NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|3121773|sp|P91167|]
View 

RecName: Full=Probable actin-related protein 2/3 complex subunit 5; AltName: Full=Arp2/3 complex 16 kDa subunit; Short=p16-ARC

Protein Classification

actin-related protein 2/3 complex subunit 5 family protein( domain architecture ID 10520192)

actin-related protein 2/3 complex subunit 5 (ARPC5) family protein similar to ARPC5, a component of the Arp2/3 complex that mediates actin polymerization upon stimulation by nucleation-promoting factor

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
P16-Arc pfam04699
ARP2/3 complex 16 kDa subunit (p16-Arc); The Arp2/3 protein complex has been implicated in the ...
 5-144 1.05e-56

ARP2/3 complex 16 kDa subunit (p16-Arc); The Arp2/3 protein complex has been implicated in the control of actin polymerization. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3, and five others referred to as p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc. The precise function of p16-Arc is currently unknown. Its structure consists of a single domain containing a bundle of seven alpha helices.


:

Pssm-ID: 461399  Cd Length: 146  Bit Score: 173.47  E-value: 1.05e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3121773      5 DYKKYNVDIFHPAHFEDI-------QEESADCGPNVQEVRQFLESNRLEYALQSVLLNPPFGHSEQELKNRAVLLVAEVI 77
Cdd:pfam04699   1 DFRKIDIDAYDPDSFTEEdlypppsEVSLAEAQPLASQVRSLLSSGDAEGALKLALDNPPYGADEQAAKDLHLQTVLEVL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3121773     78 HAFRQTDIEESVHKLSNENGDILMKYIYKAMQLCSDSATCLsLLLWHSQLVSKFGQGSIVRVLSNRQ 144
Cdd:pfam04699  81 SSIKSSDITNIVKSLDSEQQDVLMKYLYKGMSLPSEKSGSV-LLSWHEKLVEVAGVGCIVRVLTDRR 146
 
Name Accession Description Interval E-value
P16-Arc pfam04699
ARP2/3 complex 16 kDa subunit (p16-Arc); The Arp2/3 protein complex has been implicated in the ...
 5-144 1.05e-56

ARP2/3 complex 16 kDa subunit (p16-Arc); The Arp2/3 protein complex has been implicated in the control of actin polymerization. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3, and five others referred to as p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc. The precise function of p16-Arc is currently unknown. Its structure consists of a single domain containing a bundle of seven alpha helices.


Pssm-ID: 461399  Cd Length: 146  Bit Score: 173.47  E-value: 1.05e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3121773      5 DYKKYNVDIFHPAHFEDI-------QEESADCGPNVQEVRQFLESNRLEYALQSVLLNPPFGHSEQELKNRAVLLVAEVI 77
Cdd:pfam04699   1 DFRKIDIDAYDPDSFTEEdlypppsEVSLAEAQPLASQVRSLLSSGDAEGALKLALDNPPYGADEQAAKDLHLQTVLEVL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3121773     78 HAFRQTDIEESVHKLSNENGDILMKYIYKAMQLCSDSATCLsLLLWHSQLVSKFGQGSIVRVLSNRQ 144
Cdd:pfam04699  81 SSIKSSDITNIVKSLDSEQQDVLMKYLYKGMSLPSEKSGSV-LLSWHEKLVEVAGVGCIVRVLTDRR 146
PX_YPT35 cd07280
The phosphoinositide binding Phox Homology domain of the fungal protein YPT35; The PX domain ...
 37-62 4.36e-03

The phosphoinositide binding Phox Homology domain of the fungal protein YPT35; The PX domain is a phosphoinositide (PI) binding module present in many proteins with diverse functions such as cell signaling, vesicular trafficking, protein sorting, and lipid modification, among others. This subfamily is composed of YPT35 proteins from the fungal subkingdom Dikarya. The PX domain is involved in targeting of proteins to PI-enriched membranes, and may also be involved in protein-protein interaction. The PX domain of YPT35 binds to phosphatidylinositol 3-phosphate (PI3P). It also serves as a protein interaction domain, binding to members of the Yip1p protein family, which localize to the ER and Golgi. YPT35 is mainly associated with endosomes and together with Yip1p proteins, may be involved in a specific function in the endocytic pathway.


Pssm-ID: 132813  Cd Length: 120  Bit Score: 35.00  E-value: 4.36e-03
                        10        20
                ....*....|....*....|....*...
gi 3121773   37 RQFLESNR--LEYALQSVLLNPPFGHSE 62
Cdd:cd07280  85 KAWLEKRRrgLQYFLNCVLLNPVFGGSP 112
 
Name Accession Description Interval E-value
P16-Arc pfam04699
ARP2/3 complex 16 kDa subunit (p16-Arc); The Arp2/3 protein complex has been implicated in the ...
 5-144 1.05e-56

ARP2/3 complex 16 kDa subunit (p16-Arc); The Arp2/3 protein complex has been implicated in the control of actin polymerization. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3, and five others referred to as p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc. The precise function of p16-Arc is currently unknown. Its structure consists of a single domain containing a bundle of seven alpha helices.


Pssm-ID: 461399  Cd Length: 146  Bit Score: 173.47  E-value: 1.05e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3121773      5 DYKKYNVDIFHPAHFEDI-------QEESADCGPNVQEVRQFLESNRLEYALQSVLLNPPFGHSEQELKNRAVLLVAEVI 77
Cdd:pfam04699   1 DFRKIDIDAYDPDSFTEEdlypppsEVSLAEAQPLASQVRSLLSSGDAEGALKLALDNPPYGADEQAAKDLHLQTVLEVL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3121773     78 HAFRQTDIEESVHKLSNENGDILMKYIYKAMQLCSDSATCLsLLLWHSQLVSKFGQGSIVRVLSNRQ 144
Cdd:pfam04699  81 SSIKSSDITNIVKSLDSEQQDVLMKYLYKGMSLPSEKSGSV-LLSWHEKLVEVAGVGCIVRVLTDRR 146
PX_YPT35 cd07280
The phosphoinositide binding Phox Homology domain of the fungal protein YPT35; The PX domain ...
 37-62 4.36e-03

The phosphoinositide binding Phox Homology domain of the fungal protein YPT35; The PX domain is a phosphoinositide (PI) binding module present in many proteins with diverse functions such as cell signaling, vesicular trafficking, protein sorting, and lipid modification, among others. This subfamily is composed of YPT35 proteins from the fungal subkingdom Dikarya. The PX domain is involved in targeting of proteins to PI-enriched membranes, and may also be involved in protein-protein interaction. The PX domain of YPT35 binds to phosphatidylinositol 3-phosphate (PI3P). It also serves as a protein interaction domain, binding to members of the Yip1p protein family, which localize to the ER and Golgi. YPT35 is mainly associated with endosomes and together with Yip1p proteins, may be involved in a specific function in the endocytic pathway.


Pssm-ID: 132813  Cd Length: 120  Bit Score: 35.00  E-value: 4.36e-03
                        10        20
                ....*....|....*....|....*...
gi 3121773   37 RQFLESNR--LEYALQSVLLNPPFGHSE 62
Cdd:cd07280  85 KAWLEKRRrgLQYFLNCVLLNPVFGGSP 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH