|
Name |
Accession |
Description |
Interval |
E-value |
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
1-806 |
0e+00 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 1319.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 1 MDFINIEKKWQEFWWKNKSFEPKDDFNLPKKYILSMLPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGM 80
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 81 PAENAAIKHGIHPKTWTYENIENMQKEFEALGFSFSKNREFATSDPDYTKFEQRFFIDLWEKGLIYRKKAMLNWCPNDKT 160
Cdd:TIGR00396 81 PAENAAIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 161 VLANEQVI-DGRCWRCDTEVIQKELYQYYLKITNYAEELLKDLEALeDHWPSQVLIMQKNWIGKSSGLQFGFKIADEclk 239
Cdd:TIGR00396 161 VLANEQVDsDGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEEL-DHWPESVKEMQRNWIGKSEGVEITFKIADH--- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 240 acngIQEIEVFTTRADTIYGVTYIAIAPEHPLVEHAIKQVsQEVSKMIKAILNTTQRERALE---KKGAFLGIYAIHPLT 316
Cdd:TIGR00396 237 ----DEKITVFTTRPDTIFGVTYLALAPEHPLVEKAAENN-PKVAAFIKKILNKTVAERTKAtkeKKGVDTGIKAIHPLT 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 317 KQKIPVWVANFALANYGSGALMGVPACDERDFEFANLYHIPIKVITQSP-QNLP----HTKEEVLKNSGEWSDLSSSVAR 391
Cdd:TIGR00396 312 GEKIPIWVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAeKDLSltaaYTEDGVLVNSGEFNGLNSSEAR 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 392 EQIIAYFEKENLGKRVINYRLQDWGVSRQRYWGAPIPMIHCNHCGIVP--ETQLPVTLPEDIVIDGEG-NPLEKHASWKF 468
Cdd:TIGR00396 392 NAIIDMLEKEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPvpEEDLPVILPEDVVYDGDGgSPLSRIPEWVN 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 469 TQCPKCHKNALRETDTMDTFIQSSWYFLRYTTPKNQreNQAFDQNYLKYFMPVDTYIGGIEHAILHLLYARFFTKALRDL 548
Cdd:TIGR00396 472 VTCPSCGKPALRETDTMDTFAGSSWYYLRYLDPKNT--DGPFDKEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRDI 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 549 GYLHLDEPFKQLITQGMVLKN--------------------------------GAKMSKSKGNVVSPKEILKKYGADAAR 596
Cdd:TIGR00396 550 GYVNTKEPFKKLINQGMVLGFyyppngkvpadvlterdekgkdkaggelvyvgYEKMSKSKGNGIDPQEIVESYGADALR 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 597 LFILFAAPPAKELEWNDSALEGAHRFIKRLYDKANAINPTTSKPEFKEVSLNEAQKLGRKKVYEALKKSHEIFNKAEsay 676
Cdd:TIGR00396 630 LFIMFMGPIAASLEWNESGLEGARRFLDRVWNLVYEITGELDAASLTVTALEEAQKELRRDVHKFLKKVTEDLEKRE--- 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 677 SFNTLIASCMEALNALSAQNNERILCEGYFVLLQILEPIIPHTAWELSERLFKRE----NFKPIAIDEDALMEDFMTLGL 752
Cdd:TIGR00396 707 SFNTAISAMMELLNKLYKAKKEALMLEYLKGFVTVLSPFAPHLAEELWEKLGSEPfiidNAKWPVVDETALVEDKTLIVV 786
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*.
gi 3024678 753 TINGKRRAELKVNINASKEEIIVLAKK--ELEKYLENASVKKEIYVPNKLVNFVIA 806
Cdd:TIGR00396 787 QVNGKFRAKITVPKDADEEQVEELAKQdpEVKKYLENKTIKKVIYVPGKLVNFVIK 842
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
2-806 |
0e+00 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 1249.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 2 DFINIEKKWQEFWWKNKSFEPKDDFNLPKKYILSMLPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMP 81
Cdd:COG0495 6 NPKEIEKKWQKYWEENGTFKADEDSSKPKYYVLDMFPYPSGRLHMGHVRNYTIGDVVARYKRMQGYNVLHPMGWDAFGLP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 82 AENAAIKHGIHPKTWTYENIENMQKEFEALGFSFSKNREFATSDPDYTKFEQRFFIDLWEKGLIYRKKAMLNWCPNDKTV 161
Cdd:COG0495 86 AENAAIKNGVHPAEWTYENIANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNWCPVDQTV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 162 LANEQVIDGRCWRCDTEVIQKELYQYYLKITNYAEELLKDLEALeDHWPSQVLIMQKNWIGKSSGLQFGFKIADeclkac 241
Cdd:COG0495 166 LANEQVIDGRCWRCGAPVEKKELPQWFLKITDYADELLDDLDKL-DGWPEKVKTMQRNWIGRSEGAEVDFPVEG------ 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 242 nGIQEIEVFTTRADTIYGVTYIAIAPEHPLVEHAIK-QVSQEVSKMIKAILNTTQRERAL---EKKGAFLGIYAIHPLTK 317
Cdd:COG0495 239 -SDEKITVFTTRPDTLFGATFMVLAPEHPLVKELATpEQNAAVAAFIEEAKKKSEIERTSetkEKTGVFTGLYAINPLTG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 318 QKIPVWVANFALANYGSGALMGVPACDERDFEFANLYHIPIK-VI------TQSPQNLPHTKEEVLKNSGEWSDLSSSVA 390
Cdd:COG0495 318 EKIPIWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKqVIapedgdDPDILEEAYTGDGVLINSGEFDGLDSEEA 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 391 REQIIAYFEKENLGKRVINYRLQDWGVSRQRYWGAPIPMIHCNHCGI--VPETQLPVTLPEDIVIDGEG-NPLEKHASWK 467
Cdd:COG0495 398 KEAIIEWLEEKGLGKRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVvpVPEDQLPVELPEDVDFDPTGgSPLARAPEWV 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 468 FTQCPKCHKNALRETDTMDTFIQSSWYFLRYTTPKNqrENQAFDQNYLKYFMPVDTYIGGIEHAILHLLYARFFTKALRD 547
Cdd:COG0495 478 NVTCPKCGGPARRETDTMDTFVDSSWYYLRYTDPHN--DEAPFDPEAANYWLPVDQYIGGIEHAILHLLYARFFTKVLRD 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 548 LGYLHLDEPFKQLITQGMVLKNG---------AKMSKSKGNVVSPKEILKKYGADAARLFILFAAPPAKELEWNDSALEG 618
Cdd:COG0495 556 LGLVSFDEPFKRLLTQGMVLEVGkdgvviggiEKMSKSKGNVVDPDEIIEKYGADTLRLFEMFAGPPERDLEWSDSGVEG 635
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 619 AHRFIKRLYdkaNAINPTTSKPEFKEVSLNEAQKLGRKKVYEALKK-SHEIfnkaeSAYSFNTLIASCMEALNALSAQ-- 695
Cdd:COG0495 636 AYRFLNRVW---RLVVDEAEALKLDVADLSEADKELRRALHKTIKKvTEDI-----ERLRFNTAIAALMELVNALYKAkd 707
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 696 ---NNERILCEGYFVLLQILEPIIPHTAWELSERLFKRENfkpIA------IDEDALMEDFMTLGLTINGKRRAELKVNI 766
Cdd:COG0495 708 sgeADRAVLREALETLVLLLAPFAPHIAEELWERLGHEGS---VAdapwpeADEAALVEDEVTIVVQVNGKVRGKIEVPA 784
|
810 820 830 840
....*....|....*....|....*....|....*....|..
gi 3024678 767 NASKEEIIVLAKKE--LEKYLENASVKKEIYVPNKLVNFVIA 806
Cdd:COG0495 785 DASKEELEAAALADekVQKFLEGKTIRKVIVVPGKLVNIVVK 826
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
3-804 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 730.85 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 3 FINIEKKWQEFWWKNKSFEPKDDFNL--PKKYILSMLPYPSGE-IHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFG 79
Cdd:PLN02563 82 FHEIEPKWQRYWEENRTFRTPDDVDTskPKFYVLDMFPYPSGAgLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFG 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 80 MPAENAAIKHGIHPKTWTYENIENMQKEFEALGFSFSKNREFATSDPDYTKFEQRFFIDLWEKGLIYRKKAMLNWCPNDK 159
Cdd:PLN02563 162 LPAEQYAIETGTHPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALG 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 160 TVLANEQVIDGRCWRCDTEVIQKELYQYYLKITNYAEELLKDLEALEdhWPSQVLIMQKNWIGKSSGLQFGFKIADECLK 239
Cdd:PLN02563 242 TVLANEEVVDGLSERGGHPVIRKPMRQWMLKITAYADRLLEDLDDLD--WPESIKEMQRNWIGRSEGAELDFSVLDGEGK 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 240 ACNgiQEIEVFTTRADTIYGVTYIAIAPEHPLVEHAikqVSQEVSKMIKAILNTTQR-------ERALEKKGAFLGIYAI 312
Cdd:PLN02563 320 ERD--EKITVYTTRPDTLFGATYLVVAPEHPLLSSL---TTAEQKEAVEEYVDAASRksdlertELQKEKTGVFTGSYAI 394
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 313 HPLTKQKIPVWVANFALANYGSGALMGVPACDERDFEFANLYHIPIKVITQSP------QNLPHTKEEVLKNSGEWS--- 383
Cdd:PLN02563 395 NPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPAdgneddAEKAYTGEGVIVNSSSSGldi 474
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 384 -DLSSSVAREQIIAYFEKENLGKRVINYRLQDWGVSRQRYWGAPIPMIHCNHCGI---VPETQLPVTLPE--DIVIDGEG 457
Cdd:PLN02563 475 nGLSSKEAAKKVIEWLEETGNGKKKVNYKLRDWLFARQRYWGEPIPVVFLEDSGEpvpVPESDLPLTLPEldDFTPTGTG 554
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 458 N-PLEKHASWKFTQCPKCHKNALRETDTMDTFIQSSWYFLRYTTPKNqrENQAFDQNYLKYFMPVDTYIGGIEHAILHLL 536
Cdd:PLN02563 555 EpPLAKAVSWVNTVDPSSGKPARRETNTMPQWAGSCWYYLRFMDPKN--SNALVDKEKEKYWMPVDLYVGGAEHAVLHLL 632
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 537 YARFFTKALRDLGYLHLDEPFKQLITQGMVL--------------------------------------KNGA------- 571
Cdd:PLN02563 633 YARFWHKVLYDIGVVSTKEPFQCLVNQGMILgeveytafkdsdgeyvsadtadrlgelqqekipeekviKSGDsfvlkdd 712
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 572 ----------KMSKSKGNVVSPKEILKKYGADAARLFILFAAPPAKELEWNDSALEGAHRFIKRLYDK-ANAINPTTSKP 640
Cdd:PLN02563 713 psirliarahKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWSTSGVEGVHRFLGRTWRLvVGAPLPDGSFR 792
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 641 EFKEVSLNEAQKLGRKKVYEALKK-SHEIfnkaESAySFNTLIASCMEALNALSAQNNERILCEGYFVLLqiLEPIIPHT 719
Cdd:PLN02563 793 DGTVVTDEEPSLEQLRLLHKCIAKvTEEI----EST-RFNTAISAMMEFTNAAYKWDKVPREAIEPFVLL--LSPYAPHL 865
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 720 AWELSERL-----FKRENFkPIAiDEDALMEDFMTLGLTINGKRRAELKVNINASKEEIIVLAKKE--LEKYLENASVKK 792
Cdd:PLN02563 866 AEELWFRLghsnsLAYEPW-PEA-NPSYLVDDTVVLPVQINGKTRGTIEVEEGCSEDDAFALASQDekLSKYLDGKEIKK 943
|
890
....*....|..
