|
Name |
Accession |
Description |
Interval |
E-value |
| Pyridoxal_deC |
pfam00282 |
Pyridoxal-dependent decarboxylase conserved domain; |
64-434 |
0e+00 |
|
Pyridoxal-dependent decarboxylase conserved domain;
Pssm-ID: 395219 Cd Length: 373 Bit Score: 527.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 64 PEDMKRLLDLDVPDRALPLQQLIEDCATTLKYQVKTGH-PHFFNQLSNGLDLISMAGEWLTATANTNMFTYEIAPVFILM 142
Cdd:pfam00282 1 PGYLKPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHsPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 143 ENVVLTKMREIIGWS------GGDSILAPGGSISNLYAFLAARHKMFPNYKEHG----SVGLPGTLVMFTSDQCHYSIKS 212
Cdd:pfam00282 81 ENVVMNWLGEMLGLPaeflgqEGGGVLQPGSSESNLLALLAARTKWIKRMKAAGkpadSSGILAKLVAYTSDQAHSSIEK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 213 CAAVCGLGtdhCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNATAGTTVLGAFDDINTIADICQKYNCWMHIDAAW 292
Cdd:pfam00282 161 AALYGGVK---LREIPSDDNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVDAAY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 293 GGGLLMSRKHRHpRFTGVERADSVTWNPHKLMGALLQCSTIHFKEDGLLISCNQMSAEYLFMTDKqydiSYDTGDKVIQC 372
Cdd:pfam00282 238 GGSAFICPEFRH-WLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEALQQAFQFNPLYLGHTDS----AYDTGHKQIPL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 68067453 373 GRHNDIFKLWLQWRAKGTEGFEQQQDRLMELVQYQLKRIREQSdRFHLILEPECVNVSFWYV 434
Cdd:pfam00282 313 SRRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDG-RFEICAEVGLGLVCFRLK 373
|
|
| GadA |
COG0076 |
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ... |
32-509 |
1.08e-115 |
|
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis
Pssm-ID: 439846 [Multi-domain] Cd Length: 460 Bit Score: 349.13 E-value: 1.08e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 32 ETREFLLKVIDVLLDFVKATNDRnekvLDFHHPEDMKRLLDLDVPDRALPLQQLIEDCATT-LKYQVKTGHPHFFNQLSN 110
Cdd:COG0076 1 EFRALLHQALDLAADYLAGLDRP----VFGPSPEELRAALDEPLPEEGLPPEEALAELEDLvLPGSVDWNHPRFLAFVTG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 111 GLDLISMAGEWLTATANTNMFTYEIAPVFILMENVVLTKMREIIGWS-GGDSILAPGGSISNLYAFLAARHKMFPNY-KE 188
Cdd:COG0076 77 GTTPAALAADLLASALNQNMGDWDTSPAATELEREVVRWLADLLGLPeGAGGVFTSGGTEANLLALLAARDRALARRvRA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 189 HGSVGLPGtLVMFTSDQCHYSIKSCAAVCGLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNATAGTTVLGA 268
Cdd:COG0076 157 EGLPGAPR-PRIVVSEEAHSSVDKAARLLGLGRDALRKVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 269 FDDINTIADICQKYNCWMHIDAAWGGGLLMSRKHRHpRFTGVERADSVTWNPHKLMGALLQCSTIHFKEDGLLISCNQMS 348
Cdd:COG0076 236 IDPLAEIADIAREHGLWLHVDAAYGGFALPSPELRH-LLDGIERADSITVDPHKWLYVPYGCGAVLVRDPELLREAFSFH 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 349 AEYLFMTDkqyDISYDTGDKVIQCGRHNDIFKLWLQWRAKGTEGFEQQQDRLMELVQYQLKRIREqSDRFHLILEPECVN 428
Cdd:COG0076 315 ASYLGPAD---DGVPNLGDYTLELSRRFRALKLWATLRALGREGYRELIERCIDLARYLAEGIAA-LPGFELLAPPELNI 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 429 VSFWYVPKRLRGVPHDAKKevelgkicpiIKGRMMQKGTLMVGYQPDDRRPNfFRSIISSAAVNEADVDFMLDEIHRLGD 508
Cdd:COG0076 391 VCFRYKPAGLDEEDALNYA----------LRDRLRARGRAFLSPTKLDGRVV-LRLVVLNPRTTEDDVDALLDDLREAAA 459
|
.
gi 68067453 509 D 509
Cdd:COG0076 460 E 460
|
|
| DOPA_deC_like |
cd06450 |
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
104-506 |
2.32e-115 |
|
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Pssm-ID: 99743 [Multi-domain] Cd Length: 345 Bit Score: 344.19 E-value: 2.32e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 104 FFNQLSNGLDLISMAGEWLTATANTNMFTYEIAPVFILMENVVLTKMREIIGW--SGGDSILAPGGSISNLYAFLAARHK 181
Cdd:cd06450 1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLpsEDADGVFTSGGSESNLLALLAARDR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 182 MFPNYKEHGSVGLPgTLVMFTSDQCHYSI-KSCAavcgLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNAT 260
Cdd:cd06450 81 ARKRLKAGGGRGID-KLVIVCSDQAHVSVeKAAA----YLDVKVRLVPVDEDGRMDPEALEAAIDEDKAEGLNPIMVVAT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 261 AGTTVLGAFDDINTIADICQKYNCWMHIDAAWGGGLLMSRKHRHpRFTGVERADSVTWNPHKLMGALLQCSTIHFKedgl 340
Cdd:cd06450 156 AGTTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRH-LDFGIERVDSISVDPHKYGLVPLGCSAVLVR---- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 341 liscnqmsaeylfmtdkqydisydtgdkviqcgrhndIFKLWLQWRAKGTEGFEQQQDRLMELVQYQLKRIREQsDRFHL 420
Cdd:cd06450 231 -------------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRAD-PGFEL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 421 ILEPECVNVSFWYVPkrlrgvphdakkEVELGKICPIIKGRMMQKGTLMVGYQPDDrRPNFFRSIISSAAVNEADVDFML 500
Cdd:cd06450 273 LGEPNLSLVCFRLKP------------SVKLDELNYDLSDRLNERGGWHVPATTLG-GPNVLRFVVTNPLTTRDDADALL 339
|
....*.
gi 68067453 501 DEIHRL 506
Cdd:cd06450 340 EDIERA 345
|
|
| PLN02590 |
PLN02590 |
probable tyrosine decarboxylase |
40-391 |
1.41e-31 |
|
probable tyrosine decarboxylase
Pssm-ID: 178200 [Multi-domain] Cd Length: 539 Bit Score: 127.90 E-value: 1.41e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 40 VIDVLLDFVKATNDRNEK--VLDFHHPEDMKRLLDLDVPDRALPLQQLIEDCATTLKYQVKTGH-PHFFNQLSNGLDLIS 116
Cdd:PLN02590 66 MVDFIADYYKNLQDSPQDfpVLSQVQPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQsPSYFAYYASSTSVAG 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 117 MAGEWLTATANTNMFTYEIAPVFILMENVVLTKMREII-------GWSGGDSILAPGGSISNLYAFLAARHKMFpnyKEH 189
Cdd:PLN02590 146 FLGEMLNAGLSVVGFTWLTSPAATELEIIVLDWLAKLLqlpdhflSTGNGGGVIQGTGCEAVLVVVLAARDRIL---KKV 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 190 GSVGLPgTLVMFTSDQCHYSIKSCAAVCGLGTDHCIVVPSDEHGK--MITSELERLILERKAKGDIPFFVNATAGTTVLG 267
Cdd:PLN02590 223 GKTLLP-QLVVYGSDQTHSSFRKACLIGGIHEENIRLLKTDSSTNygMPPESLEEAISHDLAKGFIPFFICATVGTTSSA 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 268 AFDDINTIADICQKYNCWMHIDAAWGGGLLMSRKHRhpRFT-GVERADSVTWNPHKLMGALLQCSTIHFKEDGLLISCNQ 346
Cdd:PLN02590 302 AVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYR--KFIdGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALK 379
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 68067453 347 MSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQWRAKGTE 391
Cdd:PLN02590 380 TNPEYLEFKVSKKDTVVNYKDWQISLSRRFRSLKLWMVLRLYGSE 424
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Pyridoxal_deC |
