Forkhead (FH) domain found in Forkhead box protein O1 (FOXO1); FOXO1, also called Forkhead box protein O1A or Forkhead in rhabdomyosarcoma (FKHR), is a transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. It binds to the insulin response element (IRE) with the consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with the consensus sequence 5'-TT[G/A]TTTAC-3'. The FH domain is a winged helix DNA-binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 151 KSSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEG 230
Cdd:cd20060    1 KSSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEG 80

                         90
                 ....*....|....*....
gi 116241368 231 TGKSSWWMLNPEGGKSGKS 249
Cdd:cd20060   81 TGKSSWWMLNPEGGKSGKS 99

Transactivation domain of FOXO protein family; TAD is a promiscuous binding domain that mediates the association of the transcription factor FOXO with the coactivator CBP/p300. Both this domain and the FOXO-KIX_bd family pfam16675 bind simultaneously the KIX domain of CBP/p300. Coactivator CBP/p300 is recruited by FOXO3 though binding to these two regions. The promiscuity of the TAD is further evidenced by that the finding that they also bind the TAZ1 and TAZ2 domains of CBP/p300.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 116241368  597 KLPSDLD-GMFIERLDCDMESIIRNDLMDGDTLDFNFD 633
Cdd:pfam16676   1 RLPSDLDlDMFQGSLECDVDSIIRNDLMDGDGLDFNFD 38

Forkhead (FH) domain found in Forkhead box protein O1 (FOXO1); FOXO1, also called Forkhead box protein O1A or Forkhead in rhabdomyosarcoma (FKHR), is a transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. It binds to the insulin response element (IRE) with the consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with the consensus sequence 5'-TT[G/A]TTTAC-3'. The FH domain is a winged helix DNA-binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 151 KSSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEG 230
Cdd:cd20060    1 KSSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEG 80

                         90
                 ....*....|....*....
gi 116241368 231 TGKSSWWMLNPEGGKSGKS 249
Cdd:cd20060   81 TGKSSWWMLNPEGGKSGKS 99

Forkhead domain;

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368  162 NLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKdkgdsNSSAGWKNSIRHNLSLHSKFIRV--QNEGTGKSSWWML 239
Cdd:pfam00250   3 PYSYAALIAMAILSSPEKKLTLSEIYEWISENFPYYR-----TADKGWQNSIRHNLSLNKCFVKVprPKDEPGKGSYWTI 77

                  ...
gi 116241368  240 NPE 242
Cdd:pfam00250  78 DPE 80

Transactivation domain of FOXO protein family; TAD is a promiscuous binding domain that mediates the association of the transcription factor FOXO with the coactivator CBP/p300. Both this domain and the FOXO-KIX_bd family pfam16675 bind simultaneously the KIX domain of CBP/p300. Coactivator CBP/p300 is recruited by FOXO3 though binding to these two regions. The promiscuity of the TAD is further evidenced by that the finding that they also bind the TAZ1 and TAZ2 domains of CBP/p300.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 116241368  597 KLPSDLD-GMFIERLDCDMESIIRNDLMDGDTLDFNFD 633
Cdd:pfam16676   1 RLPSDLDlDMFQGSLECDVDSIIRNDLMDGDGLDFNFD 38

Forkhead (FH) domain found in Forkhead box protein O1 (FOXO1); FOXO1, also called Forkhead box protein O1A or Forkhead in rhabdomyosarcoma (FKHR), is a transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. It binds to the insulin response element (IRE) with the consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with the consensus sequence 5'-TT[G/A]TTTAC-3'. The FH domain is a winged helix DNA-binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 151 KSSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEG 230
Cdd:cd20060    1 KSSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEG 80

                         90
                 ....*....|....*....
gi 116241368 231 TGKSSWWMLNPEGGKSGKS 249
Cdd:cd20060   81 TGKSSWWMLNPEGGKSGKS 99

Forkhead (FH) domain found in Forkhead box protein O4 (FOXO4) and similar proteins; FOXO4, also called Fork head domain transcription factor AFX1, is a transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. The FH domain is a winged helix DNA-binding domain. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 157 RNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSW 236
Cdd:cd20062    1 RNAWGNQSYAELISQAIESSPEKRLTLAQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHNEATGKSSW 80

                 ....*.
gi 116241368 237 WMLNPE 242
Cdd:cd20062   81 WMLNPE 86

Forkhead (FH) domain found in the Forkhead box protein O (FOXO) subfamily; The FOXO subfamily includes several winged helix transcription factors: FOXO1, FOXO3, FOXO4 and FOXO6. FOXO transcription factors are involved in the regulation of longevity phenomenon via insulin and insulin-like growth factor signaling. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members. FOXO1, also called Forkhead box protein O1A or Forkhead in rhabdomyosarcoma (FKHR), is a transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. FOXO3, also called AF6q21 protein or Forkhead in rhabdomyosarcoma-like 1 (FKHRL1), is a transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. It recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. FOXO4, also called Fork head domain transcription factor AFX1, is a transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO6 acts as a transcriptional activator that may play an important role on tumor invasion, metastasis, and prognosis. The FH domain is a winged helix DNA-binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 161 GNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLN 240
Cdd:cd20032    1 GNMSYADLITKAIESSPDKRLTLQQIYDWMVRNVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFVRVQNEGTGKSSWWTLN 80

FORKHEAD; FORKHEAD, also known as a "winged helix"

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368   160 WGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDsnssaGWKNSIRHNLSLHSKFIRVQNEGT--GKSSWW 237
Cdd:smart00339   1 KPPYSYIALIAMAILSSPDKRLTLSEIYKWIEDNFPYYRENRA-----GWQNSIRHNLSLNDCFVKVPREGDrpGKGSYW 75

                   ....*
gi 116241368   238 MLNPE 242
Cdd:smart00339  76 TLDPA 80

Forkhead (FH) domain found in Forkhead box protein Q2 (FOXQ2) and similar proteins; FOXQ2 is the neurogenic ectoderm specification transcription factor that controls aboral development in cnidarians and anterior identity in bilaterians. It plays essential roles in epidermal development and central brain patterning. The foxQ2 gene is absent in placental mammals. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 162 NLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGdsnssAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNP 241
Cdd:cd20035    3 SHSYVALIAKAILSSPEKKLVLSDIYQYIEENYPYFKSRG-----SSWKNSVRHNLSLNECFVKAGRAENGKGNYWTIHP 77

                         90
                 ....*....|....*.
gi 116241368 242 EGGKS---GKSPRRRA 254
Cdd:cd20035   78 ACLEDfekGDFRRRRA 93

Forkhead (FH) domain found in Forkhead box proteins, FOXJ2, FOXJ3 and similar proteins; The FOXJ2-like subfamily includes two winged helix transcription factors, FOXJ2 and FOXJ3. FOXJ2, also called Forkhead homologous X (FHX), plays an important role in tumorigenesis, progression, and metastasis of certain cancers. It acts as a transcriptional activator that can bind to two different type of DNA binding sites. FOXJ3 is a transcription factor which regulates sperm function. It transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116241368 163 LSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDkgdsnSSAGWKNSIRHNLSLHSKFIRV--QNEGTGKSSWWML 239
Cdd:cd20024    4 YSYATLITFAINSSPKKKMTLSEIYTWICENFPYYRE-----AGTGWKNSIRHNLSLNKCFKKVprSKDDPGKGSYWTL 77

Forkhead (FH) domain found in the Forkhead box protein K (FOXK) subfamily; The FOXK subfamily includes two winged helix transcription factors, FOXK1 and FOXK2. FOXK1, also called myocyte nuclear factor (MNF), acts as a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin genes. It positively regulates Wnt/beta-catenin signaling by translocating dishevelled (DVL) proteins into the nucleus. It also reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression. In addition, FOXK1 plays important roles in multiple human cancers. FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both, positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFK--DKgdsnssaGWKNSIRHNLSLHSKFIRVQ--NEGTGKSSWWML 239
Cdd:cd20026    5 SYAQLIVQAISSAPDKQLTLSGIYAYITKNYPYYRtaDK-------GWQNSIRHNLSLNRYFIKVPrsQEEPGKGSFWRI 77

