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Conserved domains on  [gi|48428578|sp|P61647|]
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RecName: Full=Alpha-2,8-sialyltransferase 8F; AltName: Full=Sialyltransferase 8F; Short=SIAT8-F; AltName: Full=Sialyltransferase St8Sia VI; Short=ST8SiaVI

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 19234068)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 120-392 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


:

Pssm-ID: 467719  Cd Length: 273  Bit Score: 541.27  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 120 EEYANFRAKLASCCDAVQNFVVSQNNTPVGTNMSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSL 199
Cdd:cd23991   1 EEHENFRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 200 CGTEIDKSDFVFRCNLPPTTGDVSKDVGSKTNLVTINPSIITLKYGNLKEKKALFLEDIATYGDAFFLLPAFSFRANTGT 279
Cdd:cd23991  81 CGAEIDQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 280 SFKVYYTLEESKARQKVLFFHPKYLKDLALFWRTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHY 359
Cdd:cd23991 161 SFKVYYTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHY 240

                       250       260       270
                ....*....|....*....|....*....|...
gi 48428578 360 YDNKLPKHGFHQMPKEYSQILQLHMKGILKLQF 392
Cdd:cd23991 241 YDNQLPKPGFHSMPKEFYQLLQLHSKGILKLQF 273
 
Name Accession Description Interval E-value
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 120-392 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 541.27  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 120 EEYANFRAKLASCCDAVQNFVVSQNNTPVGTNMSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSL 199
Cdd:cd23991   1 EEHENFRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 200 CGTEIDKSDFVFRCNLPPTTGDVSKDVGSKTNLVTINPSIITLKYGNLKEKKALFLEDIATYGDAFFLLPAFSFRANTGT 279
Cdd:cd23991  81 CGAEIDQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 280 SFKVYYTLEESKARQKVLFFHPKYLKDLALFWRTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHY 359
Cdd:cd23991 161 SFKVYYTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHY 240

                       250       260       270
                ....*....|....*....|....*....|...
gi 48428578 360 YDNKLPKHGFHQMPKEYSQILQLHMKGILKLQF 392
Cdd:cd23991 241 YDNQLPKPGFHSMPKEFYQLLQLHSKGILKLQF 273
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 140-387 9.27e-94

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 281.80  E-value: 9.27e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578   140 VVSQNNTPVGTNMSYEvESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTT 219
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578   220 GdVSKDVGSKTNLVTINP-SIITLKYGNLKEKKAL--FLEDIATY--GDAFFLLPAFSFRANTGTSFKVYYTLEESKARQ 294
Cdd:pfam00777  80 G-YEKDVGSKTTLRTMNPeSAIDSKYGNLGFSHPRdpFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578   295 ---KVLFFHPKYLKDLALFW-RTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKtveDIPVSHHYYDNKLPK---- 366
Cdd:pfam00777 159 dpdKVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLD---SRGNSHHYYDNVLMKkggf 235

                         250       260
                  ....*....|....*....|.
gi 48428578   367 HGFHQMPKEYSQILQLHMKGI 387
Cdd:pfam00777 236 YGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 120-392 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 541.27  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 120 EEYANFRAKLASCCDAVQNFVVSQNNTPVGTNMSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSL 199
Cdd:cd23991   1 EEHENFRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 200 CGTEIDKSDFVFRCNLPPTTGDVSKDVGSKTNLVTINPSIITLKYGNLKEKKALFLEDIATYGDAFFLLPAFSFRANTGT 279
Cdd:cd23991  81 CGAEIDQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 280 SFKVYYTLEESKARQKVLFFHPKYLKDLALFWRTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHY 359
Cdd:cd23991 161 SFKVYYTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHY 240

                       250       260       270
                ....*....|....*....|....*....|...
gi 48428578 360 YDNKLPKHGFHQMPKEYSQILQLHMKGILKLQF 392
Cdd:cd23991 241 YDNQLPKPGFHSMPKEFYQLLQLHSKGILKLQF 273
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 120-392 3.45e-173

