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Conserved domains on  [gi|1401022201|gb|PYT92231|]
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hypothetical protein DMG41_00095, partial [Acidobacteria bacterium]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 3-194 3.64e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 74.77  E-value: 3.64e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201   3 LGEAFAIAGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRQTRTQWAAVLARLHRYK 82
Cdd:COG2956    48 LGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWE 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201  83 GAESALAGLppPSSREERIAFYRLKGSVALGLGNPSAAAAEMEKALLLKPNDVGLNVATAAAEVHSNNWQRAARLVGPAY 162
Cdd:COG2956   128 KAIEVLERL--LKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERAL 205

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1401022201 163 SLNHDPGIGLVLLEAQLGGSDDVKQTLESLRA 194
Cdd:COG2956   206 EQDPDYLPALPRLAELYEKLGDPEEALELLRK 237
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 3-194 3.64e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 74.77  E-value: 3.64e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201   3 LGEAFAIAGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRQTRTQWAAVLARLHRYK 82
Cdd:COG2956    48 LGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWE 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201  83 GAESALAGLppPSSREERIAFYRLKGSVALGLGNPSAAAAEMEKALLLKPNDVGLNVATAAAEVHSNNWQRAARLVGPAY 162
Cdd:COG2956   128 KAIEVLERL--LKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERAL 205

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1401022201 163 SLNHDPGIGLVLLEAQLGGSDDVKQTLESLRA 194
Cdd:COG2956   206 EQDPDYLPALPRLAELYEKLGDPEEALELLRK 237
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 4-158 5.30e-06

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 46.23  E-value: 5.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201    4 GEAFAIAGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRqtrtqwAAV--LARLHRY 81
Cdd:PRK11447   358 GDAALKANNLAQAERLYQQARQVDNTDSYAVLGLGDVAMARKDYAAAERYYQQALRMDPGNT------NAVrgLANLYRQ 431

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201   82 KGAESALA---GLPPPSSREER-------IAFYRLKGSVALGLGNPSAAAAEMEKALLLKPNDVGLNVATAAAEVHSNNW 151
Cdd:PRK11447   432 QSPEKALAfiaSLSASQRRSIDdierslqNDRLAQQAEALENQGKWAQAAELQRQRLALDPGSVWLTYRLAQDLRQAGQR 511


                   ....*..
gi 1401022201  152 QRAARLV 158
Cdd:PRK11447   512 SQADALM 518
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 2-194 1.41e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 45.07  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201   2 LLGEAFAIAGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRQTRTQWAAVLARLHRy 81
Cdd:TIGR02917 470 LLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGN- 548

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201  82 kgAESALAGLPPPSSRE-ERIAFYRLKGSVALGLGNPSAAAAEMEKALLLKPNDVGLNVATAAAEVHSNNWQRAARLVGP 160
Cdd:TIGR02917 549 --EEEAVAWLEKAAELNpQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKK 626

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1401022201 161 AYSLNHDPGIGLVLLEAQLGGSDDVKQTLESLRA 194
Cdd:TIGR02917 627 LLALQPDSALALLLLADAYAVMKNYAKAITSLKR 660
TPR_19 pfam14559
Tetratricopeptide repeat;
10-78 1.82e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 35.64  E-value: 1.82e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1401022201  10 AGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKlshgTRQTRTQWAAVLARL 78
Cdd:pfam14559   1 EGDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPA----ADPDDPRYAALLAKL 65
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 3-194 3.64e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 74.77  E-value: 3.64e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201   3 LGEAFAIAGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRQTRTQWAAVLARLHRYK 82
Cdd:COG2956    48 LGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWE 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201  83 GAESALAGLppPSSREERIAFYRLKGSVALGLGNPSAAAAEMEKALLLKPNDVGLNVATAAAEVHSNNWQRAARLVGPAY 162
Cdd:COG2956   128 KAIEVLERL--LKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERAL 205

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1401022201 163 SLNHDPGIGLVLLEAQLGGSDDVKQTLESLRA 194
Cdd:COG2956   206 EQDPDYLPALPRLAELYEKLGDPEEALELLRK 237
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1-192 7.86e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.44  E-value: 7.86e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201   1 MLLGEAFAIAGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRQTRTQWAAVLARLHR 80
Cdd:COG2956    80 LELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGD 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201  81 YKGAESALAGLppPSSREERIAFYRLKGSVALGLGNPSAAAAEMEKALLLKPNDVGLNVATAAAEVHSNNWQRAARLVGP 160
Cdd:COG2956   160 YDEAIEALEKA--LKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRK 237

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1401022201 161 AYSLNHDPGIGLVL--LEAQLGGSDDVKQTLESL 192
Cdd:COG2956   238 ALELDPSDDLLLALadLLERKEGLEAALALLERQ 271
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 2-168 8.55e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.47  E-value: 8.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201   2 LLGEAFAIAGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRQTRTQWAAVLARLHRY 81
Cdd:COG3914    83 LAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRL 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201  82 KGAES----ALAGLPppssreERIAFYRLKGSVALGLGNPSAAAAEMEKALLLKPNDVGLNVATAAAEVHSNNWQRAARL 157
Cdd:COG3914   163 EEAIAalrrALELDP------DNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDRF 236

                         170
                  ....*....|.
gi 1401022201 158 VGPAYSLNHDP 168
Cdd:COG3914   237 EELLAALARGP 247
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
3-205 1.75e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.48  E-value: 1.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201   3 LGEAFAIAGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRQTRTQWAAVLARLHRYK 82
Cdd:COG0457    14 LGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYE 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201  83 GAESALA---GLPPpssreERIAFYRLKGSVALGLGNPSAAAAEMEKALLLKPNDVGLNVATAAAEVHSNNWQRAARLVG 159
Cdd:COG0457    94 EALEDYDkalELDP-----DDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLE 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1401022201 160 PAYSLNHDPGIGLVLLEAQLGGSDDVKQTLESLRATSLPPEETAAL 205
Cdd:COG0457   169 KLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAIL 214
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1-134 2.98e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.97  E-value: 2.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201   1 MLLGEAFAIAGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRQTRTQWAAVLARLHR 80
Cdd:COG4783     8 YALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGD 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1401022201  81 YKGAESALAGLppPSSREERIAFYRLKGSVALGLGNPSAAAAEMEKALLLKPND 134
Cdd:COG4783    88 YDEALALLEKA--LKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1-91 4.06e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 50.00  E-value: 4.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201   1 MLLGEAFAIAGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRQTRTQWAAVLARLHR 80
Cdd:COG4235    21 LLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGD 100

                          90
                  ....*....|.
gi 1401022201  81 YKGAESALAGL 91
Cdd:COG4235   101 YAEAIAAWQKL 111
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
3-162 1.27e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.39  E-value: 1.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201   3 LGEAFAIAGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRQTRTQWAAVLARLHRYK 82
Cdd:COG0457    82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYE 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201  83 GAESALAGLPPPSSREERIAFYRLKGSVALGLGNPSAAAAEMEKALLLKPNDVGLNVATAAAEVHSNNWQRAARLVGPAY 162
Cdd:COG0457   162 EALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALY 241
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 4-158 5.30e-06

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 46.23  E-value: 5.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201    4 GEAFAIAGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRqtrtqwAAV--LARLHRY 81
Cdd:PRK11447   358 GDAALKANNLAQAERLYQQARQVDNTDSYAVLGLGDVAMARKDYAAAERYYQQALRMDPGNT------NAVrgLANLYRQ 431

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201   82 KGAESALA---GLPPPSSREER-------IAFYRLKGSVALGLGNPSAAAAEMEKALLLKPNDVGLNVATAAAEVHSNNW 151
Cdd:PRK11447   432 QSPEKALAfiaSLSASQRRSIDdierslqNDRLAQQAEALENQGKWAQAAELQRQRLALDPGSVWLTYRLAQDLRQAGQR 511


                   ....*..
gi 1401022201  152 QRAARLV 158
Cdd:PRK11447   512 SQADALM 518
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 2-194 1.41e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 45.07  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201   2 LLGEAFAIAGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRQTRTQWAAVLARLHRy 81
Cdd:TIGR02917 470 LLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGN- 548

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201  82 kgAESALAGLPPPSSRE-ERIAFYRLKGSVALGLGNPSAAAAEMEKALLLKPNDVGLNVATAAAEVHSNNWQRAARLVGP 160
Cdd:TIGR02917 549 --EEEAVAWLEKAAELNpQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKK 626

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1401022201 161 AYSLNHDPGIGLVLLEAQLGGSDDVKQTLESLRA 194
Cdd:TIGR02917 627 LLALQPDSALALLLLADAYAVMKNYAKAITSLKR 660
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
24-193 1.56e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.23  E-value: 1.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201  24 LQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRQTRTQWAAVLARLHRYKGA----ESALAGLPppssreE 99
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEAladyEQALELDP------D 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201 100 RIAFYRLKGSVALGLGNPSAAAAEMEKALLLKPNDVGLNVATAAAEVHSNNWQRAARLVGPAYSLNHDPGIGLVLLEAQL 179
Cdd:COG0457    75 DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIAL 154

                         170
                  ....*....|....
gi 1401022201 180 GGSDDVKQTLESLR 193
Cdd:COG0457   155 EKLGRYEEALELLE 168
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 2-135 1.91e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 44.69  E-value: 1.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201   2 LLGEAFAIAGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRQTRTQWAAVLARLHRY 81
Cdd:TIGR02917 368 LLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLDPELGRADLLLILSYLRSGQF 447

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1401022201  82 KGAESALAGLppPSSREERIAFYRLKGSVALGLGNPSAAAAEMEKALLLKPNDV 135
Cdd:TIGR02917 448 DKALAAAKKL--EKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFF 499
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
10-88 2.08e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 41.69  E-value: 2.08e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1401022201  10 AGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPmLARAVKLSHGTRQTRTQWAAVLARLHRYKGAESAL 88
Cdd:COG3063     5 LGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYL 82
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 15-134 2.16e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 42.69  E-value: 2.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201  15 RAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRQTRTQWAAVLARLHRYKGAES----ALAG 90
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEEllerALAL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1401022201  91 LPppssreERIAFYRLKGSVALGLGNPSAAAAEMEKALLLKPND 134
Cdd:COG4235    81 DP------DNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPAD 118
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1-204 5.58e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 5.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201   1 MLLGEAFAIAGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRQTRTQWAAVLARLHR 80
Cdd:TIGR02917 197 LLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALVDFQKKN 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201  81 YKGAESALAGLppPSSREERIAFYRLKGSVALGLGNPSAAAAEMEKALLLKPNDVGLNVATAAAEVHSNNWQRAARLVGP 160
Cdd:TIGR02917 277 YEDARETLQDA--LKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSP 354

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1401022201 161 AYSLN-HDPGIGLVLLEAQLGGSDDVKQTLESLRATSLPPEETAA 204
Cdd:TIGR02917 355 ALGLDpDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAA 399
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 6-89 5.80e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.87  E-value: 5.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201   6 AFAIAGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRQTRTQWAAVLARLHRYKGAE 85
Cdd:COG5010    63 LYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAK 142


                  ....
gi 1401022201  86 SALA 89
Cdd:COG5010   143 AALQ 146
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1-60 8.53e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 42.67  E-value: 8.53e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201   1 MLLGEAFAIAGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKL 60
Cdd:COG3914   150 LNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALEL 209
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 4-157 1.60e-03

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 38.91  E-value: 1.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201    4 GEAFAIAGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRQtRTQWAAVLaRLHRYKG 83
Cdd:PRK11447   276 GLAAVDSGQGGKAIPELQQAVRANPKDSEALGALGQAYSQQGDRARAVAQFEKALALDPHSSN-RDKWESLL-KVNRYWL 353

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201   84 AesalaglpppssreerIAfyrlKGSVALGLGNPSAAAAEMEKALLLKPND----VGL-NVA-----TAAAEVHsnnWQR 153
Cdd:PRK11447   354 L----------------IQ----QGDAALKANNLAQAERLYQQARQVDNTDsyavLGLgDVAmarkdYAAAERY---YQQ 410


                   ....
gi 1401022201  154 AARL 157
Cdd:PRK11447   411 ALRM 414
TPR_19 pfam14559
Tetratricopeptide repeat;
10-78 1.82e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 35.64  E-value: 1.82e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1401022201  10 AGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKlshgTRQTRTQWAAVLARL 78
Cdd:pfam14559   1 EGDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPA----ADPDDPRYAALLAKL 65
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
3-61 1.98e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.30  E-value: 1.98e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1401022201   3 LGEAFAIAGQSDRAEAeFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLS 61
Cdd:COG3063    32 LGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELD 89
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
3-131 6.16e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 36.52  E-value: 6.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201   3 LGEAFAIAGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRQTRTQWAAVLARLHRYK 82
Cdd:COG0457   116 LGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEV 195

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1401022201  83 GAESALAGLPPPSSREERIAFYRLKGSVALGLGNPSAAAAEMEKALLLK 131
Cdd:COG0457   196 LLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQYR 244
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 2-59 8.19e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 34.97  E-value: 8.19e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1401022201   2 LLGEAFAIAGQSDRAEAEFQRVLQITPNNYFALAAL---AGLHDRAGHPEKAEPMLARAVK 59
Cdd:COG1729    35 WLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDALlklGLSYLELGDYDKARATLEELIK 95
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 33-167 8.96e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 35.17  E-value: 8.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201  33 ALAALAGLHDRAGHPEKAEPMLARAVKLSHGTRQTRTQWAAVLARLHRYKGAES----ALAGLPppssreERIAFYRLKG 108
Cdd:COG4783     6 ALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVllheALELDP------DEPEARLNLG 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1401022201 109 SVALGLGNPSAAAAEMEKALLLKPNDVGLNVATAAAEVHSNNWQRAARLVGPAYSLNHD 167
Cdd:COG4783    80 LALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPD 138
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
3-94 9.11e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 36.05  E-value: 9.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401022201   3 LGEAFAIAGQSDRAEAEFQRVLQITPNNYFALAALAGLHDRAGHPEKAEPMLARAVKLsHGTRQTRTQWAAVLARLHRYK 82
Cdd:COG4785   113 RGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALEL-DPNDPERALWLYLAERKLDPE 191

                          90
                  ....*....|..
gi 1401022201  83 GAESALAGLPPP 94
Cdd:COG4785   192 KALALLLEDWAT 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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