NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1260286687|gb|PEY25274|]
View 

amino acid ABC transporter permease [Bacillus cereus]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 22-229 1.17e-87

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 258.08  E-value: 1.17e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  22 SFMPMLKEAVFTTIPLTLITFIIGIILATLTALARISGSRILQWIARIYVSIIRGTPLLVQLFIIFYGLPTLNIEVEPYT 101
Cdd:COG0765    10 DYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGIDLSPFV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687 102 AAVVGFSLNVGAYASEIIRASILSIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPPLSNTFISLVKDTSLASLILVT 181
Cdd:COG0765    90 AAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGVP 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1260286687 182 EMFRKAQEIAAMNYEFLIVYFEAGLIYWVICFLLSIVQQMLEKRSERY 229
Cdd:COG0765   170 ELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 22-229 1.17e-87

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 258.08  E-value: 1.17e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  22 SFMPMLKEAVFTTIPLTLITFIIGIILATLTALARISGSRILQWIARIYVSIIRGTPLLVQLFIIFYGLPTLNIEVEPYT 101
Cdd:COG0765    10 DYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGIDLSPFV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687 102 AAVVGFSLNVGAYASEIIRASILSIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPPLSNTFISLVKDTSLASLILVT 181
Cdd:COG0765    90 AAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGVP 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1260286687 182 EMFRKAQEIAAMNYEFLIVYFEAGLIYWVICFLLSIVQQMLEKRSERY 229
Cdd:COG0765   170 ELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
PRK15100 PRK15100
cystine ABC transporter permease;
26-228 6.43e-78

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 233.49  E-value: 6.43e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  26 MLKEAVFTTIpLTLITFIIGIILATLTALARISGSRILQWIARIYVSIIRGTPLLVQLFIIFYGLPTLNIEVEPYTAAVV 105
Cdd:PRK15100   15 LLKGAGYTLQ-LSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIELDPIPAAMI 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687 106 GFSLNVGAYASEIIRASILSIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPPLSNTFISLVKDTSLASLILVTEMFR 185
Cdd:PRK15100   94 GLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFR 173

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1260286687 186 KAQEIAAMNYEFLIVYFEAGLIYWVICFLLSIVQQMLEKRSER 228
Cdd:PRK15100  174 QAQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFENQLNR 216
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 21-228 4.13e-45

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 150.00  E-value: 4.13e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  21 TSFMPMLKEAVFTTIPLTLITFIIGIILATLTALARISGSRILQWIARIYVSIIRGTPLLVQLFIIFYGLPTLNIEVEPY 100
Cdd:TIGR03004   1 TAYLPLLLQGAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVLPLIGLSLDPV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687 101 TAAVVGFSLNVGAYASEIIRASILSIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPPLSNTFISLVKDTSLASLILV 180
Cdd:TIGR03004  81 TTGVMVLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1260286687 181 TEMFRKAQEIAAMNYEFLIVYFEAGLIYWVICFLLSIVQQMLEKRSER 228
Cdd:TIGR03004 161 ADLTFAAQSIRNLTLDTLSIFAITLLCYFVMALIIMLIMRVLERVVRR 208
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 34-217 1.26e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 77.70  E-value: 1.26e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  34 TIPLTLITFIIGIILATLTALARISGSRILQWIARIYVSIIRGTPLLVQLFIIFYGLPTLNIEVEPYT---AAVVGFSLN 110
Cdd:cd06261     4 TLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGlglPALILALLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687 111 VGAYASEIIRASILSIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPPLSNTFISLVKDTSLASLILVTEMFRKAQEI 190
Cdd:cd06261    84 IAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTGL 163

                         170       180
                  ....*....|....*....|....*..
gi 1260286687 191 AAMNYEFLIVYFEAGLIYWVICFLLSI 217
Cdd:cd06261   164 LLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 45-225 3.77e-13

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 65.40  E-value: 3.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  45 GIILATLTALARisgSRILQWIARIYVSIIRGTPLLVQLFIIFYGLPTLNIEVePYTAAVVGFSLNVGAYASEIIRASIL 124
Cdd:pfam00528   1 GIPLGIIAALRR---GRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGH-GILPAIILALLGWAGYARLIRRAALR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687 125 SIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPPLSNTFISLVKDTSLASLIL----VTEMFRKAQEIAAMNYEFLIV 200
Cdd:pfam00528  77 SLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGswpgLGLLLIEAILGYDYPEIQGPV 156

                         170       180
                  ....*....|....*....|....*
gi 1260286687 201 YFeAGLIYWVICFLLSIVQQMLEKR 225
Cdd:pfam00528 157 LA-AALILLLLNLLVDILQRLLDPR 180
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 22-229 1.17e-87

