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Conserved domains on  [gi|464759|sp|Q04807|]
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RecName: Full=Glycosylation-dependent cell adhesion molecule 1; Short=GlyCAM-1; AltName: Full=Endothelial ligand FOR L-selectin; AltName: Full=SGP50; AltName: Full=Sulfated 50 kDa glycoprotein; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GLYCAM-1 super family cl05008
Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1); This family consists of the ...
 20-146 1.09e-32

Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1); This family consists of the lactophorin precursors proteose peptone component 3 (PP3) and glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1). GlyCAM-1 functions as a ligand for L-selectin, a saccharide-binding protein on the surface of circulating leukocytes, and mediates the trafficking of blood-born lymphocytes into secondary lymph nodes. In this context, sulphatation of the carbohydrates of GlyCAM-1 has been shown to be a critical structural requirement to be recognized by L-selectin. GlyCAM-1 is also expressed in pregnant and lactating mammary glands of mouse and in an unknown site in the lung, in the bovine uterus and rat cochlea.


The actual alignment was detected with superfamily member pfam05242:

Pssm-ID: 368355  Cd Length: 135  Bit Score: 112.49  E-value: 1.09e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464759      20 VPGSKDELHLRTQPTDAipASQFTPSshisKESTSSKDLSKESFIFNEELVSED-NVGTESTKPQSQE--------AQDG 90
Cdd:pfam05242   1 LPESEDETHMETQPTDA--AAQSITS----EESTSSEDLSKEPSISREELISKEeNVIISSRKPENQElqqlqpipAEDG 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 464759      91 LRSGSSQQEETT-----SAATSEGKLTMLSQAVQKELGKVIEGFISGVEDIISGASGTVRP 146
Cdd:pfam05242  75 LRNASSQSEETTeptpsAATTSEGKLTKLGHTIEKNLGKTIKEFVTYLKSLIPGASEVTKP 135
 
Name Accession Description Interval E-value
GLYCAM-1 pfam05242
Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1); This family consists of the ...
 20-146 1.09e-32

Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1); This family consists of the lactophorin precursors proteose peptone component 3 (PP3) and glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1). GlyCAM-1 functions as a ligand for L-selectin, a saccharide-binding protein on the surface of circulating leukocytes, and mediates the trafficking of blood-born lymphocytes into secondary lymph nodes. In this context, sulphatation of the carbohydrates of GlyCAM-1 has been shown to be a critical structural requirement to be recognized by L-selectin. GlyCAM-1 is also expressed in pregnant and lactating mammary glands of mouse and in an unknown site in the lung, in the bovine uterus and rat cochlea.


Pssm-ID: 368355  Cd Length: 135  Bit Score: 112.49  E-value: 1.09e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464759      20 VPGSKDELHLRTQPTDAipASQFTPSshisKESTSSKDLSKESFIFNEELVSED-NVGTESTKPQSQE--------AQDG 90
Cdd:pfam05242   1 LPESEDETHMETQPTDA--AAQSITS----EESTSSEDLSKEPSISREELISKEeNVIISSRKPENQElqqlqpipAEDG 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 464759      91 LRSGSSQQEETT-----SAATSEGKLTMLSQAVQKELGKVIEGFISGVEDIISGASGTVRP 146
Cdd:pfam05242  75 LRNASSQSEETTeptpsAATTSEGKLTKLGHTIEKNLGKTIKEFVTYLKSLIPGASEVTKP 135
 
Name Accession Description Interval E-value
GLYCAM-1 pfam05242
Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1); This family consists of the ...
 20-146 1.09e-32

Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1); This family consists of the lactophorin precursors proteose peptone component 3 (PP3) and glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1). GlyCAM-1 functions as a ligand for L-selectin, a saccharide-binding protein on the surface of circulating leukocytes, and mediates the trafficking of blood-born lymphocytes into secondary lymph nodes. In this context, sulphatation of the carbohydrates of GlyCAM-1 has been shown to be a critical structural requirement to be recognized by L-selectin. GlyCAM-1 is also expressed in pregnant and lactating mammary glands of mouse and in an unknown site in the lung, in the bovine uterus and rat cochlea.


Pssm-ID: 368355  Cd Length: 135  Bit Score: 112.49  E-value: 1.09e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 464759      20 VPGSKDELHLRTQPTDAipASQFTPSshisKESTSSKDLSKESFIFNEELVSED-NVGTESTKPQSQE--------AQDG 90
Cdd:pfam05242   1 LPESEDETHMETQPTDA--AAQSITS----EESTSSEDLSKEPSISREELISKEeNVIISSRKPENQElqqlqpipAEDG 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 464759      91 LRSGSSQQEETT-----SAATSEGKLTMLSQAVQKELGKVIEGFISGVEDIISGASGTVRP 146
Cdd:pfam05242  75 LRNASSQSEETTeptpsAATTSEGKLTKLGHTIEKNLGKTIKEFVTYLKSLIPGASEVTKP 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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