MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1379752348 185 VPEISPQECRMCGACWRSCPENVIQFDD-NTLTIAAARCTGCGGCAAVCPHQAL 237
Cdd:COG1149     5 IPVIDEEKCIGCGLCVEVCPEGAIKLDDgGAPVVDPDLCTGCGACVGVCPTGAI 58

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1379752348 185 VPEISPQECRMCGACWRSCPENVIQFDD-NTLTIAAARCTGCGGCAAVCPHQAL 237
Cdd:COG1149     5 IPVIDEEKCIGCGLCVEVCPEGAIKLDDgGAPVVDPDLCTGCGACVGVCPTGAI 58

hydrogenase 4 subunit H; Validated

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379752348 186 PEISPQECRMCGACWRSCPENV------IQFDDNTLTIAAARCTGCGGCAAVCPHQALWLRFDVEPASTRHSAAYT---- 255
Cdd:PRK08222   33 PDLMPSQCIACGACTCACPANAltiqtdDQQNSRTWQLYLGRCIYCGRCEEVCPTRAIQLTNNFELTVTNKADLYTratf 112

                          90
                  ....*....|..
gi 1379752348 256 --LTCESCKRTF 265
Cdd:PRK08222  113 hlQRCSRCERPF 124

archaeoflavoprotein, MJ0208 family; This model describes one of two paralogous families of archaealflavoprotein. The other, described by TIGR02699 and typified by the partially characterized AF1518 of Archaeoglobus fulgidus, is a homodimeric FMN-containing flavoprotein that accepts electrons from ferredoxin and can transfer them to various oxidoreductases. The function of this protein family is unknown. [Unknown function, General]

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1379752348  29 CADVCPAQAFSLAQGQVSIDTTRCIACGDCLFVCPVDAITGIKPVKRFVQ 78
Cdd:TIGR02700 156 CVDACPRSAIDMVDGKAFIRLLKCVGCGKCKEACPYNAIHGGLEYEMRVR 205

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1379752348 191 QECRMCGACWRSCPENVIQFDDN---TLTIAAARCTGCGGCAAVCPHQAL 237
Cdd:cd10564    13 DLCTRCGDCVEACPEGIIVRGDGgfpELDFSRGECTFCGACAEACPEGAL 62

NADH-quinone oxidoreductase subunit NuoI;

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1379752348  29 CADVCPAQAFSLAQGQV----------SIDTTRCIACGDCLFVCPVDAIT 68
Cdd:PRK05888   66 CAAICPADAITIEAAERedgrrrttryDINFGRCIFCGFCEEACPTDAIV 115

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1379752348 185 VPEISPQECRMCGACWRSCPENVIQFDD-NTLTIAAARCTGCGGCAAVCPHQAL 237
Cdd:COG1149     5 IPVIDEEKCIGCGLCVEVCPEGAIKLDDgGAPVVDPDLCTGCGACVGVCPTGAI 58

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379752348 141 HVVGAEINASRRTLFHVPRDAITPCAVEPGKRRLRQAFSAFSECVPEISPQECRMCGACWRSCPENVIQFDDNTLTIAAA 220
Cdd:COG4624    41 HVDDDSACSCCPRCCLCCCCCCRCCVAISCIQVRGIIIIDKRGPSIIRDKEKCKNCYPCVRACPVKAIKVDDGKAEIDEE 120

                          90       100
                  ....*....|....*....|....*
gi 1379752348 221 RCTGCGGCAAVCPHQALWLRFDVEP 245
Cdd:COG4624   121 KCISCGQCVAVCPFGAITEKSDIEK 145

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1379752348 174 LRQAFSAFSECVPEISPQECRMCGACWRSCPENVIQFD-DNTLTIAAARCTGCGGCAAVCPHQALWLR 240
Cdd:COG1148   479 LSKGELGVEPSVAEVDPEKCTGCGRCVEVCPYGAISIDeKGVAEVNPALCKGCGTCAAACPSGAISLK 546

Ferredoxin [Energy production and conversion];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379752348 143 VGAEINASRRTLFHVPRDAITPCAVEPGKRRLRQAFSAFSECVPEISPQECRMCGACWRSCPENVIQFDDNT--LTIAAA 220
Cdd:COG1145   134 VIAAALAEAGLAILGAAAPVDALAISGGKKIEEELKIAIKKAKAVIDAEKCIGCGLCVKVCPTGAIRLKDGKpqIVVDPD 213

