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RecName: Full=Solute carrier family 12 member 1; AltName: Full=Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; Short=BSC1; AltName: Full=Kidney-specific Na-K-Cl symporter; AltName: Full=Na-K-2Cl cotransporter 2; Short=NKCC2
Protein Classification
solute carrier family 12 protein ( domain architecture ID 11489985 )
solute carrier family 12 protein similar to Arabidopsis thaliana cation-chloride cotransporter 1, which mediates both potassium-chloride and sodium-chloride cotransports and is involved in plant development and Cl(-) homeostasis
List of domain hits
Name
Accession
Description
Interval
E-value
2a30
TIGR00930 K-Cl cotransporter; [Transport and binding proteins, Other]
100-1095
0e+00
K-Cl cotransporter; [Transport and binding proteins, Other]
Pssm-ID: 273347 [Multi-domain]
Cd Length: 953
Bit Score: 1540.43
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 100 NT M DAVP K IE Y YRN TGSVS GPK V NRPSL Q E I H EQ L A K N V AVAPGS AD RVA NG D GM PGD E Q AE N ---- KE EDVT G V VKFGW 175
Cdd:TIGR00930 1 NT V DAVP R IE H YRN SEGQG GPK R NRPSL E E L H DL L D K V V SLLGPL AD YTN NG Q GM KEH E E AE D aegt KE KPPA G A VKFGW 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 176 V K GVLV R C M LNIWGV M LF I RLSWIVG E AGIGL GVI II G L SVV VTT L TG I SMSAI C TNGVV R GGGAYYLISRSLGPEFGGS 255
Cdd:TIGR00930 81 V M GVLV P C L LNIWGV I LF L RLSWIVG Q AGIGL SLL II L L CCC VTT I TG L SMSAI A TNGVV K GGGAYYLISRSLGPEFGGS 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 256 IGLIF R FANAV R VAMYVVGFAETV V DLL K E SD S - M MVDP T NDIRI I G SI TVV I LLGIS V AGMEWE A KAQV IL LVI L L IG I 334
Cdd:TIGR00930 161 IGLIF A FANAV A VAMYVVGFAETV L DLL R E NG S k I MVDP I NDIRI Y G TV TVV V LLGIS F AGMEWE N KAQV LF LVI V L LS I 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 335 A N F F I GT V IP SNN e K KSR GFF NYQAS IF A ENF G P SFTEG EG - FFS V F A IFFP AA TGILAGANISGDL E DPQ D AIP R GT M L 413
Cdd:TIGR00930 241 L N I F V GT I IP AFD - K PAK GFF GLGNE IF S ENF I P GIPGP EG g FFS L F G IFFP SV TGILAGANISGDL K DPQ K AIP K GT L L 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 414 AI FI TTV A Y I G VAICVR ACVVRDATG SM NDT V V S gmn CNG SAAC glgyd FS R C Q H EP C Q YGLMNN F QVMS M VS G F G PLIT 493
Cdd:TIGR00930 320 AI LT TTV V Y L G SVVLFG ACVVRDATG DK NDT L V T --- NCT SAAC ----- FS E C A H NT C S YGLMNN L QVMS L VS P F P PLIT 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 494 AGIFSATLSSALASLVSAP KV FQALCKDNI FKG LQFF A KGYGKN N EPLR G Y F LT FV IA MA FILIAELN V IAPIISNFFLA 573
Cdd:TIGR00930 392 AGIFSATLSSALASLVSAP RL FQALCKDNI YPF LQFF G KGYGKN G EPLR A Y L LT AF IA EG FILIAELN T IAPIISNFFLA 471
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 574 SYALINFSCFHAS YAK SPGWRP AYGI Y NM W V SL F GA I LCCA V MF V I N WWAA VITY VI E LFLY I YVTYKKPDVNWGSSTQA 653
Cdd:TIGR00930 472 SYALINFSCFHAS LLR SPGWRP RFKY Y HW W L SL L GA S LCCA I MF L I S WWAA LVAM VI A LFLY K YVTYKKPDVNWGSSTQA 551
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 654 LSY VS AL DNA L E L TT VEDHVKN F RPQC I VLTG G P MT RPALLD ITHA FTK NS GL C IC CE V FV GPR KL CVKE MNSGM AK K Q A 733
Cdd:TIGR00930 552 LSY SL AL YSL L R L EE VEDHVKN W RPQC L VLTG P P VC RPALLD FASQ FTK GK GL M IC GS V IQ GPR LE CVKE AQAAE AK I Q T 631
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 734 WL M KNK I KAFYA A V A AD CF R D GVR S L L QASGLGRMKPNTLV I GYKK N WR K A PLSEL E N Y V GIIHDAFD FEIG VV I VR I S Q 813
Cdd:TIGR00930 632 WL E KNK V KAFYA V V V AD DL R E GVR H L I QASGLGRMKPNTLV M GYKK D WR Q A EPRAW E T Y I GIIHDAFD AHLA VV V VR N S E 711
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 814 G FD IS p VLQVQ D ELE kleqerlaleaaikd NDC E E gkggirglfkkagklnit KPAPKK D SN IST IQS MH vgefnqkl V E 893
Cdd:TIGR00930 712 G LP IS - VLQVQ E ELE --------------- NDC S E ------------------ DSIELN D GK IST QPD MH -------- L E 749
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 894 AS A QF K KKQGKGTIDVWWL F DDGGLTLL I PY I LT LR K K WK D CK L RI Y VG G - K IN R I E E EK IS MA S LL S KFRI KFAD I HII 972
Cdd:TIGR00930 750 AS T QF Q KKQGKGTIDVWWL V DDGGLTLL L PY L LT TK K V WK K CK I RI F VG A q K DD R S E Q EK KD MA T LL Y KFRI DAEV I VVL 829
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 973 G DIN I KP NK ES WKV FEEMI E P Y RLH ESH KD LTTAE - K LKRES PWKITDAEL EAVKE KSYRQVRLNELL Q E H SR A A N L I VL 1051
Cdd:TIGR00930 830 M DIN A KP QT ES MEA FEEMI R P F RLH KTE KD REAKD p K MTWTK PWKITDAEL QSNVR KSYRQVRLNELL L E Y SR D A A L V VL 909
970 980 990 1000
....*....|....*....|....*....|....*....|....
gi 1709297 1052 SLPV A RKGSI S D L LYMAWLE I L TKN LPPVLLVRGNH K NVLTFYS 1095
Cdd:TIGR00930 910 SLPV P RKGSI P D E LYMAWLE V L SED LPPVLLVRGNH R NVLTFYS 953
Name
Accession
Description
Interval
E-value
2a30
TIGR00930 K-Cl cotransporter; [Transport and binding proteins, Other]
100-1095
0e+00
K-Cl cotransporter; [Transport and binding proteins, Other]
Pssm-ID: 273347 [Multi-domain]
Cd Length: 953
Bit Score: 1540.43
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 100 NT M DAVP K IE Y YRN TGSVS GPK V NRPSL Q E I H EQ L A K N V AVAPGS AD RVA NG D GM PGD E Q AE N ---- KE EDVT G V VKFGW 175
Cdd:TIGR00930 1 NT V DAVP R IE H YRN SEGQG GPK R NRPSL E E L H DL L D K V V SLLGPL AD YTN NG Q GM KEH E E AE D aegt KE KPPA G A VKFGW 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 176 V K GVLV R C M LNIWGV M LF I RLSWIVG E AGIGL GVI II G L SVV VTT L TG I SMSAI C TNGVV R GGGAYYLISRSLGPEFGGS 255
Cdd:TIGR00930 81 V M GVLV P C L LNIWGV I LF L RLSWIVG Q AGIGL SLL II L L CCC VTT I TG L SMSAI A TNGVV K GGGAYYLISRSLGPEFGGS 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 256 IGLIF R FANAV R VAMYVVGFAETV V DLL K E SD S - M MVDP T NDIRI I G SI TVV I LLGIS V AGMEWE A KAQV IL LVI L L IG I 334
Cdd:TIGR00930 161 IGLIF A FANAV A VAMYVVGFAETV L DLL R E NG S k I MVDP I NDIRI Y G TV TVV V LLGIS F AGMEWE N KAQV LF LVI V L LS I 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 335 A N F F I GT V IP SNN e K KSR GFF NYQAS IF A ENF G P SFTEG EG - FFS V F A IFFP AA TGILAGANISGDL E DPQ D AIP R GT M L 413
Cdd:TIGR00930 241 L N I F V GT I IP AFD - K PAK GFF GLGNE IF S ENF I P GIPGP EG g FFS L F G IFFP SV TGILAGANISGDL K DPQ K AIP K GT L L 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 414 AI FI TTV A Y I G VAICVR ACVVRDATG SM NDT V V S gmn CNG SAAC glgyd FS R C Q H EP C Q YGLMNN F QVMS M VS G F G PLIT 493
Cdd:TIGR00930 320 AI LT TTV V Y L G SVVLFG ACVVRDATG DK NDT L V T --- NCT SAAC ----- FS E C A H NT C S YGLMNN L QVMS L VS P F P PLIT 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 494 AGIFSATLSSALASLVSAP KV FQALCKDNI FKG LQFF A KGYGKN N EPLR G Y F LT FV IA MA FILIAELN V IAPIISNFFLA 573
Cdd:TIGR00930 392 AGIFSATLSSALASLVSAP RL FQALCKDNI YPF LQFF G KGYGKN G EPLR A Y L LT AF IA EG FILIAELN T IAPIISNFFLA 471
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 574 SYALINFSCFHAS YAK SPGWRP AYGI Y NM W V SL F GA I LCCA V MF V I N WWAA VITY VI E LFLY I YVTYKKPDVNWGSSTQA 653
Cdd:TIGR00930 472 SYALINFSCFHAS LLR SPGWRP RFKY Y HW W L SL L GA S LCCA I MF L I S WWAA LVAM VI A LFLY K YVTYKKPDVNWGSSTQA 551
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 654 LSY VS AL DNA L E L TT VEDHVKN F RPQC I VLTG G P MT RPALLD ITHA FTK NS GL C IC CE V FV GPR KL CVKE MNSGM AK K Q A 733
Cdd:TIGR00930 552 LSY SL AL YSL L R L EE VEDHVKN W RPQC L VLTG P P VC RPALLD FASQ FTK GK GL M IC GS V IQ GPR LE CVKE AQAAE AK I Q T 631
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 734 WL M KNK I KAFYA A V A AD CF R D GVR S L L QASGLGRMKPNTLV I GYKK N WR K A PLSEL E N Y V GIIHDAFD FEIG VV I VR I S Q 813
Cdd:TIGR00930 632 WL E KNK V KAFYA V V V AD DL R E GVR H L I QASGLGRMKPNTLV M GYKK D WR Q A EPRAW E T Y I GIIHDAFD AHLA VV V VR N S E 711
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 814 G FD IS p VLQVQ D ELE kleqerlaleaaikd NDC E E gkggirglfkkagklnit KPAPKK D SN IST IQS MH vgefnqkl V E 893
Cdd:TIGR00930 712 G LP IS - VLQVQ E ELE --------------- NDC S E ------------------ DSIELN D GK IST QPD MH -------- L E 749
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 894 AS A QF K KKQGKGTIDVWWL F DDGGLTLL I PY I LT LR K K WK D CK L RI Y VG G - K IN R I E E EK IS MA S LL S KFRI KFAD I HII 972
Cdd:TIGR00930 750 AS T QF Q KKQGKGTIDVWWL V DDGGLTLL L PY L LT TK K V WK K CK I RI F VG A q K DD R S E Q EK KD MA T LL Y KFRI DAEV I VVL 829
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 973 G DIN I KP NK ES WKV FEEMI E P Y RLH ESH KD LTTAE - K LKRES PWKITDAEL EAVKE KSYRQVRLNELL Q E H SR A A N L I VL 1051
Cdd:TIGR00930 830 M DIN A KP QT ES MEA FEEMI R P F RLH KTE KD REAKD p K MTWTK PWKITDAEL QSNVR KSYRQVRLNELL L E Y SR D A A L V VL 909
970 980 990 1000
....*....|....*....|....*....|....*....|....
gi 1709297 1052 SLPV A RKGSI S D L LYMAWLE I L TKN LPPVLLVRGNH K NVLTFYS 1095
Cdd:TIGR00930 910 SLPV P RKGSI P D E LYMAWLE V L SED LPPVLLVRGNH R NVLTFYS 953
SLC12
pfam03522 Solute carrier family 12;
690-1095
0e+00
Solute carrier family 12;
Pssm-ID: 460955
Cd Length: 414
Bit Score: 605.38
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 690 RPAL L D IT H AF TKN SG L C IC CE V FV G PRKLCVKEMN sg MA K KQA WL M K N KIKAFYA A V AA D CF R D G VRS LLQASGLG RM K 769
Cdd:pfam03522 1 RPAL V D FA H LI TKN VS L M IC GH V VK G RLSQKLRSEL -- QK K AYR WL R K R KIKAFYA L V DG D NL R E G AQA LLQASGLG KL K 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 770 PN T L VI GYK KN WR KAPLS ELE N Y VGI IHDAFD FEIG V V I V R ISQ G F D I S PV LQ V QD EL E kleq ER L AL E AAIKDNDCEEG 849
Cdd:pfam03522 79 PN I L LM GYK SD WR TCDKE ELE E Y FNV IHDAFD LQYA V A I L R LPE G L D V S HL LQ D QD TE E ---- LG L GD E TNSSYAEQSSE 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 850 KGGIRGLFKKAG K LNI tkpa P KKDSN I S ------- TIQ S MHVGEFNQ KL V ------------------ EASA QF K KKQ G K 904
Cdd:pfam03522 155 EQSTSNSKQDDD K SKL ---- S KKDSN L S lspdkst KNP S GKDSSKSD KL K kkspsiilrtasnekeil NNIT QF Q KKQ K K 230
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 905 GTIDVWWL F DDGGLTLL I PYIL TL R K KW K DCKLR IYVG G - KINRI EEE KIS MASLLSKFRI KFA D IHI I G DI NI KP N KE S 983
Cdd:pfam03522 231 GTIDVWWL Y DDGGLTLL L PYIL ST R S KW S DCKLR VFAL G n RKDEL EEE QRN MASLLSKFRI DYS D LTV I P DI TK KP K KE T 310
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 984 W K V F E E M IEP Y RLHE SH K DL ttaeklkr ES PW KITD A ELEA V KEK SY RQ V RL N ELL Q EHS RA ANLIV LS LP VA RKG SI S D 1063
Cdd:pfam03522 311 K K F F D E L IEP F RLHE DD K EE -------- ES AE KITD S ELEA L KEK TN RQ L RL R ELL L EHS SD ANLIV MT LP MP RKG TV S A 382
410 420 430
....*....|....*....|....*....|..
gi 1709297 1064 L LYMAWLE I LTK N LPP V LLVRGN HKN VLTFYS 1095
Cdd:pfam03522 383 P LYMAWLE T LTK D LPP F LLVRGN QTS VLTFYS 414
PotE
COG0531 Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
217-645
2.34e-37
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
Pssm-ID: 440297 [Multi-domain]
Cd Length: 438
Bit Score: 146.58
E-value: 2.34e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 217 VVTT L TGI S MSAICTN g VV R G GGAY YLIS R S LGP EF G GSI G LIFRFANAVR VA MYV V G F AETVVD L L kesdsmmvd P TND 296
Cdd:COG0531 55 LLAL L VAL S YAELASA - FP R A GGAY TYAR R A LGP LL G FLA G WALLLSYVLA VA AVA V A F GGYLSS L F --------- P AGG 124
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 297 IRI I GSITVVI L LGISVA G MEWE AK AQV IL L V IL L IGIAN F FIG tvipsnnekksr G F F NYQASI F A e N F G P SFTEGE G F 376
Cdd:COG0531 125 SVL I ALVLILL L TLLNLR G VKES AK VNN IL T V LK L LVLLL F IVV ------------ G L F AFDPAN F T - P F L P AGGGLS G V 191
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 377 FSVF A IF F P A A TG IL A G AN ISGDLED P QDA IPR GTM L AIF I TT V A YI G V AIC vracvvrd A TG SMNDTVVSGMN cngsaa 456
Cdd:COG0531 192 LAAL A LA F F A F TG FE A I AN LAEEAKN P KRN IPR AII L SLL I VG V L YI L V SLA -------- L TG VVPYDELAASG ------ 257
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 457 cglgydfsrcqhepcqygl MNNFQVMSM V S G -- FGP LI TA G IFSAT L SSAL AS LVS A PKVFQ A LCK D NIF kg LQF FAK GY 534
Cdd:COG0531 258 ------------------- APLADAAEA V F G pw GAI LI AL G ALLSL L GALN AS ILG A SRLLY A MAR D GLL -- PKV FAK VH 316
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 535 GKNNE P LRGYF LT F VIA MAFI L I -- A ELNVI A PII S NFF L AS Y A L INFSCFHASY a KS P GWRPAYGIYNMWVSLF G AI LC 612
Cdd:COG0531 317 PRFGT P VNAIL LT G VIA LLLL L L ga A SFTAL A SLA S VGV L LA Y L L VALAVIVLRR - RR P DLPRPFRVPLPLIPIL G IL LC 395
410 420 430
....*....|....*....|....*....|....*.
gi 1709297 613 CAVMFVINWW A --- AVITYV I E L F LY IYVTYKK P DV 645
Cdd:COG0531 396 LFLLYLLGPG A lli GLVLLA I G L L LY LLYRRRH P KL 431
Name
Accession
Description
Interval
E-value
2a30
TIGR00930 K-Cl cotransporter; [Transport and binding proteins, Other]
100-1095
0e+00
K-Cl cotransporter; [Transport and binding proteins, Other]
Pssm-ID: 273347 [Multi-domain]
Cd Length: 953
Bit Score: 1540.43
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 100 NT M DAVP K IE Y YRN TGSVS GPK V NRPSL Q E I H EQ L A K N V AVAPGS AD RVA NG D GM PGD E Q AE N ---- KE EDVT G V VKFGW 175
Cdd:TIGR00930 1 NT V DAVP R IE H YRN SEGQG GPK R NRPSL E E L H DL L D K V V SLLGPL AD YTN NG Q GM KEH E E AE D aegt KE KPPA G A VKFGW 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 176 V K GVLV R C M LNIWGV M LF I RLSWIVG E AGIGL GVI II G L SVV VTT L TG I SMSAI C TNGVV R GGGAYYLISRSLGPEFGGS 255
Cdd:TIGR00930 81 V M GVLV P C L LNIWGV I LF L RLSWIVG Q AGIGL SLL II L L CCC VTT I TG L SMSAI A TNGVV K GGGAYYLISRSLGPEFGGS 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 256 IGLIF R FANAV R VAMYVVGFAETV V DLL K E SD S - M MVDP T NDIRI I G SI TVV I LLGIS V AGMEWE A KAQV IL LVI L L IG I 334
Cdd:TIGR00930 161 IGLIF A FANAV A VAMYVVGFAETV L DLL R E NG S k I MVDP I NDIRI Y G TV TVV V LLGIS F AGMEWE N KAQV LF LVI V L LS I 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 335 A N F F I GT V IP SNN e K KSR GFF NYQAS IF A ENF G P SFTEG EG - FFS V F A IFFP AA TGILAGANISGDL E DPQ D AIP R GT M L 413
Cdd:TIGR00930 241 L N I F V GT I IP AFD - K PAK GFF GLGNE IF S ENF I P GIPGP EG g FFS L F G IFFP SV TGILAGANISGDL K DPQ K AIP K GT L L 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 414 AI FI TTV A Y I G VAICVR ACVVRDATG SM NDT V V S gmn CNG SAAC glgyd FS R C Q H EP C Q YGLMNN F QVMS M VS G F G PLIT 493
Cdd:TIGR00930 320 AI LT TTV V Y L G SVVLFG ACVVRDATG DK NDT L V T --- NCT SAAC ----- FS E C A H NT C S YGLMNN L QVMS L VS P F P PLIT 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 494 AGIFSATLSSALASLVSAP KV FQALCKDNI FKG LQFF A KGYGKN N EPLR G Y F LT FV IA MA FILIAELN V IAPIISNFFLA 573
Cdd:TIGR00930 392 AGIFSATLSSALASLVSAP RL FQALCKDNI YPF LQFF G KGYGKN G EPLR A Y L LT AF IA EG FILIAELN T IAPIISNFFLA 471
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 574 SYALINFSCFHAS YAK SPGWRP AYGI Y NM W V SL F GA I LCCA V MF V I N WWAA VITY VI E LFLY I YVTYKKPDVNWGSSTQA 653
Cdd:TIGR00930 472 SYALINFSCFHAS LLR SPGWRP RFKY Y HW W L SL L GA S LCCA I MF L I S WWAA LVAM VI A LFLY K YVTYKKPDVNWGSSTQA 551
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 654 LSY VS AL DNA L E L TT VEDHVKN F RPQC I VLTG G P MT RPALLD ITHA FTK NS GL C IC CE V FV GPR KL CVKE MNSGM AK K Q A 733
Cdd:TIGR00930 552 LSY SL AL YSL L R L EE VEDHVKN W RPQC L VLTG P P VC RPALLD FASQ FTK GK GL M IC GS V IQ GPR LE CVKE AQAAE AK I Q T 631
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 734 WL M KNK I KAFYA A V A AD CF R D GVR S L L QASGLGRMKPNTLV I GYKK N WR K A PLSEL E N Y V GIIHDAFD FEIG VV I VR I S Q 813
Cdd:TIGR00930 632 WL E KNK V KAFYA V V V AD DL R E GVR H L I QASGLGRMKPNTLV M GYKK D WR Q A EPRAW E T Y I GIIHDAFD AHLA VV V VR N S E 711
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 814 G FD IS p VLQVQ D ELE kleqerlaleaaikd NDC E E gkggirglfkkagklnit KPAPKK D SN IST IQS MH vgefnqkl V E 893
Cdd:TIGR00930 712 G LP IS - VLQVQ E ELE --------------- NDC S E ------------------ DSIELN D GK IST QPD MH -------- L E 749
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 894 AS A QF K KKQGKGTIDVWWL F DDGGLTLL I PY I LT LR K K WK D CK L RI Y VG G - K IN R I E E EK IS MA S LL S KFRI KFAD I HII 972
Cdd:TIGR00930 750 AS T QF Q KKQGKGTIDVWWL V DDGGLTLL L PY L LT TK K V WK K CK I RI F VG A q K DD R S E Q EK KD MA T LL Y KFRI DAEV I VVL 829
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 973 G DIN I KP NK ES WKV FEEMI E P Y RLH ESH KD LTTAE - K LKRES PWKITDAEL EAVKE KSYRQVRLNELL Q E H SR A A N L I VL 1051
Cdd:TIGR00930 830 M DIN A KP QT ES MEA FEEMI R P F RLH KTE KD REAKD p K MTWTK PWKITDAEL QSNVR KSYRQVRLNELL L E Y SR D A A L V VL 909
970 980 990 1000
....*....|....*....|....*....|....*....|....
gi 1709297 1052 SLPV A RKGSI S D L LYMAWLE I L TKN LPPVLLVRGNH K NVLTFYS 1095
Cdd:TIGR00930 910 SLPV P RKGSI P D E LYMAWLE V L SED LPPVLLVRGNH R NVLTFYS 953
SLC12
pfam03522 Solute carrier family 12;
690-1095
0e+00
Solute carrier family 12;
Pssm-ID: 460955
Cd Length: 414
Bit Score: 605.38
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 690 RPAL L D IT H AF TKN SG L C IC CE V FV G PRKLCVKEMN sg MA K KQA WL M K N KIKAFYA A V AA D CF R D G VRS LLQASGLG RM K 769
Cdd:pfam03522 1 RPAL V D FA H LI TKN VS L M IC GH V VK G RLSQKLRSEL -- QK K AYR WL R K R KIKAFYA L V DG D NL R E G AQA LLQASGLG KL K 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 770 PN T L VI GYK KN WR KAPLS ELE N Y VGI IHDAFD FEIG V V I V R ISQ G F D I S PV LQ V QD EL E kleq ER L AL E AAIKDNDCEEG 849
Cdd:pfam03522 79 PN I L LM GYK SD WR TCDKE ELE E Y FNV IHDAFD LQYA V A I L R LPE G L D V S HL LQ D QD TE E ---- LG L GD E TNSSYAEQSSE 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 850 KGGIRGLFKKAG K LNI tkpa P KKDSN I S ------- TIQ S MHVGEFNQ KL V ------------------ EASA QF K KKQ G K 904
Cdd:pfam03522 155 EQSTSNSKQDDD K SKL ---- S KKDSN L S lspdkst KNP S GKDSSKSD KL K kkspsiilrtasnekeil NNIT QF Q KKQ K K 230
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 905 GTIDVWWL F DDGGLTLL I PYIL TL R K KW K DCKLR IYVG G - KINRI EEE KIS MASLLSKFRI KFA D IHI I G DI NI KP N KE S 983
Cdd:pfam03522 231 GTIDVWWL Y DDGGLTLL L PYIL ST R S KW S DCKLR VFAL G n RKDEL EEE QRN MASLLSKFRI DYS D LTV I P DI TK KP K KE T 310
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 984 W K V F E E M IEP Y RLHE SH K DL ttaeklkr ES PW KITD A ELEA V KEK SY RQ V RL N ELL Q EHS RA ANLIV LS LP VA RKG SI S D 1063
Cdd:pfam03522 311 K K F F D E L IEP F RLHE DD K EE -------- ES AE KITD S ELEA L KEK TN RQ L RL R ELL L EHS SD ANLIV MT LP MP RKG TV S A 382
410 420 430
....*....|....*....|....*....|..
gi 1709297 1064 L LYMAWLE I LTK N LPP V LLVRGN HKN VLTFYS 1095
Cdd:pfam03522 383 P LYMAWLE T LTK D LPP F LLVRGN QTS VLTFYS 414
AA_permease
pfam00324 Amino acid permease;
178-681
2.47e-124
Amino acid permease;
Pssm-ID: 366028 [Multi-domain]
Cd Length: 467
Bit Score: 388.99
E-value: 2.47e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 178 G V LVRCMLNIW G VM LF IRLSWIV G E AG IGLGVIIIGL S V VV TT L TGI S MSA I C TNG V V r G GG A Y YLI SR S LGP EF G GSI G 257
Cdd:pfam00324 1 H V QMIALGGVI G TG LF VGSGSVL G Q AG PAGALLGYLI S G VV IF L VML S LGE I S TNG P V - S GG F Y TYA SR F LGP SL G FAT G 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 258 L ------ I FRF A NAVRV A MYVVG F A E T V V D LLKES dsmmvdptndir II G SITV V I L LG I SVA G ME W EAK A QVILLV I LL 331
Cdd:pfam00324 80 W nywlsw I TVL A LELTA A SILIQ F W E L V P D IPYLW ------------ VW G AVFL V L L TI I NLV G VK W YGE A EFWFAL I KI 147
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 332 I G I AN F F I GTV I PSNNEKKSR G -- F FNYQASIFAE NF G P S F te G E GF F SVF A I F F P A A TGI LAGANIS G DLED P QDA IP R 409
Cdd:pfam00324 148 I A I IG F I I VGI I LLSGGNPND G ai F RYLGDNGGKN NF P P G F -- G K GF I SVF V I A F F A F TGI ELVGIAA G EVKN P EKS IP K 225
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 410 GTMLA I FIT T VA YI GVAICVRAC V VRDAT G SM ND TVVS gmncngsaacglgydfsrcqhepcq YGLMNN F QVMSMV SG FG 489
Cdd:pfam00324 226 AILQV I WRI T IF YI LSLLAIGLL V PWNDP G LL ND SASA ------------------------- ASPFVI F FKFLGI SG LA 280
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 490 PLI T A G I FS A T LS S A LA SL V S APKVFQA L CK D NIFK glq F F A K GYG K NNE PLR GYFLTF VI AMAFI L I A E LN vi AP I IS N 569
Cdd:pfam00324 281 PLI N A V I LT A A LS A A NS SL Y S GSRMLYS L AR D GLAP --- K F L K KVD K RGV PLR AILVSM VI SLLAL L L A S LN -- PA I VF N 355
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 570 F F LA SYA L INFSCFHASYAKSPGW R P A YGIYNMWVSLFGAILCCAVMF VI NWW AA V I TYV I EL FLY IYVTYKKPDV NWG S 649
Cdd:pfam00324 356 F L LA ISG L SGLIVWGLISLSHLRF R K A FKYQGRSIDELPFKAPLGPLG VI LGL AA I I IIL I IQ FLY AFLPVPGGPK NWG A 435
490 500 510
....*....|....*....|....*....|..
gi 1709297 650 STQ A LS Y VSA L DNALE L TT V ED HVKN FR PQ CI 681
Cdd:pfam00324 436 GSF A AA Y LIV L LFLII L IG V KL HVKN WK PQ LL 467
AA_permease_N
pfam08403 Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid ...
86-153
1.88e-37
Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid permease domain (pfam00324) in metazoan Na-K-Cl cotransporters.
Pssm-ID: 429977
Cd Length: 70
Bit Score: 134.49
E-value: 1.88e-37
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 86 D S H TN TYYLQTFGHNT M DAVP K I EY YRNTGSVSG P K VN RPSL Q E I H E QL A KN V -- AVA P GS A D R V A NGDG 153
Cdd:pfam08403 1 D T H GS TYYLQTFGHNT L DAVP R I DF YRNTGSVSG V K KS RPSL A E L H S QL K KN S al AVA E GS V D G V E NGDG 70
PotE
COG0531 Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
217-645
2.34e-37
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
Pssm-ID: 440297 [Multi-domain]
Cd Length: 438
Bit Score: 146.58
E-value: 2.34e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 217 VVTT L TGI S MSAICTN g VV R G GGAY YLIS R S LGP EF G GSI G LIFRFANAVR VA MYV V G F AETVVD L L kesdsmmvd P TND 296
Cdd:COG0531 55 LLAL L VAL S YAELASA - FP R A GGAY TYAR R A LGP LL G FLA G WALLLSYVLA VA AVA V A F GGYLSS L F --------- P AGG 124
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 297 IRI I GSITVVI L LGISVA G MEWE AK AQV IL L V IL L IGIAN F FIG tvipsnnekksr G F F NYQASI F A e N F G P SFTEGE G F 376
Cdd:COG0531 125 SVL I ALVLILL L TLLNLR G VKES AK VNN IL T V LK L LVLLL F IVV ------------ G L F AFDPAN F T - P F L P AGGGLS G V 191
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 377 FSVF A IF F P A A TG IL A G AN ISGDLED P QDA IPR GTM L AIF I TT V A YI G V AIC vracvvrd A TG SMNDTVVSGMN cngsaa 456
Cdd:COG0531 192 LAAL A LA F F A F TG FE A I AN LAEEAKN P KRN IPR AII L SLL I VG V L YI L V SLA -------- L TG VVPYDELAASG ------ 257
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 457 cglgydfsrcqhepcqygl MNNFQVMSM V S G -- FGP LI TA G IFSAT L SSAL AS LVS A PKVFQ A LCK D NIF kg LQF FAK GY 534
Cdd:COG0531 258 ------------------- APLADAAEA V F G pw GAI LI AL G ALLSL L GALN AS ILG A SRLLY A MAR D GLL -- PKV FAK VH 316
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 535 GKNNE P LRGYF LT F VIA MAFI L I -- A ELNVI A PII S NFF L AS Y A L INFSCFHASY a KS P GWRPAYGIYNMWVSLF G AI LC 612
Cdd:COG0531 317 PRFGT P VNAIL LT G VIA LLLL L L ga A SFTAL A SLA S VGV L LA Y L L VALAVIVLRR - RR P DLPRPFRVPLPLIPIL G IL LC 395
410 420 430
....*....|....*....|....*....|....*.
gi 1709297 613 CAVMFVINWW A --- AVITYV I E L F LY IYVTYKK P DV 645
Cdd:COG0531 396 LFLLYLLGPG A lli GLVLLA I G L L LY LLYRRRH P KL 431
AA_permease_2
pfam13520 Amino acid permease;
236-625
6.40e-16
Amino acid permease;
Pssm-ID: 404414 [Multi-domain]
Cd Length: 427
Bit Score: 81.59
E-value: 6.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 236 R G GG A Y YLISRSL G PEFGGSI G LIFR FA NAVRV A MYVVGF A ETVVDL L KES dsm M V DP T NDIRI I GSITVV I LLG I SVA G 315
Cdd:pfam13520 60 R S GG I Y VYLENAF G KFVAFLA G WSNW FA YVLGL A SSASVA A SYLLSA L GPD --- L V PT T WLTYG I AIAILI I FAI I NIR G 136
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 316 MEWE AK A Q V IL LVIL L IGIANFF I GTVIP snne KKSR G F FN Y q A S IFAEN F G P SFTE G eg F F SV F AIFFPAA TG ILAG AN 395
Cdd:pfam13520 137 VRES AK I Q N IL GILK L LLPLILI I ILGLV ---- TADG G G FN L - L S GEWHT F F P DGWP G -- V F AG F LGVLWSF TG FESA AN 209
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 396 I S G dl E DPQDAI P RGTMLAIF I TT V A YI G V A I CVRAC V VR D ATGSMNDTVVSG mncngsaacglgydfsrcqhepcqy G L 475
Cdd:pfam13520 210 V S E -- E VKKRNV P KAIFIGVI I VG V L YI L V N I AFFGV V PD D EIALSSGLGQVA ------------------------- A L 262
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709297 476 MNNFQVMSMVSGF gpl ITAGIFSAT L SSALASL V S A PKVFQ AL CK D NIFKGLQ FFAK g YG K NNE P L R GYF LT FVIAMAFI 555
Cdd:pfam13520 263 LFQAVGGKWGAII --- VVILLALSL L GAVNTAI V G A SRLLY AL AR D GVLPFSR FFAK - VN K FGS P I R AII LT AILSLILL 338
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1709297 556 L I ----- A EL N VIAPIISNFF L A SY A L INFSCFHASYAKSPGW R payg I YNM W VSLFGA IL CCAVMF V INWWAA V 625
Cdd:pfam13520 339 L L fllsp A AY N ALLSLSAYGY L L SY L L PIIGLLILRKKRPDLG R ---- I PGR W PVAIFG IL FSLFLI V ALFFPP V 409
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
