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Conserved domains on  [gi|317373537|sp|P22061|]
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RecName: Full=Protein-L-isoaspartate(D-aspartate) O-methyltransferase; Short=PIMT; AltName: Full=L-isoaspartyl protein carboxyl methyltransferase; AltName: Full=Protein L-isoaspartyl/D-aspartyl methyltransferase; AltName: Full=Protein-beta-aspartate methyltransferase

Protein Classification

protein-L-isoaspartate O-methyltransferase( domain architecture ID 12014395)

protein-L-isoaspartate O-methyltransferase catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
8-216 3.18e-113

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


:

Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 322.40  E-value: 3.18e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537    8 ASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKC----NPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKAL 83
Cdd:pfam01135   1 NRNEALIENLKNYGVIKSDKVAEAMLAVDREEFVPEsfksYAYEDIPLSIGYGQTISAPHMHAMMLELL--ELKPGMRVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537   84 DVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKDDPTllssgRVQLVVGDGRMGYAEEAPYDAIHVGAAAP 163
Cdd:pfam01135  79 EIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGLE-----NVIVVVGDGRQGWPEFAPYDAIHVGAAAP 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 317373537  164 VVPQALIDQLKPGGRLILPVGPaGGNQMLEQYDKLQDGSIKMKPLMGVIYVPL 216
Cdd:pfam01135 154 EIPEALIDQLKEGGRLVIPVGP-NGNQVLQQFDKRNDGSVVIKDLEGVRFVPL 205
 
Name Accession Description Interval E-value
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
8-216 3.18e-113

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 322.40  E-value: 3.18e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537    8 ASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKC----NPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKAL 83
Cdd:pfam01135   1 NRNEALIENLKNYGVIKSDKVAEAMLAVDREEFVPEsfksYAYEDIPLSIGYGQTISAPHMHAMMLELL--ELKPGMRVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537   84 DVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKDDPTllssgRVQLVVGDGRMGYAEEAPYDAIHVGAAAP 163
Cdd:pfam01135  79 EIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGLE-----NVIVVVGDGRQGWPEFAPYDAIHVGAAAP 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 317373537  164 VVPQALIDQLKPGGRLILPVGPaGGNQMLEQYDKLQDGSIKMKPLMGVIYVPL 216
Cdd:pfam01135 154 EIPEALIDQLKEGGRLVIPVGP-NGNQVLQQFDKRNDGSVVIKDLEGVRFVPL 205
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 4-223 6.46e-74

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 223.16  E-value: 6.46e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537    4 KSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYA----KCNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEG 79
Cdd:TIGR00080   1 MDLESQKKALIDKLINEGYIKSKRVIDALLSVPREEFVpehfKEYAYVDTPLEIGYGQTISAPHMVAMMTELL--ELKPG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537   80 AKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKddptlLSSGRVQLVVGDGRMGYAEEAPYDAIHVG 159
Cdd:TIGR00080  79 MKVLEIGTGSGYQAAVLAEIVGRDGLVVSIERIPELAEKAERRLRK-----LGLDNVIVIVGDGTQGWEPLAPYDRIYVT 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 317373537  160 AAAPVVPQALIDQLKPGGRLILPVGPagGNQMLEQYDKlQDGSIKMKPLMGVIYVPLTDKEKQW 223
Cdd:TIGR00080 154 AAGPKIPEALIDQLKEGGILVMPVGE--YLQVLKRAEK-RGGEIIIKDVEPVAFVPLVGGEGFQ 214
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 12-220 2.10e-54

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 173.28  E-value: 2.10e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  12 ELIHNLRKNGIIKTDKVFEVMLATDR----SHYAKCNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGS 87
Cdd:PRK13942   8 RVIEELIREGYIKSKKVIDALLKVPRhlfvPEYLEEYAYVDTPLEIGYGQTISAIHMVAIMCELL--DLKEGMKVLEIGT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  88 GSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKddptlLSSGRVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQ 167
Cdd:PRK13942  86 GSGYHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKK-----LGYDNVEVIVGDGTLGYEENAPYDRIYVTAAGPDIPK 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 317373537 168 ALIDQLKPGGRLILPVGPAggNQMLEQYDKlQDGSIKMKPLMGVIYVPLTDKE 220
Cdd:PRK13942 161 PLIEQLKDGGIMVIPVGSY--SQELIRVEK-DNGKIIKKKLGEVAFVPLIGKN 210
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 17-217 2.81e-54

