first galactose/rhamnose binding lectin domain found in Oncorhynchus keta CSL1-2, Silurus asotus RBL, Scomberomorus niphonius SML and similar proteins; The family includes a group of L-rhamnose-binding lectins, such as Oncorhynchus keta CSL1 and CSL2. CSL1 has hemagglutinating activity towards rabbit erythrocytes, but not human type B erythrocytes. CSL2 has hemagglutinating activity towards rabbit erythrocytes and human type B erythrocytes. Their hemagglutinating activities are inhibited by smooth-type lipopolysaccharide (LPS) from different bacterial species. The family also includes Silurus asotus rhamnose-binding lectin (RBL) and Scomberomorus niphonius L-rhamnose-binding lectin (SML). RBL, also known as Silurus asotus (catfish) roe lectin (SAL), is a lectin that binds L-rhamnose. It also binds monosaccharides possessing steric similarity to the hydroxyl group orientation at C2 and C4 of the pyranose ring structure of L-rhamnose, such as L-mannose and L-lyxose. RBL does not require a Ca2+ ion or free thiol group for its agglutination activity. SML is a rhamnose-binding lectin that also binds melibiose, raffinose, D-galactose, L-arabinose, D-fucose, maltose, and D-glucose with decreasing affinity. It does not bind D-arabinose, L-fucose, lactose, xylose or 2-deoxy-D-galactose. SML shows strong hemagglutinating activity against rabbit erythrocytes. CSL1-2 and SML contain two tandem galactose/rhamnose-binding lectin domains. RBL contains three galactose/rhamnose-binding lectin domains. This model corresponds to the first one.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706  93 KKVTTCEG--VVHLECGDGVVFLQKALYGRIDSQTCSQGRPQSQLTNTKCSQEGTLALWSQRCDGKQTCEVNMRVNQISD 170
Cdd:cd22833    1 ETVTTCDGnnVHRLSCDTGVINVQSALYGRTDSETCSEGRPPEQLTNTQCSQSGTLDLLKNRCDGKKVCELNTNDFRTSD 80

                         90
                 ....*....|....*..
gi 224487706 171 PCVGTYKYLDVTYICLP 187
Cdd:cd22833   81 PCPGTYKYLQTNYTCLP 97

first galactose/rhamnose binding lectin domain found in Oncorhynchus keta CSL1-2, Silurus asotus RBL, Scomberomorus niphonius SML and similar proteins; The family includes a group of L-rhamnose-binding lectins, such as Oncorhynchus keta CSL1 and CSL2. CSL1 has hemagglutinating activity towards rabbit erythrocytes, but not human type B erythrocytes. CSL2 has hemagglutinating activity towards rabbit erythrocytes and human type B erythrocytes. Their hemagglutinating activities are inhibited by smooth-type lipopolysaccharide (LPS) from different bacterial species. The family also includes Silurus asotus rhamnose-binding lectin (RBL) and Scomberomorus niphonius L-rhamnose-binding lectin (SML). RBL, also known as Silurus asotus (catfish) roe lectin (SAL), is a lectin that binds L-rhamnose. It also binds monosaccharides possessing steric similarity to the hydroxyl group orientation at C2 and C4 of the pyranose ring structure of L-rhamnose, such as L-mannose and L-lyxose. RBL does not require a Ca2+ ion or free thiol group for its agglutination activity. SML is a rhamnose-binding lectin that also binds melibiose, raffinose, D-galactose, L-arabinose, D-fucose, maltose, and D-glucose with decreasing affinity. It does not bind D-arabinose, L-fucose, lactose, xylose or 2-deoxy-D-galactose. SML shows strong hemagglutinating activity against rabbit erythrocytes. CSL1-2 and SML contain two tandem galactose/rhamnose-binding lectin domains. RBL contains three galactose/rhamnose-binding lectin domains. This model corresponds to the first one.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706  93 KKVTTCEG--VVHLECGDGVVFLQKALYGRIDSQTCSQGRPQSQLTNTKCSQEGTLALWSQRCDGKQTCEVNMRVNQISD 170
Cdd:cd22833    1 ETVTTCDGnnVHRLSCDTGVINVQSALYGRTDSETCSEGRPPEQLTNTQCSQSGTLDLLKNRCDGKKVCELNTNDFRTSD 80

                         90
                 ....*....|....*..
gi 224487706 171 PCVGTYKYLDVTYICLP 187
Cdd:cd22833   81 PCPGTYKYLQTNYTCLP 97

Galactose binding lectin domain;

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706  104 LECGDG-VVFLQKALYGRIDSQTCSqgrpqSQLTNTKCSQEGTLALWSQRCDGKQTCEVNMR-VNQISDPCVGTYKYLDV 181
Cdd:pfam02140   1 LSCPPGkVISILFASYGRPDGTTCP-----SFIQGTNCHSPNSLAIVSKACQGKNSCSVPASnSVFGGDPCPGTYKYLEV 75

                  ....
gi 224487706  182 TYIC 185
Cdd:pfam02140  76 EYKC 79

first galactose/rhamnose binding lectin domain found in Oncorhynchus keta CSL1-2, Silurus asotus RBL, Scomberomorus niphonius SML and similar proteins; The family includes a group of L-rhamnose-binding lectins, such as Oncorhynchus keta CSL1 and CSL2. CSL1 has hemagglutinating activity towards rabbit erythrocytes, but not human type B erythrocytes. CSL2 has hemagglutinating activity towards rabbit erythrocytes and human type B erythrocytes. Their hemagglutinating activities are inhibited by smooth-type lipopolysaccharide (LPS) from different bacterial species. The family also includes Silurus asotus rhamnose-binding lectin (RBL) and Scomberomorus niphonius L-rhamnose-binding lectin (SML). RBL, also known as Silurus asotus (catfish) roe lectin (SAL), is a lectin that binds L-rhamnose. It also binds monosaccharides possessing steric similarity to the hydroxyl group orientation at C2 and C4 of the pyranose ring structure of L-rhamnose, such as L-mannose and L-lyxose. RBL does not require a Ca2+ ion or free thiol group for its agglutination activity. SML is a rhamnose-binding lectin that also binds melibiose, raffinose, D-galactose, L-arabinose, D-fucose, maltose, and D-glucose with decreasing affinity. It does not bind D-arabinose, L-fucose, lactose, xylose or 2-deoxy-D-galactose. SML shows strong hemagglutinating activity against rabbit erythrocytes. CSL1-2 and SML contain two tandem galactose/rhamnose-binding lectin domains. RBL contains three galactose/rhamnose-binding lectin domains. This model corresponds to the first one.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706  93 KKVTTCEG--VVHLECGDGVVFLQKALYGRIDSQTCSQGRPQSQLTNTKCSQEGTLALWSQRCDGKQTCEVNMRVNQISD 170
Cdd:cd22833    1 ETVTTCDGnnVHRLSCDTGVINVQSALYGRTDSETCSEGRPPEQLTNTQCSQSGTLDLLKNRCDGKKVCELNTNDFRTSD 80

                         90
                 ....*....|....*..
gi 224487706 171 PCVGTYKYLDVTYICLP 187
Cdd:cd22833   81 PCPGTYKYLQTNYTCLP 97

galactose/rhamnose binding lectin domain found in Toxopneustes pileolus rhamnose-binding lectin SUL-I and similar proteins; SUL-I is a galactose/rhamnose-binding lectin with mitogenic, chemotactic, and cytotoxic activity. These activities can be triggered by binding of the lectin to specific carbohydrate chains on target cells. SUL-I may be involved in self-defense against invading microorganisms. SUL-I is composed of three distinctive domains with a folding structure similar to galactose/rhamnose-binding lectin domain found in proteins such as mammalian latrophilins, Oncorhynchus keta L-rhamnose-binding lectins (CSLs), and Silurus asotus rhamnose-binding lectin (SAL). The family also includes Heliocidaris crassispina D-galactoside-specific lectin, also known as sea urchin egg lectin or SUEL, and Echinometra lucunter L-rhamnose-binding lectin ELEL-1, both of which contain only one galactose/rhamnose-binding lectin domain. SUEL binds D-galactoside. It may play an important role in the activation of eggs triggered by fertilization, or in their subsequent differentiation. The dimeric form is essential for hemagglutination activity of SUEL. ELEL-1 is a rhamnose-binding lectin that also binds alpha-D-melibiose, alpha-D-lactose, beta-D-lactose, methyl-alpha-D-galactopyranoside, methyl-beta-D--galactopyranoside and D-galactose, but not D-arabinose, L-fucose, D-glucose, D-mannose, D-maltose, D-sucrose, N-acetyl-D-galactosamine, N-acetyl-D-glucosamine, N-acetyl-D-mannosamine-D-xylose, or by glycoproteins orosomucoid, thyroglobulin, ovomucoid and porcine stomach mucin. It shows cation-independent hemagglutinating activity against rabbit and human erythrocytes. ELEL-1 agglutinates cells of Gram-positive bacterial species S. aureus but not those of Gram-negative E. coli.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706 192 ITCEGSTSSLDCGKG-VIKVFHANYGRRDGSTCsaGRHELSNQNCLQPKTLDVVKQWCEGKSQCTLGL-DPVFGDPCFGT 269
Cdd:cd22827    2 RVCEGQTLTISCPAGkVIDIVSANYGRTDSSTC--PSGGIKNTNCRASNSLSIVRNRCNGKRSCSVKAsNSVFGDPCVGT 79

