|
Name |
Accession |
Description |
Interval |
E-value |
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
18-351 |
2.08e-143 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 411.46 E-value: 2.08e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 18 ILLVDLDAFFASVEQLDHPEWRGKPVIVGGRAdRRGVVSTCSYEARTYGVHSAMASAVAERLCPDAIWTTPHFERYHEMS 97
Cdd:COG0389 3 ILHVDMDAFYASVEQRDRPELRGKPVAVGGDN-NRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 98 RAVMDILYAESPLLEQVSIDEAFLDVTPGRFTGDDPVAIAMRIQEHV-AELGVTCSIGVASGKTVAKIASDLDKPRGLTV 176
Cdd:COG0389 82 RRVMAILERYTPLVEPLSIDEAFLDVTGSARLFGSAEAIARRIRRRIrRETGLTVSVGIAPNKFLAKIASDLAKPDGLTV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 177 VYPGSEATFLAPMKIRVMSGIGKQSVKRLEAVGIRTLGELATADVETLRPIFGVNAPVMRDRAAGIDERPIVTERTLKSV 256
Cdd:COG0389 162 IPPGEVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRPVEPRRPRKSI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 257 SHERTFASDLTTRAEIEDAVDFLGSMVGRRLRRKQLAGHTVTLKLRYADLSIRSAQQGLGANVDDEGVFIPIAKRLIGEI 336
Cdd:COG0389 242 GVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLRAARELLERI 321
|
330
....*....|....*
gi 1391400002 337 WQEGDAVRLVGVGVS 351
Cdd:COG0389 322 YRPGRPVRLLGVRLS 336
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
19-353 |
8.51e-143 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 409.99 E-value: 8.51e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 19 LLVDLDAFFASVEQLDHPEWRGKPVIVGGRADRrGVVSTCSYEARTYGVHSAMASAVAERLCPDAIWTTPHFERYHEMSR 98
Cdd:cd03586 1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSDR-GVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 99 AVMDILYAESPLLEQVSIDEAFLDVTPGRFTGDDPVAIAMRIQEHVA-ELGVTCSIGVASGKTVAKIASDLDKPRGLTVV 177
Cdd:cd03586 80 QIMEILREYTPLVEPLSIDEAYLDVTDYVRLFGSATEIAKEIRARIReETGLTASAGIAPNKFLAKIASDLNKPNGLTVI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 178 YPGSEATFLAPMKIRVMSGIGKQSVKRLEAVGIRTLGELATADVETLRPIFGVNAPVMRDRAAGIDERPIVTERTLKSVS 257
Cdd:cd03586 160 PPEDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 258 HERTFASDLTTRAEIEDAVDFLGSMVGRRLRRKQLAGHTVTLKLRYADLSIRSAQQGLGANVDDEGVFIPIAKRLIGEIW 337
Cdd:cd03586 240 VERTFSEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLEELL 319
|
330
....*....|....*.
gi 1391400002 338 QeGDAVRLVGVGVSGF 353
Cdd:cd03586 320 D-GRPIRLLGVRLSGL 334
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
24-363 |
1.49e-118 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 348.65 E-value: 1.49e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 24 DAFFASVEQLDHPEWRGKPVIVGGRADRRGVVSTCSYEARTYGVHSAMASAVAERLCPDAIWTTPHFERYHEMSRAVMDI 103
Cdd:PRK02406 2 DCFYAAVEMRDNPELRGKPVAVGGSPGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIREI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 104 LYAESPLLEQVSIDEAFLDVTpgrftgDDP------VAIAMRIQEHV-AELGVTCSIGVASGKTVAKIASDLDKPRGLTV 176
Cdd:PRK02406 82 FRRYTDLIEPLSLDEAYLDVT------DNKlcigsaTLIAQEIRQDIfEELGLTASAGVAPNKFLAKIASDWNKPNGLFV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 177 VYPGSEATFLAPMKIRVMSGIGKQSVKRLEAVGIRTLGELATADVETLRPIFGVNAPVMRDRAAGIDERPIVTERTLKSV 256
Cdd:PRK02406 156 ITPEEVDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKFGRRLYERARGIDERPVKPDRERKSV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 257 SHERTFASDLTTRAEIEDAVDFLGSMVGRRLRRKQ--LAGHTVTLKLRYADLSIRSAQQGlganvdDEGVFIPIAKRLIG 334
Cdd:PRK02406 236 GVERTFAEDLYDLEACLAELPRLAEKLERRLERAKpdKRIKTVGVKLKFADFQQTTKEHT------ADPLDKADLIELLA 309
|
330 340 350
....*....|....*....|....*....|...
gi 1391400002 335 EIWQE---GDAVRLVGVGVSGFDTQDE-QLDLF 363
Cdd:PRK02406 310 QALLRrlgGRGVRLLGVGVTLLEPQLErQLLLD 342
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
21-167 |
9.02e-56 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 180.85 E-value: 9.02e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 21 VDLDAFFASVEQLDHPEWRGKPVIVGGrADRRGVVSTCSYEARTYGVHSAMASAVAERLCPDAIWTTPHFERYHEMSRAV 100
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGG-GNGRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKI 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1391400002 101 MDILYA-ESPLLEQVSIDEAFLDVTPGRFTGDDPVAIAMRIQEHVA-ELGVTCSIGVASGKTVAKIASD 167
Cdd:pfam00817 80 FEILRRfSTPKVEQASIDEAFLDLTGLEKLFGAEEALAKRLRREIAeETGLTCSIGIAPNKLLAKLASD 148
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
18-351 |
2.08e-143 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 411.46 E-value: 2.08e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 18 ILLVDLDAFFASVEQLDHPEWRGKPVIVGGRAdRRGVVSTCSYEARTYGVHSAMASAVAERLCPDAIWTTPHFERYHEMS 97
Cdd:COG0389 3 ILHVDMDAFYASVEQRDRPELRGKPVAVGGDN-NRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 98 RAVMDILYAESPLLEQVSIDEAFLDVTPGRFTGDDPVAIAMRIQEHV-AELGVTCSIGVASGKTVAKIASDLDKPRGLTV 176
Cdd:COG0389 82 RRVMAILERYTPLVEPLSIDEAFLDVTGSARLFGSAEAIARRIRRRIrRETGLTVSVGIAPNKFLAKIASDLAKPDGLTV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 177 VYPGSEATFLAPMKIRVMSGIGKQSVKRLEAVGIRTLGELATADVETLRPIFGVNAPVMRDRAAGIDERPIVTERTLKSV 256
Cdd:COG0389 162 IPPGEVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRPVEPRRPRKSI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 257 SHERTFASDLTTRAEIEDAVDFLGSMVGRRLRRKQLAGHTVTLKLRYADLSIRSAQQGLGANVDDEGVFIPIAKRLIGEI 336
Cdd:COG0389 242 GVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLRAARELLERI 321
|
330
....*....|....*
gi 1391400002 337 WQEGDAVRLVGVGVS 351
Cdd:COG0389 322 YRPGRPVRLLGVRLS 336
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
19-353 |
8.51e-143 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 409.99 E-value: 8.51e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 19 LLVDLDAFFASVEQLDHPEWRGKPVIVGGRADRrGVVSTCSYEARTYGVHSAMASAVAERLCPDAIWTTPHFERYHEMSR 98
Cdd:cd03586 1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSDR-GVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 99 AVMDILYAESPLLEQVSIDEAFLDVTPGRFTGDDPVAIAMRIQEHVA-ELGVTCSIGVASGKTVAKIASDLDKPRGLTVV 177
Cdd:cd03586 80 QIMEILREYTPLVEPLSIDEAYLDVTDYVRLFGSATEIAKEIRARIReETGLTASAGIAPNKFLAKIASDLNKPNGLTVI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 178 YPGSEATFLAPMKIRVMSGIGKQSVKRLEAVGIRTLGELATADVETLRPIFGVNAPVMRDRAAGIDERPIVTERTLKSVS 257
Cdd:cd03586 160 PPEDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 258 HERTFASDLTTRAEIEDAVDFLGSMVGRRLRRKQLAGHTVTLKLRYADLSIRSAQQGLGANVDDEGVFIPIAKRLIGEIW 337
Cdd:cd03586 240 VERTFSEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLEELL 319
|
330
....*....|....*.
gi 1391400002 338 QeGDAVRLVGVGVSGF 353
Cdd:cd03586 320 D-GRPIRLLGVRLSGL 334
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
24-363 |
1.49e-118 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 348.65 E-value: 1.49e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 24 DAFFASVEQLDHPEWRGKPVIVGGRADRRGVVSTCSYEARTYGVHSAMASAVAERLCPDAIWTTPHFERYHEMSRAVMDI 103
Cdd:PRK02406 2 DCFYAAVEMRDNPELRGKPVAVGGSPGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIREI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 104 LYAESPLLEQVSIDEAFLDVTpgrftgDDP------VAIAMRIQEHV-AELGVTCSIGVASGKTVAKIASDLDKPRGLTV 176
Cdd:PRK02406 82 FRRYTDLIEPLSLDEAYLDVT------DNKlcigsaTLIAQEIRQDIfEELGLTASAGVAPNKFLAKIASDWNKPNGLFV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 177 VYPGSEATFLAPMKIRVMSGIGKQSVKRLEAVGIRTLGELATADVETLRPIFGVNAPVMRDRAAGIDERPIVTERTLKSV 256
Cdd:PRK02406 156 ITPEEVDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKFGRRLYERARGIDERPVKPDRERKSV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 257 SHERTFASDLTTRAEIEDAVDFLGSMVGRRLRRKQ--LAGHTVTLKLRYADLSIRSAQQGlganvdDEGVFIPIAKRLIG 334
Cdd:PRK02406 236 GVERTFAEDLYDLEACLAELPRLAEKLERRLERAKpdKRIKTVGVKLKFADFQQTTKEHT------ADPLDKADLIELLA 309
|
330 340 350
....*....|....*....|....*....|...
gi 1391400002 335 EIWQE---GDAVRLVGVGVSGFDTQDE-QLDLF 363
Cdd:PRK02406 310 QALLRrlgGRGVRLLGVGVTLLEPQLErQLLLD 342
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
18-388 |
2.27e-108 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 326.51 E-value: 2.27e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 18 ILLVDLDAFFASVEQLDHPEWRGKPVIVGGRADRrGVVSTCSYEARTYGVHSAMASAVAERLCP-DAIWTTPHFERYHEM 96
Cdd:PRK03348 7 VLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGR-GVVAGASYEARVFGARSAMPMHQARRLVGnGAVVLPPRFVVYRAA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 97 SRAVMDILYAESPLLEQVSIDEAFLDvtPGRFTGDDP---VAIAMRIQEHV-AELGVTCSIGVASGKTVAKIASDLDKPR 172
Cdd:PRK03348 86 SRRVFDTLRELSPVVEQLSFDEAFVE--PAELAGASAeevEAFAERLRARVrEETGLPASVGAGSGKQIAKIASGLAKPD 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 173 GLTVVYPGSEATFLAPMKIRVMSGIGKQSVKRLEAVGIRTLGELATADVETLRPIFG-VNAPVMRDRAAGIDERPIVTER 251
Cdd:PRK03348 164 GIRVVPPGEERELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAALSEAEVANLLGaTVGPALHRLARGIDDRPVAERA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 252 TLKSVSHERTFASDLTTRAEIEDAVDFLGSMVGRRLRRKQLAGHTVTLKLRYADLSIRSAQQGLGANVDDEGVFIPIAKR 331
Cdd:PRK03348 244 EAKQISAESTFAVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSDFSTLTRSATLPYATDDAAVLAATARR 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1391400002 332 LIGEIWQEGdAVRLVGVGVSGFdTQDEQLDLFANAETEQGNAEAIAAADKVRDRFGD 388
Cdd:PRK03348 324 LLLDPDEIG-PIRLVGVGFSGL-SDVRQESLFPELDLARETAPAEEVETESAAGPSD 378
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
21-398 |
1.43e-105 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 318.41 E-value: 1.43e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 21 VDLDAFFASVEQLDHPEWRGKPVIVGGraDRRGVVSTCSYEARTYGVHSAMASAVAERLCPDAIWTTPHFERYHEMSRAV 100
Cdd:PRK02794 41 IDCDAFYASVEKRDNPELRDKPVIIGG--GKRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYVRVGREV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 101 MDILYAESPLLEQVSIDEAFLDVTPG-RFTGDDPVAIAMRIQEHV-AELGVTCSIGVASGKTVAKIASDLDKPRGLTVVY 178
Cdd:PRK02794 119 RAMMQALTPLVEPLSIDEAFLDLSGTeRLHGAPPAVVLARFARRVeREIGITVSVGLSYNKFLAKIASDLDKPRGFSVIG 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 179 PGSEATFLAPMKIRVMSGIGKQSVKRLEAVGIRTLGELATADVETLRPIFGVNAPVMRDRAAGIDERPIVTERTLKSVSH 258
Cdd:PRK02794 199 RAEALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFGSMGLRLWRLARGIDDRKVSPDREAKSVSA 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 259 ERTFASDLTTRAEIEDAVDFLGSMVGRRLRRKQLAGHTVTLKLRYADLSIRSAQQGLGANVDDEGVFIPIAKRLI-GEIw 337
Cdd:PRK02794 279 ETTFETDLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRLRTRRRTLEDPTQLADRIFRTARELLeKET- 357
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1391400002 338 qEGDAVRLVGVGVSGFDTQDEQL--DLFANAETEQGNAEaiAAADKVRDRFGDGALKFGRELK 398
Cdd:PRK02794 358 -DGTAFRLIGIGVSDLSPADEADppDLLDPQATRRAAAE--RAIDALRAKFGAAAVETGRALR 417
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
15-404 |
2.25e-103 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 312.35 E-value: 2.25e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 15 GKAILLVDLDAFFASVEQLDHPEWRGKPVIVGGRA-DRRGVVSTCSYEARTYGVHSAMASAVAERLCPDAIWTTPHFERY 93
Cdd:PRK01810 4 GRVIFHVDMNSFFASVEIAYDPSLQGKPLAVAGNEkERKGIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNFDRY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 94 HEMSRAVMDILYAESPLLEQVSIDEAFLDVTPgRFTGDDPVAIAMRIQEH-VAELGVTCSIGVASGKTVAKIASDLDKPR 172
Cdd:PRK01810 84 REASRQMFQILSEFTPLVQPVSIDEGYLDITD-CYALGSPLEIAKMIQQRlLTELQLPCSIGIAPNKFLAKMASDMKKPL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 173 GLTVVYPGSEATFLAPMKIRVMSGIGKQSVKRLEAVGIRTLGELATADVETLRPIFGVNAPVMRDRAAGIDERPIVTERT 252
Cdd:PRK01810 163 GITVLRKRDVPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGIDDRPVDPEAI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 253 --LKSVSHERTFASDLTTRAEIEDAVDFLGSMVGRRLRRKQLAGHTVTLKLRYADLSIRSAQQGLGANVDDEGVFIPIAK 330