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 484.07  E-value: 3.45e-173
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 120 EEYANFRAKLASCCDAVQNFVVSQNNTPVGTNMSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSL 199
Cdd:cd23971   1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 200 CGTEIDKSDFVFRCNLPPTTGdvSKDVGSKTNLVTINPSIITLKYGNLKEKKALFLEDIATYGDAFFLLPAFSFRANTGT 279
Cdd:cd23971  81 CGREIDSADFVIRCNLPPLND--SKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 280 SFKVYYTLEESKARQKVLFFHPKYLKDLALFWRTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHY 359
Cdd:cd23971 159 SLRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHY 238

                       250       260       270
                ....*....|....*....|....*....|...
gi 48428578 360 YDNKLPKHGFHQMPKEYSQILQLHMKGILKLQF 392
Cdd:cd23971 239 YDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 125-391 9.90e-107

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 315.23  E-value: 9.90e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 125 FRAKLASCCDAVQNFVVSQNNTPVGTNMSYEVESKKEIPIKKNIFHMFPVSQPFvDYPYNQCAVVGNGGILNKSLCGTEI 204
Cdd:cd23989   6 FRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPL-QLPLKKCSVVGNGGILKNSGCGQQI 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 205 DKSDFVFRCNLPPTTGDVSKDVGSKTNLVTINPSIITLKYGNLKEKKALFLEDIATYGDAFFLLPAFSFRANTGTSFKVY 284
Cdd:cd23989  85 DRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVY 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 285 YTLEESKARQKVLFFHPKYLKDLALFWRTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHYYDNKL 364
Cdd:cd23989 165 YTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDNVL 244

                       250       260
                ....*....|....*....|....*..
gi 48428578 365 PKHGFHQMPKEYSQILQLHMKGILKLQ 391
Cdd:cd23989 245 PDSGFHAMPEEFLQLWHLHKSGVLRMQ 271
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 120-390 3.25e-98

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 293.67  E-value: 3.25e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 120 EEYANFRAKLASCCDAVQNFVVSQNNTPVGTNMSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSL 199
Cdd:cd23990   1 TEANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 200 CGTEIDKSDFVFRCNLPPTTGDVSKDVGSKTNLVTINPSIITLKYGNLKEKKALFLEDIATYGDAFFLLPAFSFRANTGT 279
Cdd:cd23990  81 CGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 280 SFKVYYTLEESKARQKVLFFHPKYLKDLALFWRTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHY 359
Cdd:cd23990 161 SIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHY 240

                       250       260       270
                ....*....|....*....|....*....|.
gi 48428578 360 YDNKLPKHGFHQMPKEYSQILQLHMKGILKL 390
Cdd:cd23990 241 YDNVKPRPGFHAMPSEIFNFLHMHSRGILRV 271
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 125-391 4.28e-96

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 288.39  E-value: 4.28e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 125 FRAKLASCCDAvQNFVVSQNNTPVGTNMSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEI 204
Cdd:cd23963   6 FRKELERLLNT-RKLFLTQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCGKEI 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 205 DKSDFVFRCNLPPTTGDVsKDVGSKTNLVTINPSIITLKYGNLK--EKKALFLEDIATYGDAFFLLPAFSFRANTGTSFK 282
Cdd:cd23963  85 DSHDFVIRCNLPPIKGFE-KDVGRKTNLTTLNPSILKRRYNSLKknRDRDKFLNRLKEYNGSILWYPKFSFKSSTNLLLK 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 283 VYYTLEESKARQKVLFFHPKYLKDLALFWRTKGVTAyRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHYYDN 362
Cdd:cd23963 164 AARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGLEK-RPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPYHYYDD 242

                       250       260       270
                ....*....|....*....|....*....|.
gi 48428578 363 KLPK--HGFHQMPKEYSQILQLHMKGILKLQ 391
Cdd:cd23963 243 LSPStkNKVHNMPEEFKLLRELHKKGVLKLH 273
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 140-387 9.27e-94

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 281.80  E-value: 9.27e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578   140 VVSQNNTPVGTNMSYEvESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTT 219
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578   220 GdVSKDVGSKTNLVTINP-SIITLKYGNLKEKKAL--FLEDIATY--GDAFFLLPAFSFRANTGTSFKVYYTLEESKARQ 294
Cdd:pfam00777  80 G-YEKDVGSKTTLRTMNPeSAIDSKYGNLGFSHPRdpFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578   295 ---KVLFFHPKYLKDLALFW-RTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKtveDIPVSHHYYDNKLPK---- 366
Cdd:pfam00777 159 dpdKVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLD---SRGNSHHYYDNVLMKkggf 235

                         250       260
                  ....*....|....*....|.
gi 48428578   367 HGFHQMPKEYSQILQLHMKGI 387
Cdd:pfam00777 236 YGVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 120-390 3.88e-74

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 232.28  E-value: 3.88e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 120 EEYANFRAKLASCCDAVQNFVVSQNNTPVGTNMSYEVESKKEI-PIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKS 198
Cdd:cd23970   4 TALLHQRKEIRQYFDVIKNISLTKKDVRIGQLMHFDYSSHKYVfSISPNLRSLLPEVSPFQNKHYNTCAVVGNSGILTNS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 199 LCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSIITLKYGNLKEK--KALFLEDIATYGDAFFLLPAFSFRAN 276
Cdd:cd23970  84 QCGNEIDKSDFVFRCNFAPTEG-FEKDVGRKTNLTTFNPSILEKYYNNLLTIqdRNNFFLSLKKLDGAILWIPAFFFHTS 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 277 TGTSFKVYYTLEESKARQKV-LFFHPKYLKDLALFWRTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPV 355
Cdd:cd23970 163 ATVTRTLVDFFVEHRGQLKVqLAWPGNIMQHVNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPTGTPL 242

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 48428578 356 SHHYYDNKLPKHG-----FHQMPKEYSQILQLHMKGILKL 390
Cdd:cd23970 243 PYHYYDKKGTKFTtkwqeSHQLPAEFVLLYKMHGAGVLKL 282
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 134-391 3.50e-67

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 214.20  E-value: 3.50e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 134 DAVQNFVVSQNNTPVGTNMSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRC 213
Cdd:cd23969  15 DPEKDISVLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRC 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 214 NLPPTTGDVsKDVGSKTNLVTINPSIITLKYGNLKEK--KALFLEDIATYGDAFFLLPAFsfrANTGTSFKVYYTLE--- 288
Cdd:cd23969  95 NLAPVEGYE-KDVGTKSNLTTMNPSVIPHAYGDLVNAtdKEKFVERLRQLGDSILWIPAF---VSKGGEEHVQWTNEiil 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 289 ESKARQKVLFFHPKYLKDLALFWRTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHYYDNK--LPK 366
Cdd:cd23969 171 KHKLNVKTAYPPLRLNHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRAVKYHYYDNRkyLTT 250

                       250       260
                ....*....|....*....|....*
gi 48428578 367 HGFHQMPKEYSQILQLHMKGILKLQ 391
Cdd:cd23969 251 ARPHKMPEEFRALRSLHQRGALRLH 275
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 134-390 5.02e-50

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 169.75  E-value: 5.02e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 134 DAVQNFVVSQNNTPVGTNMSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRC 213
Cdd:cd23988  15 DAERDVSVVKSSFKPGDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRC 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 214 NLPPTTGdVSKDVGSKTNLVTINPSIITLKYGNLKEK--KALFLEDIATYGDAFFLLPAFSFRANTGTSFKVYYTLEESK 291
Cdd:cd23988  95 NLAPVVE-FAADVGTKSDFITMNPSVVQRAFGGFRNEsdREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNK 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 292 ARQKVLFFHPKYLKDLALFWRTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHYYDNKLPKH---- 367
Cdd:cd23988 174 LKVRTAYPSLRLIHAVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYHYYDDLKYRYfsna 253

                       250       260
                ....*....|....*....|...
gi 48428578 368 GFHQMPKEYSQILQLHMKGILKL 390
Cdd:cd23988 254 GPHRMPLEFKTLNVLHNRGALKL 276
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 126-390 6.20e-46