pfam00282 |
Pyridoxal-dependent decarboxylase conserved domain; |
64-434 |
0e+00 |
|
Pyridoxal-dependent decarboxylase conserved domain;
Pssm-ID: 395219 Cd Length: 373 Bit Score: 527.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 64 PEDMKRLLDLDVPDRALPLQQLIEDCATTLKYQVKTGH-PHFFNQLSNGLDLISMAGEWLTATANTNMFTYEIAPVFILM 142
Cdd:pfam00282 1 PGYLKPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHsPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 143 ENVVLTKMREIIGWS------GGDSILAPGGSISNLYAFLAARHKMFPNYKEHG----SVGLPGTLVMFTSDQCHYSIKS 212
Cdd:pfam00282 81 ENVVMNWLGEMLGLPaeflgqEGGGVLQPGSSESNLLALLAARTKWIKRMKAAGkpadSSGILAKLVAYTSDQAHSSIEK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 213 CAAVCGLGtdhCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNATAGTTVLGAFDDINTIADICQKYNCWMHIDAAW 292
Cdd:pfam00282 161 AALYGGVK---LREIPSDDNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVDAAY 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 293 GGGLLMSRKHRHpRFTGVERADSVTWNPHKLMGALLQCSTIHFKEDGLLISCNQMSAEYLFMTDKqydiSYDTGDKVIQC 372
Cdd:pfam00282 238 GGSAFICPEFRH-WLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEALQQAFQFNPLYLGHTDS----AYDTGHKQIPL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 68067453 373 GRHNDIFKLWLQWRAKGTEGFEQQQDRLMELVQYQLKRIREQSdRFHLILEPECVNVSFWYV 434
Cdd:pfam00282 313 SRRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDG-RFEICAEVGLGLVCFRLK 373
|
|
| GadA |
COG0076 |
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ... |
32-509 |
1.08e-115 |
|
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis
Pssm-ID: 439846 [Multi-domain] Cd Length: 460 Bit Score: 349.13 E-value: 1.08e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 32 ETREFLLKVIDVLLDFVKATNDRnekvLDFHHPEDMKRLLDLDVPDRALPLQQLIEDCATT-LKYQVKTGHPHFFNQLSN 110
Cdd:COG0076 1 EFRALLHQALDLAADYLAGLDRP----VFGPSPEELRAALDEPLPEEGLPPEEALAELEDLvLPGSVDWNHPRFLAFVTG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 111 GLDLISMAGEWLTATANTNMFTYEIAPVFILMENVVLTKMREIIGWS-GGDSILAPGGSISNLYAFLAARHKMFPNY-KE 188
Cdd:COG0076 77 GTTPAALAADLLASALNQNMGDWDTSPAATELEREVVRWLADLLGLPeGAGGVFTSGGTEANLLALLAARDRALARRvRA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 189 HGSVGLPGtLVMFTSDQCHYSIKSCAAVCGLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNATAGTTVLGA 268
Cdd:COG0076 157 EGLPGAPR-PRIVVSEEAHSSVDKAARLLGLGRDALRKVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 269 FDDINTIADICQKYNCWMHIDAAWGGGLLMSRKHRHpRFTGVERADSVTWNPHKLMGALLQCSTIHFKEDGLLISCNQMS 348
Cdd:COG0076 236 IDPLAEIADIAREHGLWLHVDAAYGGFALPSPELRH-LLDGIERADSITVDPHKWLYVPYGCGAVLVRDPELLREAFSFH 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 349 AEYLFMTDkqyDISYDTGDKVIQCGRHNDIFKLWLQWRAKGTEGFEQQQDRLMELVQYQLKRIREqSDRFHLILEPECVN 428
Cdd:COG0076 315 ASYLGPAD---DGVPNLGDYTLELSRRFRALKLWATLRALGREGYRELIERCIDLARYLAEGIAA-LPGFELLAPPELNI 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 429 VSFWYVPKRLRGVPHDAKKevelgkicpiIKGRMMQKGTLMVGYQPDDRRPNfFRSIISSAAVNEADVDFMLDEIHRLGD 508
Cdd:COG0076 391 VCFRYKPAGLDEEDALNYA----------LRDRLRARGRAFLSPTKLDGRVV-LRLVVLNPRTTEDDVDALLDDLREAAA 459
|
.
gi 68067453 509 D 509
Cdd:COG0076 460 E 460
|
|
| DOPA_deC_like |
cd06450 |
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
104-506 |
2.32e-115 |
|
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Pssm-ID: 99743 [Multi-domain] Cd Length: 345 Bit Score: 344.19 E-value: 2.32e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 104 FFNQLSNGLDLISMAGEWLTATANTNMFTYEIAPVFILMENVVLTKMREIIGW--SGGDSILAPGGSISNLYAFLAARHK 181
Cdd:cd06450 1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLpsEDADGVFTSGGSESNLLALLAARDR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 182 MFPNYKEHGSVGLPgTLVMFTSDQCHYSI-KSCAavcgLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNAT 260
Cdd:cd06450 81 ARKRLKAGGGRGID-KLVIVCSDQAHVSVeKAAA----YLDVKVRLVPVDEDGRMDPEALEAAIDEDKAEGLNPIMVVAT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 261 AGTTVLGAFDDINTIADICQKYNCWMHIDAAWGGGLLMSRKHRHpRFTGVERADSVTWNPHKLMGALLQCSTIHFKedgl 340
Cdd:cd06450 156 AGTTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRH-LDFGIERVDSISVDPHKYGLVPLGCSAVLVR---- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 341 liscnqmsaeylfmtdkqydisydtgdkviqcgrhndIFKLWLQWRAKGTEGFEQQQDRLMELVQYQLKRIREQsDRFHL 420
Cdd:cd06450 231 -------------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRAD-PGFEL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 421 ILEPECVNVSFWYVPkrlrgvphdakkEVELGKICPIIKGRMMQKGTLMVGYQPDDrRPNFFRSIISSAAVNEADVDFML 500
Cdd:cd06450 273 LGEPNLSLVCFRLKP------------SVKLDELNYDLSDRLNERGGWHVPATTLG-GPNVLRFVVTNPLTTRDDADALL 339
|
....*.
gi 68067453 501 DEIHRL 506
Cdd:cd06450 340 EDIERA 345
|
|
| PLN02590 |
PLN02590 |
probable tyrosine decarboxylase |
40-391 |
1.41e-31 |
|
probable tyrosine decarboxylase
Pssm-ID: 178200 [Multi-domain] Cd Length: 539 Bit Score: 127.90 E-value: 1.41e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 40 VIDVLLDFVKATNDRNEK--VLDFHHPEDMKRLLDLDVPDRALPLQQLIEDCATTLKYQVKTGH-PHFFNQLSNGLDLIS 116
Cdd:PLN02590 66 MVDFIADYYKNLQDSPQDfpVLSQVQPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQsPSYFAYYASSTSVAG 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 117 MAGEWLTATANTNMFTYEIAPVFILMENVVLTKMREII-------GWSGGDSILAPGGSISNLYAFLAARHKMFpnyKEH 189
Cdd:PLN02590 146 FLGEMLNAGLSVVGFTWLTSPAATELEIIVLDWLAKLLqlpdhflSTGNGGGVIQGTGCEAVLVVVLAARDRIL---KKV 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 190 GSVGLPgTLVMFTSDQCHYSIKSCAAVCGLGTDHCIVVPSDEHGK--MITSELERLILERKAKGDIPFFVNATAGTTVLG 267
Cdd:PLN02590 223 GKTLLP-QLVVYGSDQTHSSFRKACLIGGIHEENIRLLKTDSSTNygMPPESLEEAISHDLAKGFIPFFICATVGTTSSA 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 268 AFDDINTIADICQKYNCWMHIDAAWGGGLLMSRKHRhpRFT-GVERADSVTWNPHKLMGALLQCSTIHFKEDGLLISCNQ 346
Cdd:PLN02590 302 AVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYR--KFIdGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALK 379
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 68067453 347 MSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQWRAKGTE 391
Cdd:PLN02590 380 TNPEYLEFKVSKKDTVVNYKDWQISLSRRFRSLKLWMVLRLYGSE 424
|
|
| PLN02880 |
PLN02880 |
tyrosine decarboxylase |
34-435 |
4.57e-31 |
|
tyrosine decarboxylase
Pssm-ID: 215475 [Multi-domain] Cd Length: 490 Bit Score: 125.79 E-value: 4.57e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 34 REFLLKVIDVLLDFVKATndRNEKVLDFHHPEDMKRLLDLDVPDRALPLQQLIEDC-ATTLKYQVKTGHPHFFNQLSNGL 112
Cdd:PLN02880 16 RECGHRMVDFIADYYKSI--ENFPVLSQVQPGYLRELLPDSAPNQPETLDQVLDDVqAKILPGVTHWQSPNYFAYYPSNS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 113 DLISMAGEWLTATANTNMFTYEIAPVFILMENVVL---TKM----REIIGWSGGDSILAPGGSISNLYAFLAARHKMFpn 185
Cdd:PLN02880 94 SVAGFLGEMLSAGLNIVGFSWITSPAATELEMIVLdwlAKLlnlpEQFLSTGNGGGVIQGTASEAVLVVLLAARDRVL-- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 186 yKEHGSVGLPgTLVMFTSDQCHYSIKSCAAVCGLGTDHCIVVPSDEHGKMITSE--LERLILERKAKGDIPFFVNATAGT 263
Cdd:PLN02880 172 -RKVGKNALE-KLVVYASDQTHSALQKACQIAGIHPENCRLLKTDSSTNYALAPelLSEAISTDLSSGLIPFFLCATVGT 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 264 TVLGAFDDINTIADICQKYNCWMHIDAAWGGGLLMSRKHRHpRFTGVERADSVTWNPHKLMGALLQCSTIHFKEDGLLIS 343
Cdd:PLN02880 250 TSSTAVDPLLELGKIAKSNGMWFHVDAAYAGSACICPEYRH-YIDGVEEADSFNMNAHKWFLTNFDCSLLWVKDRNALIQ 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 344 CNQMSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQWRAKGTEGFEQQQDRLMELVQYqLKRIREQSDRFHLILE 423
Cdd:PLN02880 329 SLSTNPEFLKNKASQANSVVDYKDWQIPLGRRFRSLKLWMVLRLYGVENLQSYIRNHIKLAKE-FEQLVAQDSRFEVVTP 407
|
410
....*....|..
gi 68067453 424 PECVNVSFWYVP 435
Cdd:PLN02880 408 RIFSLVCFRLVP 419
|
|
| PRK02769 |
PRK02769 |
histidine decarboxylase; Provisional |
166-414 |
4.89e-19 |
|
histidine decarboxylase; Provisional
Pssm-ID: 235068 [Multi-domain] Cd Length: 380 Bit Score: 88.95 E-value: 4.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 166 GGSISNLYAFLAARhKMFPNykehgsvglpGTLVMftSDQCHYSIKSCAAVcgLGTDHCiVVPSDEHGKMITSELERLIL 245
Cdd:PRK02769 92 GGTEGNLYGCYLAR-ELFPD----------GTLYY--SKDTHYSVSKIARL--LRIKSR-VITSLPNGEIDYDDLISKIK 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 246 ERKAKgdiPFFVNATAGTTVLGAFDDINTIADICQKY---NCWMHIDAAWGGGLLMSRKHRHPrFTGVERADSVTWNPHK 322
Cdd:PRK02769 156 ENKNQ---PPIIFANIGTTMTGAIDNIKEIQEILKKIgidDYYIHADAALSGMILPFVNNPPP-FSFADGIDSIAISGHK 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 323 LMGALLQCStihfkedglliscnqmsaeyLFMTDKQY------DISY-DTGDKVIQCGR--HNDIFkLWLQWRAKGTEGF 393
Cdd:PRK02769 232 FIGSPMPCG--------------------IVLAKKKYverisvDVDYiGSRDQTISGSRngHTALL-LWAAIRSLGSKGL 290
|
250 260
....*....|....*....|.
gi 68067453 394 EQQQDRLMELVQYQLKRIREQ 414
Cdd:PRK02769 291 RQRVQHCLDMAQYAVDRLQAN 311
|
|
| PLN03032 |
PLN03032 |
serine decarboxylase; Provisional |
167-413 |
3.71e-12 |
|
serine decarboxylase; Provisional
Pssm-ID: 166673 [Multi-domain] Cd Length: 374 Bit Score: 67.93 E-value: 3.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 167 GSISNLYAFLAARHKmFPNYkehgsvglpgtlVMFTSDQCHYSIKSCAAVCGLgtdHCIVVPSDEHGKMITSELERLILE 246
Cdd:PLN03032 94 GTEGNLHGILVGREV-FPDG------------ILYASRESHYSVFKAARMYRM---EAVKVPTLPSGEIDYDDLERALAK 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 247 RKAKgdiPFFVNATAGTTVLGAFDDINTIADICQKYNC-----WMHIDAAWgGGLLMSRKHRHPRFTGVERADSVTWNPH 321
Cdd:PLN03032 158 NRDK---PAILNVNIGTTVKGAVDDLDRILRILKELGYtedrfYIHCDGAL-FGLMMPFVSRAPEVTFRKPIGSVSVSGH 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 322 KLMGALLQCST-IHFKEDGLLISCNqmsAEYLfmtdkqydisyDTGDKVIQCGR--HNDIFkLWLQWRAKGTEGFEQQQD 398
Cdd:PLN03032 234 KFLGCPMPCGVaLTRKKHVKALSQN---VEYL-----------NSRDATIMGSRngHAPLY-LWYTLRRKGYRGIKRDVQ 298
|
250
....*....|....*
gi 68067453 399 RLMELVQYQLKRIRE 413
Cdd:PLN03032 299 HCMRNAHYLKDRLTE 313
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
191-336 |
6.71e-12 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 63.94 E-value: 6.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 191 SVGLPGTLVMFtSDQCHYS-IKSCAAVCGLGTdhcIVVPSDEHGKMitsELERLILERKAKGDIPFFVNATAGTTVLGAF 269
Cdd:cd01494 36 ALLGPGDEVIV-DANGHGSrYWVAAELAGAKP---VPVPVDDAGYG---GLDVAILEELKAKPNVALIVITPNTTSGGVL 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 68067453 270 DDINTIADICQKYNCWMHIDAAWGGGlLMSRKHRHPRFtgvERADSVTWNPHKLMGAlLQCSTIHFK 336
Cdd:cd01494 109 VPLKEIRKIAKEYGILLLVDAASAGG-ASPAPGVLIPE---GGADVVTFSLHKNLGG-EGGGVVIVK 170
