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Conserved domains on  [gi|550544292|sp|P47878|]
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RecName: Full=Insulin-like growth factor-binding protein 3; Short=IBP-3; Short=IGF-binding protein 3; Short=IGFBP-3; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 39-117 2.98e-24

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


:

Pssm-ID: 197525  Cd Length: 75  Bit Score: 93.30  E-value: 2.98e-24
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 550544292    39 RCEPCDAralSQCAPPPtaPACTELVREPGCGCCLTCALREGDACGVYTERCGTGLRCQPRPAEQYPLRALLNGRGFCA 117
Cdd:smart00121   2 RCPPCDP---ARCPPCP--PGCAELVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEERPLRALLHGQGVCM 75
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 214-286 1.06e-18

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


:

Pssm-ID: 459665  Cd Length: 66  Bit Score: 78.11  E-value: 1.06e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550544292  214 CRREMEDTLNHLKflNVLSPRGVHIPNCDKKGFYKKKQCRPSkgrkRGFCWCVDKYGQPLPGYDTKGKdDVHC 286
Cdd:pfam00086   1 CERERARALEQAA--SGRPASGLYIPNCDEDGFYKPVQCHGS----TGYCWCVDPEGQEIPGTRTRGG-DPDC 66
S15_NS1_EPRS_RNA-bind super family cl00349
S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, ...
 137-186 5.80e-03

S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, which can bind to several types of RNA. It is found in the ribosomal protein S15, the influenza A viral nonstructural protein (NSA) and in several eukaryotic aminoacyl tRNA synthetases (aaRSs), where it occurs as a single or a repeated unit. It is involved in both protein-RNA interactions by binding tRNA and protein-protein interactions in the formation of tRNA-synthetases into multienzyme complexes. While this domain lacks significant sequence similarity between the subgroups in which it is found, they share similar electrostatic surface potentials and thus are likely to bind to RNA via the same mechanism.


The actual alignment was detected with superfamily member CHL00027:

Pssm-ID: 469733  Cd Length: 90  Bit Score: 35.32  E-value: 5.80e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 550544292 137 NISESEEEHNAGSVESQVVPSTHRVtdsKFHPLHAKMdvikkgHARD--SQR 186
Cdd:CHL00027   9 VISQEEKEENRGSVEFQVFSFTNKI---RRLTSHLEL------HKKDysSQR 51
 
Name Accession Description Interval E-value
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 39-117 2.98e-24

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 93.30  E-value: 2.98e-24
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 550544292    39 RCEPCDAralSQCAPPPtaPACTELVREPGCGCCLTCALREGDACGVYTERCGTGLRCQPRPAEQYPLRALLNGRGFCA 117
Cdd:smart00121   2 RCPPCDP---ARCPPCP--PGCAELVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEERPLRALLHGQGVCM 75
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 214-286 1.06e-18

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 78.11  E-value: 1.06e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550544292  214 CRREMEDTLNHLKflNVLSPRGVHIPNCDKKGFYKKKQCRPSkgrkRGFCWCVDKYGQPLPGYDTKGKdDVHC 286
Cdd:pfam00086   1 CERERARALEQAA--SGRPASGLYIPNCDEDGFYKPVQCHGS----TGYCWCVDPEGQEIPGTRTRGG-DPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 213-282 1.72e-16

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 72.11  E-value: 1.72e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544292 213 PCRREMEDTLNHLKflnVLSPRGVHIPNCDKKGFYKKKQCRPSKgrkrGFCWCVDKYGQPLPGYDTKGKD 282
Cdd:cd00191    1 PCERERASALESLA---GPKLSGLYVPQCDEDGNYEPVQCHGST----GYCWCVDPDGEEIPGTRTRGGP 63
IGFBP pfam00219
Insulin-like growth factor binding protein;
41-96 2.68e-14

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 65.81  E-value: 2.68e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 550544292   41 EPCDAralSQCAPPPtaPACTELVREPGCGCCLTCALREGDACGVYTERCGTGLRC 96
Cdd:pfam00219   3 PPCDP---ERCPPPP--PGCPAGVVLDGCGCCKVCARQEGEPCGVYTPPCGKGLRC 53
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 238-288 4.76e-11

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 57.00  E-value: 4.76e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 550544292   238 IPNCDKKGFYKKKQCRPSkgrkRGFCWCVDKYGQPLPGYDTKGKDDvHCLS 288
Cdd:smart00211   1 IPQCDEDGNYEPVQCDGS----SGQCWCVDATGREIPGTRTEGGDP-DCPS 46
rps15 CHL00027
ribosomal protein S15
 137-186 5.80e-03

ribosomal protein S15


Pssm-ID: 214339  Cd Length: 90  Bit Score: 35.32  E-value: 5.80e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 550544292 137 NISESEEEHNAGSVESQVVPSTHRVtdsKFHPLHAKMdvikkgHARD--SQR 186
Cdd:CHL00027   9 VISQEEKEENRGSVEFQVFSFTNKI---RRLTSHLEL------HKKDysSQR 51
 
Name Accession Description Interval E-value
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 39-117 2.98e-24

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 93.30  E-value: 2.98e-24
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 550544292    39 RCEPCDAralSQCAPPPtaPACTELVREPGCGCCLTCALREGDACGVYTERCGTGLRCQPRPAEQYPLRALLNGRGFCA 117
Cdd:smart00121   2 RCPPCDP---ARCPPCP--PGCAELVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEERPLRALLHGQGVCM 75
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 214-286 1.06e-18

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 78.11  E-value: 1.06e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550544292  214 CRREMEDTLNHLKflNVLSPRGVHIPNCDKKGFYKKKQCRPSkgrkRGFCWCVDKYGQPLPGYDTKGKdDVHC 286
Cdd:pfam00086   1 CERERARALEQAA--SGRPASGLYIPNCDEDGFYKPVQCHGS----TGYCWCVDPEGQEIPGTRTRGG-DPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 213-282 1.72e-16

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 72.11  E-value: 1.72e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544292 213 PCRREMEDTLNHLKflnVLSPRGVHIPNCDKKGFYKKKQCRPSKgrkrGFCWCVDKYGQPLPGYDTKGKD 282
Cdd:cd00191    1 PCERERASALESLA---GPKLSGLYVPQCDEDGNYEPVQCHGST----GYCWCVDPDGEEIPGTRTRGGP 63
IGFBP pfam00219
Insulin-like growth factor binding protein;
41-96 2.68e-14

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 65.81  E-value: 2.68e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 550544292   41 EPCDAralSQCAPPPtaPACTELVREPGCGCCLTCALREGDACGVYTERCGTGLRC 96
Cdd:pfam00219   3 PPCDP---ERCPPPP--PGCPAGVVLDGCGCCKVCARQEGEPCGVYTPPCGKGLRC 53
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 238-288 4.76e-11

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 57.00  E-value: 4.76e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 550544292   238 IPNCDKKGFYKKKQCRPSkgrkRGFCWCVDKYGQPLPGYDTKGKDDvHCLS 288
Cdd:smart00211   1 IPQCDEDGNYEPVQCDGS----SGQCWCVDATGREIPGTRTEGGDP-DCPS 46
rps15 CHL00027
ribosomal protein S15
 137-186 5.80e-03

ribosomal protein S15


Pssm-ID: 214339  Cd Length: 90  Bit Score: 35.32  E-value: 5.80e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 550544292 137 NISESEEEHNAGSVESQVVPSTHRVtdsKFHPLHAKMdvikkgHARD--SQR 186
Cdd:CHL00027   9 VISQEEKEENRGSVEFQVFSFTNKI---RRLTSHLEL------HKKDysSQR 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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