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 159.33  E-value: 6.20e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 126 RAKLASCCDAVQNFVVSQNNTPVGTNMSYEVESKKEIPIKKNIFHMFPVSQPFVDYPYNQCAVVGNGGILNKSLCGTEID 205
Cdd:cd23987   7 RKQILKFLDAERDISVLKGTLKPGDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREID 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 206 KSDFVFRCNLPPTTgDVSKDVGSKTNLVTINPSIITLKYGNL--KEKKALFLEDIATYGDAFFLLPAFSFRantGTSFKV 283
Cdd:cd23987  87 SHDFVIRCNLAPVE-EYAKDVGTKTDLVTMNPSVVQRAFEDLvnETWKEKFLQRLQSLNGSILWIPAFMAK---GGEERV 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 284 YYTLEES-KARQKVLFFHP--KYLKDLALFWRTKGVTAYRLSTGLMITSVAVELCKNVKLYGFWPFSKTVEDIPVSHHYY 360
Cdd:cd23987 163 EWVNDLIlKHHINVRTAYPslRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYHYY 242

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 48428578 361 DNKlpKHGF------HQMPKEYSQILQLHMKGILKL 390
Cdd:cd23987 243 DSL--KYGYtsqaspHTMPLEFKALKNLHQQGALKL 276
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 186-376 6.23e-28

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 108.60  E-value: 6.23e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 186 CAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSiITLKYGNLKEKKALFLEDiaTYGDAF 265
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKG-FEKDVGSKTTFRVLNSK-WAGFYLRGPRCGCHPLPL--EEEVVL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 266 FLlpafsFRANTGTSFKVYYTLEESKArqKVLFFHPKYLKDLALFWRT-------KGVTAYRLSTGLMITSVAVELCKNV 338
Cdd:cd19952  77 IL-----SRAAAADFKRLKRRKKRHDN--AVLLLTDPAPDLLSYVRKRleklglkSFFGGNAPSSGLLAVLLALQLCDSV 149

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 48428578 339 KLYGFWPFSKTVEDIPvsHHYYDNKLP--KHGFHQMPKEY 376
Cdd:cd19952 150 DLYGFGVDSGHAPKVP--YHYYDLVEAeeGTAVHSFDLEA 187
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 186-390 2.88e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 90.01  E-value: 2.88e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 186 CAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKT------------NLVTINPSIITLKYGNL--KEKK 251
Cdd:cd23964  85 CAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKG-FEKDVGTKTsfytffpeslhnSLLKHVPQDKDTKYLFIpfKIRD 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 252 ALFLEDIATYGDafflLPAFsfrantGTSFKVYYTLEESKAR-QKVLFFHPKYLKDLALFW-RTKgvTAYRLSTGLMITS 329
Cdd:cd23964 164 YDYLDAVLSGKP----VPDG------CDKGKRPPPLFGPKLNaTNVRLLHPDFIRYLFNRWlNSS--TSYRPTTGALMLL 231

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 48428578 330 VAVELCKNVKLYGF---WPFSKtvedipvshHYYDNK----LPKHGFHQMPKEYSQILQLHMKGILKL 390
Cdd:cd23964 232 TALHTCDQVSVYGFgydPRFSL---------HYYDKTfvkfTVFYANHDFTNERKLWRKLHEEGIINL 290
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 186-390 3.72e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 90.20  E-value: 3.72e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 186 CAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTInpSIITLK-----YGNL--------KEKKA 252
Cdd:cd23974  87 CAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKG-FEKDVGRRTSFYTF--STNTLMnslraYAGVgfngppqsKETRY 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 253 LFLEDiatYGDAFFLLPAfsfrANTGT--------SFKVYYTLEESKARQKVLFFHP---KYLKDLALFWR---TKGVTA 318
Cdd:cd23974 164 IFLPD---HDRDYLLVKA----ALTHTpidrgrdkSKRPSKYFGKDVTAEKFKIYHPdfiRYLRNRFLWSPilnTKQRDI 236

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 48428578 319 YRLSTGLMITSVAVELCKNVKLYGFwpfsKTVEDIPVSHHYYDNKLPKHGF---HQMPKEYSQILQLHMKGILKL 390
Cdd:cd23974 237 YRPSTGAVMLLAALHTCDQVSAYGF----MTPDYGKYSDHYYDKTYHKVVFyanHDLRLEMQLWQKLHKAGLIKL 307
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 152-390 3.65e-19

