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Conserved domains on  [gi|3122602|sp|P97865|]
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RecName: Full=Peroxisomal targeting signal 2 receptor; Short=PTS2 receptor; AltName: Full=Peroxin-7

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 63-310 8.70e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 149.02  E-value: 8.70e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602   63 DGLFDVTWSeNNEHVLVTCSGDGSLQLWDTaKATGPLQVYKEHTQEVYSVDWSQTRgeQLVVSGSWDQTVKVWDPTVGNS 142
Cdd:cd00200  52 GPVRDVAAS-ADGTYLASGSSDKTIRLWDL-ETGECVRTLTGHTSYVSSVAFSPDG--RILSSSSRDKTIKVWDVETGKC 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602  143 LCTFRGHESVIYSTIWSPhiPGCF-ASASGDQTLRIWDVKTTGVRIVIPAHQTEILSCDWCKyNENLVVTGAVDCSLRGW 221
Cdd:cd00200 128 LTTLRGHTDWVNSVAFSP--DGTFvASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLW 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602  222 DLRNvRQPVFELLGHTYAIRRVKFSPfHASVLASCSYDFTVRFWNFSKPDPlLETVEHHTEFTCGLDLSlQSPTQVADCS 301
Cdd:cd00200 205 DLST-GKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGEC-VQTLSGHTNSVTSLAWS-PDGKRLASGS 280


                ....*....
gi 3122602  302 WDETIKIYD 310
Cdd:cd00200 281 ADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 63-310 8.70e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 149.02  E-value: 8.70e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602   63 DGLFDVTWSeNNEHVLVTCSGDGSLQLWDTaKATGPLQVYKEHTQEVYSVDWSQTRgeQLVVSGSWDQTVKVWDPTVGNS 142
Cdd:cd00200  52 GPVRDVAAS-ADGTYLASGSSDKTIRLWDL-ETGECVRTLTGHTSYVSSVAFSPDG--RILSSSSRDKTIKVWDVETGKC 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602  143 LCTFRGHESVIYSTIWSPhiPGCF-ASASGDQTLRIWDVKTTGVRIVIPAHQTEILSCDWCKyNENLVVTGAVDCSLRGW 221
Cdd:cd00200 128 LTTLRGHTDWVNSVAFSP--DGTFvASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLW 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602  222 DLRNvRQPVFELLGHTYAIRRVKFSPfHASVLASCSYDFTVRFWNFSKPDPlLETVEHHTEFTCGLDLSlQSPTQVADCS 301
Cdd:cd00200 205 DLST-GKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGEC-VQTLSGHTNSVTSLAWS-PDGKRLASGS 280


                ....*....
gi 3122602  302 WDETIKIYD 310
Cdd:cd00200 281 ADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
62-311 1.52e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 148.52  E-value: 1.52e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602   62 NDGLFDVTWSENNEHvLVTCSGDGSLQLWDTAKATgPLQVYKEHTQEVYSVDWSqtRGEQLVVSGSWDQTVKVWDPTVGN 141
Cdd:COG2319 162 SGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFS--PDGKLLASGSADGTVRLWDLATGK 237

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602  142 SLCTFRGHESVIYSTIWSP---HIpgcfASASGDQTLRIWDVKTTGVRIVIPAHQTEILSCDWCKyNENLVVTGAVDCSL 218
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPdgrLL----ASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTV 312

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602  219 RGWDLRNvRQPVFELLGHTYAIRRVKFSPfHASVLASCSYDFTVRFWNFSKPdPLLETVEHHTEFTCGLDLSLQSPTqVA 298
Cdd:COG2319 313 RLWDLAT-GKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATG-ELLRTLTGHTGAVTSVAFSPDGRT-LA 388

                       250
                ....*....|...
gi 3122602  299 DCSWDETIKIYDP 311
Cdd:COG2319 389 SGSADGTVRLWDL 401
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 111-268 9.56e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.88  E-value: 9.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602   111 SVDWSQTRGEQlVVSGSWDQTVKVWDPTVGNSLCTFRGHESVIYSTIWSPHIPGCFASASGDQTLRIWDVkTTGVRIVIP 190
Cdd:PLN00181 537 GICWNSYIKSQ-VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI-NQGVSIGTI 614

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3122602   191 AHQTEILSCDWCKYNENLVVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFspFHASVLASCSYDFTVRFWNFS 268
Cdd:PLN00181 615 KTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRF--VDSSTLVSSSTDNTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-136 1.13e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.13e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 3122602      98 PLQVYKEHTQEVYSVDWSQTrgEQLVVSGSWDQTVKVWD 136
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPD--GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
98-136 2.01e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.01e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 3122602     98 PLQVYKEHTQEVYSVDWSQTrgEQLVVSGSWDQTVKVWD 136
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPD--GKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 63-310 8.70e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 149.02  E-value: 8.70e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602   63 DGLFDVTWSeNNEHVLVTCSGDGSLQLWDTaKATGPLQVYKEHTQEVYSVDWSQTRgeQLVVSGSWDQTVKVWDPTVGNS 142
Cdd:cd00200  52 GPVRDVAAS-ADGTYLASGSSDKTIRLWDL-ETGECVRTLTGHTSYVSSVAFSPDG--RILSSSSRDKTIKVWDVETGKC 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602  143 LCTFRGHESVIYSTIWSPhiPGCF-ASASGDQTLRIWDVKTTGVRIVIPAHQTEILSCDWCKyNENLVVTGAVDCSLRGW 221
Cdd:cd00200 128 LTTLRGHTDWVNSVAFSP--DGTFvASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLW 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602  222 DLRNvRQPVFELLGHTYAIRRVKFSPfHASVLASCSYDFTVRFWNFSKPDPlLETVEHHTEFTCGLDLSlQSPTQVADCS 301
Cdd:cd00200 205 DLST-GKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGEC-VQTLSGHTNSVTSLAWS-PDGKRLASGS 280


                ....*....
gi 3122602  302 WDETIKIYD 310
Cdd:cd00200 281 ADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
62-311 1.52e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 148.52  E-value: 1.52e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602   62 NDGLFDVTWSENNEHvLVTCSGDGSLQLWDTAKATgPLQVYKEHTQEVYSVDWSqtRGEQLVVSGSWDQTVKVWDPTVGN 141
Cdd:COG2319 162 SGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFS--PDGKLLASGSADGTVRLWDLATGK 237

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602  142 SLCTFRGHESVIYSTIWSP---HIpgcfASASGDQTLRIWDVKTTGVRIVIPAHQTEILSCDWCKyNENLVVTGAVDCSL 218
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPdgrLL----ASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTV 312

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602  219 RGWDLRNvRQPVFELLGHTYAIRRVKFSPfHASVLASCSYDFTVRFWNFSKPdPLLETVEHHTEFTCGLDLSLQSPTqVA 298
Cdd:COG2319 313 RLWDLAT-GKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATG-ELLRTLTGHTGAVTSVAFSPDGRT-LA 388

                       250
                ....*....|...
gi 3122602  299 DCSWDETIKIYDP 311
Cdd:COG2319 389 SGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-266 1.73e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 145.56  E-value: 1.73e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602   62 NDGLFDVTWSeNNEHVLVTCSGDGSLQLWDTAKATgPLQVYKEHTQEVYSVDWSQTrgEQLVVSGSWDQTVKVWDPTVGN 141
Cdd:cd00200  93 TSYVSSVAFS-PDGRILSSSSRDKTIKVWDVETGK-CLTTLRGHTDWVNSVAFSPD--GTFVASSSQDGTIKLWDLRTGK 168

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602  142 SLCTFRGHESVIYSTIWSPhIPGCFASASGDQTLRIWDVKTTGVRIVIPAHQTEILSCDWCKyNENLVVTGAVDCSLRGW 221
Cdd:cd00200 169 CVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVW 246

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 3122602  222 DLRNvRQPVFELLGHTYAIRRVKFSPfHASVLASCSYDFTVRFWN 266
Cdd:cd00200 247 DLRT-GECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
3-311 6.03e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.98  E-value: 6.03e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602    3 AARTLRVPGRHGYAAEFSPYLPGRLACAAAQHYGIAGCGTLLVLDQNESGLQIFRSFDWNDGLFDVTWSENNEHVLVTCS 82
Cdd:COG2319  18 LALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602   83 GDGSLQLWDTAkATGPLQVYKEHTQEVYSVDWSqtRGEQLVVSGSWDQTVKVWDPTVGNSLCTFRGHESVIYSTIWSP-- 160
Cdd:COG2319  98 ADGTVRLWDLA-TGLLLRTLTGHTGAVRSVAFS--PDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPdg 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602  161 -HIpgcfASASGDQTLRIWDVKTTGVRIVIPAHQTEILSCDWCKyNENLVVTGAVDCSLRGWDLRNvRQPVFELLGHTYA 239
Cdd:COG2319 175 kLL----ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT-GKLLRTLTGHSGS 248

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3122602  240 IRRVKFSPfHASVLASCSYDFTVRFWNFSkPDPLLETVEHHTEFTCGLDLSLQSpTQVADCSWDETIKIYDP 311
Cdd:COG2319 249 VRSVAFSP-DGRLLASGSADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDG-KLLASGSDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 62-310 1.62e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.55  E-value: 1.62e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602   62 NDGLFDVTWSENNEHvLVTCSGDGSLQLWDTAKATgPLQVYKEHTQEVYSVDWSQTRgeQLVVSGSWDQTVKVWDPTVGN 141
Cdd:cd00200   9 TGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASADG--TYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602  142 SLCTFRGHESVIYSTIWSPHIPgCFASASGDQTLRIWDVKTTGVRIVIPAHQTEILSCDWCKYNeNLVVTGAVDCSLRGW 221
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQDGTIKLW 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602  222 DLRNVRqPVFELLGHTYAIRRVKFSPfHASVLASCSYDFTVRFWNFSKPDpLLETVEHHTEFTCGLDLSlQSPTQVADCS 301
Cdd:cd00200 163 DLRTGK-CVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGK-CLGTLRGHENGVNSVAFS-PDGYLLASGS 238


                ....*....
gi 3122602  302 WDETIKIYD 310
Cdd:cd00200 239 EDGTIRVWD 247
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 98-311 1.10e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.84  E-value: 1.10e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602   98 PLQVYKEHTQEVYSVDWSqtRGEQLVVSGSWDQTVKVWDPTVGNSLCTFRGHESVIYSTIWSPHIPgCFASASGDQTLRI 177
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFS--PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602  178 WDVKTTGVRIVIPAHQTEILSCDWCKYNEnLVVTGAVDCSLRGWDLRNvRQPVFELLGHTYAIRRVKFSPFHaSVLASCS 257
Cdd:cd00200  78 WDLETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPDG-TFVASSS 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 3122602  258 YDFTVRFWNFSKPdPLLETVEHHTEFTCGLDLSlQSPTQVADCSWDETIKIYDP 311
Cdd:cd00200 155 QDGTIKLWDLRTG-KCVATLTGHTGEVNSVAFS-PDGEKLLSSSSDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
5-225 1.15e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.85  E-value: 1.15e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602    5 RTLRVPGRHGYAAEFSPylPGR-LACAAAQhygiagcGTLLVLDQnESGLQIFRSFDWNDGLFDVTWSENNEHvLVTCSG 83
Cdd:COG2319 198 RTLTGHTGAVRSVAFSP--DGKlLASGSAD-------GTVRLWDL-ATGKLLRTLTGHSGSVRSVAFSPDGRL-LASGSA 266

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602   84 DGSLQLWDTAkaTG-PLQVYKEHTQEVYSVDWSqtRGEQLVVSGSWDQTVKVWDPTVGNSLCTFRGHESVIYSTIWSPHi 162
Cdd:COG2319 267 DGTVRLWDLA--TGeLLRTLTGHSGGVNSVAFS--PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD- 341

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3122602  163 PGCFASASGDQTLRIWDVKTTGVRIVIPAHQTEILSCDWcKYNENLVVTGAVDCSLRGWDLRN 225
Cdd:COG2319 342 GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF-SPDGRTLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 111-268 9.56e-12

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.88  E-value: 9.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602   111 SVDWSQTRGEQlVVSGSWDQTVKVWDPTVGNSLCTFRGHESVIYSTIWSPHIPGCFASASGDQTLRIWDVkTTGVRIVIP 190
Cdd:PLN00181 537 GICWNSYIKSQ-VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI-NQGVSIGTI 614

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3122602   191 AHQTEILSCDWCKYNENLVVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFspFHASVLASCSYDFTVRFWNFS 268
Cdd:PLN00181 615 KTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRF--VDSSTLVSSSTDNTLKLWDLS 690
PTZ00421 PTZ00421
coronin; Provisional
 65-230 1.19e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 56.05  E-value: 1.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602    65 LFDVTWSENNEHVLVTCSGDGSLQLWD------TAKATGPLQVYKEHTQEVYSVDWSQTRGEQLVVSGSwDQTVKVWDPT 138
Cdd:PTZ00421  78 IIDVAFNPFDPQKLFTASEDGTIMGWGipeeglTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGA-DMVVNVWDVE 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602   139 VGNSLCTFRGHESVIYSTIWSphIPGC-FASASGDQTLRIWDVKTTGVRIVIPAHQ-TEILSCDWCKyNENLVVTGAVDC 216
Cdd:PTZ00421 157 RGKAVEVIKCHSDQITSLEWN--LDGSlLCTTSKDKKLNIIDPRDGTIVSSVEAHAsAKSQRCLWAK-RKDLIITLGCSK 233

                        170
                 ....*....|....*...
gi 3122602   217 S----LRGWDLRNVRQPV 230
Cdd:PTZ00421 234 SqqrqIMLWDTRKMASPY 251
PTZ00421 PTZ00421
coronin; Provisional
 204-311 1.24e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.97  E-value: 1.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602   204 YNENLVVTGAVDCSLRGWDL------RNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKpDPLLETV 277
Cdd:PTZ00421  86 FDPQKLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER-GKAVEVI 164

                         90       100       110
                 ....*....|....*....|....*....|....
gi 3122602   278 EHHTEFTCGLDLSLQSpTQVADCSWDETIKIYDP 311
Cdd:PTZ00421 165 KCHSDQITSLEWNLDG-SLLCTTSKDKKLNIIDP 197
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-136 1.13e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.13e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 3122602      98 PLQVYKEHTQEVYSVDWSQTrgEQLVVSGSWDQTVKVWD 136
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPD--GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
98-136 2.01e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.01e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 3122602     98 PLQVYKEHTQEVYSVDWSQTrgEQLVVSGSWDQTVKVWD 136
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPD--GKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 229-271 1.85e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.10  E-value: 1.85e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 3122602   229 PVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPD 271
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHND 108
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 140-179 2.38e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.38e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 3122602     140 GNSLCTFRGHESVIYSTIWSPHIPgCFASASGDQTLRIWD 179
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 227-266 2.52e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.52e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 3122602     227 RQPVFELLGHTYAIRRVKFSPfHASVLASCSYDFTVRFWN 266
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
227-266 1.58e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.58e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 3122602    227 RQPVFELLGHTYAIRRVKFSPFHaSVLASCSYDFTVRFWN 266
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
140-179 3.64e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 3.64e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 3122602    140 GNSLCTFRGHESVIYSTIWSPHiPGCFASASGDQTLRIWD 179
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 98-190 7.00e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.09  E-value: 7.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602    98 PLQVYKEHTQEVYSVDWSQTRGEqLVVSGSWDQTVKVWD--------PTVGNSLCTFRGHESVIYSTIWSPHIPGCFASA 169
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPCFSE-ILASGSEDLTIRVWEiphndesvKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSS 144

                         90       100
                 ....*....|....*....|...
gi 3122602   170 SGDQTLRIWDVKTT--GVRIVIP 190
Cdd:PTZ00420 145 GFDSFVNIWDIENEkrAFQINMP 167
PTZ00420 PTZ00420
coronin; Provisional
 146-233 5.44e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 38.39  E-value: 5.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3122602   146 FRGHESVIYSTIWSPHIPGCFASASGDQTLRIWDVKTTGVRI--------VIPAHQTEILSCDWCKYNENLVVTGAVDCS 217
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVkeikdpqcILKGHKKKISIIDWNPMNYYIMCSSGFDSF 149

                         90
                 ....*....|....*.
gi 3122602   218 LRGWDLRNVRQpVFEL 233
Cdd:PTZ00420 150 VNIWDIENEKR-AFQI 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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