Cdd:PRK01810 243 yqFKSVGNSTTLSHDMDEEKELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRRTITRSKTLKNPIWEKRDIFQAAS 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 331 RLIGEIWqEGDAVRLvgVGVSGFDTQD-----EQLDLFANaeTEQGNAEAIAAA-DKVRDRFGDGALKFGRELKLKAKDT 404
Cdd:PRK01810 323 RLFKQHW-NGDPVRL--LGVTATDLEWkteavKQLDLFSF--EEDAKEEPLLAViDQINDKYGMPLLQRGSQLLRKQEKT 397
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
18-363 |
3.14e-96 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 292.01 E-value: 3.14e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 18 ILLVDLDAFFASVEQLDHPEWRGKPVIVGGRADRrGVVSTCSYEARTYGVHSAMASAVAERLCPDAIWTTPHFERYHEMS 97
Cdd:PRK14133 5 IIHVDMDAFFASVEQMDNPKLKGKPVIVGGISER-GVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVRHERYKEVS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 98 RAVMDILYAESPLLEQVSIDEAFLDVTPGrftGDDPVAIAMRIQEHV-AELGVTCSIGVASGKTVAKIASDLDKPRGLTV 176
Cdd:PRK14133 84 KNIFKILYEVTPIVEPVSIDEAYLDITNI---KEEPIKIAKYIKKKVkKETGLTLSVGISYNKFLAKLASDWNKPDGIKI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 177 VYPGSEATFLAPMKIRVMSGIGKQSVKRLEAVGIRTLGELATADVETLRPIFGVNAPVMRDRAAGIDERPIVTERTLKSV 256
Cdd:PRK14133 161 ITEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKLSREFLIEYFGKFGVEIYERIRGIDYREVEVSRERKSI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 257 SHERTFASDLTTRAEIEDAVDFLGSMVGRRLRRKQLAGHTVTLKLRYADLSIRSAQQGLGANVDDEGVFIPIAKRLIgEI 336
Cdd:PRK14133 241 GKETTLKKDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQTHTKSKTLNDYIRDKEEIYNVACEIL-EH 319
|
330 340
....*....|....*....|....*...
gi 1391400002 337 WQEGDAVRLVGVGVSGF-DTQDEQLDLF 363
Cdd:PRK14133 320 INIKEPIRLIGLSVSNLsENKIEQLSFL 347
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
17-394 |
1.16e-88 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 274.17 E-value: 1.16e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 17 AILLVDLDAFFASVEQLDHPEWRGKPVIVGGradrrGVVSTCSYEARTYGVHSAMASAVAERLCPDAIWTTPHFERYHEM 96
Cdd:PRK03858 5 SILHADLDSFYASVEQRDDPALRGRPVIVGG-----GVVLAASYEAKAYGVRTAMGGRQARRLCPQAVVVPPRMSAYSRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 97 SRAVMDILYAESPLLEQVSIDEAFLDVTPGRFTGDDPVAIAMRIQEHV-AELGVTCSIGVASGKTVAKIASDLDKPRGLT 175
Cdd:PRK03858 80 SKAVFEVFRDTTPLVEGLSIDEAFLDVGGLRRISGTPVQIAARLRRRVrEEVGLPITVGVARTKFLAKVASQVAKPDGLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 176 VVYPGSEATFLAPMKIRVMSGIGKQSVKRLEAVGIRTLGELATADVETLRPIFGvnapvmrdRAAG---------IDERP 246
Cdd:PRK03858 160 VVPPDRELAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAELPESALVSLLG--------PAAGrhlhalahnRDPRR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 247 IVTERTLKSVSHERTFASDLTTRAEIEDAVDFLGSMVGRRLRRKQLAGHTVTLKLRYADLSIRSAQQGLGANVDDEGVFI 326
Cdd:PRK03858 232 VETGRRRRSVGAQRALGRGPNSPAEVDAVVVALVDRVARRMRAAGRTGRTVVLRLRFDDFTRATRSHTLPRPTASTATLL 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1391400002 327 PIAKRLIGEIW--QEGDAVRLVGVGVSGFDTQDE-QLDL-FANAETeqgNAEAIAAADKVRDRFGDGALKFG 394
Cdd:PRK03858 312 AAARDLVAAAAplIAERGLTLVGFAVSNLDDDGAqQLELpFGLRRP---GSALDAALDAVRDRFGNAAVTRA 380
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
16-397 |
5.37e-85 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 264.94 E-value: 5.37e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 16 KAILLVDLDAFFASVEQLDHPEWRGKPVIVGGRADRR-GVVSTCSYEARTYGVHSAMASAVAERLCPDAIWTTPHFERYH 94
Cdd:PRK03103 3 RVILLVDMQSFYASVEKAANPELKGRPVIVSGDPERRsGVVLAACPLAKAYGVKTAERLWEAQQKCPDLVVVKPRMQRYI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 95 EMSRAVMDILYAESPLLEQVSIDEAFLDVTPGRFTGDDPVAIAMRIQEHV-AELGVTCSIGVASGKTVAKIASDL---DK 170
Cdd:PRK03103 83 DVSLQITRILEDFTDLVEPFSIDEQFLDVTGSQKLFGSPLEIAQKIQQRImRETGVYARVGIGPNKLLAKMACDNfakKN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 171 PRGLTVVYPGSEATFLAPMKIRVMSGIGKQSVKRLEAVGIRTLGELATADVETLRPIFGVNAPVMRDRAAGIDERPiVTE 250
Cdd:PRK03103 163 PDGLFTLDKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGINGEVLWRTANGIDYSP-VTP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 251 RTL---KSVSHERTFASDLTTRAEIEDAVDFLGSMVGRRLRRKQLAGHTVTLKLRYADLSIRSA---QQGLGANVDDEGV 324
Cdd:PRK03103 242 HSLdrqKAIGHQMTLPRDYRGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFDWPTGfsrQMTLPEPTNLAME 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1391400002 325 FIPIAKRLIGEIWQeGDAVRLVGVGVSGFDTQDE-QLDLFANAEteqgNAEAIAAA-DKVRDRFGDGALKFGREL 397
Cdd:PRK03103 322 VYEAACKLFHRHWD-GKPVRRVGVTLSNLVSDDVwQLSLFGDRE----RKRSLGYVmDDIKNRFGPTAILRASSL 391
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
18-348 |
4.77e-69 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 221.82 E-value: 4.77e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 18 ILLVDLDAFFASVEQLDHPEWRGKPVIVGGRAD---RRGVVSTCSYEARTYGVHSAMASAVAERLCPDAIWTTPHFERYH 94
Cdd:PRK03352 7 VLHVDLDQFIAAVELLRRPELAGLPVIVGGNGDptePRKVVTCASYEARAFGVRAGMPLRTAARRCPDAVFLPSDPAAYD 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 95 EMSRAVMDILYAESPLLEQVSIDEAFLDVTPgrftgDDPVAIAMRIQEHVAE-LGVTCSIGVASGKTVAKIASDLDKPRG 173
Cdd:PRK03352 87 AASEEVMATLRDLGVPVEVWGWDEAFLGVDT-----DDPEALAEEIRAAVLErTGLSCSVGIGDNKLRAKIATGFAKPAG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 174 ltvVYPGSEATFLAPM---KIRVMSGIGKQSVKRLEAVGIRTLGELATADVETLRPIFG-VNAPVMRDRAAGIDERPIVT 249
Cdd:PRK03352 162 ---VFRLTDANWMAVMgdrPTDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFGpTTGPWLLLLARGGGDTEVSA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 250 E-RTLKSVSHERTFASDLTTRAEIEDAVDFLGSMV-------GRRLRRkqlaghtVTLKLRYADLSIRSAQQGLGANVDD 321
Cdd:PRK03352 239 EpWVPRSRSREVTFPQDLTDRAEVESAVRELARRVldevvaeGRPVTR-------VAVKVRTATFYTRTKIRKLPEPTTD 311
|
330 340
....*....|....*....|....*..
gi 1391400002 322 EGVFIPIAKRLIGEIwQEGDAVRLVGV 348
Cdd:PRK03352 312 PDVIEAAALDVLDRF-ELDRPVRLLGV 337
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
19-309 |
9.08e-68 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 218.38 E-value: 9.08e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 19 LLVDLDAFFASVEQLDHPEWRGKPVIVGGRADRRGVVSTCSYEARTYGVHSAMASAVAERLCPDAIWTTPHFERYHEMSR 98
Cdd:cd00424 1 LHIDFDNFFASVEQLARPELKGRPVVVVPFNSDSTCVIACSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRRLSE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 99 AVMDILYAESPLLEQVSIDEAFLDVTPGRFTGDDPVAIAMRIQEHVAE--LGVTCSIGVASGKTVAKIASDLDKPRGLTV 176
Cdd:cd00424 81 RLLSELEEVAPLVEVASIDELFLDLTGSARLLGLGSEVALRIKRHIAEqlGGITASIGIASNKLLAKLAAKYAKPDGLTI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 177 VYPGSEATFLAPMKIRVMSGIGKQSVKRLEAVGIRTLGELATA-DVETLRPIFGVNAPVMRDRAAGIDERPIVTERTLKS 255
Cdd:cd00424 161 LDPEDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLAAsPDALLALWGGVSGERLWYALRGIDDEPLSPPRPRKS 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1391400002 256 VSHERTFASDLTTRAEIEDAVDFLGSMVGRRLRRKQLAGHTVTLKLRYADLSIR 309
Cdd:cd00424 241 FSHERVLPRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDGRWS 294
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
19-352 |
1.16e-63 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 207.79 E-value: 1.16e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 19 LLVDLDAFFASVEQLDHPEWRGKPVIVGGRADRRGVVStcSYEARTYGVhsAMASAV--AERLCPDA--IWTTPHFERYH 94
Cdd:cd01700 1 ALVDCNSFYASCERVFRPLLLGRPLVVLSNNDGCVIAR--SPEAKALGI--KMGSPYfkVPDLLERHgvAVFSSNYALYG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 95 EMSRAVMDILYAESPLLEQVSIDEAFLDVTpGRFTGDDPVAIAMRIQEHV-AELGVTCSIGVASGKTVAKIASDLDK--- 170
Cdd:cd01700 77 DMSRRIMSILERFSPDVEVYSIDESFLDLT-GSLRFGDLEELARKIRRRIlQETGIPVTVGIGPTKTLAKLANDLAKkkn 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 171 --PRGLTVVYPGSEATFLAPMKIRVMSGIGKQSVKRLEAVGIRTLGELATADVETLRPIFGVNAPVMRDRAAGIDERPIV 248
Cdd:cd01700 156 pyGGVVDLTDEEVRDKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCLPLE 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 249 TER-TLKSVSHERTFASDLTTRAEIEDAVDFLGSMVGRRLRRKQLAGHTVTLKLRYA----DLSIRSAQQGLGANVDDEG 323
Cdd:cd01700 236 EYPpPKKSIGSSRSFGRDVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGTSgfsrQPKYYSATNTLPYPTNDTR 315
|
330 340
....*....|....*....|....*....
gi 1391400002 324 VFIPIAKRLIGEIWQEGDAVRLVGVGVSG 352
Cdd:cd01700 316 EIVKAALRLLYAIYRPGYAYRKAGVMLSD 344
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
21-167 |
9.02e-56 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 180.85 E-value: 9.02e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 21 VDLDAFFASVEQLDHPEWRGKPVIVGGrADRRGVVSTCSYEARTYGVHSAMASAVAERLCPDAIWTTPHFERYHEMSRAV 100
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGG-GNGRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKI 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1391400002 101 MDILYA-ESPLLEQVSIDEAFLDVTPGRFTGDDPVAIAMRIQEHVA-ELGVTCSIGVASGKTVAKIASD 167
Cdd:pfam00817 80 FEILRRfSTPKVEQASIDEAFLDLTGLEKLFGAEEALAKRLRREIAeETGLTCSIGIAPNKLLAKLASD 148
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
18-351 |
3.97e-49 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 171.73 E-value: 3.97e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 18 ILLVDLDAFFASVEQLDHPEWRGKPVIV----GGRADrrgvVSTCSYEARTYGVHSAMASAVAERLCPDAIWTTPHFERY 93
Cdd:cd01701 49 IMHVDFDCFFVSVSIRNRPDLKGKPVAVchgkGPNSE----IASCNYEARSYGIKNGMWVGQAKKLCPQLVTLPYDFEAY 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 94 HEMSRAVMDILYAESPLLEQVSIDEAFLDVT-PGRFTGDDPVAIAMRIQEHVAE-LGVTCSIGVASGKTVAKIASDLDKP 171
Cdd:cd01701 125 EEVSLTFYEILASYTDNIEAVSCDEALIDITsLLEETYELPEELAEAIRNEIREtTGCSASVGIGPNILLARLATRKAKP 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 172 RGLTVVYPGSEATFLAPMKIRVMSGIGKQSVKRLEAVGIRTLG--ELATADVETLRPIFGV-NAPVMRDRAAGIDERPIV 248
Cdd:cd01701 205 DGQYHLSAEKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGglELRSKTKEKLQKVLGPkTGEKLYDYCRGIDDRPVT 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 249 TERTLKSVSHERTFASDLTTRAEIEDAVDFLGSMVGRRLRRKQLAGHTVTLKL--RYADLSIRSAQQG------------ 314
Cdd:cd01701 285 GEKERKSVSAEINYGIRFTNVDDVEQFLQRLSEELSKRLEESNVTGRQITLKLmkRAPGAPIEPPKYMghgicdsfskss 364
|
330 340 350
....*....|....*....|....*....|....*...
gi 1391400002 315 -LGANVDDEGVFIPIAKRLIGEIWQEGDAVRLVGVGVS 351
Cdd:cd01701 365 tLGVATDDSGVIGTEAKKLFRDLSIPPEELRGVGIQVT 402
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
18-229 |
5.44e-46 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 161.88 E-value: 5.44e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 18 ILLVDLDAFFASVEQLDHPEWRGKPVIV---GGRADRRGVVSTCSYEARTYGVHSAMASAVAERLCPDAIWTTPHFERYH 94
Cdd:PRK01216 3 ILFVDFDYFFAQVEEVLNPSLKGKPVVVcvySGRFEDSGAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEVYQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 95 EMSRAVMDILYAESPLLEQVSIDEAFLDVTPGRFTGDDPVAIAMRIQEHVAE-LGVTCSIGVASGKTVAKIASDLDKPRG 173
Cdd:PRK01216 83 QVSNRIMKLLREYSEKIEIASIDEAYLDISDKVKNYQDAYNLGLEIKNKILEkEKITVTVGISKNKVFAKIAADMAKPNG 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1391400002 174 LTVVYPGSEATFLAPMKIRVMSGIGKQSVKRLEAVGIRTLGELATADVETLRPIFG 229
Cdd:PRK01216 163 IKVIDDEEVKRFINELDIADIPGIGDITAEKLKKLGVNKLVDTLRIEFDELKGIIG 218
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
19-333 |
2.28e-35 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 134.13 E-value: 2.28e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 19 LLVDLDAFFASVEQLDHPEWRGKPVIVggraDRRGVVSTCSYEARTYGVHSAMASAVAERLCPDAIWT-----TPhferY 93
Cdd:cd01703 1 IHLDLDCFYAQVEEIRDPSLKSKPLGI----QQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVngedlTP----F 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 94 HEMSRAVMDILYAESP--LLEQVSIDEAFLDVTPGRFTGDDPVAIAMRiQEHVAELGVTCSIGVASGKTVAKIASDLDKP 171
Cdd:cd01703 73 RDMSKKVYRLLRSYSWndRVERLGFDENFMDVTEMRLLVASHIAYEMR-ERIENELGLTCCAGIASNKLLAKLVGSVNKP 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 172 RGLTVVYPGSEAT---FLAPMKIRVMSGIGKQSVKRLEAVGIRTLGELATADVeTLRPIFGVnAPVMRDRAAGIDERPIV 248
Cdd:cd01703 152 NQQTTLLPPSCADlmdFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQEFSN-RNRQTVGA-APSLLELLLMVKEFGEG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 249 TERTLKSVSHER-----TFASDLTTRAEIEDAVDFLGSMVGRRLRRKqlaghtvtLKLRYADLSIRSAQQGLGANVDDeg 323
Cdd:cd01703 230 IGQRIWKLLFGRdtspvKPASDFPQQISIEDSYKKCSLEEIREARNK--------IEELLASLLERMKQDLQEVKAGD-- 299
|
330
....*....|
gi 1391400002 324 VFIPIAKRLI 333
Cdd:cd01703 300 GRRPHTLRLT 309
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
20-341 |
3.41e-35 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 133.21 E-value: 3.41e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 20 LVDLDAFFASVEQLDHPEWRGKPVIVggrADRRGVVSTcSYEARTYGVHSAMASAVAERLCPDAI------------WTT 87
Cdd:cd01702 2 HIDMDAFFAQVEQVRLGLLRNDPVAV---VQWNSIIAV-SYAARAFGVTRFMTIDEAKKKCPDLIlahvatykkgedEAD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 88 PH-----------FERYHEMSRAVMDILYAESPLLEQVSIDEAFLDVTpgrftgddpVAIAMRIQEHV-AELGVTCSIGV 155
Cdd:cd01702 78 YHenpsparhkvsLDPYRRASRKILNILKRFGDVVEKASIDEAYLDLG---------SRIVEEIRQQVyDELGYTCSAGI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 156 ASGKTVAKIASDLDKPRGLTVVYPGSEATFLAPM---KIRVMSG-IGKQSVKRLEAVGIRTLGELATADVETLRPIFGVN 231
Cdd:cd01702 149 AHNKMLAKLASGMNKPNAQTILRNDAVASFLSSLpitSIRGLGGkLGEEIIDLLGLPTEGDVAGFRSSESDLQEHFGEKL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 232 APVMRDRAAGIDERPIVTERTLKSVSHERTFASDLTTraEIEDAVDFLGSMVGR---RLR----RKQLAGHTVTLKLR-Y 303
Cdd:cd01702 229 GEWLYNLLRGIDHEPVKPRPLPKSMGSSKNFPGKTAL--STEDVQHWLLVLASElnsRLEddryENNRRPKTLVLSLRqR 306
|
330 340 350
....*....|....*....|....*....|....*...
gi 1391400002 304 ADLSIRSAQQGLGANVDDEGVfiPIAKRLIGEIWQEGD 341
Cdd:cd01702 307 GDGVRRSRSCALPRYDAQKIV--KDAFKLIKAINEEGL 342
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
21-331 |
1.72e-31 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 126.29 E-value: 1.72e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 21 VDLDAFFASVEQLDHPEWRGKPVIVGGRAdrrgVVSTCSYEARTYGVHSAMASAVAERLCPDAIWTTPHFERYHEMSRAV 100
Cdd:PTZ00205 138 LDMDMFYAAVEIKKHPEYAAIPLAIGTMT----MLQTANYVARGRGIRQGMPGFLALKICPNLLILPPDFDAYNEESNTV 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 101 MDILYAESPLLEQVSIDEAFLDVTP--GRFTGD---DPVAIAMRIQEhVAELGVTCSIGVASGKTVAKIASDLDKPRG-- 173
Cdd:PTZ00205 214 RRIVAEYDPNYISFGLDELTLEVSAyiERFEGTktaEDVASELRVRV-FGETKLTASAGIGPTAALAKIASNINKPNGqh 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 174 -LTVVYPGSEATFLAPMKIRVMSGIGKQSVKRLEAVGIRTLGELATADVE--------TLRPIFGVNAPVMR----DRAA 240
Cdd:PTZ00205 293 dLNLHTRGDVMTYVRDLGLRSVPGVGKVTEALLKGLGITTLSDIYNRRVElcyilhnnLFRFLLGASIGIMQwpdaATAA 372
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 241 GIDERPIVTERTLKSVSHERTFASdLTTRAEIEDAVDFLGSMVGRRLRRKQLAGHTVTLKLRYADLSIRSAQQGLGANVD 320
Cdd:PTZ00205 373 NTENCEGATGGQRKAISSERSFTT-PRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISLTIRWASYRYQQYTKSLIQYSD 451
|
330
....*....|....*....
gi 1391400002 321 D--------EGVFIPIAKR 331
Cdd:PTZ00205 452 DsatlrravDGLLLPHAAK 470
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
254-357 |
9.97e-27 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 102.64 E-value: 9.97e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 254 KSVSHERTFASDLTTRAEIEDAVDFLGSMVGRRLRRKQLAGHTVTLKLRYADLSIRSAQQGLGANVDDEGVFIPIAKRLI 333
Cdd:pfam11799 2 KSIGAERTFGRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFRTITRSVTLPSPTDDTDEIYRAALRLL 81
|
90 100
....*....|....*....|....
gi 1391400002 334 GEIWQeGDAVRLVGVGVSGFDTQD 357
Cdd:pfam11799 82 RRLYR-GRPVRLLGVSLSNLVPEG 104
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
20-393 |
1.40e-26 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 110.24 E-value: 1.40e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 20 LVDLDAFFASVEQLDHPEWRGKPVIVGGRADrrGVVSTCSYEARTYGVhsAMAS---AVAERLCPDAIWT-TPHFERYHE 95
Cdd:PRK03609 4 LCDVNSFYASCETVFRPDLRGKPVVVLSNND--GCVIARSAEAKALGI--KMGDpwfKQKDLFRRCGVVCfSSNYELYAD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 96 MSRAVMDILYAESPLLEQVSIDEAFLDVTpGRFTGDDPVAIAMRIQEHVAE-LGVTCSIGVASGKTVAKIASDLDKP--- 171
Cdd:PRK03609 80 MSNRVMSTLEELSPRVEIYSIDEAFCDLT-GVRNCRDLTDFGREIRATVLQrTHLTVGVGIAQTKTLAKLANHAAKKwqr 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 172 --RG-LTVVYPGSEATFLAPMKIRVMSGIGKQSVKRLEAVGIRTLGELATADVETLRPIFGVnapvmrdraagiderpiV 248
Cdd:PRK03609 159 qtGGvVDLSNLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIRKHFNV-----------------V 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 249 TERTLKSVSHE------------------RTFASDLTTRAEIEDAVDFLGSMVGRRLRRKQLAGHTVTLKLRYADLSIR- 309
Cdd:PRK03609 222 LERTVRELRGEpclsleefaptkqeivcsRSFGERITDYESMRQAICSYAARAAEKLRGEHQYCRFISTFVKTSPFALNe 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 310 -----SAQQGLGANVDDEGVFIPIAKRLIGEIWQEGDAVRLVGVGVSGFDTQD-EQLDLFANAETEQGNAEAIAAADKVR 383
Cdd:PRK03609 302 pyygnSASVKLLTPTQDSRDIIAAATRALDAIWRDGHRYQKAGVMLGDFFSQGvAQLNLFDDNAPRPGSEQLMKVLDTLN 381
|
410
....*....|
gi 1391400002 384 DRFGDGALKF 393
Cdd:PRK03609 382 AKSGKGTLYF 391
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
19-346 |
2.85e-20 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 90.90 E-value: 2.85e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 19 LLVDLDAFFASVEQLDHPEWRGKPVIVGGRADRrGVVSTCSYEARTYGVHSAMASAVAERLCPDaIWTTPHFERY-HEMS 97
Cdd:cd03468 1 LALWFPRLPLDALLRNRPADDEAPLAVVERKKA-GRILACNAAARAAGVRPGMPLAEALALCPN-LQVVEYDPEAdARAL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 98 RAVMDILYAESPLLEQVSIDEAFLDVTP-GRFTGDDPvAIAMRIQEHVAELGVTCSIGVASGKTVAKIASDLDKPRGLT- 175
Cdd:cd03468 79 QELALWLLRFTPLVALDGPDGLLLDVTGcLHLFGGED-ALAASLRAALATLGLSARAGIADTPGAAWLLARAGGGRGVLr 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 176 VVYPGSEATFLAPMKIRVmSGIGKQSVKRLEAVGIRTLGELATADVETLRPIFGVNAPVMRDRAAGIDERPIVTE--RTL 253
Cdd:cd03468 158 REALAAALVLLAPLPVAA-LRLPPETVELLARLGLRTLGDLAALPRAELARRFGLALLLRLDQAYGRDPEPLLFSppPPA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391400002 254 KSVSHERTFASDLTTraEIEDAVDFLGSMVGRRLRRKQLAGHTVTLKLRYADLSIRSAQQGLGANVDDEgvfIPIAKRLI 333
Cdd:cd03468 237 FDFRLELQLEEPIAR--GLLFPLRRLLEQLCAFLALRGLGARRLSLTLFREDGRVTRVLVGLARPSRDD---LPLLRLLR 311
|
330
....*....|....*...
gi 1391400002 334 G-----EIWQEGDAVRLV 346
Cdd:cd03468 312 ErlerlALPRGIAPVRLL 329
|
|
| HHH_5 |
pfam14520 |
Helix-hairpin-helix domain; |
194-232 |
8.04e-03 |
|
Helix-hairpin-helix domain;
Pssm-ID: 434010 [Multi-domain] Cd Length: 57 Bit Score: 34.39 E-value: 8.04e-03
10 20 30
....*....|....*....|....*....|....*....
gi 1391400002 194 MSGIGKQSVKRLEAVGIRTLGELATADVETLRPIFGVNA 232
Cdd:pfam14520 7 ISGIGPKTALALLSAGIGTVEDLAEADVDELAEIPGIGE 45
|
|
| |
