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Conserved domains on  [gi|401176|sp|Q00918|]
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RecName: Full=Latent-transforming growth factor beta-binding protein 1; Short=LTBP-1; AltName: Full=Transforming growth factor beta-1-binding protein 1; Short=TGF-beta-1-BP-1; AltName: Full=Transforming growth factor beta-1-masking protein large subunit; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 680-721 2.26e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 65.76  E-value: 2.26e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 401176      680 QCMHPLSVHLTKQICCC-SVGKAWGPQCEKCPLPGTAAFKEIC 721
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1350-1392 3.53e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 59.60  E-value: 3.53e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 401176     1350 CDNVLAPNVTKQECCCTS-GAGWGDNCEifPCPVQGTAEFSEMC 1392
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1526-1568 1.80e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.59  E-value: 1.80e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 401176     1526 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPMKDSDDYAQLC 1568
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1194-1235 1.28e-08

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.25  E-value: 1.28e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 401176      1194 DINECAQPGLCAPHGECLNTQGSFHCVCEQGFSisaDGRTCE 1235
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1112-1152 2.57e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 2.57e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 401176      1112 DIDECEHRHLCSHG-QCRNTEGSFQCLCNQGYRAsvlGDHCE 1152
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1071-1102 1.14e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.14e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 401176      1071 DIDECQQGNLCMNG-QCKNTDGSFRCTCGQGYQ 1102
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1236-1277 3.56e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.56e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 401176      1236 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFqapQDGQGCV 1277
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
618-648 7.21e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 7.21e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 401176       618 DINECQLQGVCPNG-ECLNTMGSYRCSCKMGF 648
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
907-948 1.27e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.27e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 401176       907 DIDECAQAqHLCSQG-RCENTEGSFLCICPAGFiasEEGSNCI 948
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1030-1070 1.60e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.60e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 401176      1030 DVDECLQPKVCTNGS-CTNLEGSYMCSCHKGYSptpDHRHCQ 1070
Cdd:smart00179    1 DIDECASGNPCQNGGtCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1153-1183 2.66e-05

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 2.66e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 401176     1153 DINECLEDSSVC-QGGDCINTAGSYDCTCPDG 1183
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1653-1687 5.78e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 5.78e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 401176      1653 DVNECSELNNrmslCKN-AKCINTEGSYKCVCLPGY 1687
Cdd:smart00179    1 DIDECASGNP----CQNgGTCVNTVGSYRCECPPGY 32
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 703-860 8.01e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 8.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401176     703 GPQCEKCPLPGTAAfkeicPGGmgytvsGIHRRRPIHQHIGKEAVFVKPKNTQ----PVAKSTH----PPPLPAKEEPVE 774
Cdd:PHA03247 2844 GPPPPSLPLGGSVA-----PGG------DVRRRPPSRSPAAKPAAPARPPVRRlarpAVSRSTEsfalPPDQPERPPQPQ 2912

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401176     775 ALTSSREHGPGVAEPEVVTAPPEKEIPSLDQEKTRLEPGQPQLSPGVSTI---HLHP-QFPVVVEKTSPPVPVEVAPEGS 850
Cdd:PHA03247 2913 APPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPwlgALVPgRVAVPRFRVPQPAPSREAPASS 2992

                         170
                  ....*....|
gi 401176     851 TSSASQVIAP 860
Cdd:PHA03247 2993 TPPLTGHSLS 3002
EGF_CA smart00179
Calcium-binding EGF-like domain;
949-989 7.82e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 7.82e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 401176       949 DVDECLRPDVCRDG-RCINTAGAFRCEyCDSGYRMSRrgHCE 989
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGYTDGR--NCE 39
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 559-594 1.38e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 38.03  E-value: 1.38e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 401176      559 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKQS 594
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 990-1023 1.92e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.92e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 401176    990 DIDECLTPSTCPEE-QCVNSPGSYQCVpCTEGFRG 1023
Cdd:cd00054    1 DIDECASGNPCQNGgTCVNTVGSYRCS-CPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
1458-1484 5.18e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 5.18e-03
                            10        20
                    ....*....|....*....|....*...
gi 401176      1458 DMDECQDPNSCIDG-QCVNTEGSYNCFC 1484
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCEC 28
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 680-721 2.26e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 65.76  E-value: 2.26e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 401176      680 QCMHPLSVHLTKQICCC-SVGKAWGPQCEKCPLPGTAAFKEIC 721
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1350-1392 3.53e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 59.60  E-value: 3.53e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 401176     1350 CDNVLAPNVTKQECCCTS-GAGWGDNCEifPCPVQGTAEFSEMC 1392
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1526-1568 1.80e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.59  E-value: 1.80e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 401176     1526 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPMKDSDDYAQLC 1568
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1194-1235 1.28e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.25  E-value: 1.28e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 401176      1194 DINECAQPGLCAPHGECLNTQGSFHCVCEQGFSisaDGRTCE 1235
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1194-1235 8.88e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 8.88e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 401176   1194 DINECAQPGLCAPHGECLNTQGSFHCVCEQGFSisadGRTCE 1235
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1112-1152 2.57e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 2.57e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 401176      1112 DIDECEHRHLCSHG-QCRNTEGSFQCLCNQGYRAsvlGDHCE 1152
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1112-1152 1.09e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.09e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 401176   1112 DIDECEHRHLCS-HGQCRNTEGSFQCLCNQGYRasvlGDHCE 1152
Cdd:cd00054    1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1071-1102 1.14e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.14e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 401176      1071 DIDECQQGNLCMNG-QCKNTDGSFRCTCGQGYQ 1102
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1071-1103 2.06e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.06e-06
                         10        20        30
                 ....*....|....*....|....*....|....
gi 401176   1071 DIDECQQGNLCMN-GQCKNTDGSFRCTCGQGYQL 1103
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
1236-1277 3.56e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.56e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 401176      1236 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFqapQDGQGCV 1277
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
618-648 7.21e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 7.21e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 401176       618 DINECQLQGVCPNG-ECLNTMGSYRCSCKMGF 648
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
907-948 1.27e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.27e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 401176       907 DIDECAQAqHLCSQG-RCENTEGSFLCICPAGFiasEEGSNCI 948
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1236-1268 1.36e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.36e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 401176   1236 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQ 1268
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
907-937 1.44e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 43.38  E-value: 1.44e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 401176      907 DIDECAQAQHLCSQ-GRCENTEGSFLCICPAG 937
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1030-1070 1.60e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.60e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 401176      1030 DVDECLQPKVCTNGS-CTNLEGSYMCSCHKGYSptpDHRHCQ 1070
Cdd:smart00179    1 DIDECASGNPCQNGGtCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1153-1183 2.66e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 2.66e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 401176     1153 DINECLEDSSVC-QGGDCINTAGSYDCTCPDG 1183
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 618-648 4.28e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 4.28e-05
                         10        20        30
                 ....*....|....*....|....*....|..
gi 401176    618 DINECQLQGVCPN-GECLNTMGSYRCSCKMGF 648
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1653-1687 5.78e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 5.78e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 401176      1653 DVNECSELNNrmslCKN-AKCINTEGSYKCVCLPGY 1687
Cdd:smart00179    1 DIDECASGNP----CQNgGTCVNTVGSYRCECPPGY 32
PHA03247 PHA03247
large tegument protein UL36; Provisional
 703-860 8.01e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 8.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401176     703 GPQCEKCPLPGTAAfkeicPGGmgytvsGIHRRRPIHQHIGKEAVFVKPKNTQ----PVAKSTH----PPPLPAKEEPVE 774
Cdd:PHA03247 2844 GPPPPSLPLGGSVA-----PGG------DVRRRPPSRSPAAKPAAPARPPVRRlarpAVSRSTEsfalPPDQPERPPQPQ 2912

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401176     775 ALTSSREHGPGVAEPEVVTAPPEKEIPSLDQEKTRLEPGQPQLSPGVSTI---HLHP-QFPVVVEKTSPPVPVEVAPEGS 850
Cdd:PHA03247 2913 APPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPwlgALVPgRVAVPRFRVPQPAPSREAPASS 2992

                         170
                  ....*....|
gi 401176     851 TSSASQVIAP 860
Cdd:PHA03247 2993 TPPLTGHSLS 3002
EGF_CA pfam07645
Calcium-binding EGF domain;
1194-1224 8.48e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.07  E-value: 8.48e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 401176     1194 DINECAQPG-LCAPHGECLNTQGSFHCVCEQG 1224
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1153-1183 1.50e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.50e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 401176      1153 DINECLEDSSVCQGGDCINTAGSYDCTCPDG 1183
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 907-948 1.63e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.63e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 401176    907 DIDECAQAqHLCS-QGRCENTEGSFLCICPAGFiaseEGSNCI 948
Cdd:cd00054    1 DIDECASG-NPCQnGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1653-1687 1.85e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.85e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 401176   1653 DVNECSELNNrmslCKN-AKCINTEGSYKCVCLPGY 1687
Cdd:cd00054    1 DIDECASGNP----CQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1030-1070 3.18e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 3.18e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 401176   1030 DVDECLQPKVCTN-GSCTNLEGSYMCSCHKGYSPtpdhRHCQ 1070
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG----RNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
949-989 7.82e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 7.82e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 401176       949 DVDECLRPDVCRDG-RCINTAGAFRCEyCDSGYRMSRrgHCE 989
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGYTDGR--NCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1153-1183 9.19e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 9.19e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 401176   1153 DINECLEDSSVCQGGDCINTAGSYDCTCPDG 1183
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPG 31
EGF_CA pfam07645
Calcium-binding EGF domain;
1236-1266 1.28e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.28e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 401176     1236 DIDECVNNT-VCDSHGFCDNTAGSFRCLCYQG 1266
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 559-594 1.38e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 38.03  E-value: 1.38e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 401176      559 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKQS 594
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37
EGF_CA pfam07645
Calcium-binding EGF domain;
618-647 1.57e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.57e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 401176      618 DINEC-QLQGVCP-NGECLNTMGSYRCSCKMG 647
Cdd:pfam07645    1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 990-1023 1.92e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.92e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 401176    990 DIDECLTPSTCPEE-QCVNSPGSYQCVpCTEGFRG 1023
Cdd:cd00054    1 DIDECASGNPCQNGgTCVNTVGSYRCS-CPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
1653-1686 2.09e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 2.09e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 401176     1653 DVNECSELNNrmsLC-KNAKCINTEGSYKCVCLPG 1686
Cdd:pfam07645    1 DVDECATGTH---NCpANTVCVNTIGSFECRCPDG 32
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 1054-1074 3.01e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 36.62  E-value: 3.01e-03
                           10        20
                   ....*....|....*....|.
gi 401176     1054 CSCHKGYSPTPDHRHCQDIDE 1074
Cdd:pfam12662    2 CSCPPGYQLDPDGRTCVDIDE 22
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 949-989 3.95e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.95e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 401176    949 DVDECLRPDVCR-DGRCINTAGAFRCEyCDSGYRMsrrGHCE 989
Cdd:cd00054    1 DIDECASGNPCQnGGTCVNTVGSYRCS-CPPGYTG---RNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
990-1022 4.56e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 4.56e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 401176       990 DIDECLTPSTC-PEEQCVNSPGSYQCVpCTEGFR 1022
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1458-1484 5.18e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 5.18e-03
                            10        20
                    ....*....|....*....|....*...
gi 401176      1458 DMDECQDPNSCIDG-QCVNTEGSYNCFC 1484
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCEC 28
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1458-1484 6.33e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 6.33e-03
                         10        20
                 ....*....|....*....|....*...
gi 401176   1458 DMDECQDPNSC-IDGQCVNTEGSYNCFC 1484
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCSC 28
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 680-721 2.26e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 65.76  E-value: 2.26e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 401176      680 QCMHPLSVHLTKQICCC-SVGKAWGPQCEKCPLPGTAAFKEIC 721
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1350-1392 3.53e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 59.60  E-value: 3.53e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 401176     1350 CDNVLAPNVTKQECCCTS-GAGWGDNCEifPCPVQGTAEFSEMC 1392
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSvGRAWGSPCE--LCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1526-1568 1.80e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.59  E-value: 1.80e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 401176     1526 VCSRPLVGkQTTYTECCCLY-GEAWGMQCALCPMKDSDDYAQLC 1568
Cdd:pfam00683    2 RCSNPLPG-NVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1194-1235 1.28e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.25  E-value: 1.28e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 401176      1194 DINECAQPGLCAPHGECLNTQGSFHCVCEQGFSisaDGRTCE 1235
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1194-1235 8.88e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 8.88e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 401176   1194 DINECAQPGLCAPHGECLNTQGSFHCVCEQGFSisadGRTCE 1235
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1112-1152 2.57e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 2.57e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 401176      1112 DIDECEHRHLCSHG-QCRNTEGSFQCLCNQGYRAsvlGDHCE 1152
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1112-1152 1.09e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.09e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 401176   1112 DIDECEHRHLCS-HGQCRNTEGSFQCLCNQGYRasvlGDHCE 1152
Cdd:cd00054    1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1071-1102 1.14e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.14e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 401176      1071 DIDECQQGNLCMNG-QCKNTDGSFRCTCGQGYQ 1102
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1071-1103 2.06e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.06e-06
                         10        20        30
                 ....*....|....*....|....*....|....
gi 401176   1071 DIDECQQGNLCMN-GQCKNTDGSFRCTCGQGYQL 1103
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
1236-1277 3.56e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.56e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 401176      1236 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFqapQDGQGCV 1277
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
618-648 7.21e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 7.21e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 401176       618 DINECQLQGVCPNG-ECLNTMGSYRCSCKMGF 648
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
907-948 1.27e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.27e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 401176       907 DIDECAQAqHLCSQG-RCENTEGSFLCICPAGFiasEEGSNCI 948
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1236-1268 1.36e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.36e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 401176   1236 DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQ 1268
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
907-937 1.44e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 43.38  E-value: 1.44e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 401176      907 DIDECAQAQHLCSQ-GRCENTEGSFLCICPAG 937
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1030-1070 1.60e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.60e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 401176      1030 DVDECLQPKVCTNGS-CTNLEGSYMCSCHKGYSptpDHRHCQ 1070
Cdd:smart00179    1 DIDECASGNPCQNGGtCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1153-1183 2.66e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 2.66e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 401176     1153 DINECLEDSSVC-QGGDCINTAGSYDCTCPDG 1183
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 618-648 4.28e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 4.28e-05
                         10        20        30
                 ....*....|....*....|....*....|..
gi 401176    618 DINECQLQGVCPN-GECLNTMGSYRCSCKMGF 648
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1653-1687 5.78e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 5.78e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 401176      1653 DVNECSELNNrmslCKN-AKCINTEGSYKCVCLPGY 1687
Cdd:smart00179    1 DIDECASGNP----CQNgGTCVNTVGSYRCECPPGY 32
PHA03247 PHA03247
large tegument protein UL36; Provisional
 703-860 8.01e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 8.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401176     703 GPQCEKCPLPGTAAfkeicPGGmgytvsGIHRRRPIHQHIGKEAVFVKPKNTQ----PVAKSTH----PPPLPAKEEPVE 774
Cdd:PHA03247 2844 GPPPPSLPLGGSVA-----PGG------DVRRRPPSRSPAAKPAAPARPPVRRlarpAVSRSTEsfalPPDQPERPPQPQ 2912

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 401176     775 ALTSSREHGPGVAEPEVVTAPPEKEIPSLDQEKTRLEPGQPQLSPGVSTI---HLHP-QFPVVVEKTSPPVPVEVAPEGS 850
Cdd:PHA03247 2913 APPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPwlgALVPgRVAVPRFRVPQPAPSREAPASS 2992

                         170
                  ....*....|
gi 401176     851 TSSASQVIAP 860
Cdd:PHA03247 2993 TPPLTGHSLS 3002
EGF_CA pfam07645
Calcium-binding EGF domain;
1194-1224 8.48e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.07  E-value: 8.48e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 401176     1194 DINECAQPG-LCAPHGECLNTQGSFHCVCEQG 1224
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1153-1183 1.50e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.50e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 401176      1153 DINECLEDSSVCQGGDCINTAGSYDCTCPDG 1183
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 907-948 1.63e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.63e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 401176    907 DIDECAQAqHLCS-QGRCENTEGSFLCICPAGFiaseEGSNCI 948
Cdd:cd00054    1 DIDECASG-NPCQnGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1653-1687 1.85e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.85e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 401176   1653 DVNECSELNNrmslCKN-AKCINTEGSYKCVCLPGY 1687
Cdd:cd00054    1 DIDECASGNP----CQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1030-1070 3.18e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 3.18e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 401176   1030 DVDECLQPKVCTN-GSCTNLEGSYMCSCHKGYSPtpdhRHCQ 1070
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG----RNCE 38
EGF smart00181
Epidermal growth factor-like domain;
1074-1104 7.17e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 38.65  E-value: 7.17e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 401176      1074 ECQQGNLCMNGQCKNTDGSFRCTCGQGYQLS 1104
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGD 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
949-989 7.82e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 7.82e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 401176       949 DVDECLRPDVCRDG-RCINTAGAFRCEyCDSGYRMSRrgHCE 989
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGYTDGR--NCE 39
EGF smart00181
Epidermal growth factor-like domain;
621-653 8.56e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 38.27  E-value: 8.56e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 401176       621 ECQLQGVCPNGECLNTMGSYRCSCKMGFGPDPT 653
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF smart00181
Epidermal growth factor-like domain;
1115-1143 8.64e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 38.27  E-value: 8.64e-04
                            10        20
                    ....*....|....*....|....*....
gi 401176      1115 ECEHRHLCSHGQCRNTEGSFQCLCNQGYR 1143
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYT 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1153-1183 9.19e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 9.19e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 401176   1153 DINECLEDSSVCQGGDCINTAGSYDCTCPDG 1183
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPG 31
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 901-944 1.20e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 42.37  E-value: 1.20e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 401176    901 QQRKCIDIDECAQAQHLCSQGrCENTEGSFLCICPAGFIASEEG 944
Cdd:cd01475  180 QGKICVVPDLCATLSHVCQQV-CISTPGSYLCACTEGYALLEDN 222
EGF_CA pfam07645
Calcium-binding EGF domain;
1236-1266 1.28e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.28e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 401176     1236 DIDECVNNT-VCDSHGFCDNTAGSFRCLCYQG 1266
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 559-594 1.38e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 38.03  E-value: 1.38e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 401176      559 QCGKALPG-LSKQEDCCGTVGTSWGfNKCQKCPKKQS 594
Cdd:pfam00683    2 RCSNPLPGnVTKSECCCTSVGRAWG-SPCELCPPPGT 37
EGF_CA pfam07645
Calcium-binding EGF domain;
618-647 1.57e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.57e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 401176      618 DINEC-QLQGVCP-NGECLNTMGSYRCSCKMG 647
Cdd:pfam07645    1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 990-1023 1.92e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.92e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 401176    990 DIDECLTPSTCPEE-QCVNSPGSYQCVpCTEGFRG 1023
Cdd:cd00054    1 DIDECASGNPCQNGgTCVNTVGSYRCS-CPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
1653-1686 2.09e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 2.09e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 401176     1653 DVNECSELNNrmsLC-KNAKCINTEGSYKCVCLPG 1686
Cdd:pfam07645    1 DVDECATGTH---NCpANTVCVNTIGSFECRCPDG 32
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 1218-1239 2.90e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 36.62  E-value: 2.90e-03
                           10        20
                   ....*....|....*....|..
gi 401176     1218 HCVCEQGFSISADGRTCEDIDE 1239
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1197-1226 2.90e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 2.90e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 401176   1197 ECAQPGLCAPHGECLNTQGSFHCVCEQGFS 1226
Cdd:cd00053    1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYT 30
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 1054-1074 3.01e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 36.62  E-value: 3.01e-03
                           10        20
                   ....*....|....*....|.
gi 401176     1054 CSCHKGYSPTPDHRHCQDIDE 1074
Cdd:pfam12662    2 CSCPPGYQLDPDGRTCVDIDE 22
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 949-989 3.95e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.95e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 401176    949 DVDECLRPDVCR-DGRCINTAGAFRCEyCDSGYRMsrrGHCE 989
Cdd:cd00054    1 DIDECASGNPCQnGGTCVNTVGSYRCS-CPPGYTG---RNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
990-1022 4.56e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 4.56e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 401176       990 DIDECLTPSTC-PEEQCVNSPGSYQCVpCTEGFR 1022
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1458-1484 5.18e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 5.18e-03
                            10        20
                    ....*....|....*....|....*...
gi 401176      1458 DMDECQDPNSCIDG-QCVNTEGSYNCFC 1484
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCEC 28
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1458-1484 6.33e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 6.33e-03
                         10        20
                 ....*....|....*....|....*...
gi 401176   1458 DMDECQDPNSC-IDGQCVNTEGSYNCFC 1484
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCSC 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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