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 172.58  E-value: 2.81e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  17 LRKNGIiKTDKVFEVMLATDR--------SHYAkcnpYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGSG 88
Cdd:COG2518    4 LRPRGV-TDPRVLDAMRAVPRelfvpealRELA----YADRALPIGHGQTISQPYIVARMLEAL--DLKPGDRVLEIGTG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  89 SGILTACFARMVGctgKVIGIDHIKELVDDSVNNVRKddptlLSSGRVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQA 168
Cdd:COG2518   77 SGYQAAVLARLAG---RVYSVERDPELAERARERLAA-----LGYDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEA 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 317373537 169 LIDQLKPGGRLILPVGPaGGNQMLEQYDKLQDGsIKMKPLMGVIYVPLT 217
Cdd:COG2518  149 LLEQLAPGGRLVAPVGE-GGVQRLVLITRTGDG-FERESLFEVRFVPLR 195
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 81-183 8.06e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 48.97  E-value: 8.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  81 KALDVGSGSGILTACFARMVGCtgKVIGIDhikelVDDSVNNVRKDDPTLLSSGRVQLVVGDGRMG-YAEEAPYDAIHVG 159
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGA--RVTGVD-----ISPVALELARKAAAALLADNVEVLKGDAEELpPEADESFDVIISD 73

                         90       100       110
                 ....*....|....*....|....*....|.
gi 317373537 160 AAAPVV---PQALIDQ----LKPGGRLILPV 183
Cdd:cd02440   74 PPLHHLvedLARFLEEarrlLKPGGVLVLTL 104
 
Name Accession Description Interval E-value
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
8-216 3.18e-113

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 322.40  E-value: 3.18e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537    8 ASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKC----NPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKAL 83
Cdd:pfam01135   1 NRNEALIENLKNYGVIKSDKVAEAMLAVDREEFVPEsfksYAYEDIPLSIGYGQTISAPHMHAMMLELL--ELKPGMRVL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537   84 DVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKDDPTllssgRVQLVVGDGRMGYAEEAPYDAIHVGAAAP 163
Cdd:pfam01135  79 EIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGLE-----NVIVVVGDGRQGWPEFAPYDAIHVGAAAP 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 317373537  164 VVPQALIDQLKPGGRLILPVGPaGGNQMLEQYDKLQDGSIKMKPLMGVIYVPL 216
Cdd:pfam01135 154 EIPEALIDQLKEGGRLVIPVGP-NGNQVLQQFDKRNDGSVVIKDLEGVRFVPL 205
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 4-223 6.46e-74

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 223.16  E-value: 6.46e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537    4 KSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYA----KCNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEG 79
Cdd:TIGR00080   1 MDLESQKKALIDKLINEGYIKSKRVIDALLSVPREEFVpehfKEYAYVDTPLEIGYGQTISAPHMVAMMTELL--ELKPG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537   80 AKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKddptlLSSGRVQLVVGDGRMGYAEEAPYDAIHVG 159
Cdd:TIGR00080  79 MKVLEIGTGSGYQAAVLAEIVGRDGLVVSIERIPELAEKAERRLRK-----LGLDNVIVIVGDGTQGWEPLAPYDRIYVT 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 317373537  160 AAAPVVPQALIDQLKPGGRLILPVGPagGNQMLEQYDKlQDGSIKMKPLMGVIYVPLTDKEKQW 223
Cdd:TIGR00080 154 AAGPKIPEALIDQLKEGGILVMPVGE--YLQVLKRAEK-RGGEIIIKDVEPVAFVPLVGGEGFQ 214
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 12-220 2.10e-54

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 173.28  E-value: 2.10e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  12 ELIHNLRKNGIIKTDKVFEVMLATDR----SHYAKCNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGS 87
Cdd:PRK13942   8 RVIEELIREGYIKSKKVIDALLKVPRhlfvPEYLEEYAYVDTPLEIGYGQTISAIHMVAIMCELL--DLKEGMKVLEIGT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  88 GSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKddptlLSSGRVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQ 167
Cdd:PRK13942  86 GSGYHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKK-----LGYDNVEVIVGDGTLGYEENAPYDRIYVTAAGPDIPK 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 317373537 168 ALIDQLKPGGRLILPVGPAggNQMLEQYDKlQDGSIKMKPLMGVIYVPLTDKE 220
Cdd:PRK13942 161 PLIEQLKDGGIMVIPVGSY--SQELIRVEK-DNGKIIKKKLGEVAFVPLIGKN 210
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 17-217 2.81e-54

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 172.58  E-value: 2.81e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  17 LRKNGIiKTDKVFEVMLATDR--------SHYAkcnpYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGSG 88
Cdd:COG2518    4 LRPRGV-TDPRVLDAMRAVPRelfvpealRELA----YADRALPIGHGQTISQPYIVARMLEAL--DLKPGDRVLEIGTG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  89 SGILTACFARMVGctgKVIGIDHIKELVDDSVNNVRKddptlLSSGRVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQA 168
Cdd:COG2518   77 SGYQAAVLARLAG---RVYSVERDPELAERARERLAA-----LGYDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEVPEA 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 317373537 169 LIDQLKPGGRLILPVGPaGGNQMLEQYDKLQDGsIKMKPLMGVIYVPLT 217
Cdd:COG2518  149 LLEQLAPGGRLVAPVGE-GGVQRLVLITRTGDG-FERESLFEVRFVPLR 195
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
13-220 7.01e-47

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 154.21  E-value: 7.01e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  13 LIHNLRKNGIiKTDKVFEVMLATDRS--------HYAkcnpYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALD 84
Cdd:PRK00312  12 LVLRLRAEGI-LDERVLEAIEATPRElfvpeafkHKA----YENRALPIGCGQTISQPYMVARMTELL--ELKPGDRVLE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  85 VGSGSGILTACFARMVGctgKVIGIDHIKELVDDSVNNVRKddptlLSSGRVQLVVGDGRMGYAEEAPYDAIHVGAAAPV 164
Cdd:PRK00312  85 IGTGSGYQAAVLAHLVR---RVFSVERIKTLQWEAKRRLKQ-----LGLHNVSVRHGDGWKGWPAYAPFDRILVTAAAPE 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 317373537 165 VPQALIDQLKPGGRLILPVGpaGGNQMLEQYDKLQDGSIKMKPLMGVIYVPLTDKE 220
Cdd:PRK00312 157 IPRALLEQLKEGGILVAPVG--GEEQQLLTRVRKRGGRFEREVLEEVRFVPLVKGE 210
PRK13944 PRK13944
protein-L-isoaspartate O-methyltransferase; Provisional
 13-216 4.46e-34

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 140001  Cd Length: 205  Bit Score: 121.07  E-value: 4.46e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  13 LIHNLRKNGIIKTDKVFEVMLATDRSHYA----KCNPYMDSPQSIGFQATISAPHMHAYALELLfdQLHEGAKALDVGSG 88
Cdd:PRK13944   5 LVEELVREGIIKSERVKKAMLSVPREEFVmpeyRMMAYEDRPLPLFAGATISAPHMVAMMCELI--EPRPGMKILEVGTG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  89 SGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKddptLLSSGRVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQA 168
Cdd:PRK13944  83 SGYQAAVCAEAIERRGKVYTVEIVKELAIYAAQNIER----LGYWGVVEVYHGDGKRGLEKHAPFDAIIVTAAASTIPSA 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 317373537 169 LIDQLKPGGRLILPVGPAGGnQMLEQYDKLQDGsIKMKPLMGVIYVPL 216
Cdd:PRK13944 159 LVRQLKDGGVLVIPVEEGVG-QVLYKVVKRGEK-VEKRAITYVLFVPL 204
methyltran_FxLD TIGR04364
methyltransferase, FxLD system; Members of this family resemble occur regularly in the ...
 11-183 8.52e-21

methyltransferase, FxLD system; Members of this family resemble occur regularly in the vicinity of lantibiotic biosynthesis enzymes and their probable target, the FxLD family of putative ribosomal natural product precursor (TIGR04363). Members resemble protein-L-isoaspartate O-methyltransferase (TIGR00080) and a predicted methyltranserase, TIGR04188, of another putative peptide modification system.