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 258.08  E-value: 1.17e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  22 SFMPMLKEAVFTTIPLTLITFIIGIILATLTALARISGSRILQWIARIYVSIIRGTPLLVQLFIIFYGLPTLNIEVEPYT 101
Cdd:COG0765    10 DYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGIDLSPFV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687 102 AAVVGFSLNVGAYASEIIRASILSIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPPLSNTFISLVKDTSLASLILVT 181
Cdd:COG0765    90 AAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGVP 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1260286687 182 EMFRKAQEIAAMNYEFLIVYFEAGLIYWVICFLLSIVQQMLEKRSERY 229
Cdd:COG0765   170 ELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
PRK15100 PRK15100
cystine ABC transporter permease;
26-228 6.43e-78

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 233.49  E-value: 6.43e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  26 MLKEAVFTTIpLTLITFIIGIILATLTALARISGSRILQWIARIYVSIIRGTPLLVQLFIIFYGLPTLNIEVEPYTAAVV 105
Cdd:PRK15100   15 LLKGAGYTLQ-LSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIELDPIPAAMI 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687 106 GFSLNVGAYASEIIRASILSIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPPLSNTFISLVKDTSLASLILVTEMFR 185
Cdd:PRK15100   94 GLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFR 173

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1260286687 186 KAQEIAAMNYEFLIVYFEAGLIYWVICFLLSIVQQMLEKRSER 228
Cdd:PRK15100  174 QAQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFENQLNR 216
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 16-229 2.14e-60

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 189.15  E-value: 2.14e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  16 IDIMQTSFMPMLkEAVFTTIPLTLITFIIGIILATLTALARISGSRILQWIARIYVSIIRGTPLLVQLFIIFYGLPTLNI 95
Cdd:COG4160     3 LDLLFEYLPLLL-SGLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYGLGQFEW 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  96 --EV-------EPYTAAVVGFSLNVGAYASEIIRASILSIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPPLSNTFI 166
Cdd:COG4160    82 vrESwlwpllrDPWFCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALPAYSNEVI 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1260286687 167 SLVKDTSLASLILVTEMFRKAQEIAAMNYEFLIVYFEAGLIYWVICFLLSIVQQMLEKRSERY 229
Cdd:COG4160   162 LMLKATALASTITVMDLTGVARRIYSRTYDPFEPFLIAALIYLVITFLLTRLFRLLERRLLRH 224
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 21-228 4.13e-45

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 150.00  E-value: 4.13e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  21 TSFMPMLKEAVFTTIPLTLITFIIGIILATLTALARISGSRILQWIARIYVSIIRGTPLLVQLFIIFYGLPTLNIEVEPY 100
Cdd:TIGR03004   1 TAYLPLLLQGAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVLPLIGLSLDPV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687 101 TAAVVGFSLNVGAYASEIIRASILSIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPPLSNTFISLVKDTSLASLILV 180
Cdd:TIGR03004  81 TTGVMVLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1260286687 181 TEMFRKAQEIAAMNYEFLIVYFEAGLIYWVICFLLSIVQQMLEKRSER 228
Cdd:TIGR03004 161 ADLTFAAQSIRNLTLDTLSIFAITLLCYFVMALIIMLIMRVLERVVRR 208
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 24-225 2.09e-43

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 145.58  E-value: 2.09e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  24 MPMLKEAVFTTIPLTLITFIIGIILATLTALARISGSRILQWIARIYVSIIRGTPLLVQLFIIFYGLPTL--NIEVEPYT 101
Cdd:PRK09494   12 IPLLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMAfnDLRIDPFT 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687 102 AAVVGFSLNVGAYASEIIRASILSIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPPLSNTFISLVKDTSLASLILVT 181
Cdd:PRK09494   92 AAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIVIGVA 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1260286687 182 EMFRKAQEIAAMNYEFLIVYFEAGLIYWVICFLLSIVQQMLEKR 225
Cdd:PRK09494  172 ELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERR 215
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 21-225 7.27e-38

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 131.13  E-value: 7.27e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  21 TSFMPMLKEAVFTTIPLTLITFIIGIILATLTALARISGSRILQWIARIYVSIIRGTPLLVQLFIIFYGLPTLNIEVEPY 100
Cdd:TIGR03003   7 RQILPTLIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIGIRLPAL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687 101 TAAVVGFSLNVGAYASEIIRASILSIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPPLSNTFISLVKDTSLASLILV 180
Cdd:TIGR03003  87 VAGVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITV 166

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1260286687 181 TEMFRKAQEIAAMNYEFLIVYFEAGLIYWVICFLLSIVQQMLEKR 225
Cdd:TIGR03003 167 LELMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEAR 211
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
27-229 2.61e-33

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 120.17  E-value: 2.61e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  27 LKEAVFTTIPLTLITFIIGIILATLTALARISGSRILQWIARIYVSIIRGTP-LLVQLFIIF------------------ 87
Cdd:PRK11123    7 LASAAGMTVGLAVCALIVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPeILVVLFIYFgssqllltlsdgftlnlg 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  88 -----YGLPTLNIEVEPYTAAVVGFSLNVGAYASEIIRASILSIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPPLS 162
Cdd:PRK11123   87 fvqipVQMDIENFEVSPFLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLG 166

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1260286687 163 NTFISLVKDTSLASLILVTEMFRKAQEIAAMNYEFLIVYFEAGLIYWVICFLLSIVQQMLEKRSERY 229
Cdd:PRK11123  167 NQWLVLLKDTALVSLISVNDLMLQTKSIATRTQEPFTWYIIAAAIYLVITLISQYILKRIELRATRF 233
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 23-121 2.02e-32

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 113.40  E-value: 2.02e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  23 FMPMLKEAVFTTIPLTLITFIIGIILATLTALARISGSRILQWIARIYVSIIRGTPLLVQLFIIFYGLPTLNIEVEPYTA 102
Cdd:TIGR01726   1 NLPFLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLIGIRLSPLTA 80

                          90
                  ....*....|....*....
gi 1260286687 103 AVVGFSLNVGAYASEIIRA 121
Cdd:TIGR01726  81 AVIALTLFYGAYLAEIFRG 99
artM PRK11122
arginine ABC transporter permease ArtM;
19-225 5.56e-31

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 113.51  E-value: 5.56e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  19 MQTSFMPMLKeAVFTTIPLTLITFIIGIILATLTALARISGSRILQWIARIYVSIIRGTPLLVQLFIIFYG--------- 89
Cdd:PRK11122    1 MLEYLPELLK-GLHTSLTLTVASLLVALVLALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGpgqfpwlqe 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  90 LPTL-NIEVEPYTAAVVGFSLNVGAYASEIIRASILSIPKGQWEAAYTIGMTYPQALkRVILPQATRVSIPPLSNTFISL 168
Cdd:PRK11122   80 YPWLwHLLSQPWLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTL-RILLPYAFKRALSSYSNEVVLV 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1260286687 169 VKDTSLASLILVTEMFRKAQEIAAMNYEFLiVYFEAGLIYWVICFLLSIVQQMLEKR 225
Cdd:PRK11122  159 FKSTSLAYTITLMDVMGYSQLLYGRTYDVM-VFGAAGIIYLVVNGLLTLLMRLIERK 214
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
24-226 3.54e-30

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 111.46  E-value: 3.54e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  24 MPMLKEAVFTTIPLTLITFIIGIILATLTALARISGSRILQWIARIYVSIIRGTPLLVQLFIIFYGLPTLNIEV---EPY 100
Cdd:PRK15107   13 LPYLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGFLQNVlglSPK 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687 101 T-----AAVVGFSLNVGAYASEIIRASILSIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPPLSNTFISLVKDTSLA 175
Cdd:PRK15107   93 TdirliSAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLV 172

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1260286687 176 SLILVTEMFRKAQEIAAMNYEFLIVYFEAGLIYWVICFLLSIVQQMLEKRS 226
Cdd:PRK15107  173 YVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKKRT 223
PRK15069 PRK15069
histidine ABC transporter permease HisM;
34-225 1.54e-26

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 102.44  E-value: 1.54e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  34 TIPLTLITFIIGIILATLTALARISGSRILQWIARIYVSIIRGTPLLVQLFIIFYGLPTLNIEVE----------PYTAA 103
Cdd:PRK15069   26 TLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFYTGMYSLEIVRGtdlldaffrsGLNCT 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687 104 VVGFSLNVGAYASEIIRASILSIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPPLSNTFISLVKDTSLASLILVTEM 183
Cdd:PRK15069  106 ILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLAFTATVPDI 185

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1260286687 184 FRKAQEIAAMNYEFLIVYFEAGLIYWVICFLLSIVQQMLEKR 225
Cdd:PRK15069  186 LKIARDINSATYQPFQAFGIAAVLYLIISFVLISLFRRAERR 227
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
19-225 9.13e-22

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 89.47  E-value: 9.13e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  19 MQTSFMPMLKEAVFTTIPLTLITFIIGIILATLTALARISGSRILQWIARIYVSIIRGTPLLVQLFIIFYGLP-TLN--- 94
Cdd:PRK15135    1 MLYGFSGVILQGALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPDLVLMLLIFYGLQiALNsvt 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  95 -------IEVEPYTAAVVGFSLNVGAYASEIIRASILSIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPPLSNTFIS 167
Cdd:PRK15135   81 ealgvgqIDIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQV 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1260286687 168 LVKDTSLASLILVTEMFRKAQEIAAMNYEFLIVYFEAGLIYWVICFLLSIVQQMLEKR 225
Cdd:PRK15135  161 ILKATALVSLLGLEDVVKATQLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLLWLERR 218
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 100-175 9.26e-22

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 92.13  E-value: 9.26e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1260286687 100 YTAAVVGFSLNVGAYASEIIRASILSIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPPLSNTFISLVKDTSLA 175
Cdd:COG4597   265 FVALLLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQYLNLTKNSSLA 340
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 34-217 1.26e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 77.70  E-value: 1.26e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  34 TIPLTLITFIIGIILATLTALARISGSRILQWIARIYVSIIRGTPLLVQLFIIFYGLPTLNIEVEPYT---AAVVGFSLN 110
Cdd:cd06261     4 TLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGlglPALILALLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687 111 VGAYASEIIRASILSIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPPLSNTFISLVKDTSLASLILVTEMFRKAQEI 190
Cdd:cd06261    84 IAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTGL 163

                         170       180
                  ....*....|....*....|....*..
gi 1260286687 191 AAMNYEFLIVYFEAGLIYWVICFLLSI 217
Cdd:cd06261   164 LLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 45-225 3.77e-13

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 65.40  E-value: 3.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  45 GIILATLTALARisgSRILQWIARIYVSIIRGTPLLVQLFIIFYGLPTLNIEVePYTAAVVGFSLNVGAYASEIIRASIL 124
Cdd:pfam00528   1 GIPLGIIAALRR---GRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGH-GILPAIILALLGWAGYARLIRRAALR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687 125 SIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPPLSNTFISLVKDTSLASLIL----VTEMFRKAQEIAAMNYEFLIV 200
Cdd:pfam00528  77 SLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGswpgLGLLLIEAILGYDYPEIQGPV 156

                         170       180
                  ....*....|....*....|....*
gi 1260286687 201 YFeAGLIYWVICFLLSIVQQMLEKR 225
Cdd:pfam00528 157 LA-AALILLLLNLLVDILQRLLDPR 180
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
8-153 3.53e-06

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 47.08  E-value: 3.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687   8 VSDRLSTWIDIMQTsfmPMLKEAVFTTIPL----TLITFIIGIILATLTALARISGSRILQWIARI------------YV 71
Cdd:COG1178    36 FTDGLANFWALLSD---PYLWRALGNTLLLallvTLLSLLLGVPLAWLLARTDFPGRRLLRWLLLLplalppyvvalaWI 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  72 SIIRGTPLLVQLFIIFYGLPTLNIEvePYTAAVVGFSLNVGAYASEIIRASILSIPKGQWEAAYTIGMTYPQALKRVILP 151
Cdd:COG1178   113 ALFGPNGLLNTLLRALFGLEPPDIY--GLGGIILVLVLFNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLP 190


                  ..
gi 1260286687 152 QA 153
Cdd:COG1178   191 LL 192
PRK10782 PRK10782
D-methionine ABC transporter permease MetI;
19-169 8.54e-05

D-methionine ABC transporter permease MetI;


Pssm-ID: 182726  Cd Length: 217  Bit Score: 42.41  E-value: 8.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  19 MQTSFMPMLKEAVFTTIPLTLIT----FIIGIILATLTALAR---ISGSRILQWIARIYVSIIRGTPllvqlFIIfyglp 91
Cdd:PRK10782    1 MSEAMMWLLVRGVWETLAMTFVSgffgFVIGLPVGVLLYVTRpgqIIANAKLYRTLSALVNIFRSIP-----FII----- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  92 tLNIEVEPYTAAVVGFS---------LNVGA--YASEIIRASILSIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPP 160
Cdd:PRK10782   71 -LLVWMIPFTRVIVGTSiglqaaivpLTVGAapFIARMVENALLEIPTGLIEASRAMGATPMQIVRKVLLPEALPGLVNA 149


                  ....*....
gi 1260286687 161 LSNTFISLV 169
Cdd:PRK10782  150 ATITLITLV 158
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
14-181 5.62e-03

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 37.45  E-value: 5.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  14 TWIDIMQTSFMPMLKEAVFTTIPLTLITFIIGIILATLTA-LARISGSRILQWIARIyVSIIRGTPLLVqL---FIIFYG 89
Cdd:COG1178   323 TLDNYRFVLLDPSLLRALLNSLLLALLAALLAVLLALLLAyLVRRRRGRLARLLDRL-AMLPYAVPGIV-LglgLLLLFN 400

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1260286687  90 LPTLNIEVEPYTAAVVGFSLNVGAYASEIIRASILSIPKGQWEAAYTIGMTYPQALKRVILPQATRVSIPPLSNTFISLV 169
Cdd:COG1178   401 RPLPLLLYGTLAILVLAYVVRFLPFALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSM 480

                         170
                  ....*....|..
gi 1260286687 170 KDTSlASLILVT 181
Cdd:COG1178   481 KELS-ATLLLRP 491
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH