NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1730111|sp|P98155|]
View 

RecName: Full=Very low-density lipoprotein receptor; Short=VLDL receptor; Short=VLDL-R; Flags: Precursor

Protein Classification

LDL receptor domain-containing protein( domain architecture ID 10819482)

Low Density Lipoprotein (LDL) receptor class A domain is a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; similar to Bos taurus CD320 antigen

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
568-608 1.69e-15

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 71.04  E-value: 1.69e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1730111    568 GFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLD 608
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
237-273 1.76e-12

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 62.27  E-value: 1.76e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1730111    237 TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 273
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
33-67 2.51e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.51e-11
                        10        20        30
                ....*....|....*....|....*....|....*
gi 1730111   33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC 67
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
154-188 2.64e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.64e-11
                        10        20        30
                ....*....|....*....|....*....|....*
gi 1730111  154 CSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC 188
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
505-547 4.57e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.38  E-value: 4.57e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1730111     505 HVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKR 547
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
276-312 4.83e-11

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 4.83e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1730111    276 RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
71-103 3.63e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 3.63e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730111      71 TCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDE 103
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
192-224 2.58e-09

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.02  E-value: 2.58e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1730111    192 TCGAHEFQCSTSSCIPISWVCDDDADCSDQSDE 224
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
592-634 7.04e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.22  E-value: 7.04e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1730111     592 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDR 634
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
111-149 9.68e-09

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.48  E-value: 9.68e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1730111    111 RTCRIHEISCgaHSTQCIPVSWRCDGENDCDSGEDEENC 149
Cdd:pfam00057   1 STCSPNEFQC--GSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
481-522 1.10e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 1.10e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1730111    481 QKLFWADLSQKA-IFSASIDDKVgRHVKMIDNVYNPAAIAVDW 522
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSD-RKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
655-695 7.73e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 7.73e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1730111    655 DRVYWIDGENEAVYGANKFTGSELATLV-NNLNDAQDIIVYH 695
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
320-350 1.90e-07

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.01  E-value: 1.90e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1730111    320 GPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
360-394 2.91e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.24  E-value: 2.91e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1730111    360 CLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTC 394
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
396-426 7.47e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 7.47e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730111     396 DIDECQNPGICSQ--ICINLKGGYKCECSRGYQ 426
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
706-749 2.71e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.15  E-value: 2.71e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1730111    706 CEEDmeNGGCEYLCLPAPQindhspKYTCSCPSGYNVEENGRDC 749
Cdd:pfam14670   1 CSVN--NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
568-608 1.69e-15