                         90
                 ....*....|
gi 224487706 270 YKYLEVSYTC 279
Cdd:cd22827   80 YKYLEVRYRC 89

first and second galactose/rhamnose binding lectin domain found in Oncorhynchus keta L-rhamnose-binding lectin CSL3 and similar proteins; The family includes a group of L-rhamnose-binding lectins, such as Oncorhynchus keta CSL1-3. CSL1 has hemagglutinating activity towards rabbit erythrocytes, but not human type B erythrocytes. CSL2 has hemagglutinating activity towards rabbit erythrocytes and human type B erythrocytes. CSL3 has hemagglutinating activity towards rabbit erythrocytes, human type A erythrocytes, human type B erythrocytes, human type O erythrocytes, and sheep erythrocytes. Their hemagglutinating activities are inhibited by smooth-type lipopolysaccharide (LPS) from different bacterial species. Members in this family contain two tandem galactose-binding lectin domains. This model corresponds to the first and second galactose/rhamnose-binding lectin domains found in Oncorhynchus keta CSL3, as well as the second galactose/rhamnose-binding lectin domain found in Oncorhynchus keta CSL2.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706 189 KTSITCEGSTSSLDCGKGVIKVFHANYGRRDGSTCSAGR--HELSNQNCLQPKTLDVVKQWCEGKSQCTL-GLDPVFGDP 265
Cdd:cd22832    1 ASSITCEGSDAQLDCDGGKIRIQRANYGRRDHDVCSIGRpaNQLTNTNCLSQSTTSKMAERCDGKSQCIVpASNSVFGDP 80

                         90
                 ....*....|....
gi 224487706 266 CFGTYKYLEVSYTC 279
Cdd:cd22832   81 CVGTYKYLDVAYTC 94

second galactose/rhamnose binding lectin domain found in Scomberomorus niphonius L-rhamnose-binding lectin (SML) and similar proteins; SML is a rhamnose-binding lectin that also binds melibiose, raffinose, D-galactose, L-arabinose, D-fucose, maltose and D-glucose with decreasing affinity. It does not bind D-arabinose, L-fucose, lactose, xylose or 2-deoxy-D-galactose. SML shows strong hemagglutinating activity against rabbit erythrocytes. SML contains two tandem galactose/rhamnose-binding lectin domains. This model corresponds to the second one.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706 190 TSITCEGSTSSLDCGKG-VIKVFHANYGRRDGSTCSAGR--HELSNQNCLQPKtlDVVKQWCEGKSQCTL-GLDPVFGDP 265
Cdd:cd22835    1 HLVACEGSLAHLKCDEGqVISVYGADYGRRDKTTCSFGRppSQIQNVECSNPT--DKVAERCNGKNSCSIkASNSVFGDP 78

                         90
                 ....*....|....
gi 224487706 266 CFGTYKYLEVSYTC 279
Cdd:cd22835   79 CVGTYKYLEVAYTC 92

first galactose/rhamnose binding lectin domain found in Oncorhynchus keta CSL1-2, Silurus asotus RBL, Scomberomorus niphonius SML and similar proteins; The family includes a group of L-rhamnose-binding lectins, such as Oncorhynchus keta CSL1 and CSL2. CSL1 has hemagglutinating activity towards rabbit erythrocytes, but not human type B erythrocytes. CSL2 has hemagglutinating activity towards rabbit erythrocytes and human type B erythrocytes. Their hemagglutinating activities are inhibited by smooth-type lipopolysaccharide (LPS) from different bacterial species. The family also includes Silurus asotus rhamnose-binding lectin (RBL) and Scomberomorus niphonius L-rhamnose-binding lectin (SML). RBL, also known as Silurus asotus (catfish) roe lectin (SAL), is a lectin that binds L-rhamnose. It also binds monosaccharides possessing steric similarity to the hydroxyl group orientation at C2 and C4 of the pyranose ring structure of L-rhamnose, such as L-mannose and L-lyxose. RBL does not require a Ca2+ ion or free thiol group for its agglutination activity. SML is a rhamnose-binding lectin that also binds melibiose, raffinose, D-galactose, L-arabinose, D-fucose, maltose, and D-glucose with decreasing affinity. It does not bind D-arabinose, L-fucose, lactose, xylose or 2-deoxy-D-galactose. SML shows strong hemagglutinating activity against rabbit erythrocytes. CSL1-2 and SML contain two tandem galactose/rhamnose-binding lectin domains. RBL contains three galactose/rhamnose-binding lectin domains. This model corresponds to the first one.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706 189 KTSITCEG-STSSLDCGKGVIKVFHANYGRRDGSTCSAGR--HELSNQNCLQPKTLDVVKQWCEGKSQCTLGLDPV-FGD 264
Cdd:cd22833    1 ETVTTCDGnNVHRLSCDTGVINVQSALYGRTDSETCSEGRppEQLTNTQCSQSGTLDLLKNRCDGKKVCELNTNDFrTSD 80

                         90
                 ....*....|....*.
gi 224487706 265 PCFGTYKYLEVSYTCL 280
Cdd:cd22833   81 PCPGTYKYLQTNYTCL 96

galactose/rhamnose binding lectin domain found in latrophilins; Latrophilins, also called lectomedins or latrotoxin receptors, belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: latrophilin-1 (LPHN1), Latrophilin-2 (LPHN2), and Latrophilin-3 (LPHN3). The LPHN1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. LPHN2 and LPHN3, although sharing strong sequence homology to LPHN1, do not bind alpha-latrotoxin. While LPHN3 is also brain specific, LPHN2, is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. All members in this family contain a galactose/rhamnose-binding lectin domain at N-terminus.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706 189 KTSITCEGSTSSLDC-GKGVIKVFHANYGRRDGSTCsAGRHELSNQNCLQPKTLDVVKQWCEGKSQCTLGLDP-VFGDPC 266
Cdd:cd22826    1 KREIACEGYKIRLRCpGSDVIMIESANYGRTDSSTC-PSDPNMTDTNCYLPDALAIVSQRCNNRTRCNVRADSsFFPDPC 79

                         90
                 ....*....|...
gi 224487706 267 FGTYKYLEVSYTC 279
Cdd:cd22826   80 PGTFKYLEVIYEC 92

galactose/rhamnose binding lectin domain found in Drosophila melanogaster Latrophilin Cirl and similar proteins; Latrophilin Cirl (calcium-independent receptor for latrotoxin) is an adhesion-type G-protein-coupled receptor (aGPCR) that acts as a molecular sensor and signal transducer that detects and converts mechanical stimuli into a metabotropic response. It functions in mechanosensory neurons by modulating ionotropic receptor currents, the initiating step of cellular mechanosensation. The model corresponds to a galactose/rhamnose-binding lectin domain found at the N-terminus of Latrophilin Cirl.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706 190 TSITCEGSTSSLDCGKG-VIKVFHANYGRRDGSTCSAGRHELSNQNCLQPKTLDVVKQWCEGKSQCTLGLD-PVFGDPCF 267
Cdd:cd22830    1 TAYACEGSQLTLECEDGtVIRIIRANYGRFSIAICNDHGNTDWSVNCMSPRSLRVVQERCDGKRSCSIPASsSVFGDPCP 80

                         90
                 ....*....|..
gi 224487706 268 GTYKYLEVSYTC 279
Cdd:cd22830   81 GTPKYLEVHYQC 92

galactose/rhamnose binding lectin domain found in Toxopneustes pileolus rhamnose-binding lectin SUL-I and similar proteins; SUL-I is a galactose/rhamnose-binding lectin with mitogenic, chemotactic, and cytotoxic activity. These activities can be triggered by binding of the lectin to specific carbohydrate chains on target cells. SUL-I may be involved in self-defense against invading microorganisms. SUL-I is composed of three distinctive domains with a folding structure similar to galactose/rhamnose-binding lectin domain found in proteins such as mammalian latrophilins, Oncorhynchus keta L-rhamnose-binding lectins (CSLs), and Silurus asotus rhamnose-binding lectin (SAL). The family also includes Heliocidaris crassispina D-galactoside-specific lectin, also known as sea urchin egg lectin or SUEL, and Echinometra lucunter L-rhamnose-binding lectin ELEL-1, both of which contain only one galactose/rhamnose-binding lectin domain. SUEL binds D-galactoside. It may play an important role in the activation of eggs triggered by fertilization, or in their subsequent differentiation. The dimeric form is essential for hemagglutination activity of SUEL. ELEL-1 is a rhamnose-binding lectin that also binds alpha-D-melibiose, alpha-D-lactose, beta-D-lactose, methyl-alpha-D-galactopyranoside, methyl-beta-D--galactopyranoside and D-galactose, but not D-arabinose, L-fucose, D-glucose, D-mannose, D-maltose, D-sucrose, N-acetyl-D-galactosamine, N-acetyl-D-glucosamine, N-acetyl-D-mannosamine-D-xylose, or by glycoproteins orosomucoid, thyroglobulin, ovomucoid and porcine stomach mucin. It shows cation-independent hemagglutinating activity against rabbit and human erythrocytes. ELEL-1 agglutinates cells of Gram-positive bacterial species S. aureus but not those of Gram-negative E. coli.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706  95 VTTCEG-VVHLECGDG-VVFLQKALYGRIDSQTCsqgrPQSQLTNTKCSQEGTLALWSQRCDGKQTCEVNMRVNQISDPC 172
Cdd:cd22827    1 KRVCEGqTLTISCPAGkVIDIVSANYGRTDSSTC----PSGGIKNTNCRASNSLSIVRNRCNGKRSCSVKASNSVFGDPC 76

                         90
                 ....*....|...
gi 224487706 173 VGTYKYLDVTYIC 185
Cdd:cd22827   77 VGTYKYLEVRYRC 89

Galactose binding lectin domain;

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706  201 LDCGKG-VIKVFHANYGRRDGSTCSagrHELSNQNCLQPKTLDVVKQWCEGKSQCTLGLDPVF--GDPCFGTYKYLEVSY 277
Cdd:pfam02140   1 LSCPPGkVISILFASYGRPDGTTCP---SFIQGTNCHSPNSLAIVSKACQGKNSCSVPASNSVfgGDPCPGTYKYLEVEY 77

                  ..
gi 224487706  278 TC 279
Cdd:pfam02140  78 KC 79

galactose/rhamnose binding lectin domain found in latrophilins; Latrophilins, also called lectomedins or latrotoxin receptors, belong to Group I adhesion GPCRs, which also include ETL (EGF-TM7-latrophilin-related protein). These receptors are a member of the adhesion family (subclass B2) that belongs to the class B GPCRs. Three subtypes of latrophilins have been identified: latrophilin-1 (LPHN1), Latrophilin-2 (LPHN2), and Latrophilin-3 (LPHN3). The LPHN1 is a brain-specific calcium-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. LPHN2 and LPHN3, although sharing strong sequence homology to LPHN1, do not bind alpha-latrotoxin. While LPHN3 is also brain specific, LPHN2, is ubiquitously distributed. The endogenous ligands for these two receptors are unknown. All members in this family contain a galactose/rhamnose-binding lectin domain at N-terminus.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706  98 CEG-VVHLEC-GDGVVFLQKALYGRIDSQTCSQGrpqSQLTNTKCSQEGTLALWSQRCDGKQTCEVNMRVNQISDPCVGT 175
Cdd:cd22826    6 CEGyKIRLRCpGSDVIMIESANYGRTDSSTCPSD---PNMTDTNCYLPDALAIVSQRCNNRTRCNVRADSSFFPDPCPGT 82

                         90
                 ....*....|
gi 224487706 176 YKYLDVTYIC 185
Cdd:cd22826   83 FKYLEVIYEC 92

third galactose/rhamnose binding lectin domain found in Silurus asotus rhamnose-binding lectin (RBL) and similar proteins; RBL, also known as Silurus asotus (catfish) roe lectin (SAL), is a lectin that binds L-rhamnose. It also binds monosaccharides possessing steric similarity to the hydroxyl group orientation at C2 and C4 of the pyranose ring structure of L-rhamnose, such as L-mannose and L-lyxose. RBL does not require a Ca2+ ion or free thiol group for its agglutination activity. RBL contains three galactose/rhamnose-binding lectin domains. This model corresponds to the third one.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706  95 VTTCEG-VVHLECGDGVVFLQKALYGRIDSQTCSQGRPqsqlTNTKCSQEgTLALWSQRCDGKQTCEVNMRVNQISDPCV 173
Cdd:cd22837    1 VIICENdSATITCSPETINVISAFYGRTDSTTCSHGRP----STTNCSSD-TLAYIRALCQGKQTCTLQASNSVFGDPCP 75

                         90
                 ....*....|..
gi 224487706 174 GTYKYLDVTYIC 185
Cdd:cd22837   76 GTYKYLRITYSC 87

galactose/rhamnose binding lectin domain found in latrophilin-1 and similar proteins; Latrophilin-1 (LPHN1), also called adhesion G protein-coupled receptor L1 (ADGRL1), or calcium-independent alpha-latrotoxin receptor 1 (CIRL-1), or lectomedin-2, is a brain-specific calcium-independent receptor that mediates the effect of alpha-latrotoxin, a potent presynaptic neurotoxin from the venom of the black widow spider that induces massive neurotransmitter release from sensory and motor neurons as well as endocrine cells, leading to nerve-terminal degeneration. This model corresponds to a galactose/rhamnose-binding lectin domain found at the N-terminus of LPHN1.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706 189 KTSITCEGSTSSLDC-GKGVIKVFHANYGRRDGSTCSAGRHELSNQNCLQPKTLDVVKQWCEGKSQCTL--GLDpVFGDP 265
Cdd:cd22844    2 RRELACEGYPIELRCpGSDVIMVENANYGRTDDKICDADPFQMENVQCYLPDAFKIMSQRCNNRTQCVVvaGSD-AFPDP 80

                         90
                 ....*....|....*
gi 224487706 266 CFGTYKYLEVSYTCL 280
Cdd:cd22844   81 CPGTYKYLEVQYDCV 95

second galactose/rhamnose binding lectin domain found in Caenorhabditis elegans protein EVA-1, human protein EVA-1 homolog C and similar proteins; The family includes Caenorhabditis elegans protein EVA-1 and its homologs, such as human protein EVA-1 homolog C (also known as C21orf63). EVA-1 functions as an UNC-40 coreceptor to enhance attraction to the MADD-4 guidance cue in C. elegans. It also acts as a receptor for slt-1 and is required for the guidance of the AVM pioneer axon to the ventral nerve cord. Human C21orf63 is a type-1 transmembrane heparin-binding protein. Members in this family contain two tandem galactose/rhamnose-binding lectin domains. This model corresponds to the second one. Due to the lack of rhamnose-binding key residues, the second galactose/rhamnose-binding domains of EVA-1 does not form a binding pocket for rhamnose.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706 189 KTSITCEGSTSSLDCGKG-VIKVFHANYGR--RDGSTCSAGRHELSNQNCLQPKTLDVVKQWCEGKSQCTLGLDP-VFGD 264
Cdd:cd22829    2 KSKVVCEGEKLRLSCKPSsRLAIYSASYGRtlEGSVECPSTPKGDPDEECLSDVALETVMKRCHGKRRCSLTADSeTFGD 81

                         90
                 ....*....|....*.
gi 224487706 265 PCF-GTYKYLEVSYTC 279
Cdd:cd22829   82 PCPpGVRKYLKVVYTC 97

galactose/rhamnose binding lectin domain found in Caenorhabditis elegans latrophilin-like protein 1 (LAT1) and similar proteins; LAT1 plays a role in the establishment of anterior-posterior polarity in tissues during embryogenesis. It is required for the alignment of the mitotic spindles and division planes. It may have a role in cell death events and play an essential role in normal defection and oocyte fertilization. LAT1 is involved in sperm function. it operates in pharyngeal pumping during feeding. LAT1 contains a galactose/rhamnose binding lectin domain at the N-terminus.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706 192 ITCEGSTSSLDCGKGVIKVFH-ANYGRRDGSTCSAGRHELSNQNCLQPKTLDVVKQWCEGKSQC--TLGLDPVFGDPCFG 268
Cdd:cd22839    5 IICEGDVANLSCPEGKYISIRlANYGRFSLGVCNPSNNIDLSTTCQNDKTLPILQKSCDGKSECsfVVSNKFFFEDPCPG 84

                         90
                 ....*....|.
gi 224487706 269 TYKYLEVSYTC 279
Cdd:cd22839   85 TPKYLEATYSC 95

galactose/rhamnose binding lectin domain found in Drosophila melanogaster Latrophilin Cirl and similar proteins; Latrophilin Cirl (calcium-independent receptor for latrotoxin) is an adhesion-type G-protein-coupled receptor (aGPCR) that acts as a molecular sensor and signal transducer that detects and converts mechanical stimuli into a metabotropic response. It functions in mechanosensory neurons by modulating ionotropic receptor currents, the initiating step of cellular mechanosensation. The model corresponds to a galactose/rhamnose-binding lectin domain found at the N-terminus of Latrophilin Cirl.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706  97 TCEG-VVHLECGDG-VVFLQKALYGRIDSQTCSqgrPQSQLT-NTKCSQEGTLALWSQRCDGKQTCEVNMRVNQISDPCV 173
Cdd:cd22830    4 ACEGsQLTLECEDGtVIRIIRANYGRFSIAICN---DHGNTDwSVNCMSPRSLRVVQERCDGKRSCSIPASSSVFGDPCP 80