gi 3024678 793 EIYVPNKLVNFV 804
Cdd:PLN02563 944 RIYVPGKILNVI 955
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
30-611 |
1.61e-128 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 386.22 E-value: 1.61e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 30 KKYILSMLPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMPAENAAIKHGIHPKTWTYENIENMQKEFE 109
Cdd:cd00812 1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 110 ALGFSFSKNREFATSDPDYTKFEQRFFIDLWEKGLIYRKKAMLNWCpndktvlaneqvidgrcwrcdteviqKELYQYYL 189
Cdd:cd00812 81 RMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC--------------------------KLLDQWFL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 190 KI--TNYAEELLKDLEALeDHWPSqvlimqknwigkssglqfgfkiadeclkacngiqeievfttradtiygvtyiaiap 267
Cdd:cd00812 135 KYseTEWKEKLLKDLEKL-DGWPE-------------------------------------------------------- 157
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 268 ehplvehaikqvsqEVSKMIKAILnttqreralekkgaflgiyaihpltkqkipvwvanfalanygsgalmgvpacderd 347
Cdd:cd00812 158 --------------EVRAMQENWI-------------------------------------------------------- 167
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 348 fefanlyhipikvitqspqnlphtkeevlknsgewsdlsssvareqiiayfekenlgkrvinyrlqdwGVSRQRYWGAPI 427
Cdd:cd00812 168 --------------------------------------------------------------------GCSRQRYWGTPI 179
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 428 PMihcnhcgivpetqlpvtlpedividgegnplekhaswkftqcpkchknalreTDTMDTFIQSSWYFLRYTTPKNQREN 507
Cdd:cd00812 180 PW----------------------------------------------------TDTMESLSDSTWYYARYTDAHNLEQP 207
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 508 Q----AFDQNYLKYFMPVDTYIGGIEHAILHLLYARFFTKALRDLGYLHlDEPFKQLITQGMVLKNGAKMSKSKGNVVSP 583
Cdd:cd00812 208 YegdlEFDREEFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLVT-DEPPKGLIVQGMVLLEGEKMSKSKGNVVTP 286
|
570 580
....*....|....*....|....*...
gi 3024678 584 KEILKKYGADAARLFILFAAPPAKELEW 611
Cdd:cd00812 287 DEAIKKYGADAARLYILFAAPPDADFDW 314
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
2-786 |
5.70e-79 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 272.32 E-value: 5.70e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 2 DFINIEKKWQEFWWKNKSFEPKDDFNLPKKYILSMLPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMP 81
Cdd:TIGR00422 6 DPHEVEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAGIA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 82 AENAAIK-HGIHPKT---------------WTYENIENMQKEFEALGFSFSKNREFATSDPDYTKFEQRFFIDLWEKGLI 145
Cdd:TIGR00422 86 TQVKVEKkLGAEGKTkhdlgreefrekiweWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLYEKGLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 146 YRKKAMLNWCPNDKTVLANEQVidgrcwrcdtEVIQKELYQYYLKitnyaeellkdlealedhwpsqvlimqknwigkss 225
Cdd:TIGR00422 166 YRGEYLVNWDPKLNTAISDIEV----------EYKEVKGKLYYIR----------------------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 226 glqfgFKIADeclkacNGIQEIEVFTTRADTIYGVTYIAIAPEHPlvehaikqvsqevskmikailnttqRERALEKKga 305
Cdd:TIGR00422 201 -----YPLAN------GSKDYLVVATTRPETMFGDTAVAVHPEDE-------------------------RYKHLIGK-- 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 306 flgiYAIHPLTKQKIPVwVANFAL-ANYGSGALMGVPACDERDFEFANLYHIP-IKVITQspqnlphtKEEVLKNSGEWS 383
Cdd:TIGR00422 243 ----KVILPLTGRKIPI-IADEYVdMEFGTGAVKVTPAHDFNDYEWGKRHNLEfINILDE--------DGLLNENAGKYQ 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 384 DLSSSVAREQIIAYFEKENL----------------GKRVI-------------------------------------NY 410
Cdd:TIGR00422 310 GLTRFEARKKIVEDLKEEGLlvkiephthnvgtcwrSGTVVepllskqwfvkvekladkaleaaeegeikfvpkrmekRY 389
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 411 R-----LQDWGVSRQRYWGAPIPMIHCNHCGivpetQLPVTLPEDIVIDgegnPLEKHASWKFTQcpkchknalrETDTM 485
Cdd:TIGR00422 390 LnwlrnIKDWCISRQLIWGHRIPVWYCKECG-----EVYVAKEEPLPDD----KTNTGPSVELEQ----------DTDVL 450
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 486 DTFIQSS-WYFLRYTTPKNQREnqafdqnyLKYFMPVDTYIGGieHAILHLLYARFFTKALRDLGYLhldePFKQLITQG 564
Cdd:TIGR00422 451 DTWFSSSlWPFSTLGWPDETKD--------LKKFYPTDLLVTG--YDIIFFWVARMIFRSLALTGQV----PFKEVYIHG 516
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 565 MVL-KNGAKMSKSKGNVVSPKEILKKYGADAARLFILFAAPPAKELEWNDSALEGAHRFIKRLYDKAN-AINPTTSKPEF 642
Cdd:TIGR00422 517 LVRdEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFDWKRVESARNFLNKLWNASRfVLMNLSDDLEL 596
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 643 KEvsLNEAQKLGRKKVYEALKKSHEIFNKAESAYSFNTLIAS---------C---MEALNALSAQNNERILCEGYFVL-- 708
Cdd:TIGR00422 597 SG--GEEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKAlyefiwndfCdwyIELVKYRLYNGNEAEKKAARDTLyy 674
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 709 -----LQILEPIIPHTAWELSERLFKRE---------NFKPIAIDEDALmEDFMTLGLTINGKR--RAELKVNINASKEE 772
Cdd:TIGR00422 675 vldkaLRLLHPFMPFITEEIWQHFKEGAdsimlqsypVVDAEFVDEEAE-KAFELLKEIIVSIRnlKAESNIPPNAPLKV 753
|
890
....*....|....
gi 3024678 773 IIVLAKKELEKYLE 786
Cdd:TIGR00422 754 LLIYTEAETAERLK 767
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
218-399 |
6.46e-70 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 227.81 E-value: 6.46e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 218 KNWIGKSSGLQFGFKIADeclkacnGIQEIEVFTTRADTIYGVTYIAIAPEHPLVEHAIKQvSQEVSKMIKAILNTTQRE 297
Cdd:pfam13603 1 RNWIGRSEGAEITFPVEG-------TDEKIEVFTTRPDTLMGVTFVALAPEHPLVEKLAEK-NPEVAAFIEECKNTSEIE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 298 RAL---EKKGAFLGIYAIHPLTKQKIPVWVANFALANYGSGALMGVPACDERDFEFANLYHIPIKVITQSP--------Q 366
Cdd:pfam13603 73 RTSetkEKEGVFTGLYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQPEdgdldldiM 152
|
170 180 190
....*....|....*....|....*....|...
gi 3024678 367 NLPHTKEEVLKNSGEWSDLSSSVAREQIIAYFE 399
Cdd:pfam13603 153 TEAYTEEGILVNSGEFDGLDSEEAKEAIIKKLE 185
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
2-782 |
2.73e-61 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 221.61 E-value: 2.73e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 2 DFINIEKKWQEFWWKNKSFEPKDDfnlPKKYILSM---LPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSF 78
Cdd:PRK13208 11 DPEELEEKWQKIWEEEGTYKFDPD---ERKPVYSIdtpPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWDDN 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 79 GMP----AENaaiKHGIHP------------KTWTYENIENMQKEFEALGFSFSKNREFATSDPDYTKFEQRFFIDLWEK 142
Cdd:PRK13208 88 GLPterkVEK---YYGIRKddisreefielcRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLYKK 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 143 GLIYRKKAMLNWCPNDKTVLAneQVidgrcwrcDTEVIQKELYQYYLKitnyaeellkdlealedhwpsqvlimqknwig 222
Cdd:PRK13208 165 GLIYRAEAPVLWCPRCETAIA--QA--------EVEYREREGKLNYIK-------------------------------- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 223 kssglqfgFKIADEclkacngiQEIEVFTTRadtiygvtyiaiaPE----------HPLVEhaikqvsqevskmikailn 292
Cdd:PRK13208 203 --------FPVEDG--------EEIEIATTR-------------PEllpacvavvvHPDDE------------------- 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 293 ttqRERALekkgafLGIYAIHPLTKQKIPVwvanfaLA------NYGSGALMgvpAC---DERDFEFANLYHIPIK-VIT 362
Cdd:PRK13208 235 ---RYKHL------VGKTAIVPLFGVEVPI------LAdplvdpDFGTGAVM---ICtfgDKTDVTWWRELNLPTRiIID 296
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 363 QspqnlphtKEEVLKNSGEWSDLSSSVAREQIIAYFEKEN-LGK------RV---------------------------- 407
Cdd:PRK13208 297 E--------DGRMTEAAGKLAGLTIEEARKKIVEDLKSGGlLGKqepikhNVkfcercdtpleilvtrqwfikvldlkee 368
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 408 -------IN-------YRLQ--------DWGVSRQRYWGAPIPMIHCNHCG--IVPEtqlpvtlPEDIVIDgegnPLEKH 463
Cdd:PRK13208 369 llergkeINwypehmrVRLEnwieglnwDWCISRQRYFGTPIPVWYCKDCGhpILPD-------EEDLPVD----PTKDE 437
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 464 ASWKftQCPKCHKNALR-ETDTMDTFIQSSwyflryTTPknqrenqafdqnylkyfmpvdTYIGGIEhaILHLLYARFFT 542
Cdd:PRK13208 438 PPGY--KCPQCGSPGFEgETDVMDTWATSS------ITP---------------------LIVTGWE--RDEDLFEKVFP 486
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 543 KALRDLG---------------YLHLDE-PFKQLITQGMVL-KNGAKMSKSKGNVVSPKEILKKYGADAARLFILFAAP- 604
Cdd:PRK13208 487 MDLRPQGhdiirtwlfytilraYLLTGKlPWKNIMISGMVLdPDGKKMSKSKGNVVTPEELLEKYGADAVRYWAASARLg 566
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 605 ---PAKELE-----------WNdsalegAHRFIKRLYDKANAINPTTSKPefkevsLNEA--QKLGR--KKVYEALkKSH 666
Cdd:PRK13208 567 sdtPFDEKQvkigrrlltklWN------ASRFVLHFSADPEPDKAEVLEP------LDRWilAKLAKvvEKATEAL-ENY 633
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 667 EIFNKAESAYSF--NTLiasC--------------MEALNALSAQNNeriLCEGYFVLLQILEPIIPHTAWELSERLFKR 730
Cdd:PRK13208 634 DFAKALEEIESFfwHVF---CddylelvksraygeDEEEEQKSARYT---LYTVLDTLLRLLAPFLPFITEEVWSWLYGG 707
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3024678 731 -------ENFKPIAIDEDALmEDFMTLGLTINGKRRA--ELKVNINASKEEIIVLAKKELE 782
Cdd:PRK13208 708 svhraswPEPDEELIDEEDE-ELGELAKEILSAVRKYksEAGLSLNAPLKKVEVYGPADLE 767
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
9-611 |
8.35e-56 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 202.26 E-value: 8.35e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 9 KWQEFWWKNKSFEPKDDFNLPKKYILSML--PYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMPAENA- 85
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGKPSFTIHDgpPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVv 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 86 ----AIKHG----------IHPKTWTY--ENIENMQKEFEALGFSFSKNREFATSDPDYTKFEQRFFIDLWEKGLIYRKK 149
Cdd:pfam00133 81 ekklGIKEKktrhkygreeFREKCREWkmEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 150 AMLNWCPNDKTVLANeqvidgrcwrcdTEVIQKELyqyylkitnyaeellkdlealedhwpsqvlimqknwigKSSGLQF 229
Cdd:pfam00133 161 KLVNWSPALNTALSN------------LEVEYKDV--------------------------------------KGPSIHV 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 230 GFKIAD-ECLKacngiqeIEVFTTRADTIYGVTYIAIAPEHPLVEHAIKQVSQE--VSKMIKAILNTTQREralEKKGAF 306
Cdd:pfam00133 191 AFPLADdEGAS-------LVIWTTTPWTLPGNTAVAVNPEFDYVITGEGYILAEalLKSLYKKGTDKKILE---DFRGKE 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 307 L-GIYAIHPLTKQKIPVWVANFALANYGSGALMGVPACDERDFEFANLYHIP-IKVITQSPQnlphtkeeVLKNSGEWSD 384
Cdd:pfam00133 261 LeGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEvINPVDDDGT--------FTEEAPDFQG 332
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 385 LSSSVAREQIIAYFEKENL----------------GKRVINYRL------------------------------------ 412
Cdd:pfam00133 333 VYRFDARKKIVELLTEKGLllkiepfthsypfcwrSGTPIIPRAtpqwfvrmdeladqaleavekvqfvpksgekryfnw 412
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 413 ----QDWGVSRQRYWGAPIPMIHCNHCGIVPETQLPVTLPEDIVI-DGEGNPLEKHASWKFtqcpKCHKNAL-RETDTMD 486
Cdd:pfam00133 413 laniQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVAGRFEeEGSIKWLHREAKDKL----GYGKGTLeQDEDVLD 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 487 TFIQS-SWYFLRYTTPKNQRENqafdqnyLKYFMPVDTYIGGIEhaILHLLYAR--FFTKALRDlgylhlDEPFKQLITQ 563
Cdd:pfam00133 489 TWFSSgSWPFSTLGWPFVNTEE-------FKKFFPADMLLEGSD--QTRGWFYRmiMLSTALTG------SVPFKNVLVH 553
|
650 660 670 680
....*....|....*....|....*....|....*....|....*....
