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Conserved domains on  [gi|727863578|sp|Q0VF49|]
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RecName: Full=Uncharacterized protein KIAA2012

Protein Classification

DUF4670 domain-containing protein( domain architecture ID 12174332)

DUF4670 domain-containing protein similar to Homo sapiens protein KIAA2012

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 659-1171 0e+00

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


:

Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 586.53  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578   659 YETSPLTQTTEKQGAQQSLEAAAQKTGEPQSCINKALICSNRKEFYTRKLHIDMTPFLKESGNALDYQEEAGRPLRETHH 738
Cdd:pfam15709    1 KETSPLTQTTEEQGAQQSLEAAAQKTGEPQSCINKGLICSNRKEFYTRKLHIDMTPFLKDSGEALDSHEEPGEPLGENHQ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578   739 NDQDPEPRSMTLDSPRASRTEHIQTPEADIVQKV-GRDYDVHHLHRGLLGYGPESPERLSAVYTSLLPREREGKAEPRLF 817
Cdd:pfam15709   81 DSQDPEPRSVTLSPLSASLGEHIQTPEADTVQNGdGEDYDVHHLHRGLPRHRPESPEKLTAVDTSLLPRAREGKTEPRLF 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578   818 SQETSANISH-ERDLINEAKRKEKPKKDKTKGPKSEREGKVYGQAEAAIGKS-----KDSKAKKKLEKKTRPQRKRTQKE 891
Cdd:pfam15709  161 NQETPASISHaERELIDKAKRRKGTKTDKTKTPKREREGKVHGEAEAAVGKSreskaEKKSELISKGKKTGAKRKRTQKE 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578   892 RNLEIAAELSGPDV-SYEETEDTSNRGSFASDSFVEDPWLSPKYDAQESQVSLDGRSSPSQIATVTGNMESKEERRCEDP 970
Cdd:pfam15709  241 RNLEVAAELSGPDViNSKETEDASERGAFSSDSVVEDPWLSSKYDAEESQVSIDGRSSPTQTFVVTGNMESEEERSEEDP 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578   971 SKALLTKREQEKASWDRLRAERAEMRWLEVEKKRREQEEQRQLQQEQLERAKKMEEELELEQQRRTEEIRLRKQRLQEEQ 1050
Cdd:pfam15709  321 SKALLEKREQEKASRDRLRAERAEMRRLEVERKRREQEEQRRLQQEQLERAEKMREELELEQQRRFEEIRLRKQRLEEER 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578  1051 QRQEEEERKQQLRLKAAQERARQQQEEFRRKLRELQRKKQQEEAERAEAEKQRQEELEMQLEEEQKHLMEMAEEERLEYQ 1130
Cdd:pfam15709  401 QRQEEEERKQRLQLQAAQERARQQQEEFRRKLQELQRKKQQEEAERAEAEKQRQKELEMQLAEEQKRLMEMAEEERLEYQ 480

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|.
gi 727863578  1131 RRKQEAEEKARLEAEERRQKEEEAARLALEEATKQAQEQAR 1171
Cdd:pfam15709  481 RQKQEAEEKARLEAEERRQKEEEAARLALEEAMKQAQEQAR 521
 
Name Accession Description Interval E-value
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 659-1171 0e+00

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 586.53  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578   659 YETSPLTQTTEKQGAQQSLEAAAQKTGEPQSCINKALICSNRKEFYTRKLHIDMTPFLKESGNALDYQEEAGRPLRETHH 738
Cdd:pfam15709    1 KETSPLTQTTEEQGAQQSLEAAAQKTGEPQSCINKGLICSNRKEFYTRKLHIDMTPFLKDSGEALDSHEEPGEPLGENHQ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578   739 NDQDPEPRSMTLDSPRASRTEHIQTPEADIVQKV-GRDYDVHHLHRGLLGYGPESPERLSAVYTSLLPREREGKAEPRLF 817
Cdd:pfam15709   81 DSQDPEPRSVTLSPLSASLGEHIQTPEADTVQNGdGEDYDVHHLHRGLPRHRPESPEKLTAVDTSLLPRAREGKTEPRLF 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578   818 SQETSANISH-ERDLINEAKRKEKPKKDKTKGPKSEREGKVYGQAEAAIGKS-----KDSKAKKKLEKKTRPQRKRTQKE 891
Cdd:pfam15709  161 NQETPASISHaERELIDKAKRRKGTKTDKTKTPKREREGKVHGEAEAAVGKSreskaEKKSELISKGKKTGAKRKRTQKE 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578   892 RNLEIAAELSGPDV-SYEETEDTSNRGSFASDSFVEDPWLSPKYDAQESQVSLDGRSSPSQIATVTGNMESKEERRCEDP 970
Cdd:pfam15709  241 RNLEVAAELSGPDViNSKETEDASERGAFSSDSVVEDPWLSSKYDAEESQVSIDGRSSPTQTFVVTGNMESEEERSEEDP 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578   971 SKALLTKREQEKASWDRLRAERAEMRWLEVEKKRREQEEQRQLQQEQLERAKKMEEELELEQQRRTEEIRLRKQRLQEEQ 1050
Cdd:pfam15709  321 SKALLEKREQEKASRDRLRAERAEMRRLEVERKRREQEEQRRLQQEQLERAEKMREELELEQQRRFEEIRLRKQRLEEER 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578  1051 QRQEEEERKQQLRLKAAQERARQQQEEFRRKLRELQRKKQQEEAERAEAEKQRQEELEMQLEEEQKHLMEMAEEERLEYQ 1130
Cdd:pfam15709  401 QRQEEEERKQRLQLQAAQERARQQQEEFRRKLQELQRKKQQEEAERAEAEKQRQKELEMQLAEEQKRLMEMAEEERLEYQ 480

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|.
gi 727863578  1131 RRKQEAEEKARLEAEERRQKEEEAARLALEEATKQAQEQAR 1171
Cdd:pfam15709  481 RQKQEAEEKARLEAEERRQKEEEAARLALEEAMKQAQEQAR 521
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1066-1171 1.09e-08

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 58.66  E-value: 1.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578 1066 AAQERARQQQEEFRRKLRELQRKKQQEEAERAEAEKQrqeelemqlEEEQKHLMEMaEEERLEYQRRKQEAEEKARLEAE 1145
Cdd:PRK09510   60 VVEQYNRQQQQQKSAKRAEEQRKKKEQQQAEELQQKQ---------AAEQERLKQL-EKERLAAQEQKKQAEEAAKQAAL 129

                          90       100
                  ....*....|....*....|....*.
gi 727863578 1146 ERRQKEEEAARlALEEATKQAQEQAR 1171
Cdd:PRK09510  130 KQKQAEEAAAK-AAAAAKAKAEAEAK 154
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1063-1174 5.46e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.16  E-value: 5.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578 1063 RLKAAQERARQQQEEFRRKLRELQRKKQQEEAERAEAEKQRQEELEMQLEEEQkhlmEMAEEERLEYQRRKQEAEEKARL 1142
Cdd:COG1196   271 ELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEE----ELAELEEELEELEEELEELEEEL 346

                          90       100       110
                  ....*....|....*....|....*....|..
gi 727863578 1143 EAEERRQKEEEAARLALEEATKQAQEQARYWI 1174
Cdd:COG1196   347 EEAEEELEEAEAELAEAEEALLEAEAELAEAE 378
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1041-1171 5.21e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 40.60  E-value: 5.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578  1041 LRKQRLqeeqqrqeeeerkqqlrlkaaQERARQQQEEFRRKLRELQRKKQQEEAERAEAEKQrqeelemqleeeqkhlme 1120
Cdd:TIGR02794   80 AEKQRA---------------------AEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQ------------------ 120

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 727863578  1121 mAEEerleyQRRKQEAEEKARLEAEERRQKEEEAARLALEEATKQAQEQAR 1171
Cdd:TIGR02794  121 -AEE-----AKAKQAAEAKAKAEAEAERKAKEEAAKQAEEEAKAKAAAEAK 165
 
Name Accession Description Interval E-value
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 659-1171 0e+00

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 586.53  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578   659 YETSPLTQTTEKQGAQQSLEAAAQKTGEPQSCINKALICSNRKEFYTRKLHIDMTPFLKESGNALDYQEEAGRPLRETHH 738
Cdd:pfam15709    1 KETSPLTQTTEEQGAQQSLEAAAQKTGEPQSCINKGLICSNRKEFYTRKLHIDMTPFLKDSGEALDSHEEPGEPLGENHQ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578   739 NDQDPEPRSMTLDSPRASRTEHIQTPEADIVQKV-GRDYDVHHLHRGLLGYGPESPERLSAVYTSLLPREREGKAEPRLF 817
Cdd:pfam15709   81 DSQDPEPRSVTLSPLSASLGEHIQTPEADTVQNGdGEDYDVHHLHRGLPRHRPESPEKLTAVDTSLLPRAREGKTEPRLF 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578   818 SQETSANISH-ERDLINEAKRKEKPKKDKTKGPKSEREGKVYGQAEAAIGKS-----KDSKAKKKLEKKTRPQRKRTQKE 891
Cdd:pfam15709  161 NQETPASISHaERELIDKAKRRKGTKTDKTKTPKREREGKVHGEAEAAVGKSreskaEKKSELISKGKKTGAKRKRTQKE 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578   892 RNLEIAAELSGPDV-SYEETEDTSNRGSFASDSFVEDPWLSPKYDAQESQVSLDGRSSPSQIATVTGNMESKEERRCEDP 970
Cdd:pfam15709  241 RNLEVAAELSGPDViNSKETEDASERGAFSSDSVVEDPWLSSKYDAEESQVSIDGRSSPTQTFVVTGNMESEEERSEEDP 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578   971 SKALLTKREQEKASWDRLRAERAEMRWLEVEKKRREQEEQRQLQQEQLERAKKMEEELELEQQRRTEEIRLRKQRLQEEQ 1050
Cdd:pfam15709  321 SKALLEKREQEKASRDRLRAERAEMRRLEVERKRREQEEQRRLQQEQLERAEKMREELELEQQRRFEEIRLRKQRLEEER 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578  1051 QRQEEEERKQQLRLKAAQERARQQQEEFRRKLRELQRKKQQEEAERAEAEKQRQEELEMQLEEEQKHLMEMAEEERLEYQ 1130
Cdd:pfam15709  401 QRQEEEERKQRLQLQAAQERARQQQEEFRRKLQELQRKKQQEEAERAEAEKQRQKELEMQLAEEQKRLMEMAEEERLEYQ 480

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|.
gi 727863578  1131 RRKQEAEEKARLEAEERRQKEEEAARLALEEATKQAQEQAR 1171
Cdd:pfam15709  481 RQKQEAEEKARLEAEERRQKEEEAARLALEEAMKQAQEQAR 521
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1066-1171 1.09e-08

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 58.66  E-value: 1.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578 1066 AAQERARQQQEEFRRKLRELQRKKQQEEAERAEAEKQrqeelemqlEEEQKHLMEMaEEERLEYQRRKQEAEEKARLEAE 1145
Cdd:PRK09510   60 VVEQYNRQQQQQKSAKRAEEQRKKKEQQQAEELQQKQ---------AAEQERLKQL-EKERLAAQEQKKQAEEAAKQAAL 129

                          90       100
                  ....*....|....*....|....*.
gi 727863578 1146 ERRQKEEEAARlALEEATKQAQEQAR 1171
Cdd:PRK09510  130 KQKQAEEAAAK-AAAAAKAKAEAEAK 154
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1065-1171 2.13e-08

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 57.89  E-value: 2.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578 1065 KAAQERARQQQEEfRRKLRELQRKKQQEEAERAEAEKQRQEELEMQLEEEQKHLMEMAEEERLEYQRRKQEAEEKARLEA 1144
Cdd:PRK09510   95 KQAAEQERLKQLE-KERLAAQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAKAKAEAEAKRAAAAAKKAAAEAKKKAEA 173

                          90       100
                  ....*....|....*....|....*..
gi 727863578 1145 EERRQKEEEAARLALEEATKQAQEQAR 1171
Cdd:PRK09510  174 EAAKKAAAEAKKKAEAEAAAKAAAEAK 200
PTZ00121 PTZ00121
MAEBL; Provisional
 960-1171 6.91e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.99  E-value: 6.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578  960 ESKEERRCEDPSKALLTKREQEKASWDRLRAEraEMRWLEVEKKRREQEEQRQLQQEQLERAKKMEEELELEQQRRTEEI 1039
Cdd:PTZ00121 1553 KAEELKKAEEKKKAEEAKKAEEDKNMALRKAE--EAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEE 1630

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578 1040 RLRKQRLQEEQQRQEEEERKqqlRLKAAQERARQQQEEFRRKLRELQRKKQQeeAERAEAEKQRqeelemqleeEQKHLM 1119
Cdd:PTZ00121 1631 EKKKVEQLKKKEAEEKKKAE---ELKKAEEENKIKAAEEAKKAEEDKKKAEE--AKKAEEDEKK----------AAEALK 1695

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 727863578 1120 EMAEEERLEYQRRKQEAEEKARleAEERRqKEEEAARLALEEATKQAQEQAR 1171
Cdd:PTZ00121 1696 KEAEEAKKAEELKKKEAEEKKK--AEELK-KAEEENKIKAEEAKKEAEEDKK 1744
PTZ00121 PTZ00121
MAEBL; Provisional
 962-1171 4.53e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.83  E-value: 4.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578  962 KEERRCEDPSKALLTKREQEkASWDRLRAERAE-MRWLEVEKKRREQEEQRQLQQEQLERA---KKMEEELELEQQRRTE 1037
Cdd:PTZ00121 1215 EEARKAEDAKKAEAVKKAEE-AKKDAEEAKKAEeERNNEEIRKFEEARMAHFARRQAAIKAeeaRKADELKKAEEKKKAD 1293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578 1038 EIRLRKQRLQEEQQRQEEEERKQQLRLKAAQERARQQQEEFRRKLRELQRKKQQEEAERAEAEKQRQEELEMQLEEEQKh 1117
Cdd:PTZ00121 1294 EAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKK- 1372

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727863578 1118 lmemAEEERLEYQRRKQEAEEKARLE-----AEERRQKEEE-----AARLALEEATKQAQEQAR 1171
Cdd:PTZ00121 1373 ----KEEAKKKADAAKKKAEEKKKADeakkkAEEDKKKADElkkaaAAKKKADEAKKKAEEKKK 1432
Radial_spoke_3 pfam06098
Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) ...
 1118-1171 4.89e-05

Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) sequences. Eukaryotic cilia and flagella present in diverse types of cells perform motile, sensory, and developmental functions in organizms from protists to humans. They are centred by precisely organized, microtubule-based structures, the axonemes. The axoneme consists of two central singlet microtubules, called the central pair, and nine outer doublet microtubules. These structures are well-conserved during evolution. The outer doublet microtubules, each composed of A and B sub-fibres, are connected to each other by nexin links, while the central pair is held at the centre of the axoneme by radial spokes. The radial spokes are T-shaped structures extending from the A-tubule of each outer doublet microtubule to the centre of the axoneme. Radial spoke protein 3 (RSP3), is present at the proximal end of the spoke stalk and helps in anchoring the radial spoke to the outer doublet. It is thought that radial spokes regulate the activity of inner arm dynein through protein phosphorylation and dephosphorylation.