                         90
                 ....*....|..
gi 224487706 174 GTYKYLDVTYIC 185
Cdd:cd22830   81 GTPKYLEVHYQC 92

galactose/rhamnose binding lectin domain found in latrophilin-2 and similar proteins; Latrophilin-2 (LPHN2), also called adhesion G protein-coupled receptor L2 (ADGRL2), or calcium-independent alpha-latrotoxin receptor 2 (CIRL-2), or latrophilin homolog 1 (LPHH1), or lectomedin-1, is ubiquitously distributed calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. It is probably implicated in the regulation of exocytosis. This model corresponds to a galactose/rhamnose-binding lectin domain found at the N-terminus of LPHN2.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706  93 KKVTTCEGV-VHLEC-GDGVVFLQKALYGRIDSQTCSQGrpQSQLTNTKCSQEGTLALWSQRCDGKQTCEVNMRVNQISD 170
Cdd:cd22845    2 RRELSCEGYpIDLRCpGSDVIMIESANYGRTDDKICDAD--PFQMENTDCYLPDAYKIMTQRCNNRTQCIVVTGSDVFPD 79

                         90
                 ....*....|....*..
gi 224487706 171 PCVGTYKYLDVTYICLP 187
Cdd:cd22845   80 PCPGTYKYLEVQYECVP 96

second galactose/rhamnose binding lectin domain found in Caenorhabditis elegans protein EVA-1, human protein EVA-1 homolog C and similar proteins; The family includes Caenorhabditis elegans protein EVA-1 and its homologs, such as human protein EVA-1 homolog C (also known as C21orf63). EVA-1 functions as an UNC-40 coreceptor to enhance attraction to the MADD-4 guidance cue in C. elegans. It also acts as a receptor for slt-1 and is required for the guidance of the AVM pioneer axon to the ventral nerve cord. Human C21orf63 is a type-1 transmembrane heparin-binding protein. Members in this family contain two tandem galactose/rhamnose-binding lectin domains. This model corresponds to the second one. Due to the lack of rhamnose-binding key residues, the second galactose/rhamnose-binding domains of EVA-1 does not form a binding pocket for rhamnose.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706  93 KKVTTCEG-VVHLECGDG-VVFLQKALYGRI--DSQTCSQgrPQSQLTNTKCSQEGTLALWSQRCDGKQTCEVNMRVNQI 168
Cdd:cd22829    2 KSKVVCEGeKLRLSCKPSsRLAIYSASYGRTleGSVECPS--TPKGDPDEECLSDVALETVMKRCHGKRRCSLTADSETF 79

                         90       100
                 ....*....|....*....|
gi 224487706 169 SDPCV-GTYKYLDVTYICLP 187
Cdd:cd22829   80 GDPCPpGVRKYLKVVYTCVP 99

galactose/rhamnose binding lectin domain found in Caenorhabditis elegans latrophilin-like protein 2 (LAT2) and similar proteins; LAT2 may have a role in pharyngeal pumping during feeding. It contains a galactose/rhamnose binding lectin domain at the N-terminal region. Due to the lack of rhamnose-binding key residues, the galactose/rhamnose-binding domains of LAT2 does not form a binding pocket for rhamnose. Therefore, LAT2 is unlikely to act as a rhamnose-binding lectin.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706 188 AKTSITCEGSTSSLDCGKG-VIKVFHANYGR-RDGSTCSaGRHELSNQNCLQPKTLDVVKQWCEGKSQCTLGLDP--VFG 263
Cdd:cd22840    1 ASSSVACEGDPFEISCPSGqRIKVDYASYGAiGTRSTCG-DSVSPAGETCSAPNSLQTMRQRCQGRQSCEIRVLNslFPN 79

                         90
                 ....*....|....*..
gi 224487706 264 DPCFGTY-KYLEVSYTC 279
Cdd:cd22840   80 DPCPGTSkKYLEYRYRC 96

galactose/rhamnose binding lectin domain found in plant beta-galactosidases and similar proteins; The family represents a group of plant beta-galactosidases (BGals), which belong to glycoside hydrolase family 35. They have a C-terminal domain homologous to animal galactose and rhamnose-binding lectins. BGals (EC 3.2.1.23), also called Exo-(1->4)-beta-D-galactanase, or lactase, catalyze hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. Some family members contain more than one galactose/rhamnose binding lectin domain. Due to the lack of rhamnose-binding key residues, the galactose/rhamnose-binding lectin domains of BGals do not form a binding pocket for rhamnose. Therefore, BGals are unlikely to act as rhamnose-binding lectins.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706 196 GSTSSLDCGKG-VI-KVFHANYGRRDGSTCSAgrhelSNQNCLQPKTLDVVKQWCEGKSQCTLGLDP--VFGDPCFGTYK 271
Cdd:cd22842    9 GSTLTLSCPAGqVIsSIDFASYGTPTGTCGSF-----SKGSCHAPNSLSVVEKACLGKNSCSIPASNsvFFGDPCPGTTK 83

