit. The AP-3 complex is associated with the Golgi region of the cell as well as with more peripheral structures. The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules.
:
Pssm-ID: 464319 Cd Length: 148 Bit Score: 213.28 E-value: 4.11e-64
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
34-590
1.26e-171
Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.
Pssm-ID: 396262 [Multi-domain] Cd Length: 523 Bit Score: 513.71 E-value: 1.26e-171
Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of ...
803-947
4.11e-64
Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of the clathrin-adaptor protein complex-3 beta-1 subunit. The AP-3 complex is associated with the Golgi region of the cell as well as with more peripheral structures. The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules.
Pssm-ID: 464319 Cd Length: 148 Bit Score: 213.28 E-value: 4.11e-64
Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid ...
107-233
9.87e-03
Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid cohesion protein 2 (Scc2) and its homolog (Scc2 homolog, also called Nipped-B-like protein or NIPBL). Scc2/NIPBL and Scc4 form a complex that is responsible for loading the cohesin protein onto sister chromatids during mitosis and meiosis. Cohesin is a ring-shaped protein complex that encircles the sister chromatids and helps to hold them together until they are ready to be separated during cell division. In addition to its role in chromosome segregation, cohesin also plays important roles in other cellular processes such as transcription, chromosome condensation, and DNA repair.
Pssm-ID: 467937 [Multi-domain] Cd Length: 1197 Bit Score: 39.97 E-value: 9.87e-03
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
34-590
1.26e-171
Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.
Pssm-ID: 396262 [Multi-domain] Cd Length: 523 Bit Score: 513.71 E-value: 1.26e-171
Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of ...
803-947
4.11e-64
Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of the clathrin-adaptor protein complex-3 beta-1 subunit. The AP-3 complex is associated with the Golgi region of the cell as well as with more peripheral structures. The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules.
Pssm-ID: 464319 Cd Length: 148 Bit Score: 213.28 E-value: 4.11e-64
non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of ...
125-246
3.76e-18
non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.
Pssm-ID: 463677 [Multi-domain] Cd Length: 162 Bit Score: 82.89 E-value: 3.76e-18
Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid ...
107-233
9.87e-03
Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid cohesion protein 2 (Scc2) and its homolog (Scc2 homolog, also called Nipped-B-like protein or NIPBL). Scc2/NIPBL and Scc4 form a complex that is responsible for loading the cohesin protein onto sister chromatids during mitosis and meiosis. Cohesin is a ring-shaped protein complex that encircles the sister chromatids and helps to hold them together until they are ready to be separated during cell division. In addition to its role in chromosome segregation, cohesin also plays important roles in other cellular processes such as transcription, chromosome condensation, and DNA repair.
Pssm-ID: 467937 [Multi-domain] Cd Length: 1197 Bit Score: 39.97 E-value: 9.87e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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