Pssm-ID: 461827  Cd Length: 286  Bit Score: 46.48  E-value: 4.89e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727863578  1118 LMEMAEEERLEYQRRKQEA------EEKA---RLEAEERRQKEEEAARLALEEATKQAQEQAR 1171
Cdd:pfam06098  146 LLEVLEEEELANLREQQRAfeelrnAELAevqRLEEQERRLREEKERRIAQQREALKKEKETA 208
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1069-1171 1.27e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 46.27  E-value: 1.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578  1069 ERARQQQEEFRRKLRELQRKKQQEEAERAEAEK-----QRQEELEMQLEEEQKHLMEMAEEERL-----EYQRRKQEAEE 1138
Cdd:pfam17380  463 ERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKilekeLEERKQAMIEEERKRKLLEKEMEERQkaiyeEERRREAEEER 542

                           90       100       110
                   ....*....|....*....|....*....|...
gi 727863578  1139 KARLEAEERRQKEEEAARLALEEATKQAQEQAR 1171
Cdd:pfam17380  543 RKQQEMEERRRIQEQMRKATEERSRLEAMERER 575
ERM_helical pfam20492
Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related ...
 1063-1168 1.78e-04

Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related proteins, ezrin, radixin and moesin. Ezrin was first identified as a constituent of microvilli, radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions, and moesin as a heparin binding protein. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein). ERM molecules contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain and a charged C-terminal domain (pfam00769). Ezrin, radixin and merlin also contain a polyproline linker region between the helical and C-terminal domains. The N-terminal domain is highly conserved and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain. ERM proteins crosslink actin filaments with plasma membranes. They co-localize with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains. This is the alpha-helical domain, which is involved in intramolecular masking of protein-protein interaction sites, regulating the activity of this proteins.


Pssm-ID: 466641 [Multi-domain]  Cd Length: 120  Bit Score: 42.21  E-value: 1.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578  1063 RLKAAQE---RARQQQEEFRRKLRELQRKKQQEEAERAEAEKQRQEELEMQLEEEQKHLMEMAEEERLEyqRRKQEAEEK 1139
Cdd:pfam20492   14 RLKQYEEetkKAQEELEESEETAEELEEERRQAEEEAERLEQKRQEAEEEKERLEESAEMEAEEKEQLE--AELAEAQEE 91

                           90       100
                   ....*....|....*....|....*....
gi 727863578  1140 ARLEAEERRQKEEEAARlaLEEATKQAQE 1168
Cdd:pfam20492   92 IARLEEEVERKEEEARR--LQEELEEARE 118
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 1068-1171 2.55e-04

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 42.72  E-value: 2.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578  1068 QERARQQQEEFRRKLRELQRKKQQEEAERAEAEKQRQEELEMQLEEEQKHLmemAEEERLEyqRRKQEAEEKARLEaeer 1147
Cdd:pfam05672   30 EEQERLEKEEEERLRKEELRRRAEEERARREEEARRLEEERRREEEERQRK---AEEEAEE--REQREQEEQERLQ---- 100

                           90       100
                   ....*....|....*....|....
gi 727863578  1148 RQKEEEAARlALEEATKQAQEQAR 1171
Cdd:pfam05672  101 KQKEEAEAK-AREEAERQRQEREK 123
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1063-1174 5.46e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.16  E-value: 5.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578 1063 RLKAAQERARQQQEEFRRKLRELQRKKQQEEAERAEAEKQRQEELEMQLEEEQkhlmEMAEEERLEYQRRKQEAEEKARL 1142
Cdd:COG1196   271 ELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEE----ELAELEEELEELEEELEELEEEL 346

                          90       100       110
                  ....*....|....*....|....*....|..
gi 727863578 1143 EAEERRQKEEEAARLALEEATKQAQEQARYWI 1174
Cdd:COG1196   347 EEAEEELEEAEAELAEAEEALLEAEAELAEAE 378
PTZ00121 PTZ00121
MAEBL; Provisional
 960-1171 9.85e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 9.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578  960 ESKEERRCEDPSKALLTKREQEKASWDRLRAERAEMRWL-EVEKKRREQEEQRQLQQEQLERAKKMEEELELEQQRRTEE 1038
Cdd:PTZ00121 1279 KADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKAdEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADE 1358

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578 1039 IRLRKQRLQEEQQRQEEEERKqQLRLKAAQERARqQQEEFRRKLRELQRKKQQEEAERAEAEKQRQEELEMQLEEEQKHL 1118
Cdd:PTZ00121 1359 AEAAEEKAEAAEKKKEEAKKK-ADAAKKKAEEKK-KADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEA 1436

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 727863578 1119 MEMAEEERlEYQRRKQEAEEKARleAEERRQKEEEAARlaLEEATKQAQEQAR 1171
Cdd:PTZ00121 1437 KKKAEEAK-KADEAKKKAEEAKK--AEEAKKKAEEAKK--ADEAKKKAEEAKK 1484
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1037-1171 9.99e-04

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 42.87  E-value: 9.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578 1037 EEIRLRKQRLQEEQQRqeeeerKQQLRLKAAQEraRQQQEEFRRKLRELQRKKQQEEAERAEAEKQRQEELEMQLEEEQK 1116
Cdd:PRK09510   90 EELQQKQAAEQERLKQ------LEKERLAAQEQ--KKQAEEAAKQAALKQKQAEEAAAKAAAAAKAKAEAEAKRAAAAAK 161

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 727863578 1117 HLMEMAEEERLEYQRRKQEAEEKARLEAEERRQKEEEAARLALEEATKQAQEQAR 1171
Cdd:PRK09510  162 KAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAK 216
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 950-1173 2.38e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.23  E-value: 2.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578  950 SQIATVTGNMESKEERRcedpsKALLTKREQEKASWDRLRAERAEmrwlevekkrreqeeqrqlQQEQLERAKKmEEELE 1029
Cdd:COG1196   295 AELARLEQDIARLEERR-----RELEERLEELEEELAELEEELEE-------------------LEEELEELEE-ELEEA 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578 1030 LEQQRRTEEIRLRKQRLQEEQQRQEEEERKQQLRLKAAQERARQQQEEFRRKLRELQRKKQQEEAERAEAEKQRQEELEM 1109
Cdd:COG1196   350 EEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEA 429

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727863578 1110 QLEEEQKHLME-MAEEERLEYQRRKQEAEEKARLEAEERRQKEEEAARLALEEATKQAQEQARYW 1173
Cdd:COG1196   430 LAELEEEEEEEeEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLL 494
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 1065-1154 2.42e-03

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 39.64  E-value: 2.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578  1065 KAAQERARQQQEEFRRKLRELQRKKQQeeaeraeaeKQRQEELEMQLEEEQKHLMEMAEEERLEYQRRKQEAEEKARLEA 1144
Cdd:pfam05672   51 RAEEERARREEEARRLEEERRREEEER---------QRKAEEEAEEREQREQEEQERLQKQKEEAEAKAREEAERQRQER 121

                           90
                   ....*....|
gi 727863578  1145 EERRQKEEEA 1154
Cdd:pfam05672  122 EKIMQQEEQE 131
Casc1_N pfam15927
Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally ...
 1132-1171 3.11e-03

Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 200 amino acids in length. The family is found in association with pfam12366. There are two completely conserved residues (N and W) that may be functionally important.


Pssm-ID: 464947 [Multi-domain]  Cd Length: 201  Bit Score: 40.42  E-value: 3.11e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 727863578  1132 RKQEAEEKARLEAEERRQKEEEAARLALEEATKQAQEQAR 1171
Cdd:pfam15927    1 ARLREEEEERLRAEEEEAERLEEERREEEEEERLAAEQDR 40
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
1066-1167 3.37e-03