                          90
                  ....*....|....*....
gi 1379752348 221 RCTGCGGCAAVCPHQALWL 239
Cdd:COG1145   214 KCIGCGACVKVCPVGAISL 232

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1379752348  28 ACADVCPAQAFSLAQGQVSIDTTRCIACGDCLFVCPVDAITGIKPVKR 75
Cdd:COG4231    29 ACVKVCPADAIEEGDGKAVIDPDLCIGCGSCVQVCPVDAIKLEKRVPE 76

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1379752348   1 MVNLTIDPVVDVTQACVRRRFRFSSCRACADVCPAQAFSLAQGQVSIDTTRCIACGDCLFVCPVDAIT---GIKPVKRF 76
Cdd:COG4624    71 IQVRGIIIIDKRGPSIIRDKEKCKNCYPCVRACPVKAIKVDDGKAEIDEEKCISCGQCVAVCPFGAITeksDIEKVKKA 149

Uncharacterized Fe-S cluster protein [Function unknown];

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1379752348  28 ACADVCPAQAFSLAQGQVSIDTTRCIACGDCLFVCPVDAIT 68
Cdd:COG2768    18 ACVKVCPVGAISIEDGKAVIDPEKCIGCGACIEVCPVGAIK 58

archaeoflavoprotein, MJ0208 family; This model describes one of two paralogous families of archaealflavoprotein. The other, described by TIGR02699 and typified by the partially characterized AF1518 of Archaeoglobus fulgidus, is a homodimeric FMN-containing flavoprotein that accepts electrons from ferredoxin and can transfer them to various oxidoreductases. The function of this protein family is unknown. [Unknown function, General]

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1379752348 162 ITPCAVEPGKRRLRQAFSafsecvpeISPQECRMCGACWRSCPENVIQFDDNTLTIAAARCTGCGGCAAVCPHQAL 237
Cdd:TIGR02700 127 VVPVDYEEGIIRTITPYM--------IDRKRCKGCGICVDACPRSAIDMVDGKAFIRLLKCVGCGKCKEACPYNAI 194

2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; A number of anaerobic and microaerophilic species lack pyruvate dehydrogenase and have instead a four subunit, oxygen-sensitive pyruvate oxidoreductase, with either ferredoxins or flavodoxins used as the acceptor. Several related four-subunit enzymes may exist in the same species. This model describes a subfamily of delta subunits, representing mostly pyruvate, 2-ketoisovalerate, and 2-oxoglutarate specific enzymes. The delta subunit is the smallest and resembles ferredoxins.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1379752348 186 PEISPQECRMCGACWRSCPENVIQFDDNTLT-IAAARCTGCGGCAAVCPHQALWLR 240
Cdd:TIGR02179  20 PVVDKEKCIKCKNCWLYCPEGAIQEDEGGFVgIDYDYCKGCGICANVCPVKAIEMV 75

formate hydrogenlyase complex iron-sulfur subunit; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379752348 186 PEISPQECRMCGACWRSCPENVI--QFDDNTLTIA----AARCTGCGGCAAVCPHQALWLRFDVEPASTRHSAAY----- 254
Cdd:PRK12387   33 PEYNPQQCIGCAACVNACPSNALtvETDLATGELAwefnLGRCIFCGRCEEVCPTAAIKLSQEFELAVWKKEDLLqqsef 112

                          90
                  ....*....|..
gi 1379752348 255 -TLTCESCKRTF 265
Cdd:PRK12387  113 aLCNCRVCGRPF 124

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1379752348 190 PQECRMCGACWRSCPENVIQFDDN----TLTIAAARCTGCGGCAAVCPHQALWLRFDVEPASTRH 250
Cdd:COG1143     1 EDKCIGCGLCVRVCPVDAITIEDGepgkVYVIDPDKCIGCGLCVEVCPTGAISMTPFELAVEDRE 65

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1379752348  29 CADVCPAQAFSLAQGQVSIDTTRCIACGDCLFVCPVDAIT 68
Cdd:cd10554    64 CANVCPVGAISQEDGVVQVDEERCIGCKLCVLACPFGAIE 103

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1379752348 191 QECRMCGACWRSCPENVIQFDDN---TLTIAAARCTGCGGCAAVCPHQAL 237
Cdd:cd10564    13 DLCTRCGDCVEACPEGIIVRGDGgfpELDFSRGECTFCGACAEACPEGAL 62

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1379752348  28 ACADVCPAQA--FSLAQGQV---SIDTTRCIACGDCLFVCPVDAIT 68
Cdd:cd10564    90 SCQDACPTQAirFRPRLGGIalpELDADACTGCGACVSVCPVGAIT 135

3-methyl-2-oxobutanoate dehydrogenase subunit delta;

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1379752348 185 VPEISPQECRMCGACWRSCPENVIQF-DDNTLTIAAARCTGCGGCAAVCPHQAL 237
Cdd:PRK09623   45 MPVVDESKCVKCYICWKFCPEPAIYIkEDGYVAIDYDYCKGCGICANECPTKAI 98

bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily of SIMIBI superfamily. Proteins in this superfamily contain an ATP-binding domain and use energy from hydrolysis of ATP to transfer electron or ion. The specific function of this family is unknown.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1379752348 184 CVPEISPQECRMCGACWRSCPENVIQFDDNTLTIAAARCTGCGGCAAVCPHQALWLR 240
Cdd:cd03110    57 KKAFIDQEKCIRCGNCERVCKFGAILEFFQKLIVDESLCEGCGACVIICPRGAIYLK 113

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1379752348  29 CADVCPAQAFSLAQG-QVSIDTTRCIACGDCLFVCPVDAIT 68
Cdd:COG1144    38 CWIVCPDGAIRVDDGkYYGIDYDYCKGCGICAEVCPVKAIE 78

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1379752348 186 PEISPQECRMCGACWRSCPENVIQFDDNTLTIAAA-----RCTGCGGCAAVCPHQAL 237
Cdd:cd10549     1 LKYDPEKCIGCGICVKACPTDAIELGPNGAIARGPeidedKCVFCGACVEVCPTGAI 57

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1379752348  29 CADVCPAQAFSL-AQGQVSIDTTRCIACGDCLFVCPVDAI 67
Cdd:cd10549    86 CVKVCPVDAITLeDELEIVIDKEKCIGCGICAEVCPVNAI 125

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379752348  28 ACADVCPAQAFSLAQG-----QVSIDTTRCIACGDCLFVCPVDAIT--------GIKPVKRFVQGDTLVG 84
Cdd:cd10549    13 ICVKACPTDAIELGPNgaiarGPEIDEDKCVFCGACVEVCPTGAIEltpegkeyVPKEKEAEIDEEKCIG 82

ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of the periplasmic nitrate reductase system, as in Escherichia coli. NapF interacts with the catalytic subunit, NapA, and may be an accessory protein for NapA maturation. [Energy metabolism, Electron transport]

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1379752348 193 CRMCGACWRSCPENVIQFDDN---TLTIAAARCTGCGGCAAVCPHQALWLRF 241
Cdd:TIGR00402  36 CTRCGECASACENNILQLGQQgqpTVEFDNAECDFCGKCAEACPTNAFHPRF 87

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1379752348 187 EISPQECRMCGACWRSCPENVIQFDDN-TLTIAAARCTGCGGCAAVCPHQAL 237
Cdd:cd10549    74 EIDEEKCIGCGLCVKVCPVDAITLEDElEIVIDKEKCIGCGICAEVCPVNAI 125

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1379752348  28 ACADVCPAQAFS-LAQGQVSIDTTRCIACGDCLFVCPVDAI 67
Cdd:COG0437    67 PCVKVCPTGATYkREDGIVLVDYDKCIGCRYCVAACPYGAP 107

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1379752348  29 CADVCPAQAFSL--AQGQV--------SIDTTRCIACGDCLFVCPVDAI 67
Cdd:TIGR01971  51 CAAVCPADAIRVvpAEGEDgkrrlkfyEINFGRCIFCGLCEEACPTDAI 99

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1379752348  28 ACADVCPAQAFSL-AQGQVSIDTTRCIACGDCLFVCPVDAI 67
Cdd:cd04410    57 PCVKACPTGAIYKdEDGIVLIDEDKCIGCGSCVEACPYGAI 97