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 71.04  E-value: 1.69e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1730111    568 GFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLD 608
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
237-273 1.76e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 62.27  E-value: 1.76e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1730111    237 TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 273
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
33-67 2.51e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.51e-11
                        10        20        30
                ....*....|....*....|....*....|....*
gi 1730111   33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC 67
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
154-188 2.64e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.64e-11
                        10        20        30
                ....*....|....*....|....*....|....*
gi 1730111  154 CSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC 188
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
239-273 2.66e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.66e-11
                        10        20        30
                ....*....|....*....|....*....|....*
gi 1730111  239 CPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 273
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
153-188 3.08e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.80  E-value: 3.08e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1730111    153 TCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC 188
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
505-547 4.57e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.38  E-value: 4.57e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1730111     505 HVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKR 547
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
276-312 4.83e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 4.83e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1730111    276 RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
32-67 7.35e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 7.35e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1730111     32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC 67
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
527-565 8.19e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 8.19e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1730111    527 IYWTDAASK-TISVATLDGTKRKFLFNSDLREPASIAVDP 565
Cdd:pfam00058   3 LYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
153-185 2.08e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.10  E-value: 2.08e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730111     153 TCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDE 185
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
71-103 3.63e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 3.63e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730111      71 TCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDE 103
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
72-103 9.53e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.52  E-value: 9.53e-10
                        10        20        30
                ....*....|....*....|....*....|..
gi 1730111   72 CAESDFVCNNGQCVPSRWKCDGDPDCEDGSDE 103
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
238-270 1.01e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 1.01e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730111     238 KCPASEIQCGSGECIHKKWRCDGDPDCKDGSDE 270
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
70-103 1.20e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.18  E-value: 1.20e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1730111     70 KTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDE 103
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
32-64 1.86e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 1.86e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730111      32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDE 64
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
550-591 2.01e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.76  E-value: 2.01e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1730111     550 LFNSDLREPASIAVDPLSGFVYWSDWGEPaKIEKAGMNGFDR 591
Cdd:smart00135   3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
192-224 2.58e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.02  E-value: 2.58e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1730111    192 TCGAHEFQCSTSSCIPISWVCDDDADCSDQSDE 224
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
278-312 3.08e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 3.08e-09
                        10        20        30
                ....*....|....*....|....*....|....*
gi 1730111  278 CRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
192-224 4.03e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 4.03e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730111     192 TCGAHEFQCSTSSCIPISWVCDDDADCSDQSDE 224
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
592-634 7.04e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.22  E-value: 7.04e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1730111     592 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDR 634
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
111-149 9.68e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.48  E-value: 9.68e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1730111    111 RTCRIHEISCgaHSTQCIPVSWRCDGENDCDSGEDEENC 149
Cdd:pfam00057   1 STCSPNEFQC--GSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
481-522 1.10e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 1.10e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1730111    481 QKLFWADLSQKA-IFSASIDDKVgRHVKMIDNVYNPAAIAVDW 522
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSD-RKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
193-224 4.00e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 4.00e-08
                        10        20        30
                ....*....|....*....|....*....|..
gi 1730111  193 CGAHEFQCSTSSCIPISWVCDDDADCSDQSDE 224
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
277-309 6.30e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 6.30e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730111     277 TCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDE 309
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
655-695 7.73e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 7.73e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1730111    655 DRVYWIDGENEAVYGANKFTGSELATLV-NNLNDAQDIIVYH 695
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
613-654 1.21e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 1.21e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1730111    613 RLYWLDSKLH-MLSSVDLNGQDRRIVLKSLefLAHPLALTIFE 654
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDD--LQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
320-350 1.90e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.01  E-value: 1.90e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1730111    320 GPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
360-394 2.91e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.24  E-value: 2.91e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1730111    360 CLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTC 394
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
113-149 2.09e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.89  E-value: 2.09e-06
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 1730111  113 CRIHEISCGahSTQCIPVSWRCDGENDCDSGEDEENC 149
Cdd:cd00112   1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
320-350 2.90e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.55  E-value: 2.90e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1730111     320 GPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
320-350 3.23e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.50  E-value: 3.23e-06
                        10        20        30
                ....*....|....*....|....*....|.
gi 1730111  320 GPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Cdd:cd00112   2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
396-426 7.47e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 7.47e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730111     396 DIDECQNPGICSQ--ICINLKGGYKCECSRGYQ 426
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
475-615 1.38e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.38  E-value: 1.38e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730111  475 DADIAAQKLFWADLSQKAIfsASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVatLDGTKRKFLFNSD 554
Cdd:COG3391  74 DAGADGRRLYVANSGSGRV--SVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIP 149
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1730111  555 L-REPASIAVDPLSGFVYWSDWGEP------AKIEKAGMNgfdrrplVTADI---QWPNGITLDLIKSRLY 615
Cdd:COG3391 150 VgAGPHGIAVDPDGKRLYVANSGSNtvsvivSVIDTATGK-------VVATIpvgGGPVGVAVSPDGRRLY 213
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
396-426 3.34e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 3.34e-05
                        10        20        30
                ....*....|....*....|....*....|...
gi 1730111  396 DIDECQNPGICS--QICINLKGGYKCECSRGYQ 426
Cdd:cd00054   1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
112-146 6.44e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 40.69  E-value: 6.44e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1730111     112 TCRIHEISCGahSTQCIPVSWRCDGENDCDSGEDE 146
Cdd:smart00192   1 TCPPGEFQCD--NGRCIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
706-749 2.71e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.15  E-value: 2.71e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1730111    706 CEEDmeNGGCEYLCLPAPQindhspKYTCSCPSGYNVEENGRDC 749
Cdd:pfam14670   1 CSVN--NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
471-574 6.84e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 42.57  E-value: 6.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730111  471 TVALDADiaaQKLFWADLSQKAIFsasIDDKVGRHVKMIDN-----VYNPAAIAVDwVYKTIYWTDAASKTISVATLDGT 545
Cdd:cd14962  16 GVAADGR---GRIYVADTGRGAVF---VFDLPNGKVFVIGNagpnrFVSPIGVAID-ANGNLYVSDAELGKVFVFDRDGK 88
                        90       100       110
                ....*....|....*....|....*....|
gi 1730111  546 KRKFLFNSDLRE-PASIAVDPLSGFVYWSD 574
Cdd:cd14962  89 FLRAIGAGALFKrPTGIAVDPAGKRLYVVD 118
EGF_CA pfam07645
Calcium-binding EGF domain;
396-424 5.36e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 5.36e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1730111    396 DIDECQNPG-ICSQ--ICINLKGGYKCECSRG 424
Cdd:pfam07645   1 DVDECATGThNCPAntVCVNTIGSFECRCPDG 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
461-501 9.47e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 34.88  E-value: 9.47e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1730111     461 YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK 501
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
568-608 1.69e-15

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 71.04  E-value: 1.69e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1730111    568 GFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLD 608
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
237-273 1.76e-12

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 62.27  E-value: 1.76e-12
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1730111    237 TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 273
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
33-67 2.51e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.51e-11
                        10        20        30
                ....*....|....*....|....*....|....*
gi 1730111   33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC 67
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
154-188 2.64e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.64e-11
                        10        20        30
                ....*....|....*....|....*....|....*
gi 1730111  154 CSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC 188
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
239-273 2.66e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 2.66e-11
                        10        20        30
                ....*....|....*....|....*....|....*
gi 1730111  239 CPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNC 273
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
153-188 3.08e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.80  E-value: 3.08e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1730111    153 TCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC 188
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
505-547 4.57e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.38  E-value: 4.57e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1730111     505 HVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKR 547
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
276-312 4.83e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 4.83e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1730111    276 RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
32-67 7.35e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 7.35e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1730111     32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC 67
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
527-565 8.19e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 8.19e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1730111    527 IYWTDAASK-TISVATLDGTKRKFLFNSDLREPASIAVDP 565
Cdd:pfam00058   3 LYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
153-185 2.08e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.10  E-value: 2.08e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730111     153 TCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDE 185
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
71-103 3.63e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 3.63e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730111      71 TCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDE 103
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
72-103 9.53e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.52  E-value: 9.53e-10
                        10        20        30
                ....*....|....*....|....*....|..
gi 1730111   72 CAESDFVCNNGQCVPSRWKCDGDPDCEDGSDE 103
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
238-270 1.01e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 1.01e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730111     238 KCPASEIQCGSGECIHKKWRCDGDPDCKDGSDE 270
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
70-103 1.20e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.18  E-value: 1.20e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1730111     70 KTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDE 103
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
32-64 1.86e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 1.86e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730111      32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDE 64
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
550-591 2.01e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.76  E-value: 2.01e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1730111     550 LFNSDLREPASIAVDPLSGFVYWSDWGEPaKIEKAGMNGFDR 591
Cdd:smart00135   3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
192-224 2.58e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.02  E-value: 2.58e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1730111    192 TCGAHEFQCSTSSCIPISWVCDDDADCSDQSDE 224
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
278-312 3.08e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 3.08e-09
                        10        20        30
                ....*....|....*....|....*....|....*
gi 1730111  278 CRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
192-224 4.03e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 4.03e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730111     192 TCGAHEFQCSTSSCIPISWVCDDDADCSDQSDE 224
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
592-634 7.04e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.22  E-value: 7.04e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1730111     592 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDR 634
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
111-149 9.68e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.48  E-value: 9.68e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1730111    111 RTCRIHEISCgaHSTQCIPVSWRCDGENDCDSGEDEENC 149
Cdd:pfam00057   1 STCSPNEFQC--GSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
481-522 1.10e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 1.10e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1730111    481 QKLFWADLSQKA-IFSASIDDKVgRHVKMIDNVYNPAAIAVDW 522
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSD-RKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
193-224 4.00e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 4.00e-08
                        10        20        30
                ....*....|....*....|....*....|..
gi 1730111  193 CGAHEFQCSTSSCIPISWVCDDDADCSDQSDE 224
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
277-309 6.30e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 6.30e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730111     277 TCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDE 309
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
655-695 7.73e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 7.73e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1730111    655 DRVYWIDGENEAVYGANKFTGSELATLV-NNLNDAQDIIVYH 695
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
613-654 1.21e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 1.21e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1730111    613 RLYWLDSKLH-MLSSVDLNGQDRRIVLKSLefLAHPLALTIFE 654
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDD--LQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
320-350 1.90e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.01  E-value: 1.90e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1730111    320 GPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
360-394 2.91e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.24  E-value: 2.91e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1730111    360 CLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTC 394
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
113-149 2.09e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.89  E-value: 2.09e-06
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 1730111  113 CRIHEISCGahSTQCIPVSWRCDGENDCDSGEDEENC 149
Cdd:cd00112   1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
320-350 2.90e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.55  E-value: 2.90e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1730111     320 GPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Cdd:smart00192   3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
320-350 3.23e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.50  E-value: 3.23e-06
                        10        20        30
                ....*....|....*....|....*....|.
gi 1730111  320 GPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Cdd:cd00112   2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
396-426 7.47e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 7.47e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1730111     396 DIDECQNPGICSQ--ICINLKGGYKCECSRGYQ 426
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
475-615 1.38e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.38  E-value: 1.38e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730111  475 DADIAAQKLFWADLSQKAIfsASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVatLDGTKRKFLFNSD 554
Cdd:COG3391  74 DAGADGRRLYVANSGSGRV--SVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIP 149
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1730111  555 L-REPASIAVDPLSGFVYWSDWGEP------AKIEKAGMNgfdrrplVTADI---QWPNGITLDLIKSRLY 615
Cdd:COG3391 150 VgAGPHGIAVDPDGKRLYVANSGSNtvsvivSVIDTATGK-------VVATIpvgGGPVGVAVSPDGRRLY 213
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
396-426 3.34e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 3.34e-05
                        10        20        30
                ....*....|....*....|....*....|...
gi 1730111  396 DIDECQNPGICS--QICINLKGGYKCECSRGYQ 426
Cdd:cd00054   1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
525-672 3.67e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 46.23  E-value: 3.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730111  525 KTIYWTDAASKTISVatLDGTKRKFLFNSDL-REPASIAVDPLSGFVYWSDWGEPA--KIEKAGMNgfdrrplVTADIQ- 600
Cdd:COG3391  80 RRLYVANSGSGRVSV--IDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSGNGRvsVIDTATGK-------VVATIPv 150
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730111  601 --WPNGITLDLIKSRLYWLDSKLHMLS---SVdLNGQDRRiVLKSLEFLAHPLALTIFED--RVYWID-GENEAVYGANK 672
Cdd:COG3391 151 gaGPHGIAVDPDGKRLYVANSGSNTVSvivSV-IDTATGK-VVATIPVGGGPVGVAVSPDgrRLYVANrGSNTSNGGSNT 228
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
112-146 6.44e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 40.69  E-value: 6.44e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1730111     112 TCRIHEISCGahSTQCIPVSWRCDGENDCDSGEDE 146
Cdd:smart00192   1 TCPPGEFQCD--NGRCIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
706-749 2.71e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.15  E-value: 2.71e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1730111    706 CEEDmeNGGCEYLCLPAPQindhspKYTCSCPSGYNVEENGRDC 749
Cdd:pfam14670   1 CSVN--NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
443-576 3.46e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 3.46e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730111  443 LIFTNRRD--IRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSasIDDKVGRHVKMIDNVYNPAAIAV 520
Cdd:COG3391  82 LYVANSGSgrVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIPVGAGPHGIAV 159
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 1730111  521 DWVYKTIYWTDAASKTIS--VATLDGTKRKFLFNSDLRE-PASIAVDPLSGFVYWSDWG 576
Cdd:COG3391 160 DPDGKRLYVANSGSNTVSviVSVIDTATGKVVATIPVGGgPVGVAVSPDGRRLYVANRG 218
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
471-574 6.84e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 42.57  E-value: 6.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730111  471 TVALDADiaaQKLFWADLSQKAIFsasIDDKVGRHVKMIDN-----VYNPAAIAVDwVYKTIYWTDAASKTISVATLDGT 545
Cdd:cd14962  16 GVAADGR---GRIYVADTGRGAVF---VFDLPNGKVFVIGNagpnrFVSPIGVAID-ANGNLYVSDAELGKVFVFDRDGK 88
                        90       100       110
                ....*....|....*....|....*....|
gi 1730111  546 KRKFLFNSDLRE-PASIAVDPLSGFVYWSD 574
Cdd:cd14962  89 FLRAIGAGALFKrPTGIAVDPAGKRLYVVD 118
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
515-681 2.76e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 40.74  E-value: 2.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730111  515 PAAIAVDWVYKtIYWTDAASKTISVATLDGTKRKFLFNSDLRE----PASIAVDplSGFVYWSDWG---------EPAKI 581
Cdd:cd14963  58 PYGIAVDSDGN-IYVADLYNGRIQVFDPDGKFLKYFPEKKDRVklisPAGLAID--DGKLYVSDVKkhkvivfdlEGKLL 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1730111  582 EKAGMNGFDRrplvtADIQWPNGITLDLiKSRLYWLDSKLHMLSSVDLNGQDRRIVLKS---LEFLAHPLALTIFED-RV 657
Cdd:cd14963 135 LEFGKPGSEP-----GELSYPNGIAVDE-DGNIYVADSGNGRIQVFDKNGKFIKELNGSpdgKSGFVNPRGIAVDPDgNL 208
                       170       180
                ....*....|....*....|....
gi 1730111  658 YWIDGENEAVYGANKfTGSELATL 681
Cdd:cd14963 209 YVVDNLSHRVYVFDE-QGKELFTF 231
EGF_CA pfam07645
Calcium-binding EGF domain;
396-424 5.36e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 5.36e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1730111    396 DIDECQNPG-ICSQ--ICINLKGGYKCECSRG 424
Cdd:pfam07645   1 DVDECATGThNCPAntVCVNTIGSFECRCPDG 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
401-428 8.51e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 34.91  E-value: 8.51e-03
                          10        20
                  ....*....|....*....|....*...
gi 1730111    401 QNPGICSQICINLKGGYKCECSRGYQMD 428
Cdd:pfam14670   3 VNNGGCSHLCLNTPGGYTCSCPEGYELQ 30
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
461-501 9.47e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 34.88  E-value: 9.47e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1730111     461 YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK 501
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH