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Conserved domains on  [gi|1711570|sp|P52840|]
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RecName: Full=Sulfotransferase 1A1; Short=ST1A1; AltName: Full=Aryl sulfotransferase; AltName: Full=Phenol sulfotransferase; AltName: Full=Phenol/aryl sulfotransferase; Short=mSTp1; AltName: Full=ST1A4; AltName: Full=Sulfokinase

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
34-284 1.40e-102

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 300.03  E-value: 1.40e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1711570     34 PDDVLISTYPKSGTNWMSEIMDMIYQGGKLDKCGRAPV---YARIPFLEFSCP----GVPPGLETLKETPAPRIIKTHLP 106
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1711570    107 LSLLPQSLLDQKIKVIYVARNAKDVVVSYYNFYKMAKLHPDPGTWESFLENFMDGKVSYGSWYQHVKEWWELRRTHPVLY 186
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1711570    187 LFYEDMKENPKREIKKILEFLGRSLPEETVDLIVHHTSFKKMKENPMANYTTIPTEVmdhtiYPFMRKGTIGDWKNTFTV 266
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 1711570    267 AQSEHFDAHYAKLMTGCD 284
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
34-284 1.40e-102

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 300.03  E-value: 1.40e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1711570     34 PDDVLISTYPKSGTNWMSEIMDMIYQGGKLDKCGRAPV---YARIPFLEFSCP----GVPPGLETLKETPAPRIIKTHLP 106
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1711570    107 LSLLPQSLLDQKIKVIYVARNAKDVVVSYYNFYKMAKLHPDPGTWESFLENFMDGKVSYGSWYQHVKEWWELRRTHPVLY 186
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1711570    187 LFYEDMKENPKREIKKILEFLGRSLPEETVDLIVHHTSFKKMKENPMANYTTIPTEVmdhtiYPFMRKGTIGDWKNTFTV 266
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 1711570    267 AQSEHFDAHYAKLMTGCD 284
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 30-265 3.20e-20

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 88.82  E-value: 3.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1711570    30 FTAWPDDVLISTYPKSGTNWMSEIMDMIYQGGKLDKCGRaPVYAR-----IPFLEFSCPGVPPgLETLKETPAPrIIKTH 104
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSN-PLLKRnphefVPYIEIDFPFFPS-VDVLKDKGNT-LFSTH 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1711570   105 LPLSLLPQSLLDQKIKVIYVARNAKDVVVSYYNFYKMAKLHPDP-GTWESFLENFMDGKVSYGSWYQHVKEWWELRRTHP 183
Cdd:PLN02164 152 IPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGYWKAYQENP 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1711570   184 --VLYLFYEDMKENPKREIKKILEFLGRSLPEE-----TVDLIVHHTSFKKMKeNPMANYTTIPTEVMDhTIYP---FMR 253
Cdd:PLN02164 232 drILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSFETLK-NLEANKGEKDREDRP-AVYAnsaYFR 309

                        250
                 ....*....|..
gi 1711570   254 KGTIGDWKNTFT 265
Cdd:PLN02164 310 KGKVGDWQNYLT 321
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
118-242 6.05e-05

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 43.46  E-value: 6.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1711570  118 KIKVIYVARNakDVVVSYYNFYKMAKlhpdPGTWESF-LENF-MDGKVSY-----GSWYQHVKEW---WE--LRRT-HPV 184
Cdd:COG4424 103 DLKFIHLTRR--DKLAQAVSLVIAQQ----TGQWHSDaDDALaPTAPPEYdaeeiARLLEALQDFearWEawFARTgITP 176

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 1711570  185 LYLFYEDMKENPKREIKKILEFLGRSLPEETVDlivhhTSFKKMKENPMANYTTIPTE 242
Cdd:COG4424 177 LEITYEDLAADPVEVLNRVLDFLGVDPPLAPLR-----PALKKQADEPSDEWVARFRE 229
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
34-284 1.40e-102

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 300.03  E-value: 1.40e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1711570     34 PDDVLISTYPKSGTNWMSEIMDMIYQGGKLDKCGRAPV---YARIPFLEFSCP----GVPPGLETLKETPAPRIIKTHLP 106
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1711570    107 LSLLPQSLLDQKIKVIYVARNAKDVVVSYYNFYKMAKLHPDPGTWESFLENFMDGKVSYGSWYQHVKEWWELRRTHPVLY 186
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1711570    187 LFYEDMKENPKREIKKILEFLGRSLPEETVDLIVHHTSFKKMKENPMANYTTIPTEVmdhtiYPFMRKGTIGDWKNTFTV 266
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 1711570    267 AQSEHFDAHYAKLMTGCD 284
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 30-265 3.20e-20

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 88.82  E-value: 3.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1711570    30 FTAWPDDVLISTYPKSGTNWMSEIMDMIYQGGKLDKCGRaPVYAR-----IPFLEFSCPGVPPgLETLKETPAPrIIKTH 104
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSN-PLLKRnphefVPYIEIDFPFFPS-VDVLKDKGNT-LFSTH 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1711570   105 LPLSLLPQSLLDQKIKVIYVARNAKDVVVSYYNFYKMAKLHPDP-GTWESFLENFMDGKVSYGSWYQHVKEWWELRRTHP 183
Cdd:PLN02164 152 IPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGYWKAYQENP 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1711570   184 --VLYLFYEDMKENPKREIKKILEFLGRSLPEE-----TVDLIVHHTSFKKMKeNPMANYTTIPTEVMDhTIYP---FMR 253
Cdd:PLN02164 232 drILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSFETLK-NLEANKGEKDREDRP-AVYAnsaYFR 309

                        250
                 ....*....|..
gi 1711570   254 KGTIGDWKNTFT 265
Cdd:PLN02164 310 KGKVGDWQNYLT 321
Sulfotransfer_3 pfam13469
Sulfotransferase family;
120-213 6.33e-07

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 48.44  E-value: 6.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1711570    120 KVIYVARNAKDVVVSyyNFYKMAKLHPDPgtWESFLENFMDGKVSYgsWYQHVKEWWELRRTHP---VLYLFYEDMKENP 196
Cdd:pfam13469  83 KFIHLHRDPVDTVIS--SYCSLFGFTLSS--YSTAFLRDIGLALAR--WSRAYERLMAARARVPpgrFLDVRYEDLVADP 156

                          90
                  ....*....|....*..
gi 1711570    197 KREIKKILEFLGRSLPE 213
Cdd:pfam13469 157 EGTLRRILEFLGLPWDD 173
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
118-242 6.05e-05

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 43.46  E-value: 6.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1711570  118 KIKVIYVARNakDVVVSYYNFYKMAKlhpdPGTWESF-LENF-MDGKVSY-----GSWYQHVKEW---WE--LRRT-HPV 184
Cdd:COG4424 103 DLKFIHLTRR--DKLAQAVSLVIAQQ----TGQWHSDaDDALaPTAPPEYdaeeiARLLEALQDFearWEawFARTgITP 176

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 1711570  185 LYLFYEDMKENPKREIKKILEFLGRSLPEETVDlivhhTSFKKMKENPMANYTTIPTE 242
Cdd:COG4424 177 LEITYEDLAADPVEVLNRVLDFLGVDPPLAPLR-----PALKKQADEPSDEWVARFRE 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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