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Conserved domains on  [gi|1339315085|gb|POR04645|]
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hypothetical protein AU468_03055 [Alkalispirochaeta sphaeroplastigenens]

Protein Classification

Gfo/Idh/MocA family protein( domain architecture ID 11430574)

Gfo/Idh/MocA family protein belonging to the NAD(P)(+)-binding Rossmann-fold superfamily, may function as an oxidoreductase that catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
10-203 4.35e-35

Predicted dehydrogenase [General function prediction only];


:

Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 129.27  E-value: 4.35e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339315085  10 SGMIPAGVIGTGRIASlleedplrekpcTHAGALVATGRCTIVGGADHDEERRRLFSRRWGAPGFSDPLEMIRATAPKIL 89
Cdd:COG0673     1 MDKLRVGIIGAGGIGR------------AHAPALAALPGVELVAVADRDPERAEAFAEEYGVRVYTDYEELLADPDIDAV 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339315085  90 VVATHPDSHERYVAMAAREGVPvVVCEKPLAHTMASARRIARIEKKGALKILVNHERRFSRDYELVRDALRSRALGSLLG 169
Cdd:COG0673    69 VIATPNHLHAELAIAALEAGKH-VLCEKPLALTLEEARELVAAAEEAGVVLMVGFNRRFDPAVRAARELIDSGAIGEIRS 147
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1339315085 170 ITATL-----------FFGKNQPHHRVLHHDGTHLIDAIHFLTDD 203
Cdd:COG0673   148 VRARFghprpagpadwRFDPELAGGGALLDLGIHDIDLARWLLGS 192
 
Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
10-203 4.35e-35

Predicted dehydrogenase [General function prediction only];


Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 129.27  E-value: 4.35e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339315085  10 SGMIPAGVIGTGRIASlleedplrekpcTHAGALVATGRCTIVGGADHDEERRRLFSRRWGAPGFSDPLEMIRATAPKIL 89
Cdd:COG0673     1 MDKLRVGIIGAGGIGR------------AHAPALAALPGVELVAVADRDPERAEAFAEEYGVRVYTDYEELLADPDIDAV 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339315085  90 VVATHPDSHERYVAMAAREGVPvVVCEKPLAHTMASARRIARIEKKGALKILVNHERRFSRDYELVRDALRSRALGSLLG 169
Cdd:COG0673    69 VIATPNHLHAELAIAALEAGKH-VLCEKPLALTLEEARELVAAAEEAGVVLMVGFNRRFDPAVRAARELIDSGAIGEIRS 147
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1339315085 170 ITATL-----------FFGKNQPHHRVLHHDGTHLIDAIHFLTDD 203
Cdd:COG0673   148 VRARFghprpagpadwRFDPELAGGGALLDLGIHDIDLARWLLGS 192
GFO_IDH_MocA pfam01408
Oxidoreductase family, NAD-binding Rossmann fold; This family of enzymes utilize NADP or NAD. ...
16-144 6.32e-18

Oxidoreductase family, NAD-binding Rossmann fold; This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.


Pssm-ID: 426248 [Multi-domain]  Cd Length: 120  Bit Score: 78.40  E-value: 6.32e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339315085  16 GVIGTGRIASLleedplrekpctHAGALVATGRCT-IVGGADHDEERRRLFSRRWGAPGFSDPLEMIRATAPKILVVATH 94
Cdd:pfam01408   4 GIIGAGKIGSK------------HARALNASQPGAeLVAILDPNSERAEAVAESFGVEVYSDLEELLNDPEIDAVIVATP 71
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1339315085  95 PDSHERYVAMAAREGVPvVVCEKPLAHTMASARRIARIEKKGALKILVNH 144
Cdd:pfam01408  72 NGLHYDLAIAALEAGKH-VLCEKPLATTVEEAKELVELAKKKGVRVSVGF 120
myo_inos_iolG TIGR04380
inositol 2-dehydrogenase; All members of the seed alignment for this model are known or ...
12-173 1.68e-11

inositol 2-dehydrogenase; All members of the seed alignment for this model are known or predicted inositol 2-dehydrogenase sequences co-clustered with other enzymes for catabolism of myo-inositol or closely related compounds. Inositol 2-dehydrogenase catalyzes the first step in inositol catabolism. Members of this family may vary somewhat in their ranges of acceptable substrates and some may act on analogs to myo-inositol rather than myo-inositol per se. [Energy metabolism, Sugars]


Pssm-ID: 275173 [Multi-domain]  Cd Length: 330  Bit Score: 64.16  E-value: 1.68e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339315085  12 MIPAGVIGTGRIASLleedplrekpctHAGALVA-TGRCTIVGGADHDEERRRLFSRRWGA-PGFSDPLEMIRATAPKIL 89
Cdd:TIGR04380   1 KLKVGIIGAGRIGKV------------HAENLAThVPGARLKAIVDPFADAAAELAEKLGIePVTQDPEAALADPEIDAV 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339315085  90 VVATHPDSHERYVAMAAREGVPVVvCEKPLAHTMASARRIARIEKKGALKILVNHERRFSRDYELVRDALRSRALGSLLG 169
Cdd:TIGR04380  69 LIASPTDTHADLIIEAAAAGKHIF-CEKPIDLDLEEIKEALAAVEKAGVKLQIGFNRRFDPNFRRVKQLVEAGKIGKPEI 147

                  ....
gi 1339315085 170 ITAT 173
Cdd:TIGR04380 148 LRIT 151
PRK10206 PRK10206
putative oxidoreductase; Provisional
75-170 1.80e-08

putative oxidoreductase; Provisional


Pssm-ID: 182305 [Multi-domain]  Cd Length: 344  Bit Score: 55.21  E-value: 1.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339315085  75 SDPLEMIRATAPKILVVATHPDSHERYVAMAAREGVPVVVcEKPLAHTMASARRIARIEKKGALKILVNHERRFSRDYEL 154
Cdd:PRK10206   54 SDLDEVLNDPDVKLVVVCTHADSHFEYAKRALEAGKNVLV-EKPFTPTLAEAKELFALAKSKGLTVTPYQNRRFDSCFLT 132
                          90
                  ....*....|....*.
gi 1339315085 155 VRDALRSRALGSLLGI 170
Cdd:PRK10206  133 AKKAIESGKLGEIVEV 148
 
Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
10-203 4.35e-35

Predicted dehydrogenase [General function prediction only];


Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 129.27  E-value: 4.35e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339315085  10 SGMIPAGVIGTGRIASlleedplrekpcTHAGALVATGRCTIVGGADHDEERRRLFSRRWGAPGFSDPLEMIRATAPKIL 89
Cdd:COG0673     1 MDKLRVGIIGAGGIGR------------AHAPALAALPGVELVAVADRDPERAEAFAEEYGVRVYTDYEELLADPDIDAV 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339315085  90 VVATHPDSHERYVAMAAREGVPvVVCEKPLAHTMASARRIARIEKKGALKILVNHERRFSRDYELVRDALRSRALGSLLG 169
Cdd:COG0673    69 VIATPNHLHAELAIAALEAGKH-VLCEKPLALTLEEARELVAAAEEAGVVLMVGFNRRFDPAVRAARELIDSGAIGEIRS 147
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1339315085 170 ITATL-----------FFGKNQPHHRVLHHDGTHLIDAIHFLTDD 203
Cdd:COG0673   148 VRARFghprpagpadwRFDPELAGGGALLDLGIHDIDLARWLLGS 192
GFO_IDH_MocA pfam01408
Oxidoreductase family, NAD-binding Rossmann fold; This family of enzymes utilize NADP or NAD. ...
16-144 6.32e-18

Oxidoreductase family, NAD-binding Rossmann fold; This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.


Pssm-ID: 426248 [Multi-domain]  Cd Length: 120  Bit Score: 78.40  E-value: 6.32e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339315085  16 GVIGTGRIASLleedplrekpctHAGALVATGRCT-IVGGADHDEERRRLFSRRWGAPGFSDPLEMIRATAPKILVVATH 94
Cdd:pfam01408   4 GIIGAGKIGSK------------HARALNASQPGAeLVAILDPNSERAEAVAESFGVEVYSDLEELLNDPEIDAVIVATP 71
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1339315085  95 PDSHERYVAMAAREGVPvVVCEKPLAHTMASARRIARIEKKGALKILVNH 144
Cdd:pfam01408  72 NGLHYDLAIAALEAGKH-VLCEKPLATTVEEAKELVELAKKKGVRVSVGF 120
myo_inos_iolG TIGR04380
inositol 2-dehydrogenase; All members of the seed alignment for this model are known or ...
12-173 1.68e-11

inositol 2-dehydrogenase; All members of the seed alignment for this model are known or predicted inositol 2-dehydrogenase sequences co-clustered with other enzymes for catabolism of myo-inositol or closely related compounds. Inositol 2-dehydrogenase catalyzes the first step in inositol catabolism. Members of this family may vary somewhat in their ranges of acceptable substrates and some may act on analogs to myo-inositol rather than myo-inositol per se. [Energy metabolism, Sugars]


Pssm-ID: 275173 [Multi-domain]  Cd Length: 330  Bit Score: 64.16  E-value: 1.68e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339315085  12 MIPAGVIGTGRIASLleedplrekpctHAGALVA-TGRCTIVGGADHDEERRRLFSRRWGA-PGFSDPLEMIRATAPKIL 89
Cdd:TIGR04380   1 KLKVGIIGAGRIGKV------------HAENLAThVPGARLKAIVDPFADAAAELAEKLGIePVTQDPEAALADPEIDAV 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339315085  90 VVATHPDSHERYVAMAAREGVPVVvCEKPLAHTMASARRIARIEKKGALKILVNHERRFSRDYELVRDALRSRALGSLLG 169
Cdd:TIGR04380  69 LIASPTDTHADLIIEAAAAGKHIF-CEKPIDLDLEEIKEALAAVEKAGVKLQIGFNRRFDPNFRRVKQLVEAGKIGKPEI 147

                  ....
gi 1339315085 170 ITAT 173
Cdd:TIGR04380 148 LRIT 151
PRK10206 PRK10206
putative oxidoreductase; Provisional
75-170 1.80e-08

putative oxidoreductase; Provisional


Pssm-ID: 182305 [Multi-domain]  Cd Length: 344  Bit Score: 55.21  E-value: 1.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339315085  75 SDPLEMIRATAPKILVVATHPDSHERYVAMAAREGVPVVVcEKPLAHTMASARRIARIEKKGALKILVNHERRFSRDYEL 154
Cdd:PRK10206   54 SDLDEVLNDPDVKLVVVCTHADSHFEYAKRALEAGKNVLV-EKPFTPTLAEAKELFALAKSKGLTVTPYQNRRFDSCFLT 132
                          90
                  ....*....|....*.
gi 1339315085 155 VRDALRSRALGSLLGI 170
Cdd:PRK10206  133 AKKAIESGKLGEIVEV 148
NAD_binding_3 pfam03447
Homoserine dehydrogenase, NAD binding domain; This domain adopts a Rossmann NAD binding fold. ...
15-143 6.39e-03

Homoserine dehydrogenase, NAD binding domain; This domain adopts a Rossmann NAD binding fold. The C-terminal domain of homoserine dehydrogenase contributes a single helix to this structural domain, which is not included in the Pfam model.


Pssm-ID: 281446 [Multi-domain]  Cd Length: 116  Bit Score: 36.13  E-value: 6.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1339315085  15 AGVIGTGrIASLLEEDPlrekpcthagalvATGRCTIVGGADHDEERRRLFSRRWGAPGFSDPLEMIRATAPKILVVATH 94
Cdd:pfam03447   2 CGAIGSG-VLEQLLRQQ-------------SEIPLELVAVADRDLLSKDPLALLPDEPLTLDLDDLIAHPDPDVVVECAS 67
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1339315085  95 PDSHERYVAMAAREGVPVVVCEKPLAHTMASARRIARIEKKGALKILVN 143
Cdd:pfam03447  68 SEAVAELVLDALKAGKDVVTASKGALADLALYEELREAAEANGARIYVE 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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