                 ....*...
gi 224487706 272 YLEVSYTC 279
Cdd:cd22842   84 RLAVQATC 91

second galactose/rhamnose binding lectin domain found in Oncorhynchus keta CSL1 and similar proteins; The family includes a group of L-rhamnose-binding lectins, such as Oncorhynchus keta CSL1. CSL1 has hemagglutinating activity towards rabbit erythrocytes, but not human type B erythrocytes. Its hemagglutinating activity is inhibited by smooth-type lipopolysaccharide (LPS) from Klebsiella pneumoniae, Escherichia coli K-235, Shigella flexneri 1A, Aeromonas salmonicida and Salmonella minnesota and rough-type LPS from S. flexneri, but not by rough-type LPS from E. coli K12 and E. coli EH100. CSL1 agglutinates E. coli K12 and Bacillus subtilis. CSL1 contains two tandem galactose-binding lectin domains. This model corresponds to the second one.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706   4 RRFLTCGDP--SLQCDYGVIMVYGVQFSTIELS--SNERPKA------CSDTEAKNGPSNRCDGNEKCDVATSGSVCDLC 73
Cdd:cd22834    3 KTSITCEGSpvSLDCGPDVIKIYDANYGRRDSTtcSHGRPESqltntnCYLPETTKVMSERCNGKSLCDLLASNVVTDPC 82

                         90
                 ....*....|....*.
gi 224487706  74 nsaYLTNIFLDVTYGC 89
Cdd:cd22834   83 ---YGTYKYLEVSYSC 95

galactose/rhamnose binding lectin domain found in Hydra vulgaris nematogalectin and similar proteins; Nematogalectin, also called nemgal, is a nematocyst protein with an N-terminal GlyXY domain and a galactose/rhamnose binding lectin domain. There are two nematogalectins, A and B, in Hydra, and they are the products of alternative splicing. They are major components of the nematocyst tubule. Nematogalectin functions as a trimer that could bind to multiple chondroitin glycosaminoglycan molecules and stabilize the chondroitin proteoglycan layer.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 224487706 115 KALYGRIDSQTCsQGRPQSQLTNTKCSQ--EGTLALWSQRCDGKQTCEVnmRVNQI---SDPCVGTYKYLDVTYICLP 187
Cdd:cd22838   26 SAFWGRDDKKTC-PHPPPGLPSNKMCETdeENVKKKVNDQCQGEQACEV--VASNIffdDTICPDVYKYLKVKYECIP 100

galactose/rhamnose binding lectin-like domain found in Plasmodium falciparum P113 and similar proteins; P113 is an abundant glycosylphosphatidylinositol (GPI)-anchored merozoite surface protein that tethers the RH5:CyRPA:RIPR complex to the merozoite surface. The N-terminal region of P113 contains two closely interacting domains, which resemble the galactose/rhamnose-binding lectin domains found in proteins such as sea urchin egg lectin (SUEL), plant beta-galactosidases, mammalian latrophilins, and catfish rhamnose-binding lectin (SAL) eggs. Due to the lack of rhamnose-binding key residues, the galactose/rhamnose binding lectin-like domains of P113 do not form a binding pocket for rhamnose. Therefore, P113 is unlikely to act as a rhamnose-binding lectin. This model corresponds to galactose/rhamnose binding lectin-like domain of P113.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224487706 189 KTSITCEGSTSSLDC-GKGVIKVFHANYGRRDGSTCSAGRHELSNQNCLQPktldvVKQWCEGKSQCTL-GLDPVFGDPC 266
Cdd:cd22843    2 HTAFVCFGQEVTIHCpGDGNISIKSATYGYNNSNVCIYCNSFNCDKDITSP-----VNKKCCGKNTCVLtVSDILEGNPC 76

                         90
                 ....*....|...
gi 224487706 267 FGTYKYLEVSYTC 279
Cdd:cd22843   77 GIGNSYIRVVYTC 89