NADH-plastoquinone oxidoreductase subunit; Provisional

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1379752348  29 CADVCPAQAFSL--AQGQVSIDTTRCIACGDCLFVCPVDAI 67
Cdd:PRK08348   50 CVTVCPAGVFVYlpEIRKVALWTGRCVFCGQCVDVCPTGAL 90

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1379752348  28 ACADVCPAQAFSL--AQGQVSIDTTRCIACGDCLFVCPVDAITGI 70
Cdd:cd10550    56 PCVEACPVGAISRdeETGAVVVDEDKCIGCGMCVEACPFGAIRVD 100

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1379752348 187 EISPQECRMCGACWRSCPENVIQFDDNTLtiAAARCTGCGG---------CAAVCPHQALWL 239
Cdd:cd04410    76 LIDEDKCIGCGSCVEACPYGAIVFDPEPG--KAVKCDLCGDrldeglepaCVKACPTGALTF 135

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1379752348 186 PEISPQECRMCGACWRSCPEN-------VIQFDDNTLTIAAARCTGCGGCAAVCP 233
Cdd:pfam13237   2 VVIDPDKCIGCGRCTAACPAGltrvgaiVERLEGEAVRIGVWKCIGCGACVEACP 56

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1379752348  28 ACADVCPAQAFS-LAQGQVSIDTTRCIACGDCLFVCPVDAI 67
Cdd:cd16371    61 ACVKVCPTGAITkREDGIVVVDQDKCIGCGYCVWACPYGAP 101

tetrathionate reductase subunit TtrB;

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1379752348  29 CADVCPAQA-FSLAQGQVSIDTTRCIACGDCLFVCPVDA 66
Cdd:PRK14993  108 CVPVCPVQAtFQREDGIVVVDNKRCVGCAYCVQACPYDA 146

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1379752348  28 ACADVCPAQA---------FSLAQGQVSIDTTRCIACGDCLFVCPVDAIT 68
Cdd:cd10549    47 ACVEVCPTGAieltpegkeYVPKEKEAEIDEEKCIGCGLCVKVCPVDAIT 96

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1379752348  28 ACADVCPAQA-FSLAQGQVSIDTTRCIACGDCLFVCPVDAI 67
Cdd:cd10562    77 ACVKVCPTGAlYKTENGAVVVDEDKCIGCGYCVAACPFDVP 117

NADH-plastoquinone oxidoreductase subunit; Provisional

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1379752348 193 CRMCGACWRSCPENVIQF--DDNTLTIAAARCTGCGGCAAVCPHQALWLRFDVEPAS 247
Cdd:PRK08348   44 CVGCRMCVTVCPAGVFVYlpEIRKVALWTGRCVFCGQCVDVCPTGALQMSDDFLLAS 100

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1379752348  28 ACADVCPAQA-FSLAQGQVSIDTTRCIACGDCLFVCPVDAIT 68
Cdd:cd10551    60 PCVKVCPTGAtYKREDGIVLVDYDKCIGCRYCMAACPYGARY 101

ferredoxin-like protein;

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1379752348  29 CADVCPAQAFSLAQ--GQVSIDTTRCIACGDCLFVCP 63
Cdd:PRK09898  131 CMNVCPIGAITWQQkeGCITVDHKRCIGCSACTTACP 167

putative oxidoreductase Fe-S binding subunit; Reviewed

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1379752348  29 CADVCPAQAFSLAQGQVSIDTTRCIACGDCLFVCPVDAI 67
Cdd:PRK12809   64 CVTACPVNALTFQSDSVQLDEQKCIGCKRCAIACPFGVV 102

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1379752348 188 ISPQECRMCGACWRSCPENVIQ---FDDNT-LTIAAARCTGCGGCAAVCP 233
Cdd:pfam14697   3 IDEDTCIGCGKCYIACPDTSHQaivGDGKRhHTVIEDECTGCNLCVSVCP 52

hypothetical protein; Provisional

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1379752348  29 CADVCPAQAFSLAQG--QVSIDTTRCIACGDCLFVCPV 64
Cdd:PRK13795  589 CVGACPTGAIRIEEGkrKISVDEEKCIHCGKCTEVCPV 626