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 41.40  E-value: 3.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578 1066 AAQERARQ-QQEEFRRKlRELQRKKQQEEAERAEAEKQRQEELEMQLEEEQKHLmEMAEEERLEyQRRKQEAEEKARLEA 1144
Cdd:COG2268   240 AEAEAELAkKKAEERRE-AETARAEAEAAYEIAEANAEREVQRQLEIAEREREI-ELQEKEAER-EEAELEADVRKPAEA 316

                          90       100
                  ....*....|....*....|....*
gi 727863578 1145 EERRQKEEEAARL--ALEEATKQAQ 1167
Cdd:COG2268   317 EKQAAEAEAEAEAeaIRAKGLAEAE 341
Casc1_N pfam15927
Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally ...
 1120-1160 4.05e-03

Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 200 amino acids in length. The family is found in association with pfam12366. There are two completely conserved residues (N and W) that may be functionally important.


Pssm-ID: 464947 [Multi-domain]  Cd Length: 201  Bit Score: 40.04  E-value: 4.05e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 727863578  1120 EMAEEERLEYQRRKQEAEEKARLEAEERRQKEEEAARLALE 1160
Cdd:pfam15927    4 REEEEERLRAEEEEAERLEEERREEEEEERLAAEQDRRAEE 44
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1041-1171 5.21e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 40.60  E-value: 5.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578  1041 LRKQRLqeeqqrqeeeerkqqlrlkaaQERARQQQEEFRRKLRELQRKKQQEEAERAEAEKQrqeelemqleeeqkhlme 1120
Cdd:TIGR02794   80 AEKQRA---------------------AEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQ------------------ 120

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 727863578  1121 mAEEerleyQRRKQEAEEKARLEAEERRQKEEEAARLALEEATKQAQEQAR 1171
Cdd:TIGR02794  121 -AEE-----AKAKQAAEAKAKAEAEAERKAKEEAAKQAEEEAKAKAAAEAK 165
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1065-1170 8.08e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.31  E-value: 8.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578 1065 KAAQERARQQQEEFRRKLRELQRKKQQEEAERAEAEKQRQEELEMQLEEEQKHLMEMAEEERLEYQRRKQEAEEKARLEA 1144
Cdd:COG1196   398 LAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEA 477

                          90       100
                  ....*....|....*....|....*.
gi 727863578 1145 EERRQKEEEAARLALEEATKQAQEQA 1170
Cdd:COG1196   478 ALAELLEELAEAAARLLLLLEAEADY 503
CCDC34 pfam13904
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
 1066-1170 8.90e-03

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 38.92  E-value: 8.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578  1066 AAQERARQQQEEFRRKLRE-------LQRKKQQEEAERAEAEKQRQEELEMQLEEEQKH--LMEMAEEERLEYQRRKQEA 1136
Cdd:pfam13904   75 QKEEREKEEQEAELRKRLAkekyqewLQRKARQQTKKREESHKQKAAESASKSLAKPERkvSQEEAKEVLQEWERKKLEQ 154

                           90       100       110
                   ....*....|....*....|....*....|....
gi 727863578  1137 EEKARLEAEERRQKEEEaarlaLEEATKQAQEQA 1170
Cdd:pfam13904  155 QQRKREEEQREQLKKEE-----EEQERKQLAEKA 183
TolA COG3064
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
1063-1171 9.19e-03

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442298 [Multi-domain]  Cd Length: 485  Bit Score: 40.02  E-value: 9.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727863578 1063 RLKAAQERARQQQEEFRRKLRELQRKKQQEEAERAEAEKQRQEELEMQLEEEQKHLMEMAEEERLEYQRRKQEAEEKARL 1142
Cdd:COG3064    31 AEQKAKEEAEEERLAELEAKRQAEEEAREAKAEAEQRAAELAAEAAKKLAEAEKAAAEAEKKAAAEKAKAAKEAEAAAAA 110

                          90       100       110
                  ....*....|....*....|....*....|..
gi 727863578 1143 E---AEERRQKEEEAARLALEEATKQAQEQAR 1171
Cdd:COG3064   111 EkaaAAAEKEKAEEAKRKAEEEAKRKAEEERK 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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