Pssm-ID: 275158  Cd Length: 394  Bit Score: 89.35  E-value: 8.52e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537   11 SELIHNLRKNGIIKTDKVFEVMLATDRSHYAKCNP----YM----------DSPQSIgfqATISAPHMHAYALELLfdQL 76
Cdd:TIGR04364   6 AALVDELREDGVIRSPRVEAAFRTVPRHLFAPGAPlekaYAanravvtkrdEDGRAL---SSVSAPHIQAMMLEQA--GV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537   77 HEGAKALDVGSGsGILTACFARMVGCTGKVIGIDHIKELVDDSvnnvRKddptLLSS---GRVQLVVGDGRMGYAEEAPY 153
Cdd:TIGR04364  81 EPGMRVLEIGSG-GYNAALLAELVGPSGEVTTVDIDEDVTDRA----RA----CLAAagyPQVTVVLADAEAGVPELAPY 151

                         170       180       190
                  ....*....|....*....|....*....|
gi 317373537  154 DAIHVGAAAPVVPQALIDQLKPGGRLILPV 183
Cdd:TIGR04364 152 DRIIVTVGAWDIPPAWLDQLAPGGRLVVPL 181
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 6-183 2.01e-19

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 84.90  E-value: 2.01e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537   6 GGASHSELIHNLRKNGIikTDKVFEVMLATDRS-----HYAKCNPYMD----SPQSIGFQATISAPHMHAYALELLfdQL 76
Cdd:PRK13943   3 EFFMREKLFWILKKYGI--SDHIAKAFLEVPREefltkSYPLSYVYEDivlvSYDDGEEYSTSSQPSLMALFMEWV--GL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  77 HEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKddptlLSSGRVQLVVGDGRMGYAEEAPYDAI 156
Cdd:PRK13943  79 DKGMRVLEIGGGTGYNAAVMSRVVGEKGLVVSVEYSRKICEIAKRNVRR-----LGIENVIFVCGDGYYGVPEFAPYDVI 153

                        170       180
                 ....*....|....*....|....*..
gi 317373537 157 HVGAAAPVVPQALIDQLKPGGRLILPV 183
Cdd:PRK13943 154 FVTVGVDEVPETWFTQLKEGGRVIVPI 180
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 76-180 1.20e-11

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 62.10  E-value: 1.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  76 LHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKddptLLSSGRVQLVVGDGRMGYAEEaPYDA 155
Cdd:COG2519   89 IFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLER----FGLPDNVELKLGDIREGIDEG-DVDA 163

                         90       100
                 ....*....|....*....|....*..
gi 317373537 156 IHVGAAAP--VVPQAlIDQLKPGGRLI 180
Cdd:COG2519  164 VFLDMPDPweALEAV-AKALKPGGVLV 189
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 70-181 1.89e-10

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 56.56  E-value: 1.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  70 ELLFDQLHEGAKALDVGSGSGILTACFARMvGCtgKVIGIDhikeLVDDSVNNVRKddptLLSSGRVQLVVGDGRMGYAE 149
Cdd:COG2227   16 ALLARLLPAGGRVLDVGCGTGRLALALARR-GA--DVTGVD----ISPEALEIARE----RAAELNVDFVQGDLEDLPLE 84

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 317373537 150 EAPYDAI-------HVGAAAPVVpQALIDQLKPGGRLIL 181
Cdd:COG2227   85 DGSFDLVicsevleHLPDPAALL-RELARLLKPGGLLLL 122
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 68-181 4.60e-10

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 56.48  E-value: 4.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  68 ALELLFD--QLHEGAKALDVGSGSGILTACFARMVGCtgKVIGIDhikeLVDDSVNNVRKDDPTLLSSGRVQLVVGDGRm 145
Cdd:COG2230   39 KLDLILRklGLKPGMRVLDIGCGWGGLALYLARRYGV--RVTGVT----LSPEQLEYARERAAEAGLADRVEVRLADYR- 111

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 317373537 146 GYAEEAPYDAI-------HVGAAA-PVVPQALIDQLKPGGRLIL 181
Cdd:COG2230  112 DLPADGQFDAIvsigmfeHVGPENyPAYFAKVARLLKPGGRLLL 155
methyltr_grsp TIGR04188
methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are ...
 76-188 5.45e-10

methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).


Pssm-ID: 275041  Cd Length: 363  Bit Score: 58.14  E-value: 5.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537   76 LHEGAKALDVGSGSGILTACFARMVGcTGKVIGIDhikelVDDSVnnVRKDDPTLLSSG-RVQLVVGDGRMGYAEEAPYD 154
Cdd:TIGR04188 105 VEDGHRVLEIGTGTGYSAALLCHRLG-DDNVTSVE-----VDPGL--AARAASALAAAGyAPTVVTGDGLLGHPPRAPYD 176

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 317373537  155 AIHVGAAAPVVPQALIDQLKPGGRLILPVG---PAGG 188
Cdd:TIGR04188 177 RIIATCAVRRVPPAWLRQTRPGGVILTTLSgwlYGGG 213
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
69-181 1.66e-09

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 56.33  E-value: 1.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  69 LELLFDQLHEGAKALDVGSGSGILtACFARMVGCtGKVIGIDhikelVDD-SV---------NNVrkddptllsSGRVQL 138
Cdd:COG2264  139 LEALEKLLKPGKTVLDVGCGSGIL-AIAAAKLGA-KRVLAVD-----IDPvAVeaarenaelNGV---------EDRIEV 202

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 317373537 139 VVGDGRmgyaEEAPYDAIhVgA---AAPVVPQA--LIDQLKPGGRLIL 181
Cdd:COG2264  203 VLGDLL----EDGPYDLV-V-AnilANPLIELApdLAALLKPGGYLIL 244
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
78-181 1.93e-09

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 53.29  E-value: 1.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  78 EGAKALDVGSGSGILTACFARMVGCtGKVIGIDhikeLVDDSVNNVRKDDPtllssgRVQLVVGDGRmGYAEEAPYDAIH 157
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERFPG-ARVTGVD----LSPEMLARARARLP------NVRFVVADLR-DLDPPEPFDLVV 68

                         90       100       110
                 ....*....|....*....|....*....|
gi 317373537 158 VGAA------APVVPQALIDQLKPGGRLIL 181
Cdd:COG4106   69 SNAAlhwlpdHAALLARLAAALAPGGVLAV 98
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 83-177 3.01e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 52.57  E-value: 3.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537   83 LDVGSGSGILTACFARMVGCtgKVIGIDHIKELVDDSVNNVRKDDPtllssgRVQLVVGDGRMGYAEEAPYDAIHVGAAA 162
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGGA--RVTGVDLSPEMLERARERAAEAGL------NVEFVQGDAEDLPFPDGSFDLVVSSGVL 73

                          90       100
                  ....*....|....*....|...
gi 317373537  163 PVVPQALIDQ--------LKPGG 177
Cdd:pfam13649  74 HHLPDPDLEAalreiarvLKPGG 96
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 68-211 6.95e-09

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 53.77  E-value: 6.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  68 ALELLFDQLHEGAKALDVGSGSGILTACFARMVGctGKVIGIDHIKELVDDSVNNVRKddptlLSSGRVQLVVGD-GRMG 146
Cdd:COG0500   16 ALLALLERLPKGGRVLDLGCGTGRNLLALAARFG--GRVIGIDLSPEAIALARARAAK-----AGLGNVEFLVADlAELD 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 317373537 147 YAEEAPYDAI-------HVgaaAPVVPQALID----QLKPGGRLILPVGPAGGNQMLEQYDKLQDGSIKMKPLMGV 211
Cdd:COG0500   89 PLPAESFDLVvafgvlhHL---PPEEREALLRelarALKPGGVLLLSASDAAAALSLARLLLLATASLLELLLLLR 161
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 65-181 7.50e-09

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 52.69  E-value: 7.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  65 HAYALELLfdQLHEGAKALDVGSGSGILTACFARMvgcTGKVIGIDHIKELVDDSVNNVRKDDPtllssgRVQLVVGDG- 143
Cdd:COG2226   11 REALLAAL--GLRPGARVLDLGCGTGRLALALAER---GARVTGVDISPEMLELARERAAEAGL------NVEFVVGDAe 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 317373537 144 RMGYAEEApYDAIHVGAAAPVVP--QALIDQ----LKPGGRLIL 181
Cdd:COG2226   80 DLPFPDGS-FDLVISSFVLHHLPdpERALAEiarvLKPGGRLVV 122
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 81-183 8.06e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 48.97  E-value: 8.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  81 KALDVGSGSGILTACFARMVGCtgKVIGIDhikelVDDSVNNVRKDDPTLLSSGRVQLVVGDGRMG-YAEEAPYDAIHVG 159
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGA--RVTGVD-----ISPVALELARKAAAALLADNVEVLKGDAEELpPEADESFDVIISD 73

                         90       100       110
                 ....*....|....*....|....*....|.
gi 317373537 160 AAAPVV---PQALIDQ----LKPGGRLILPV 183
Cdd:cd02440   74 PPLHHLvedLARFLEEarrlLKPGGVLVLTL 104
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 59-183 3.48e-07

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 47.71  E-value: 3.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537   59 ISAPHMHAYALELLfdQLHEGAKALDVGSGSGILTACFARMVGcTGKVIGIDHIKELVDDSVNNVRKddptlLSSGRVQL 138
Cdd:TIGR02469   2 MTKREVRALTLAKL--RLRPGDVLWDIGAGTGSVTIEAARLVP-NGRVYAIERNPEALDLIERNLRR-----FGVSNIVI 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 317373537  139 VVGDgrmgyAEEAPY------DAIHVGAAA---PVVPQALIDQLKPGGRLILPV 183
Cdd:TIGR02469  74 VEGD-----APEAPEallpdpDAVFVGGSGgllQEILEAVERRLRPGGRIVLNA 122
PRK08317 PRK08317
hypothetical protein; Provisional
 66-181 5.05e-07

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 48.78  E-value: 5.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  66 AYALELLfdQLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVdDSVNNVRKDDptllsSGRVQLVVGDG-R 144
Cdd:PRK08317   9 ARTFELL--AVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAML-ALAKERAAGL-----GPNVEFVRGDAdG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 317373537 145 MGYAEEApYDAI-------HVGAaapvvPQALIDQ----LKPGGRLIL 181
Cdd:PRK08317  81 LPFPDGS-FDAVrsdrvlqHLED-----PARALAEiarvLRPGGRVVV 122
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 79-181 6.90e-07

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 48.61  E-value: 6.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  79 GAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDdsvnNVRKDDPTLLSSGRVQLVVGDgrmgyAEEAPY----- 153
Cdd:PRK00216  52 GDKVLDLACGTGDLAIALAKAVGKTGEVVGLDFSEGMLA----VGREKLRDLGLSGNVEFVQGD-----AEALPFpdnsf 122

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 317373537 154 DAIHVGAAAPVVPQalIDQ--------LKPGGRL-IL 181
Cdd:PRK00216 123 DAVTIAFGLRNVPD--IDKalremyrvLKPGGRLvIL 157
arsM PRK11873
arsenite methyltransferase;
73-125 2.31e-06

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 47.25  E-value: 2.31e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 317373537  73 FDQLHEGAKALDVGSGSGIltACF--ARMVGCTGKVIGIDHIKELVDDSVNNVRK 125
Cdd:PRK11873  72 LAELKPGETVLDLGSGGGF--DCFlaARRVGPTGKVIGVDMTPEMLAKARANARK 124
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 76-181 2.35e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 45.87  E-value: 2.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537   76 LHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKddptlLSSGRVQLVVGDgrmgyAEEAP--- 152
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENAQK-----LGFDNVEFEQGD-----IEELPell 70

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 317373537  153 ----YD------AIHVGAAAPVVPQALIDQLKPGGRLIL 181
Cdd:pfam13847  71 eddkFDvvisncVLNHIPDPDKVLQEILRVLKPGGRLII 109
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
69-181 1.11e-05

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 45.14  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  69 LELLFDQLHEGAKALDVGSGSGILtACFARMVGCTgKVIGIDhIKEL-VDDSVNNVRkddptlLSSGRVQLVVGDGrmgy 147
Cdd:PRK00517 110 LEALEKLVLPGKTVLDVGCGSGIL-AIAAAKLGAK-KVLAVD-IDPQaVEAARENAE------LNGVELNVYLPQG---- 176

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 317373537 148 aeEAPYDAIhVgA---AAPVVpqALIDQ----LKPGGRLIL 181
Cdd:PRK00517 177 --DLKADVI-V-AnilANPLL--ELAPDlarlLKPGGRLIL 211
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 83-181 1.20e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 42.65  E-value: 1.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537   83 LDVGSGSGILTACFARMVgctGKVIGIDHIKELVDDSVNNVRKDDptllssgrVQLVVGDG-RMGYAEEApYDAIHVGAA 161
Cdd:pfam08241   1 LDVGCGTGLLTELLARLG---ARVTGVDISPEMLELAREKAPREG--------LTFVVGDAeDLPFPDNS-FDLVLSSEV 68

                          90       100
                  ....*....|....*....|....*.
gi 317373537  162 A---PVVPQAL--IDQ-LKPGGRLIL 181
Cdd:pfam08241  69 LhhvEDPERALreIARvLKPGGILII 94
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 68-183 1.75e-05

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 44.02  E-value: 1.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  68 ALELLFDQLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKddptLLSSGRVQLVVGDGRMGY 147
Cdd:PRK00377  30 ALALSKLRLRKGDMILDIGCGTGSVTVEASLLVGETGKVYAVDKDEKAINLTRRNAEK----FGVLNNIVLIKGEAPEIL 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 317373537 148 AEEAP-YDAIHVGAAA---PVVPQALIDQLKPGGRLILPV 183
Cdd:PRK00377 106 FTINEkFDRIFIGGGSeklKEIISASWEIIKKGGRIVIDA 145
PRK14968 PRK14968
putative methyltransferase; Provisional
 70-110 5.30e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 42.58  E-value: 5.30e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 317373537  70 ELLFDQLHE--GAKALDVGSGSGILTACFARMvgcTGKVIGID 110
Cdd:PRK14968  13 FLLAENAVDkkGDRVLEVGTGSGIVAIVAAKN---GKKVVGVD 52
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 64-181 2.20e-04

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 40.55  E-value: 2.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  64 MHAYA--LELLFdQLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKddptllsSG---RVQL 138
Cdd:COG4122    1 MPEQGrlLYLLA-RLLGAKRILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFAR-------AGladRIRL 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 317373537 139 VVGDGR--MGYAEEAPYDAIHVGAAAPVVP---QALIDQLKPGGrLIL 181
Cdd:COG4122   73 ILGDALevLPRLADGPFDLVFIDADKSNYPdylELALPLLRPGG-LIV 119
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 73-181 2.58e-04

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 40.27  E-value: 2.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537   73 FDQLHEGaKALDVGSGSGILTACFARMVGctgkvigiDHIKELVDDSVNNVRKDDPTLLSSG--RVQLVVGDGRMGyAEE 150
Cdd:pfam05175  27 LPKDLSG-KVLDLGCGAGVLGAALAKESP--------DAELTMVDINARALESARENLAANGleNGEVVASDVYSG-VED 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 317373537  151 APYDAI------HVG-AAAPVVPQALI----DQLKPGGRLIL 181
Cdd:pfam05175  97 GKFDLIisnppfHAGlATTYNVAQRFIadakRHLRPGGELWI 138
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
63-181 3.20e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 39.98  E-value: 3.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  63 HMHAYALELLFDQlhEGAKALDVGSGSGILTACFARMVgctGKVIGIDhikeLVDDSVNNVRKddptllSSGRVQLVVGD 142
Cdd:COG4976   33 LLAEELLARLPPG--PFGRVLDLGCGTGLLGEALRPRG---YRLTGVD----LSEEMLAKARE------KGVYDRLLVAD 97

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 317373537 143 GRMGYAEEAPYDAI-------HVGAAAPVVpQALIDQLKPGGRLIL 181
Cdd:COG4976   98 LADLAEPDGRFDLIvaadvltYLGDLAAVF-AGVARALKPGGLFIF 142
PLN02366 PLN02366
spermidine synthase
 123-177 3.49e-04

spermidine synthase


Pssm-ID: 215208 [Multi-domain]  Cd Length: 308  Bit Score: 40.78  E-value: 3.49e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 317373537 123 VRKDDPtllssgRVQLVVGDGR--MGYAEEAPYDAIHVGAAAPVVP-QALIDQ---------LKPGG 177
Cdd:PLN02366 140 VGFDDP------RVNLHIGDGVefLKNAPEGTYDAIIVDSSDPVGPaQELFEKpffesvaraLRPGG 200
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
78-180 4.11e-04

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 40.12  E-value: 4.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537   78 EGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKDdptllSSGRVQLVVGDGRMGYAEEAPYDAIH 157
Cdd:pfam01209  42 RGNKFLDVAGGTGDWTFGLSDSAGSSGKVVGLDINENMLKEGEKKAKEE-----GKYNIEFLQGNAEELPFEDDSFDIVT 116

                          90       100
                  ....*....|....*....|....*....
gi 317373537  158 VGAA---APVVPQALIDQ---LKPGGRLI 180
Cdd:pfam01209 117 ISFGlrnFPDYLKVLKEAfrvLKPGGRVV 145
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 70-181 4.40e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 39.79  E-value: 4.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  70 ELLFDQL--HEGAKALDVGSGSGILTACFARMVGcTGKVIGIDhikelvddsVN---------NVRKDDPTllssgRVQL 138
Cdd:COG2813   39 RLLLEHLpePLGGRVLDLGCGYGVIGLALAKRNP-EARVTLVD---------VNaravelaraNAAANGLE-----NVEV 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 317373537 139 VVGDGRMGYAEEaPYDAI------HVGAAAPV-VPQALIDQ----LKPGGRLIL 181
Cdd:COG2813  104 LWSDGLSGVPDG-SFDLIlsnppfHAGRAVDKeVAHALIADaarhLRPGGELWL 156
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 66-181 5.46e-03

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 37.45  E-value: 5.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  66 AYALELLfdQLHEGAKALDVGSGSGILTACFARMvGCTGKVIGIDHIKELVDDSVNNVRKddptlLSSGRVQLVVGDGRM 145
Cdd:COG2242  237 ALTLAKL--ALRPGDVLWDIGAGSGSVSIEAARL-APGGRVYAIERDPERAALIRANARR-----FGVPNVEVVEGEAPE 308

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 317373537 146 GYAEEAPYDAIHVG----AAAPVVpQALIDQLKPGGRLIL 181
Cdd:COG2242  309 ALADLPDPDAVFIGgsggNLPEIL-EACWARLRPGGRLVA 347
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
66-181 6.25e-03

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 36.52  E-value: 6.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537  66 AYALELLfdQLHEGAKALDVGSGSG---ILTAC-FARMvgctgKVIGIDHIKELVDDSVNNVRKddptlLSSGRVQLVVG 141
Cdd:PRK08287  21 ALALSKL--ELHRAKHLIDVGAGTGsvsIEAALqFPSL-----QVTAIERNPDALRLIKENRQR-----FGCGNIDIIPG 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 317373537 142 DGRMGYAEEApyDAIHVGAAAPVVpQALID----QLKPGGRLIL 181
Cdd:PRK08287  89 EAPIELPGKA--DAIFIGGSGGNL-TAIIDwslaHLHPGGRLVL 129
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 68-181 7.08e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 35.87  E-value: 7.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 317373537   68 ALELLFDQLHEGAKALDVGSGSGILTACFARmVGCTGkvigidhikELVDDSVNNVRKDDPTllssgrVQLVVGDGRMGY 147
Cdd:pfam13489  12 LLLRLLPKLPSPGRVLDFGCGTGIFLRLLRA-QGFSV---------TGVDPSPIAIERALLN------VRFDQFDEQEAA 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 317373537  148 AEEAPYDAI-------HVgAAAPVVPQALIDQLKPGGRLIL 181
Cdd:pfam13489  76 VPAGKFDVIvarevleHV-PDPPALLRQIAALLKPGGLLLL 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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