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Conserved domains on  [gi|302393805|sp|Q0WV90|]
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RecName: Full=Topless-related protein 1; AltName: Full=Protein MODIFIER OF SNC1 10

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 359-667 7.71e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 143.63  E-value: 7.71e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  359 MSMDFHPIKQTLLlvgtnvgdiglweVGSRerlvQKTFKVWDLSKCSMPLQaalVKEPVVSVNRVIWSPDGSLFGVAYSR 438
Cdd:cd00200    13 TCVAFSPDGKLLA-------------TGSG----DGTIKVWDLETGELLRT---LKGHTGPVRDVAASADGTYLASGSSD 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  439 HIVQLYSYHGGEDMRqhlEIDAHVGGVNDIAFStPNKQLcVTTCGDDKTIKVWDAATGVKRYTFEGHEAPVYSICPHykE 518
Cdd:cd00200    73 KTIRLWDLETGECVR---TLTGHTSYVSSVAFS-PDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS--P 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  519 NIQFIFSTALDGKIKAWLYDNMGSRVDYEAPGRWCTTMAYSADGTRLFSCGTskDGESFIveWNESEGAVKRTYQGfHKR 598
Cdd:cd00200   146 DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS--DGTIKL--WDLSTGKCLGTLRG-HEN 220

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  599 SLGVVQFDTTKNRYLAAGDDFSIKFWDMDTIQLLTAIDA-DGGLQAsprIRFNKEGSLLAVSANDNMIKV 667
Cdd:cd00200   221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTS---LAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
823-1035 3.22e-16

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 3.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  823 PEEAVPCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVK 901
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLL 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  902 SKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDGWEKQksKVLQIPQGRSTSslsdtrVQFHQDQVHFLVVHETQ- 980
Cdd:COG2319   240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL--RTLTGHSGGVNS------VAFSPDGKLLASGSDDGt 311

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 302393805  981 LAIYETTKLECMKQWpvRESAAPITHATFSCDSQLIYTSFMDATICVFSSANLRL 1035
Cdd:COG2319   312 VRLWDLATGKLLRTL--TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 34-92 1.82e-15

C-terminal to LisH motif; Alpha-helical motif of unknown function.


:

Pssm-ID: 128914  Cd Length: 58  Bit Score: 71.45  E-value: 1.82e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 302393805     34 FFFNMKYFEDEVHNGNWDEVEKYLSGFTKVDDNRYSmKIFFEIRKQKYLEALDRHDRPK 92
Cdd:smart00668    1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNS-KLEFELRKQKFLELVRQGKLEE 58
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 4-34 9.24e-06

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


:

Pssm-ID: 128913  Cd Length: 34  Bit Score: 43.19  E-value: 9.24e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 302393805      4 LSRELVFLILQFLDEEKFKETVHKLEQESGF 34
Cdd:smart00667    2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
PTZ00249 super family cl25531
variable surface protein Vir28; Provisional
 190-314 1.00e-04

variable surface protein Vir28; Provisional


The actual alignment was detected with superfamily member PTZ00249:

Pssm-ID: 140276 [Multi-domain]  Cd Length: 516  Bit Score: 46.18  E-value: 1.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  190 RPNPDIKTLFVDHSCRLPNDARAPSPVNnpllGSLPKAEGFPPLGAHGP------------FQPTPSPVPTPLAGWMSSP 257
Cdd:PTZ00249  238 RPPKHISFSSPHAHGRPPVETRPPNPVS----VSSPQAHGRHPGETHTPplvtvpsskahdRNPVQTPTPTSVSGYSSQA 313

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 302393805  258 SSVPHPAVSGGPIALGAPSIQAALKHPRTPPSNSAVDYPSGDSDHVSKRTRPMGISD 314
Cdd:PTZ00249  314 KGLEKQAGGESERTSSVPSEQFPLPLPVLLPLGQSGPLESSESEETDEYAGPKGLPE 370
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 359-667 7.71e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 143.63  E-value: 7.71e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  359 MSMDFHPIKQTLLlvgtnvgdiglweVGSRerlvQKTFKVWDLSKCSMPLQaalVKEPVVSVNRVIWSPDGSLFGVAYSR 438
Cdd:cd00200    13 TCVAFSPDGKLLA-------------TGSG----DGTIKVWDLETGELLRT---LKGHTGPVRDVAASADGTYLASGSSD 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  439 HIVQLYSYHGGEDMRqhlEIDAHVGGVNDIAFStPNKQLcVTTCGDDKTIKVWDAATGVKRYTFEGHEAPVYSICPHykE 518
Cdd:cd00200    73 KTIRLWDLETGECVR---TLTGHTSYVSSVAFS-PDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS--P 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  519 NIQFIFSTALDGKIKAWLYDNMGSRVDYEAPGRWCTTMAYSADGTRLFSCGTskDGESFIveWNESEGAVKRTYQGfHKR 598
Cdd:cd00200   146 DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS--DGTIKL--WDLSTGKCLGTLRG-HEN 220