                 .
gi 116241368 240 N 240
Cdd:cd20026   78 D 78

Forkhead (FH) domain found in the Forkhead box protein M (FOXM) subfamily; The FOXM subfamily includes a winged helix transcription factor, FOXM1, which is also called Forkhead-related protein FKHL16, Hepatocyte nuclear factor 3 Forkhead homolog 11 (HFH-11), HNF-3/fork-head homolog 11, M-phase phosphoprotein 2, MPM-2 reactive phosphoprotein 2, transcription factor Trident, or Winged-helix factor from INS-1 cells. FOXM1 acts as a transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. It plays a role in the control of cell proliferation. It is also involved in DNA break repair, participating in the DNA damage checkpoint response. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116241368 164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKdkgdSNSSAGWKNSIRHNLSLHSKFIRvQNEGTGKSSWWMLNP 241
Cdd:cd20029    5 SYMALIQFAINSTEDKRMTLKEIYTWIEDHFPYFK----HTAKPGWKNSIRHNLSLHDIFVR-ETSANGKGSFWTLRP 77

Forkhead (FH) domain found in Forkhead box protein J2 (FOXJ2) and similar proteins; FOXJ2, also called Fork head homologous X (FHX), plays an important role in tumorigenesis, progression, and metastasis of certain cancers. It acts as a transcriptional activator that can bind to two different type of DNA binding sites. It is specifically expressed in meiotic spermatocytes in adult mouse testes and appears to promote meiotic progression during spermatogenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116241368 164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKdkgdsNSSAGWKNSIRHNLSLHSKFIRV--QNEGTGKSSWWMLN 240
Cdd:cd20051    6 SYATLITYAINSSPAKKMTLSEIYRWICDNFPYYR-----NAGVGWKNSIRHNLSLNKCFRKVprPRDDPGKGSYWMID 79

Forkhead (FH) domain found in Forkhead box protein Q1 (FOXQ1) and similar proteins; FOXQ1, also called HNF-3/Forkhead-like protein 1 (HFH-1), or hepatocyte nuclear factor 3 Forkhead homolog 1, plays a role in hair follicle differentiation. It has also been reported to promote epithelial differentiation, inhibit smooth muscle differentiation, activate T cells and autoimmunity, and control mucin gene expression and granule content in stomach surface mucous cells. FOXQ1 is significantly associated with the pathogenesis of various tumor types including gastric, breast, colorectal, pancreatic, bladder and ovarian cancer, and glioma. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 163 LSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKdkgdsNSSAGWKNSIRHNLSLHSKFIRVQNEGT---GKSSWWML 239
Cdd:cd20034    4 YSYIALIAMAIRDSPSGRLTLAEINEYLMKKFPFFR-----GSYTGWRNSVRHNLSLNDCFVKVLRDPSrpwGKDNYWTI 78

                 .
gi 116241368 240 N 240
Cdd:cd20034   79 N 79

Forkhead (FH) domain found in the Forkhead box protein P (FOXP) subfamily; The FOXP subfamily includes four winged helix transcription factors, FOXP1-4. They are involved in the development of the central nervous system. Mutations in FOXP1, also called Mac-1-regulated Forkhead (MFH), leads to developmental delay, intellectual disability, autism spectrum disorder, speech delay, and dysmorphic features. FOXP2, also called CAG repeat protein 44 or Trinucleotide repeat-containing gene 10 protein, is a transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. It may also play a role in developing neural, gastrointestinal and cardiovascular tissues. FOXP3, also called Scurfin, is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). FOXP4, also called Forkhead-related protein-like A, is a transcriptional repressor that represses lung-specific expression. It is necessary for normal T cell cytokine recall responses to antigen following pathogenic infection. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 116241368 164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKgdsnsSAGWKNSIRHNLSLHSKFIRVQNegtGKSSWWMLN 240
Cdd:cd20033    5 TYASLIRQAILESPNKQLTLNEIYNWFQKTFAYFRRN-----AATWKNAVRHNLSLHKCFVRVEN---VKGAVWTVD 73

