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Conserved domains on  [gi|1356962791|gb|PRK24956|]
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UDP-N-acetylmuramoylalanine--D-glutamate ligase [Haemophilus influenzae]

Protein Classification

Mur ligase family protein( domain architecture ID 11433699)

Mur ligase family protein similar to UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase (MurD) and UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase (MurD2), which catalyze the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)

CATH:  3.40.1190.10|3.90.190.20|3.40.50.720
EC:  6.3.2.-
Gene Ontology:  GO:0008764|GO:0005524

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 4-434 0e+00

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


:

Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 568.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791   4 YQNKNITIIGLGKTGLSCVDYLLSQQANIRVIDTRKKPTGID-KLPQ-NIPLHTGSLNQEWLLESDMIVISPGLAVKTPE 81
Cdd:COG0771     2 LKGKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPAPELAAaELEApGVEVVLGEHPEELLDGADLVVKSPGIPPDHPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791  82 IQTALKAGVEVIGDIELFCRAATKPIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGIPALSLLNEDC--ELYVLEL 159
Cdd:COG0771    82 LKAARAAGIPVIGEIELAYRLSPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGNIGTPLLDLLLEPEppDVYVLEL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 160 SSFQLETTYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRIYHNAEVG---VLNNEDKLTFGEGENQARQTVSF---AE 233
Cdd:COG0771   162 SSFQLETTPSLRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPDdyaVLNADDPLTRALAEEAKARVVPFslkEP 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 234 NSADYWLktENGKQYLMVKDEVILPCEEVTLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQANGI 313
Cdd:COG0771   242 LEGGAGL--EDGKLVDRASGEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEINGV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 314 RWINDSKATNVGSTVAALAGLyiEGKLHLLLGGDGKGADFSELAELINQPHIICYCFGRDGVQLAKFSSQS----YLFET 389
Cdd:COG0771   320 RFINDSKATNPDATLAALESF--DGPVVLIAGGLDKGADFSPLAPAVAERVKAVVLIGEDAEKIAAALAGAgvpvVIVET 397

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1356962791 390 MEQAIEFLRPTLQSGDMVLLSPACASLDQFASFEKRGEEFTHLAQ 434
Cdd:COG0771   398 MEEAVAAAAELARPGDVVLLSPACASFDQFKNYEERGDVFKEAVR 442
 
Name Accession Description Interval E-value
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 4-434 0e+00

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 568.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791   4 YQNKNITIIGLGKTGLSCVDYLLSQQANIRVIDTRKKPTGID-KLPQ-NIPLHTGSLNQEWLLESDMIVISPGLAVKTPE 81
Cdd:COG0771     2 LKGKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPAPELAAaELEApGVEVVLGEHPEELLDGADLVVKSPGIPPDHPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791  82 IQTALKAGVEVIGDIELFCRAATKPIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGIPALSLLNEDC--ELYVLEL 159
Cdd:COG0771    82 LKAARAAGIPVIGEIELAYRLSPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGNIGTPLLDLLLEPEppDVYVLEL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 160 SSFQLETTYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRIYHNAEVG---VLNNEDKLTFGEGENQARQTVSF---AE 233
Cdd:COG0771   162 SSFQLETTPSLRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPDdyaVLNADDPLTRALAEEAKARVVPFslkEP 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 234 NSADYWLktENGKQYLMVKDEVILPCEEVTLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQANGI 313
Cdd:COG0771   242 LEGGAGL--EDGKLVDRASGEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEINGV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 314 RWINDSKATNVGSTVAALAGLyiEGKLHLLLGGDGKGADFSELAELINQPHIICYCFGRDGVQLAKFSSQS----YLFET 389
Cdd:COG0771   320 RFINDSKATNPDATLAALESF--DGPVVLIAGGLDKGADFSPLAPAVAERVKAVVLIGEDAEKIAAALAGAgvpvVIVET 397

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1356962791 390 MEQAIEFLRPTLQSGDMVLLSPACASLDQFASFEKRGEEFTHLAQ 434
Cdd:COG0771   398 MEEAVAAAAELARPGDVVLLSPACASFDQFKNYEERGDVFKEAVR 442
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 8-434 0e+00

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 553.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791   8 NITIIGLGKTGLSCVDYLLSQQANIRVID-----TRKKPTGIDKLPQNIPLHTGsLNQEWLLESDMIVISPGLAVKTPEI 82
Cdd:TIGR01087   1 KILILGLGKTGRAVARFLHKKGAEVTVTDlkpneELEPSMGQLRLNEGSVLHTG-LHLEDLNNADLVVKSPGIPPDHPLV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791  83 QTALKAGVEVIGDIELFCRAATKPIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGIPALSLLN-EDCELYVLELSS 161
Cdd:TIGR01087  80 QAAAKRGIPVVGDIELFLRLVPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGNIGTPALEVLDqEGAELYVLELSS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 162 FQLETTYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRIYHNA---EVGVLNNEDK-LTFGEGENQARQTVSFAENSAD 237
Cdd:TIGR01087 160 FQLETTESLRPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQtegDVAVLNADDPrFARLAQKSKAQVIWFSVEKDAE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 238 YWLKTENGKQYLMVKDevilpcEEVTLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQANGIRWIN 317
Cdd:TIGR01087 240 RGLCIRDGGLYLKPND------LEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVHFYN 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 318 DSKATNVGSTVAALAGLYIegKLHLLLGGDGKGADFSELAELINQPHIICYCFGRDGVQLAKFSSQS----YLFETMEQA 393
Cdd:TIGR01087 314 DSKATNVHATLAALSAFDN--PVILIVGGDDKGADFSPLAPAAAGKVKAVLAIGEDAAKIAPLLKEAglsvYLVESLEEA 391

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1356962791 394 IEFLRPTLQSGDMVLLSPACASLDQFASFEKRGEEFTHLAQ 434
Cdd:TIGR01087 392 VQAAREVASPGDVVLLSPACASFDQFKSYEERGEKFKELVR 432
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 1-429 3.77e-107

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 324.23  E-value: 3.77e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791   1 MNaYQNKNITIIGLGKTGLSCVDYLLSQQANIRVIDTRKK---PTGIDKLPQ-NIPLHTGSLNQEWLLESDMIVISPGLA 76
Cdd:PRK14106    1 ME-LKGKKVLVVGAGVSGLALAKFLKKLGAKVILTDEKEEdqlKEALEELGElGIELVLGEYPEEFLEGVDLVVVSPGVP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791  77 VKTPEIQTALKAGVEVIGDIELFCRAATKPIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGIP----ALSLLNEDc 152
Cdd:PRK14106   80 LDSPPVVQAHKKGIEVIGEVELAYRFSKAPIVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGNIGYPlidaVEEYGEDD- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 153 eLYVLELSSFQLETTYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRIYHN---AEVGVLNNEDKLTFGEGENQARQTV 229
Cdd:PRK14106  159 -IIVAEVSSFQLETIKEFKPKVGCILNITPDHLDRHKTMENYIKAKARIFENqrpSDYTVLNYDDPRTRSLAKKAKARVI 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 230 SFA-----ENSadYWLktENGKQYLMV--KDEVILPCEEVTLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDH 302
Cdd:PRK14106  238 FFSrksllEEG--VFV--KNGKIVISLggKEEEVIDIDEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEH 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 303 RFQLVHQANGIRWINDSKATNVGSTVAALAGLyiEGKLHLLLGGDGKGADFSELAELINQP--HIICYCFGRDGV--QLA 378
Cdd:PRK14106  314 RIEFVAEINGVKFINDSKGTNPDAAIKALEAY--ETPIVLIAGGYDKGSDFDEFAKAFKEKvkKLILLGETAQEIaeAAR 391

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1356962791 379 KFSSQSYLF-ETMEQAIEFLRPTLQSGDMVLLSPACASLDQFASFEKRGEEF 429
Cdd:PRK14106  392 KYGFDNILFaETLEEAVKKAYEIAKPGDVVLLSPACASWDMFKNFEERGRLF 443
Mur_ligase_M pfam08245
Mur ligase middle domain;
110-280 1.97e-29

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 113.55  E-value: 1.97e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 110 ITGSNGKSTVTTLVYEMAKAAGVKVGMGGN------------IGIPAL--SLLNEDCELYVLELSSFQLE---TTYSLKA 172
Cdd:pfam08245   1 VTGTNGKTTTTELIAAILSLAGGVIGTIGTyigksgnttnnaIGLPLTlaEMVEAGAEYAVLEVSSHGLGegrLSGLLKP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 173 AAATVLNVTEDHMDRYMDLEDYRQAKLRIY---HNAEVGVLNNEDKLT---FGEGENQARQTVSFAENS-ADYWLK---- 241
Cdd:pfam08245  81 DIAVFTNISPDHLDFHGTMENYAKAKAELFeglPEDGIAVINADDPYGaflIAKLKKAGVRVITYGIEGeADLRAAniel 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1356962791 242 TENGKQY-LMVKDEVILPCeEVTLVGRHNYMNILAATALA 280
Cdd:pfam08245 161 SSDGTSFdLFTVPGGELEI-EIPLLGRHNVYNALAAIAAA 199
 
Name Accession Description Interval E-value
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 4-434 0e+00

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 568.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791   4 YQNKNITIIGLGKTGLSCVDYLLSQQANIRVIDTRKKPTGID-KLPQ-NIPLHTGSLNQEWLLESDMIVISPGLAVKTPE 81
Cdd:COG0771     2 LKGKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPAPELAAaELEApGVEVVLGEHPEELLDGADLVVKSPGIPPDHPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791  82 IQTALKAGVEVIGDIELFCRAATKPIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGIPALSLLNEDC--ELYVLEL 159
Cdd:COG0771    82 LKAARAAGIPVIGEIELAYRLSPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGNIGTPLLDLLLEPEppDVYVLEL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 160 SSFQLETTYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRIYHNAEVG---VLNNEDKLTFGEGENQARQTVSF---AE 233
Cdd:COG0771   162 SSFQLETTPSLRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPDdyaVLNADDPLTRALAEEAKARVVPFslkEP 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 234 NSADYWLktENGKQYLMVKDEVILPCEEVTLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQANGI 313
Cdd:COG0771   242 LEGGAGL--EDGKLVDRASGEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEINGV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 314 RWINDSKATNVGSTVAALAGLyiEGKLHLLLGGDGKGADFSELAELINQPHIICYCFGRDGVQLAKFSSQS----YLFET 389
Cdd:COG0771   320 RFINDSKATNPDATLAALESF--DGPVVLIAGGLDKGADFSPLAPAVAERVKAVVLIGEDAEKIAAALAGAgvpvVIVET 397

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1356962791 390 MEQAIEFLRPTLQSGDMVLLSPACASLDQFASFEKRGEEFTHLAQ 434
Cdd:COG0771   398 MEEAVAAAAELARPGDVVLLSPACASFDQFKNYEERGDVFKEAVR 442
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 8-434 0e+00

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 553.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791   8 NITIIGLGKTGLSCVDYLLSQQANIRVID-----TRKKPTGIDKLPQNIPLHTGsLNQEWLLESDMIVISPGLAVKTPEI 82
Cdd:TIGR01087   1 KILILGLGKTGRAVARFLHKKGAEVTVTDlkpneELEPSMGQLRLNEGSVLHTG-LHLEDLNNADLVVKSPGIPPDHPLV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791  83 QTALKAGVEVIGDIELFCRAATKPIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGIPALSLLN-EDCELYVLELSS 161
Cdd:TIGR01087  80 QAAAKRGIPVVGDIELFLRLVPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGNIGTPALEVLDqEGAELYVLELSS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 162 FQLETTYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRIYHNA---EVGVLNNEDK-LTFGEGENQARQTVSFAENSAD 237
Cdd:TIGR01087 160 FQLETTESLRPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQtegDVAVLNADDPrFARLAQKSKAQVIWFSVEKDAE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 238 YWLKTENGKQYLMVKDevilpcEEVTLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQANGIRWIN 317
Cdd:TIGR01087 240 RGLCIRDGGLYLKPND------LEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVHFYN 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 318 DSKATNVGSTVAALAGLYIegKLHLLLGGDGKGADFSELAELINQPHIICYCFGRDGVQLAKFSSQS----YLFETMEQA 393
Cdd:TIGR01087 314 DSKATNVHATLAALSAFDN--PVILIVGGDDKGADFSPLAPAAAGKVKAVLAIGEDAAKIAPLLKEAglsvYLVESLEEA 391

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1356962791 394 IEFLRPTLQSGDMVLLSPACASLDQFASFEKRGEEFTHLAQ 434
Cdd:TIGR01087 392 VQAAREVASPGDVVLLSPACASFDQFKSYEERGEKFKELVR 432
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 1-429 3.77e-107

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 324.23  E-value: 3.77e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791   1 MNaYQNKNITIIGLGKTGLSCVDYLLSQQANIRVIDTRKK---PTGIDKLPQ-NIPLHTGSLNQEWLLESDMIVISPGLA 76
Cdd:PRK14106    1 ME-LKGKKVLVVGAGVSGLALAKFLKKLGAKVILTDEKEEdqlKEALEELGElGIELVLGEYPEEFLEGVDLVVVSPGVP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791  77 VKTPEIQTALKAGVEVIGDIELFCRAATKPIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGIP----ALSLLNEDc 152
Cdd:PRK14106   80 LDSPPVVQAHKKGIEVIGEVELAYRFSKAPIVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGNIGYPlidaVEEYGEDD- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 153 eLYVLELSSFQLETTYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRIYHN---AEVGVLNNEDKLTFGEGENQARQTV 229
Cdd:PRK14106  159 -IIVAEVSSFQLETIKEFKPKVGCILNITPDHLDRHKTMENYIKAKARIFENqrpSDYTVLNYDDPRTRSLAKKAKARVI 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 230 SFA-----ENSadYWLktENGKQYLMV--KDEVILPCEEVTLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDH 302
Cdd:PRK14106  238 FFSrksllEEG--VFV--KNGKIVISLggKEEEVIDIDEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEH 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 303 RFQLVHQANGIRWINDSKATNVGSTVAALAGLyiEGKLHLLLGGDGKGADFSELAELINQP--HIICYCFGRDGV--QLA 378
Cdd:PRK14106  314 RIEFVAEINGVKFINDSKGTNPDAAIKALEAY--ETPIVLIAGGYDKGSDFDEFAKAFKEKvkKLILLGETAQEIaeAAR 391

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1356962791 379 KFSSQSYLF-ETMEQAIEFLRPTLQSGDMVLLSPACASLDQFASFEKRGEEF 429
Cdd:PRK14106  392 KYGFDNILFaETLEEAVKKAYEIAKPGDVVLLSPACASWDMFKNFEERGRLF 443
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 106-409 9.40e-36

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 137.16  E-value: 9.40e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 106 PIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGN----IGIPaLSLL--NEDCELYVLELS-SFQLETTYSLKAA---AA 175
Cdd:COG0770   101 PVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNfnneIGVP-LTLLrlPEDHEFAVLEMGmNHPGEIAYLARIArpdIA 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 176 TVLNVTEDHMDRYMDLEDYRQAKLRIYHNAE---VGVLNNEDKLTFGEGENQARQTVSFAEN-SADYWLK----TENGKQ 247
Cdd:COG0770   180 VITNIGPAHLEGFGSLEGIARAKGEIFEGLPpggVAVLNADDPLLAALAERAKARVLTFGLSeDADVRAEdielDEDGTR 259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 248 YlmvkdEVILPCEEVT----LVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQANGIRWINDS-KAt 322
Cdd:COG0770   260 F-----TLHTPGGELEvtlpLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVIEGAGGVTLIDDSyNA- 333

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 323 NVGSTVAA---LAGLYIEGKLHLLLG-----GDGKGADFSELAELINQPHI-ICYCFGRDGVQLAK--FSSQSYLFETME 391
Cdd:COG0770   334 NPDSMKAAldvLAQLPGGGRRIAVLGdmlelGEESEELHREVGELAAELGIdRLFTVGELARAIAEaaGGERAEHFEDKE 413

                         330
                  ....*....|....*...
gi 1356962791 392 QAIEFLRPTLQSGDMVLL 409
Cdd:COG0770   414 ELLAALKALLRPGDVVLV 431
Mur_ligase_M pfam08245
Mur ligase middle domain;
110-280 1.97e-29

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 113.55  E-value: 1.97e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 110 ITGSNGKSTVTTLVYEMAKAAGVKVGMGGN------------IGIPAL--SLLNEDCELYVLELSSFQLE---TTYSLKA 172
Cdd:pfam08245   1 VTGTNGKTTTTELIAAILSLAGGVIGTIGTyigksgnttnnaIGLPLTlaEMVEAGAEYAVLEVSSHGLGegrLSGLLKP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 173 AAATVLNVTEDHMDRYMDLEDYRQAKLRIY---HNAEVGVLNNEDKLT---FGEGENQARQTVSFAENS-ADYWLK---- 241
Cdd:pfam08245  81 DIAVFTNISPDHLDFHGTMENYAKAKAELFeglPEDGIAVINADDPYGaflIAKLKKAGVRVITYGIEGeADLRAAniel 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1356962791 242 TENGKQY-LMVKDEVILPCeEVTLVGRHNYMNILAATALA 280
Cdd:pfam08245 161 SSDGTSFdLFTVPGGELEI-EIPLLGRHNVYNALAAIAAA 199
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 107-348 8.28e-29

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 117.49  E-value: 8.28e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 107 IVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGI-------------P-ALSL-------LNEDCELYVLELSSFQLE 165
Cdd:COG0769    82 LIGVTGTNGKTTTTYLLAQILRALGKKTGLIGTVGNgiggelipsslttPeALDLqrllaemVDAGVTHVVMEVSSHALD 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 166 T--TYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRI---YHNAEVGVLNNEDKltFGE--GENQARQTVSFA-ENSAD 237
Cdd:COG0769   162 QgrVDGVRFDVAVFTNLTRDHLDYHGTMEAYFAAKARLfdqLGPGGAAVINADDP--YGRrlAAAAPARVITYGlKADAD 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 238 YWLK----TENGKQYlmvkdEVILPCEEVT----LVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQ 309
Cdd:COG0769   240 LRATdielSADGTRF-----TLVTPGGEVEvrlpLIGRFNVYNALAAIAAALALGIDLEEILAALEKLKGVPGRMERVDG 314

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1356962791 310 ANGIRWINDSKAT-----NVGSTVAALAGlyieGKLHLLLGGDG 348
Cdd:COG0769   315 GQGPTVIVDYAHTpdaleNVLEALRPHTK----GRLIVVFGCGG 354
murE PRK00139
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
 107-313 8.55e-29

UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional


Pssm-ID: 234660 [Multi-domain]  Cd Length: 460  Bit Score: 117.54  E-value: 8.55e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 107 IVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGI--------------PALSL-------LNEDCELYVLELSSFQLE 165
Cdd:PRK00139   97 LIGVTGTNGKTTTAYLLAQILRLLGEKTALIGTLGNgiggelipsglttpDALDLqrllaelVDAGVTYAAMEVSSHALD 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 166 T--TYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRIYHNAEV-GVLNNEDKltFGEGENQARQTVSFAENSADYWLK- 241
Cdd:PRK00139  177 QgrVDGLKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLFSELGLaAVINADDE--VGRRLLALPDAYAVSMAGADLRATd 254

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1356962791 242 ---TENGkQYLMVKDEVILPceevtLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQANGI 313
Cdd:PRK00139  255 veyTDSG-QTFTLVTEVESP-----LIGRFNVSNLLAALAALLALGVPLEDALAALAKLQGVPGRMERVDAGQGP 323
murF TIGR01143
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ...
 106-409 3.93e-28

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273468 [Multi-domain]  Cd Length: 417  Bit Score: 115.06  E-value: 3.93e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 106 PIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGN----IGIPaLSLLN--EDCELYVLELS-SFQLETTYSLKAA---AA 175
Cdd:TIGR01143  75 KVIGITGSSGKTTTKEMLAAILSHKYKVFATPGNfnneIGLP-LTLLRapGDHDYAVLEMGaSHPGEIAYLAEIAkpdIA 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 176 TVLNVTEDHMDRYMDLEDYRQAKLRIY----HNAeVGVLNNEDK-LTFGEGENQARQTVSFAENSADYWLKTENGKQYLM 250
Cdd:TIGR01143 154 VITNIGPAHLEGFGSLEGIAEAKGEILqglkENG-IAVINADDPaFADLAKRLPNRNILSFGFEGGDFVAKDISYSALGS 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 251 VKDEVILPCEEVT----LVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHqANGIRWINDSKATNVGS 326
Cdd:TIGR01143 233 TSFTLVAPGGEFEvslpLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFEVQT-KNGLTLIDDTYNANPDS 311

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 327 TVAAL-AGLYIEGKLHLLLGgdgkgaDFSELAELINQPHIIC------------YCFGRDGVQLAK-FSSQSYLFETMEQ 392
Cdd:TIGR01143 312 MRAALdALARFPGKKILVLG------DMAELGEYSEELHAEVgryanslgidlvFLVGEEAAVIYDsFGKQGKHFADKDE 385

                         330
                  ....*....|....*..
gi 1356962791 393 AIEFLRPTLQSGDMVLL 409
Cdd:TIGR01143 386 LLAFLKTLVRKGDVVLV 402
MurC COG0773
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ...
 49-408 1.45e-26

UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440536 [Multi-domain]  Cd Length: 451  Bit Score: 110.93  E-value: 1.45e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791  49 QNIPLHTGSlNQEWLLESDMIVISPglAVKT--PEIQTALKAGVEVI------GDIelfcrAATKPIVGITGSNGKSTVT 120
Cdd:COG0773    48 LGIPVFIGH-DAENIDDADLVVVSS--AIPRdnPELVAARERGIPVLsraemlAEL-----MRGKRSIAVAGTHGKTTTT 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 121 TLVYEMAKAAGVKVG--MGG---NIGIPALslLNEDcELYVLE----LSSFQLettysLKAAAATVLNVTEDHMDRYMDL 191
Cdd:COG0773   120 SMLAHILEEAGLDPTflIGGilnNFGTNAR--LGDG-DYFVAEadesDGSFLH-----YSPDIAVVTNIEADHLDIYGDL 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 192 EDYRQAKLRIYHNAEVG---VLNNEDKLTFGEGENQARQTVSFAEN-SADYWLK----TENGKQY-LMVKDEVILPCEeV 262
Cdd:COG0773   192 EAIKEAFHEFARNVPFYgllVLCADDPGLRELLPRCGRPVITYGFSeDADYRAEniriDGGGSTFdVLRRGEELGEVE-L 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 263 TLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQANGIRWIND-----SKatnVGSTVAALAGLYIE 337
Cdd:COG0773   271 NLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRFELKGEVGGVTVIDDyahhpTE---IAATLAAAREKYPD 347

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 338 GKLHLLLggdgkgadfselaelinQPH----------------------IICYCFG-----RDGV-------QLAKFSSQ 383
Cdd:COG0773   348 RRLVAVF-----------------QPHrysrtrdfldefaealsladevILLDIYAarekpIPGVssedlaeAIRKRGKD 410

                         410       420
                  ....*....|....*....|....*
gi 1356962791 384 SYLFETMEQAIEFLRPTLQSGDMVL 408
Cdd:COG0773   411 VVYVPDLDELVEALAEIARPGDVVL 435
murC TIGR01082
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ...
 8-408 7.68e-25

UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273433 [Multi-domain]  Cd Length: 448  Bit Score: 106.24  E-value: 7.68e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791   8 NITIIGLGKTGLSCV-DYLLSQQANIRVIDTRKKPTgIDKLPQ-NIPLHTGSLNQEWLlESDMIVISPglAVK--TPEIQ 83
Cdd:TIGR01082   1 KIHFVGIGGIGMSGIaEILLNRGYQVSGSDIAENAT-TKRLEAlGIPIYIGHSAENLD-DADVVVVSA--AIKddNPEIV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791  84 TALKAGVEVI--GDI--ELFCRaatKPIVGITGSNGKSTVTTLVYEMAKAAGVK--VGMGGNIGipalsLLNEDC----- 152
Cdd:TIGR01082  77 EAKERGIPVIrrAEMlaELMRF---RHSIAVAGTHGKTTTTAMIAVILKEAGLDptVVVGGLVK-----EAGTNArlgsg 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 153 ELYVLEL----SSFqlettYSLKAAAATVLNVTEDHMDRYM-DLEDYRQAKLRIYHNAEVG---VLNNEDKLTFGEGENQ 224
Cdd:TIGR01082 149 EYLVAEAdesdASF-----LHLQPNVAIVTNIEPDHLDTYGsSFERLKAAFEKFIHNLPFYglaVICADDPVLRELVPKA 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 225 ARQTVSFAENSADYWLKTEN-----GKQYLMVKDEVILPCEE-VTLVGRHNYMNILAATALAQAVGINLDSIRTALRHFK 298
Cdd:TIGR01082 224 TEQVITYGGSGEDADYRAENiqqsgAEGKFSVRGKGKLYLEFtLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQ 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 299 GLDHRFQLVHQANGIRWIND--SKATNVGSTVAALAGLYIEGKL------------HLLLGGDGK--------------- 349
Cdd:TIGR01082 304 GVKRRFEILGEFGGVLLIDDyaHHPTEIKATLKAARQGYPDKRIvvvfqphrysrtRDLFDDFAKvlsdadelilldiya 383

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1356962791 350 -------GADFSELAELINQPHIIcycfgrdgvqlakfssQSYLFETMEQAIEFLRPTLQSGDMVL 408
Cdd:TIGR01082 384 ageepinGIDGKSLARKITQLGKI----------------EPYFVPDLAELVEFLAAVLQSGDLIL 433
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
 107-318 1.65e-22

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 99.31  E-value: 1.65e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 107 IVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIG--IPALSLLNED----------------------CELYVLELSSF 162
Cdd:TIGR01085  87 VIGVTGTNGKTTTTSLIAQLLRLLGKKTGLIGTIGyrLGGNDLIKNPaalttpealtlqstlaemveagAQYAVMEVSSH 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 163 QLET--TYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRIY--HNAEV-GVLNNEDKLT--FgEGENQARQTVSFAENS 235
Cdd:TIGR01085 167 ALAQgrVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFteLGLKRfAVINLDDEYGaqF-VKRLPKDITVSAITQP 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 236 ADYWLKT---------ENGKQYLMVKDEVILPCeEVTLVGRHNYMNILAATALA-QAVGINLDSIRTALRHFKGLDHRFQ 305
Cdd:TIGR01085 246 ADGRAQDikitdsgysFEGQQFTFETPAGEGHL-HTPLIGRFNVYNLLAALATLlHLGGIDLEDIVAALEKFRGVPGRME 324

                         250
                  ....*....|...
gi 1356962791 306 LVHQANGIRWIND 318
Cdd:TIGR01085 325 LVDGGQKFLVIVD 337
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 104-408 9.55e-21

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 95.16  E-value: 9.55e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 104 TKPIVGITGSNGKSTVTTLVyemAKAAGVKVGMG------GN----IGIPaLSLLN--EDCELYVLELSSFQL-ETTYSL 170
Cdd:PRK11929  602 SLPVVAITGSNGKTTTKEMI---AAILAAWQGEDrvlateGNfnneIGVP-LTLLRlrAQHRAAVFELGMNHPgEIAYLA 677

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 171 KAAAATV---LNVTEDHMDRYMDLEDYRQAKLRIYHNAE---VGVLNNEDK-----LTFGEGENQARQTVSFAENS-ADY 238
Cdd:PRK11929  678 AIAAPTValvTNAQREHQEFMHSVEAVARAKGEIIAALPedgVAVVNGDDPytaiwAKLAGARRVLRFGLQPGADVyAEK 757

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 239 WLKTENGKQYLMVKDEVILPCE--EVTL--VGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQANGIR 314
Cdd:PRK11929  758 IAKDISVGEAGGTRCQVVTPAGsaEVYLplIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCGTR 837

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 315 WINDSKATN---VGSTVAALAGLYIEGKLhLLLGGDGKGADFS-----ELAELINQPHI-ICYCFGRDGVQLAKFSSQSY 385
Cdd:PRK11929  838 IIDDTYNANpdsMRAAIDVLAELPNGPRA-LVLGDMLELGDNGpamhrEVGKYARQLGIdALITLGEAARDAAAAFGAGA 916

                         330       340
                  ....*....|....*....|....*
gi 1356962791 386 L--FETMEQAIEFLRPTLQSGDMVL 408
Cdd:PRK11929  917 RgvCASVDEIIAALRGALPEGDSVL 941
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 66-307 4.32e-19

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 90.15  E-value: 4.32e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791  66 SDMIVISPGLAVKTPEIQTALKagvevigdiELFCRAATKP-----IVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNI 140
Cdd:PRK11929   77 EDQVAAADALVLPVADLRKALG---------ELAARWYGRPseqlsLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 141 G-------IP-------ALSL---LNE----DCELYVLELSSFQLETT--YSLKAAAATVLNVTEDHMDRYMDLEDYRQA 197
Cdd:PRK11929  148 GarldgrlIPgslttpdAIILhriLARmraaGADAVAMEASSHGLEQGrlDGLRIAVAGFTNLTRDHLDYHGTMQDYEEA 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 198 KLRIY---HNAEVGVLNNEDKltfgEGENQAR------QTVSFAENSADYW----LKTENGKQYLMVKDevilPCEEVT- 263
Cdd:PRK11929  228 KAALFsklPGLGAAVINADDP----AAARLLAalprglKVGYSPQNAGADVqardLRATAHGQVFTLAT----PDGSYQl 299

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1356962791 264 ---LVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLV 307
Cdd:PRK11929  300 vtrLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVPGRMERV 346
murF PRK10773
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
 107-330 3.48e-14

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed


Pssm-ID: 182718 [Multi-domain]  Cd Length: 453  Bit Score: 73.91  E-value: 3.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 107 IVGITGSNGKstvtTLVYEMAKA----AGVKVGMGGN----IGIPaLSL--LNEDCELYVLEL-SSFQLETTYS---LKA 172
Cdd:PRK10773  102 VVALTGSSGK----TSVKEMTAAilrqCGNTLYTAGNlnndIGVP-LTLlrLTPEHDYAVIELgANHQGEIAYTvslTRP 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 173 AAATVLNVTEDHMDRYMDLEDYRQAKLRIYHN---AEVGVLNNE------------DKLTFGEGENQARQTVSFAEN--- 234
Cdd:PRK10773  177 EAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGlpeNGIAIMNADsndwlnwqsvigSKTVWRFSPNAANSVDFTATNihv 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 235 ---SADYWLKTENGKQylmvkdEVILPceevtLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDHRFQLVHQAN 311
Cdd:PRK10773  257 tshGTEFTLHTPTGSV------DVLLP-----LPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVPGRLFPIQLAE 325

                         250
                  ....*....|....*....
gi 1356962791 312 GIRWINDSKATNVGSTVAA 330
Cdd:PRK10773  326 GQLLLDDSYNANVGSMTAA 344
PRK14573 PRK14573
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
12-305 5.86e-12

bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;


Pssm-ID: 184752 [Multi-domain]  Cd Length: 809  Bit Score: 67.92  E-value: 5.86e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791  12 IGLGKTGLSCVDY-LLSQQANIRVIDTRKKPTgIDKLPQNIPLHTGSLNQEWLLESDMIVISPGLAVKTPEIQTALKAGV 90
Cdd:PRK14573   10 IGIGGIGMSALAHiLLDRGYSVSGSDLSEGKT-VEKLKAKGARFFLGHQEEHVPEDAVVVYSSSISKDNVEYLSAKSRGN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791  91 EVIGDIELFCRAATKPI-VGITGSNGKSTVTTLVYEMAKAAGV--KVGMGGnigipalslLNEDC--------ELYVLEL 159
Cdd:PRK14573   89 RLVHRAELLAELMQEQIsILVSGSHGKTTVSSLITAIFQEAKKdpSYAIGG---------LNQEGlngysgssEYFVAEA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 160 SsfqlETTYSLK---AAAATVLNVTEDHMDRY--------MDLEDY----RQAKLrIYHNAEVGVL-NNEDKLTFGEGEN 223
Cdd:PRK14573  160 D----ESDGSLKhytPEFSVITNIDNEHLSNFegdrelllASIQDFarkvQQINK-CFYNGDCPRLkGCLQGHSYGFSSS 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 224 QARQTVSFAENS-ADYWLKTENGKQYLMVkdevilpceEVTLVGRHNYMNILAATALAQAVGINLDSIRTALRHFKGLDH 302
Cdd:PRK14573  235 CDLHILSYYQEGwRSYFSAKFLGVVYQDI---------ELNLVGMHNVANAAAAMGIALTLGIDEGAIRNALKGFSGVQR 305


                  ...
gi 1356962791 303 RFQ 305
Cdd:PRK14573  306 RLE 308
PRK14016 PRK14016
cyanophycin synthetase; Provisional
 106-297 4.59e-11

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 64.79  E-value: 4.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 106 PIVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGI--------------PA---LSLLNEDCELYVLE------LSS- 161
Cdd:PRK14016  481 PIVAVTGTNGKTTTTRLIAHILKLSGKRVGMTTTDGVyidgrlidkgdctgPKsarRVLMNPDVEAAVLEtarggiLREg 560

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 162 --FQLettyslkAAAATVLNVTEDHM-DRYMD-LEDYRQAKLRIYHNAE---VGVLNNEDKLTFGEGENQARQTVSFAEN 234
Cdd:PRK14016  561 laYDR-------CDVGVVTNIGEDHLgLGGINtLEDLAKVKRVVVEAVKpdgYAVLNADDPMVAAMAERCKGKVIFFSMD 633

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356962791 235 SADYWLKT--ENGKQYLMVKD-----------EVILPCEEV--TLVGR--HNYMNILAATALAQAVGINLDSIRTALRHF 297
Cdd:PRK14016  634 PDNPVIAEhrAQGGRAVYVEGdyivlaeggweIRIISLADIplTLGGKagFNIENALAAIAAAWALGIDIELIRAGLRTF 713
Mur_ligase_C pfam02875
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ...
 302-370 2.58e-10

Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460731 [Multi-domain]  Cd Length: 87  Bit Score: 56.58  E-value: 2.58e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1356962791 302 HRFQLVHQANGIRWINDsKATNVGSTVAALAGL--YIEGKLHLLLGGDG-KGADFSELAELINQPHIICYCF 370
Cdd:pfam02875   3 GRLEVVGENNGVLVIDD-YAHNPDAMEAALRALrnLFPGRLILVFGGMGdRDAEFHALLGRLAAALADVVIL 73
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 88-136 2.96e-03

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 37.94  E-value: 2.96e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1356962791  88 AGVEVIGDIELfcraATKPIVgITGSNGKSTVTTLVYEmAKAAGVKVGM 136
Cdd:pfam00817   8 ASVELLRDPEL----KGKPVA-VGGGNGRGIVAAASYE-ARKYGVRSGM 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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