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Conserved domains on  [gi|729087|sp|P40240|]
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RecName: Full=CD9 antigen; AltName: CD_antigen=CD9

Protein Classification

CD9 antigen( domain architecture ID 13626492)

CD9 antigen is a tetraspanin family protein that has a wide variety of biological activities such as cell adhesion, motility, metastasis, growth, signal transduction, differentiation, and sperm-egg fusion; tetraspanins are transmembrane (TM) glycoproteins with four TM segments that facilitate the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Symbol:  CD9
Gene Ontology:  GO:0005886
PubMed:  15763890|11756464|19709882|16024509|32231207|30356731|21428940
SCOP:  4001512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD9_LEL cd03152
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins ...
 109-191 3.85e-44

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD9 is found in virtually all tissues and is potentially involved in developmental processes. It associates with the tetraspanins CD81 and CD63, as well as with some integrin, and has been shown to be involved in a variety of activation, adhesion, and cell motility functions, as well as cell-cell interactions - such as during fertilization.


:

Pssm-ID: 239405  Cd Length: 84  Bit Score: 142.91  E-value: 3.85e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729087   109 YTHKDEVIKELQEFYKDTYQKLR-SKDEPQRETLKAIHMALDCCGIAGPLEQFISDTCPKKQLLESFQVKPCPEAISEVF 187
Cdd:cd03152   1 FSNKDKVVKEVQTFYRQTYAKYKqSRDPPLKETLKAIHFALDCCGPTGGLEQFVTDTCPKKEGLENLITKSCPDAIDDVF 80


                ....
gi 729087   188 NNKF 191
Cdd:cd03152  81 NSKL 84
Tetraspanin pfam00335
Tetraspanin family;
10-217 1.20e-39

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 134.75  E-value: 1.20e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729087      10 IKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQENNHSSFYtgvyILIGAGALMMLVGFLGCCGAVQESQCMLGL 89
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYIPI----LLIVLGAVIFLVGFLGCCGALKENRCLLLT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729087      90 FFGFLLVIFAIEIAAAVWGYTHKDEVIKELQEFYK----DTYQKLRSKDEPQRETLKAIHMALDCCGiagpleqfisdtc 165
Cdd:pfam00335  77 YFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKksleDGYRDWLDLYSCLNSALDSLQSEFGCCG------------- 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 729087     166 pkkqllesfqvkPCPEAISEVFNNKFHIIGAVGIGIAVVMIFGMIFSMILCC 217
Cdd:pfam00335 144 ------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
CD9_LEL cd03152
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins ...
 109-191 3.85e-44

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD9 is found in virtually all tissues and is potentially involved in developmental processes. It associates with the tetraspanins CD81 and CD63, as well as with some integrin, and has been shown to be involved in a variety of activation, adhesion, and cell motility functions, as well as cell-cell interactions - such as during fertilization.


Pssm-ID: 239405  Cd Length: 84  Bit Score: 142.91  E-value: 3.85e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729087   109 YTHKDEVIKELQEFYKDTYQKLR-SKDEPQRETLKAIHMALDCCGIAGPLEQFISDTCPKKQLLESFQVKPCPEAISEVF 187
Cdd:cd03152   1 FSNKDKVVKEVQTFYRQTYAKYKqSRDPPLKETLKAIHFALDCCGPTGGLEQFVTDTCPKKEGLENLITKSCPDAIDDVF 80


                ....
gi 729087   188 NNKF 191
Cdd:cd03152  81 NSKL 84
Tetraspanin pfam00335
Tetraspanin family;
10-217 1.20e-39

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 134.75  E-value: 1.20e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729087      10 IKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQENNHSSFYtgvyILIGAGALMMLVGFLGCCGAVQESQCMLGL 89
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYIPI----LLIVLGAVIFLVGFLGCCGALKENRCLLLT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729087      90 FFGFLLVIFAIEIAAAVWGYTHKDEVIKELQEFYK----DTYQKLRSKDEPQRETLKAIHMALDCCGiagpleqfisdtc 165
Cdd:pfam00335  77 YFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKksleDGYRDWLDLYSCLNSALDSLQSEFGCCG------------- 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 729087     166 pkkqllesfqvkPCPEAISEVFNNKFHIIGAVGIGIAVVMIFGMIFSMILCC 217
Cdd:pfam00335 144 ------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
CD9_LEL cd03152
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins ...
 109-191 3.85e-44

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD9 is found in virtually all tissues and is potentially involved in developmental processes. It associates with the tetraspanins CD81 and CD63, as well as with some integrin, and has been shown to be involved in a variety of activation, adhesion, and cell motility functions, as well as cell-cell interactions - such as during fertilization.


Pssm-ID: 239405  Cd Length: 84  Bit Score: 142.91  E-value: 3.85e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729087   109 YTHKDEVIKELQEFYKDTYQKLR-SKDEPQRETLKAIHMALDCCGIAGPLEQFISDTCPKKQLLESFQVKPCPEAISEVF 187
Cdd:cd03152   1 FSNKDKVVKEVQTFYRQTYAKYKqSRDPPLKETLKAIHFALDCCGPTGGLEQFVTDTCPKKEGLENLITKSCPDAIDDVF 80


                ....
gi 729087   188 NNKF 191
Cdd:cd03152  81 NSKL 84
Tetraspanin pfam00335
Tetraspanin family;
10-217 1.20e-39

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 134.75  E-value: 1.20e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729087      10 IKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQENNHSSFYtgvyILIGAGALMMLVGFLGCCGAVQESQCMLGL 89
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYIPI----LLIVLGAVIFLVGFLGCCGALKENRCLLLT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729087      90 FFGFLLVIFAIEIAAAVWGYTHKDEVIKELQEFYK----DTYQKLRSKDEPQRETLKAIHMALDCCGiagpleqfisdtc 165
Cdd:pfam00335  77 YFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKksleDGYRDWLDLYSCLNSALDSLQSEFGCCG------------- 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 729087     166 pkkqllesfqvkPCPEAISEVFNNKFHIIGAVGIGIAVVMIFGMIFSMILCC 217
Cdd:pfam00335 144 ------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
CD81_like_LEL cd03151
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. ...
 112-190 3.44e-13

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD81, also referred to as Target for anti-proliferative antigen-1, TAPA-1, is found in virtually all tissues, may be involved in regulation of cell growth and has been described as a member of the CD19/CD21/Leu-13 signal transduction complex identified on B cells (the B-Cell co-receptor).


Pssm-ID: 239404  Cd Length: 84  Bit Score: 62.82  E-value: 3.44e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729087   112 KDEVIKELQEFYKDTYQK-LRSKDEPQRETLKAIHMALDCCGiAGPLEQFIS----DTCPKKQLLESfqvKPCPEAISEV 186
Cdd:cd03151   4 KDQIIKEVQNFYDSAYQDaVTDTRSKGTAVLKTFHSTLDCCG-KGNLTALLSllstDLCPKKLLLDT---KDCHQEIDDL 79


                ....
gi 729087   187 FNNK 190
Cdd:cd03151  80 FSEK 83
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 109-190 6.27e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 43.26  E-value: 6.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729087   109 YTHKDEVIKELQEFYKDTYQKLRSKDEPQrETLKAIHMALDCCGIAGP-----LEQFISDTCPKKQLLESFQV---KPCP 180
Cdd:cd03127   1 FVYRDQLESLVSDTLNDAWDEYYVDDDFQ-EAMDALQSTFECCGVNGPtdyldLRLLVPSSCCKGTDGNCGLNlytEGCL 79

                        90
                ....*....|
gi 729087   181 EAISEVFNNK 190
Cdd:cd03127  80 EKLVDFLRSN 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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