Forkhead (FH) domain found in the Forkhead box protein E (FOXE) subfamily; The FOXE subfamily includes two winged helix transcription factors, FOXE1 (also known as FOXE2) and FOXE3. FOXE1, also called Forkhead-related protein FKHL15, HFKH4, HNF-3/fork head-like protein 5 (HFKL5), or thyroid transcription factor 2 (TTF-2), is a transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. FOXE3, also called Forkhead-related protein FKHL12 or Forkhead-related transcription factor 8 (FREAC-8), is a transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis, and the cell cycle. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDkgdsnSSAGWKNSIRHNLSLHSKFIRVQNE--GTGKSSWWMLNP 241
Cdd:cd20019    5 SYIALIAMAIANSPERKLTLGGIYKFIMERFPFYRD-----NSKKWQNSIRHNLTLNDCFVKIPREpgRPGKGNYWTLDP 79

                         90
                 ....*....|....*
gi 116241368 242 EGG---KSGKSPRRR 253
Cdd:cd20019   80 AAEdmfDNGSFLRRR 94

Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3); FOXN3, also called checkpoint suppressor 1 (CHES1), acts as a transcriptional repressor that may be involved in DNA damage-inducible cell cycle arrests (checkpoints). It displays transcriptional inhibitory activity, and is involved in cell cycle regulation and tumorigenesis. Alterations in FOXN3 are found in of a variety of cancers including melanoma, osteosarcoma, and hepatocellular carcinoma. FOXN3 also regulates hepatic glucose utilization/metabolism by regulating gluconeogenic substrate selection. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKdkgdsNSSAGWKNSIRHNLSLHSKFIRVQNE---GTGKSSWWMLN 240
Cdd:cd20059    5 SFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFA-----NAPTGWKNSVRHNLSLNKCFKKVDKEkgqSIGKGSLWCID 79

                 ..
gi 116241368 241 PE 242
Cdd:cd20059   80 PE 81

Forkhead (FH) domain found in Forkhead box protein P1 (FOXP1); FOXP1, also called Mac-1-regulated Forkhead (MFH), is a transcription factor that is widely expressed and has a broad range of functions. It has been shown to have a role in cardiac, lung, and lymphocyte development. Deregulation of FOXP1 is an important contributor to the pathogenesis of diffuse large B-cell lymphoma (DLBCL), suggesting it may function as an oncogene. Loss of FOXP1 expression in breast cancer is associated with a worse outcome, suggesting that FOXP1 may function as a tumor suppressor in some tissues. Haploinsufficiency of the FOXP1 gene leads to a neurodevelopmental disorder termed FOXP1 syndrome, characterized by developmental delay, intellectual disability, autism spectrum disorder, speech delay, and dysmorphic features. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 116241368 163 LSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKdkgdsNSSAGWKNSIRHNLSLHSKFIRVQN 228
Cdd:cd20064    7 FTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFR-----RNAATWKNAVRHNLSLHKCFVRVEN 67

Forkhead (FH) domain found in the Forkhead box protein F (FOXF) subfamily; The FOXF subfamily includes two winged helix transcription factors, FOXF1 and FOXF2, both of which are probable transcription activators for a number of lung-specific genes. FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins (ACD/MPV) suggest its involvement in ACD/MPV and lung organogenesis. FOXF2 is involved in programming organogenesis and regulating epithelial-to-mesenchymal transition (EMT) and cell proliferation. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 163 LSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKdkgdsNSSAGWKNSIRHNLSLHSKFIRV-QNEG-TGKSSWWMLN 240
Cdd:cd20020    3 YSYIALIVMAIQASPTKRLTLSEIYQFLQQRFPFFR-----GPYQGWKNSVRHNLSLNECFIKLpKGLGrPGKGHYWTID 77

                 .
gi 116241368 241 P 241
Cdd:cd20020   78 P 78

Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2); FOXP2, also called CAG repeat protein 44, or Trinucleotide repeat-containing gene 10 protein, is a transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. It may also play a role in developing neural, gastrointestinal, and cardiovascular tissues. An arginine-to-histidine missense mutation (R553H) in the FOXP2 Forkhead domain has been linked to a severe speech and language disorder. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 116241368 164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKdkgdsNSSAGWKNSIRHNLSLHSKFIRVQN 228
Cdd:cd20065    6 TYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFR-----RNAATWKNAVRHNLSLHKCFVRVEN 65

