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Conserved domains on  [gi|1334564167|gb|PNV25982|]
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hypothetical protein CW642_02090 [Salmonella enterica]

Protein Classification

Trm112 family protein( domain architecture ID 10013883)

Trm112 family protein such as Homo sapiens mitochondrial protein PreY

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11827 PRK11827
protein YcaR;
1-60 6.78e-39

protein YcaR;


:

Pssm-ID: 183328  Cd Length: 60  Bit Score: 122.02  E-value: 6.78e-39
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334564167  1 MDHRLLEIIACPVCNGKLWYNQEQQELICKLDNLAFPLRDGIPVLLENEARALTSDESKS 60
Cdd:PRK11827   1 MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLETEARVLTADESKS 60
 
Name Accession Description Interval E-value
PRK11827 PRK11827
protein YcaR;
1-60 6.78e-39

protein YcaR;


Pssm-ID: 183328  Cd Length: 60  Bit Score: 122.02  E-value: 6.78e-39
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334564167  1 MDHRLLEIIACPVCNGKLWYNQEQQELICKLDNLAFPLRDGIPVLLENEARALTSDESKS 60
Cdd:PRK11827   1 MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLETEARVLTADESKS 60
Trm112 COG2835
RNA methyltransferase activator Trm112/YbaR [Translation, ribosomal structure and biogenesis];
1-60 4.75e-28

RNA methyltransferase activator Trm112/YbaR [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442083 [Multi-domain]  Cd Length: 60  Bit Score: 94.56  E-value: 4.75e-28
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334564167  1 MDHRLLEIIACPVCNGKLWYNQEQQELICKLDNLAFPLRDGIPVLLENEARALTSDESKS 60
Cdd:COG2835    1 MDPRLLEILACPVCKGPLELDKEEGELVCTACGLAYPIRDGIPVLLPDEARPLSEDEEFS 60
Trm112p pfam03966
Trm112p-like protein; The function of this family is uncertain. The bacterial members are ...
 2-41 3.71e-11

Trm112p-like protein; The function of this family is uncertain. The bacterial members are about 60-70 amino acids in length and the eukaryotic examples are about 120 amino acids in length. The C terminus contains the strongest conservation. Trm112p is required for tRNA methylation in S. cerevisiae and is found in complexes with 2 tRNA methylases (TRM9 and TRM11) also with putative methyltransferase YDR140W. The zinc-finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast. The crystal structure of Ynr046w has been determined to 1.7 A resolution. It comprises a zinc-binding domain built from both the N- and C-terminal sequences and an inserted domain, absent from bacterial and archaeal orthologs of the protein, composed of three alpha-helices.


Pssm-ID: 397869  Cd Length: 44  Bit Score: 51.40  E-value: 3.71e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 1334564167  2 DHRLLEIIACPVCNGKLW----YNQEQQELICKLDNLAFPLRDG 41
Cdd:pfam03966  1 DLLLLEILACPLCKGPLHllleYDIEEGELVCPECGLAYPIRDG 44
 
Name Accession Description Interval E-value
PRK11827 PRK11827
protein YcaR;
1-60 6.78e-39

protein YcaR;


Pssm-ID: 183328  Cd Length: 60  Bit Score: 122.02  E-value: 6.78e-39
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334564167  1 MDHRLLEIIACPVCNGKLWYNQEQQELICKLDNLAFPLRDGIPVLLENEARALTSDESKS 60
Cdd:PRK11827   1 MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLETEARVLTADESKS 60
Trm112 COG2835
RNA methyltransferase activator Trm112/YbaR [Translation, ribosomal structure and biogenesis];
1-60 4.75e-28

RNA methyltransferase activator Trm112/YbaR [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442083 [Multi-domain]  Cd Length: 60  Bit Score: 94.56  E-value: 4.75e-28
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1334564167  1 MDHRLLEIIACPVCNGKLWYNQEQQELICKLDNLAFPLRDGIPVLLENEARALTSDESKS 60
Cdd:COG2835    1 MDPRLLEILACPVCKGPLELDKEEGELVCTACGLAYPIRDGIPVLLPDEARPLSEDEEFS 60
Trm112p pfam03966
Trm112p-like protein; The function of this family is uncertain. The bacterial members are ...
 2-41 3.71e-11

Trm112p-like protein; The function of this family is uncertain. The bacterial members are about 60-70 amino acids in length and the eukaryotic examples are about 120 amino acids in length. The C terminus contains the strongest conservation. Trm112p is required for tRNA methylation in S. cerevisiae and is found in complexes with 2 tRNA methylases (TRM9 and TRM11) also with putative methyltransferase YDR140W. The zinc-finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast. The crystal structure of Ynr046w has been determined to 1.7 A resolution. It comprises a zinc-binding domain built from both the N- and C-terminal sequences and an inserted domain, absent from bacterial and archaeal orthologs of the protein, composed of three alpha-helices.


Pssm-ID: 397869  Cd Length: 44  Bit Score: 51.40  E-value: 3.71e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 1334564167  2 DHRLLEIIACPVCNGKLW----YNQEQQELICKLDNLAFPLRDG 41
Cdd:pfam03966  1 DLLLLEILACPLCKGPLHllleYDIEEGELVCPECGLAYPIRDG 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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