gi 3024678 564 GMVL-KNGAKMSKSKGNVVSPKEILKKYGADAARLFILFaAPPAKELEW 611
Cdd:pfam00133 554 GLVRdEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLAN-SDYGRDINL 601
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
38-605 |
6.17e-53 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 188.61 E-value: 6.17e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 38 PYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMPAENAAIKH-GIHPKT---------------WTYENI 101
Cdd:cd00817 10 PNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKlGIEGKTrhdlgreeflekcweWKEESG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 102 ENMQKEFEALGFSFSKNREFATSDPDYTKFEQRFFIDLWEKGLIYRKKAMLNWCPNDKTVLANEQVidgrCWRCDT--EV 179
Cdd:cd00817 90 GKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV----CSRSGDviEP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 180 IQKElyQYYLKITNYAEELLKDLEALEdhwpsqvlimqknwigkssglqfgfkiadeclkacngiqeievfttradtiyg 259
Cdd:cd00817 166 LLKP--QWFVKVKDLAKKALEAVKEGD----------------------------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 260 vtyIAIAPEHplvehaikqvsqevskMIKAILNttqreralekkgaflgiyaihpltkqkipvWVANfalanygsgalmg 339
Cdd:cd00817 191 ---IKFVPER----------------MEKRYEN------------------------------WLEN------------- 208
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 340 vpacderdfefanlyhipikvitqspqnlphtkeevlknsgewsdlsssvareqiiayfekenlgkrvinyrLQDWGVSR 419
Cdd:cd00817 209 ------------------------------------------------------------------------IRDWCISR 216
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 420 QRYWGAPIPMIHCNHCGivpetQLPVTLPEDIVIDgegnplekhaSWKFTQCPKCHKNAL-RETDTMDTFIQSS-WYFLR 497
Cdd:cd00817 217 QLWWGHRIPAWYCKDGG-----HWVVAREEDEAID----------KAAPEACVPCGGEELkQDEDVLDTWFSSSlWPFST 281
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 498 YTTPKnqrenqafDQNYLKYFMPVDTYIGGieHAILhllyarfFTKALRD--LGYLHLDE-PFKQLITQGMVL-KNGAKM 573
Cdd:cd00817 282 LGWPE--------ETKDLKKFYPTSLLVTG--HDII-------FFWVARMimRGLKLTGKlPFKEVYLHGLVRdEDGRKM 344
|
570 580 590
....*....|....*....|....*....|..
gi 3024678 574 SKSKGNVVSPKEILKKYGADAARLFILFAAPP 605
Cdd:cd00817 345 SKSLGNVIDPLDVIDGYGADALRFTLASAATQ 376
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
2-787 |
4.30e-46 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 177.60 E-value: 4.30e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 2 DFINIEKKWQEFWWKNKSFEPKDdfNLPKKY-IlsMLPYP--SGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSF 78
Cdd:PRK05729 10 DPKEVEAKWYQKWEEKGYFKPDD--NSKKPFsI--VIPPPnvTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLPGTDHA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 79 G----MPAENAAIKHGIHP----------KTW----TYENI--ENMQKefeaLGFSFSKNREFATSDPDYTKFEQRFFID 138
Cdd:PRK05729 86 GiatqMVVERQLAAEGKSRhdlgrekfleKVWewkeESGGTitNQLRR----LGASCDWSRERFTMDEGLSKAVREVFVR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 139 LWEKGLIYRKKAMLNWCPNDKTVLANEqvidgrcwrcdtEVIQKELYQ--YYLKitnYaeellkdlealedhwpsqvlim 216
Cdd:PRK05729 162 LYEKGLIYRGKRLVNWDPKLQTALSDL------------EVEYKEVKGklWHIR---Y---------------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 217 qknwigkssglqfgfKIADeclkacnGIQEIEVFTTRADTIYGVTYIAIAPEHPlvehaikqvsqevskmikailnttqR 296
Cdd:PRK05729 205 ---------------PLAD-------GSDYLVVATTRPETMLGDTAVAVNPEDE-------------------------R 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 297 ERALEKKgaflgiYAIHPLTKQKIPVwVA-NFALANYGSGALMGVPACDERDFEFANLYHIP-IKVITQspqnlphtKEE 374
Cdd:PRK05729 238 YKHLIGK------TVILPLVGREIPI-IAdEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPmINIMDE--------DGT 302
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 375 VLKNSGEWSDLSSSVAREQIIAYFEKENL----------------GKRVI------------------------------ 408
Cdd:PRK05729 303 INENPGEYQGLDRFEARKAIVADLEELGLlvkiephthsvghsdrSGVVIepylsdqwfvkmkplakpaleavengeikf 382
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 409 -------NYR-----LQDWGVSRQRYWGAPIPMIHCNHCGI-VPETQlpvtlPEDividgegnplekhaswkftqcpkCH 475
Cdd:PRK05729 383 vperwekTYFhwmenIQDWCISRQLWWGHRIPAWYDEDGEVyVGREE-----PEA-----------------------RE 434
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 476 KNAL-RETDTMDT-FiqSS--WYFlryTT---PKNQREnqafdqnyLKYFMPVDTYIGGieHAILHLLYAR--FFTKALR 546
Cdd:PRK05729 435 KALLtQDEDVLDTwF--SSalWPF---STlgwPEKTED--------LKRFYPTSVLVTG--FDIIFFWVARmiMMGLHFT 499
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 547 DlgylhlDEPFKQ-LITqGMVL-KNGAKMSKSKGNVVSPKEILKKYGADAARLFILFAAPPAKELEWNDSALEGAHRFIK 624
Cdd:PRK05729 500 G------QVPFKDvYIH-GLVRdEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIRFDEERVEGYRNFAN 572
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 625 RLYdkaNA-----INPTTSKPEF--KEVSLNEAQK--LGR-----KKVYEALKKSHeiFNKA-ESAYSF--NTLiasC-- 685
Cdd:PRK05729 573 KLW---NAsrfvlMNLEGADVGElpDPEELSLADRwiLSRlnrtvAEVTEALDKYR--FDEAaRALYEFiwNEF---Cdw 644
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 686 -MEA----LNALSAQNNERILcegYFVL---LQILEPIIPHTAWELSERLFKRENFKPIAI----------DEDAL--ME 745
Cdd:PRK05729 645 yLELakpvLQEAAKRATRATL---AYVLeqiLRLLHPFMPFITEELWQKLAPLGIEESIMLapwpeadeaiDEAAEaeFE 721
|
890 900 910 920
....*....|....*....|....*....|....*....|....
gi 3024678 746 DFMTLgltINGKRRAELKVNINASKEE--IIVLAKKELEKYLEN 787
Cdd:PRK05729 722 WLKEL---ITAIRNIRAEMNIPPSKKLplLLKGADAEDRARLEA 762
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
44-794 |
5.91e-46 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 177.37 E-value: 5.91e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 44 IHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMP----AEnaAIKHGiHPKT-WTYENI----------------- 101
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPilgiAE--RIARG-DPETiELYKSLygipeeelekfkdpeyi 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 102 -----ENMQKEFEALGFSFSKNREFATSDPDYTKFEQRFFIDLWEKGLIYRKKAMLNWCPNDKTVLANEQVIDGrcwrcd 176
Cdd:PRK12300 78 veyfsEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDG------ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 177 tevIQKELYQYylkitnyaeellkdlealedhwpsqVLIMqknwigkssglqfgFKIADECLKACngiqeievFTTRADT 256
Cdd:PRK12300 152 ---EEPEIVEY-------------------------TLIK--------------FEESEDLILPA--------ATLRPET 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 257 IYGVTYIAIAPEhplVEHAIKQVSQE---VSKmiKAILNTTQRERALE-----KKGAFLGIYAIHPLTKQKIPVWVANFA 328
Cdd:PRK12300 182 IFGVTNLWVNPD---ATYVKAEVDGEkwiVSK--EAAEKLSFQDRDVEiieeiKGSELIGKKVKNPVTGKEVPILPADFV 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 329 LANYGSGALMGVPACDERDF--------EFANLYHI-PIKVIT--------------------QSPQNLPHTKEEVLK-- 377
Cdd:PRK12300 257 DPDNGTGVVMSVPAHAPYDYvalrdlkkNKELLDVIePIPLIEvegygefpakevveklgiksQEDPELEEATKEVYRae 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 378 --------NSGEWSDLSSSVAREQIIAYFEKENLG--------KRVI--------------------------------- 408
Cdd:PRK12300 337 fhkgvlkeNTGEYAGKPVREAREKITKDLIEKGIAdimyefsnRPVYcrcgtecvvkvvkdqwfidysdpewkelahkal 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 409 --------NYR---------LQDWGVSRQRYWGAPIP-----MI-----------------HCNHCGIVPEtQLPvtlPE 449
Cdd:PRK12300 417 dnmeiipeEYRkefentidwLKDRACARRRGLGTRLPwdeewIIeslsdstiymayytiahKIREYGIKPE-QLT---PE 492
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 450 --DIVIDGEGNPlekhaswkftqcpkchknalrETDTMDTFIqsswyflryttPKNQRENQafdQNYLKYFMPVDTYIGG 527
Cdd:PRK12300 493 ffDYVFLGKGDP---------------------EEVSKKTGI-----------PKEILEEM---REEFLYWYPVDWRHSG 537
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 528 IEHAILHLLYARFFTKALRDLGYLhldePfKQLITQGMVLKNGAKMSKSKGNVVSPKEILKKYGADAARLFILFAAPPAK 607
Cdd:PRK12300 538 KDLIPNHLTFFIFNHVAIFPEEKW----P-RGIVVNGFVLLEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQ 612
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 608 ELEWNDSALEGAHRFIKRLYDKANAINPTTSKPEfkevsLNEAQKLGRKKVYEALKKSHEIFNKAESAYSFNTLIASCME 687
Cdd:PRK12300 613 DADWREKEVESVRRQLERFYELAKELIEIGGEEE-----LRFIDKWLLSRLNRIIKETTEAMESFQTRDAVQEAFYELLN 687
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 688 ALN---ALSAQNNERILCEGYFVLLQILEPIIPHTAWELSERLfKRENF---------KPIAIDEDA-LMEDFmtLGLTI 754
Cdd:PRK12300 688 DLRwylRRVGEANNKVLREVLEIWIRLLAPFTPHLAEELWHKL-GGEGFvslekwpepDESKIDEEAeLAEEY--VKRLI 764
|
890 900 910 920
....*....|....*....|....*....|....*....|...
gi 3024678 755 NGKRRAELKVNINASKEEIIVLAK---KELEKYLENASVKKEI 794
Cdd:PRK12300 765 EDIREILKVAKIKPKKVYIYVAPDwkyEVLEIAAENGDVKEAI 807
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
2-800 |
4.06e-44 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 171.79 E-value: 4.06e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 2 DFINIEKKWQEFWWKNKSFE-----PKDDfnlPKKYILSMLPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFD 76
Cdd:TIGR00392 7 NLSKREEKILAFWQENDIFEkvkklNKGK---PEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPGWD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 77 SFGMPAENAAIKH-GIHPK----------------TWTYENIENMQKEFEALGFSFSKNREFATSDPDYTKFEQRFFIDL 139
Cdd:TIGR00392 84 THGLPIEHKVEKKlGISGKkeissleieefrekcrEFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFKEA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 140 WEKGLIYRKKAMLNWCPNDKTVLANeqvidgrcwrcdTEVIQKELYqyylkitnyaeellkdlealedhwpsqvlimqkn 219
Cdd:TIGR00392 164 HEKGLLYRGLKPVYWSPRCRTALAE------------AEVEYKENY---------------------------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 220 WIGKSSGLQFGFKIA-DECLKACNGIQEIEVFTTRADTIYGVTYIAIAP--EHPLVEHAIKQVSQEV-SKMIKAILNTTQ 295
Cdd:TIGR00392 198 KDVKDPSIYVKFPVKkDKKTYLKVKLSSLLIWTTTPWTLPSNLAIAVHPdfEYALVQDNTKVEYFILaKKLVEKLYNKAG 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 296 REraLEKKGAFLG-----IYAIHPL------TKQKIPVWV-ANFALANYGSGALMGVPACDERDFEFANLYHIPI----- 358
Cdd:TIGR00392 278 SD--YEIIKTFKGsdlegLEYEHPLydfvsqLKEGAPVVIgGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVlspvd 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 359 ----------------------------KVITQSPQNL-------------PH---TKEEVLKNSGEWSDLSSSVAREQI 394
Cdd:TIGR00392 356 ekgvytegvndfqgrfvkdadkdiikanKIIIEQLKDKglllkaekithsyPHcwrTKTPVIYRATEQWFIKTKDIKDQM 435
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 395 IAYFEK-----ENLGKRVINY--RLQDWGVSRQRYWGAPIPMIHCNHCGIVPETQLPVTLPEDIVIDGEGNPLEK----H 463
Cdd:TIGR00392 436 LEQIKKvnwvpEWGEGRFGNWleNRPDWCISRQRYWGIPIPIWYCEDTGEPIVVGSIEELIELIELKGIDAWFEDlhrdF 515
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 464 ASWKFTQCPKCHKnALRETDTMDTFIQS--SWYFLRYttpkNQRENQAFDQNYlkyfmPVDTYIGGIEHailhllyAR-- 539
Cdd:TIGR00392 516 LDKITLKSGDGGE-YRRVPDVLDVWFDSgsMPYASIH----YPFENEKFKEVF-----PADFILEGSDQ-------TRgw 578
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 540 FFTKALrdLGYLHLDE-PFKQLITQGMVL-KNGAKMSKSKGNVVSPKEILKKYGADAARLFILFAApPAKELEWNDSALE 617
Cdd:TIGR00392 579 FYSSLA--IGTALFGQaPYKNVITHGFTLdEKGRKMSKSLGNVVDPLKVINKYGADILRLYVASSD-PWEDLRFSDEILK 655
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 618 GAHRFIKRLYDKA-----NAINPTTSKPEFKEVSLNEAQKLGRKKVYEaLKKSHEIFNKAESAYSF----NTLIASCMEA 688
Cdd:TIGR00392 656 QVVEKYRKIRWNTyrfllTYANLDKFDPLFNSVAVEKFPEEDRWILSR-LNSLVEEVNEALEKYNFhkvlRALQDFIVEE 734
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 689 LN-------------------ALSAQNnerILCEGYFVLLQILEPIIPHTAWELSERLFKRENFKPIAIDEDA-LMEDFM 748
Cdd:TIGR00392 735 LSnwyiriirdrlyceakdndKRAAQT---TLYYALLTLVRLLAPFLPHTAEEIYQNLPGGEEEESVHLNLWPeVDEEFI 811
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|..
gi 3024678 749 TLGLtingkrraELKVNINASKEEIIVLAKKELEKYLENAsvKKEIYVPNKL 800
Cdd:TIGR00392 812 DEAL--------EANMAIVREIVEAFLALRDAANKKLRQP--LKELVIGKSL 853
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
2-783 |
4.89e-38 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 152.90 E-value: 4.89e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 2 DFINIEKKWQEFWWKNKSFEPKDDFNLPKKYIlsMLPYP--SGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFG 79
Cdd:COG0525 8 DPKEVEAKWYQYWEENGYFKADPDSDKEPFTI--VIPPPnvTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPGTDHAG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 80 ----MPAENAAIKHGIHP----------KTW----TYENI--ENMQKefeaLGFSFSKNRE-FaTSDPDYTKFEQRFFID 138
Cdd:COG0525 86 iatqAVVERQLAEEGKSRhdlgrekfleRVWewkeESGGTitNQLRR----LGASCDWSRErF-TMDEGLSKAVREVFVR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 139 LWEKGLIYRKKAMLNWCPNDKTVLANEqvidgrcwrcdtEVIQKE----LYqyYLKitnYaeellkdlealedhwpsqvl 214
Cdd:COG0525 161 LYEKGLIYRGKRLVNWDPKLKTALSDL------------EVEHEEvkghLW--HIR---Y-------------------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 215 imqknwigkssglqfgfKIADeclkacnGIQEIEVFTTRADTIYGVTYIAIAPEHPlvehaikqvsqevskmikailntt 294
Cdd:COG0525 204 -----------------PLAD-------GSGYIVVATTRPETMLGDTAVAVHPEDE------------------------ 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 295 qRERALekkgafLGIYAIHPLTKQKIPVwVA------NFalanyGSGALMGVPACDERDFEFANLYHIP-IKVITqspqn 367
Cdd:COG0525 236 -RYKHL------IGKTVILPLVGREIPI-IAdeyvdpEF-----GTGAVKITPAHDPNDFEVGKRHNLPmINILD----- 297
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 368 lphtkEE--VLKNSGEWSDLSSSVAREQIIAYFEKENL----------------GKRVI--------------------- 408
Cdd:COG0525 298 -----EDgtINENAGKYRGLDRFEARKAIVADLEELGLlvkvephkhsvghsdrSGTVIepylsdqwfvkmkplakpaie 372
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 409 ----------------NYR-----LQDWGVSRQRYWGAPIPMIHCnhcgivPETQLPVTLPEDividgegnplekhaswk 467
Cdd:COG0525 373 avedgeikfvperwekTYFhwmenIRDWCISRQLWWGHRIPAWYC------PDGEVYVARTEP----------------- 429
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 468 fTQCPKCHKNAL-RETDTMDT-FiqSS--WYFlryTT---PKNQREnqafdqnyLKYFMPVDTYIGGieHAILHLLYAR- 539
Cdd:COG0525 430 -EACAKAGSVNLtQDEDVLDTwF--SSalWPF---STlgwPEKTED--------LKYFYPTSVLVTG--FDIIFFWVARm 493
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 540 -----FFTKalrdlgylhlDEPFKQ-LITqGMVL-KNGAKMSKSKGNVVSPKEILKKYGADAARLFILFAAPPAKELEWN 612
Cdd:COG0525 494 immglHFTG----------EVPFKDvYIH-GLVRdEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIKFD 562
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 613 DSALEGAHRFIKRLYdkaNA-----INPTTSKPEFKEVS----------LNEAQKLgRKKVYEALKKSHeiFNKA-ESAY 676
Cdd:COG0525 563 EERVEGYRNFANKLW---NAsrfvlMNLEGFDPGLDPDPeelsladrwiLSRLNKT-IAEVTEALEKYR--FDEAaQALY 636
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 677 SF--NT-------LIASCMEALNALSAQNNERILCEGYFVLLQILEPIIPHTAWELSERLFKRENFKPIA---------- 737
Cdd:COG0525 637 DFvwNEfcdwyleLAKPRLYGGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPPRKEGESIMlapwpeadee 716
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|..
gi 3024678 738 -IDEDAL--MEDFMTLgltINGKR--RAELkvNINASKE-EIIVLAKKELEK 783
Cdd:COG0525 717 lIDEEAEaeFEWLKEV---ISAIRniRAEM--NIPPSKKlPLLLKGADEADR 763
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
2-774 |
1.37e-37 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 151.77 E-value: 1.37e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 2 DFINIEKKWQEFWWKN----KSFEPKDDfnlPKKYILsmL---PYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMG 74
Cdd:COG0060 17 NLPKREPEILKFWEENdiyeKSREARAG---RPKFVL--HdgpPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 75 FDSFGMPAENAAIK-HGIHPKTWT---------------YENIENMQKEFEALGFSFSKNREFATSDPDYTKFEQRFFID 138
Cdd:COG0060 92 WDCHGLPIELKVEKeLGIKKKDIEkvgiaefrekcreyaLKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEESIWWALKK 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 139 LWEKGLIYRKKAMLNWCPNDKTVLANeqvidgrcwrcdTEViqkelyqyylkitNYAEEllKDlealedhwPSqvlImqk 218
Cdd:COG0060 172 LYEKGLLYKGLKPVPWCPRCGTALAE------------AEV-------------EYKDV--TS--------PS---I--- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 219 nWIGkssglqfgFKIADECLKACNGIQEIEVFTT--------RA-----DTIYGV-------TYIaIApeHPLVEHAIKQ 278
Cdd:COG0060 211 -YVK--------FPVKDEKALLLLEDAYLVIWTTtpwtlpanLAvavhpDIDYVLvevtggeRLI-LA--EALVEAVLKE 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 279 VSQEVSKMIKailnttqreralEKKGAFL-GIYAIHPL-----TKQKIPVWVANFALANYGSGAlmgV---PACDERDFE 349
Cdd:COG0060 279 LGIEDYEVLA------------TFKGAELeGLRYEHPFyyvvgYDRAHPVILGDYVTTEDGTGI---VhtaPGHGEDDFE 343
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 350 FANLYHIPI--------------------------KVITQspqNL----------------PH---TKEEVL-KNSGEW- 382
Cdd:COG0060 344 VGKKYGLPVlnpvdddgrfteeaplfaglfvkdanPAIIE---DLkergallarekithsyPHcwrCKTPLIyRATPQWf 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 383 ---SDLsssvaREQIIA-------YFE-KEN-LGKRVINyrLQDWGVSRQRYWGAPIPMIHCNHCGivpETQLPVTLPED 450
Cdd:COG0060 421 ismDKL-----RDRALEaiekvnwIPEwGEGrFGNMLEN--RPDWCISRQRYWGVPIPIWVCEDCG---ELHRTEEVIGS 490
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 451 IVidgegNPLEKH---ASWKFT----------QCPKCHKNALRETDTMDTFIQS--SWYF-LRyttpknQRENQAFdqny 514
Cdd:COG0060 491 VA-----ELLEEEgadAWFELDlhrpfldetlKCPKCGGTMRRVPDVLDVWFDSgsMHFAvLE------NREELHF---- 555
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 515 lkyfmPVDTYIGGI-EHailhllyaR--FFTkalrdlgyLHL------DE-PFKQLITQGMVL-KNGAKMSKSKGNVVSP 583
Cdd:COG0060 556 -----PADFYLEGSdQT--------RgwFYS--------SLLtstalfGRaPYKNVLTHGFVLdEDGRKMSKSLGNVVDP 614
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 584 KEILKKYGADAARLFILfAAPPAKELEWNDSALEGAHRFIKRLYD-----KANA--INPTTSKPEFKEVS------LNEA 650
Cdd:COG0060 615 QEVIDKYGADILRLWVA-SSDYWGDLRFSDEILKEVRDVYRRLRNtyrflLANLddFDPAEDAVPYEDLPeldrwiLSRL 693
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 651 QKLgRKKVYEALkksheifnkaeSAYSFNTLIASCME-ALNALSA----QNNERILCEG---------YFVLLQILE--- 713
Cdd:COG0060 694 NEL-IKEVTEAY-----------DNYDFHRAYRALHNfCVEDLSNwyldISKDRLYTEAadsldrraaQTTLYEVLEtlv 761
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3024678 714 ----PIIPHTAWELSERLFKRE----------NFKPIAIDEDalMEDFMTLGLTIngkRRAELKVNINASKEEII 774
Cdd:COG0060 762 rllaPILPFTAEEIWQNLPGEAeesvhladwpEVDEELIDEE--LEAKWDLVREV---RSAVLKALEAARKEKLI 831
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
6-628 |
4.80e-37 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 150.14 E-value: 4.80e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 6 IEKKWQEFWWKNKSFEPKD-DFNLPKKYILSMLPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMPAE- 83
Cdd:PRK14900 24 VEARWYPFWQERGYFHGDEhDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIATQm 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 84 ------NAAIKHGIH--------PKTWTYENI--ENMQKEFEALGFSFSKNREFATSDPDYTKFEQRFFIDLWEKGLIYR 147
Cdd:PRK14900 104 ivekelKKTEKKSRHdlgreaflERVWAWKEQygSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHEEGLIYR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 148 KKAMLNWCPNDKTVLAneqvidgrcwrcDTEVIQKELYQYYLkitnyaeellkdlealedhwpsqvlimqknWigkssgl 227
Cdd:PRK14900 184 EKKLINWCPDCRTALS------------DLEVEHEEAHQGEL------------------------------W------- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 228 QFGFKIADeclkacnGIQEIEVFTTRADTIYGVTYIAIAPEHPlvehaikqvsqevskmikailnttqRERALekkgafL 307
Cdd:PRK14900 215 SFAYPLAD-------GSGEIVVATTRPETMLGDTAVAVHPLDP-------------------------RYMAL------H 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 308 GIYAIHPLTKQKIPVwVANFALAN--YGSGALMGVPACDERDFEFANLYHIP-IKVITQS-------------------P 365
Cdd:PRK14900 257 GKKVRHPITGRTFPI-VADAILVDpkFGTGAVKVTPAHDFNDFEVGKRHGLEmITVIGPDgrmtaeagplagldrfearK 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 366 QNLPHTKEEVLKNSGEWSDLS------SSVAREQIIA---YFEKENLGKRVIN----------------------YRLQD 414
Cdd:PRK14900 336 EVKRLLAEQGLDRGAKPHVLPlgrcqrSATILEPLLSdqwYVRIEPLARPAIEaveqgrtrfipeqwtntymawmRNIHD 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 415 WGVSRQRYWGAPIPMIHCnhcgivpetqlpvtlPEDIVIDGEGNPlekhaswkfTQCPKCHKNALRE-TDTMDTFIQSS- 492
Cdd:PRK14900 416 WCISRQLWWGHQIPAWYC---------------PDGHVTVARETP---------EACSTCGKAELRQdEDVLDTWFSSGl 471
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 493 WYFLRYTTPKNQREnqafdqnyLKYFMPVDTYIGGieHAILHLLYARFFTKALRDLGylhlDEPFKQLITQGMVL-KNGA 571
Cdd:PRK14900 472 WPFSTMGWPEQTDT--------LRTFYPTSVMETG--HDIIFFWVARMMMMGLHFMG----EVPFRTVYLHPMVRdEKGQ 537
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*..
gi 3024678 572 KMSKSKGNVVSPKEILKKYGADAARLFILFAAPPAKELEWNDSALEGAHRFIKRLYD 628
Cdd:PRK14900 538 KMSKTKGNVIDPLVITEQYGADALRFTLAALTAQGRDIKLAKERIEGYRAFANKLWN 594
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
31-611 |
5.28e-30 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 120.99 E-value: 5.28e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 31 KYILSM-LPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMPAENAAIKHGIH-------------PKTW 96
Cdd:cd00668 1 KFYVTTpPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRkkktiwieefredPKEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 97 TYENIENMQKEFEALGFSFSKNREFATSDPDYTKFEQRFFIDLWEKGLIYRKKamlnwcpndKTVLANEqvidgrcwrcd 176
Cdd:cd00668 81 VEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGT---------HPVRITE----------- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 177 teviqkelyQYYLKITNYAEELLKdlealedhwpsqvlimqknwigkssglqfgfkiadeclkacnGIQEievfttradt 256
Cdd:cd00668 141 ---------QWFFDMPKFKEKLLK------------------------------------------ALRR---------- 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 257 iygvtyIAIAPEHplvehaikqvsqevskmikailnttqreralekkgaflgiyaihplTKQKIPVWVANfalanygsga 336
Cdd:cd00668 160 ------GKIVPEH----------------------------------------------VKNRMEAWLES---------- 177
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 337 lmgvpacderdfefanlyhipikvitqspqnlphtkeevlknsgewsdlsssvareqiiayfekenlgkrvinyrLQDWG 416
Cdd:cd00668 178 ---------------------------------------------------------------------------LLDWA 182
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 417 VSRQRYWGAPIPmihcnhcgivpetqlpvtlpedividgegnplekhaswkftqcpkchknalreTDTMDTFIQSS-WYF 495
Cdd:cd00668 183 ISRQRYWGTPLP-----------------------------------------------------EDVFDVWFDSGiGPL 209
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 496 LRYTTPknqrenqaFDQNYLKYFMPVDTYIGGIEHAILHLLYARFFTKALRdlgylhLDEPFKQLITQGMVLKN-GAKMS 574
Cdd:cd00668 210 GSLGYP--------EEKEWFKDSYPADWHLIGKDILRGWANFWITMLVALF------GEIPPKNLLVHGFVLDEgGQKMS 275
|
570 580 590
....*....|....*....|....*....|....*..
gi 3024678 575 KSKGNVVSPKEILKKYGADAARLFILFAAPPAKELEW 611
Cdd:cd00668 276 KSKGNVIDPSDVVEKYGADALRYYLTSLAPYGDDIRL 312
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
30-228 |
1.34e-29 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 119.94 E-value: 1.34e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 30 KKYILSMLPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMPAENAAIKHGIHPKTWTYENIENMQKEFE 109
Cdd:cd00814 1 KVLITTALPYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELCDKYHEIFKDLFK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 110 ALGFSFSKnreFA-TSDPDYTKFEQRFFIDLWEKGLIYrKKAMLNW-CPNDKTVLAneqvidgrcwrcdtEVIQKElyQY 187
Cdd:cd00814 81 WLNISFDY---FIrTTSPRHKEIVQEFFKKLYENGYIY-EGEYEGLyCVSCERFLP--------------EWREEE--HY 140
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 3024678 188 YLKITNYAEELLKDLEALED-HWPSQVLIMQKNWIgkSSGLQ 228
Cdd:cd00814 141 FFRLSKFQDRLLEWLEKNPDfIWPENARNEVLSWL--KEGLK 180
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
6-588 |
1.79e-28 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 122.81 E-value: 1.79e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 6 IEKKWQEFWWKNKSFEPKDDFNLP---KKYILsMLPYP--SGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGM 80
Cdd:PTZ00419 33 VESGWYEWWEKSGFFKPAEDAKSLnsgKKFVI-VLPPPnvTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 81 PA----------ENAAIKHGIHPKT-------WTYENIENMQKEFEALGFSFSKNREFATSDPDYTKFEQRFFIDLWEKG 143
Cdd:PTZ00419 112 ATqvvvekklmkEENKTRHDLGREEflkkvweWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKEAFVRLYEDG 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 144 LIYRKKAMLNWCPNDKTVLANEQVidgrcwrcDTEVIQKELyqyYLKITNYaeELLKDLEALedhwpsqvlimqknWIgk 223
Cdd:PTZ00419 192 LIYRDTRLVNWCCYLKTAISDIEV--------EFEEIEKPT---KITIPGY--DKKVEVGVL--------------WH-- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 224 ssglqFGFKIADeclkacNGIQEIEVFTTRADTIYGVTYIAIAPEHPLVEHaikqvsqevskmikailnttqreralekk 303
Cdd:PTZ00419 243 -----FAYPLED------SGQEEIVVATTRIETMLGDVAVAVHPKDERYKK----------------------------- 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 304 gaFLGIYAIHPLTK-QKIPVwVANFALA--NYGSGALMGVPACDERDFEFANLYHIPIKVITQSpqnlphtKEEVLKNSG 380
Cdd:PTZ00419 283 --LHGKELIHPFIPdRKIPI-IADDELVdmEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFTL-------DGKINENGG 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 381 EWSDLSSSVAREQIIAYFEKENL------------------------------------GKRVIN--------------- 409
Cdd:PTZ00419 353 EFAGMHRFDCRRKIEEELKEMGLlrdkvpnpmrlprcsrsgdivepmlipqwyvnckdmAKRAVEavrngelkiipsshe 432
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 410 ---YR----LQDWGVSRQRYWGAPIPMIHCNHCGIVPETQlpvtlPED--IVIDGEGNPLEKhASWKFtQCPKCHKNALR 480
Cdd:PTZ00419 433 nvwYHwlenIQDWCISRQLWWGHRIPAYRVISKGPETDPS-----DEEpwVVARSEEEALEK-AKKKF-GLSEEDFELEQ 505
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 481 ETDTMDTFIQSS-WYFLRYTTPknqreNQAFDqnyLKYFMPVDTYIGGieHAILHLLYARFFTKALRDLGYLhldePFKQ 559
Cdd:PTZ00419 506 DEDVLDTWFSSGlFPFSTLGWP-----DQTDD---LQRFFPTSLLETG--SDILFFWVARMVMMSLHLTDKL----PFKT 571
|
650 660 670
....*....|....*....|....*....|
gi 3024678 560 LITQGMVL-KNGAKMSKSKGNVVSPKEILK 588
Cdd:PTZ00419 572 VFLHAMVRdSQGEKMSKSKGNVIDPLEVIE 601
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
32-228 |
7.51e-28 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 119.06 E-value: 7.51e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 32 YILSMLPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMPAENAAIKHGIHPKTWTYENIENMQKEFEAL 111
Cdd:COG0143 4 LVTTAIPYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGITPQELVDRIHAEFKELFEKL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 112 GFSFSKnreFA-TSDPDYTKFEQRFFIDLWEKGLIYRKK-----------------------------AMLNWCPNDKTV 161
Cdd:COG0143 84 GISFDN---FIrTTSPEHKELVQEIFQRLYDNGDIYKGEyegwycpecerflpdryvegtcpkcgaedAYGDQCENCGAT 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3024678 162 LANEQVIDGRCWRCDTEVIQKELYQYYLKITNYAEELLKDLEALEDhWPSQVLIMQKNWIgkSSGLQ 228
Cdd:COG0143 161 LEPTELINPRSAISGAPPELREEEHYFFRLSKYQDRLLEWIEENPD-IQPEVRNEVLSWL--KEGLQ 224
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
32-236 |
3.60e-26 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 111.61 E-value: 3.60e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 32 YILSMLPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMPAENAAIKHGIHPKTWTYENIENMQKEFEAL 111
Cdd:pfam09334 2 LVTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITPEELVDRYHEIHREDFKKF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 112 GFSFSKnreFA-TSDPDYTKFEQRFFIDLWEKGLIYRKKAMLNWCPNDKTVLANEQV----------------------- 167
Cdd:pfam09334 82 NISFDD---YGrTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVegtcphcgsedargdqcencgrh 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 168 ------IDGRCWRCDTEVIQKELYQYYLKITNYAEELLKDLEALEDHWPSQVLIMQKNWIGK-------SSGLQFGFKIA 234
Cdd:pfam09334 159 leptelINPKCVICGTTPEVKETEHYFFDLSKFQDKLREWIEENNPEWPENVKNMVLEWLKEglkdraiSRDLDWGIPVP 238
|
..
gi 3024678 235 DE 236
Cdd:pfam09334 239 GA 240
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
400-609 |
3.89e-24 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 104.24 E-value: 3.89e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 400 KENLGKRVINYRlqDWGVSRQRYWGAPIPMIHCNHCGivpetqlpvtlpEDIVIdgegnplekhaswkftqcpkchknal 479
Cdd:cd00818 179 KNRFGNWLENRR--DWCISRQRYWGTPIPVWYCEDCG------------EVLVR-------------------------- 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 480 RETDTMDTFIQS--SWYF-LRYttpknQRENQAFDQNYlkyfmPVDTYIGGIEHA-----ILHLLYARFFTKAlrdlgyl 551
Cdd:cd00818 219 RVPDVLDVWFDSgsMPYAqLHY-----PFENEDFEELF-----PADFILEGSDQTrgwfySLLLLSTALFGKA------- 281
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 3024678 552 hldePFKQLITQGMVL-KNGAKMSKSKGNVVSPKEILKKYGADAARLFILFAAPPAKEL 609
Cdd:cd00818 282 ----PYKNVIVHGFVLdEDGRKMSKSLGNYVDPQEVVDKYGADALRLWVASSDVYAEDL 336
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
30-207 |
4.70e-23 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 103.81 E-value: 4.70e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 30 KKYILSM-LPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMPAENAAIKHGIHPKTWTYENIENMQKEF 108
Cdd:PRK11893 1 KKFYITTpIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAGISPQELADRNSAAFKRLW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 109 EALGFSFSKnreFA-TSDPDYTKFEQRFFIDLWEKGLIYrKKAMLNW-CPNDKTVLANEQVIDG--RCWRCDTEVIQKEL 184
Cdd:PRK11893 81 EALNISYDD---FIrTTDPRHKEAVQEIFQRLLANGDIY-LGKYEGWyCVRCEEFYTESELIEDgyRCPPTGAPVEWVEE 156
|
170 180
....*....|....*....|...
gi 3024678 185 YQYYLKITNYAEELLKDLEALED 207
Cdd:PRK11893 157 ESYFFRLSKYQDKLLELYEANPD 179
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
5-587 |
6.10e-22 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 101.90 E-value: 6.10e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 5 NIEKKWQEFWWKNKSFepKDDFNLPKKYILSMLPYP--SGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMPA 82
Cdd:PLN02381 104 AVEKSWYAWWEKSGYF--GADAKSSKPPFVIVLPPPnvTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIAT 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 83 ----------ENAAIKHGIHPKT-------WTYENIENMQKEFEALGFSFSKNREFATSDPDYTKFEQRFFIDLWEKGLI 145
Cdd:PLN02381 182 qvvvekklmrERHLTRHDIGREEfvsevwkWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLI 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 146 YRKKAMLNWCPNDKTVLANEQVidgrcwrcDTEVIQKELyqyYLKITNYAEellkdlealedhwPSQVlimqknwigkss 225
Cdd:PLN02381 262 YRDIRLVNWDCTLRTAISDVEV--------DYIDIKERT---LLKVPGYDK-------------PVEF------------ 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 226 GLQFGFKIADEclkacNGIQEIEVFTTRADTIYGVTYIAIAPEHPLVEHaikqvsqevskmikailnttqreralekkga 305
Cdd:PLN02381 306 GVLTSFAYPLE-----GGLGEIVVATTRIETMLGDTAIAIHPDDERYKH------------------------------- 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 306 FLGIYAIHPLTKQKIPVWV-ANFALANYGSGALMGVPACDERDF--------EFANLYHIPIKVITQSPQN---LPHTKE 373
Cdd:PLN02381 350 LHGKFAVHPFNGRKLPIICdAILVDPNFGTGAVKITPAHDPNDFevgkrhnlEFINIFTDDGKINSNGGSEfagMPRFAA 429
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 374 -----EVLKNSG----------------------------EWSDLSSSVAREQIIAYFEKENLGKRVIN-------YR-- 411
Cdd:PLN02381 430 reaviEALQKKGlyrgaknnemrlglcsrtndvvepmikpQWFVNCSSMAKQALDAAIDGENKKLEFIPkqylaewKRwl 509
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 412 --LQDWGVSRQRYWGAPIPMIHcnhcgivpetqlpVTLPED------------IVIDGEGNPLEKhASWKFtqcPKCHKN 477
Cdd:PLN02381 510 enIRDWCISRQLWWGHRIPAWY-------------VTLEDDqlkelgsyndhwVVARNESDALLE-ASQKF---PGKKFE 572
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 478 ALRETDTMDTFIQSSWYFLRYTTPKNqrenqafDQNYLKYFMPVDTYIGGieHAILHLLYARFFTKALRdlgyLHLDEPF 557
Cdd:PLN02381 573 LSQDPDVLDTWFSSGLFPLSVLGWPD-------DTDDLKAFYPTSVLETG--HDILFFWVARMVMMGMQ----LGGDVPF 639
|
650 660 670
....*....|....*....|....*....|.
gi 3024678 558 KQLITQGMVLK-NGAKMSKSKGNVVSPKEIL 587
Cdd:PLN02381 640 RKVYLHPMIRDaHGRKMSKSLGNVIDPLEVI 670
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
2-628 |
1.56e-20 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 97.32 E-value: 1.56e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 2 DFINIEKKWQefWWKNKSFEPKDDFNLPKKYILSMLPyP--SGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFG 79
Cdd:PLN02943 62 DFTSEERIYN--WWESQGYFKPNFDRGGDPFVIPMPP-PnvTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAG 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 80 MPA----ENAAIKHGIH----------PKTWTYE-----NIENMQKEfeaLGFSFSKNREFATSDPDYTKFEQRFFIDLW 140
Cdd:PLN02943 139 IATqlvvEKMLASEGIKrtdlgrdeftKRVWEWKekyggTITNQIKR---LGASCDWSRERFTLDEQLSRAVVEAFVRLH 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 141 EKGLIYRKKAMLNWCPNDKTVLAneqvidgrcwrcDTEViqkelyqyylkitNYAEEllkdlealedhwPSQVLIMQKNW 220
Cdd:PLN02943 216 EKGLIYQGSYMVNWSPNLQTAVS------------DLEV-------------EYSEE------------PGTLYYIKYRV 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 221 IGKSSGLqfgfkiadeclkacngiqeIEVFTTRADTIYGVTYIAIAPEHplvehaiKQVSQEVSKMikailnttqreral 300
Cdd:PLN02943 259 AGGSEDF-------------------LTIATTRPETLFGDVAIAVNPED-------DRYSKYIGKM-------------- 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 301 ekkgaflgiyAIHPLT-KQKIPVWVANFALANYGSGALMGVPACDERDFEFANLYHIPIKVITQSPQNL----------- 368
Cdd:PLN02943 299 ----------AIVPMTyGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLnevaglywfea 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 369 ------------------PHTKE--------EVLKN--SGEWSDLSSSVAREQIIAYFEKE-----NLGKRVINYRL--- 412
Cdd:PLN02943 369 reklwsdleetglavkkePHTLRvprsqrggEVIEPlvSKQWFVTMEPLAEKALKAVENGEltiipERFEKIYNHWLsni 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 413 QDWGVSRQRYWGAPIPM--IHCNHCgivpetqlpvtlPED-IVIDGEGNPLEKhASWKFTQCPKCHKnalrETDTMDTFI 489
Cdd:PLN02943 449 KDWCISRQLWWGHRIPVwyIVGKDC------------EEDyIVARSAEEALEK-AREKYGKDVEIYQ----DPDVLDTWF 511
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 490 QSS-WYFLRYTTPKNQRENqafdqnyLKYFMPVDTYIGGieHAILHLLYARFFTKALRDLGYLhldePFKQLITQGMVL- 567
Cdd:PLN02943 512 SSAlWPFSTLGWPDVSAED-------FKKFYPTTVLETG--HDILFFWVARMVMMGIEFTGTV----PFSYVYLHGLIRd 578
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3024678 568 KNGAKMSKSKGNVVSPKEILKKYGADAARlFILFAAPPAKELEWNDSALEGAHRFIKRLYD 628
Cdd:PLN02943 579 SQGRKMSKTLGNVIDPLDTIKEFGTDALR-FTLALGTAGQDLNLSTERLTSNKAFTNKLWN 638
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
611-727 |
2.15e-19 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 84.19 E-value: 2.15e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 611 WNDSALEGAHRFIKRLYDKANAINPTTSKPEFKEvSLNEAQKLGRKKVYEALKKSHEIFNKaesaYSFNTLIASCMEALN 690
Cdd:cd07958 1 WSDSGVEGAYRFLNRVWRLVTELAEALAAPAAAA-ELSEEDKELRRKLHKTIKKVTEDIER----LRFNTAIAALMELVN 75
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 3024678 691 ALSA-----QNNERILCEGYFVLLQILEPIIPHTAWELSERL 727
Cdd:cd07958 76 ALYKykkkdAQHAAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
29-236 |
9.11e-17 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 84.82 E-value: 9.11e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 29 PKKY-ILSMLPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMPAENAAIKHGIHPKtwtyENIENMQKE 107
Cdd:PRK00133 1 MRKIlVTCALPYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKEGITPE----ELIARYHAE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 108 ----FEALGFSF----SknrefaTSDPDYTKFEQRFFIDLWEKGLIYRKKAMLNWCPNDKTVL-------------ANEQ 166
Cdd:PRK00133 77 hkrdFAGFGISFdnygS------THSEENRELAQEIYLKLKENGYIYEKTIEQLYDPEKGMFLpdrfvkgtcpkcgAEDQ 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 167 ----------------VIDGRCWRCDTEVIQKELYQYYLKITNYaEELLKDLEALEDHWPSQVLIMQKNWIgkSSGLQ-- 228
Cdd:PRK00133 151 ygdncevcgatyspteLINPKSAISGATPVLKESEHFFFKLPRF-EEFLKEWITRSGELQPNVANKMKEWL--EEGLQdw 227
|
250
....*....|....*.
gi 3024678 229 --------FGFKIADE 236
Cdd:PRK00133 228 disrdapyFGFEIPGA 243
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
564-662 |
8.41e-16 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 80.92 E-value: 8.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 564 GMVLKNGAKMSKSKGNVVSPKEILKKYGADAARLFILfAAPPAKELEWNDSALEGAHRFIKRLYDKANAINPTTSKPEFK 643
Cdd:COG0215 257 GFLTVNGEKMSKSLGNFFTVRDLLKKYDPEVLRFFLL-SAHYRSPLDFSEEALEEAEKALERLYNALRRLEEALGAADSS 335
|
90
....*....|....*....