Forkhead (FH) domain found in Forkhead box protein K1 (FOXK1) and similar proteins; FOXK1, also called myocyte nuclear factor (MNF), acts as a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin genes. It positively regulates Wnt/beta-catenin signaling by translocating dishevelled (DVL) proteins into the nucleus. It also reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression. In addition, FOXK1 plays important roles in multiple human cancers. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 163 LSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKdkgdsNSSAGWKNSIRHNLSLHSKFIRV--QNEGTGKSSWWMLN 240
Cdd:cd20054    6 YSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPYYR-----TADKGWQNSIRHNLSLNRYFIKVprSQEEPGKGSFWRID 80

                 .
gi 116241368 241 P 241
Cdd:cd20054   81 P 81

Forkhead (FH) domain found in Forkhead box protein C2 (FOXC2) and similar proteins; FOXC2, also called Forkhead-related protein FKHL14, Mesenchyme fork head protein 1 (MFH-1 protein), or transcription factor FKH-14, acts as a transcriptional activator that might be involved in the formation of special mesenchymal tissues. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDkgdsnSSAGWKNSIRHNLSLHSKFIRV--QNEGTGKSSWWMLNP 241
Cdd:cd20045    7 SYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRE-----NKQGWQNSIRHNLSLNECFVKVprDDKKPGKGSYWTLDP 81

                 .
gi 116241368 242 E 242
Cdd:cd20045   82 D 82

Forkhead (FH) domain found in Forkhead box protein S1 (FOXS1); FOXS1, also called Forkhead-like 18 protein or Forkhead-related transcription factor 10 (FREAC-10), is a transcriptional repressor that suppresses transcription from the FASLG, FOXO3, and FOXO4 promoters. It may have a role in the organization of the testicular vasculature. It has also been implicated in energy turnover, motor function, and body weight. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDkgdsnSSAGWKNSIRHNLSLHSKFIRV--QNEGTGKSSWWMLNP 241
Cdd:cd20037    6 SYIALIAMAIQSSPGQRATLSGIYRYIMGRFAFYRH-----NRPGWQNSIRHNLSLNECFVKVprDDRKPGKGSYWTLDP 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 116241368 242 EggksgksprrrAASMDNNSKFAKSRSRAAK 272
Cdd:cd20037   81 D-----------CHDMFEHGSFLRRRRRFTR 100

Forkhead (FH) domain found in Forkhead box protein C1 (FOXC1) and similar proteins; FOXC1, also called Forkhead-related protein FKHL7, or Forkhead-related transcription factor 3 (FREAC-3), is a DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as the development of the eyes, bones, cardiovascular system, kidneys, and skin. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDkgdsnSSAGWKNSIRHNLSLHSKFIRV--QNEGTGKSSWWMLNP 241
Cdd:cd20044   10 SYIALITMAIQNAPDKKITLNGIYQFIMERFPFYRD-----NKQGWQNSIRHNLSLNECFVKVprDDKKPGKGSYWTLDP 84

                 .
gi 116241368 242 E 242
Cdd:cd20044   85 D 85

Forkhead (FH) domain found in Forkhead box protein D4 (FOXD4) and similar proteins; FOXD4, also called Forkhead-related protein FKHL9, Forkhead-related transcription factor 5 (FREAC-5), or myeloid factor-alpha, is essential for establishing neural cell fate and for neuronal differentiation. The family also includes Forkhead box protein D4-like proteins, FOXD4L1-6. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKgdsnsSAGWKNSIRHNLSLHSKFIRVQNE--GTGKSSWWMLNP 241
Cdd:cd20048    5 SYIALITMAILQSPHKRLTLSGICAFISGRFPYYRRK-----FPAWQNSIRHNLSLNDCFVKIPREpgHPGKGNYWSLDP 79

                         90       100
                 ....*....|....*....|....*...
gi 116241368 242 EggksgksprrrAASMDNNSKFAKSRSR 269
Cdd:cd20048   80 A-----------SQDMFDNGSFLRRRKR 96

Forkhead (FH) domain found in the Forkhead box protein R (FOXR) subfamily; The FOXR subfamily includes two winged helix transcription factors, FOXR1-2. FOXR1, also called Forkhead box protein N5 (FOXN5), is required for proper cell division and survival possibly via the p21 and mTOR pathways. FOXR2, also called Forkhead box protein N6 (FOXN6), is an important player in a wide range of cellular processes such as proliferation, migration, differentiation, and apoptosis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 163 LSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDkgdsnSSAGWKNSIRHNLSLHSKF----IRVQNEGTGKSSWWM 238
Cdd:cd20036    6 LSYPNLIALALRNSETGSLNVQEIYDFIRFHFPFFRT-----APDGWKNSVRHNLSFSDSFekvpTSVSGYGGRRSCLWK 80

                 ....*
gi 116241368 239 LNPEG 243
Cdd:cd20036   81 LTPEG 85

Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2); FOXN2, also called human T-cell leukemia virus enhancer factor (HTLF), is a potential tumor suppressor that can facilitate replication fork reversal. It acts as a transcription factor that binds to the purine-rich region in human T-cell leukemia virus long terminal repeat (HTLV-I LTR). It may be a potential therapeutic and radiosensitization target for lung cancer. FOXN2 has also been found to be down-regulated in breast cancer, where it regulates migration, invasion, and epithelial-mesenchymal transition. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFkdkgdSNSSAGWKNSIRHNLSLHSKFIRVQ---NEGTGKSSWWMLN 240
Cdd:cd20058    6 SFSLLIYMAIEHSPNKCLPVKEIYSWILEHFPYF-----STAPTGWKNSVRHNLSLNKCFRKVErshGKVNGKGSLWCVD 80

                 ..
gi 116241368 241 PE 242
Cdd:cd20058   81 PE 82

Forkhead (FH) domain found in Forkhead box protein A3 (FOXA3) and similar proteins; FOXA3, also called hepatocyte nuclear factor 3-gamma (HNF-3-gamma or HNF-3G), fork head-related protein FKH H3, or transcription factor 3G (TCF-3G), acts as an essential transcriptional regulator engaged in adipogenesis and energy metabolism. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDkgdsnSSAGWKNSIRHNLSLHSKFIRVQN--EGTGKSSWWMLNP 241
Cdd:cd20040    7 SYISLITMAIQQAPSKMLTLNEIYQWIMDLFPYYRE-----NQQRWQNSIRHSLSFNDCFVKVARspDKPGKGSYWALHP 81

                 ...
gi 116241368 242 EGG 244
Cdd:cd20040   82 NSG 84

Forkhead (FH) domain found in the Forkhead box protein B (FOXB) subfamily; The FOXB subfamily includes two winged helix transcription factors, FOXB1 (also called transcription factor FKH-5) and FOXB2 (also called transcription factor FKH-4). FOXB1 controls development of mammary glands and regions of the central nervous system (CNS) that regulate the milk-ejection reflex. It is essential for access of mammillothalamic axons to the thalamus. FOXB2 may act as a tumor suppressor; it has been found to inhibit the malignant characteristics of the pancreatic cancer cell line Panc-1 in vitro. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDkgdsnSSAGWKNSIRHNLSLHSKFIRVQNEGT--GKSSWWMLNP 241
Cdd:cd20016    5 SYISLTAMAIQSSPEKMLPLSDIYKFIMDRFPYYRK-----NTQRWQNSLRHNLSFNDCFIKIPRRPDrpGKGSYWALHP 79

Forkhead (FH) domain found in the Forkhead box protein D (FOXD) subfamily; The FOXD subfamily includes four winged helix transcription factors, FOXD1-4. FOXD1, also called Forkhead-related protein FKHL8 or Forkhead-related transcription factor 4 (FREAC-4), is involved in transcriptional activation of Placental Growth Factor (PGF) and the complement component (C3) genes. It plays an important role in early embryonic development and organogenesis, and functions as an oncogene in several cancers. FOXD2, also called Forkhead-related protein FKHL17 or Forkhead-related transcription factor 9 (FREAC-9), is a probable transcription factor involved in embryogenesis and somatogenesis. FOXD3, also called HNF3/FH transcription factor genesis, acts as a transcriptional repressor that binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3'. It also acts as a transcriptional activator. It promotes development of neural crest cells from neural tube progenitors and restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. FOXD3 is required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. FOXD4, also called Forkhead-related protein FKHL9 or Forkhead-related transcription factor 5 (FREAC-5), is essential for establishing neural cell fate and for neuronal differentiation. The family also includes Forkhead box protein D4-like proteins, FOXD4L1-6. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116241368 164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKgdsnsSAGWKNSIRHNLSLHSKFIRVQNE--GTGKSSWWMLN 240
Cdd:cd20018    5 SYIALITMAILQSPQKKLTLSGICEFIMNRFPYYREK-----FPAWQNSIRHNLSLNDCFVKIPREpgNPGKGNYWTLD 78

Forkhead (FH) domain found in Forkhead box protein B2 (FOXB2) and similar proteins; FOXB2, also called transcription factor FKH-4, may act as a transcription factor. It may also act as a tumor suppressor; it has been found to inhibit the malignant characteristics of the pancreatic cancer cell line Panc-1 in vitro. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 149 PRKSSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDkgdsnSSAGWKNSIRHNLSLHSKFIRV-- 226
Cdd:cd20043    2 PRPGKNSYSDQKPPYSYISLTAMAIQSSQEKMLPLSDIYKFIMDRFPYYRE-----NTQRWQNSLRHNLSFNDCFIKIpr 76

                         90       100       110
                 ....*....|....*....|....*....|
gi 116241368 227 QNEGTGKSSWWMLNPEGG---KSGKSPRRR 253
Cdd:cd20043   77 RPDQPGKGSFWALHPDCGdmfENGSFLRRR 106

Forkhead (FH) domain found in Forkhead box protein B1 (FOXB1) and similar proteins; FOXB1, also called transcription factor FKH-5, is a winged helix transcription factor that controls development of mammary glands and regions of the central nervous system (CNS) that regulate the milk-ejection reflex. It is essential for access of mammillothalamic axons to the thalamus. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDkgdsnSSAGWKNSIRHNLSLHSKFIRV--QNEGTGKSSWWMLNP 241
Cdd:cd20042   10 SYISLTAMAIQSSPEKMLPLSEIYKFIMDRFPYYRE-----NTQRWQNSLRHNLSFNDCFIKIprRPDQPGKGSFWALHP 84

                 ...
gi 116241368 242 EGG 244
Cdd:cd20042   85 SCG 87

Forkhead (FH) domain found in Forkhead box protein N1 (FOXN1); FOXN1, also called winged helix transcription factor nude, acts as a transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs), both in the prenatal and postnatal thymus. It is also an important factor in controlling the skin wound healing process, as it actively participates in re-epithelialization and is responsible for scar formation. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDsnssaGWKNSIRHNLSLHSKFIRVQNE---GTGKSSWWMLN 240
Cdd:cd20056    6 SYSILIFMALKNSKTGSLPVSEIYNFMTEHFPYFKTAPD-----GWKNSVRHNLSLNKCFEKVENKsgsSSRKGCLWALN 80

                 .
gi 116241368 241 P 241
Cdd:cd20056   81 P 81

Forkhead (FH) domain found in Forkhead box protein N4 (FOXN4); FOXN4 acts as a transcription factor essential for neural and some non-neural tissue development, such as retina and lung, respectively. During development of the central nervous system, FOXN4 is required in specifying the amacrine and horizontal cell fates from multipotent retinal progenitors, while suppressing alternative photoreceptor cell fates. In non-neural tissues, it plays an essential role in specifying the atrioventricular canal and is indirectly required for patterning the distal airway during lung development. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241368 164 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDsnssaGWKNSIRHNLSLHSKFIRVQNEGTG---KSSWWMLN 240
Cdd:cd20057   10 SYSCLIAMALKNSKTGSLPVSEIYSFMKEHFPYFKTAPD-----GWKNSVRHNLSLNKCFEKVENKMSGssrKGCLWALN 84

                 .
gi 116241368 241 P 241
Cdd:cd20057   85 P 85