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 86.57  E-value: 3.65e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 152 MSYEV-------ESKKEIPIKKNIFHMFPVSQPFVDYPYN------QCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPT 218
Cdd:cd23966  33 LPPDVlkwwlslQSSKNSDLREVLEKLFQVVPGENPYRTRdpnrcrRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPT 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 219 TGdVSKDVGSKTNLVTINP-SIITLKYGN---LKEKKALFLEdiatygdafFLLPAFSfranTGTSFKVYYTLEES-KA- 292
Cdd:cd23966 113 KG-FEKDVGSKTTHHFMYPeSAVDLDPGVhlvLVPFKVLDLQ---------WLISALT----TGEITRTYTPVKRFiKAd 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 293 RQKVLFFHPKYLKDLALFWrTKGVTAYRlSTGLMITSVAVELCKNVKLYGF-------WpfsktvedipvsHHYYDNKLP 365
Cdd:cd23966 179 KDKVLVINPAFIKYVHDNW-TEHHGRYP-STGFLALIFALHICDEVSVFGFgadskgnW------------HHYWEKNRS 244

                       250       260       270
                ....*....|....*....|....*....|
gi 48428578 366 KHGF-----HQMPKEYSQILQLHMKGILKL 390
Cdd:cd23966 245 AGAFrktgvHDADFESDIIKKLAKEGKIRV 274
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 186-390 5.43e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 77.87  E-value: 5.43e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 186 CAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSIITLKYGNLKE------------KKAL 253
Cdd:cd23973  86 CAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKG-YEEDVGTRTSFYVHTAHSITSSLMILQKrgfknipqdkdiKYIL 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 254 FLEDIATYG--DAFFLLPAFSFRANTGTSFKVYYTleESKARQKVLFFHP---KYLKDlaLFWRTKGVTA-----YRLST 323
Cdd:cd23973 165 FPEGPRDYQwlEALLKNKTIPSGAYYGRRPRSYFS--GDFTEDKYLVLHPdflRYVKN--RFLRSKTLKGkywaiYRPTT 240

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 324 GLMITSVAVELCKNVKLYGFWpfskTVEDIPVSHHYYDNKLPKHGF---HQMPKEYSQILQLHMKGILKL 390
Cdd:cd23973 241 GAFLLLTALHLCDTVSAYGFI----TEDYRKYPDHYYDKKKTKLVFyinHDFRLEKKLWKRLHDEKIIKL 306
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 185-390 9.87e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 74.09  E-value: 9.87e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 185 QCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLV-----TINPSIITlkYGNL--------KEKK 251
Cdd:cd23972  84 RCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKG-FEEDVGTKTSFYgftvnTMKNSLIS--YWNLgftrtpqgQDLQ 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 252 ALFL-EDIATY---GDAFFLLPAFSfRANTGTSFKVYYTLEESKARQKVLffHP---KYLKDLAL---FWRTKGVTAYRL 321
Cdd:cd23972 161 YIFIpSDIRDYvmlRSAILGVPVPE-GLDKGDRPHKYFGPEASAKKFKLL--HPdfiSYLTDRFLkskLLNTHYGHLYMP 237

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 48428578 322 STGLMITSVAVELCKNVKLYGF-----WPFSKtvedipvshHYYDNK---LPKHGFHQMPKEYSQILQLHMKGILKL 390
Cdd:cd23972 238 STGALMLLTALHTCDQVSAYGFitsnyWKFSD---------HYYERKkkpLVFYANHDMLLEAALWRRLHKAGILQL 305
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 185-371 1.92e-14

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 72.99  E-value: 1.92e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 185 QCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSiitlKYGNLKEKKALFLEDIATYgDA 264
Cdd:cd23980  83 RCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEG-FEADVGSKTTHHFVYPE----SFRELAQNVSMILVPFKTL-DL 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 265 FFLLPAFSfranTGTSFKVYYTLEES-KARQ-KVLFFHPKYLKDLALFWrTKGVTAYRlSTGLMITSVAVELCKNVKLYG 342
Cdd:cd23980 157 EWVISATT----TGTISHTYVPVPRKiKVKKeKILIYHPAFIKYVFDRW-LQGHGRYP-STGILSVIFSLHVCDEVDLYG 230

