F-box/kelch-repeat protein [Capsicum chinense]
Protein Classification
F-box/kelch-repeat protein( domain architecture ID 13640390)
F-box/kelch-repeat protein is a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins; similar to Arabidopsis thaliana F-box protein AFR
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| F-box | pfam00646 | F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ... |
138-176 | 7.26e-11 | |||||
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. : Pssm-ID: 425796 Cd Length: 43 Bit Score: 57.16 E-value: 7.26e-11
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| PHA03098 super family | cl33709 | kelch-like protein; Provisional |
189-439 | 3.45e-07 | |||||
kelch-like protein; Provisional The actual alignment was detected with superfamily member PHA03098: Pssm-ID: 222983 [Multi-domain] Cd Length: 534 Bit Score: 52.85 E-value: 3.45e-07
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| NanM super family | cl34543 | N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; |
374-524 | 2.95e-05 | |||||
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; The actual alignment was detected with superfamily member COG3055: Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 45.92 E-value: 2.95e-05
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| Name | Accession | Description | Interval | E-value | |||||
| F-box | pfam00646 | F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ... |
138-176 | 7.26e-11 | |||||
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 425796 Cd Length: 43 Bit Score: 57.16 E-value: 7.26e-11
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| FBOX | smart00256 | A Receptor for Ubiquitination Targets; |
138-176 | 2.00e-10 | |||||
A Receptor for Ubiquitination Targets; Pssm-ID: 197608 Cd Length: 41 Bit Score: 55.91 E-value: 2.00e-10
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| F-box_AtAFR-like | cd22152 | F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ... |
138-178 | 1.00e-09 | |||||
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438923 Cd Length: 45 Bit Score: 54.11 E-value: 1.00e-09
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| PHA03098 | PHA03098 | kelch-like protein; Provisional |
189-439 | 3.45e-07 | |||||
kelch-like protein; Provisional Pssm-ID: 222983 [Multi-domain] Cd Length: 534 Bit Score: 52.85 E-value: 3.45e-07
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| NanM | COG3055 | N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; |
188-422 | 6.13e-07 | |||||
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 51.31 E-value: 6.13e-07
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| NanM | COG3055 | N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; |
374-524 | 2.95e-05 | |||||
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 45.92 E-value: 2.95e-05
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| Kelch | smart00612 | Kelch domain; |
370-418 | 9.21e-05 | |||||
Kelch domain; Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 40.23 E-value: 9.21e-05
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| Kelch_1 | pfam01344 | Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ... |
224-279 | 5.51e-04 | |||||
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415. Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 37.98 E-value: 5.51e-04
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| Name | Accession | Description | Interval | E-value | |||||
| F-box | pfam00646 | F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ... |
138-176 | 7.26e-11 | |||||
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 425796 Cd Length: 43 Bit Score: 57.16 E-value: 7.26e-11
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| FBOX | smart00256 | A Receptor for Ubiquitination Targets; |
138-176 | 2.00e-10 | |||||
A Receptor for Ubiquitination Targets; Pssm-ID: 197608 Cd Length: 41 Bit Score: 55.91 E-value: 2.00e-10
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| F-box_AtAFR-like | cd22152 | F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ... |
138-178 | 1.00e-09 | |||||
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438923 Cd Length: 45 Bit Score: 54.11 E-value: 1.00e-09
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| F-box_AtFBW1-like | cd22157 | F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ... |
137-174 | 6.65e-09 | |||||
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438928 Cd Length: 39 Bit Score: 51.69 E-value: 6.65e-09
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| F-box-like | pfam12937 | F-box-like; This is an F-box-like family. |
138-176 | 9.25e-08 | |||||
F-box-like; This is an F-box-like family. Pssm-ID: 463757 [Multi-domain] Cd Length: 45 Bit Score: 48.63 E-value: 9.25e-08
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| PHA03098 | PHA03098 | kelch-like protein; Provisional |
189-439 | 3.45e-07 | |||||
kelch-like protein; Provisional Pssm-ID: 222983 [Multi-domain] Cd Length: 534 Bit Score: 52.85 E-value: 3.45e-07
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| NanM | COG3055 | N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; |
188-422 | 6.13e-07 | |||||
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 51.31 E-value: 6.13e-07
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| F-box_AtSKIP19-like | cd22164 | F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar ... |
138-176 | 7.07e-07 | |||||
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438935 [Multi-domain] Cd Length: 47 Bit Score: 46.05 E-value: 7.07e-07
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| F-box_SF | cd09917 | F-box domain superfamily; This short domain is commonly found at the N-terminus of various ... |
138-169 | 1.54e-06 | |||||
F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures. Pssm-ID: 438852 Cd Length: 35 Bit Score: 44.74 E-value: 1.54e-06
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| F-box_FBA | cd22083 | F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box ... |
135-169 | 1.05e-05 | |||||
F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box associated (FBA) family is composed of FBXO2, FBXO6, FBXO17, FBXO27, and FBXO44, which contain a conserved G domain that mediates substrate binding. Members of this family play diverse roles in glycoprotein quality control. They bind high mannose and sulfated glycoproteins, with one FBA protein, FBXO44, failing to bind any glycans on the tested arrays. FBA proteins are components of canonical SCF (Skp1, Cullin1, and Rbx1) complexes, yet FBXO2 bound very little Cullin1, suggesting that FBXO2 may exist primarily as a heterodimer with Skp1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438855 Cd Length: 37 Bit Score: 42.38 E-value: 1.05e-05
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| F-box_FBXO6-like | cd22168 | F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily ... |
138-187 | 1.27e-05 | |||||
F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438939 [Multi-domain] Cd Length: 82 Bit Score: 43.43 E-value: 1.27e-05
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| F-box_FBXO17-like | cd22169 | F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and ... |
138-180 | 2.49e-05 | |||||
F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and similar proteins; This subfamily includes FBXO17 and FBXO27. FBXO17 is also called FBX17, F-box only protein 26 (FBX26/FBXO26), or FBG4, while FBXO27 is also called FBX27, or F-box/G-domain protein 5. FBXO17 and FBXO27 are the substrate-recognition components of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. They can recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. FBXO17 also recognizes sulfated glycans but does not bind high-mannose glycoproteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438940 Cd Length: 48 Bit Score: 41.64 E-value: 2.49e-05
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| NanM | COG3055 | N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; |
374-524 | 2.95e-05 | |||||
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 45.92 E-value: 2.95e-05
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| Kelch | smart00612 | Kelch domain; |
370-418 | 9.21e-05 | |||||
Kelch domain; Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 40.23 E-value: 9.21e-05
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| F-box_AtGID2-like | cd22151 | F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ... |
138-176 | 1.18e-04 | |||||
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438922 Cd Length: 44 Bit Score: 39.61 E-value: 1.18e-04
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| F-box_FBXO18 | cd22095 | F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ... |
138-174 | 1.53e-04 | |||||
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438867 Cd Length: 48 Bit Score: 39.56 E-value: 1.53e-04
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| Kelch_1 | pfam01344 | Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ... |
224-279 | 5.51e-04 | |||||
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415. Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 37.98 E-value: 5.51e-04
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| Kelch_6 | pfam13964 | Kelch motif; |
224-282 | 6.52e-04 | |||||
Kelch motif; Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 37.70 E-value: 6.52e-04
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| F-box_SpPof1-like | cd22147 | F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ... |
137-178 | 1.38e-03 | |||||
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438918 Cd Length: 46 Bit Score: 36.91 E-value: 1.38e-03
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| Kelch | smart00612 | Kelch domain; |
236-283 | 1.62e-03 | |||||
Kelch domain; Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 36.77 E-value: 1.62e-03
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| F-box_FBXO42 | cd22110 | F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ... |
138-169 | 2.10e-03 | |||||
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438882 Cd Length: 38 Bit Score: 36.16 E-value: 2.10e-03
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| Kelch_1 | pfam01344 | Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ... |
370-404 | 2.28e-03 | |||||
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415. Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 36.05 E-value: 2.28e-03
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| F-box_AtSKIP5-like | cd22163 | F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar ... |
138-175 | 2.85e-03 | |||||
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar proteins; AtSKIP5, also called F-box protein SKIP5, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438934 Cd Length: 46 Bit Score: 35.78 E-value: 2.85e-03
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| F-box_FBXO2 | cd22167 | F-box domain found in F-box only protein 2 (FBXO2) and similar proteins; FBXO2, also called ... |
138-181 | 3.12e-03 | |||||
F-box domain found in F-box only protein 2 (FBXO2) and similar proteins; FBXO2, also called FBX2, is a neuron-specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It binds specifically to proteins attached with N-linked high-mannose type oligosaccharides, and subsequently contributes to ubiquitination of glycoproteins. FBXO2 regulates amyloid precursor protein (APP) levels and processing in the brain, and may play a role in modulating Alzheimer disease (AD) pathogenesis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438938 [Multi-domain] Cd Length: 72 Bit Score: 36.64 E-value: 3.12e-03
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| Kelch_6 | pfam13964 | Kelch motif; |
371-406 | 4.20e-03 | |||||
Kelch motif; Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 35.39 E-value: 4.20e-03
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| F-box_FBXO33 | cd22104 | F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called ... |
138-176 | 7.20e-03 | |||||
F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438876 Cd Length: 48 Bit Score: 34.92 E-value: 7.20e-03
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