gi 3024678 644 EVSLNEAqklgRKKVYEAL 662
Cdd:COG0215 336 AEEIEEL----REEFIAAM 350
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
7-599 |
1.04e-15 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 81.74 E-value: 1.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 7 EKKWQEFWWKNKSFEPKDDFNLPKKYIL-SMLPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMPAE-- 83
Cdd:PLN02843 9 EPEIQKLWEENQVYKRVSDRNNGESFTLhDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIElk 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 84 -----NAAIKHGIHP-------KTWTYENIENMQKEFEALGFSFSKNREFATSDPDYTKFEQRFFIDLWEKGLIYRKKAM 151
Cdd:PLN02843 89 vlqslDQEARKELTPiklrakaAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRKP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 152 LNWCPNDKTVLANeqvidgrcwrcdteviqkelyqyylkitnyAEellkdLEALEDHWPSQV-LIMQKNWIGKSSGLQFG 230
Cdd:PLN02843 169 VHWSPSSRTALAE------------------------------AE-----LEYPEGHVSKSIyVAFPVVSPSETSPEELE 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 231 FKIADECLKacngiqeieVFTTRADTIYGVTYIAIAP-------EHPLVEHAIKQVSQEVSKMIKAILNTTQRER----- 298
Cdd:PLN02843 214 EFLPGLSLA---------IWTTTPWTMPANAAVAVNDklqysvvEVQSFSEDESTSGGNKKKRPGNVLKEQQKLFlivat 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 299 ----ALEKK--------GAFLG------IYaIHPLTKQKIPVWVA-NFALANYGSGALMGVPACDERDFEFANLYHIPI- 358
Cdd:PLN02843 285 dlvpALEAKwgvklvvlKTFPGsdlegcRY-IHPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLl 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 359 ---------------------------KVITQSPQNLPHTKEEVL--KNSGEWSDLSSSVAR--EQIIAYFE-------- 399
Cdd:PLN02843 364 spvddagkfteeagqfsglsvlgegnaAVVEALDEAGSLLMEEAYghKYPYDWRTKKPTIFRatEQWFASVEgfrqaald 443
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 400 -----------KENLGKRVINYRlQDWGVSRQRYWGAPIPMIHcnHCgivpETQLPVTLPEDI-----VIDGEGNplekH 463
Cdd:PLN02843 444 aidkvkwipaqGENRIRAMVSGR-SDWCISRQRTWGVPIPVFY--HV----ETKEPLMNEETIahvksIVAQKGS----D 512
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 464 ASWKFTQ---CPKCHKNA----LRETDTMDTFIQS--SWyflryTTPKNQRENQAFdqnylkyfmPVDTYIGG------- 527
Cdd:PLN02843 513 AWWYMDVedlLPEKYRDKasdyEKGTDTMDVWFDSgsSW-----AGVLGSREGLSY---------PADLYLEGsdqhrgw 578
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 528 IEHAILHLLYARffTKAlrdlgylhldePFKQLITQGMVL-KNGAKMSKSKGNVVSPKEIL-----KK----YGADAARL 597
Cdd:PLN02843 579 FQSSLLTSVATK--GKA-----------PYKSVLTHGFVLdEKGFKMSKSLGNVVDPRLVIeggknQKqepaYGADVLRL 645
|
..
gi 3024678 598 FI 599
Cdd:PLN02843 646 WV 647
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
29-200 |
2.55e-14 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 76.76 E-value: 2.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 29 PKKYILSMLPYPSGEIHMGHVrnYT--IGDALARYYRLHHYNVLHPMGFDSFGMPAENAAIKHGIHPKTWTYENIENMQK 106
Cdd:PRK12267 4 KTFYITTPIYYPNGKPHIGHA--YTtiAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGKTPQEYVDEISAGFKE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 107 EFEALGFSFSKnreFA-TSDPDYTKFEQRFFIDLWEKGLIYRKKAMLNWCPNDKTVLANEQVID-GRCWRCDTEVIQKEL 184
Cdd:PRK12267 82 LWKKLDISYDK---FIrTTDERHKKVVQKIFEKLYEQGDIYKGEYEGWYCVSCETFFTESQLVDgGKCPDCGREVELVKE 158
|
170
....*....|....*.
gi 3024678 185 YQYYLKITNYAEELLK 200
Cdd:PRK12267 159 ESYFFRMSKYQDRLLE 174
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
511-794 |
1.79e-12 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 70.98 E-value: 1.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 511 DQNYLKYFmPVDTYIGGIEhaIL--HLLYARFFTKALrDLgylhldEPFKQLITQGMVLKNGAKMSKSKGNVVSPKEILK 588
Cdd:PRK12267 246 DELFKKFW-PADVHLVGKD--ILrfHAIYWPIMLMAL-GL------PLPKKVFAHGWWLMKDGKMSKSKGNVVDPEELVD 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 589 KYGADAARLFILFAAPPAkelewNDSAL-EGAhrFIKRL-YDKAN-------------------AINPTTSKPEFKEVSL 647
Cdd:PRK12267 316 RYGLDALRYYLLREVPFG-----SDGDFsPEA--LVERInSDLANdlgnllnrtvaminkyfdgEIPAPGNVTEFDEELI 388
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 648 NEAQKLgRKKVYEALKKSHeiFNKA-ESAYSF----NTLIASCM-----------EALNALSAqnnerILCEGYFVLLQI 711
Cdd:PRK12267 389 ALAEET-LKNYEELMEELQ--FSRAlEEVWKLisraNKYIDETApwvlakdegkkERLATVMY-----HLAESLRKVAVL 460
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 712 LEPIIPHTawelSERLFKRENFKPiaidEDALMEDFMTLGLTINGKR---------RAELKVNINASKEEIIVLAKKELE 782
Cdd:PRK12267 461 LSPFMPET----SKKIFEQLGLEE----ELTSWESLLEWGGLPAGTKvakgeplfpRIDVEEEIAYIKEQMEGSAPKEPE 532
|
330
....*....|..
gi 3024678 783 KyLENASVKKEI 794
Cdd:PRK12267 533 E-KEKKPEKPEI 543
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
414-600 |
2.22e-12 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 70.91 E-value: 2.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 414 DWGVSRQRYWGAPIPmIHCNHCGivpetqlpvtlpEDIVIDGEGNPLEKHASWKFTQCPKCHKNAL-------------- 479
Cdd:PLN02882 466 DWAVSRSRFWGTPLP-IWISDDG------------EEVVVIGSIAELEKLSGVKVTDLHRHFIDHItipssrgpefgvlr 532
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 480 RETDTMDTFIQSSwyflryTTPKNQR----ENQA-FDQNYlkyfmPVDTYIGGIEHAilhllYARFFTkaLRDLGYLHLD 554
Cdd:PLN02882 533 RVDDVFDCWFESG------SMPYAYIhypfENKElFEKNF-----PADFVAEGLDQT-----RGWFYT--LMVLSTALFD 594
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 3024678 555 EP-FKQLITQGMVL-KNGAKMSKSKGNVVSPKEILKKYGADAARLFIL 600
Cdd:PLN02882 595 KPaFKNLICNGLVLaEDGKKMSKSLKNYPDPNEVIDKYGADALRLYLI 642
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
558-727 |
4.39e-11 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 66.29 E-value: 4.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 558 KQLITQGMVLKNGAKMSKSKGNVVSPKEILKKYGADAARLFILFAAPPAKELEWNDSALEG-------------AHR--- 621
Cdd:COG0143 313 KKVFAHGFLTVEGEKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPFGQDGDFSWEDFVArvnsdlandlgnlASRtls 392
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 622 FIKRLYDkaNAInpttskPEFKEVSLNEaqklgrKKVYEALKKSHEIFNKAESAYSFNTLIASCME---ALN-------- 690
Cdd:COG0143 393 MIHKYFD--GKV------PEPGELTEAD------EELLAEAEAALEEVAEAMEAFEFRKALEEIMAlarAANkyidetap 458
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 3024678 691 -ALSAQNNERILCEGYFVLLQI-------LEPIIPHTAWELSERL 727
Cdd:COG0143 459 wKLAKDEDPERLATVLYTLLEAlrilailLKPFLPETAEKILEQL 503
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
530-607 |
2.41e-09 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 59.47 E-value: 2.41e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3024678 530 HAIlhllyarFFTKALRDLGYlhldEPFKQLITQGMVLKNGAKMSKSKGNVVSPKEILKKYGADAARLFILFAAPPAK 607
Cdd:cd00814 249 HAI-------YWPAMLLGAGL----PLPTRIVAHGYLTVEGKKMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGK 315
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
413-600 |
5.19e-08 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 56.90 E-value: 5.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 413 QDWGVSRQRYWGAPIPmIHCNhcgivpETQLPVTLPEDIV----IDGEGNPLEKHASW---------KFTQCPKCHknal 479
Cdd:PTZ00427 569 KDWCISRNRYWGTPIP-IWAD------EKMETVICVESIKhleeLSGVKNINDLHRHFidhieiknpKGKTYPKLK---- 637
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 480 RETDTMDTFIQS-SWYFLRYTTPKNQRENqafdqNYLKYFmPVDTYIGGIEHA-----ILHLLYARFFTKAlrdlgylhl 553
Cdd:PTZ00427 638 RIPEVFDCWFESgSMPYAKVHYPFSTEKE-----DFHKIF-PADFIAEGLDQTrgwfyTLLVISTLLFDKA--------- 702
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 3024678 554 dePFKQLITQGMVL-KNGAKMSKSKGNVVSPKEILKKYGADAARLFIL 600
Cdd:PTZ00427 703 --PFKNLICNGLVLaSDGKKMSKRLKNYPDPLYILDKYGADSLRLYLI 748
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
564-600 |
9.25e-08 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 53.35 E-value: 9.25e-08
10 20 30
....*....|....*....|....*....|....*..
gi 3024678 564 GMVLKNGAKMSKSKGNVVSPKEILKKYGADAARLFIL 600
Cdd:cd00672 166 GHLTIDGEKMSKSLGNFITVRDALKKYDPEVLRLALL 202
|
|
| PLN02610 |
PLN02610 |
probable methionyl-tRNA synthetase |
33-176 |
1.02e-07 |
|
probable methionyl-tRNA synthetase
Pssm-ID: 215329 [Multi-domain] Cd Length: 801 Bit Score: 55.56 E-value: 1.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 33 ILSMLPYPSGEIHMGHVrnytIG-----DALARYYRLHHYNVLHPMGFDSFGMPAENAAIKHGIHPKTW--TYENIENmq 105
Cdd:PLN02610 21 ITSALPYVNNVPHLGNI----IGcvlsaDVFARYCRLRGYNAIYICGTDEYGTATETKALEENCTPKEIcdKYHAIHK-- 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3024678 106 KEFEALGFSFSKnreFA-TSDPDYTKFEQRFFIDLWEKGLIYRKKAMLNWCPNDKTVLANEQVIdGRCWRCD 176
Cdd:PLN02610 95 EVYDWFDISFDK---FGrTSTPQQTEICQAIFKKLMENNWLSENTMQQLYCDTCQKFLADRLVE-GTCPTEG 162
|
|
| lysK |
PRK00750 |
lysyl-tRNA synthetase; Reviewed |
567-628 |
3.59e-07 |
|
lysyl-tRNA synthetase; Reviewed
Pssm-ID: 234829 [Multi-domain] Cd Length: 510 Bit Score: 53.66 E-value: 3.59e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3024678 567 LKNGAKMSKSKGNVVSPKEILKKYGADAARLFiLFAAP-PAKELEWNdsalegahrFIKRLYD 628
Cdd:PRK00750 275 DKKGEKISKSKGNVITIEDWLEYAPPESLRLF-MFARPkPAKRLDFD---------VIPKLVD 327
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
4-88 |
5.62e-07 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 53.53 E-value: 5.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 4 INIEKKWQEFWWKNKSFEPKDDFNLPK---KYIlSMLPYP--SGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSF 78
Cdd:PLN02959 16 LEIEVAVQKWWEEEKVFEAEAGDEPPKpgeKFF-GNFPYPymNGLLHLGHAFSLSKLEFAAAYHRLRGANVLLPFAFHCT 94
|
90
....*....|
gi 3024678 79 GMPAENAAIK 88
Cdd:PLN02959 95 GMPIKASADK 104
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
38-109 |
5.25e-06 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 46.70 E-value: 5.25e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3024678 38 PYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMPAENAAIKHGIHPKTWTYENIENMQKEFE 109
Cdd:cd00802 6 ITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAGGLIGDPANKKGENAKAFVERWIERIKEDVE 77
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
562-744 |
1.19e-05 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 48.91 E-value: 1.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 562 TQGMVLKNGAKMSKSKGNVVSPKEILKKYGADAARL-------------FILFAAPPA-----KELEWNDSALEGA---- 619
Cdd:PLN02959 708 CNGHLMLNSEKMSKSTGNFLTLRQAIEEFSADATRFaladagdgvddanFVFETANAAilrltKEIAWMEEVLAAEsslr 787
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 620 ----HRFIKRLYdkANAINpttskpefkeVSLNEAQKLGRKKVY-EALKKSHEIFNKAESAYSFntliaSCMealnalSA 694
Cdd:PLN02959 788 tgppSTYADRVF--ENEIN----------IAIAETEKNYEAMMFrEALKSGFYDLQAARDEYRL-----SCG------SG 844
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 3024678 695 QNNERILCEGYFVLLQILEPIIPHTAWELSERLFKRENFK-----PIAIDEDALM 744
Cdd:PLN02959 845 GMNRDLVWRFMDVQTRLITPICPHYAEHVWREILKKEGFAvtagwPVAGEPDLTL 899
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
558-624 |
1.34e-05 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 48.56 E-value: 1.34e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3024678 558 KQLITQGMVLKNGAKMSKSKGNVVSPKEILKKYGADAARLFILfaappaKELEWNDSALEGAHRFIK 624
Cdd:PLN02224 352 KMVFGHGFLTKDGMKMGKSLGNTLEPFELVQKFGPDAVRYFFL------REVEFGNDGDYSEDRFIK 412
|
|
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
569-713 |
1.60e-05 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 48.49 E-value: 1.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 569 NGAKMSKSKGNVVSPKEILKKYGADAARlfILFAAPP-AKELEWNDSALEGA-------HRFIKRLYDKANAINPTTSKP 640
Cdd:PTZ00399 312 KGLKMSKSLKNFITIRQALSKYTARQIR--LLFLLHKwDKPMNYSDESMDEAiekdkvfFNFFANVKIKLRESELTSPQK 389
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3024678 641 EF-KEVSLNEAQKLGRKKVYEALKKsheifnkaesaySFNTliASCMEALNALSAQNNERILCEGYFVLLQILE 713
Cdd:PTZ00399 390 WTqHDFELNELFEETKSAVHAALLD------------NFDT--PEALQALQKLISATNTYLNSGEQPSAPLLRS 449
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
647-774 |
3.99e-05 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 44.32 E-value: 3.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 647 LNEAQKLgRKKVYEALKKsheifnkaesaYSFNTLIASCME-ALNALS----------------AQNNERILCEGYFVLL 709
Cdd:pfam08264 5 LSRLNKL-IKEVTEAYEN-----------YRFNTAAQALYEfFWNDLSdwylelikdrlygeepDSRAQTTLYEVLETLL 72
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3024678 710 QILEPIIPHTAWELSERLF-KRENFKPIAIDEDALMEDFMTLGLTI---NGKRRAELKVNINASKEEII 774
Cdd:pfam08264 73 RLLAPFMPFITEELWQKESiHLAPWPEDAELEEAELEEAFELRQEIvqaIRKLRSELKIKKSLPLEVVI 141
|
|
| tRNA-synt_1f |
pfam01921 |
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from ... |
567-628 |
1.11e-04 |
|
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from prokaryotes.
Pssm-ID: 396483 Cd Length: 357 Bit Score: 45.33 E-value: 1.11e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3024678 567 LKNGAKMSKSKGNVVSPKEILKKYGADAARLFIlFAAPPAKELewnDSALEGahrfIKRLYD 628
Cdd:pfam01921 274 LKGGGKMSSSKGNVITPEDWLEYAPPESLRFLM-FRTKPKKAK---DLDFDV----IPRLVD 327
|
|
| LysRS_core_class_I |
cd00674 |
catalytic core domain of class I lysyl tRNA synthetase; Class I lysyl tRNA synthetase (LysRS) ... |
567-628 |
2.29e-04 |
|
catalytic core domain of class I lysyl tRNA synthetase; Class I lysyl tRNA synthetase (LysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The class I LysRS is found only in archaea and some bacteria and has evolved separately from class II LysRS, as the two do not share structural or sequence similarity.
Pssm-ID: 173900 [Multi-domain] Cd Length: 353 Bit Score: 44.24 E-value: 2.29e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3024678 567 LKNGAKMSKSKGNVVSPKEILKKYGADAARLFILFAAPPAKELEWNDSalegahrfIKRLYD 628
Cdd:cd00674 270 LKGGGKMSSSKGNVITPSDWLEVAPPEVLRYLYARRKNPEKHIGFDLD--------ILRLYD 323
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
37-228 |
2.74e-04 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 44.32 E-value: 2.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 37 LPYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMPAENAAIKHGIHPKtwtyENIENMQKEFEAL--GFS 114
Cdd:PLN02224 77 LYYVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGEKIATSAAANGRNPP----EHCDIISQSYRTLwkDLD 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 115 FSKNREFATSDPDYTKFEQRFFIDLWEKGLIYRKKAMLNWCPNDKTVLANEQVIDGRCwrCDTE---VIQKELYQYYLKI 191
Cdd:PLN02224 153 IAYDKFIRTTDPKHEAIVKEFYARVFANGDIYRADYEGLYCVNCEEYKDEKELLENNC--CPVHqmpCVARKEDNYFFAL 230
|
170 180 190
....*....|....*....|....*....|....*....
gi 3024678 192 TNYaEELLKDLEALEDHW--PSQVLIMQKNWIgkSSGLQ 228
Cdd:PLN02224 231 SKY-QKPLEDILAQNPRFvqPSYRLNEVQSWI--KSGLR 266
|
|
| cysS |
PRK14535 |
cysteinyl-tRNA synthetase; Provisional |
558-627 |
2.80e-04 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 173001 [Multi-domain] Cd Length: 699 Bit Score: 44.32 E-value: 2.80e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 558 KQLITQGMVLKNGAKMSKSKGNVVSPKEILKKYGADAARLFILfAAPPAKELEWNDSALEGAHRFIKRLY 627
Cdd:PRK14535 494 KYWLHNGFIRVDGEKMSKSLGNFFTIREVLKQYDPEVVRFFIL-RAHYRSPLNYSDAHLDDAKGALTRLY 562
|
|
| ArgRS_core |
cd00671 |
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic ... |
38-70 |
8.21e-04 |
|
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. There are at least three subgroups of ArgRS. One type contains both characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The second subtype lacks the KMSKS motif; however, it has a lysine N-terminal to the HIGH motif, which serves as the functional counterpart to the second lysine of the KMSKS motif. A third group, which is found primarily in archaea and a few bacteria, lacks both the KMSKS motif and the HIGH loop lysine.
Pssm-ID: 185675 [Multi-domain] Cd Length: 212 Bit Score: 41.40 E-value: 8.21e-04
10 20 30
....*....|....*....|....*....|...
gi 3024678 38 PYPSGEIHMGHVRNYTIGDALARYYRLHHYNVL 70
Cdd:cd00671 9 ANPTGPLHVGHLRNAIIGDSLARILEFLGYDVT 41
|
|
| LysS |
COG1384 |
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA ... |
567-604 |
1.03e-03 |
|
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA synthetase, class I is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440994 [Multi-domain] Cd Length: 525 Bit Score: 42.49 E-value: 1.03e-03
10 20 30
....*....|....*....|....*....|....*...
gi 3024678 567 LKNGAKMSKSKGNVVSPKEILkKYGADAARLFILFAAP 604
Cdd:COG1384 282 DENGEKISKSKGNGLTVEEWL-EYAEPESLRYFMFRKP 318
|
|
| argS |
TIGR00456 |
arginyl-tRNA synthetase; This model recognizes arginyl-tRNA synthetase in every completed ... |
38-70 |
1.44e-03 |
|
arginyl-tRNA synthetase; This model recognizes arginyl-tRNA synthetase in every completed genome to date. An interesting feature of the alignment of all arginyl-tRNA synthetases is a fairly deep split between two families. One family includes archaeal, eukaryotic and organellar, spirochete, E. coli, and Synechocystis sp. The second, sharing a deletion of about 25 residues in the central region relative to the first, includes Bacillus subtilis, Aquifex aeolicus, the Mycoplasmas and Mycobacteria, and the Gram-negative bacterium Helicobacter pylori. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273085 [Multi-domain] Cd Length: 563 Bit Score: 41.94 E-value: 1.44e-03
10 20 30
....*....|....*....|....*....|...
gi 3024678 38 PYPSGEIHMGHVRNYTIGDALARYYRLHHYNVL 70
Cdd:TIGR00456 121 ANPAGPLHVGHLRNAIIGDSLARILEFLGYDVI 153
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
42-112 |
2.96e-03 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 40.86 E-value: 2.96e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3024678 42 GEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGF----DSFgmpaENAAIKHGIHPKTWTYENIENMQKEFEALG 112
Cdd:COG0215 34 DYAHIGHARTFVVFDVLRRYLRYLGYKVTYVRNItdvdDKI----IKRAAEEGESIWELAERYIAAFHEDMDALG 104
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
564-743 |
4.07e-03 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 40.52 E-value: 4.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 564 GMVLKNGAKMSKSKGNVVSPKEILKKYGADAARLFILFAAPPAKE---LEWND------SALEG-----AHR---FIKRL 626
Cdd:PRK00133 321 GFLTVEGAKMSKSRGTFIWARTYLDHLDPDYLRYYLAAKLPETIDdldFNWEDfqqrvnSELVGkvvnfASRtagFINKR 400
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3024678 627 YDkanainpttskpefKEVSLNEAQklgrKKVYEALKKSHEIFNKAESAYSFNTLIASCMealnALSAQNNERI------ 700
Cdd:PRK00133 401 FD--------------GKLPDALAD----PELLEEFEAAAEKIAEAYEAREFRKALREIM----ALADFANKYVddnepw 458
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3024678 701 ------------LCegyFVLLQI-------LEPIIPHTAwelsERLFKRENFKPIAIDEDAL 743
Cdd:PRK00133 459 klakqdgerlqaVC---SVGLNLfralaiyLKPVLPELA----ERAEAFLNLEELTWDDAQQ 513
|
|
| argS |
PRK01611 |
arginyl-tRNA synthetase; Reviewed |
3-69 |
5.09e-03 |
|
arginyl-tRNA synthetase; Reviewed
Pssm-ID: 234964 [Multi-domain] Cd Length: 507 Bit Score: 40.14 E-value: 5.09e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3024678 3 FINIEKKwQEFWWK--NKSFEPKDDF-----NLPKKYIL---SmlPYPSGEIHMGHVRNYTIGDALARYYRLHHYNV 69
Cdd:PRK01611 78 FINFFLD-PAALAElvLAILEAGERYgrsdiGKGKKVVVeyvS--ANPTGPLHVGHLRSAVIGDALARILEFAGYDV 151
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
38-112 |
6.23e-03 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 38.71 E-value: 6.23e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3024678 38 PYPSGEIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMPAENAAIKHGIHPKTWTYENIENMQKEFEALG 112
Cdd:cd00672 28 PTVYDYAHIGHARTYVVFDVLRRYLEDLGYKVRYVQNITDIDDKIIKRAREEGLSWKEVADYYTKEFFEDMKALN 102
|
|
| |