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  599 SLGVVQFDTTKNRYLAAGDDFSIKFWDMDTIQLLTAIDA-DGGLQAsprIRFNKEGSLLAVSANDNMIKV 667
Cdd:cd00200   221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTS---LAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
393-679 1.21e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.65  E-value: 1.21e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  393 QKTFKVWDLSKcsmPLQAALVKEPVVSVNRVIWSPDGSLFGVAYSRHIVQLYSYHGGEDMRqhlEIDAHVGGVNDIAFSt 472
Cdd:COG2319    99 DGTVRLWDLAT---GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR---TLTGHSGAVTSVAFS- 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  473 PNKQLcVTTCGDDKTIKVWDAATGVKRYTFEGHEAPVYSIC--PhykeNIQFIFSTALDGKIKAWLYDNMGSRVDYEAPG 550
Cdd:COG2319   172 PDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAfsP----DGKLLASGSADGTVRLWDLATGKLLRTLTGHS 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  551 RWCTTMAYSADGTRLFSCgtSKDGESFIveWNESEGAVKRTYQGfHKRSLGVVQFdTTKNRYLA-AGDDFSIKFWDMDTI 629
Cdd:COG2319   247 GSVRSVAFSPDGRLLASG--SADGTVRL--WDLATGELLRTLTG-HSGGVNSVAF-SPDGKLLAsGSDDGTVRLWDLATG 320

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 302393805  630 QLLTAIDADGGLQASprIRFNKEGSLLAVSANDNMIKVMaNSDGLRLLHT 679
Cdd:COG2319   321 KLLRTLTGHTGAVRS--VAFSPDGKTLASGSDDGTVRLW-DLATGELLRT 367
WD40 COG2319
WD40 repeat [General function prediction only];
823-1035 3.22e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 3.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  823 PEEAVPCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVK 901
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLL 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  902 SKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDGWEKQksKVLQIPQGRSTSslsdtrVQFHQDQVHFLVVHETQ- 980
Cdd:COG2319   240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL--RTLTGHSGGVNS------VAFSPDGKLLASGSDDGt 311

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 302393805  981 LAIYETTKLECMKQWpvRESAAPITHATFSCDSQLIYTSFMDATICVFSSANLRL 1035
Cdd:COG2319   312 VRLWDLATGKLLRTL--TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 827-1082 8.13e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.30  E-value: 8.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  827 VPCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVKSKLK 905
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGdGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGECVRTLT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  906 GHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDgwEKQKSKVLQ-----------IPQGR--STSSLSDT-RV------- 964
Cdd:cd00200    91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE--TGKCLTTLRghtdwvnsvafSPDGTfvASSSQDGTiKLwdlrtgk 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  965 -----QFHQDQVHFLVVHET-----------QLAIYETTKLECMKQwpVRESAAPITHATFSCDSQLIYTSFMDATICVF 1028
Cdd:cd00200   169 cvatlTGHTGEVNSVAFSPDgekllssssdgTIKLWDLSTGKCLGT--LRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 302393805 1029 SSANLRLRcrvnpsaylpASLSNSNVHPLVIAAHPqESNMFAVGLSDGGVHIFE 1082
Cdd:cd00200   247 DLRTGECV----------QTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 34-92 1.82e-15

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 71.45  E-value: 1.82e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 302393805     34 FFFNMKYFEDEVHNGNWDEVEKYLSGFTKVDDNRYSmKIFFEIRKQKYLEALDRHDRPK 92
Cdd:smart00668    1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNS-KLEFELRKQKFLELVRQGKLEE 58
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 4-34 9.24e-06

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 43.19  E-value: 9.24e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 302393805      4 LSRELVFLILQFLDEEKFKETVHKLEQESGF 34
Cdd:smart00667    2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 899-936 2.52e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 2.52e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 302393805    899 EVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWN 936
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 451-492 3.13e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 3.13e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 302393805    451 DMRQHLEIDAHVGGVNDIAFStPNKQLCVTtCGDDKTIKVWD 492
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFS-PDGKYLAS-GSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
457-492 9.92e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 9.92e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 302393805   457 EIDAHVGGVNDIAFStPNKQLCVTtCGDDKTIKVWD 492
Cdd:pfam00400    6 TLEGHTGSVTSLAFS-PDGKLLAS-GSDDGTVKVWD 39
PTZ00249 PTZ00249
variable surface protein Vir28; Provisional
 190-314 1.00e-04

variable surface protein Vir28; Provisional


Pssm-ID: 140276 [Multi-domain]  Cd Length: 516  Bit Score: 46.18  E-value: 1.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  190 RPNPDIKTLFVDHSCRLPNDARAPSPVNnpllGSLPKAEGFPPLGAHGP------------FQPTPSPVPTPLAGWMSSP 257
Cdd:PTZ00249  238 RPPKHISFSSPHAHGRPPVETRPPNPVS----VSSPQAHGRHPGETHTPplvtvpsskahdRNPVQTPTPTSVSGYSSQA 313

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 302393805  258 SSVPHPAVSGGPIALGAPSIQAALKHPRTPPSNSAVDYPSGDSDHVSKRTRPMGISD 314
Cdd:PTZ00249  314 KGLEKQAGGESERTSSVPSEQFPLPLPVLLPLGQSGPLESSESEETDEYAGPKGLPE 370
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 5-33 2.53e-04

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 39.30  E-value: 2.53e-04
                           10        20
                   ....*....|....*....|....*....
gi 302393805     5 SRELVFLILQFLDEEKFKETVHKLEQESG 33
Cdd:pfam17814    1 SQDVVRLILQFLKENGLHRTLQALQTESG 29
PTZ00420 PTZ00420
coronin; Provisional
 871-959 2.64e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 2.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  871 LAFHPQDNNIIAIGMDDSTIQIYNVR-----VDEVKSK---LKGHSKRITGLAFsNVLN--VLVSSGADAQLCVWNTdgw 940
Cdd:PTZ00420   80 LQFNPCFSEILASGSEDLTIRVWEIPhndesVKEIKDPqciLKGHKKKISIIDW-NPMNyyIMCSSGFDSFVNIWDI--- 155

                          90
                  ....*....|....*....
gi 302393805  941 EKQKsKVLQIPQGRSTSSL 959
Cdd:PTZ00420  156 ENEK-RAFQINMPKKLSSL 173
WD40 pfam00400
WD domain, G-beta repeat;
899-936 2.98e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.98e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 302393805   899 EVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWN 936
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
CTLH pfam10607
CTLH/CRA C-terminal to LisH motif domain; RanBPM is a scaffolding protein and is important in ...
 35-135 9.45e-03

CTLH/CRA C-terminal to LisH motif domain; RanBPM is a scaffolding protein and is important in regulating cellular function in both the immune system and the nervous system. This domain is at the C-terminus of the proteins and is the binding domain for the CRA motif (for CT11-RanBPM), which is comprised of approximately 100 amino acids at the C terminal of RanBPM. It was found to be important for the interaction of RanBPM with fragile X mental retardation protein (FMRP), but its functional significance has yet to be determined. This region contains CTLH and CRA domains annotated by SMART; however, these may be a single domain, and it is refereed to as a C-terminal to LisH motif.


Pssm-ID: 402305 [Multi-domain]  Cd Length: 143  Bit Score: 37.94  E-value: 9.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805    35 FFNMKYFEDEVHNGNWDEVEKYL----SGFTKVDDNrysmkIFFEIRKQKYLEALDRHDRPKAVDIlVKdlKVFSTFNEE 110
Cdd:pfam10607    2 FKERNRILEAILNGDITEAIEWCnenkPELLKINSN-----LEFELRLQQFIELIRSGKILEALEY-AR--ENLAPFNEE 73

                           90       100
                   ....*....|....*....|....*
gi 302393805   111 LFKEITQLLTLENFRENEQLSKYGD 135
Cdd:pfam10607   74 HLKELEKLMGLLAFPDPTDSSPYKS 98
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 359-667 7.71e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 143.63  E-value: 7.71e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  359 MSMDFHPIKQTLLlvgtnvgdiglweVGSRerlvQKTFKVWDLSKCSMPLQaalVKEPVVSVNRVIWSPDGSLFGVAYSR 438
Cdd:cd00200    13 TCVAFSPDGKLLA-------------TGSG----DGTIKVWDLETGELLRT---LKGHTGPVRDVAASADGTYLASGSSD 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  439 HIVQLYSYHGGEDMRqhlEIDAHVGGVNDIAFStPNKQLcVTTCGDDKTIKVWDAATGVKRYTFEGHEAPVYSICPHykE 518
Cdd:cd00200    73 KTIRLWDLETGECVR---TLTGHTSYVSSVAFS-PDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS--P 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  519 NIQFIFSTALDGKIKAWLYDNMGSRVDYEAPGRWCTTMAYSADGTRLFSCGTskDGESFIveWNESEGAVKRTYQGfHKR 598
Cdd:cd00200   146 DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS--DGTIKL--WDLSTGKCLGTLRG-HEN 220

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  599 SLGVVQFDTTKNRYLAAGDDFSIKFWDMDTIQLLTAIDA-DGGLQAsprIRFNKEGSLLAVSANDNMIKV 667
Cdd:cd00200   221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTS---LAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
393-679 1.21e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.65  E-value: 1.21e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  393 QKTFKVWDLSKcsmPLQAALVKEPVVSVNRVIWSPDGSLFGVAYSRHIVQLYSYHGGEDMRqhlEIDAHVGGVNDIAFSt 472
Cdd:COG2319    99 DGTVRLWDLAT---GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR---TLTGHSGAVTSVAFS- 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  473 PNKQLcVTTCGDDKTIKVWDAATGVKRYTFEGHEAPVYSIC--PhykeNIQFIFSTALDGKIKAWLYDNMGSRVDYEAPG 550
Cdd:COG2319   172 PDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAfsP----DGKLLASGSADGTVRLWDLATGKLLRTLTGHS 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  551 RWCTTMAYSADGTRLFSCgtSKDGESFIveWNESEGAVKRTYQGfHKRSLGVVQFdTTKNRYLA-AGDDFSIKFWDMDTI 629
Cdd:COG2319   247 GSVRSVAFSPDGRLLASG--SADGTVRL--WDLATGELLRTLTG-HSGGVNSVAF-SPDGKLLAsGSDDGTVRLWDLATG 320

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 302393805  630 QLLTAIDADGGLQASprIRFNKEGSLLAVSANDNMIKVMaNSDGLRLLHT 679
Cdd:COG2319   321 KLLRTLTGHTGAVRS--VAFSPDGKTLASGSDDGTVRLW-DLATGELLRT 367
WD40 COG2319
WD40 repeat [General function prediction only];
331-667 1.21e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.79  E-value: 1.21e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  331 AHGHNQTFKAPDDLPKTVARTLSQGSSPMSMDFHPIKQTLLLVGTNvGDIGLWEVGSRERLVQ----------------- 393
Cdd:COG2319    54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAD-GTVRLWDLATGLLLRTltghtgavrsvafspdg 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  394 ---------KTFKVWDLSKcsmPLQAALVKEPVVSVNRVIWSPDGSLFGVAYSRHIVQLYSYHGGEDMRqhlEIDAHVGG 464
Cdd:COG2319   133 ktlasgsadGTVRLWDLAT---GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR---TLTGHTGA 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  465 VNDIAFStPNKQLcVTTCGDDKTIKVWDAATGVKRYTFEGHEAPVYSIC--PhykeNIQFIFSTALDGKIKAWLYDNMGS 542
Cdd:COG2319   207 VRSVAFS-PDGKL-LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAfsP----DGRLLASGSADGTVRLWDLATGEL 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  543 RVDYEAPGRWCTTMAYSADGTRLFScgTSKDGEsfIVEWNESEGAVKRTYQGfHKRSLGVVQFDTTKNRYLAAGDDFSIK 622
Cdd:COG2319   281 LRTLTGHSGGVNSVAFSPDGKLLAS--GSDDGT--VRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDDGTVR 355

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 302393805  623 FWDMDTIQLLTAIDA-DGGLQAsprIRFNKEGSLLAVSANDNMIKV 667
Cdd:COG2319   356 LWDLATGELLRTLTGhTGAVTS---VAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
409-681 4.21e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.25  E-value: 4.21e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  409 QAALVKEPVVSVNRVIWSPDGSLFGVAYSRHIVQLYSYHGGEDMRQhleIDAHVGGVNDIAFStPNKQLCVTTcGDDKTI 488
Cdd:COG2319    70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRT---LTGHTGAVRSVAFS-PDGKTLASG-SADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  489 KVWDAATGVKRYTFEGHEAPVYSIC--PhykeNIQFIFSTALDGKIKAWLYDNMGSRVDYEAPGRWCTTMAYSADGTRLF 566
Cdd:COG2319   145 RLWDLATGKLLRTLTGHSGAVTSVAfsP----DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  567 SCgtSKDGEsfIVEWNESEGAVKRTYQGFHKRSLGVVqFdTTKNRYLA-AGDDFSIKFWDMDTIQLLTAIDADGGLQASp 645
Cdd:COG2319   221 SG--SADGT--VRLWDLATGKLLRTLTGHSGSVRSVA-F-SPDGRLLAsGSADGTVRLWDLATGELLRTLTGHSGGVNS- 293

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 302393805  646 rIRFNKEGSLLAVSANDNMIKVMANSDGlRLLHTVE 681
Cdd:COG2319   294 -VAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLT 327
WD40 COG2319
WD40 repeat [General function prediction only];
345-628 3.53e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 3.53e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  345 PKTVARTLSQGSSPMSMDFHPiKQTLLLVGTNVGDIGLWEVGSRERLVQ--------------------------KTFKV 398
Cdd:COG2319   110 GLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTltghsgavtsvafspdgkllasgsddGTVRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  399 WDLSkcSMPLQAALvKEPVVSVNRVIWSPDGSLFGVAYSRHIVQLYSYHGGEDMRqhlEIDAHVGGVNDIAFStPNKQLc 478
Cdd:COG2319   189 WDLA--TGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR---TLTGHSGSVRSVAFS-PDGRL- 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  479 VTTCGDDKTIKVWDAATGVKRYTFEGHEAPVYSIC--PhykeNIQFIFSTALDGKIKAWLYDNMGSRVDYEAPGRWCTTM 556
Cdd:COG2319   261 LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAfsP----DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 302393805  557 AYSADGTRLFSCgtSKDGEsfIVEWNESEGAVKRTYQGfHKRSLGVVQFDTTKNRYLAAGDDFSIKFWDMDT 628
Cdd:COG2319   337 AFSPDGKTLASG--SDDGT--VRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 455-667 5.45e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.27  E-value: 5.45e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  455 HLEIDAHVGGVNDIAFSTPNKQLCvtTCGDDKTIKVWDAATGVKRYTFEGHEAPVYSI--CPHYkeniQFIFSTALDGKI 532
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLA--TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVaaSADG----TYLASGSSDKTI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  533 KAWLYDNMGSRVDYEAPGRWCTTMAYSADGTRLFSCGTSKDgesfIVEWNESEGAVKRTYQGfHKRSLGVVQFDTTKNRY 612
Cdd:cd00200    76 RLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT----IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFV 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 302393805  613 LAAGDDFSIKFWDMDTIQLLTAIDA-DGGLQAsprIRFNKEGSLLAVSANDNMIKV 667
Cdd:cd00200   151 ASSSQDGTIKLWDLRTGKCVATLTGhTGEVNS---VAFSPDGEKLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
453-941 3.01e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 3.01e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  453 RQHLEIDAHVGGVNDIAFSTPNKQLcvTTCGDDKTIKVWDAATGVKRYTFEGHEAPVYSIcpHYKENIQFIFSTALDGKI 532
Cdd:COG2319    27 ALLLLLLGLAAAVASLAASPDGARL--AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV--AFSPDGRLLASASADGTV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  533 KAWLYDNMGSRVDYEAPGRWCTTMAYSADGTRLFScgTSKDGEsfIVEWNESEGAVKRTYQGfHKRSLGVVQFDTTKNRY 612
Cdd:COG2319   103 RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLAS--GSADGT--VRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLL 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  613 LAAGDDFSIKFWDMDTIQLLTAIDADGGLQASprIRFNKEGSLLAVSANDNMIKVmansdglrllhtvenlssesskpai 692
Cdd:COG2319   178 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS--VAFSPDGKLLASGSADGTVRL------------------------- 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  693 nsipmverpasvvsipgmngdsrnmvdvkpviteesndkskvWKLtevgepsqcrslrlpenmrvtkisrliftnsgnai 772
Cdd:COG2319   231 ------------------------------------------WDL----------------------------------- 233

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  773 lalasnaihllwkwqrndrnATGKATASLPPQQWqpasgilmtndvaetnpeeAVPCFALSKNDSYVMSASG-GKISLFN 851
Cdd:COG2319   234 --------------------ATGKLLRTLTGHSG-------------------SVRSVAFSPDGRLLASGSAdGTVRLWD 274

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  852 MMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQ 931
Cdd:COG2319   275 LATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353

                         490
                  ....*....|
gi 302393805  932 LCVWNTDGWE 941
Cdd:COG2319   354 VRLWDLATGE 363
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 501-936 3.74e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.01  E-value: 3.74e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  501 TFEGHEAPVYSICPHYKENiqFIFSTALDGKIKAWLYDNMGSRVDYEAPGRWCTTMAYSADGTRLFSCGTSKdgesFIVE 580
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGK--LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDK----TIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  581 WNESEGAVKRTYQGfHKRSLGVVQFdTTKNRYLAA-GDDFSIKFWDMDTIQLLTAIDadgGLQASPR-IRFNKEGSLLAV 658
Cdd:cd00200    78 WDLETGECVRTLTG-HTSYVSSVAF-SPDGRILSSsSRDKTIKVWDVETGKCLTTLR---GHTDWVNsVAFSPDGTFVAS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  659 SANDNMIKVmANSDGLRLLHTvenlssesskpainsipmverpasvvsIPGMNGDsrnmvdvkpviteesndkskvwklt 738
Cdd:cd00200   153 SSQDGTIKL-WDLRTGKCVAT---------------------------LTGHTGE------------------------- 179

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  739 evgepsqcrslrlpenmrvtkISRLIFTNSGNAILAlasnaihllwkwqrndrnatgkataslppqqwqpasgilmtndv 818
Cdd:cd00200   180 ---------------------VNSVAFSPDGEKLLS-------------------------------------------- 194

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  819 aetnpeeavpcfalskndsyvmSASGGKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVD 898
Cdd:cd00200   195 ----------------------SSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTG 251

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 302393805  899 EVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWN 936
Cdd:cd00200   252 ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
823-1035 3.22e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 3.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  823 PEEAVPCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVK 901
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLL 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  902 SKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDGWEKQksKVLQIPQGRSTSslsdtrVQFHQDQVHFLVVHETQ- 980
Cdd:COG2319   240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL--RTLTGHSGGVNS------VAFSPDGKLLASGSDDGt 311

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 302393805  981 LAIYETTKLECMKQWpvRESAAPITHATFSCDSQLIYTSFMDATICVFSSANLRL 1035
Cdd:COG2319   312 VRLWDLATGKLLRTL--TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 827-1082 8.13e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.30  E-value: 8.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  827 VPCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVKSKLK 905
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGdGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGECVRTLT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  906 GHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDgwEKQKSKVLQ-----------IPQGR--STSSLSDT-RV------- 964
Cdd:cd00200    91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE--TGKCLTTLRghtdwvnsvafSPDGTfvASSSQDGTiKLwdlrtgk 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  965 -----QFHQDQVHFLVVHET-----------QLAIYETTKLECMKQwpVRESAAPITHATFSCDSQLIYTSFMDATICVF 1028
Cdd:cd00200   169 cvatlTGHTGEVNSVAFSPDgekllssssdgTIKLWDLSTGKCLGT--LRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 302393805 1029 SSANLRLRcrvnpsaylpASLSNSNVHPLVIAAHPqESNMFAVGLSDGGVHIFE 1082
Cdd:cd00200   247 DLRTGECV----------QTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 34-92 1.82e-15

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 71.45  E-value: 1.82e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 302393805     34 FFFNMKYFEDEVHNGNWDEVEKYLSGFTKVDDNRYSmKIFFEIRKQKYLEALDRHDRPK 92
Cdd:smart00668    1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNS-KLEFELRKQKFLELVRQGKLEE 58
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 759-1029 2.22e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.15  E-value: 2.22e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  759 KISRLIFTNSGNAILALASNAIHLLWKWQRNDRNATGK------ATASLPPQQWQPASG---------ILMTNDVAET-- 821
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKghtgpvRDVAASADGTYLASGssdktirlwDLETGECVRTlt 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  822 NPEEAVPCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEV 900
Cdd:cd00200    91 GHTSYVSSVAFSPDGRILSSSSRdKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKC 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  901 KSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDgwEKQKSKVLQIPQGRSTSslsdtrVQFHQDQVHFLVVHETQ 980
Cdd:cd00200   170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS--TGKCLGTLRGHENGVNS------VAFSPDGYLLASGSEDG 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 302393805  981 -LAIYETTKLECMKQwpVRESAAPITHATFSCDSQLIYTSFMDATICVFS 1029
Cdd:cd00200   242 tIRVWDLRTGECVQT--LSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
773-1116 1.04e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.56  E-value: 1.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  773 LALASNAIHLLWKWQRNDRNATGKATASLPPQQWQPASGILMTNDVAETNPEEAVPCFALSKNDSYVMSASG-GKISLFN 851
Cdd:COG2319    27 ALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAdGTVRLWD 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  852 MMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQ 931
Cdd:COG2319   107 LATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  932 LCVWNTDGWEKQksKVLQIPQGRSTSslsdtrVQFHQDQvHFLVV--HETQLAIYETTKLECMKQWPVRESaaPITHATF 1009
Cdd:COG2319   186 VRLWDLATGKLL--RTLTGHTGAVRS------VAFSPDG-KLLASgsADGTVRLWDLATGKLLRTLTGHSG--SVRSVAF 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805 1010 SCDSQLIYTSFMDATICVFSSANLRLRcrvnpsaylpASLSNSNVHPLVIAAHPqESNMFAVGLSDGGVHIFEPleSEGK 1089
Cdd:COG2319   255 SPDGRLLASGSADGTVRLWDLATGELL----------RTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDL--ATGK 321

                         330       340       350
                  ....*....|....*....|....*....|
gi 302393805 1090 WGVAPPPENGSASAVTATPSvG---ASASD 1116
Cdd:COG2319   322 LLRTLTGHTGAVRSVAFSPD-GktlASGSD 350
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 869-1090 2.05e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 2.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  869 TFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTdgwekQKSKVL 948
Cdd:cd00200    13 TCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL-----ETGECV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  949 QIPQGrSTSSLSDtrVQFHQDQvHFLVV--HETQLAIYETTKLECMKQWPVREsaAPITHATFSCDSQLIYTSFMDATIC 1026
Cdd:cd00200    87 RTLTG-HTSYVSS--VAFSPDG-RILSSssRDKTIKVWDVETGKCLTTLRGHT--DWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302393805 1027 VFSSANLRLRcrvnpsaylpASLS--NSNVHplVIAAHPQESNMFAVGlSDGGVHIFEPleSEGKW 1090
Cdd:cd00200   161 LWDLRTGKCV----------ATLTghTGEVN--SVAFSPDGEKLLSSS-SDGTIKLWDL--STGKC 211
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 4-34 9.24e-06

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 43.19  E-value: 9.24e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 302393805      4 LSRELVFLILQFLDEEKFKETVHKLEQESGF 34
Cdd:smart00667    2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 899-936 2.52e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 2.52e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 302393805    899 EVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWN 936
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 451-492 3.13e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 3.13e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 302393805    451 DMRQHLEIDAHVGGVNDIAFStPNKQLCVTtCGDDKTIKVWD 492
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFS-PDGKYLAS-GSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
457-492 9.92e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 9.92e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 302393805   457 EIDAHVGGVNDIAFStPNKQLCVTtCGDDKTIKVWD 492
Cdd:pfam00400    6 TLEGHTGSVTSLAFS-PDGKLLAS-GSDDGTVKVWD 39
PTZ00249 PTZ00249
variable surface protein Vir28; Provisional
 190-314 1.00e-04

variable surface protein Vir28; Provisional


Pssm-ID: 140276 [Multi-domain]  Cd Length: 516  Bit Score: 46.18  E-value: 1.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  190 RPNPDIKTLFVDHSCRLPNDARAPSPVNnpllGSLPKAEGFPPLGAHGP------------FQPTPSPVPTPLAGWMSSP 257
Cdd:PTZ00249  238 RPPKHISFSSPHAHGRPPVETRPPNPVS----VSSPQAHGRHPGETHTPplvtvpsskahdRNPVQTPTPTSVSGYSSQA 313

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 302393805  258 SSVPHPAVSGGPIALGAPSIQAALKHPRTPPSNSAVDYPSGDSDHVSKRTRPMGISD 314
Cdd:PTZ00249  314 KGLEKQAGGESERTSSVPSEQFPLPLPVLLPLGQSGPLESSESEETDEYAGPKGLPE 370
PHA03247 PHA03247
large tegument protein UL36; Provisional
 200-360 2.10e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 2.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  200 VDHSCRLPNDARAPSPVNNPllgslpkAEGFPPLGAHGPFQPTPSPVPTPLAGWMSSPSSVPHPAVSGGPIALGAPsiqa 279
Cdd:PHA03247  244 ISHPLRGDIAAPAPPPVVGE-------GADRAPETARGATGPPPPPEAAAPNGAAAPPDGVWGAALAGAPLALPAP---- 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  280 alkhPRTPPSNSAVD-----------------------YPSGdsdhVSKRTRPMGISdevslgvnmlPMTFPGQAHGHNQ 336
Cdd:PHA03247  313 ----PDPPPPAPAGDaeeeddedgamevvsplprprqhYPLG----FPKRRRPTWTP----------PSSLEDLSAGRHH 374

                         170       180
                  ....*....|....*....|....
gi 302393805  337 TFKAPddLPKTVARTLSQGSSPMS 360
Cdd:PHA03247  375 PKRAS--LPTRKRRSARHAATPFA 396
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 5-33 2.53e-04

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 39.30  E-value: 2.53e-04
                           10        20
                   ....*....|....*....|....*....
gi 302393805     5 SRELVFLILQFLDEEKFKETVHKLEQESG 33
Cdd:pfam17814    1 SQDVVRLILQFLKENGLHRTLQALQTESG 29
PTZ00420 PTZ00420
coronin; Provisional
 871-959 2.64e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 2.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  871 LAFHPQDNNIIAIGMDDSTIQIYNVR-----VDEVKSK---LKGHSKRITGLAFsNVLN--VLVSSGADAQLCVWNTdgw 940
Cdd:PTZ00420   80 LQFNPCFSEILASGSEDLTIRVWEIPhndesVKEIKDPqciLKGHKKKISIIDW-NPMNyyIMCSSGFDSFVNIWDI--- 155

                          90
                  ....*....|....*....
gi 302393805  941 EKQKsKVLQIPQGRSTSSL 959
Cdd:PTZ00420  156 ENEK-RAFQINMPKKLSSL 173
WD40 pfam00400
WD domain, G-beta repeat;
899-936 2.98e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.98e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 302393805   899 EVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWN 936
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 200-300 4.06e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 4.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  200 VDHSCRLPNDARAPSPVNNPLLGSLPKAEGFPPLGAHGPFQP-TPSPVPTPLAGWM-SSPSSVPHPAVSGGPIALGAPSI 277
Cdd:PHA03247 2695 LTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPaAPAPPAVPAGPATpGGPARPARPPTTAGPPAPAPPAA 2774

                          90       100
                  ....*....|....*....|...
gi 302393805  278 QAALKHPRTPPSNSAVDYPSGDS 300
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRES 2797
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
207-288 2.49e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 2.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805  207 PNDARAPSPVNnPLLGSLPKAEGFPPLGAHGPFQPTPSPVPTPLAGWM-SSPSSVPHPAVSGGPIALGAPSIQAALKHPR 285
Cdd:PRK12323  417 RAVAAAPARRS-PAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARpAAAGPRPVAAAAAAAPARAAPAAAPAPADDD 495


                  ...
gi 302393805  286 TPP 288
Cdd:PRK12323  496 PPP 498
WD40 pfam00400
WD domain, G-beta repeat;
496-535 3.39e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 3.39e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 302393805   496 GVKRYTFEGHEAPVYSICPHYKENiqFIFSTALDGKIKAW 535
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
CTLH pfam10607
CTLH/CRA C-terminal to LisH motif domain; RanBPM is a scaffolding protein and is important in ...
 35-135 9.45e-03

CTLH/CRA C-terminal to LisH motif domain; RanBPM is a scaffolding protein and is important in regulating cellular function in both the immune system and the nervous system. This domain is at the C-terminus of the proteins and is the binding domain for the CRA motif (for CT11-RanBPM), which is comprised of approximately 100 amino acids at the C terminal of RanBPM. It was found to be important for the interaction of RanBPM with fragile X mental retardation protein (FMRP), but its functional significance has yet to be determined. This region contains CTLH and CRA domains annotated by SMART; however, these may be a single domain, and it is refereed to as a C-terminal to LisH motif.


Pssm-ID: 402305 [Multi-domain]  Cd Length: 143  Bit Score: 37.94  E-value: 9.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302393805    35 FFNMKYFEDEVHNGNWDEVEKYL----SGFTKVDDNrysmkIFFEIRKQKYLEALDRHDRPKAVDIlVKdlKVFSTFNEE 110
Cdd:pfam10607    2 FKERNRILEAILNGDITEAIEWCnenkPELLKINSN-----LEFELRLQQFIELIRSGKILEALEY-AR--ENLAPFNEE 73

                           90       100
                   ....*....|....*....|....*
gi 302393805   111 LFKEITQLLTLENFRENEQLSKYGD 135
Cdd:pfam10607   74 HLKELEKLMGLLAFPDPTDSSPYKS 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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