                       170       180
                ....*....|....*....|....*....
gi 48428578 343 FWPFSKTvedipVSHHYYDNKLPKHGFHQ 371
Cdd:cd23980 231 FGADSKG-----NWHHYWENNPSAGAFRK 254
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 184-366 5.25e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 67.65  E-value: 5.25e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 184 NQCAVVGNGG-ILNKSLcGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNL-VTINPSIitlkyGNLKEKKALFLEDIATY 261
Cdd:cd23965   2 DTCALVSSSGqLLGSGA-GKEIDSADCVIRMNDAPTRG-YEKDVGRRTTIrVVSHSSL-----PRLLRNAILLLAGTRAP 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 262 GDAFFLLPAFSFRANTGTSFKVYYTLEESKARQKVLFFHP-KYLKDLALFWRTKGVTAYR----LSTGLMITSVAVELCK 336
Cdd:cd23965  75 TVVVFWGPETKMNKDGAGKYNLLRSLSKKYPDVEFYSLTPeKMDYADELFEKETGKSRIKsgtwLSTGWFTMLLALDVCD 154

                       170       180       190
                ....*....|....*....|....*....|..
gi 48428578 337 NVKLYGFWP--FSKTVEDIPVSHHYYDNKLPK 366
Cdd:cd23965 155 EIKVYGMVPenYCREHPNSKVPYHYYEPGGLK 186
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 168-384 5.41e-13

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 68.45  E-value: 5.41e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 168 IFHMFPVSQPFVDyPYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSIITL-KYGN 246
Cdd:cd23968  31 RYPFPESSLENTK-RYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKG-FEKDVGSKTTLRLINSQILSKpEFNF 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 247 LKEKK----ALFLEDIATYG---DAFFLLPAFSFrantgtsFKVYYTLEESKARQKVLFFHPKYLKDL------ALFWRT 313
Cdd:cd23968 109 LTDPLyrnvTLLVWDPSSYNvnlEKWYKKPDFDF-------FPNYIKYRRRHPEEPFYLIDPRFLWRLwdilqeYTPEKI 181

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 48428578 314 KGVTAyrlSTGLMITSVAVELCKNVKLYGFWPfskTVEDIPVShHYYD---NKLPKHG-FHqmPKEYSQILQLHM 384
Cdd:cd23968 182 KPNPP---SSGFIGIVLMLHLCDWVDVYEYVP---SVRQTDRC-HYYDvekDLACTLGaWH--PLAAEKLLVRHL 247
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 186-361 9.90e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 61.42  E-value: 9.90e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 186 CAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSIITLKYGNLKEkkalfLEDIaTYGDAF 265
Cdd:cd23976  18 CALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRG-YGKDVGNKTSLRVIAHSSIQRILRNRNE-----LLNV-SQGTVF 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 266 FLLPAFSFRANTGTSFkVYYTLEESK-----------ARQKVLFFHPKYLKDLAlfwRTKGVTAYRLSTGLMITSVAVEL 334
Cdd:cd23976  91 IFWGPSNYMRRDGKGL-VYNNLQLMNqilpklkvytiTRHKMLQFDELFKRETG---KDRKISNTWLSTGWFTMIIALEL 166

                       170       180
                ....*....|....*....|....*....
gi 48428578 335 CKNVKLYGFWP--FSKTVEDIPVSHHYYD 361
Cdd:cd23976 167 CDRINVYGMVPpdFCRDPNHPSVPYHYYE 195
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 186-366 1.54e-10

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 60.38  E-value: 1.54e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 186 CAVVGNGGIL-NKSLcGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPsiitlkygnlkekKALFLEDIATYGDA 264
Cdd:cd23967   5 CVVVGNGGVLkGKSL-GSVIDKYDVVIRMNDAPVKG-YEKDVGSKTTFRMFYP-------------ESAFRDPEEYDSDW 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 265 FFLLPAFSF-------------RANTGTSF--KVYYTLEesKARQKVLFFHPKYLKDLAL----FWRTKGVTAYRLSTGL 325
Cdd:cd23967  70 LLVLVPFKSmdllwlqavikgkKPNGKGGFwkKIATSVP--KPPKKIRILNPYILQEAAFdligLPMNGKQGKNVPTTGI 147

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 48428578 326 MITSVAVELCKNVKLYGF-WPFSKtvEDIPVshHYYDNKLPK 366
Cdd:cd23967 148 IAIVMALHYCDEVDIAGFgYDPSD--PNAPL--HYYDSLTMK 185
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 184-365 4.41e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 59.48  E-value: 4.41e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 184 NQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSIItlkYGNLKEKKAlFLEDIATYGD 263
Cdd:cd23978   2 HQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTG-YEKDVGNKTTLRVVAHSSV---YRVLRRPQE-FLNRTPETTL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 264 AFFLLPAFSFRANTGTSFKVYYTLEESKARQKVLFFHPKYLKDL-ALFWRTKGVTAYR----LSTGLMITSVAVELCKNV 338
Cdd:cd23978  77 IFWGPPNKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMRQFdDLFRGETGRDRKKshswLSTGWFTMVIAVELCDNV 156

                       170       180       190
                ....*....|....*....|....*....|
gi 48428578 339 KLYGFWPF---SKTVEDIPVSHHYYDNKLP 365
Cdd:cd23978 157 HVYGMVPPnycSKRPTPKKMPYHYYEPKGP 186
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 182-360 4.56e-10

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 59.72  E-value: 4.56e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 182 PYNQCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSIITL-KYGNLKEkkALFLE---- 256
Cdd:cd23985  44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAG-FQQDVGTKTTIRLINSQLVTTeKHKFLKD--SLYNEgili 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 257 --DIATY-GDA--FFLLPAFSFrantgtsFKVYYTLEESKARQKVLFFHPKYLKDLalfW-RTKGVTAYRL-----STGL 325
Cdd:cd23985 121 vwDPAPYhSDIpeWYKNPDYNF-------FENYKTYRRLNPNQPFYILHPQMQWEL---WdIIQENSPEEIqpnppSSGM 190

                       170       180       190
                ....*....|....*....|....*....|....*
gi 48428578 326 MITSVAVELCKNVKLYGFWPfSKTVEDIPvshHYY 360
Cdd:cd23985 191 LGIILMMTLCDQVDVYEFLP-SKRKTDVC---HYY 221
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 180-362 7.37e-10

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 59.50  E-value: 7.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 180 DYPYNQ--------CAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSiitlKYGNLKEKK 251
Cdd:cd23979  69 ENPYRSwdpsrcrrCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVG-FEADVGSRTTHHFMYPE----SAKNLPANV 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 252 ALFLEDIATYgDAFFLLPAFSfranTGtsfKVYYTLEESKA-----RQKVLFFHPKYLKDLALFWrTKGVTAYRlSTGLM 326
Cdd:cd23979 144 SFVLVPFKTL-DLLWITSALS----TG---QIRFTYAPVKQflrvdKDKVQIYNPAFFKYIHDRW-TEHHGRYP-STGML 213

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 48428578 327 ITSVAVELCKNVKLYGFWPFSKTvedipVSHHYYDN 362
Cdd:cd23979 214 VLFFALHVCDEVNVYGFGADSRG-----NWHHYWEN 244
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 185-382 2.75e-09

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 56.60  E-value: 2.75e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 185 QCAVVGNG-GILNKSLcGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSiiTLKYGNLKE--KKALFLEDIATY 261
Cdd:cd23982   4 RCVVVGNGhNLKNSSL-GDVIDSYDVVIRLNDAPVRG-FEKDVGSKTTIRLFYPE--SAQFDPGIEndPDTLLVLVPFKP 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 262 GDAFFLLPAFSFRANTGTSF--KVYYTLEESKARQKVLffHPKYLKDLALfwRTKGVTAYRL-----STGLMITSVAVEL 334
Cdd:cd23982  80 LDFYWLYEILSNEKRVRKGFwkQPPRIWDANPKQIRIL--NPYYTYVAAT--KLLQVPGQRKkkqkpTTGLLAITLALHL 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 48428578 335 CKNVKLYGF-WPFSkTVEDIPVshHYYDNKLPKH---GFHQMPKEYSQILQL 382
Cdd:cd23982 156 CDEVHIAGFgYPDN-GNSNQPI--HYYNQITLKSmanSGHNLNAEAQAIQRL 204
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 183-241 1.64e-08

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 55.23  E-value: 1.64e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 183 YNQCAVVGN-GGILNKSLcGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSIIT 241
Cdd:cd23986  49 FRSCAVVTSaGAILNSSL-GKEIDSHDAVLRFNSAPTRG-YEKDVGNKTTIRIINSQILT 106
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 185-255 4.82e-08

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 53.00  E-value: 4.82e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 48428578 185 QCAVVGNGGIL-NKSLcGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSIITLKYGNLkEKKALFL 255
Cdd:cd23981   4 RCIIVGNGGVLaNKSL-GSKIDDYDVVVRLNSAPVKG-FEKDVGSKTTLRITYPEGAIQKPEQY-EKDSLFV 72
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 182-362 2.99e-07

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 50.52  E-value: 2.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 182 PYNQCAVVGNGGIL-NKSLcGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNL-------VTINPS---------IITLKY 244
Cdd:cd23984   1 SCKKCVVVGNGGVLrNKSL-GKKIDSYDVIIRMNNGPVIG-YENDVGKRTTFrlcypesIFSDPShydpnttvvLIPFKP 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 245 GNLKEKKALFLED-IATYGdaFFLLPAfsfrantgtsFKVYYTLEE---------SKARQKVLFFHPKYLKDLALFWRTk 314
Cdd:cd23984  79 HDLRWLLDLLMGKkVSAKG--FWKKPA----------LNLIYKPNQirilnpfilRIAAYELLHFPKRFPKEKKPKHPT- 145

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 48428578 315 gvtayrlsTGLMITSVAVELCKNVKLYGF-WPFSktveDIPVSHHYYDN 362
Cdd:cd23984 146 --------TGIIAITLALHICNEVHIAGFkYDFS----NLNSTLHYYGN 182
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 185-361 4.22e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 47.55  E-value: 4.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 185 QCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSIITLkygnLKEKKALFLEDIAtygDA 264
Cdd:cd23977   3 RCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAG-YEADVGNRSSLRVVSHTSVPL----LLRNQGYFFQQSR---DT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 265 FFLL--PAFSF-RANTGTSFKVY------------YTLEESKARQKVLFFHPKYLKDlalfwRTKGVTAyrLSTGLMITS 329
Cdd:cd23977  75 KYVIwgPERNMdRDGGGKTYRALltlakmyphlqvYTLTEEKMAYCDGVFQNETGKN-----RMKSGSF--LSTGWFTMI 147

                       170       180       190
                ....*....|....*....|....*....|....
gi 48428578 330 VAVELCKNVKLYGFW--PFSKTVEDIPVSHHYYD 361
Cdd:cd23977 148 LALELCEEILVYGMVsdSYCRNKNHSSVPYHYYE 181
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 185-237 6.58e-06

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 46.66  E-value: 6.58e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 48428578 185 QCAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINP 237
Cdd:cd23983   4 RCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQG-YSQDVGNKTTIRMTYP 55
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 186-361 4.17e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 44.54  E-value: 4.17e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 186 CAVVGNGGILNKSLCGTEIDKSDFVFRCNLPPTTGdVSKDVGSKTNLVTINPSIITLKygnLKEKKALFLEDIATygdAF 265
Cdd:cd23975   4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKG-YEEDVGKRTTIRVVSHTSVPLL---LKNPDYFFKETNET---IY 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48428578 266 FLLPAFSFRANTGTSFkVYYTLE---ESKARQKVLFFHPKYLKDL-ALFWRTKG----VTAYRLSTGLMITSVAVELCKN 337
Cdd:cd23975  77 VIWGPFRNMRKDGKGI-VYNMLKkavESYPQAKIYVTTEKRMSYCdTVFKKETGkdrvQSGSYLSTGWFTLILAMDACYG 155

                       170       180
                ....*....|....*....|....*.
gi 48428578 338 VKLYGFW--PFSKTVEDIPVSHHYYD 361
Cdd:cd23975 156 IHVYGMIndTYCKTEGYRKVPYHYYE 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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