|
|
| PLN02263 |
PLN02263 |
serine decarboxylase |
167-413 |
2.44e-11 |
|
serine decarboxylase
Pssm-ID: 177904 [Multi-domain] Cd Length: 470 Bit Score: 65.61 E-value: 2.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 167 GSISNLYAFLAARhKMFPNYkehgsvglpgtlVMFTSDQCHYSIKSCAAVCGLGtdhCIVVPSDEHGKMITSELERLILE 246
Cdd:PLN02263 161 GTEGNLHGILVGR-EVFPDG------------ILYASRESHYSVFKAARMYRME---CVKVDTLVSGEIDCADFKAKLLA 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 247 RKAKgdiPFFVNATAGTTVLGAFDDINTIADICQKynC-------WMHIDAAWgGGLLMSRKHRHPRFTGVERADSVTWN 319
Cdd:PLN02263 225 NKDK---PAIINVNIGTTVKGAVDDLDLVIKTLEE--CgfsqdrfYIHCDGAL-FGLMMPFVKRAPKVTFKKPIGSVSVS 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 320 PHKLMGALLQCST-IHFKEDGLLISCNqmsAEYLfmtdkqydisyDTGDKVIQCGR--HNDIFkLWLQWRAKGTEGFEQQ 396
Cdd:PLN02263 299 GHKFVGCPMPCGVqITRMEHINVLSSN---VEYL-----------ASRDATIMGSRngHAPIF-LWYTLNRKGYRGFQKE 363
|
250
....*....|....*..
gi 68067453 397 QDRLMELVQYQLKRIRE 413
Cdd:PLN02263 364 VQKCLRNAHYLKDRLRE 380
|
|
| Orn_deC_like |
cd00615 |
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
267-355 |
1.57e-06 |
|
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine decarboxylase (LDC). ODC is a dodecamer composed of six homodimers and catalyzes the decarboxylation of tryptophan. ADC catalyzes the decarboxylation of arginine and LDC catalyzes the decarboxylation of lysine. Members of this family are widely found in all three forms of life.
Pssm-ID: 99739 [Multi-domain] Cd Length: 294 Bit Score: 49.94 E-value: 1.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 267 GAFDDINTIADICQKYNCWMHIDAAWGGGLlmsrkHRHPRF---TGVERADSVTWNPHKLMGALLQCSTIHFKEDglLIS 343
Cdd:cd00615 167 GICYNLRKIVEEAHHRGLPVLVDEAHGAHF-----RFHPILpssAAMAGADIVVQSTHKTLPALTQGSMIHVKGD--LVN 239
|
90
....*....|..
gi 68067453 344 CNQMSaEYLFMT 355
Cdd:cd00615 240 PDRVN-EALNLH 250
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
226-291 |
1.38e-04 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 44.16 E-value: 1.38e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 68067453 226 VVPSDEHGKMITSELERLILERKAkgdipfFVNATAGTTVLGAFDDINTIADICQKYNCWMHIDAA 291
Cdd:pfam00266 118 VLPLDEDGLLDLDELEKLITPKTK------LVAITHVSNVTGTIQPVPEIGKLAHQYGALVLVDAA 177
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
226-325 |
1.22e-03 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 41.28 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68067453 226 VVPSDEHGKMITSELERLIlERKAKgdipfFVNATAGTTVLGAFDDINTIADICQKYNCWMHIDAAWGGGllmsrkHRHP 305
Cdd:COG0520 133 VIPLDEDGELDLEALEALL-TPRTK-----LVAVTHVSNVTGTVNPVKEIAALAHAHGALVLVDGAQSVP------HLPV 200
|
90 100
....*....|....*....|
gi 68067453 306 RFTGVErADSVTWNPHKLMG 325
Cdd:COG0520 201 DVQALG-CDFYAFSGHKLYG 219
|
|
| |
