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Conserved domains on  [gi|122300998|sp|Q088X9|]
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RecName: Full=Pyrimidine/purine nucleoside phosphorylase; AltName: Full=Adenosine phosphorylase; AltName: Full=Cytidine phosphorylase; AltName: Full=Guanosine phosphorylase; AltName: Full=Inosine phosphorylase; AltName: Full=Thymidine phosphorylase; AltName: Full=Uridine phosphorylase; AltName: Full=Xanthosine phosphorylase

Protein Classification

pyrimidine/purine nucleoside phosphorylase( domain architecture ID 10536379)

pyrimidine/purine nucleoside phosphorylase catalyzes the phosphorolysis of diverse nucleosides, such as uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine, yielding D-ribose 1-phosphate and the respective free bases; also catalyzes the reverse reactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ppnp pfam06865
Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. ...
 11-102 1.39e-49

Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. YaiE from E. coli catalyzes phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and free bases.


:

Pssm-ID: 462023  Cd Length: 92  Bit Score: 151.87  E-value: 1.39e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122300998   11 KKANVYFNGKVISRSVVLADGSKQTFGVVLPGEYEFSTAQGEIMQVISGKFDVLLPGKTEWVAYAEASQFELAPNVSFSI 90
Cdd:pfam06865   1 KKANVYFDGKVTSRTFEFADGSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWKTYAAGESFEVPANSSFDL 80

                          90
                  ....*....|..
gi 122300998   91 RTDQISEYCCQY 102
Cdd:pfam06865  81 KVKEVTDYLCSY 92
 
Name Accession Description Interval E-value
Ppnp pfam06865
Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. ...
 11-102 1.39e-49

Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. YaiE from E. coli catalyzes phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and free bases.


Pssm-ID: 462023  Cd Length: 92  Bit Score: 151.87  E-value: 1.39e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122300998   11 KKANVYFNGKVISRSVVLADGSKQTFGVVLPGEYEFSTAQGEIMQVISGKFDVLLPGKTEWVAYAEASQFELAPNVSFSI 90
Cdd:pfam06865   1 KKANVYFDGKVTSRTFEFADGSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWKTYAAGESFEVPANSSFDL 80

                          90
                  ....*....|..
gi 122300998   91 RTDQISEYCCQY 102
Cdd:pfam06865  81 KVKEVTDYLCSY 92
PpnP COG3123
Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide ...
 6-101 1.55e-46

Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide transport and metabolism];


Pssm-ID: 442357  Cd Length: 99  Bit Score: 144.54  E-value: 1.55e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122300998   6 QVSVAKKANVYFNGKVISRSVVLADGSKQTFGVVLPGEYEFSTAQGEIMQVISGKFDVLLPGKTEWVAYAEASQFELAPN 85
Cdd:COG3123    4 NVTVMKKANVYFDGKVKSRTFIFADGSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWQTYAAGESFEVPAN 83

                         90
                 ....*....|....*.
gi 122300998  86 VSFSIRTDQISEYCCQ 101
Cdd:COG3123   84 SSFDLKVAEPTAYLCS 99
cupin_PpnP-like cd20296
pyrimidine/purine nucleoside phosphorylase and related proteins, cupin domain; This family ...
 13-102 2.85e-40

pyrimidine/purine nucleoside phosphorylase and related proteins, cupin domain; This family includes cupin domain proteins that are homologous to pyrimidine/purine nucleoside phosphorylase PpnP. Purine and pyrimidine nucleoside phosphorylases are key enzymes of the nucleoside salvage pathway; they catalyze the reversible phosphorolytic cleavage of the glycosidic bond of purine and pyrimidine nucleosides. Nucleoside phosphorylases are of medical interest since phosphorylases can be used in activating prodrugs; high-molecular mass purine nucleoside phosphorylases may be used in gene therapy of some solid tumors and their inhibitors could be selective immunosuppressive, anticancer, and antiparasitic agents. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380430  Cd Length: 90  Bit Score: 128.46  E-value: 2.85e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122300998  13 ANVYFNGKVISRSVVLADGSKQTFGVVLPGEYEFSTAQGEIMQVISGKFDVLLPGKTEWVAYAEASQFELAPNVSFSIRT 92
Cdd:cd20296    1 ANVYFDGKVKSRTVIFADGSKKTLGVMLPGEYTFGTEAPERMEIISGECRVKLPGETDWQTYSAGESFEVPANSSFKIEV 80

                         90
                 ....*....|
gi 122300998  93 DQISEYCCQY 102
Cdd:cd20296   81 KEVTDYLCSY 90
PRK10579 PRK10579
pyrimidine/purine nucleoside phosphorylase;
12-103 3.16e-18

pyrimidine/purine nucleoside phosphorylase;


Pssm-ID: 182565  Cd Length: 94  Bit Score: 72.52  E-value: 3.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122300998  12 KANVYFNGKVISRSVVLADGSKQTFGVVLPGEYEFSTAQGEIMQVISGKFDVLLPGKTEWVAYAEASQFELAPNVSFSIR 91
Cdd:PRK10579   3 QSNEYFSGKVKSIGFDSSSTGRASVGVMAEGEYTFSTAEPEEMTVISGALNVLLPGATDWQVYEAGEVFNVPGHSEFHLQ 82

                         90
                 ....*....|..
gi 122300998  92 TDQISEYCCQYI 103
Cdd:PRK10579  83 VAEPTSYLCRYL 94
 
Name Accession Description Interval E-value
Ppnp pfam06865
Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. ...
 11-102 1.39e-49

Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. YaiE from E. coli catalyzes phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and free bases.


Pssm-ID: 462023  Cd Length: 92  Bit Score: 151.87  E-value: 1.39e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122300998   11 KKANVYFNGKVISRSVVLADGSKQTFGVVLPGEYEFSTAQGEIMQVISGKFDVLLPGKTEWVAYAEASQFELAPNVSFSI 90
Cdd:pfam06865   1 KKANVYFDGKVTSRTFEFADGSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWKTYAAGESFEVPANSSFDL 80

                          90
                  ....*....|..
gi 122300998   91 RTDQISEYCCQY 102
Cdd:pfam06865  81 KVKEVTDYLCSY 92
PpnP COG3123
Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide ...
 6-101 1.55e-46

Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide transport and metabolism];


Pssm-ID: 442357  Cd Length: 99  Bit Score: 144.54  E-value: 1.55e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122300998   6 QVSVAKKANVYFNGKVISRSVVLADGSKQTFGVVLPGEYEFSTAQGEIMQVISGKFDVLLPGKTEWVAYAEASQFELAPN 85
Cdd:COG3123    4 NVTVMKKANVYFDGKVKSRTFIFADGSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWQTYAAGESFEVPAN 83

                         90
                 ....*....|....*.
gi 122300998  86 VSFSIRTDQISEYCCQ 101
Cdd:COG3123   84 SSFDLKVAEPTAYLCS 99
cupin_PpnP-like cd20296
pyrimidine/purine nucleoside phosphorylase and related proteins, cupin domain; This family ...
 13-102 2.85e-40

pyrimidine/purine nucleoside phosphorylase and related proteins, cupin domain; This family includes cupin domain proteins that are homologous to pyrimidine/purine nucleoside phosphorylase PpnP. Purine and pyrimidine nucleoside phosphorylases are key enzymes of the nucleoside salvage pathway; they catalyze the reversible phosphorolytic cleavage of the glycosidic bond of purine and pyrimidine nucleosides. Nucleoside phosphorylases are of medical interest since phosphorylases can be used in activating prodrugs; high-molecular mass purine nucleoside phosphorylases may be used in gene therapy of some solid tumors and their inhibitors could be selective immunosuppressive, anticancer, and antiparasitic agents. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380430  Cd Length: 90  Bit Score: 128.46  E-value: 2.85e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122300998  13 ANVYFNGKVISRSVVLADGSKQTFGVVLPGEYEFSTAQGEIMQVISGKFDVLLPGKTEWVAYAEASQFELAPNVSFSIRT 92
Cdd:cd20296    1 ANVYFDGKVKSRTVIFADGSKKTLGVMLPGEYTFGTEAPERMEIISGECRVKLPGETDWQTYSAGESFEVPANSSFKIEV 80

                         90
                 ....*....|
gi 122300998  93 DQISEYCCQY 102
Cdd:cd20296   81 KEVTDYLCSY 90
PRK10579 PRK10579
pyrimidine/purine nucleoside phosphorylase;
12-103 3.16e-18

pyrimidine/purine nucleoside phosphorylase;


Pssm-ID: 182565  Cd Length: 94  Bit Score: 72.52  E-value: 3.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122300998  12 KANVYFNGKVISRSVVLADGSKQTFGVVLPGEYEFSTAQGEIMQVISGKFDVLLPGKTEWVAYAEASQFELAPNVSFSIR 91
Cdd:PRK10579   3 QSNEYFSGKVKSIGFDSSSTGRASVGVMAEGEYTFSTAEPEEMTVISGALNVLLPGATDWQVYEAGEVFNVPGHSEFHLQ 82

                         90
                 ....*....|..
gi 122300998  92 TDQISEYCCQYI 103
Cdd:PRK10579  83 VAEPTSYLCRYL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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